PAN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.22531529
2* RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.10073271
3regulation of mesoderm development (GO:2000380)4.07908375
4DNA double-strand break processing (GO:0000729)4.05972849
5definitive hemopoiesis (GO:0060216)3.97178956
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.91367732
7L-fucose catabolic process (GO:0042355)3.73611344
8fucose catabolic process (GO:0019317)3.73611344
9L-fucose metabolic process (GO:0042354)3.73611344
10rRNA catabolic process (GO:0016075)3.71070019
11meiotic chromosome segregation (GO:0045132)3.65490502
12water-soluble vitamin biosynthetic process (GO:0042364)3.62699032
13positive regulation of gamma-delta T cell activation (GO:0046645)3.43222760
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.38742307
15kidney morphogenesis (GO:0060993)3.36147162
16positive regulation of granulocyte differentiation (GO:0030854)3.36065831
17histone H3-K4 trimethylation (GO:0080182)3.25101753
18somite development (GO:0061053)3.25045835
19megakaryocyte development (GO:0035855)3.20170360
20adenosine metabolic process (GO:0046085)3.17221238
21piRNA metabolic process (GO:0034587)3.13901819
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.09434699
23indolalkylamine metabolic process (GO:0006586)3.08194634
24regulation of meiosis I (GO:0060631)3.08118203
25ribosomal small subunit assembly (GO:0000028)3.04750447
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.02298233
27regulation of B cell apoptotic process (GO:0002902)3.02057844
28double-strand break repair via homologous recombination (GO:0000724)3.01244389
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00481577
30recombinational repair (GO:0000725)2.98764588
31response to pheromone (GO:0019236)2.97995367
32protein polyglutamylation (GO:0018095)2.96214856
33negative regulation of phagocytosis (GO:0050765)2.95977162
34magnesium ion transport (GO:0015693)2.95273181
35phosphatidylethanolamine metabolic process (GO:0046337)2.93533637
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93310886
37synapsis (GO:0007129)2.93279391
38platelet dense granule organization (GO:0060155)2.91282091
39transepithelial transport (GO:0070633)2.90999993
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90424254
41neural tube formation (GO:0001841)2.90308007
42regulation of B cell receptor signaling pathway (GO:0050855)2.90262962
43prostate gland growth (GO:0060736)2.88885984
44mast cell activation (GO:0045576)2.87424213
45kinetochore organization (GO:0051383)2.85622554
46axoneme assembly (GO:0035082)2.85051256
47negative regulation of telomere maintenance (GO:0032205)2.84907151
48mitotic sister chromatid cohesion (GO:0007064)2.83931094
49phosphatidylethanolamine biosynthetic process (GO:0006646)2.83654434
50interferon-gamma production (GO:0032609)2.81019817
51somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80609077
52somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80609077
53isotype switching (GO:0045190)2.80609077
54regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.80456335
55lactate metabolic process (GO:0006089)2.79165675
56DNA methylation involved in gamete generation (GO:0043046)2.78281660
57positive regulation of B cell differentiation (GO:0045579)2.77814769
58negative regulation of thymocyte apoptotic process (GO:0070244)2.77623631
59preassembly of GPI anchor in ER membrane (GO:0016254)2.74976856
60lymphoid progenitor cell differentiation (GO:0002320)2.73726129
61organ formation (GO:0048645)2.73368293
62poly(A)+ mRNA export from nucleus (GO:0016973)2.72109787
63germinal center formation (GO:0002467)2.71606319
64parental behavior (GO:0060746)2.69982722
65tryptophan metabolic process (GO:0006568)2.68939224
66regulation of telomere maintenance (GO:0032204)2.68874521
67myeloid dendritic cell activation (GO:0001773)2.68799804
68epithelial cilium movement (GO:0003351)2.68298423
69regulation of B cell differentiation (GO:0045577)2.67204615
70negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.66458679
71tryptophan catabolic process (GO:0006569)2.66326682
72indole-containing compound catabolic process (GO:0042436)2.66326682
73indolalkylamine catabolic process (GO:0046218)2.66326682
74dendritic cell chemotaxis (GO:0002407)2.64850183
75maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.62690541
76histone H3-K4 methylation (GO:0051568)2.61323733
77aggressive behavior (GO:0002118)2.60266685
78negative regulation of alpha-beta T cell differentiation (GO:0046639)2.60127980
79microtubule depolymerization (GO:0007019)2.59825764
80positive regulation by symbiont of host defense response (GO:0052509)2.59554218
81modulation by symbiont of host defense response (GO:0052031)2.59554218
82modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.59554218
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.59554218
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.59554218
85modulation by symbiont of host immune response (GO:0052553)2.59554218
86regulation of RIG-I signaling pathway (GO:0039535)2.58672947
87B cell homeostasis (GO:0001782)2.58415670
88centriole replication (GO:0007099)2.57460739
89positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.57391659
90hepatocyte apoptotic process (GO:0097284)2.56962136
91centriole assembly (GO:0098534)2.56347281
92sister chromatid cohesion (GO:0007062)2.55972138
93regulation of granulocyte differentiation (GO:0030852)2.55853510
94behavioral response to nicotine (GO:0035095)2.55671651
95peptidyl-lysine trimethylation (GO:0018023)2.55299674
96histone H2A ubiquitination (GO:0033522)2.55238785
97embryonic hemopoiesis (GO:0035162)2.55206583
98protein sumoylation (GO:0016925)2.54954321
99ncRNA catabolic process (GO:0034661)2.54811735
100DNA synthesis involved in DNA repair (GO:0000731)2.54288702
101positive regulation of mRNA catabolic process (GO:0061014)2.54123540
102regulation of rhodopsin mediated signaling pathway (GO:0022400)2.53384516
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52968372
104endoderm formation (GO:0001706)2.52383161
105embryonic epithelial tube formation (GO:0001838)2.51091409
106dendritic cell migration (GO:0036336)2.50765293
