PANK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.59805246
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.59805246
3modulation by symbiont of host immune response (GO:0052553)6.59805246
4positive regulation by symbiont of host defense response (GO:0052509)6.59805246
5modulation by symbiont of host defense response (GO:0052031)6.59805246
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.59805246
7regulation of interferon-beta biosynthetic process (GO:0045357)5.81406954
8macrophage activation involved in immune response (GO:0002281)5.68844680
9mannose metabolic process (GO:0006013)4.86791890
10positive regulation of gamma-delta T cell activation (GO:0046645)4.81578765
11detection of molecule of bacterial origin (GO:0032490)4.55012868
12positive regulation of interferon-alpha production (GO:0032727)4.52679079
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.50316219
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.50316219
15nuclear pore complex assembly (GO:0051292)4.48153926
16regulation of interferon-alpha production (GO:0032647)4.41579971
17positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.38993665
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.30245419
19response to host immune response (GO:0052572)4.30245419
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28911314
21negative regulation of cell killing (GO:0031342)4.28911314
22microglial cell activation (GO:0001774)4.27754245
23regulation of gamma-delta T cell differentiation (GO:0045586)4.20960431
24positive regulation of interferon-beta production (GO:0032728)4.14259375
25peptidyl-lysine dimethylation (GO:0018027)4.06753805
26DNA unwinding involved in DNA replication (GO:0006268)4.05996217
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04387961
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.02946781
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.93023526
30response to host (GO:0075136)3.93023526
31response to host defenses (GO:0052200)3.93023526
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.89299769
33nuclear pore organization (GO:0006999)3.84835024
34negative regulation of interleukin-12 production (GO:0032695)3.80969048
35glucose 6-phosphate metabolic process (GO:0051156)3.80546478
36antigen processing and presentation of endogenous antigen (GO:0019883)3.80403372
37detection of external biotic stimulus (GO:0098581)3.78601521
38meiotic chromosome segregation (GO:0045132)3.76623539
39detection of other organism (GO:0098543)3.76476608
40response to peptidoglycan (GO:0032494)3.76197727
41negative regulation of erythrocyte differentiation (GO:0045647)3.76066177
42regulation of interferon-beta production (GO:0032648)3.72796514
43positive regulation of histone deacetylation (GO:0031065)3.71113600
44natural killer cell differentiation (GO:0001779)3.69921379
45GDP-mannose metabolic process (GO:0019673)3.68068948
46macrophage activation (GO:0042116)3.66091681
47regulation of gamma-delta T cell activation (GO:0046643)3.56206296
48myeloid cell activation involved in immune response (GO:0002275)3.44957327
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.44864864
503-UTR-mediated mRNA stabilization (GO:0070935)3.43542295
51cellular response to virus (GO:0098586)3.43487278
52Peyers patch development (GO:0048541)3.42720593
53mucosal-associated lymphoid tissue development (GO:0048537)3.42720593
54neutrophil activation involved in immune response (GO:0002283)3.42546117
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42248993
56positive regulation of protein import into nucleus, translocation (GO:0033160)3.40357301
57detection of bacterium (GO:0016045)3.40048857
58B cell receptor signaling pathway (GO:0050853)3.38095174
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.36853088
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.36853088
61positive regulation of mitotic sister chromatid separation (GO:1901970)3.36853088
62cellular extravasation (GO:0045123)3.36307617
63histone H3-K36 demethylation (GO:0070544)3.34386952
64regulation of histone H3-K9 methylation (GO:0051570)3.33382626
65mitotic chromosome condensation (GO:0007076)3.31777110
66mitotic sister chromatid cohesion (GO:0007064)3.31705816
67mRNA stabilization (GO:0048255)3.29109008
68RNA stabilization (GO:0043489)3.29109008
69dosage compensation (GO:0007549)3.26105955
70cytoplasmic mRNA processing body assembly (GO:0033962)3.25571120
71I-kappaB phosphorylation (GO:0007252)3.24071112
72NIK/NF-kappaB signaling (GO:0038061)3.23908182
73detection of biotic stimulus (GO:0009595)3.23089619
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.19146490
75regulation of RNA export from nucleus (GO:0046831)3.18843874
76positive regulation of B cell differentiation (GO:0045579)3.17201664
77leukocyte aggregation (GO:0070486)3.14535272
78antigen processing and presentation via MHC class Ib (GO:0002475)3.10558753
79glucocorticoid receptor signaling pathway (GO:0042921)3.09682001
80interferon-gamma production (GO:0032609)3.07071498
81response to type I interferon (GO:0034340)3.06172558
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05368400
83monoubiquitinated protein deubiquitination (GO:0035520)3.03894829
84purinergic nucleotide receptor signaling pathway (GO:0035590)3.03138378
85neutrophil mediated immunity (GO:0002446)3.02250284
86regulation of nucleobase-containing compound transport (GO:0032239)3.01033664
87cellular response to type I interferon (GO:0071357)3.00710479
88type I interferon signaling pathway (GO:0060337)3.00710479
89positive regulation of protein deacetylation (GO:0090312)3.00657300
