PANK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.30491606
2L-phenylalanine catabolic process (GO:0006559)7.30491606
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.00458507
4L-phenylalanine metabolic process (GO:0006558)7.00458507
5aromatic amino acid family catabolic process (GO:0009074)6.64453962
6tryptophan catabolic process (GO:0006569)6.06527615
7indole-containing compound catabolic process (GO:0042436)6.06527615
8indolalkylamine catabolic process (GO:0046218)6.06527615
9glyoxylate metabolic process (GO:0046487)5.99131422
10kynurenine metabolic process (GO:0070189)5.87570956
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.80785390
12bile acid biosynthetic process (GO:0006699)5.74912899
13tryptophan metabolic process (GO:0006568)5.72735708
14alpha-linolenic acid metabolic process (GO:0036109)5.62266724
15cysteine metabolic process (GO:0006534)5.51856055
16lysine metabolic process (GO:0006553)5.33330658
17lysine catabolic process (GO:0006554)5.33330658
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.25916719
19urea metabolic process (GO:0019627)5.22659309
20urea cycle (GO:0000050)5.22659309
21sulfur amino acid catabolic process (GO:0000098)5.18353442
22serine family amino acid catabolic process (GO:0009071)5.12089919
23high-density lipoprotein particle remodeling (GO:0034375)5.02577562
24negative regulation of fibrinolysis (GO:0051918)5.00364229
25amino-acid betaine metabolic process (GO:0006577)4.91860447
26protein carboxylation (GO:0018214)4.89942565
27peptidyl-glutamic acid carboxylation (GO:0017187)4.89942565
28bile acid metabolic process (GO:0008206)4.87883040
29aromatic amino acid family metabolic process (GO:0009072)4.83147651
30regulation of fibrinolysis (GO:0051917)4.83043903
31nitrogen cycle metabolic process (GO:0071941)4.82530497
32homocysteine metabolic process (GO:0050667)4.82392074
33cellular ketone body metabolic process (GO:0046950)4.77917074
34complement activation, alternative pathway (GO:0006957)4.76099815
35regulation of protein activation cascade (GO:2000257)4.70830094
36alpha-amino acid catabolic process (GO:1901606)4.66227847
37regulation of triglyceride catabolic process (GO:0010896)4.63769854
38tyrosine metabolic process (GO:0006570)4.53630088
39regulation of cholesterol esterification (GO:0010872)4.42052630
40regulation of complement activation (GO:0030449)4.38130539
41triglyceride homeostasis (GO:0070328)4.35743306
42acylglycerol homeostasis (GO:0055090)4.35743306
43cellular amino acid catabolic process (GO:0009063)4.35156080
44reverse cholesterol transport (GO:0043691)4.34919787
45short-chain fatty acid metabolic process (GO:0046459)4.33929113
46protein-lipid complex remodeling (GO:0034368)4.33467403
47macromolecular complex remodeling (GO:0034367)4.33467403
48plasma lipoprotein particle remodeling (GO:0034369)4.33467403
49coenzyme catabolic process (GO:0009109)4.32901600
50indolalkylamine metabolic process (GO:0006586)4.29455770
51glutamate metabolic process (GO:0006536)4.27881266
52negative regulation of cholesterol transport (GO:0032375)4.27156304
53negative regulation of sterol transport (GO:0032372)4.27156304
54serine family amino acid metabolic process (GO:0009069)4.27075692
55benzene-containing compound metabolic process (GO:0042537)4.23634858
56ethanol oxidation (GO:0006069)4.22932367
57drug catabolic process (GO:0042737)4.21503224
58glycine metabolic process (GO:0006544)4.20123748
59cellular glucuronidation (GO:0052695)4.17016797
60amine catabolic process (GO:0009310)4.15285383
61cellular biogenic amine catabolic process (GO:0042402)4.15285383
62L-serine metabolic process (GO:0006563)4.14777261
63phospholipid efflux (GO:0033700)4.14537197
64ketone body metabolic process (GO:1902224)4.13685744
65drug transmembrane transport (GO:0006855)4.13045710
66acetyl-CoA metabolic process (GO:0006084)4.12989951
67cellular modified amino acid catabolic process (GO:0042219)4.12716040
68bile acid and bile salt transport (GO:0015721)4.08634622
69fatty acid beta-oxidation (GO:0006635)4.05104348
70serine family amino acid biosynthetic process (GO:0009070)4.02791486
71plasma lipoprotein particle clearance (GO:0034381)4.01789013
72urate metabolic process (GO:0046415)3.98011507
73fatty acid oxidation (GO:0019395)3.96541981
74organic acid catabolic process (GO:0016054)3.95538935
75carboxylic acid catabolic process (GO:0046395)3.95538935
76aspartate family amino acid catabolic process (GO:0009068)3.94992795
77imidazole-containing compound metabolic process (GO:0052803)3.94887595
78dicarboxylic acid biosynthetic process (GO:0043650)3.91945340
79lipid oxidation (GO:0034440)3.89136028
80monocarboxylic acid catabolic process (GO:0072329)3.86375447
81carnitine metabolic process (GO:0009437)3.85365881
82aldehyde catabolic process (GO:0046185)3.84183696
83fatty acid catabolic process (GO:0009062)3.82999684
842-oxoglutarate metabolic process (GO:0006103)3.82870002
85cholesterol efflux (GO:0033344)3.79756158
86uronic acid metabolic process (GO:0006063)3.76046517
87glucuronate metabolic process (GO:0019585)3.76046517
88arginine metabolic process (GO:0006525)3.75958256
89exogenous drug catabolic process (GO:0042738)3.69580951
90negative regulation of lipase activity (GO:0060192)3.68996846
91positive regulation of lipid catabolic process (GO:0050996)3.67553202
92plasma lipoprotein particle assembly (GO:0034377)3.64577712
93low-density lipoprotein particle remodeling (GO:0034374)3.63950212
94phospholipid homeostasis (GO:0055091)3.62314144
95cofactor catabolic process (GO:0051187)3.61763184
96positive regulation of fatty acid beta-oxidation (GO:0032000)3.61239153
97regulation of gene silencing by RNA (GO:0060966)3.60982928
98regulation of posttranscriptional gene silencing (GO:0060147)3.60982928
99regulation of gene silencing by miRNA (GO:0060964)3.60982928
100regulation of cholesterol homeostasis (GO:2000188)3.60685885
101fibrinolysis (GO:0042730)3.60508583
102regulation of bile acid biosynthetic process (GO:0070857)3.59446484
103cholesterol homeostasis (GO:0042632)3.55806057
104flavonoid metabolic process (GO:0009812)3.55034149
105epoxygenase P450 pathway (GO:0019373)3.38698734