107negative regulation of T-helper cell differentiation (GO:0045623)2.50743824
108negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.50743824
109positive regulation of defense response to virus by host (GO:0002230)2.50121237
110photoreceptor cell maintenance (GO:0045494)2.50074550
111growth hormone receptor signaling pathway (GO:0060396)2.49386433
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48501936
113defense response to protozoan (GO:0042832)2.48451870
114attachment of spindle microtubules to kinetochore (GO:0008608)2.47607532
115antigen processing and presentation of endogenous antigen (GO:0019883)2.46745118
116intra-S DNA damage checkpoint (GO:0031573)2.46294926
117keratinocyte development (GO:0003334)2.46219753
118monoubiquitinated protein deubiquitination (GO:0035520)2.44535794
119neutrophil activation (GO:0042119)2.44170770
120regulation of germinal center formation (GO:0002634)2.43725401
121response to protozoan (GO:0001562)2.43721830
122CENP-A containing nucleosome assembly (GO:0034080)2.43667214
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.43640199
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.43640199
125antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.43635395
126antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.43635395
127protein K11-linked deubiquitination (GO:0035871)2.42312074
128negative regulation of mast cell activation (GO:0033004)2.42311151
129replication fork processing (GO:0031297)2.41954200
130prenylation (GO:0097354)2.41932871
131protein prenylation (GO:0018342)2.41932871
132regulation of DNA endoreduplication (GO:0032875)2.41642372
133DNA catabolic process, exonucleolytic (GO:0000738)2.41579147
134histamine secretion (GO:0001821)2.41092477
135T cell homeostasis (GO:0043029)2.40986645
136respiratory chain complex IV assembly (GO:0008535)2.40849098
137regulation of histone H3-K27 methylation (GO:0061085)2.40717675
138rhodopsin mediated signaling pathway (GO:0016056)2.40440396
139GPI anchor metabolic process (GO:0006505)2.39801878
140kinetochore assembly (GO:0051382)2.39135059
141cytochrome complex assembly (GO:0017004)2.38990512
142B cell receptor signaling pathway (GO:0050853)2.38846137
143neutrophil activation involved in immune response (GO:0002283)2.37760180
144histone H3-K9 demethylation (GO:0033169)2.37594194
145immunoglobulin mediated immune response (GO:0016064)2.37519376
146negative regulation of granulocyte differentiation (GO:0030853)2.37219265
147myoblast migration (GO:0051451)2.37042436
148telomere maintenance via recombination (GO:0000722)2.36875859
149regulation of regulatory T cell differentiation (GO:0045589)2.36505697
150limb bud formation (GO:0060174)2.35742147
151positive regulation of antigen processing and presentation (GO:0002579)2.35657317
152sulfation (GO:0051923)2.34575400
153mannosylation (GO:0097502)2.33934710
154lymphocyte homeostasis (GO:0002260)2.33446899
155histone mRNA catabolic process (GO:0071044)2.32531671
156epithelial tube formation (GO:0072175)2.32300002
157programmed necrotic cell death (GO:0097300)2.32162787
158regulation of T cell receptor signaling pathway (GO:0050856)2.32159704
159purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.31699612
160detection of light stimulus involved in visual perception (GO:0050908)2.31308891
161detection of light stimulus involved in sensory perception (GO:0050962)2.31308891
162NIK/NF-kappaB signaling (GO:0038061)2.30970416
163protein K6-linked ubiquitination (GO:0085020)2.29691103
164histone exchange (GO:0043486)2.29592202
165cellular response to ATP (GO:0071318)2.29219201
166regulation of gamma-delta T cell activation (GO:0046643)2.29103105
167CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.29095956
168response to muramyl dipeptide (GO:0032495)2.28712647
169positive regulation of T cell differentiation in thymus (GO:0033089)2.28587282
170negative regulation of translation, ncRNA-mediated (GO:0040033)2.28442097
171regulation of translation, ncRNA-mediated (GO:0045974)2.28442097
172negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.28442097
173energy homeostasis (GO:0097009)2.28432353
174necroptotic process (GO:0070266)2.27625870
175necrotic cell death (GO:0070265)2.26299554
176chromatin remodeling at centromere (GO:0031055)2.25535891
177RNA-dependent DNA replication (GO:0006278)2.24542017
178regulation of histone H3-K9 methylation (GO:0051570)2.24346358
179positive regulation of interferon-alpha production (GO:0032727)2.23723462
180regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.23646208
181angiogenesis involved in wound healing (GO:0060055)2.23442175
182regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.23437563
183regulation of necroptotic process (GO:0060544)2.23422647
184CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.22617295
185T-helper cell differentiation (GO:0042093)2.22617295
186response to peptidoglycan (GO:0032494)2.22554362
187lymph node development (GO:0048535)2.22204395
188regulation of fibroblast apoptotic process (GO:2000269)2.22019519
189regulation of mast cell activation (GO:0033003)2.21774505
190B cell differentiation (GO:0030183)2.21722151
191histone H3-K36 demethylation (GO:0070544)2.21601586
192regulation of establishment of cell polarity (GO:2000114)2.20659636
193nuclear pore complex assembly (GO:0051292)2.20616052
194mast cell activation involved in immune response (GO:0002279)2.20539298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.63415819
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.56076378
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.29450985
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.45755021
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.45058472
6SCL_19346495_ChIP-Seq_HPC-7_Human3.27200102
7VDR_22108803_ChIP-Seq_LS180_Human3.18036807
8ZNF274_21170338_ChIP-Seq_K562_Hela3.11648131
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.95781715
10GBX2_23144817_ChIP-Seq_PC3_Human2.83408387
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.74750633
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71569702
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.68621445
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67651743