90B cell proliferation (GO:0042100)3.00568883
91positive T cell selection (GO:0043368)2.96556739
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.95470276
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93865036
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93523209
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90215456
96regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89280731
97negative regulation of histone methylation (GO:0031061)2.88774139
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88158864
99germinal center formation (GO:0002467)2.87022327
100corticosteroid receptor signaling pathway (GO:0031958)2.84863310
101G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.83713020
102respiratory burst (GO:0045730)2.83468077
103pore complex assembly (GO:0046931)2.83407454
104maternal placenta development (GO:0001893)2.81661094
105negative regulation of lymphocyte mediated immunity (GO:0002707)2.80280900
106dicarboxylic acid biosynthetic process (GO:0043650)2.78298341
107regulation of interleukin-8 biosynthetic process (GO:0045414)2.77402063
108immunoglobulin mediated immune response (GO:0016064)2.76106963
109regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.74361484
110chromatin assembly (GO:0031497)2.71658476
111regulation of interferon-gamma biosynthetic process (GO:0045072)2.70032171
112granulocyte differentiation (GO:0030851)2.68596538
113positive regulation of lamellipodium assembly (GO:0010592)2.66549901
114DNA duplex unwinding (GO:0032508)2.66445162
115DNA geometric change (GO:0032392)2.66387379
116regulation of MHC class I biosynthetic process (GO:0045343)2.66292245
117megakaryocyte development (GO:0035855)2.65862863
118negative T cell selection (GO:0043383)2.65749313
119T cell homeostasis (GO:0043029)2.65555908
120leukocyte migration involved in inflammatory response (GO:0002523)2.65510018
121defense response to protozoan (GO:0042832)2.64500123
122regulation of B cell receptor signaling pathway (GO:0050855)2.63583661
123myeloid leukocyte mediated immunity (GO:0002444)2.62751444
124cellular response to ethanol (GO:0071361)2.62026031
125regulation of B cell differentiation (GO:0045577)2.61814410
126heterochromatin organization (GO:0070828)2.61085552
127negative thymic T cell selection (GO:0045060)2.60539540
128pre-miRNA processing (GO:0031054)2.60511409
129negative regulation of RNA splicing (GO:0033119)2.60302061
130regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60104250
131negative regulation of phagocytosis (GO:0050765)2.59642909
132response to epidermal growth factor (GO:0070849)2.58964598
133negative regulation of B cell proliferation (GO:0030889)2.58614835
134histone phosphorylation (GO:0016572)2.58448372
135positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57558037
136lipopolysaccharide-mediated signaling pathway (GO:0031663)2.57338052
137T cell migration (GO:0072678)2.55550835
138negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55297918
139regulation of erythrocyte differentiation (GO:0045646)2.54739266
140regulation of protein polyubiquitination (GO:1902914)2.53673115
141purinergic receptor signaling pathway (GO:0035587)2.52626932
142regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.52320001
143tolerance induction (GO:0002507)2.50036440
144response to protozoan (GO:0001562)2.50031606
145regulation of sister chromatid cohesion (GO:0007063)2.49444163
146regulation of mast cell degranulation (GO:0043304)2.48669663
147mitotic G1 DNA damage checkpoint (GO:0031571)2.47651295
148production of molecular mediator involved in inflammatory response (GO:0002532)2.46860150
149T cell selection (GO:0045058)2.46344632
150regulation of antigen processing and presentation (GO:0002577)2.46233757
151necroptotic process (GO:0070266)2.46055685
152histone mRNA catabolic process (GO:0071044)2.45771273
153response to muramyl dipeptide (GO:0032495)2.45630890
154regulation of protein import into nucleus, translocation (GO:0033158)2.45460111
155B cell mediated immunity (GO:0019724)2.44188525
156necrotic cell death (GO:0070265)2.43876147
157adenosine receptor signaling pathway (GO:0001973)2.43635430
158regulation of mRNA stability (GO:0043488)2.43313299
159positive thymic T cell selection (GO:0045059)2.43019393
160programmed necrotic cell death (GO:0097300)2.42371610
161negative regulation of type I interferon production (GO:0032480)2.41023327
162positive regulation of chromosome segregation (GO:0051984)2.40937168
163regulation of interleukin-6 biosynthetic process (GO:0045408)2.40439019
164regulation of necroptotic process (GO:0060544)2.37570691
165negative regulation of T cell mediated immunity (GO:0002710)2.37491167
166histone H3-K9 modification (GO:0061647)2.37212521
167negative regulation of granulocyte differentiation (GO:0030853)2.37048290
168gene silencing by RNA (GO:0031047)2.36602266
169positive regulation of lamellipodium organization (GO:1902745)2.36434644
170definitive hemopoiesis (GO:0060216)2.36429031
171regulation of natural killer cell mediated immunity (GO:0002715)2.35268034
172regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.35268034
173mature B cell differentiation (GO:0002335)2.35163603
174ncRNA 3-end processing (GO:0043628)2.33586122
175histone H3-K9 methylation (GO:0051567)2.32351001
176histone H3-K4 trimethylation (GO:0080182)2.31905251
177regulation of fatty acid beta-oxidation (GO:0031998)2.31267225
178regulation of RNA stability (GO:0043487)2.30862305
179cellular hyperosmotic response (GO:0071474)2.30351909
180chromosome condensation (GO:0030261)2.29807809
181positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.28553697
182response to interleukin-15 (GO:0070672)2.27981135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.90210392
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.86688147
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.88246053
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.75849081
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56221007
6MYC_22102868_ChIP-Seq_BL_Human3.45729020
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.29320999
8SCL_19346495_ChIP-Seq_HPC-7_Human2.79521855
9* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77813886
10VDR_21846776_ChIP-Seq_THP-1_Human2.69204451
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60577573
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51260526
13TCF7_22412390_ChIP-Seq_EML_Mouse2.49000182
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47641942
15MAF_26560356_Chip-Seq_TH1_Human2.26808629
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.25020417
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.22967499
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09099420
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07774776
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.04321487
21MYB_26560356_Chip-Seq_TH2_Human2.01920352
22KDM2B_26808549_Chip-Seq_DND41_Human2.00625796
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98790420
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97644005
25UTX_26944678_Chip-Seq_JUKART_Human1.95873599
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.95355455
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93039578
28ZNF263_19887448_ChIP-Seq_K562_Human1.92283754
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91544767
30MYB_26560356_Chip-Seq_TH1_Human1.91446140
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.90330356
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90182926
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.89619571
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87605213
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80583905
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78458049
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.76860583
38VDR_24763502_ChIP-Seq_THP-1_Human1.75941681
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74116663
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.71781373
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70564573
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.70548555
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69643713
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66106022
45CIITA_25753668_ChIP-Seq_RAJI_Human1.65976725
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65898546
47RUNX_20019798_ChIP-Seq_JUKART_Human1.65835691
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65685097
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65103655
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58213976
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52630550
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52044889
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50795739
54MAF_26560356_Chip-Seq_TH2_Human1.45644539
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44212163
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42443342
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40951813
58* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40031022
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39510395
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39357717
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38671888
62SPI1_23127762_ChIP-Seq_K562_Human1.35200460
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.34055741
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32436142
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.30204356
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29936528
67VDR_23849224_ChIP-Seq_CD4+_Human1.28544032
68TFEB_21752829_ChIP-Seq_HELA_Human1.28443896
69XRN2_22483619_ChIP-Seq_HELA_Human1.25316567
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24608626
71AR_21909140_ChIP-Seq_LNCAP_Human1.23258222
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23083885
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20942860
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20214511
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19791517
76* SPI1_23547873_ChIP-Seq_NB4_Human1.19068459
77GATA3_27048872_Chip-Seq_THYMUS_Human1.18931230
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18474048
79FOXP3_21729870_ChIP-Seq_TREG_Human1.18130932
80NCOR1_26117541_ChIP-Seq_K562_Human1.17686483
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16666213
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16042489
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.13966083
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13703549
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13347595
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11825934
87* GABP_19822575_ChIP-Seq_HepG2_Human1.11510556
88RXR_22158963_ChIP-Seq_LIVER_Mouse1.11059366
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.09543066
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.09422789
91PU_27001747_Chip-Seq_BMDM_Mouse1.07919639
92KDM5A_27292631_Chip-Seq_BREAST_Human1.07794982
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07537516
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07496799