106chromatin remodeling at centromere (GO:0031055)3.33403496
107somatic hypermutation of immunoglobulin genes (GO:0016446)3.18461959
108somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18461959
109CENP-A containing nucleosome assembly (GO:0034080)3.09313070
110omega-hydroxylase P450 pathway (GO:0097267)3.05521800
111regulation of helicase activity (GO:0051095)3.03055776
112water-soluble vitamin biosynthetic process (GO:0042364)2.86363817
113DNA double-strand break processing (GO:0000729)2.84190237
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.82646171
115DNA replication checkpoint (GO:0000076)2.76345194
116DNA damage response, detection of DNA damage (GO:0042769)2.76338152
117oxidative demethylation (GO:0070989)2.72100783
118pre-miRNA processing (GO:0031054)2.69713839
119pyrimidine nucleobase catabolic process (GO:0006208)2.67979679
120histone exchange (GO:0043486)2.67866336
121kinetochore organization (GO:0051383)2.61062830
122presynaptic membrane assembly (GO:0097105)2.60711466
123heterochromatin organization (GO:0070828)2.58046768
124regulation of translation, ncRNA-mediated (GO:0045974)2.57208072
125negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57208072
126negative regulation of translation, ncRNA-mediated (GO:0040033)2.57208072
127drug metabolic process (GO:0017144)2.56622834
128establishment of integrated proviral latency (GO:0075713)2.55924367
129DNA replication-independent nucleosome organization (GO:0034724)2.51250495
130DNA replication-independent nucleosome assembly (GO:0006336)2.51250495
131regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.50732009
132C4-dicarboxylate transport (GO:0015740)2.47164783
133negative regulation of astrocyte differentiation (GO:0048712)2.46699066
134protein localization to kinetochore (GO:0034501)2.42005874
135cholesterol biosynthetic process (GO:0006695)2.39760208
136replication fork processing (GO:0031297)2.39735609
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39326548
138regulation of mitotic spindle checkpoint (GO:1903504)2.39326548
139anterior/posterior axis specification, embryo (GO:0008595)2.38742437
140S-adenosylmethionine metabolic process (GO:0046500)2.38442634
141nucleobase catabolic process (GO:0046113)2.37952240
142regulation of nuclear cell cycle DNA replication (GO:0033262)2.36111305
143kinetochore assembly (GO:0051382)2.34890984
144purine nucleobase biosynthetic process (GO:0009113)2.32594857
145mitotic G2/M transition checkpoint (GO:0044818)2.29974741
146DNA strand elongation involved in DNA replication (GO:0006271)2.29641713
147dorsal/ventral axis specification (GO:0009950)2.29611025
148presynaptic membrane organization (GO:0097090)2.29291734
149nucleobase biosynthetic process (GO:0046112)2.28321065
150regulation of centriole replication (GO:0046599)2.27618368
151otic vesicle formation (GO:0030916)2.25309883
152regulation of non-canonical Wnt signaling pathway (GO:2000050)2.25008667
153amino acid salvage (GO:0043102)2.23692591
154L-methionine salvage (GO:0071267)2.23692591
155L-methionine biosynthetic process (GO:0071265)2.23692591
156sterol biosynthetic process (GO:0016126)2.22665547
157mitotic metaphase plate congression (GO:0007080)2.21374778
158maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.17770738
159DNA strand elongation (GO:0022616)2.16757792
160ethanol metabolic process (GO:0006067)2.16679753
161notochord development (GO:0030903)2.14711511
162lateral sprouting from an epithelium (GO:0060601)2.13408240
163ncRNA catabolic process (GO:0034661)2.13338940
164negative regulation of DNA recombination (GO:0045910)2.13092433
165heme transport (GO:0015886)2.12101145
166regulation of DNA endoreduplication (GO:0032875)2.10949115
167metaphase plate congression (GO:0051310)2.10059552
168regulation of centrosome cycle (GO:0046605)2.09676218
169vitamin biosynthetic process (GO:0009110)2.08947374
170paraxial mesoderm development (GO:0048339)2.08888232
171DNA ligation (GO:0006266)2.08592787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.20936392
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.04902077
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.62744381
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.40508492
5* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.52632894
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.14054795
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.77472987
8E2F7_22180533_ChIP-Seq_HELA_Human4.72835988
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.96832226
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.76100515
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.97639943
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.77113926
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55995965
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46726559
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41242131
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36856206
17FUS_26573619_Chip-Seq_HEK293_Human2.35006326
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34288515
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.26959107
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20608842
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.11475753
22IGF1R_20145208_ChIP-Seq_DFB_Human2.10150511
23* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06630332
24EWS_26573619_Chip-Seq_HEK293_Human2.06491278
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04960280
26* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6075193
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.98137440
28ZNF274_21170338_ChIP-Seq_K562_Hela1.97503361
29GBX2_23144817_ChIP-Seq_PC3_Human1.86150127
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83164209
31AR_21909140_ChIP-Seq_LNCAP_Human1.79652287
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77570808
33CLOCK_20551151_ChIP-Seq_293T_Human1.75361105
34P300_19829295_ChIP-Seq_ESCs_Human1.72391231
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68613940
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.66151927
37VDR_22108803_ChIP-Seq_LS180_Human1.59600971
38* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59550474
39* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59182612
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.54117187
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53332928
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52600855
43NANOG_16153702_ChIP-ChIP_HESCs_Human1.50033928
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46027127
45* MYC_18940864_ChIP-ChIP_HL60_Human1.44999681
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41345706
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.40343595
48HTT_18923047_ChIP-ChIP_STHdh_Human1.40080074
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.39133754
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37969626
51GATA1_22025678_ChIP-Seq_K562_Human1.36993904
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34823632
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.34710771
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31945894
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31497200
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30935827
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.30319505
58IRF1_19129219_ChIP-ChIP_H3396_Human1.28391442
59* ELK1_19687146_ChIP-ChIP_HELA_Human1.27050688
60EZH2_22144423_ChIP-Seq_EOC_Human1.26422663
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26075474
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24720376
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23279778
64TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22370663
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.21383110
66TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21016005
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19974963
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18955671
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17946000
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.16812342
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16613234
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14104363
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13627585
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12132242
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11486687
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11486687
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11066696
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09606984
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09210659
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07672674
81RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07402294
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07286135
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06606204
84SMAD4_21799915_ChIP-Seq_A2780_Human1.04691201
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03419099
86TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02700515
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02668701
88* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02350004
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02280234
90MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02093067
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01871429
92ER_23166858_ChIP-Seq_MCF-7_Human1.01867618
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01686642
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01617035
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00837148
96CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00814213
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00347630
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.99724372
99POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99379817
100SOX9_26525672_Chip-Seq_HEART_Mouse0.98806920
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98687209
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97727474
103PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97693094
104KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97583560
105* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96992495
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96381546
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96202644
108CBP_20019798_ChIP-Seq_JUKART_Human0.96202644
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93999140
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93685593
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.93316169
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92539248
113STAT3_23295773_ChIP-Seq_U87_Human0.92477519
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91969195
115TCF4_22108803_ChIP-Seq_LS180_Human0.91756852
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91305982
117MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90475405
118GATA4_25053715_ChIP-Seq_YYC3_Human0.90305178
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90239210
120AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89779932
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89710194
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88815847
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87919693
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87881212
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84116365
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79936508
127ZNF263_19887448_ChIP-Seq_K562_Human0.79286227
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76357792
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76131279
130ESR2_21235772_ChIP-Seq_MCF-7_Human0.75493853
131KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74667957
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73519430
133* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.71200857
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70393723
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70205520
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70205520
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69115910
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.67174757
139BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66142959
140Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65987073
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64699120
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63514093
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.61876168
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.61247921
145* CEBPB_22108803_ChIP-Seq_LS180_Human0.60986304
146BCAT_22108803_ChIP-Seq_LS180_Human0.60974268
147TAF15_26573619_Chip-Seq_HEK293_Human0.58916630
148AR_20517297_ChIP-Seq_VCAP_Human0.58760661
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57949502
150EGR1_19032775_ChIP-ChIP_M12_Human0.56879215
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.56634208
152FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56588953
153FOXA1_25552417_ChIP-Seq_VCAP_Human0.56027976
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.54995464
155STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54209851
156IRF8_22096565_ChIP-ChIP_GC-B_Human0.54113856
157PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53162474
158RARB_24833708_ChIP-Seq_LIVER_Mouse0.52558232
159PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52242088
160FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.52031652
161* CBP_21632823_ChIP-Seq_H3396_Human0.51882059
162ESET_19884257_ChIP-Seq_ESCs_Mouse0.51783670
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.50635828
164STAT1_17558387_ChIP-Seq_HELA_Human0.49921887
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.49789352
166MYC_19915707_ChIP-ChIP_AK7_Human0.49630062
167NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.49593094
168* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48822289
169EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.48122142
170NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.45940398
171LXR_22292898_ChIP-Seq_THP-1_Human0.45664567
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45442420
173GATA6_25053715_ChIP-Seq_YYC3_Human0.44251583
174TBX20_22080862_ChIP-Seq_HEART_Mouse0.43981540
175TBX20_22328084_ChIP-Seq_HEART_Mouse0.43981540
176TAF2_19829295_ChIP-Seq_ESCs_Human0.43628965
177CDX2_22108803_ChIP-Seq_LS180_Human0.43307770
178GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.41941372
179GATA2_19941826_ChIP-Seq_K562_Human0.41696159
180* P53_21459846_ChIP-Seq_SAOS-2_Human0.41579047
181ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.40105805
182CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40081864
183ERG_20517297_ChIP-Seq_VCAP_Human0.39854967
184* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39669636
185PIAS1_25552417_ChIP-Seq_VCAP_Human0.38846906
186ERG_21242973_ChIP-ChIP_JURKAT_Human0.38540631
187GATA1_19941826_ChIP-Seq_K562_Human0.38263990
188SOX2_20726797_ChIP-Seq_SW620_Human0.37999492
189SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37400364
190FOXH1_21741376_ChIP-Seq_EPCs_Human0.36646742
191GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.35894162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.27844226
2MP0005360_urolithiasis7.63420815
3MP0005085_abnormal_gallbladder_physiolo6.25537636
4MP0005365_abnormal_bile_salt6.04151596
5MP0008875_abnormal_xenobiotic_pharmacok5.07642341
6MP0003806_abnormal_nucleotide_metabolis4.02537802
7MP0003252_abnormal_bile_duct3.88452288
8MP0010329_abnormal_lipoprotein_level3.44821006
9MP0003195_calcinosis3.08969097
10* MP0005332_abnormal_amino_acid3.05077413
11MP0006292_abnormal_olfactory_placode3.03963222
12MP0009840_abnormal_foam_cell2.87045904
13MP0005083_abnormal_biliary_tract2.80797739
14MP0001666_abnormal_nutrient_absorption2.46689651
15MP0004019_abnormal_vitamin_homeostasis2.44353540
16MP0000566_synostosis2.44348845
17MP0003890_abnormal_embryonic-extraembry2.43741187
18MP0003693_abnormal_embryo_hatching2.35969456
19MP0001293_anophthalmia2.34413035
20MP0003191_abnormal_cellular_cholesterol2.12349930
21* MP0002118_abnormal_lipid_homeostasis2.12114148
22MP0002138_abnormal_hepatobiliary_system2.11163125
23MP0010094_abnormal_chromosome_stability2.08439804
24* MP0000609_abnormal_liver_physiology2.06616176
25MP0002938_white_spotting2.00935603
26MP0005319_abnormal_enzyme/_coenzyme1.86045525
27MP0009379_abnormal_foot_pigmentation1.84095723
28MP0003941_abnormal_skin_development1.80393327
29MP0004957_abnormal_blastocyst_morpholog1.74666077
30MP0008058_abnormal_DNA_repair1.72094277
31MP0003868_abnormal_feces_composition1.71657112
32MP0003567_abnormal_fetal_cardiomyocyte1.68466768
33MP0003119_abnormal_digestive_system1.64010631
34MP0003122_maternal_imprinting1.62981215
35MP0003937_abnormal_limbs/digits/tail_de1.61837776
36* MP0005584_abnormal_enzyme/coenzyme_acti1.61159092
37MP0004133_heterotaxia1.59554815
38MP0005451_abnormal_body_composition1.59421052
39MP0001764_abnormal_homeostasis1.58052714
40MP0009643_abnormal_urine_homeostasis1.54010881
41MP0003136_yellow_coat_color1.52670600
42MP0004147_increased_porphyrin_level1.47316052
43MP0003011_delayed_dark_adaptation1.46747946
44MP0002233_abnormal_nose_morphology1.46745163
45MP0002697_abnormal_eye_size1.46561279
46MP0009697_abnormal_copulation1.41055503
47MP0003111_abnormal_nucleus_morphology1.39838180
48MP0010030_abnormal_orbit_morphology1.38105121
49MP0008877_abnormal_DNA_methylation1.35868330
50MP0003186_abnormal_redox_activity1.35608834
51MP0003880_abnormal_central_pattern1.33823028
52MP0001286_abnormal_eye_development1.31977114
53MP0004145_abnormal_muscle_electrophysio1.29606891
54MP0005187_abnormal_penis_morphology1.29534926
55MP0003121_genomic_imprinting1.29364065
56MP0008057_abnormal_DNA_replication1.28267079
57MP0005670_abnormal_white_adipose1.27494857
58MP0008932_abnormal_embryonic_tissue1.24759749
59MP0006072_abnormal_retinal_apoptosis1.23735349
60MP0001188_hyperpigmentation1.23175365
61MP0003787_abnormal_imprinting1.15724265
62MP0005636_abnormal_mineral_homeostasis1.15153846
63MP0000631_abnormal_neuroendocrine_gland1.14972848
64MP0006036_abnormal_mitochondrial_physio1.14891211
65MP0000049_abnormal_middle_ear1.14500308
66MP0000778_abnormal_nervous_system1.14224480
67MP0001485_abnormal_pinna_reflex1.14173928
68MP0001529_abnormal_vocalization1.13976717
69MP0002234_abnormal_pharynx_morphology1.13560441