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63361915
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51077067
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49453217
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46136211
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.39777741
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.32375977
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26771257
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.23536323
23* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13119769
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10814067
25FUS_26573619_Chip-Seq_HEK293_Human2.10175014
26P300_19829295_ChIP-Seq_ESCs_Human2.08803471
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.08738933
28RUNX_20019798_ChIP-Seq_JUKART_Human2.07666631
29SMAD_19615063_ChIP-ChIP_OVARY_Human2.06850299
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01412254
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00232236
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97314740
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96773337
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.89078987
35MYB_26560356_Chip-Seq_TH2_Human1.88380544
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.88346444
37TAF15_26573619_Chip-Seq_HEK293_Human1.87160957
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85354763
39* SPI1_23547873_ChIP-Seq_NB4_Human1.84019789
40* MYB_26560356_Chip-Seq_TH1_Human1.81443110
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80073275
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79008897
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75254176
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75059691
45ER_23166858_ChIP-Seq_MCF-7_Human1.72860028
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67580423
47ELK1_19687146_ChIP-ChIP_HELA_Human1.67287752
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67150068
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.66064674
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65246791
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64329941
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.63446852
53GATA1_22025678_ChIP-Seq_K562_Human1.59040916
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.57893256
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57324298
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56163614
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54266995
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53180855
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.52416854
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50816077
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48334973
62BCAT_22108803_ChIP-Seq_LS180_Human1.48038565
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46715312
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45589208
65CBP_20019798_ChIP-Seq_JUKART_Human1.44416198
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44416198
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.44168309
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43187968
69* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43154214
70NANOG_19829295_ChIP-Seq_ESCs_Human1.42636946
71SOX2_19829295_ChIP-Seq_ESCs_Human1.42636946
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40921985
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40417712
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40208507
75AR_25329375_ChIP-Seq_VCAP_Human1.38729832
76MYC_18940864_ChIP-ChIP_HL60_Human1.38163012
77* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37376313
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35781090
79STAT3_23295773_ChIP-Seq_U87_Human1.35475054
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34990308
81* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33911076
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.33519163
83TCF4_23295773_ChIP-Seq_U87_Human1.32882903
84* RUNX1_22412390_ChIP-Seq_EML_Mouse1.32088640
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31470203
86SMAD4_21799915_ChIP-Seq_A2780_Human1.30905561
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.30320580
88PU_27001747_Chip-Seq_BMDM_Mouse1.30231066
89TP53_22573176_ChIP-Seq_HFKS_Human1.30067377
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.29095929
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28822622
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28497638
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28109794
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26621704
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.25641731
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25027975
97CIITA_25753668_ChIP-Seq_RAJI_Human1.24903804
98* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24252818
99POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22699560
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.22464874
101* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21465525
102TCF4_22108803_ChIP-Seq_LS180_Human1.20920935
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20356791
104CDX2_22108803_ChIP-Seq_LS180_Human1.20093772
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.18997150
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18986676
107* VDR_23849224_ChIP-Seq_CD4+_Human1.18913155
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18548234
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18548234
110IRF1_19129219_ChIP-ChIP_H3396_Human1.18064403
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18009166
112* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16991061
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.14581036
114* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14580217
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.14411597
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.14396862
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14396862
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13709727
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11949402
120* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10997291
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.10941012
122RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10861142
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10781577
124EWS_26573619_Chip-Seq_HEK293_Human1.10396991
125RUNX2_22187159_ChIP-Seq_PCA_Human1.10056308
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09211180
127FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08580828
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08386818
129FOXP3_21729870_ChIP-Seq_TREG_Human1.08386241
130VDR_24763502_ChIP-Seq_THP-1_Human1.08161043
131* GATA3_27048872_Chip-Seq_THYMUS_Human1.07997833
132AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06793357
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05155127
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05051648
135* RNF2_27304074_Chip-Seq_NSC_Mouse1.04687227
136PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03605428
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02264328
138EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01524442
139MAF_26560356_Chip-Seq_TH1_Human1.00141787
140GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99444614
141BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99426325
142GATA3_26560356_Chip-Seq_TH2_Human0.99023131
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.99014321
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.96772988
145CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96694959
146MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96679057
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95834297
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94912581
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94804493
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92819116
151PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92756948
152NMYC_18555785_Chip-Seq_ESCs_Mouse0.92388013
153E2F1_18555785_Chip-Seq_ESCs_Mouse0.90698017
154P53_22387025_ChIP-Seq_ESCs_Mouse0.90308604
155OCT4_18555785_Chip-Seq_ESCs_Mouse0.90247536
156SPI1_23127762_ChIP-Seq_K562_Human0.88784368
157EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88336488
158* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88050727
159IGF1R_20145208_ChIP-Seq_DFB_Human0.87573683
160UTX_26944678_Chip-Seq_JUKART_Human0.87167480
161VDR_24787735_ChIP-Seq_THP-1_Human0.87074450
162RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86383645
163CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83971289
164TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83374860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.79591241
2MP0002396_abnormal_hematopoietic_system3.47440264
3MP0001835_abnormal_antigen_presentation3.45435903
4MP0003195_calcinosis3.38771293
5MP0008057_abnormal_DNA_replication3.36693320
6MP0002102_abnormal_ear_morphology2.88143399
7MP0002009_preneoplasia2.64814618
8MP0003763_abnormal_thymus_physiology2.60921987
9MP0005174_abnormal_tail_pigmentation2.59861704
10MP0002166_altered_tumor_susceptibility2.56735025
11MP0000569_abnormal_digit_pigmentation2.49427315
12MP0005671_abnormal_response_to2.47480592
13MP0004808_abnormal_hematopoietic_stem2.43452987
14MP0001968_abnormal_touch/_nociception2.30337183
15MP0008007_abnormal_cellular_replicative2.28035310
16MP0002006_tumorigenesis2.26681176
17MP0000015_abnormal_ear_pigmentation2.22054588
18MP0001800_abnormal_humoral_immune2.12744359
19MP0010094_abnormal_chromosome_stability2.12071220
20MP0002837_dystrophic_cardiac_calcinosis2.03560610
21MP0002148_abnormal_hypersensitivity_rea2.00467399
22MP0005075_abnormal_melanosome_morpholog2.00260949
23MP0003283_abnormal_digestive_organ1.99039740
24MP0002452_abnormal_antigen_presenting1.98605697
25MP0002736_abnormal_nociception_after1.96499695
26MP0002876_abnormal_thyroid_physiology1.96466245
27MP0009785_altered_susceptibility_to1.96281260
28MP0008058_abnormal_DNA_repair1.95115155
29MP0002398_abnormal_bone_marrow1.95022284
30MP0001545_abnormal_hematopoietic_system1.94672540
31MP0005397_hematopoietic_system_phenotyp1.94672540
32MP0006072_abnormal_retinal_apoptosis1.94187755
33MP0002420_abnormal_adaptive_immunity1.92224906
34MP0006292_abnormal_olfactory_placode1.91874598
35MP0001819_abnormal_immune_cell1.90623890
36MP0005000_abnormal_immune_tolerance1.85758059
37MP0002723_abnormal_immune_serum1.84623733
38MP0001790_abnormal_immune_system1.82382793
39MP0005387_immune_system_phenotype1.82382793
40MP0002095_abnormal_skin_pigmentation1.80047339
41MP0005551_abnormal_eye_electrophysiolog1.79697537
42MP0002419_abnormal_innate_immunity1.77090183
43MP0004885_abnormal_endolymph1.75435455
44MP0003724_increased_susceptibility_to1.74553854
45MP0008872_abnormal_physiological_respon1.74168916
46MP0000685_abnormal_immune_system1.72077738
47MP0005025_abnormal_response_to1.66286477
48MP0000716_abnormal_immune_system1.65993309
49MP0005464_abnormal_platelet_physiology1.58738709
50MP0000689_abnormal_spleen_morphology1.57767168
51MP0002405_respiratory_system_inflammati1.57698582
52MP0003077_abnormal_cell_cycle1.57418123
53MP0010678_abnormal_skin_adnexa1.56960603
54MP0008877_abnormal_DNA_methylation1.56918511
55MP0003646_muscle_fatigue1.56398982
56MP0006054_spinal_hemorrhage1.55336398
57MP0003787_abnormal_imprinting1.54066441
58MP0005367_renal/urinary_system_phenotyp1.51861088
59MP0003436_decreased_susceptibility_to1.50705578
60MP0001188_hyperpigmentation1.49477432
61MP0000427_abnormal_hair_cycle1.48731397
62MP0002722_abnormal_immune_system1.47988324
63MP0000703_abnormal_thymus_morphology1.47401837
64MP0002877_abnormal_melanocyte_morpholog1.44264733
65MP0003111_abnormal_nucleus_morphology1.44144344
66MP0001485_abnormal_pinna_reflex1.43455373
67MP0005253_abnormal_eye_physiology1.42229350
68MP0005409_darkened_coat_color1.41947855
69MP0003693_abnormal_embryo_hatching1.41742760
70MP0002254_reproductive_system_inflammat1.39894454
71MP0010155_abnormal_intestine_physiology1.39439791
72MP0002429_abnormal_blood_cell1.38908738
73MP0004381_abnormal_hair_follicle1.36956878
74MP0000631_abnormal_neuroendocrine_gland1.36736322
75MP0000490_abnormal_crypts_of1.36541997
76MP0005220_abnormal_exocrine_pancreas1.36103900
