PANK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.90140174
2cardiac myofibril assembly (GO:0055003)4.39427354
3regulation of gamma-delta T cell differentiation (GO:0045586)4.24002781
4negative regulation of cell killing (GO:0031342)4.17880104
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17880104
6leukocyte aggregation (GO:0070486)4.05766983
7negative regulation of histone methylation (GO:0031061)3.99599917
8negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.98797157
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88198201
10myofibril assembly (GO:0030239)3.78743040
11cardiac muscle contraction (GO:0060048)3.78316622
12sarcomere organization (GO:0045214)3.75031255
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.71855659
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.71855659
15modulation by symbiont of host immune response (GO:0052553)3.71855659
16positive regulation by symbiont of host defense response (GO:0052509)3.71855659
17modulation by symbiont of host defense response (GO:0052031)3.71855659
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.71855659
19regulation of gamma-delta T cell activation (GO:0046643)3.69088404
20tricarboxylic acid cycle (GO:0006099)3.69000886
21oxaloacetate metabolic process (GO:0006107)3.65347720
22creatine metabolic process (GO:0006600)3.60527801
23peptidyl-arginine omega-N-methylation (GO:0035247)3.44505495
24DNA unwinding involved in DNA replication (GO:0006268)3.40186850
25negative regulation of RNA splicing (GO:0033119)3.34389742
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.27695027
27negative regulation of necroptotic process (GO:0060546)3.26480651
28response to muramyl dipeptide (GO:0032495)3.26081739
29translesion synthesis (GO:0019985)3.26034314
30actin-myosin filament sliding (GO:0033275)3.26029145
31muscle filament sliding (GO:0030049)3.26029145
32spliceosomal tri-snRNP complex assembly (GO:0000244)3.25350570
33cardiac muscle hypertrophy (GO:0003300)3.24402028
34peptidyl-lysine dimethylation (GO:0018027)3.23372320
35regulation of relaxation of muscle (GO:1901077)3.23084694
36mannose metabolic process (GO:0006013)3.20064346
37ribosomal small subunit assembly (GO:0000028)3.18346378
38positive thymic T cell selection (GO:0045059)3.17725142
39B cell receptor signaling pathway (GO:0050853)3.17380218
40negative regulation of mRNA processing (GO:0050686)3.16450679
41apoptotic process involved in morphogenesis (GO:0060561)3.14185023
42positive regulation of histone deacetylation (GO:0031065)3.13732629
43positive regulation of RNA splicing (GO:0033120)3.12218871
44regulation of NFAT protein import into nucleus (GO:0051532)3.11890801
45response to laminar fluid shear stress (GO:0034616)3.10176206
46response to interleukin-15 (GO:0070672)3.08233593
47T cell migration (GO:0072678)3.06416775
48striated muscle hypertrophy (GO:0014897)3.06105274
49tolerance induction (GO:0002507)3.05374747
50NADH metabolic process (GO:0006734)3.04518150
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03281224
52antigen processing and presentation of endogenous antigen (GO:0019883)3.02701326
53NIK/NF-kappaB signaling (GO:0038061)3.01910815
54regulation of type I interferon-mediated signaling pathway (GO:0060338)3.01817768
55intracellular estrogen receptor signaling pathway (GO:0030520)3.01093867
56striated muscle contraction (GO:0006941)2.99933487
57regulation of histone H3-K9 methylation (GO:0051570)2.98416111
58sodium ion export (GO:0071436)2.96373557
59IMP biosynthetic process (GO:0006188)2.96149896
60positive regulation of myotube differentiation (GO:0010831)2.95797591
61negative regulation of lymphocyte mediated immunity (GO:0002707)2.93654646
62regulation of interleukin-12 biosynthetic process (GO:0045075)2.93411093
63regulation of B cell receptor signaling pathway (GO:0050855)2.93238949
64cellular response to interleukin-15 (GO:0071350)2.92755563
65protein localization to endosome (GO:0036010)2.92611626
66oxygen transport (GO:0015671)2.92522137
67positive T cell selection (GO:0043368)2.91805408
68mRNA splice site selection (GO:0006376)2.91292780
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.90436678
70amino sugar catabolic process (GO:0046348)2.90069981
71regulation of necroptotic process (GO:0060544)2.87091432
72positive regulation of B cell differentiation (GO:0045579)2.86653357
73negative regulation of myotube differentiation (GO:0010832)2.86554839
74pre-miRNA processing (GO:0031054)2.85650724
75nuclear pore complex assembly (GO:0051292)2.84337196
76negative regulation of innate immune response (GO:0045824)2.84046441
77nuclear pore organization (GO:0006999)2.83594587
78Golgi transport vesicle coating (GO:0048200)2.83490850
79COPI coating of Golgi vesicle (GO:0048205)2.83490850
80positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.83477098
81regulation of B cell differentiation (GO:0045577)2.82727074
82negative regulation of T cell mediated immunity (GO:0002710)2.81984496
83regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81669298
84Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79020745
85regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78504975
86glycolytic process (GO:0006096)2.78155770
87respiratory burst (GO:0045730)2.77201250
88negative regulation of leukocyte mediated immunity (GO:0002704)2.75247855
89histone H2A acetylation (GO:0043968)2.74913168
90DNA duplex unwinding (GO:0032508)2.74440304
91DNA geometric change (GO:0032392)2.74390934
92regulation of interferon-beta biosynthetic process (GO:0045357)2.74135195
93IMP metabolic process (GO:0046040)2.73150576
94regulation of defense response to virus by virus (GO:0050690)2.71985939
95postreplication repair (GO:0006301)2.71887328