70MP0000428_abnormal_craniofacial_morphol1.13475827
71MP0005647_abnormal_sex_gland1.11260943
72MP0000598_abnormal_liver_morphology1.10231847
73MP0003077_abnormal_cell_cycle1.09633896
74MP0008789_abnormal_olfactory_epithelium1.06108327
75MP0000537_abnormal_urethra_morphology1.04889895
76MP0001299_abnormal_eye_distance/1.01720333
77MP0003938_abnormal_ear_development1.01674141
78MP0003656_abnormal_erythrocyte_physiolo1.01639433
79MP0004270_analgesia1.01556310
80MP0005551_abnormal_eye_electrophysiolog1.01092753
81MP0003861_abnormal_nervous_system1.00685828
82MP0002111_abnormal_tail_morphology0.99123775
83MP0003315_abnormal_perineum_morphology0.98549918
84MP0003705_abnormal_hypodermis_morpholog0.97266829
85MP0004130_abnormal_muscle_cell0.97104245
86MP0009764_decreased_sensitivity_to0.96750574
87MP0002971_abnormal_brown_adipose0.96303782
88MP0002092_abnormal_eye_morphology0.94917353
89MP0000604_amyloidosis0.94510122
90MP0002084_abnormal_developmental_patter0.94002554
91MP0002085_abnormal_embryonic_tissue0.93821800
92MP0003755_abnormal_palate_morphology0.92739821
93MP0009763_increased_sensitivity_to0.91936904
94MP0009703_decreased_birth_body0.91059970
95MP0002102_abnormal_ear_morphology0.90892780
96MP0004043_abnormal_pH_regulation0.90646318
97MP0002638_abnormal_pupillary_reflex0.89588289
98MP0005535_abnormal_body_temperature0.88346429
99* MP0009642_abnormal_blood_homeostasis0.87766725
100MP0002254_reproductive_system_inflammat0.87203297
101MP0004215_abnormal_myocardial_fiber0.85896730
102MP0006276_abnormal_autonomic_nervous0.84887481
103MP0005391_vision/eye_phenotype0.84871059
104MP0004197_abnormal_fetal_growth/weight/0.83161485
105* MP0002078_abnormal_glucose_homeostasis0.82810901
106MP0002876_abnormal_thyroid_physiology0.82757128
107MP0005408_hypopigmentation0.82522602
108MP0001756_abnormal_urination0.82514162
109MP0002736_abnormal_nociception_after0.82154675
110MP0005084_abnormal_gallbladder_morpholo0.81491456
111MP0003646_muscle_fatigue0.81402452
112MP0001661_extended_life_span0.80534256
113MP0008469_abnormal_protein_level0.80150925
114MP0010368_abnormal_lymphatic_system0.79606561
115MP0005666_abnormal_adipose_tissue0.78980753
116MP0002837_dystrophic_cardiac_calcinosis0.78640978
117MP0005394_taste/olfaction_phenotype0.77605835
118MP0005499_abnormal_olfactory_system0.77605835
119MP0005377_hearing/vestibular/ear_phenot0.76414391
120MP0003878_abnormal_ear_physiology0.76414391
121MP0001672_abnormal_embryogenesis/_devel0.76361458
122MP0005380_embryogenesis_phenotype0.76361458
123MP0005376_homeostasis/metabolism_phenot0.76256403
124MP0004885_abnormal_endolymph0.76148436
125MP0001984_abnormal_olfaction0.76105177
126MP0005334_abnormal_fat_pad0.75677394
127MP0001730_embryonic_growth_arrest0.75560828
128MP0000647_abnormal_sebaceous_gland0.75204513
129MP0006035_abnormal_mitochondrial_morpho0.74540470
130MP0003123_paternal_imprinting0.74444539
131MP0005195_abnormal_posterior_eye0.72807863
132MP0001697_abnormal_embryo_size0.71416738
133MP0009765_abnormal_xenobiotic_induced0.69854969
134MP0005266_abnormal_metabolism0.69429632
135MP0003935_abnormal_craniofacial_develop0.68356555
136MP0000462_abnormal_digestive_system0.67501701
137MP0002751_abnormal_autonomic_nervous0.67393863
138MP0002136_abnormal_kidney_physiology0.67348246
139MP0005220_abnormal_exocrine_pancreas0.66158003
140MP0003329_amyloid_beta_deposits0.62916525
141MP0003690_abnormal_glial_cell0.60529155
142MP0002796_impaired_skin_barrier0.58014808
143MP0005448_abnormal_energy_balance0.57388625
144MP0001765_abnormal_ion_homeostasis0.51861607
145MP0009053_abnormal_anal_canal0.51324570
146MP0002928_abnormal_bile_duct0.50496257
147MP0003638_abnormal_response/metabolism_0.50108589
148MP0000230_abnormal_systemic_arterial0.49762347
149MP0005395_other_phenotype0.47358440
150MP0003953_abnormal_hormone_level0.47270889
151MP0000639_abnormal_adrenal_gland0.47011501
152MP0004381_abnormal_hair_follicle0.42455261
153MP0009115_abnormal_fat_cell0.41599483
154MP0008872_abnormal_physiological_respon0.41125502
155MP0008874_decreased_physiological_sensi0.40743562
156MP0002970_abnormal_white_adipose0.40118048
157MP0003724_increased_susceptibility_to0.40108288
158MP0002168_other_aberrant_phenotype0.39412952
159MP0005330_cardiomyopathy0.39300228
160MP0009672_abnormal_birth_weight0.38684360
161MP0004782_abnormal_surfactant_physiolog0.38193452
162MP0002822_catalepsy0.36657268
163MP0008873_increased_physiological_sensi0.35948828
164MP0009384_cardiac_valve_regurgitation0.35868435
165MP0003718_maternal_effect0.33663878
166MP0005464_abnormal_platelet_physiology0.31517371
167MP0005248_abnormal_Harderian_gland0.31219749
168MP0004185_abnormal_adipocyte_glucose0.30288724
169MP0001853_heart_inflammation0.29890208
170MP0000579_abnormal_nail_morphology0.29243783
171MP0003959_abnormal_lean_body0.28107524
172MP0002269_muscular_atrophy0.27800536
173MP0005166_decreased_susceptibility_to0.27207289
174MP0005375_adipose_tissue_phenotype0.27176569
175MP0005058_abnormal_lysosome_morphology0.27163400
176MP0002135_abnormal_kidney_morphology0.26533066
177MP0003075_altered_response_to0.26036970
178MP0000538_abnormal_urinary_bladder0.25975758
179MP0001881_abnormal_mammary_gland0.25285412

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.88206449
2Intrahepatic cholestasis (HP:0001406)6.77105347
3Deep venous thrombosis (HP:0002625)6.56340330
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.01154195
5Xanthomatosis (HP:0000991)5.89424542
6Hypobetalipoproteinemia (HP:0003563)5.77137396
7Prolonged partial thromboplastin time (HP:0003645)5.75337792
8Hyperlipoproteinemia (HP:0010980)5.03209742
9Hyperammonemia (HP:0001987)4.83453392
10Ketosis (HP:0001946)4.70065047
11Hyperglycinemia (HP:0002154)4.69145484
12Hyperglycinuria (HP:0003108)4.68539633
13Complement deficiency (HP:0004431)4.58528208
14Abnormality of serine family amino acid metabolism (HP:0010894)4.51053555
15Abnormality of glycine metabolism (HP:0010895)4.51053555
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.39928797
17Hypolipoproteinemia (HP:0010981)4.39108709
18Hypoglycemic coma (HP:0001325)4.27210790
19Epidermoid cyst (HP:0200040)4.22981299
20Joint hemorrhage (HP:0005261)4.22107622