77MP0003119_abnormal_digestive_system1.34276327
78MP0002160_abnormal_reproductive_system1.34050620
79MP0003943_abnormal_hepatobiliary_system1.31081473
80MP0001986_abnormal_taste_sensitivity1.28236777
81MP0002751_abnormal_autonomic_nervous1.27815978
82MP0002132_abnormal_respiratory_system1.26816050
83MP0000372_irregular_coat_pigmentation1.24523700
84MP0008995_early_reproductive_senescence1.24467859
85MP0002277_abnormal_respiratory_mucosa1.19622680
86MP0003718_maternal_effect1.18120654
87MP0009333_abnormal_splenocyte_physiolog1.17813757
88MP0003786_premature_aging1.17752459
89MP0002282_abnormal_trachea_morphology1.14947974
90MP0001853_heart_inflammation1.14375065
91MP0004782_abnormal_surfactant_physiolog1.12885350
92MP0005310_abnormal_salivary_gland1.12501916
93MP0010307_abnormal_tumor_latency1.09342645
94MP0000465_gastrointestinal_hemorrhage1.09000522
95MP0008775_abnormal_heart_ventricle1.08551366
96MP0009278_abnormal_bone_marrow1.08335138
97MP0009697_abnormal_copulation1.04775208
98MP0000613_abnormal_salivary_gland1.03724574
99MP0001486_abnormal_startle_reflex1.03046985
100MP0001873_stomach_inflammation1.02169397
101MP0003011_delayed_dark_adaptation1.00972282
102MP0003567_abnormal_fetal_cardiomyocyte0.97652344
103MP0001177_atelectasis0.97380888
104MP0001119_abnormal_female_reproductive0.96282511
105MP0002163_abnormal_gland_morphology0.95266957
106MP0005408_hypopigmentation0.94959081
107MP0001984_abnormal_olfaction0.94818153
108MP0000383_abnormal_hair_follicle0.94695297
109MP0003828_pulmonary_edema0.94340355
110MP0001845_abnormal_inflammatory_respons0.94300368
111MP0005410_abnormal_fertilization0.93776040
112MP0001879_abnormal_lymphatic_vessel0.93112673
113MP0003890_abnormal_embryonic-extraembry0.92079392
114MP0002019_abnormal_tumor_incidence0.91782957
115MP0000371_diluted_coat_color0.91251403
116MP0005645_abnormal_hypothalamus_physiol0.90700103
117MP0002928_abnormal_bile_duct0.90079558
118MP0005379_endocrine/exocrine_gland_phen0.87098676
119MP0005647_abnormal_sex_gland0.86985373
120MP0004215_abnormal_myocardial_fiber0.86053087
121MP0005084_abnormal_gallbladder_morpholo0.85355275
122MP0000858_altered_metastatic_potential0.85348320
123MP0001764_abnormal_homeostasis0.85168698
124MP0001186_pigmentation_phenotype0.85040801
125MP0000653_abnormal_sex_gland0.83803726
126MP0002075_abnormal_coat/hair_pigmentati0.83529309
127MP0000230_abnormal_systemic_arterial0.83486588
128MP0003252_abnormal_bile_duct0.82762260
129MP0003866_abnormal_defecation0.81682780
130MP0003121_genomic_imprinting0.78672687
131MP0001293_anophthalmia0.76424587
132MP0001501_abnormal_sleep_pattern0.76415868
133MP0000647_abnormal_sebaceous_gland0.76126293
134MP0003937_abnormal_limbs/digits/tail_de0.74621718
135MP0003448_altered_tumor_morphology0.73452130
136MP0000767_abnormal_smooth_muscle0.73285381
137MP0004947_skin_inflammation0.72443003
138MP0001145_abnormal_male_reproductive0.72148011
139MP0004133_heterotaxia0.71644507
140MP0001919_abnormal_reproductive_system0.71436618
141MP0004142_abnormal_muscle_tone0.71185940
142MP0004085_abnormal_heartbeat0.71185419
143MP0002210_abnormal_sex_determination0.70958868
144MP0009745_abnormal_behavioral_response0.70939469
145MP0004043_abnormal_pH_regulation0.70541039
146MP0001851_eye_inflammation0.70070264
147MP0005646_abnormal_pituitary_gland0.70004729
148MP0003938_abnormal_ear_development0.68048596
149MP0002938_white_spotting0.66906641
150MP0002272_abnormal_nervous_system0.66385944
151MP0000313_abnormal_cell_death0.66316922
152MP0002735_abnormal_chemical_nociception0.65820891
153MP0010386_abnormal_urinary_bladder0.65676366
154MP0003880_abnormal_central_pattern0.65321913
155MP0001929_abnormal_gametogenesis0.64833360
156MP0009764_decreased_sensitivity_to0.64749120
157MP0004147_increased_porphyrin_level0.64447037
158MP0004264_abnormal_extraembryonic_tissu0.64035893
159MP0003941_abnormal_skin_development0.63776804
160MP0005389_reproductive_system_phenotype0.62304382
161MP0000350_abnormal_cell_proliferation0.61551209
162MP0000516_abnormal_urinary_system0.58855329

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.44333782
2Chromsome breakage (HP:0040012)4.20606579
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.04060022
4Pancreatic cysts (HP:0001737)4.00290411
5Prostate neoplasm (HP:0100787)3.59506537
6Acute myeloid leukemia (HP:0004808)3.51620619
7Abolished electroretinogram (ERG) (HP:0000550)3.21117194
8Recurrent abscess formation (HP:0002722)3.20188750
9Abnormality of the prostate (HP:0008775)3.13862537
10Lip pit (HP:0100267)3.09802114
11Abnormality of the renal cortex (HP:0011035)3.08521559
12Molar tooth sign on MRI (HP:0002419)3.06528698
13Abnormality of midbrain morphology (HP:0002418)3.06528698
14Nephronophthisis (HP:0000090)3.05270984
15Congenital stationary night blindness (HP:0007642)3.01364385
16Clubbing of toes (HP:0100760)2.91469161
17Thyroiditis (HP:0100646)2.89829509
18Abnormality of the renal medulla (HP:0100957)2.83865930
19Recurrent bacterial skin infections (HP:0005406)2.82249913
20Acute lymphatic leukemia (HP:0006721)2.79958973
21Myelodysplasia (HP:0002863)2.76093809
22Asplenia (HP:0001746)2.75346156
23Congenital, generalized hypertrichosis (HP:0004540)2.74848911
24Recurrent viral infections (HP:0004429)2.74554794
25Aplasia/Hypoplasia of the spleen (HP:0010451)2.71295840
26Myositis (HP:0100614)2.69521364
27Abnormality of chromosome stability (HP:0003220)2.65335687
28Thrombocytosis (HP:0001894)2.65239994
29Abnormality of the columella (HP:0009929)2.61925782
30Bile duct proliferation (HP:0001408)2.61184544
31Abnormal biliary tract physiology (HP:0012439)2.61184544
32IgM deficiency (HP:0002850)2.59754055
33Recurrent fungal infections (HP:0002841)2.58446901
34Optic neuritis (HP:0100653)2.58377807
35Retrobulbar optic neuritis (HP:0100654)2.58377807
36Methylmalonic acidemia (HP:0002912)2.56273383
37Abnormality of the proximal phalanges of the hand (HP:0009834)2.55490544
38Syringomyelia (HP:0003396)2.54332874
39Spinal cord lesions (HP:0100561)2.54332874
40Mediastinal lymphadenopathy (HP:0100721)2.53871645
41Prolonged bleeding time (HP:0003010)2.53022718
42Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.52575441
43Absent frontal sinuses (HP:0002688)2.51417226