963-UTR-mediated mRNA stabilization (GO:0070935)2.71324924
97cellular response to interleukin-4 (GO:0071353)2.71091412
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71036569
99regulation of translational fidelity (GO:0006450)2.70879165
100cellular response to zinc ion (GO:0071294)2.68930390
101regulation of histone H3-K4 methylation (GO:0051569)2.68599803
102DNA strand elongation (GO:0022616)2.68093858
103negative regulation of mRNA metabolic process (GO:1903312)2.67749568
104cardiac muscle hypertrophy in response to stress (GO:0014898)2.67390067
105muscle hypertrophy in response to stress (GO:0003299)2.67390067
106cardiac muscle adaptation (GO:0014887)2.67390067
107protein localization to kinetochore (GO:0034501)2.66765846
108interferon-gamma production (GO:0032609)2.66592029
109DNA strand elongation involved in DNA replication (GO:0006271)2.66479376
110mitotic chromosome condensation (GO:0007076)2.66389533
111T cell selection (GO:0045058)2.66168237
112retinal cone cell development (GO:0046549)2.66038999
113histone H3-K4 trimethylation (GO:0080182)2.66002664
114adult heart development (GO:0007512)2.65784450
115sarcoplasmic reticulum calcium ion transport (GO:0070296)2.64924134
116peptidyl-arginine N-methylation (GO:0035246)2.64577204
117peptidyl-arginine methylation (GO:0018216)2.64577204
118regulation of sarcomere organization (GO:0060297)2.64369987
119detection of other organism (GO:0098543)2.64149867
120negative thymic T cell selection (GO:0045060)2.63359756
121negative regulation of erythrocyte differentiation (GO:0045647)2.62322171
122negative T cell selection (GO:0043383)2.62144745
123plasma membrane repair (GO:0001778)2.62033303
124macrophage activation involved in immune response (GO:0002281)2.61547492
125detection of bacterium (GO:0016045)2.60878235
126regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60066802
127retinoic acid receptor signaling pathway (GO:0048384)2.60020227
128thymic T cell selection (GO:0045061)2.59591818
129negative regulation of cell size (GO:0045792)2.59380269
130muscle hypertrophy (GO:0014896)2.57226170
131erythrocyte development (GO:0048821)2.57102858
132cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.56592807
133embryonic hemopoiesis (GO:0035162)2.56115080
134retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.55968495
135negative regulation of histone modification (GO:0031057)2.55882834
136regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.54975808
137alternative mRNA splicing, via spliceosome (GO:0000380)2.54244010
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53803671
139regulation of histone H3-K27 methylation (GO:0061085)2.53698226
140negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.52440749
141natural killer cell differentiation (GO:0001779)2.51800376
142histone arginine methylation (GO:0034969)2.51067594
143positive regulation of macrophage differentiation (GO:0045651)2.50937349
144histone H4 deacetylation (GO:0070933)2.50399193
145regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49953718
146epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49617182
147mitochondrial genome maintenance (GO:0000002)2.49527662
148antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48934764
149antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48934764
150rhodopsin mediated signaling pathway (GO:0016056)2.48413228
151negative regulation of potassium ion transmembrane transport (GO:1901380)2.48118453
152peptidyl-lysine methylation (GO:0018022)2.47944044
153positive regulation of synapse maturation (GO:0090129)2.47591819
154mitotic nuclear envelope disassembly (GO:0007077)2.47421323
155regulation of natural killer cell mediated immunity (GO:0002715)2.47207484
156regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.47207484
157negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47016774
158protoporphyrinogen IX metabolic process (GO:0046501)2.46750429
159negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.45550363
160DNA replication initiation (GO:0006270)2.45359848
161glycosphingolipid catabolic process (GO:0046479)2.44494740
162actomyosin structure organization (GO:0031032)2.44235951
163telomere maintenance via semi-conservative replication (GO:0032201)2.44152484
164skeletal muscle contraction (GO:0003009)2.44024157
165succinate metabolic process (GO:0006105)2.43798466
166actin-mediated cell contraction (GO:0070252)2.43453755
167response to interleukin-4 (GO:0070670)2.39751039
168negative regulation of necrotic cell death (GO:0060547)2.39257584
169germinal center formation (GO:0002467)2.37790373
170gluconeogenesis (GO:0006094)2.36362147
171glucose 6-phosphate metabolic process (GO:0051156)2.35938310
172mitochondrial fusion (GO:0008053)2.35661014
173negative regulation of interleukin-12 production (GO:0032695)2.35366080
1742-oxoglutarate metabolic process (GO:0006103)2.34024452
175cellular protein complex localization (GO:0034629)2.33632928
176tricarboxylic acid metabolic process (GO:0072350)2.32573846
177regulation of necrotic cell death (GO:0010939)2.31037181
178regulation of ARF protein signal transduction (GO:0032012)2.30809804
179monosaccharide biosynthetic process (GO:0046364)2.30461414

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.95393880
2MYC_22102868_ChIP-Seq_BL_Human4.54953417
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51347118
4CIITA_25753668_ChIP-Seq_RAJI_Human3.42376298
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.26159131
6VDR_21846776_ChIP-Seq_THP-1_Human2.83671039
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75897498
8GATA1_22025678_ChIP-Seq_K562_Human2.71873041
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66242296
10* MYC_18555785_ChIP-Seq_MESCs_Mouse2.20791642
11DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.18509051
12* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17541487
13TCF7_22412390_ChIP-Seq_EML_Mouse2.16701995
14* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06786234
15MAF_26560356_Chip-Seq_TH1_Human2.02100804
16TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98636639
17* KDM2B_26808549_Chip-Seq_DND41_Human1.98109635
18UTX_26944678_Chip-Seq_JUKART_Human1.97178806
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95894935
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93065198
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91110364
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91098242
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88234188
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81931351
25SCL_19346495_ChIP-Seq_HPC-7_Human1.80741906
26* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.80500447
27XRN2_22483619_ChIP-Seq_HELA_Human1.77352559
28* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76914865
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76904838
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71368257
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70613267
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68277360
33RACK7_27058665_Chip-Seq_MCF-7_Human1.65322315
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.65005486
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63983762
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61016586
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59064431
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57858644
39* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57769057
40* SA1_27219007_Chip-Seq_ERYTHROID_Human1.56792169
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55572321
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55350374
43FOXP3_21729870_ChIP-Seq_TREG_Human1.54152761
44MYB_26560356_Chip-Seq_TH2_Human1.52395616
45* MYB_26560356_Chip-Seq_TH1_Human1.51297284
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50764158
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50013855
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49777678
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49397252
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48532099
51RUNX_20019798_ChIP-Seq_JUKART_Human1.47869090
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.47315313
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.46650248
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.45585701
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44971211
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.44782051
57* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42392161
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42299881
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41914514
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39797776
61VDR_24763502_ChIP-Seq_THP-1_Human1.39309108
62* ETS1_20019798_ChIP-Seq_JURKAT_Human1.39184855
63* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38558096
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37840687
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35902703
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34765738
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33224772
68SPI1_23127762_ChIP-Seq_K562_Human1.33222702
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32931832
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.32142816
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.32050609
72SMC4_20622854_ChIP-Seq_HELA_Human1.31879346
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30409940
74* MAF_26560356_Chip-Seq_TH2_Human1.30102804
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29134905
76* KDM2B_26808549_Chip-Seq_K562_Human1.29043210
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27580678
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.27483978
79LXR_22292898_ChIP-Seq_THP-1_Human1.27328273
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26897608
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26658476
82VDR_23849224_ChIP-Seq_CD4+_Human1.26608569
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25881651
84* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25134787
85* KDM5A_27292631_Chip-Seq_BREAST_Human1.24916327
86* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24424154
87BCOR_27268052_Chip-Seq_Bcells_Human1.24281523
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23823593
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23462989
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22782637
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22448511
92* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22081069
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21454013
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21265321
95GATA1_19941826_ChIP-Seq_K562_Human1.18855223
96P68_20966046_ChIP-Seq_HELA_Human1.17254553
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.17036316
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15633181
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15329939
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15181140
101KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15057727
102IRF8_22096565_ChIP-ChIP_GC-B_Human1.15011209
103* GABP_19822575_ChIP-Seq_HepG2_Human1.14899584
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13470332
105* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13286296
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12359191
107* CREB1_26743006_Chip-Seq_LNCaP_Human1.12143536
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11264444