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.21939708
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.05581041
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.02342882
24Abnormality of fatty-acid metabolism (HP:0004359)3.99610852
25Abnormality of methionine metabolism (HP:0010901)3.92919098
26Abnormality of the common coagulation pathway (HP:0010990)3.92121949
27Hypoalphalipoproteinemia (HP:0003233)3.89318278
28Colon cancer (HP:0003003)3.87380518
29Fat malabsorption (HP:0002630)3.79101651
30Ketoacidosis (HP:0001993)3.71266977
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.57078866
32Conjugated hyperbilirubinemia (HP:0002908)3.47080314
33Abnormality of pyrimidine metabolism (HP:0004353)3.39700483
34Delayed CNS myelination (HP:0002188)3.33657404
35Hypercholesterolemia (HP:0003124)3.31814169
36Abnormality of the intrinsic pathway (HP:0010989)3.28324685
37Abnormality of complement system (HP:0005339)3.27386974
38Dicarboxylic aciduria (HP:0003215)3.24044764
39Abnormality of dicarboxylic acid metabolism (HP:0010995)3.24044764
40Abnormality of serum amino acid levels (HP:0003112)3.23721123
41Hyperbilirubinemia (HP:0002904)3.20538374
42Abnormality of nucleobase metabolism (HP:0010932)3.20475593
43Hepatoblastoma (HP:0002884)3.17606624
44Gout (HP:0001997)3.11548972
45Abnormality of purine metabolism (HP:0004352)3.10863148
46Metabolic acidosis (HP:0001942)3.08663300
47Septo-optic dysplasia (HP:0100842)3.06770188
48Lethargy (HP:0001254)2.98392344
49Generalized aminoaciduria (HP:0002909)2.94131447
50Cerebral edema (HP:0002181)2.88581245
51Hepatocellular carcinoma (HP:0001402)2.82120771
52Steatorrhea (HP:0002570)2.79802259
53Vascular calcification (HP:0004934)2.74428389
54Abnormality of the labia minora (HP:0012880)2.67004143
55Proximal tubulopathy (HP:0000114)2.61803416
56Skin nodule (HP:0200036)2.60053727
57Chromsome breakage (HP:0040012)2.54663085
58Spontaneous abortion (HP:0005268)2.53873943
59Myocardial infarction (HP:0001658)2.53075850
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52260922
61Hypoglycemic seizures (HP:0002173)2.46691661
62Hypochromic microcytic anemia (HP:0004840)2.45989824
63Vomiting (HP:0002013)2.45986839
64Spastic diplegia (HP:0001264)2.45535849
65Cardiovascular calcification (HP:0011915)2.42674659
66Irritability (HP:0000737)2.39818780
67Medulloblastoma (HP:0002885)2.39628384
68Alkalosis (HP:0001948)2.36626243
69Malnutrition (HP:0004395)2.34611872
70Neonatal onset (HP:0003623)2.33793826
71Renal cortical cysts (HP:0000803)2.31828922
72Abnormality of urine glucose concentration (HP:0011016)2.30597545
73Glycosuria (HP:0003076)2.30597545
74Hyperuricemia (HP:0002149)2.30326069
75Increased purine levels (HP:0004368)2.30326069
76Enlarged kidneys (HP:0000105)2.27687693
77Abnormal gallbladder morphology (HP:0012437)2.25978541
78Systemic lupus erythematosus (HP:0002725)2.24136471
79Acanthocytosis (HP:0001927)2.24109845
80Brushfield spots (HP:0001088)2.23358737
81Late onset (HP:0003584)2.23300829
82Abnormal lung lobation (HP:0002101)2.23227872
83Hydroxyprolinuria (HP:0003080)2.22338309
84Abnormality of proline metabolism (HP:0010907)2.22338309
85Meckel diverticulum (HP:0002245)2.22286388
86Glioma (HP:0009733)2.22029867
87Cholelithiasis (HP:0001081)2.21841489
88Sensorimotor neuropathy (HP:0007141)2.21127131
89Increased serum pyruvate (HP:0003542)2.19424249
90Pancreatitis (HP:0001733)2.18855459
91Abnormality of the ileum (HP:0001549)2.16815232
92Cholecystitis (HP:0001082)2.16182250
93Abnormal gallbladder physiology (HP:0012438)2.16182250
94Optic nerve hypoplasia (HP:0000609)2.13880156
95Megaloblastic anemia (HP:0001889)2.09149950
96Hyperinsulinemic hypoglycemia (HP:0000825)2.08053855
97Mitral stenosis (HP:0001718)2.07010569
98Rickets (HP:0002748)2.06663165
99Impulsivity (HP:0100710)2.06187644
100Maternal diabetes (HP:0009800)2.05856732
101Glomerulonephritis (HP:0000099)2.03754490
102Abnormality of chromosome stability (HP:0003220)2.02051320
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01355835
104Absent septum pellucidum (HP:0001331)2.00399144
105Abnormal cartilage morphology (HP:0002763)2.00395121
106Bilateral microphthalmos (HP:0007633)1.99415119
107Nausea (HP:0002018)1.99166536
108Nephroblastoma (Wilms tumor) (HP:0002667)1.98328106
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.98086896
110Esophageal varix (HP:0002040)1.95434011
111Opisthotonus (HP:0002179)1.92784670
112Esophageal atresia (HP:0002032)1.92624824
113Acute encephalopathy (HP:0006846)1.92416502
114Anophthalmia (HP:0000528)1.92226584
115Embryonal renal neoplasm (HP:0011794)1.88540801
116Abnormality of the gallbladder (HP:0005264)1.87612991
117Abnormal enzyme/coenzyme activity (HP:0012379)1.87351037
118Abnormality of vitamin metabolism (HP:0100508)1.86907140
119Broad alveolar ridges (HP:0000187)1.86065819
120Amyloidosis (HP:0011034)1.86005607
121Ependymoma (HP:0002888)1.85451071
122Menorrhagia (HP:0000132)1.84607835
123Pancreatic fibrosis (HP:0100732)1.83938998
124Thrombophlebitis (HP:0004418)1.83546812
125Elevated hepatic transaminases (HP:0002910)1.83292197
126Abnormality of the astrocytes (HP:0100707)1.82950378
127Astrocytoma (HP:0009592)1.82950378
128Pancreatic islet-cell hyperplasia (HP:0004510)1.82345056
129Reticulocytopenia (HP:0001896)1.81058895
130Myoglobinuria (HP:0002913)1.80264385
131Bifid tongue (HP:0010297)1.79513177
132Hemorrhage of the eye (HP:0011885)1.79429751
133Hypophosphatemic rickets (HP:0004912)1.78566952
134Rhabdomyosarcoma (HP:0002859)1.78223563
135Biliary tract neoplasm (HP:0100574)1.76375500
136Gastrointestinal atresia (HP:0002589)1.75686387
137Intestinal atresia (HP:0011100)1.75416714
138Hepatic necrosis (HP:0002605)1.74973562
139Abnormality of the septum pellucidum (HP:0007375)1.74369145
140Abnormality of glycolysis (HP:0004366)1.73082881
141Triphalangeal thumb (HP:0001199)1.72523034
142Partial duplication of thumb phalanx (HP:0009944)1.71590112
143Neoplasm of the colon (HP:0100273)1.69987380
144Pancreatic cysts (HP:0001737)1.69404729
145Neoplasm of the oral cavity (HP:0100649)1.69356372
146Volvulus (HP:0002580)1.67863296
147Neoplasm of the small intestine (HP:0100833)1.67364244