44Meningitis (HP:0001287)2.48508979
45Progressive inability to walk (HP:0002505)2.46645518
46Abnormal drinking behavior (HP:0030082)2.46576411
47Polydipsia (HP:0001959)2.46576411
48Aplastic anemia (HP:0001915)2.44681211
49Agammaglobulinemia (HP:0004432)2.44476980
50Volvulus (HP:0002580)2.41081116
51Panhypogammaglobulinemia (HP:0003139)2.39722446
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.39656792
53Granulocytopenia (HP:0001913)2.38490345
54Abnormality of B cell number (HP:0010975)2.38355091
55B lymphocytopenia (HP:0010976)2.38355091
56Renal cortical cysts (HP:0000803)2.36855923
57Ectopic kidney (HP:0000086)2.34616910
58Pendular nystagmus (HP:0012043)2.33957251
59Abnormality of the preputium (HP:0100587)2.30662332
60Autoimmune thrombocytopenia (HP:0001973)2.28144853
61Abnormality of the phalanges of the 5th finger (HP:0004213)2.28089284
62Cystic liver disease (HP:0006706)2.26459173
63Neoplasm of the adrenal cortex (HP:0100641)2.23561738
64Short hallux (HP:0010109)2.21703327
65Abnormality of the nasal septum (HP:0000419)2.21657160
66Eosinophilia (HP:0001880)2.21336549
67Papillary thyroid carcinoma (HP:0002895)2.21303966
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.21039272
69Absent/shortened dynein arms (HP:0200106)2.21039272
70Aplasia/Hypoplasia of the hallux (HP:0008362)2.19491414
71Short 1st metacarpal (HP:0010034)2.18453325
72Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.18453325
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17733322
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.15281718
75Attenuation of retinal blood vessels (HP:0007843)2.14889397
76Elevated erythrocyte sedimentation rate (HP:0003565)2.13959515
77Abnormality of DNA repair (HP:0003254)2.13885249
78Lymphoma (HP:0002665)2.13193397
79IgG deficiency (HP:0004315)2.12806689
80Abnormality of the phalanges of the 2nd finger (HP:0009541)2.12620492
81Stomach cancer (HP:0012126)2.11783822
82T lymphocytopenia (HP:0005403)2.10662887
83Eczematoid dermatitis (HP:0000976)2.10205380
84Abnormality of T cell number (HP:0011839)2.10192098
85Vasculitis (HP:0002633)2.09436060
86Orchitis (HP:0100796)2.08054661
87Chronic otitis media (HP:0000389)2.07673685
88Chronic diarrhea (HP:0002028)2.07292498
89Severe combined immunodeficiency (HP:0004430)2.07035710
90Meckel diverticulum (HP:0002245)2.06354807
91Periodontitis (HP:0000704)2.03848260
92Tubular atrophy (HP:0000092)2.02997891
93Hematochezia (HP:0002573)2.02953723
94Stomatitis (HP:0010280)2.02570750
95Hypoplasia of the thymus (HP:0000778)2.01178348
96Furrowed tongue (HP:0000221)2.00880163
97Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.00692734
98Polyuria (HP:0000103)1.99378299
99Abnormality of male internal genitalia (HP:0000022)1.99262870
100Recurrent pneumonia (HP:0006532)1.99250382
101Abnormality of eosinophils (HP:0001879)1.99132613
102Bilateral microphthalmos (HP:0007633)1.98447536
103Abnormality of the middle phalanges of the toes (HP:0010183)1.98429205
104Medial flaring of the eyebrow (HP:0010747)1.97851247
10511 pairs of ribs (HP:0000878)1.97783294
106Keratoconus (HP:0000563)1.97373130
107Increased corneal curvature (HP:0100692)1.97373130
108Chronic obstructive pulmonary disease (HP:0006510)1.96994137
109Obstructive lung disease (HP:0006536)1.96994137
110Chronic mucocutaneous candidiasis (HP:0002728)1.96977928
111Recurrent cutaneous fungal infections (HP:0011370)1.96977928
112Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.96548536
113Hypothermia (HP:0002045)1.95662551
114Abnormality of the ileum (HP:0001549)1.95540018
115Arterial thrombosis (HP:0004420)1.95459767
116Gaze-evoked nystagmus (HP:0000640)1.95269692
117Leukocytosis (HP:0001974)1.95149105
118Abnormal rod and cone electroretinograms (HP:0008323)1.94849082
119Abnormality of T cells (HP:0002843)1.94838286
120White forelock (HP:0002211)1.93234118
121Neoplasm of the tracheobronchial system (HP:0100552)1.92656662
122Type I transferrin isoform profile (HP:0003642)1.92516727
123Intestinal atresia (HP:0011100)1.92259682
124Methylmalonic aciduria (HP:0012120)1.92157137
125Lymphopenia (HP:0001888)1.91604897
126Abnormality of the 1st metacarpal (HP:0010009)1.91469054
127Keratoconjunctivitis sicca (HP:0001097)1.91099852
128Recurrent bronchitis (HP:0002837)1.90947338
129Abnormality of the frontal sinuses (HP:0002687)1.89544421
130Long eyelashes (HP:0000527)1.89202649
131Encephalitis (HP:0002383)1.88979927
132Petechiae (HP:0000967)1.88869136
133Bone marrow hypocellularity (HP:0005528)1.88300271
134Pulmonary fibrosis (HP:0002206)1.87816864
135Congenital hepatic fibrosis (HP:0002612)1.87568402
136Cellulitis (HP:0100658)1.87557626
137Ectropion (HP:0000656)1.86940503
138Clumsiness (HP:0002312)1.86060108
139Pulmonary infiltrates (HP:0002113)1.85842811
140Pancreatic fibrosis (HP:0100732)1.85839111
141Birth length less than 3rd percentile (HP:0003561)1.85577631
142Hypoproteinemia (HP:0003075)1.84842000
143True hermaphroditism (HP:0010459)1.83471834
144Chronic hepatic failure (HP:0100626)1.83434878
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82176784
146Abnormality of T cell physiology (HP:0011840)1.81541343
147Chorioretinal atrophy (HP:0000533)1.81115226
148Patchy hypopigmentation of hair (HP:0011365)1.81001615
149Abnormality of cells of the lymphoid lineage (HP:0012140)1.80829656
150Abnormality of the renal collecting system (HP:0004742)1.80748973
151Decreased central vision (HP:0007663)1.79112867
152Abnormal hair whorl (HP:0010721)1.78852785
153Amaurosis fugax (HP:0100576)1.78101076
154Recurrent skin infections (HP:0001581)1.77757266
155Decreased circulating renin level (HP:0003351)1.76980147
156Hyperglycinemia (HP:0002154)1.76638917
157Alveolar cell carcinoma (HP:0006519)1.76230159
158Ependymoma (HP:0002888)1.75857794
159Combined immunodeficiency (HP:0005387)1.75749512
160IgA deficiency (HP:0002720)1.75626376
161Small hand (HP:0200055)1.74322967
162Hamartoma of the eye (HP:0010568)1.73091754
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.71895898
164Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71318096
165Autoimmune hemolytic anemia (HP:0001890)1.69472901
166Enlarged kidneys (HP:0000105)1.68323910
167Fair hair (HP:0002286)1.68284862