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05722479
96TP53_22127205_ChIP-Seq_IMR90_Human1.05380789
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05052261
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04568867
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04384935
100* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03423351
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01576679
102BCOR_27268052_Chip-Seq_Bcells_Human1.01405557
103NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01197585
104* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00489527
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00383704
106MYC_18555785_ChIP-Seq_MESCs_Mouse1.00289648
107GATA3_26560356_Chip-Seq_TH2_Human0.99468433
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99152437
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98157892
110CLOCK_20551151_ChIP-Seq_293T_Human0.98066347
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97812165
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97204587
113* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96699045
114* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96434350
115* DCP1A_22483619_ChIP-Seq_HELA_Human0.96235906
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95533135
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94686144
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94627995
119CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93529419
120* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91784368
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90737300
122GATA1_19941826_ChIP-Seq_K562_Human0.90462760
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89311920
124GATA6_25053715_ChIP-Seq_YYC3_Human0.88622657
125GATA1_22025678_ChIP-Seq_K562_Human0.88341540
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87469645
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86120206
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84713655
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83532256
130KDM2B_26808549_Chip-Seq_K562_Human0.83513053
131* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82694670
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81455380
133* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80944927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.41834481
2MP0010352_gastrointestinal_tract_polyps3.18656937
3MP0002396_abnormal_hematopoietic_system2.93803454
4MP0003303_peritoneal_inflammation2.90029587
5MP0008260_abnormal_autophagy2.89961820
6MP0000685_abnormal_immune_system2.53050433
7MP0003705_abnormal_hypodermis_morpholog2.51560989
8MP0001545_abnormal_hematopoietic_system2.26881790
9MP0005397_hematopoietic_system_phenotyp2.26881790
10MP0004808_abnormal_hematopoietic_stem2.25259086
11MP0000569_abnormal_digit_pigmentation2.23819381
12MP0005076_abnormal_cell_differentiation2.18419356
13MP0005671_abnormal_response_to2.17207996
14MP0001835_abnormal_antigen_presentation2.10023862
15MP0002398_abnormal_bone_marrow2.02563243
16MP0000015_abnormal_ear_pigmentation2.00490246
17MP0001800_abnormal_humoral_immune1.92067412
18MP0004510_myositis1.83525217
19MP0005360_urolithiasis1.79549968
20MP0001915_intracranial_hemorrhage1.79475200
21MP0003172_abnormal_lysosome_physiology1.79198336
22MP0005451_abnormal_body_composition1.78953508
23MP0010155_abnormal_intestine_physiology1.73375889
24MP0005464_abnormal_platelet_physiology1.72653097
25MP0003436_decreased_susceptibility_to1.68667033
26MP0009278_abnormal_bone_marrow1.68152467
27MP0003763_abnormal_thymus_physiology1.67468157
28MP0004185_abnormal_adipocyte_glucose1.66138471
29MP0002148_abnormal_hypersensitivity_rea1.65929351
30MP0000689_abnormal_spleen_morphology1.65329425
31MP0003656_abnormal_erythrocyte_physiolo1.65149198
32MP0010094_abnormal_chromosome_stability1.65132411
33MP0004957_abnormal_blastocyst_morpholog1.64859364
34MP0000703_abnormal_thymus_morphology1.64278042
35MP0003566_abnormal_cell_adhesion1.61644080
36MP0002452_abnormal_antigen_presenting1.60180404
37MP0003693_abnormal_embryo_hatching1.59644156
38MP0000490_abnormal_crypts_of1.59423163
39MP0002166_altered_tumor_susceptibility1.57731327
40MP0003111_abnormal_nucleus_morphology1.56927660
41MP0002420_abnormal_adaptive_immunity1.55635187
42MP0002877_abnormal_melanocyte_morpholog1.55594659
43MP0001293_anophthalmia1.55577150
44MP0010307_abnormal_tumor_latency1.55398128
45MP0001819_abnormal_immune_cell1.54887984
46MP0004264_abnormal_extraembryonic_tissu1.52094232
47MP0003252_abnormal_bile_duct1.51425404
48MP0002722_abnormal_immune_system1.50077837
49MP0009764_decreased_sensitivity_to1.49558406
50MP0000716_abnormal_immune_system1.46960258
51MP0005083_abnormal_biliary_tract1.46537120
52MP0002723_abnormal_immune_serum1.46241577
53MP0004130_abnormal_muscle_cell1.46234003
54MP0005310_abnormal_salivary_gland1.46047334
55MP0000465_gastrointestinal_hemorrhage1.42877553
56MP0010234_abnormal_vibrissa_follicle1.42574322
57MP0009333_abnormal_splenocyte_physiolog1.40728831
58MP0005000_abnormal_immune_tolerance1.39184460
59MP0001790_abnormal_immune_system1.38832099
60MP0005387_immune_system_phenotype1.38832099
61MP0003077_abnormal_cell_cycle1.37960662
62MP0005025_abnormal_response_to1.37380304
63MP0002429_abnormal_blood_cell1.34905322
64MP0001986_abnormal_taste_sensitivity1.31493351
65MP0005167_abnormal_blood-brain_barrier1.28655990
66MP0000350_abnormal_cell_proliferation1.27664628
67MP0000858_altered_metastatic_potential1.26820206
68MP0002019_abnormal_tumor_incidence1.24342074
69MP0000609_abnormal_liver_physiology1.23372926