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10975194
110HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10859739
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.09379093
112CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09304071
113SPI1_23547873_ChIP-Seq_NB4_Human1.09184632
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07447275
115KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07259107
116BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07064787
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.07035559
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06742304
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06568383
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06045411
121STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05612388
122JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05394937
123* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05323570
124GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05036006
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.04479741
126CTCF_21964334_Chip-Seq_Bcells_Human1.04432571
127* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04353211
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02873137
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02845031
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02251975
131* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99988307
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99506418
133* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99315325
134BCL6_27268052_Chip-Seq_Bcells_Human0.99247141
135NCOR1_26117541_ChIP-Seq_K562_Human0.98989629
136TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97687667
137NOTCH1_21737748_ChIP-Seq_TLL_Human0.97566865
138RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97183009
139* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96996125
140MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95760005
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94512423
142RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94454705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.57554494
2MP0003646_muscle_fatigue3.61966565
3MP0004084_abnormal_cardiac_muscle3.25012677
4MP0000751_myopathy3.23064856
5MP0003436_decreased_susceptibility_to3.11398288
6MP0008260_abnormal_autophagy2.91098891
7MP0004215_abnormal_myocardial_fiber2.89812059
8MP0000749_muscle_degeneration2.81237165
9MP0002837_dystrophic_cardiac_calcinosis2.63178506
10MP0002396_abnormal_hematopoietic_system2.61416076
11MP0005058_abnormal_lysosome_morphology2.61333489
12MP0010094_abnormal_chromosome_stability2.29707792
13MP0004036_abnormal_muscle_relaxation2.25201664
14MP0003191_abnormal_cellular_cholesterol2.24381176
15MP0003763_abnormal_thymus_physiology2.20767554
16MP0003303_peritoneal_inflammation2.19882007
17MP0004087_abnormal_muscle_fiber2.11647263
18MP0003329_amyloid_beta_deposits2.11617011
19MP0005330_cardiomyopathy2.09972692
20MP0003656_abnormal_erythrocyte_physiolo2.08324347
21MP0004145_abnormal_muscle_electrophysio2.00422544
22MP0003111_abnormal_nucleus_morphology1.96711888
23MP0009333_abnormal_splenocyte_physiolog1.90527032
24MP0004185_abnormal_adipocyte_glucose1.89767000
25MP0004858_abnormal_nervous_system1.88806860
26MP0003724_increased_susceptibility_to1.87989996
27MP0004808_abnormal_hematopoietic_stem1.87722390
28MP0005551_abnormal_eye_electrophysiolog1.87584029
29MP0009840_abnormal_foam_cell1.86245736
30MP0008961_abnormal_basal_metabolism1.83282048
31MP0003077_abnormal_cell_cycle1.83263815
32MP0002269_muscular_atrophy1.82255708
33MP0004510_myositis1.76314994
34MP0005423_abnormal_somatic_nervous1.75932873
35MP0010630_abnormal_cardiac_muscle1.74611348
36MP0002398_abnormal_bone_marrow1.73098117
37MP0005025_abnormal_response_to1.70703020
38MP0002419_abnormal_innate_immunity1.66045880
39MP0002106_abnormal_muscle_physiology1.65904757
40MP0004147_increased_porphyrin_level1.65626552
41MP0003705_abnormal_hypodermis_morpholog1.64468582
42MP0005000_abnormal_immune_tolerance1.62309013
43MP0008057_abnormal_DNA_replication1.61412384
44MP0003300_gastrointestinal_ulcer1.60483904
45MP0004130_abnormal_muscle_cell1.60304156
46MP0003693_abnormal_embryo_hatching1.59483199
47MP0000747_muscle_weakness1.57192929
48MP0006035_abnormal_mitochondrial_morpho1.56801513
49MP0003828_pulmonary_edema1.55946644
50MP0000703_abnormal_thymus_morphology1.55810992
51MP0001800_abnormal_humoral_immune1.55492021
52MP0004233_abnormal_muscle_weight1.54433519
53MP0004859_abnormal_synaptic_plasticity1.52755365
54MP0000759_abnormal_skeletal_muscle1.52111685
55MP0008775_abnormal_heart_ventricle1.50626558
56MP0004947_skin_inflammation1.49145062
57MP0003137_abnormal_impulse_conducting1.46489380
58MP0003123_paternal_imprinting1.44693391
59MP0005671_abnormal_response_to1.43756583
60MP0006036_abnormal_mitochondrial_physio1.41121765
61MP0002722_abnormal_immune_system1.39323552
62MP0000689_abnormal_spleen_morphology1.34978933
63MP0005385_cardiovascular_system_phenoty1.34262754
64MP0001544_abnormal_cardiovascular_syste1.34262754
65MP0005253_abnormal_eye_physiology1.31508644
66MP0005397_hematopoietic_system_phenotyp1.31013645
67MP0001545_abnormal_hematopoietic_system1.31013645
68MP0000569_abnormal_digit_pigmentation1.30257060
69MP0003221_abnormal_cardiomyocyte_apopto1.29013611
70MP0001533_abnormal_skeleton_physiology1.28357701
71MP0000604_amyloidosis1.28269661
72MP0002972_abnormal_cardiac_muscle1.28103359
73MP0004957_abnormal_blastocyst_morpholog1.27800133
74MP0008569_lethality_at_weaning1.26278967
75MP0004484_altered_response_of1.26054137
76MP0000733_abnormal_muscle_development1.25830501
77MP0000750_abnormal_muscle_regeneration1.24578315