168Adactyly (HP:0009776)1.65264206
169Glioma (HP:0009733)1.64043945
170Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63390345
171Long nose (HP:0003189)1.63241621
172Morphological abnormality of the middle ear (HP:0008609)1.63034125
173Hypochromic microcytic anemia (HP:0004840)1.61602943
174Abnormality of secondary sexual hair (HP:0009888)1.61477086
175Abnormality of the axillary hair (HP:0100134)1.61477086
176Sclerocornea (HP:0000647)1.61155502
177Aqueductal stenosis (HP:0002410)1.59739704
178Male pseudohermaphroditism (HP:0000037)1.59351428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.23647277
2IRAK43.12195219
3MAP3K143.10975655
4IRAK32.57048222
5MAP4K12.53208959
6ZAK2.42318789
7KIT2.27870068
8MAP4K22.27600785
9EIF2AK32.27464841
10TEC2.25228617
11WNK32.09197784
12BRD42.04232284
13PLK21.92730278
14TRIM281.82561982
15PLK41.82528872
16MKNK21.80398477
17IKBKE1.77243247
18TAOK31.75666519
19SRPK11.69002859
20FGFR21.68760997
21TRPM71.65615267
22TLK11.63574487
23VRK11.63152278
24MAPK131.62781034
25NUAK11.62533489
26IKBKB1.59866230
27BTK1.59027119
28BRSK21.58690143
29JAK31.58173172
30PIM11.50414181
31MKNK11.49868969
32YES11.47758276
33OXSR11.41755932
34CHUK1.39986220
35SGK21.38444586
36CSF1R1.34831594
37NLK1.34304956
38FRK1.27735270
39CDK121.26674141
40STK391.26244246
41SIK31.24400411
42FLT31.23149746
43BMPR21.22233867
44STK161.20042650
45STK41.19168467
46MUSK1.17269362
47EIF2AK21.15636469
48TYK21.13739492
49FGFR31.09080362
50CDK31.08385280
51TGFBR21.08060528
52ZAP701.06697361
53CLK11.05342179
54SYK1.04044484
55ATR1.02267429
56ERBB31.01194818
57CDC70.99814549
58CDK90.99563483
59NEK90.97285201
60ITK0.96001630
61MAPKAPK30.95440776
62EIF2AK10.94670323
63CDK80.90686845
64STK240.90620325
65PINK10.87812238
66WNK40.87388710
67LATS10.87339198
68TNIK0.87308563
69BUB10.85566392
70JAK10.85202112
71PRPF4B0.84040810
72LYN0.84011428
73NEK60.83812880
74BMPR1B0.82347735
75ACVR1B0.80164621
76SGK30.79354164
77ADRBK20.79307515
78RPS6KA40.78911176
79MST40.78849084
80STK30.78371202
81NEK20.78350384
82RIPK40.77421667
83TBK10.76565361
84MAP2K30.76197090
85LCK0.74853936
86IRAK10.72241546
87TNK20.71610400
88TGFBR10.71579453
89HIPK20.71063458
90CDK60.70170742
91ADRBK10.68359068
92MAP3K60.68115616
93HCK0.67577334
94WEE10.67383827
95INSRR0.67099221
96ATM0.64913203
97PRKCE0.64493264
98CSNK1G10.64370999
99PAK30.63605243
100FER0.62154017
101GRK10.61202982
102AURKB0.60978418
103MARK30.59579774
104PIK3CA0.59206574
105MAPK150.59136536
106ABL10.58929330
107BCKDK0.58766366
108STK100.58679934
109CHEK20.58114486
110BLK0.57822566
111MELK0.57678790
112CDK70.57218255
113AKT30.56487075
114CSNK1G20.55272080
115TIE10.55009662
116PRKCQ0.53701002
117RPS6KB10.53076698
118PLK30.52516310
119IRAK20.51818187
120CSNK1G30.51724922
121MAP3K130.50873375
122MATK0.50077115
123VRK20.49709532
124PIK3CG0.48624434
125GRK50.48419648
126RPS6KB20.48232502
127PLK10.47734435
128CSK0.47429195
129FES0.46794120
130BCR0.46658629
131DYRK30.46578115
132TAF10.45328069
133IGF1R0.44668162
134MAP3K40.42208227
135PTK2B0.41982025
136TTK0.41690783
137DAPK20.39520127
138PRKCI0.37753923
139STK38L0.35950733
140PHKG20.35212649
141PHKG10.35212649
142MAPKAPK50.34341640
143CSNK1A1L0.33960619
144GRK60.33570051
145PRKCG0.31772228
146CSNK1A10.30710799
147GRK70.28901852
148DYRK20.26194408
149STK110.22495121

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.42777144
2Primary immunodeficiency_Homo sapiens_hsa053402.36383643
3Nitrogen metabolism_Homo sapiens_hsa009102.33038415
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.30745378
5Non-homologous end-joining_Homo sapiens_hsa034502.22985682
6Phototransduction_Homo sapiens_hsa047442.22749302
7Homologous recombination_Homo sapiens_hsa034402.16078948
8DNA replication_Homo sapiens_hsa030302.07060413
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98726951
10Measles_Homo sapiens_hsa051621.94686860
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.92713601
12Mismatch repair_Homo sapiens_hsa034301.84819876
13Linoleic acid metabolism_Homo sapiens_hsa005911.84513491
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83212113
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82974155
16Herpes simplex infection_Homo sapiens_hsa051681.79399748
17Hematopoietic cell lineage_Homo sapiens_hsa046401.79161591
18Leishmaniasis_Homo sapiens_hsa051401.77035477
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75829454
20Proteasome_Homo sapiens_hsa030501.75808184
21Base excision repair_Homo sapiens_hsa034101.72439020
22Selenocompound metabolism_Homo sapiens_hsa004501.70805454
23Basal transcription factors_Homo sapiens_hsa030221.64691212
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.61618182
25Cell cycle_Homo sapiens_hsa041101.59888705
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57589361
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54781762
28Ether lipid metabolism_Homo sapiens_hsa005651.54059216
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51747344
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51435599
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.47808384
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47497130
33Propanoate metabolism_Homo sapiens_hsa006401.47449595
34B cell receptor signaling pathway_Homo sapiens_hsa046621.46536732
35Allograft rejection_Homo sapiens_hsa053301.45398783
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44769542
37Influenza A_Homo sapiens_hsa051641.42646159
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.39695332
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38104808
40* RNA degradation_Homo sapiens_hsa030181.35081196
41Osteoclast differentiation_Homo sapiens_hsa043801.34820271
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34227749
43Caffeine metabolism_Homo sapiens_hsa002321.28376565
44p53 signaling pathway_Homo sapiens_hsa041151.21656249
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21357190
46Butanoate metabolism_Homo sapiens_hsa006501.21236563
47Nucleotide excision repair_Homo sapiens_hsa034201.20363189
48Tryptophan metabolism_Homo sapiens_hsa003801.18560473
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17639290
50Antigen processing and presentation_Homo sapiens_hsa046121.16391031