70MP0002419_abnormal_innate_immunity1.21180810
71MP0002086_abnormal_extraembryonic_tissu1.20615073
72MP0010329_abnormal_lipoprotein_level1.19064215
73MP0002132_abnormal_respiratory_system1.18148405
74MP0003828_pulmonary_edema1.18059546
75MP0002277_abnormal_respiratory_mucosa1.17226697
76MP0001533_abnormal_skeleton_physiology1.16519004
77MP0002139_abnormal_hepatobiliary_system1.16469116
78MP0002006_tumorigenesis1.16273500
79MP0001348_abnormal_lacrimal_gland1.15834586
80MP0003453_abnormal_keratinocyte_physiol1.15303620
81MP0003221_abnormal_cardiomyocyte_apopto1.13300779
82MP0002405_respiratory_system_inflammati1.13205784
83MP0002254_reproductive_system_inflammat1.13126373
84MP0005365_abnormal_bile_salt1.10477580
85MP0008469_abnormal_protein_level1.10235520
86MP0009785_altered_susceptibility_to1.06597666
87MP0008877_abnormal_DNA_methylation1.05397877
88MP0004947_skin_inflammation1.05366636
89MP0001845_abnormal_inflammatory_respons1.05113318
90MP0005666_abnormal_adipose_tissue1.03979836
91MP0001873_stomach_inflammation1.03891495
92MP0009840_abnormal_foam_cell1.02650724
93MP0005174_abnormal_tail_pigmentation0.97294361
94MP0003091_abnormal_cell_migration0.96788189
95MP0005621_abnormal_cell_physiology0.96518036
96MP0008057_abnormal_DNA_replication0.96471795
97MP0005023_abnormal_wound_healing0.96049366
98MP0001730_embryonic_growth_arrest0.94851001
99MP0001697_abnormal_embryo_size0.93936708
100MP0000477_abnormal_intestine_morphology0.93450588
101MP0002138_abnormal_hepatobiliary_system0.93023328
102MP0005085_abnormal_gallbladder_physiolo0.92860130
103MP0006054_spinal_hemorrhage0.92675346
104MP0002089_abnormal_postnatal_growth/wei0.92119892
105MP0001663_abnormal_digestive_system0.91432928
106MP0008007_abnormal_cellular_replicative0.91139569
107MP0000313_abnormal_cell_death0.90860110
108MP0001879_abnormal_lymphatic_vessel0.90592579
109MP0003448_altered_tumor_morphology0.90042531
110MP0004883_abnormal_blood_vessel0.89519564
111MP0000598_abnormal_liver_morphology0.89155643
112MP0006082_CNS_inflammation0.88913067
113MP0003890_abnormal_embryonic-extraembry0.88730306
114MP0006035_abnormal_mitochondrial_morpho0.88728111
115MP0003984_embryonic_growth_retardation0.88617340
116MP0000733_abnormal_muscle_development0.88574022
117MP0002088_abnormal_embryonic_growth/wei0.88391449
118MP0004197_abnormal_fetal_growth/weight/0.87988899
119MP0003183_abnormal_peptide_metabolism0.86524645
120MP0003724_increased_susceptibility_to0.85496795
121MP0002092_abnormal_eye_morphology0.83741157
122MP0002080_prenatal_lethality0.83578569
123MP0001672_abnormal_embryogenesis/_devel0.83454532
124MP0005380_embryogenesis_phenotype0.83454532
125MP0001853_heart_inflammation0.83161883
126MP0003123_paternal_imprinting0.82924156
127MP0005058_abnormal_lysosome_morphology0.81808836
128MP0004381_abnormal_hair_follicle0.80477286
129MP0003806_abnormal_nucleotide_metabolis0.79007805
130MP0005164_abnormal_response_to0.78793095
131MP0004043_abnormal_pH_regulation0.77411589
132MP0005384_cellular_phenotype0.75884827
133MP0009765_abnormal_xenobiotic_induced0.74582203
134MP0009763_increased_sensitivity_to0.74374886
135MP0008058_abnormal_DNA_repair0.72401379
136MP0000371_diluted_coat_color0.70488667
137MP0005171_absent_coat_pigmentation0.66266649
138MP0000358_abnormal_cell_content/0.65306226
139MP0003646_muscle_fatigue0.64796671

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.72858848
2Recurrent abscess formation (HP:0002722)4.26352885
3Abnormality of macrophages (HP:0004311)3.86690841
4Orchitis (HP:0100796)3.85814333
5Recurrent gram-negative bacterial infections (HP:0005420)3.59590224
6Chronic mucocutaneous candidiasis (HP:0002728)3.57174326
7Recurrent cutaneous fungal infections (HP:0011370)3.57174326
8Retrobulbar optic neuritis (HP:0100654)3.56234153
9Optic neuritis (HP:0100653)3.56234153
10Abnormal gallbladder physiology (HP:0012438)3.55647873
11Cholecystitis (HP:0001082)3.55647873
12Birth length less than 3rd percentile (HP:0003561)3.45891124
13Absent eyelashes (HP:0000561)3.44537926
14Recurrent skin infections (HP:0001581)3.38506184
15Absent eyebrow (HP:0002223)3.36892475
16Dyschromatopsia (HP:0007641)3.14561946
17Abnormality of the fingertips (HP:0001211)3.08701627
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.01415039
19Deep palmar crease (HP:0006191)2.92243263
20Meningitis (HP:0001287)2.85266346
21Hypoplasia of the pons (HP:0012110)2.78228953
22Thrombocytosis (HP:0001894)2.77535731
23Gastrointestinal infarctions (HP:0005244)2.77527429
24Breast hypoplasia (HP:0003187)2.76134616
25Agammaglobulinemia (HP:0004432)2.74478061
26Abnormality of the pons (HP:0007361)2.73207918
27Obstructive lung disease (HP:0006536)2.60776878
28Chronic obstructive pulmonary disease (HP:0006510)2.60776878
29Abnormality of the nasal mucosa (HP:0000433)2.60076581
30Encephalitis (HP:0002383)2.58770098
31Midline defect of the nose (HP:0004122)2.57909990
32Nasal polyposis (HP:0100582)2.56557083
33Recurrent viral infections (HP:0004429)2.53523252
34Intestinal fistula (HP:0100819)2.52430712
35Skull defect (HP:0001362)2.49990533
36Stomatitis (HP:0010280)2.48885325
37Persistence of primary teeth (HP:0006335)2.47003146
38Recurrent bronchitis (HP:0002837)2.45598148
39Squamous cell carcinoma (HP:0002860)2.45014252
40Mediastinal lymphadenopathy (HP:0100721)2.44489600
41Gingivitis (HP:0000230)2.44161304
42Progressive external ophthalmoplegia (HP:0000590)2.41115326
43Keratoconjunctivitis sicca (HP:0001097)2.40937955
44Reticulocytosis (HP:0001923)2.39566094
45IgM deficiency (HP:0002850)2.38857008
46Rectal fistula (HP:0100590)2.38251483
47Rectovaginal fistula (HP:0000143)2.38251483