78MP0003172_abnormal_lysosome_physiology1.23643452
79MP0005620_abnormal_muscle_contractility1.21785243
80MP0003787_abnormal_imprinting1.21659547
81MP0004085_abnormal_heartbeat1.20758937
82MP0001835_abnormal_antigen_presentation1.20626514
83MP0002429_abnormal_blood_cell1.20252580
84MP0000685_abnormal_immune_system1.20143313
85MP0008877_abnormal_DNA_methylation1.19927434
86MP0003878_abnormal_ear_physiology1.17522085
87MP0005377_hearing/vestibular/ear_phenot1.17522085
88MP0009785_altered_susceptibility_to1.17300765
89MP0002405_respiratory_system_inflammati1.16617917
90MP0000716_abnormal_immune_system1.14608381
91MP0002420_abnormal_adaptive_immunity1.12280072
92MP0005369_muscle_phenotype1.11550061
93MP0006072_abnormal_retinal_apoptosis1.10337279
94MP0008007_abnormal_cellular_replicative1.09328113
95MP0001819_abnormal_immune_cell1.08511158
96MP0002127_abnormal_cardiovascular_syste1.06787367
97MP0002332_abnormal_exercise_endurance1.06235163
98MP0002452_abnormal_antigen_presenting1.04384455
99MP0000266_abnormal_heart_morphology1.03651549
100MP0000858_altered_metastatic_potential1.03360237
101MP0002234_abnormal_pharynx_morphology1.03359558
102MP0003121_genomic_imprinting1.02892149
103MP0003567_abnormal_fetal_cardiomyocyte1.02510812
104MP0002653_abnormal_ependyma_morphology1.02244686
105MP0001730_embryonic_growth_arrest1.01014368
106MP0002723_abnormal_immune_serum0.99408611
107MP0008058_abnormal_DNA_repair0.98571763
108MP0001849_ear_inflammation0.98111309
109MP0001873_stomach_inflammation0.97659337
110MP0000313_abnormal_cell_death0.97229788
111MP0002080_prenatal_lethality0.93948006
112MP0003984_embryonic_growth_retardation0.93929455
113MP0005083_abnormal_biliary_tract0.92777721
114MP0010352_gastrointestinal_tract_polyps0.92751623
115MP0000678_abnormal_parathyroid_gland0.91978474
116MP0002088_abnormal_embryonic_growth/wei0.90419453
117MP0001790_abnormal_immune_system0.89552253
118MP0005387_immune_system_phenotype0.89552253
119MP0005310_abnormal_salivary_gland0.89280354
120MP0005464_abnormal_platelet_physiology0.89181459
121MP0000350_abnormal_cell_proliferation0.89110384
122MP0000343_altered_response_to0.88730042
123MP0002909_abnormal_adrenal_gland0.88626697
124MP0003866_abnormal_defecation0.88372012
125MP0001853_heart_inflammation0.87870286
126MP0005670_abnormal_white_adipose0.87490787
127MP0005076_abnormal_cell_differentiation0.86748509
128MP0006054_spinal_hemorrhage0.85418221
129MP0000465_gastrointestinal_hemorrhage0.83132010
130MP0009278_abnormal_bone_marrow0.82689920
131MP0001727_abnormal_embryo_implantation0.82621572
132MP0001672_abnormal_embryogenesis/_devel0.79753349
133MP0005380_embryogenesis_phenotype0.79753349
134MP0005666_abnormal_adipose_tissue0.79441147
135MP0003879_abnormal_hair_cell0.77870730
136MP0008995_early_reproductive_senescence0.77649054
137MP0005266_abnormal_metabolism0.77333335
138MP0001845_abnormal_inflammatory_respons0.76739144
139MP0003091_abnormal_cell_migration0.75917760
140MP0001851_eye_inflammation0.75813491
141MP0002148_abnormal_hypersensitivity_rea0.74865518
142MP0003045_fibrosis0.74864345
143MP0005621_abnormal_cell_physiology0.72938205
144MP0005375_adipose_tissue_phenotype0.72905850
145MP0006082_CNS_inflammation0.72396687
146MP0003786_premature_aging0.72388198
147MP0008469_abnormal_protein_level0.70389737
148MP0005623_abnormal_meninges_morphology0.69499668
149MP0003566_abnormal_cell_adhesion0.69002700
150MP0001348_abnormal_lacrimal_gland0.68901056

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.78988394
2Muscle fiber inclusion bodies (HP:0100299)4.64152211
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.54087284
4Exercise-induced muscle cramps (HP:0003710)4.51949920
5Nemaline bodies (HP:0003798)4.48160095
6Exercise-induced myalgia (HP:0003738)4.14126899
7Myopathic facies (HP:0002058)4.09338502
8Eczematoid dermatitis (HP:0000976)3.75363909
9Myoglobinuria (HP:0002913)3.63977628
10Sudden death (HP:0001699)3.62062489
11Type 1 muscle fiber predominance (HP:0003803)3.55560442
12Distal lower limb muscle weakness (HP:0009053)3.51578662
13Central scotoma (HP:0000603)3.40028170
14Bony spicule pigmentary retinopathy (HP:0007737)3.31195461
15Hyperacusis (HP:0010780)3.27989058
16Abnormality of the left ventricular outflow tract (HP:0011103)3.26124272
17Subaortic stenosis (HP:0001682)3.26124272
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.25288693
19Calf muscle hypertrophy (HP:0008981)3.14973303
20Abnormality of skeletal muscle fiber size (HP:0012084)3.14392945
21Abnormality of the fingertips (HP:0001211)3.08949536
22Rhabdomyolysis (HP:0003201)3.03819918
23Atrial fibrillation (HP:0005110)3.02241757
24Muscle fiber splitting (HP:0003555)3.01118647
25Scotoma (HP:0000575)2.94242807
26Progressive muscle weakness (HP:0003323)2.93736476
27Ragged-red muscle fibers (HP:0003200)2.89955091
28Muscle hypertrophy of the lower extremities (HP:0008968)2.82560557
29Increased variability in muscle fiber diameter (HP:0003557)2.82553259
30Difficulty climbing stairs (HP:0003551)2.78785823
31Primary atrial arrhythmia (HP:0001692)2.76896638
32Supraventricular tachycardia (HP:0004755)2.75748881
33Abnormal rod and cone electroretinograms (HP:0008323)2.74115165
34Cholecystitis (HP:0001082)2.73150526
35Abnormal gallbladder physiology (HP:0012438)2.73150526
36Supraventricular arrhythmia (HP:0005115)2.71362962
37Abnormality of glycolipid metabolism (HP:0010969)2.70057505
38Abnormality of liposaccharide metabolism (HP:0010968)2.70057505
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.70057505
40Pendular nystagmus (HP:0012043)2.69845396
41Lipoatrophy (HP:0100578)2.63045130
42Verrucae (HP:0200043)2.61592203
43Papilloma (HP:0012740)2.61592203
44Dysmetric saccades (HP:0000641)2.56699682
45Ventricular tachycardia (HP:0004756)2.54373162