148Abnormality of the duodenum (HP:0002246)1.65532624
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.62865358
150Neoplasm of the adrenal cortex (HP:0100641)1.62856622
151True hermaphroditism (HP:0010459)1.62260923
152Hypoplastic pelvis (HP:0008839)1.59572916
153Scrotal hypoplasia (HP:0000046)1.59244026
154Birth length less than 3rd percentile (HP:0003561)1.58780930
155Absent forearm bone (HP:0003953)1.58254659
156Aplasia involving forearm bones (HP:0009822)1.58254659
157Choanal stenosis (HP:0000452)1.55882953
158Ectopic kidney (HP:0000086)1.55865228
159Bile duct proliferation (HP:0001408)1.55435739
160Abnormal biliary tract physiology (HP:0012439)1.55435739
161Absent radius (HP:0003974)1.55346292
162Acute necrotizing encephalopathy (HP:0006965)1.53840219
163Dandy-Walker malformation (HP:0001305)1.53573951
164Sclerocornea (HP:0000647)1.53048402
165Embryonal neoplasm (HP:0002898)1.52856399
166Myelomeningocele (HP:0002475)1.52679624
167Abnormal biliary tract morphology (HP:0012440)1.51915089
168Duplication of thumb phalanx (HP:0009942)1.51544336
169Humeroradial synostosis (HP:0003041)1.49963945
170Synostosis involving the elbow (HP:0003938)1.49963945
171Stenosis of the external auditory canal (HP:0000402)1.48197057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.96973937
2SIK14.03236076
3FGFR43.96489684
4ERN13.45409685
5CDC73.42005033
6CASK2.97086970
7INSRR2.87251106
8MKNK22.78233171
9TNIK2.67156849
10ERBB42.37705371
11TAOK32.34460817
12ZAK2.29382593
13PKN22.27008834
14MAP2K42.21358540
15MKNK12.19234832
16TTK2.12286216
17WEE12.08028878
18MST1R2.06737717
19SRPK12.02900253
20ACVR1B1.92087627
21TRIB31.91208070
22WNK41.89113496
23MAP4K21.85653010
24TSSK61.84980294
25BMPR1B1.82637825
26PNCK1.76220274
27BUB11.75699310
28PDK41.75224455
29PDK31.75224455
30PIK3CG1.71846208
31FLT31.71623957
32PLK31.70237877
33MAPK111.65190391
34WNK31.64379891
35NUAK11.61283089
36STK38L1.60788940
37PLK41.59167029
38BRSK21.57040237
39DYRK21.50507531
40PINK11.50189359
41MAP3K71.43499561
42LATS11.41584029
43BCR1.39412351
44PRKAA21.36922899
45TAF11.36754023
46ABL21.34965101
47STK241.34634993
48OXSR11.34544324
49PTK61.33990607
50FRK1.33335169
51VRK21.32734837
52FGFR21.30645687
53MAP3K41.29577013
54PLK11.27349680
55TYK21.21059697
56DAPK21.20056209
57NEK91.19128015
58STK31.17667837
59PBK1.17171373
60FGFR11.13460218
61TIE11.09734197
62VRK11.09670566
63MARK11.06507105
64JAK21.04394073
65KDR1.01221671
66MAP2K30.98643733
67MAP3K30.97922285
68NEK20.96311966
69MAPK40.95734887
70ATR0.94449056
71TLK10.93089281
72CHEK20.91704248
73PDK20.91434927
74CSNK1G20.89789170
75STK160.88188705
76NME10.86514914
77CAMK1D0.85822685
78PRKCZ0.85816386
79BRSK10.85443045
80MAPK120.84890088
81PRKAA10.84747457
82SGK30.83112227
83GRK60.82417290
84CSNK1G30.81049775
85GSK3A0.79732668
86ATM0.79178526
87MAPK150.79069319
88PRKACG0.78976842
89ERBB20.78840448
90TGFBR10.78805857
91BRD40.77850299
92CSNK1E0.77330594
93EPHB10.76659366
94MAPK130.76304746
95SGK2230.75057356
96SGK4940.75057356
97SGK20.74717453
98CDK60.74696997
99CSNK1A1L0.72684511
100CDK80.72341576
101MAP2K70.72298832
102DYRK1B0.72240740
103DMPK0.70959885
104AURKB0.68119345
105MAP3K140.67678883
106TGFBR20.67219581
107CDK190.67197521
108JAK10.66657653
109PDPK10.64960440
110MAP2K60.64367401
111CAMK2G0.64337080
112PHKG10.63195896
113PHKG20.63195896
114TBK10.62929924
115MAP3K100.62753768
116MET0.62609204
117MYLK0.61756446
118RIPK10.60629504
119EIF2AK20.60625186
120IRAK30.60306320
121TRIM280.60076320
122CSNK1D0.58444885
123OBSCN0.56868695
124MAPK70.55547284
125DYRK30.54817214
126MAP3K110.53941616
127PRKDC0.53514090
128CHEK10.52918218
129NTRK20.52699106
130EPHB20.52583076
131PLK20.52179234
132LATS20.51214723
133CDK10.51031683
134PRKCE0.49979079
135PAK30.49248436
136NEK10.49215056
137STK390.48615648
138MST40.48559027
139PRKCQ0.48548875
140CDK30.47344190
141CDK40.46267135
142CSNK2A20.46190739
143CSK0.45220509
144PDK10.44421375
145CDK20.44240940
146EPHA30.44079826
147MAP2K10.43175396
148CDK70.43057407
149PIK3CA0.42688615
150NLK0.42583960
151EPHA40.42435543
152CSNK1A10.42318170
153FGFR30.42087733
154ERBB30.42002186
155CCNB10.41738943
156IGF1R0.41511841
157MAP3K50.40412118
158NTRK30.39902200
159CSNK2A10.37548616
160CAMK1G0.37079524
161CSNK1G10.36673654
162GRK10.36101650
163MAP3K60.35372769
164CAMK40.35222429
165GSK3B0.35038030
166PRKCG0.34674147
167ADRBK20.34343089
168PTK20.33068216
169STK380.32932472
170MTOR0.32889392
171RET0.32815460
172PRKCA0.29295102
173IRAK20.28614864
174IRAK10.27246586
175ICK0.27231898
176MAP3K130.26980349
177PRKACA0.26732053
178TAOK20.26587248

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.12350672
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28325918
3Nitrogen metabolism_Homo sapiens_hsa009103.27209955
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09647529
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.88399753
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.79817762
7Fatty acid degradation_Homo sapiens_hsa000712.79722632
8Arginine biosynthesis_Homo sapiens_hsa002202.76268109
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72293616
10Tryptophan metabolism_Homo sapiens_hsa003802.68849789
11Butanoate metabolism_Homo sapiens_hsa006502.50172755
12Propanoate metabolism_Homo sapiens_hsa006402.46444180
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43212876
14Complement and coagulation cascades_Homo sapiens_hsa046102.32390485
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28403088
16Peroxisome_Homo sapiens_hsa041462.22086722
17Fatty acid metabolism_Homo sapiens_hsa012122.15450868
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07577333
19PPAR signaling pathway_Homo sapiens_hsa033201.99379125
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95445997
21Mismatch repair_Homo sapiens_hsa034301.89801589
22beta-Alanine metabolism_Homo sapiens_hsa004101.86559970
23Chemical carcinogenesis_Homo sapiens_hsa052041.83732304
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83420967
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83372811
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.81777305
27Histidine metabolism_Homo sapiens_hsa003401.81096049