48Anorexia (HP:0002039)2.38110209
49Keratoconjunctivitis (HP:0001096)2.36912450
50Recurrent pneumonia (HP:0006532)2.35145305
51Abnormal platelet volume (HP:0011876)2.34878734
52Hypochromic anemia (HP:0001931)2.34839952
53Vasculitis (HP:0002633)2.30579654
54Hematochezia (HP:0002573)2.29725172
55Hyperacusis (HP:0010780)2.28182794
56Spontaneous hematomas (HP:0007420)2.23393473
57Osteomyelitis (HP:0002754)2.21705064
58Petechiae (HP:0000967)2.21658097
59Interstitial pulmonary disease (HP:0006530)2.21464785
60Abnormality of the common coagulation pathway (HP:0010990)2.20053802
61Slow saccadic eye movements (HP:0000514)2.19680914
62Prolonged bleeding time (HP:0003010)2.19440241
63Abnormality of reticulocytes (HP:0004312)2.18954516
64Hemorrhage of the eye (HP:0011885)2.17946833
65Leukocytosis (HP:0001974)2.12701578
66Increased mean platelet volume (HP:0011877)2.12677600
67Rib fusion (HP:0000902)2.12665865
68Basal cell carcinoma (HP:0002671)2.12361460
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12130296
70Short 4th metacarpal (HP:0010044)2.12130296
71Acute myeloid leukemia (HP:0004808)2.09935921
72Cellulitis (HP:0100658)2.09608408
73IgA deficiency (HP:0002720)2.09054557
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08536361
75Vaginal fistula (HP:0004320)2.08455335
76Chronic otitis media (HP:0000389)2.07640374
77Poikiloderma (HP:0001029)2.06294757
78Cutis marmorata (HP:0000965)2.06150181
79T lymphocytopenia (HP:0005403)2.05852624
80Panhypogammaglobulinemia (HP:0003139)2.05055319
81Aplasia/Hypoplasia of the sternum (HP:0006714)2.04512422
82Chromsome breakage (HP:0040012)2.04123109
83Myelodysplasia (HP:0002863)2.04013435
84Truncal obesity (HP:0001956)2.03903067
85Joint hemorrhage (HP:0005261)2.03658073
86Increased density of long bones (HP:0006392)2.02928232
87Morphological abnormality of the middle ear (HP:0008609)2.02539053
88Lymphopenia (HP:0001888)2.01173276
89Wide nose (HP:0000445)2.00502309
90Gingival bleeding (HP:0000225)1.99889812
91Recurrent fungal infections (HP:0002841)1.99535176
92Spastic diplegia (HP:0001264)1.99053649
93Abnormality of chromosome stability (HP:0003220)1.98325053
94Prolonged partial thromboplastin time (HP:0003645)1.98066500
95Thyroiditis (HP:0100646)1.98065685
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97286351
97Bilateral microphthalmos (HP:0007633)1.96203868
98Visual hallucinations (HP:0002367)1.95163869
99Recurrent lower respiratory tract infections (HP:0002783)1.94982292
100Increased serum ferritin (HP:0003281)1.93825557
101Hypochromic microcytic anemia (HP:0004840)1.92706724
102Viral hepatitis (HP:0006562)1.92390014
103Hypoplasia of the thymus (HP:0000778)1.92081092
104Dysmetric saccades (HP:0000641)1.91645766
105Abnormality of T cell number (HP:0011839)1.91319676
106Purpura (HP:0000979)1.91282742
107Pustule (HP:0200039)1.91114235
108Abnormality of iron homeostasis (HP:0011031)1.90804609
109Heterotopia (HP:0002282)1.89700642
110Gastrointestinal stroma tumor (HP:0100723)1.89650362
111Subacute progressive viral hepatitis (HP:0006572)1.89383316
112Testicular atrophy (HP:0000029)1.88575320
113Arterial thrombosis (HP:0004420)1.87434356
114Leukopenia (HP:0001882)1.86656046
115Gastrointestinal inflammation (HP:0004386)1.86379416
116Achilles tendon contracture (HP:0001771)1.86154539
117Abnormality of the Achilles tendon (HP:0005109)1.86103060
118Myositis (HP:0100614)1.85828067
119Submucous cleft hard palate (HP:0000176)1.85622082
120Periodontitis (HP:0000704)1.85433902
121Urticaria (HP:0001025)1.85296432
122Abnormality of cells of the lymphoid lineage (HP:0012140)1.84450165
123Abnormality of the thymus (HP:0000777)1.83791385
124B lymphocytopenia (HP:0010976)1.83702297
125Abnormality of B cell number (HP:0010975)1.83702297
126Hypoalbuminemia (HP:0003073)1.83598157
127Abnormal albumin level (HP:0012116)1.83598157
128Broad palm (HP:0001169)1.82615722
129Reticulocytopenia (HP:0001896)1.82311713
130Entropion (HP:0000621)1.82166006
131Biliary tract neoplasm (HP:0100574)1.82083525
132Papilloma (HP:0012740)1.81822175
133Verrucae (HP:0200043)1.81822175
134Peritonitis (HP:0002586)1.80766155
135Volvulus (HP:0002580)1.80556960
136Lymphoma (HP:0002665)1.80307809
137Colitis (HP:0002583)1.80234054
138Facial diplegia (HP:0001349)1.80224485
139Facial hemangioma (HP:0000329)1.80010139
140Choroideremia (HP:0001139)1.79515986
141Tracheal stenosis (HP:0002777)1.79515219
142Acute lymphatic leukemia (HP:0006721)1.79463598
143Eczematoid dermatitis (HP:0000976)1.78334721
144Aneurysm (HP:0002617)1.78314417
145Pelvic girdle muscle weakness (HP:0003749)1.78110520
146Autoimmune thrombocytopenia (HP:0001973)1.77380124
147Cholelithiasis (HP:0001081)1.77220414
148Hyperbilirubinemia (HP:0002904)1.76727961
149Sandal gap (HP:0001852)1.76602651
150Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.76464903
151Short 1st metacarpal (HP:0010034)1.76464903
152Macroorchidism (HP:0000053)1.76146269
153Epistaxis (HP:0000421)1.75998699
154Mitral valve prolapse (HP:0001634)1.75307229
155Abnormality of DNA repair (HP:0003254)1.75070745
156Genu recurvatum (HP:0002816)1.74941372
157Abnormality of the pubic bones (HP:0003172)1.74915314
158Reduced subcutaneous adipose tissue (HP:0003758)1.74565020
159Abnormality of T cells (HP:0002843)1.73436607
160Annular pancreas (HP:0001734)1.72865866
161Pointed chin (HP:0000307)1.72684248
162Elevated erythrocyte sedimentation rate (HP:0003565)1.72479430
163Abnormal delayed hypersensitivity skin test (HP:0002963)1.70686262
164Apathy (HP:0000741)1.70643543
165Diminished motivation (HP:0000745)1.70494389