46Abnormality of macrophages (HP:0004311)2.52069271
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49765997
48Myositis (HP:0100614)2.46971248
49IgM deficiency (HP:0002850)2.46140451
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.45589145
51EMG: myopathic abnormalities (HP:0003458)2.45428596
52Recurrent bacterial skin infections (HP:0005406)2.44795803
53Insomnia (HP:0100785)2.42862114
54Abnormality of the lower motor neuron (HP:0002366)2.42586935
55T lymphocytopenia (HP:0005403)2.42209893
56Abnormality of the calf musculature (HP:0001430)2.41330357
57Recurrent abscess formation (HP:0002722)2.40697824
58Agammaglobulinemia (HP:0004432)2.39547510
59Limb-girdle muscle atrophy (HP:0003797)2.39264189
60Prolonged QT interval (HP:0001657)2.37258789
61Slow saccadic eye movements (HP:0000514)2.36581671
62Vertebral compression fractures (HP:0002953)2.34599254
63Obstructive lung disease (HP:0006536)2.33676189
64Chronic obstructive pulmonary disease (HP:0006510)2.33676189
65Reticulocytosis (HP:0001923)2.31426777
66Ulnar deviation of the wrist (HP:0003049)2.30707764
67Orchitis (HP:0100796)2.29434590
68Ependymoma (HP:0002888)2.29132719
69Cholelithiasis (HP:0001081)2.27693628
70Vertebral arch anomaly (HP:0008438)2.26397880
71Gastrointestinal stroma tumor (HP:0100723)2.25757046
72Difficulty running (HP:0009046)2.25259602
73Pigmentary retinal degeneration (HP:0001146)2.23904572
74Poikilocytosis (HP:0004447)2.23716795
75Recurrent viral infections (HP:0004429)2.22921639
76Abnormal number of erythroid precursors (HP:0012131)2.22540717
77Stridor (HP:0010307)2.22162122
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21205901
79Obsessive-compulsive behavior (HP:0000722)2.20933172
80Achilles tendon contracture (HP:0001771)2.20271880
81Panhypogammaglobulinemia (HP:0003139)2.19619318
82Elfin facies (HP:0004428)2.14923998
83Dilated cardiomyopathy (HP:0001644)2.14240939
84Progressive external ophthalmoplegia (HP:0000590)2.12295841
85Basal cell carcinoma (HP:0002671)2.10940825
86Myotonia (HP:0002486)2.09826190
87Broad face (HP:0000283)2.09173376
88Facial diplegia (HP:0001349)2.08291534
89Bundle branch block (HP:0011710)2.07677110
90Chorioretinal atrophy (HP:0000533)2.07599175
91Cerebral aneurysm (HP:0004944)2.07102599
92Gastrointestinal infarctions (HP:0005244)2.06851386
93Abnormality of T cell number (HP:0011839)2.06427411
94B lymphocytopenia (HP:0010976)2.06132926
95Abnormality of B cell number (HP:0010975)2.06132926
96Distal lower limb amyotrophy (HP:0008944)2.05058211
97Abnormality of cells of the erythroid lineage (HP:0012130)2.04601929
98Elevated erythrocyte sedimentation rate (HP:0003565)2.03109316
99Scapular winging (HP:0003691)2.01959574
100Chest pain (HP:0100749)2.01700808
101Hypoplasia of the thymus (HP:0000778)1.99669052
102Broad palm (HP:0001169)1.99602174
103Volvulus (HP:0002580)1.99449601
104Round ear (HP:0100830)1.98224078
105Recurrent bronchitis (HP:0002837)1.98133730
106Distal arthrogryposis (HP:0005684)1.97281097
107Increased connective tissue (HP:0009025)1.96234188
108Athetosis (HP:0002305)1.96199350
109Increased nuchal translucency (HP:0010880)1.95305885
110Foot dorsiflexor weakness (HP:0009027)1.95018022
111Upper limb amyotrophy (HP:0009129)1.94945066
112Distal upper limb amyotrophy (HP:0007149)1.94945066
113Abnormality of reticulocytes (HP:0004312)1.94299922
114Pointed chin (HP:0000307)1.93841038
115Mildly elevated creatine phosphokinase (HP:0008180)1.93499604
116Obstructive sleep apnea (HP:0002870)1.92504861
117Neck muscle weakness (HP:0000467)1.92090239
118Lymphopenia (HP:0001888)1.91951547
119Pancreatic islet-cell hyperplasia (HP:0004510)1.91873006
120Constricted visual fields (HP:0001133)1.89839001
121Short 4th metacarpal (HP:0010044)1.89755297
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89755297
123Neuronal loss in central nervous system (HP:0002529)1.89702999
124Abnormality of the foot musculature (HP:0001436)1.89583561
125Frequent falls (HP:0002359)1.88421858
126Cortical dysplasia (HP:0002539)1.88309307
127Mediastinal lymphadenopathy (HP:0100721)1.86860955
128Type II diabetes mellitus (HP:0005978)1.85977714
129Acanthocytosis (HP:0001927)1.85716158
130Abnormal large intestine physiology (HP:0012700)1.84812894
131Bowel incontinence (HP:0002607)1.84750649
132Interstitial pulmonary disease (HP:0006530)1.84323230
133Abnormality of cells of the lymphoid lineage (HP:0012140)1.83997977
134Abnormality of the calcaneus (HP:0008364)1.83227518
135Centrally nucleated skeletal muscle fibers (HP:0003687)1.82551652
136Hypoproteinemia (HP:0003075)1.82479877
137Attenuation of retinal blood vessels (HP:0007843)1.82425692
138Optic neuritis (HP:0100653)1.82020285
139Retrobulbar optic neuritis (HP:0100654)1.82020285
140Hyporeflexia of lower limbs (HP:0002600)1.81962723
141Abnormal gallbladder morphology (HP:0012437)1.81641932
142Diaphragmatic weakness (HP:0009113)1.81310001
143Abnormality of the Achilles tendon (HP:0005109)1.80747642
144Cellulitis (HP:0100658)1.80540468
145Fatigue (HP:0012378)1.80338567
146Hypertensive crisis (HP:0100735)1.79840788
147Colitis (HP:0002583)1.78891832
148Thyroiditis (HP:0100646)1.78848333
149Resting tremor (HP:0002322)1.78288736
150Truncus arteriosus (HP:0001660)1.77863493
151Muscle stiffness (HP:0003552)1.76696887
152Palpitations (HP:0001962)1.76257006
153EMG: neuropathic changes (HP:0003445)1.75844071
154Upper motor neuron abnormality (HP:0002127)1.75753904
155Lower limb amyotrophy (HP:0007210)1.75495086
156Ventricular arrhythmia (HP:0004308)1.75198310
157Severe combined immunodeficiency (HP:0004430)1.74421429
158Apathy (HP:0000741)1.73884675
159Left ventricular hypertrophy (HP:0001712)1.73630234
160Dislocated radial head (HP:0003083)1.73521347
161Diminished motivation (HP:0000745)1.71933527
162Prominent nose (HP:0000448)1.71930518
163Dysostosis multiplex (HP:0000943)1.71303825
164Increased IgM level (HP:0003496)1.70981608
165Limb hypertonia (HP:0002509)1.70954992
166Petechiae (HP:0000967)1.70667275
167Abnormality of the gallbladder (HP:0005264)1.69870640
168Ventricular fibrillation (HP:0001663)1.68630279
169Broad distal phalanx of finger (HP:0009836)1.68187162
170Asymmetric septal hypertrophy (HP:0001670)1.68023877
171Easy fatigability (HP:0003388)1.67704581
172Combined immunodeficiency (HP:0005387)1.66774214
173Gastrointestinal inflammation (HP:0004386)1.65068480
174Rimmed vacuoles (HP:0003805)1.65025788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.74457281
2MAP4K13.61880049
3TTN3.49276620
4SMG13.18818201
5EEF2K3.07937048
6NEK12.33035041
7MAP3K102.31034158
8IRAK42.30714417
9EPHB12.29897852
10BRD42.27940778
11FLT32.16230254
12CDC72.03870418
13TSSK62.02504975
14TRIB31.97030924
15OBSCN1.76947386
16ICK1.72592707
17MAP2K31.68328262
18MAP3K71.66383433
19MAP3K131.64652063
20SIK21.59996593
21MARK21.58276130
22IRAK31.55156712
23CDK121.53147954
24EPHA31.52432755
25BLK1.51146957
26STK101.49863670
27RIPK11.48136215
28MAP3K141.42520192
29KIT1.42415975
30TESK21.41915251
31NEK21.38077217
32TGFBR21.35693270
33MAP3K111.34488231
34KSR21.34243214
35BTK1.18974856
36GRK61.18261839
37DYRK1B1.14908300
38CSK1.14235685
39CCNB11.14075533
40DAPK11.11282258
41TGFBR11.09885401
42RPS6KB21.09436366
43BUB11.03536576
44SCYL21.03445043
45BRSK11.02286918
46TAOK31.00817770
47SYK1.00388823
48PRKCH1.00250101
49CSF1R0.99527570
50ATR0.99328301
51JAK30.99321930
52CDK40.98708864
53SGK30.97940458
54MAP3K30.97497103
55MARK30.96621959
56MYLK0.96512354
57TYK20.93903853
58MAPK120.93542027
59KDR0.93287050
60BRSK20.93171090
61PIM20.92094703
62PHKG20.91448926
63PHKG10.91448926
64MAP3K10.91182480
65RIPK40.89514540
66CLK10.87800881
67FGR0.85442668
68ALK0.84957840
69RPS6KA60.84094202
70RPS6KL10.83131529
71RPS6KC10.83131529
72IRAK20.80425114
73STK40.79721473
74ZAP700.79075197
75ERN10.78789652
76DMPK0.78124554
77CDC42BPA0.77352700
78LRRK20.76356727
79MAPKAPK30.76219587
80SGK20.75859619
81TAOK20.74510952
82ARAF0.74123816
83TXK0.73815479
84TNK20.73205532
85CAMK40.73085058
86JAK10.71643975
87MAPK110.71443646
88PRPF4B0.71282869
89NME20.70949871
90PASK0.70525336
91ITK0.70272555
92SIK30.70133937
93MAP3K80.69746720
94RAF10.66912340
95TLK10.65452726
96CAMK10.64573023
97RPS6KA40.63935294
98PAK40.63758502
99PTK60.62707706
100RPS6KA20.62563481
101PDK30.61592822
102PDK40.61592822
103TESK10.60098525
104CAMKK20.59993783
105BCKDK0.59598484
106PRKD20.59429241
107SIK10.59215954
108HCK0.57472366
109LCK0.57091845
110FGFR40.56327549
111HIPK20.55594812
112CAMK1D0.54652557
113CHEK10.53046147
114PRKD10.52271616
115TBK10.51942217
116BRAF0.51370311
117PDPK10.51058964
118NME10.50587498
119AURKA0.49668192
120MAPK70.48496437
121MATK0.48410922
122MAP2K20.48266735
123NEK90.48079480
124IKBKE0.47965872
125WEE10.47470476
126MTOR0.47262113
127PDK10.46742404
128MOS0.45843967
129LIMK10.44471673
130PIM10.44241704
131PINK10.44116580
132STK160.44093168
133LYN0.43408059
134CDK20.43351216
135TAOK10.43248207
136PRKD30.42815943
137PRKAA10.40869262
138FES0.39592828
139PRKDC0.39152324
140AURKB0.36666033
141CAMKK10.36658081
142JAK20.36405363
143AKT20.36016748
144MAP3K40.35573615

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.65365500
2Phototransduction_Homo sapiens_hsa047443.34884779
3Other glycan degradation_Homo sapiens_hsa005112.92444489
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.83607260
5DNA replication_Homo sapiens_hsa030302.43322694
6Primary immunodeficiency_Homo sapiens_hsa053402.29108477
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26325574
8Fructose and mannose metabolism_Homo sapiens_hsa000511.93916259
9Spliceosome_Homo sapiens_hsa030401.87370914
10B cell receptor signaling pathway_Homo sapiens_hsa046621.81256842
11Base excision repair_Homo sapiens_hsa034101.81045261
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80334922
13Dilated cardiomyopathy_Homo sapiens_hsa054141.79836724
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74593809
15Mismatch repair_Homo sapiens_hsa034301.71769887
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.70887507
17Pentose phosphate pathway_Homo sapiens_hsa000301.70323280
18Sulfur relay system_Homo sapiens_hsa041221.65351975
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45131650
20Carbon metabolism_Homo sapiens_hsa012001.41895848
21Cardiac muscle contraction_Homo sapiens_hsa042601.41175048
22mRNA surveillance pathway_Homo sapiens_hsa030151.40039027
23Shigellosis_Homo sapiens_hsa051311.36737473
24Lysine degradation_Homo sapiens_hsa003101.33986502
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32562484
26Biosynthesis of amino acids_Homo sapiens_hsa012301.27012407
27RNA degradation_Homo sapiens_hsa030181.24382646
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22980488
29Non-homologous end-joining_Homo sapiens_hsa034501.20278388
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17902419
31Hepatitis B_Homo sapiens_hsa051611.17602839
32Bladder cancer_Homo sapiens_hsa052191.15352261
33Glucagon signaling pathway_Homo sapiens_hsa049221.15218119
34Apoptosis_Homo sapiens_hsa042101.14221706
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.13453824
36Type II diabetes mellitus_Homo sapiens_hsa049301.13000284
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.09867245
38T cell receptor signaling pathway_Homo sapiens_hsa046601.09147558
39mTOR signaling pathway_Homo sapiens_hsa041501.07368612
40Insulin resistance_Homo sapiens_hsa049311.06635762
41Olfactory transduction_Homo sapiens_hsa047401.06586619
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05868386
43Tuberculosis_Homo sapiens_hsa051521.05476431
44Legionellosis_Homo sapiens_hsa051341.05128945
45Non-small cell lung cancer_Homo sapiens_hsa052231.04829194
46Thyroid cancer_Homo sapiens_hsa052161.03361562
47Acute myeloid leukemia_Homo sapiens_hsa052211.03205716
48RNA transport_Homo sapiens_hsa030131.03104199
49Salmonella infection_Homo sapiens_hsa051321.01561445
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01054423
51HIF-1 signaling pathway_Homo sapiens_hsa040661.00412783
52TNF signaling pathway_Homo sapiens_hsa046680.99777058
53Insulin signaling pathway_Homo sapiens_hsa049100.96097986
54Toxoplasmosis_Homo sapiens_hsa051450.95480114
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95251395
56Lysosome_Homo sapiens_hsa041420.93881536
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93868179
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93393384
59Chronic myeloid leukemia_Homo sapiens_hsa052200.93075606
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93041739
61Viral myocarditis_Homo sapiens_hsa054160.90939240
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.89864552
63Herpes simplex infection_Homo sapiens_hsa051680.89501305
64Circadian rhythm_Homo sapiens_hsa047100.89488876
65Endocytosis_Homo sapiens_hsa041440.89155062
66Oxytocin signaling pathway_Homo sapiens_hsa049210.88939736
67Cell cycle_Homo sapiens_hsa041100.88511357
68GnRH signaling pathway_Homo sapiens_hsa049120.88028012
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87301514
70HTLV-I infection_Homo sapiens_hsa051660.86552775
71One carbon pool by folate_Homo sapiens_hsa006700.86286334
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83217352
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83190464
74Long-term potentiation_Homo sapiens_hsa047200.83178552
75Morphine addiction_Homo sapiens_hsa050320.82767545
76Circadian entrainment_Homo sapiens_hsa047130.80798119
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80014042
78Systemic lupus erythematosus_Homo sapiens_hsa053220.79863784
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79325392
80Epstein-Barr virus infection_Homo sapiens_hsa051690.78806987
81Osteoclast differentiation_Homo sapiens_hsa043800.78309433
82Hepatitis C_Homo sapiens_hsa051600.77818808
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77619172
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.76967573
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76819361
86Measles_Homo sapiens_hsa051620.76525001
87ErbB signaling pathway_Homo sapiens_hsa040120.76376773
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74971166
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73946792
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.72790523
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72241957
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72231626
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71277821
94Nucleotide excision repair_Homo sapiens_hsa034200.71249020
95Calcium signaling pathway_Homo sapiens_hsa040200.70874892
96Malaria_Homo sapiens_hsa051440.69584568
97Antigen processing and presentation_Homo sapiens_hsa046120.69558703
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67181035
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67086451
100Colorectal cancer_Homo sapiens_hsa052100.66684398
101Homologous recombination_Homo sapiens_hsa034400.66449756
102Viral carcinogenesis_Homo sapiens_hsa052030.66278727
103Gastric acid secretion_Homo sapiens_hsa049710.65389434
104Prolactin signaling pathway_Homo sapiens_hsa049170.64818650
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.63580944
106AMPK signaling pathway_Homo sapiens_hsa041520.63236724
107Hematopoietic cell lineage_Homo sapiens_hsa046400.63026764
108Oocyte meiosis_Homo sapiens_hsa041140.62513050
109Pyruvate metabolism_Homo sapiens_hsa006200.62017136
110Renal cell carcinoma_Homo sapiens_hsa052110.59947213
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59797308
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.59548490
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.58605053
114Small cell lung cancer_Homo sapiens_hsa052220.58011672
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.57449340
116Platelet activation_Homo sapiens_hsa046110.57075399
117Pyrimidine metabolism_Homo sapiens_hsa002400.56919398
118VEGF signaling pathway_Homo sapiens_hsa043700.56687242
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.56357716
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56125810
121Alcoholism_Homo sapiens_hsa050340.55577246
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55086798
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54619139
124Prion diseases_Homo sapiens_hsa050200.54227535
125Influenza A_Homo sapiens_hsa051640.53466830
126Endometrial cancer_Homo sapiens_hsa052130.52612049
127Notch signaling pathway_Homo sapiens_hsa043300.52407493
128Galactose metabolism_Homo sapiens_hsa000520.52119865
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51488656
130Purine metabolism_Homo sapiens_hsa002300.50467509
131Pancreatic cancer_Homo sapiens_hsa052120.50206596
132Insulin secretion_Homo sapiens_hsa049110.49881956
133Glioma_Homo sapiens_hsa052140.48525949
134Chemokine signaling pathway_Homo sapiens_hsa040620.46943580
135Leishmaniasis_Homo sapiens_hsa051400.45651091
136MAPK signaling pathway_Homo sapiens_hsa040100.45564151
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45205496
138Inositol phosphate metabolism_Homo sapiens_hsa005620.45141381
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44869847
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44838764
141FoxO signaling pathway_Homo sapiens_hsa040680.44812671

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