28Pyruvate metabolism_Homo sapiens_hsa006201.67317375
29Fatty acid elongation_Homo sapiens_hsa000621.66860242
30Retinol metabolism_Homo sapiens_hsa008301.63065123
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.60688793
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60222350
33Non-homologous end-joining_Homo sapiens_hsa034501.50495464
34Phenylalanine metabolism_Homo sapiens_hsa003601.49235284
35Homologous recombination_Homo sapiens_hsa034401.48696639
36Bile secretion_Homo sapiens_hsa049761.47328409
37DNA replication_Homo sapiens_hsa030301.47059378
38Caffeine metabolism_Homo sapiens_hsa002321.46794731
39Selenocompound metabolism_Homo sapiens_hsa004501.46610301
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43147603
41Sulfur metabolism_Homo sapiens_hsa009201.42114342
42Staphylococcus aureus infection_Homo sapiens_hsa051501.38881477
43Carbon metabolism_Homo sapiens_hsa012001.35099338
44* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32619961
45Tyrosine metabolism_Homo sapiens_hsa003501.32502658
46Starch and sucrose metabolism_Homo sapiens_hsa005001.29309328
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.21816326
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.20944381
49Biosynthesis of amino acids_Homo sapiens_hsa012301.19885392
50Fanconi anemia pathway_Homo sapiens_hsa034601.17919469
51Steroid biosynthesis_Homo sapiens_hsa001001.15515490
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15178426
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13317700
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12299276
55ABC transporters_Homo sapiens_hsa020101.11701364
56Folate biosynthesis_Homo sapiens_hsa007901.11418822
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05585567
58Fat digestion and absorption_Homo sapiens_hsa049751.04641721
59RNA polymerase_Homo sapiens_hsa030201.03087465
60Arginine and proline metabolism_Homo sapiens_hsa003300.98433369
61Protein export_Homo sapiens_hsa030600.94047636
62Vitamin digestion and absorption_Homo sapiens_hsa049770.92567109
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.91464529
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91460574
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91254476
66Lysine degradation_Homo sapiens_hsa003100.90824594
67Nucleotide excision repair_Homo sapiens_hsa034200.90509211
68Base excision repair_Homo sapiens_hsa034100.89818352
69Spliceosome_Homo sapiens_hsa030400.89584359
70RNA transport_Homo sapiens_hsa030130.87954057
71Basal cell carcinoma_Homo sapiens_hsa052170.87564953
72Basal transcription factors_Homo sapiens_hsa030220.87087642
73RNA degradation_Homo sapiens_hsa030180.84427272
74Ribosome_Homo sapiens_hsa030100.84150435
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83014211
76Sulfur relay system_Homo sapiens_hsa041220.82918605
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81942460
78Vitamin B6 metabolism_Homo sapiens_hsa007500.80045515
79Cell cycle_Homo sapiens_hsa041100.78476929
80Glutathione metabolism_Homo sapiens_hsa004800.76600457
81Glycerolipid metabolism_Homo sapiens_hsa005610.74995567
82Cardiac muscle contraction_Homo sapiens_hsa042600.74167394
83Nicotine addiction_Homo sapiens_hsa050330.72009241
84Huntingtons disease_Homo sapiens_hsa050160.67354339
85Fatty acid biosynthesis_Homo sapiens_hsa000610.65084726
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59474600
87One carbon pool by folate_Homo sapiens_hsa006700.59004749
88Hedgehog signaling pathway_Homo sapiens_hsa043400.58817743
89Hippo signaling pathway_Homo sapiens_hsa043900.54684226
90Pentose phosphate pathway_Homo sapiens_hsa000300.54284173
91mRNA surveillance pathway_Homo sapiens_hsa030150.51666889
92* Metabolic pathways_Homo sapiens_hsa011000.50592128
93Pyrimidine metabolism_Homo sapiens_hsa002400.49482905
94Proteasome_Homo sapiens_hsa030500.49094831
95Phototransduction_Homo sapiens_hsa047440.48015117
96Purine metabolism_Homo sapiens_hsa002300.47606343
97TGF-beta signaling pathway_Homo sapiens_hsa043500.44291508
98Wnt signaling pathway_Homo sapiens_hsa043100.43238434
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42519906
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30583796
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.28303531
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28273886
103Insulin resistance_Homo sapiens_hsa049310.26665674
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25565699
105Fructose and mannose metabolism_Homo sapiens_hsa000510.25427079
106Galactose metabolism_Homo sapiens_hsa000520.24257172
107Prion diseases_Homo sapiens_hsa050200.17548641
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17365367
109Glucagon signaling pathway_Homo sapiens_hsa049220.17149564
110Linoleic acid metabolism_Homo sapiens_hsa005910.15070645
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.12789297
112AMPK signaling pathway_Homo sapiens_hsa041520.06930234
113African trypanosomiasis_Homo sapiens_hsa05143-0.2414473
114Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2292244
115Hepatitis C_Homo sapiens_hsa05160-0.2175934
116Regulation of autophagy_Homo sapiens_hsa04140-0.2172229
117Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2086897
118Protein digestion and absorption_Homo sapiens_hsa04974-0.1998845
119Mineral absorption_Homo sapiens_hsa04978-0.1994471
120Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1721182
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1677692
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1616718
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1605827
124Renin-angiotensin system_Homo sapiens_hsa04614-0.1573742
125Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1467216
126Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1460300
127Alzheimers disease_Homo sapiens_hsa05010-0.1443901
128Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1082095
129Parkinsons disease_Homo sapiens_hsa05012-0.1012620
130Insulin signaling pathway_Homo sapiens_hsa04910-0.0728455
131Oxidative phosphorylation_Homo sapiens_hsa00190-0.0444298
132Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0386231

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