166Prominent nose (HP:0000448)1.70168464
167Inflammation of the large intestine (HP:0002037)1.69945413
168Myocardial infarction (HP:0001658)1.69055784
169Ependymoma (HP:0002888)1.67868436
170Thin bony cortex (HP:0002753)1.67294762
171Recurrent sinusitis (HP:0011108)1.65522639
172Polygenic inheritance (HP:0010982)1.65097860
173Renovascular hypertension (HP:0100817)1.61592753
174Cerebral aneurysm (HP:0004944)1.61568044
175Chest pain (HP:0100749)1.61528130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.07195621
2TRIB34.00772429
3PKN23.25896738
4IRAK42.89570099
5BLK2.82607028
6TLK12.61680846
7MAP3K102.49001681
8SIK22.48764605
9EEF2K2.47144255
10CDK122.15480742
11JAK32.07805528
12FGR1.96428499
13ACVR1B1.93595259
14AKT31.91597050
15MAP4K11.90446693
16NEK21.79415530
17STK101.77510027
18ZAK1.68462237
19CDC71.66626438
20IKBKE1.63315693
21CDK61.62978460
22BRD41.60263403
23FLT31.59741266
24TGFBR11.53928245
25KSR21.53752106
26SIK11.53436155
27BRSK21.48106666
28PRPF4B1.47115065
29MAP3K141.45022413
30PTK61.44520783
31MAP3K111.41611072
32MAP3K61.38993682
33CDK41.34574231
34BMPR1B1.32083783
35TAOK11.29134267
36LRRK21.27589543
37FES1.24075342
38GRK61.23753159
39ZAP701.22426226
40TGFBR21.21287418
41JAK21.17216932
42TBK11.16587173
43BMX1.15899322
44KIT1.14375232
45RET1.12947875
46SIK31.12880652
47MAP3K51.12637809
48RIPK11.12475466
49MELK1.11156504
50TYK21.09714236
51PDGFRA1.06898389
52CSF1R1.05979390
53ERN11.05780964
54PTK2B1.03559730
55RAF11.02702464
56BRAF1.01048970
57RPS6KA41.00658798
58TEC0.99816544
59MAP2K30.99669167
60WNK10.98626985
61PDK10.97375468
62SGK30.97344406
63MAP3K30.97064112
64JAK10.96567648
65SCYL20.95378525
66FGFR30.94660737
67STK110.88996238
68ALK0.88637835
69TTN0.85837535
70MAP2K60.85046874
71YES10.84928240
72MAP3K80.84903465
73SRPK10.83917292
74CAMKK10.81902009
75PIM20.80971155
76FRK0.80224966
77IKBKB0.79144332
78TAOK20.77986345
79SGK20.77778260
80SYK0.77463890
81PDGFRB0.77424976
82BTK0.77248868
83PRKD20.76833221
84MAP3K70.76631934
85HCK0.76212695
86CAMKK20.76165532
87CAMK1D0.76140697
88MATK0.75531893
89STK30.74052369
90CAMK1G0.73496909
91MAP3K130.73333686
92PDPK10.72693834
93PIM10.72119892
94MST40.72027543
95MARK20.70967503
96IRAK20.69879288
97RPS6KB20.69108481
98ADRBK10.68670318
99DMPK0.67841020
100FGFR40.67790667
101MARK30.67329836
102IRAK30.67008338
103MKNK20.67006028
104AKT20.66840343
105PRKCH0.66427514
106MAPK110.66257534
107MAP2K40.64193268
108LCK0.63798581
109DYRK30.63261060
110KSR10.63228436
111CDK70.63148652
112MAP3K20.62504694
113TESK20.58189236
114EPHA40.56680512
115CDK90.56222682
116STK380.53532991
117DDR20.53016186
118ATR0.51779643
119NLK0.50703725
120NME20.49720427
121STK240.49358555
122DYRK1B0.49021508
123MAP4K20.47814301
124TESK10.47039135
125ITK0.46199013
126CDK190.45905397
127TYRO30.44620451
128TNK20.44601420
129STK40.42357365
130CDC42BPA0.39916900
131LYN0.39910745
132IRAK10.39635696
133MAP3K10.39374835
134AURKB0.39367216
135CHEK20.38607862
136NEK90.38394387
137CSK0.38127710
138EGFR0.37243636
139WEE10.35891894
140TTK0.35566199
141AKT10.34471258
142MAP2K10.34171420
143MTOR0.33018379
144CHEK10.32603310
145EPHA30.32101342

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.57987285
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68293373
3Nitrogen metabolism_Homo sapiens_hsa009102.59745813
4B cell receptor signaling pathway_Homo sapiens_hsa046622.14056977
5NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93068010
6DNA replication_Homo sapiens_hsa030301.82623352
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81190829
8Acute myeloid leukemia_Homo sapiens_hsa052211.76463354
9Non-small cell lung cancer_Homo sapiens_hsa052231.71516499
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64544572
11Chronic myeloid leukemia_Homo sapiens_hsa052201.61565843
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53031690
13Allograft rejection_Homo sapiens_hsa053301.52428110
14Other glycan degradation_Homo sapiens_hsa005111.46172797
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46017568
16Glioma_Homo sapiens_hsa052141.39181052
17Osteoclast differentiation_Homo sapiens_hsa043801.37185815
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37029567
19Graft-versus-host disease_Homo sapiens_hsa053321.36969111
20Thyroid cancer_Homo sapiens_hsa052161.36872737
21Homologous recombination_Homo sapiens_hsa034401.33702496
22Leishmaniasis_Homo sapiens_hsa051401.33436422
23Malaria_Homo sapiens_hsa051441.32090319
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.31267647
25Primary immunodeficiency_Homo sapiens_hsa053401.30215960
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29915749
27mTOR signaling pathway_Homo sapiens_hsa041501.28353950
28Pancreatic cancer_Homo sapiens_hsa052121.27766271
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26367478
30Autoimmune thyroid disease_Homo sapiens_hsa053201.25198725
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23824076
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23177941
33Lysine degradation_Homo sapiens_hsa003101.20375095
34Hepatitis B_Homo sapiens_hsa051611.19952221
35Epstein-Barr virus infection_Homo sapiens_hsa051691.19015709
36Non-homologous end-joining_Homo sapiens_hsa034501.18514379
37VEGF signaling pathway_Homo sapiens_hsa043701.18353774
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17448057
39Endometrial cancer_Homo sapiens_hsa052131.16509401
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.16020615
41Colorectal cancer_Homo sapiens_hsa052101.15852989
42Bladder cancer_Homo sapiens_hsa052191.15157154
43Type II diabetes mellitus_Homo sapiens_hsa049301.14288582