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13120002
52Hepatitis B_Homo sapiens_hsa051611.12485894
53Peroxisome_Homo sapiens_hsa041461.11917734
54RNA polymerase_Homo sapiens_hsa030201.11639884
55Toxoplasmosis_Homo sapiens_hsa051451.10891550
56TNF signaling pathway_Homo sapiens_hsa046681.09888980
57Graft-versus-host disease_Homo sapiens_hsa053321.09192817
58T cell receptor signaling pathway_Homo sapiens_hsa046601.07737492
59Glycerolipid metabolism_Homo sapiens_hsa005611.06653143
60Spliceosome_Homo sapiens_hsa030401.05569361
61Olfactory transduction_Homo sapiens_hsa047401.04797748
62Regulation of autophagy_Homo sapiens_hsa041401.04207481
63mRNA surveillance pathway_Homo sapiens_hsa030151.02498452
64Acute myeloid leukemia_Homo sapiens_hsa052211.01859124
65Chemical carcinogenesis_Homo sapiens_hsa052041.01392918
66Dorso-ventral axis formation_Homo sapiens_hsa043200.99683480
67Pertussis_Homo sapiens_hsa051330.98475648
68Taste transduction_Homo sapiens_hsa047420.95262401
69Apoptosis_Homo sapiens_hsa042100.93460254
70One carbon pool by folate_Homo sapiens_hsa006700.92111920
71Small cell lung cancer_Homo sapiens_hsa052220.91903014
72MicroRNAs in cancer_Homo sapiens_hsa052060.91557897
73Autoimmune thyroid disease_Homo sapiens_hsa053200.91490266
74Pyrimidine metabolism_Homo sapiens_hsa002400.91403751
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91181900
76Epstein-Barr virus infection_Homo sapiens_hsa051690.89966499
77Legionellosis_Homo sapiens_hsa051340.88579403
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88458682
79Chemokine signaling pathway_Homo sapiens_hsa040620.86444952
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85381937
81HTLV-I infection_Homo sapiens_hsa051660.84785050
82Sulfur metabolism_Homo sapiens_hsa009200.83812362
83Other glycan degradation_Homo sapiens_hsa005110.83384964
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82699574
85Retinol metabolism_Homo sapiens_hsa008300.82516968
86Asthma_Homo sapiens_hsa053100.82386284
87Tuberculosis_Homo sapiens_hsa051520.81242059
88Notch signaling pathway_Homo sapiens_hsa043300.80477231
89Malaria_Homo sapiens_hsa051440.80297897
90Staphylococcus aureus infection_Homo sapiens_hsa051500.79822525
91Viral carcinogenesis_Homo sapiens_hsa052030.79498754
92Chronic myeloid leukemia_Homo sapiens_hsa052200.79047176
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77634336
94Pancreatic cancer_Homo sapiens_hsa052120.76500359
95Nicotine addiction_Homo sapiens_hsa050330.76435706
96Platelet activation_Homo sapiens_hsa046110.75414575
97Systemic lupus erythematosus_Homo sapiens_hsa053220.74389111
98Shigellosis_Homo sapiens_hsa051310.73330233
99Prostate cancer_Homo sapiens_hsa052150.71157343
100RNA transport_Homo sapiens_hsa030130.70540857
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69857827
102FoxO signaling pathway_Homo sapiens_hsa040680.69838459
103Thyroid cancer_Homo sapiens_hsa052160.69693922
104Hepatitis C_Homo sapiens_hsa051600.69575782
105Sphingolipid metabolism_Homo sapiens_hsa006000.68509065
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67950163
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67771011
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67440205
109Serotonergic synapse_Homo sapiens_hsa047260.66808142
110Morphine addiction_Homo sapiens_hsa050320.66257065
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.65305577
112Prolactin signaling pathway_Homo sapiens_hsa049170.65198679
113Salmonella infection_Homo sapiens_hsa051320.63823713
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.63216722
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.61096320
116Purine metabolism_Homo sapiens_hsa002300.60971806
117Ribosome_Homo sapiens_hsa030100.58131942
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57339591
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56927707
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56924981
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56265797
122Circadian entrainment_Homo sapiens_hsa047130.55907353
123Fat digestion and absorption_Homo sapiens_hsa049750.55796377
124Non-small cell lung cancer_Homo sapiens_hsa052230.53753014
125Colorectal cancer_Homo sapiens_hsa052100.52484045
126Lysine degradation_Homo sapiens_hsa003100.51524908
127Arachidonic acid metabolism_Homo sapiens_hsa005900.51469930
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.51453775
129Inositol phosphate metabolism_Homo sapiens_hsa005620.51243798
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50953988
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50002320
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49901719
133Pathways in cancer_Homo sapiens_hsa052000.49754342
134Rheumatoid arthritis_Homo sapiens_hsa053230.49328215
135African trypanosomiasis_Homo sapiens_hsa051430.49074165
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47849016
137Renin secretion_Homo sapiens_hsa049240.47478464
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.46776415
139Type I diabetes mellitus_Homo sapiens_hsa049400.46568450
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.46134554
141Protein export_Homo sapiens_hsa030600.45703498
142Adherens junction_Homo sapiens_hsa045200.43670348
143TGF-beta signaling pathway_Homo sapiens_hsa043500.43618612
144Salivary secretion_Homo sapiens_hsa049700.42365753
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42326173
146Viral myocarditis_Homo sapiens_hsa054160.42323014
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40404937
148Vitamin digestion and absorption_Homo sapiens_hsa049770.40364148
149ABC transporters_Homo sapiens_hsa020100.39444852
150Calcium signaling pathway_Homo sapiens_hsa040200.39396834
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37444870
152Collecting duct acid secretion_Homo sapiens_hsa049660.35979431
153Fatty acid elongation_Homo sapiens_hsa000620.34248097
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31636684
155Oocyte meiosis_Homo sapiens_hsa041140.31335196
156Oxidative phosphorylation_Homo sapiens_hsa001900.31202080
157Metabolic pathways_Homo sapiens_hsa011000.30712018

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