44T cell receptor signaling pathway_Homo sapiens_hsa046601.13846568
45Systemic lupus erythematosus_Homo sapiens_hsa053221.10462236
46Fanconi anemia pathway_Homo sapiens_hsa034601.09609135
47Insulin resistance_Homo sapiens_hsa049311.04235649
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03521006
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01684285
50Measles_Homo sapiens_hsa051621.01527093
51Viral carcinogenesis_Homo sapiens_hsa052030.99353389
52Long-term potentiation_Homo sapiens_hsa047200.98154489
53Small cell lung cancer_Homo sapiens_hsa052220.97702487
54Caffeine metabolism_Homo sapiens_hsa002320.96242741
55Platelet activation_Homo sapiens_hsa046110.95984437
56HTLV-I infection_Homo sapiens_hsa051660.95845414
57Toxoplasmosis_Homo sapiens_hsa051450.95364473
58Prolactin signaling pathway_Homo sapiens_hsa049170.94718354
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93416270
60Herpes simplex infection_Homo sapiens_hsa051680.93341334
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.92009458
62Mismatch repair_Homo sapiens_hsa034300.91155528
63Staphylococcus aureus infection_Homo sapiens_hsa051500.89670824
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89262074
65TNF signaling pathway_Homo sapiens_hsa046680.87220826
66Lysosome_Homo sapiens_hsa041420.87068223
67Insulin signaling pathway_Homo sapiens_hsa049100.87044999
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86824067
69Arginine biosynthesis_Homo sapiens_hsa002200.86799713
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86120198
71Shigellosis_Homo sapiens_hsa051310.85186017
72Apoptosis_Homo sapiens_hsa042100.83806728
73Cell cycle_Homo sapiens_hsa041100.83742652
74African trypanosomiasis_Homo sapiens_hsa051430.83543900
75Influenza A_Homo sapiens_hsa051640.83473709
76Asthma_Homo sapiens_hsa053100.82400309
77Proteoglycans in cancer_Homo sapiens_hsa052050.81213270
78MicroRNAs in cancer_Homo sapiens_hsa052060.80319601
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80100310
80Prostate cancer_Homo sapiens_hsa052150.79356663
81HIF-1 signaling pathway_Homo sapiens_hsa040660.76571924
82Inositol phosphate metabolism_Homo sapiens_hsa005620.75762031
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.75671032
84Sphingolipid metabolism_Homo sapiens_hsa006000.75361256
85Estrogen signaling pathway_Homo sapiens_hsa049150.75331528
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74413121
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73813359
88Base excision repair_Homo sapiens_hsa034100.72255364
89Chemokine signaling pathway_Homo sapiens_hsa040620.72113003
90One carbon pool by folate_Homo sapiens_hsa006700.71899887
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71722812
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.70679107
93Dorso-ventral axis formation_Homo sapiens_hsa043200.70615017
94Antigen processing and presentation_Homo sapiens_hsa046120.70336014
95Type I diabetes mellitus_Homo sapiens_hsa049400.69926818
96FoxO signaling pathway_Homo sapiens_hsa040680.69296899
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69060343
98Pertussis_Homo sapiens_hsa051330.68435083
99Phagosome_Homo sapiens_hsa041450.68091306
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67751631
101Tuberculosis_Homo sapiens_hsa051520.66653513
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66378804
103Hematopoietic cell lineage_Homo sapiens_hsa046400.65059265
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63702043
105RNA polymerase_Homo sapiens_hsa030200.63264445
106Galactose metabolism_Homo sapiens_hsa000520.63152817
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61821372
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61724083
109Glucagon signaling pathway_Homo sapiens_hsa049220.60483830
110Viral myocarditis_Homo sapiens_hsa054160.60449147
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.60397627
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59381594
113Pyrimidine metabolism_Homo sapiens_hsa002400.58876552
114mRNA surveillance pathway_Homo sapiens_hsa030150.58590495
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57165520
116Nucleotide excision repair_Homo sapiens_hsa034200.57149497
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56672091
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.55436247
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.55348303
120Basal transcription factors_Homo sapiens_hsa030220.54461615
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54264520
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53540098
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53513561
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.53474688
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53362851
126Spliceosome_Homo sapiens_hsa030400.50515152
127Starch and sucrose metabolism_Homo sapiens_hsa005000.50475658
128RNA degradation_Homo sapiens_hsa030180.50365708
129Alcoholism_Homo sapiens_hsa050340.48354053
130Renal cell carcinoma_Homo sapiens_hsa052110.48216639
131Focal adhesion_Homo sapiens_hsa045100.47238257
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47051591
133PPAR signaling pathway_Homo sapiens_hsa033200.47044261
134p53 signaling pathway_Homo sapiens_hsa041150.46935597
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45816507
136Legionellosis_Homo sapiens_hsa051340.45497578
137AMPK signaling pathway_Homo sapiens_hsa041520.45435827
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44905698
139Hepatitis C_Homo sapiens_hsa051600.44502859

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »