PANO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.17316068
2negative regulation of telomere maintenance (GO:0032205)5.17940954
3detection of light stimulus involved in visual perception (GO:0050908)4.87544129
4detection of light stimulus involved in sensory perception (GO:0050962)4.87544129
5response to pheromone (GO:0019236)4.48341815
6DNA deamination (GO:0045006)4.47023351
7mitotic cell cycle arrest (GO:0071850)4.26964054
8cellular response to ATP (GO:0071318)4.22523347
9negative regulation of cell aging (GO:0090344)4.08355184
10respiratory chain complex IV assembly (GO:0008535)3.83126889
11L-fucose catabolic process (GO:0042355)3.82995338
12fucose catabolic process (GO:0019317)3.82995338
13L-fucose metabolic process (GO:0042354)3.82995338
14preassembly of GPI anchor in ER membrane (GO:0016254)3.77147257
15piRNA metabolic process (GO:0034587)3.62938775
16axoneme assembly (GO:0035082)3.58708044
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.56175378
18NADH dehydrogenase complex assembly (GO:0010257)3.56175378
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56175378
20meiotic chromosome segregation (GO:0045132)3.55757831
21protein complex biogenesis (GO:0070271)3.53134401
22regulation of telomere maintenance (GO:0032204)3.49744361
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48827594
24transepithelial transport (GO:0070633)3.48203239
25cytochrome complex assembly (GO:0017004)3.45953427
26regulation of telomere maintenance via telomerase (GO:0032210)3.38267728
27DNA damage induced protein phosphorylation (GO:0006975)3.36992866
28indole-containing compound catabolic process (GO:0042436)3.35482656
29indolalkylamine catabolic process (GO:0046218)3.35482656
30tryptophan catabolic process (GO:0006569)3.35482656
31cellular ketone body metabolic process (GO:0046950)3.28972550
32positive regulation of heat generation (GO:0031652)3.28284469
33epithelial cilium movement (GO:0003351)3.25649969
34mitochondrial respiratory chain complex assembly (GO:0033108)3.24450992
35regulation of nuclear cell cycle DNA replication (GO:0033262)3.19610204
36cornea development in camera-type eye (GO:0061303)3.15465449
37kynurenine metabolic process (GO:0070189)3.13353153
38mannosylation (GO:0097502)3.11701807
39peptidyl-histidine modification (GO:0018202)3.09776450
40rRNA catabolic process (GO:0016075)3.08640812
41indolalkylamine metabolic process (GO:0006586)3.08638079
42reciprocal DNA recombination (GO:0035825)3.08518879
43reciprocal meiotic recombination (GO:0007131)3.08518879
44pseudouridine synthesis (GO:0001522)3.07655782
45estrogen biosynthetic process (GO:0006703)3.05288351
46protein-cofactor linkage (GO:0018065)3.01454205
47ketone body metabolic process (GO:1902224)3.01271185
48regulation of heat generation (GO:0031650)3.00544151
49cilium or flagellum-dependent cell motility (GO:0001539)2.99535927
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98982877
51water-soluble vitamin biosynthetic process (GO:0042364)2.98973691
52platelet dense granule organization (GO:0060155)2.98780326
53DNA strand renaturation (GO:0000733)2.96580773
54GPI anchor metabolic process (GO:0006505)2.88537913
55negative regulation of telomerase activity (GO:0051974)2.86237734
56DNA methylation involved in gamete generation (GO:0043046)2.85125713
57positive regulation of defense response to virus by host (GO:0002230)2.84163292
58multicellular organism reproduction (GO:0032504)2.83582312
59tryptophan metabolic process (GO:0006568)2.82757093
60protein import into peroxisome matrix (GO:0016558)2.80236664
61regulation of synapse structural plasticity (GO:0051823)2.79621713
62protein polyglutamylation (GO:0018095)2.77070218
63cilium movement (GO:0003341)2.76507799
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74425491
65sulfation (GO:0051923)2.73215789
66maturation of 5.8S rRNA (GO:0000460)2.72455303
67C-terminal protein lipidation (GO:0006501)2.71557418
68regulation of skeletal muscle contraction (GO:0014819)2.66085162
69cilium morphogenesis (GO:0060271)2.65752992
70replication fork processing (GO:0031297)2.64744701
71RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64417986
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63034439
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62205970
74tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62205970
75positive regulation of prostaglandin secretion (GO:0032308)2.61071206
76exogenous drug catabolic process (GO:0042738)2.60193873
77synaptic transmission, cholinergic (GO:0007271)2.59995095
78protein localization to cilium (GO:0061512)2.59347901
79spinal cord motor neuron differentiation (GO:0021522)2.59239136
80purinergic nucleotide receptor signaling pathway (GO:0035590)2.56712202
81C-terminal protein amino acid modification (GO:0018410)2.56314888
82cellular biogenic amine catabolic process (GO:0042402)2.54262824
83amine catabolic process (GO:0009310)2.54262824
84neuronal action potential (GO:0019228)2.54180062
85tRNA modification (GO:0006400)2.52080206
86purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.50851944
873-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.50851944
88glycerophospholipid catabolic process (GO:0046475)2.48932917
89photoreceptor cell development (GO:0042461)2.48858059
90regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48781745
91GPI anchor biosynthetic process (GO:0006506)2.45812407
92fucosylation (GO:0036065)2.45242408
93tRNA processing (GO:0008033)2.44618745
94recombinational repair (GO:0000725)2.43245157
95negative regulation of reactive oxygen species metabolic process (GO:2000378)2.42780591
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.42559227
97double-strand break repair via homologous recombination (GO:0000724)2.41867367
98positive regulation of fatty acid transport (GO:2000193)2.40488668
99negative regulation of mast cell activation (GO:0033004)2.40289265
100regulation of action potential (GO:0098900)2.40033696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.55807739
2HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78241462
3VDR_22108803_ChIP-Seq_LS180_Human2.47444785
4EWS_26573619_Chip-Seq_HEK293_Human2.45855794
5NOTCH1_21737748_ChIP-Seq_TLL_Human2.45345746
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.38081593
7FUS_26573619_Chip-Seq_HEK293_Human2.27591139
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24150482
9GBX2_23144817_ChIP-Seq_PC3_Human2.20760682
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18978721
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.14396923
12TP53_22573176_ChIP-Seq_HFKS_Human2.08169667
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98121453
14IGF1R_20145208_ChIP-Seq_DFB_Human1.95439438
15SALL1_21062744_ChIP-ChIP_HESCs_Human1.94861860
16TAF15_26573619_Chip-Seq_HEK293_Human1.91427726
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84916971
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.84888807
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81758812
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80583716
21ER_23166858_ChIP-Seq_MCF-7_Human1.76212580
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75735820
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74036606
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73045198
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.72326485
26EZH2_22144423_ChIP-Seq_EOC_Human1.69963742
27IRF1_19129219_ChIP-ChIP_H3396_Human1.64979064
28ERA_21632823_ChIP-Seq_H3396_Human1.63956915
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57049735
30VDR_23849224_ChIP-Seq_CD4+_Human1.52851629
31NCOR_22424771_ChIP-Seq_293T_Human1.50590057
32MYC_18940864_ChIP-ChIP_HL60_Human1.50586485
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48337625
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47395914
35ETV2_25802403_ChIP-Seq_MESCs_Mouse1.46897052
36CBP_20019798_ChIP-Seq_JUKART_Human1.45332597
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45332597
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45086992
39MYC_19829295_ChIP-Seq_ESCs_Human1.44446989
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.44333535
41P300_19829295_ChIP-Seq_ESCs_Human1.43772593
42FOXA1_25329375_ChIP-Seq_VCAP_Human1.43150724
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43150724
44P53_21459846_ChIP-Seq_SAOS-2_Human1.41672633
45NANOG_20526341_ChIP-Seq_ESCs_Human1.41167457
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.40978068
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40016296
48REST_21632747_ChIP-Seq_MESCs_Mouse1.38781155
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.38265322
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36678873
51E2F1_20622854_ChIP-Seq_HELA_Human1.35831666
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33779824
53HOXB7_26014856_ChIP-Seq_BT474_Human1.31370027
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.30067449
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28646207
56TAF2_19829295_ChIP-Seq_ESCs_Human1.26485068
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.26207940
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26189774
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25509266
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25493993
61BCAT_22108803_ChIP-Seq_LS180_Human1.25138712
62AR_20517297_ChIP-Seq_VCAP_Human1.24848009
63OCT4_20526341_ChIP-Seq_ESCs_Human1.23629161
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22497589
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.22253804
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20461469
67SOX2_19829295_ChIP-Seq_ESCs_Human1.18826575
68NANOG_19829295_ChIP-Seq_ESCs_Human1.18826575
69STAT3_23295773_ChIP-Seq_U87_Human1.17695644
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16620882
71AR_25329375_ChIP-Seq_VCAP_Human1.16578710
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14592920
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14592920
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13852941
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13269129
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12040203
77TCF4_23295773_ChIP-Seq_U87_Human1.11832473
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.08938655
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08818537
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07883782
81FOXP3_21729870_ChIP-Seq_TREG_Human1.07775724
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07365970
83TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06882419
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06866370
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06284544
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05140701
87PHF8_20622854_ChIP-Seq_HELA_Human1.05065936
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.04898300
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04402210
90FOXH1_21741376_ChIP-Seq_EPCs_Human1.03933954
91TCF4_22108803_ChIP-Seq_LS180_Human1.03794881
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03154223
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02195131
94RAC3_21632823_ChIP-Seq_H3396_Human1.02183274
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01402311
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01363169
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00192814
98AR_21572438_ChIP-Seq_LNCaP_Human0.99730105
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98464616
100GATA3_26560356_Chip-Seq_TH2_Human0.98324819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok3.44372060
2MP0005174_abnormal_tail_pigmentation3.35338086
3MP0001986_abnormal_taste_sensitivity3.18351846
4MP0005171_absent_coat_pigmentation2.79068231
5MP0005551_abnormal_eye_electrophysiolog2.66372294
6MP0001968_abnormal_touch/_nociception2.64108245
7MP0003195_calcinosis2.50184061
8MP0002102_abnormal_ear_morphology2.44344468
9MP0003136_yellow_coat_color2.39279338
10MP0008877_abnormal_DNA_methylation2.35775757
11MP0004147_increased_porphyrin_level2.17839171
12MP0002736_abnormal_nociception_after2.02639448
13MP0004043_abnormal_pH_regulation2.01377281
14MP0002163_abnormal_gland_morphology1.97730425
15MP0005423_abnormal_somatic_nervous1.95760181
16MP0003880_abnormal_central_pattern1.95659531
17MP0002876_abnormal_thyroid_physiology1.92765868
18MP0005253_abnormal_eye_physiology1.91626905
19MP0006292_abnormal_olfactory_placode1.84643726
20MP0008872_abnormal_physiological_respon1.83715548
21MP0002837_dystrophic_cardiac_calcinosis1.77083524
22MP0009745_abnormal_behavioral_response1.74943419
23MP0001919_abnormal_reproductive_system1.74821316
24MP0003787_abnormal_imprinting1.73707771
25MP0002254_reproductive_system_inflammat1.72760600
26MP0000372_irregular_coat_pigmentation1.71089457
27MP0006072_abnormal_retinal_apoptosis1.70905020
28MP0002638_abnormal_pupillary_reflex1.67650590
29MP0002735_abnormal_chemical_nociception1.63951508
30MP0002160_abnormal_reproductive_system1.61986525
31MP0000569_abnormal_digit_pigmentation1.59599279
32MP0005075_abnormal_melanosome_morpholog1.56168232
33MP0004133_heterotaxia1.55549189
34MP0003646_muscle_fatigue1.54441277
35MP0005410_abnormal_fertilization1.54219795
36MP0009046_muscle_twitch1.51626124
37MP0000427_abnormal_hair_cycle1.50555418
38MP0006276_abnormal_autonomic_nervous1.47724461
39MP0005389_reproductive_system_phenotype1.47296338
40MP0000015_abnormal_ear_pigmentation1.46965501
41MP0005084_abnormal_gallbladder_morpholo1.43137876
42MP0002938_white_spotting1.39393236
43MP0005379_endocrine/exocrine_gland_phen1.38890015
44MP0004885_abnormal_endolymph1.37503874
45MP0000631_abnormal_neuroendocrine_gland1.32824672
46MP0000538_abnormal_urinary_bladder1.32729747
47MP0005332_abnormal_amino_acid1.31905473
48MP0005646_abnormal_pituitary_gland1.31819888
49MP0001502_abnormal_circadian_rhythm1.31781406
50MP0001529_abnormal_vocalization1.31653843
51MP0001970_abnormal_pain_threshold1.28462530
52MP0003806_abnormal_nucleotide_metabolis1.27570401
53MP0002272_abnormal_nervous_system1.25604855
54MP0004142_abnormal_muscle_tone1.24321864
55MP0005645_abnormal_hypothalamus_physiol1.19369743
56MP0002733_abnormal_thermal_nociception1.13494163
57MP0001324_abnormal_eye_pigmentation1.12354333
58MP0008775_abnormal_heart_ventricle1.11095696
59MP0002064_seizures1.10211536
60MP0005195_abnormal_posterior_eye1.07981198
61MP0001661_extended_life_span1.05589523
62MP0002095_abnormal_skin_pigmentation1.05310156
63MP0004924_abnormal_behavior1.04362977
64MP0005386_behavior/neurological_phenoty1.04362977
65MP0001756_abnormal_urination1.03471768
66MP0005083_abnormal_biliary_tract1.02470169
67MP0008058_abnormal_DNA_repair0.99746046
68MP0002928_abnormal_bile_duct0.98916265
69MP0001485_abnormal_pinna_reflex0.98366375
70MP0002572_abnormal_emotion/affect_behav0.97736294
71MP0002557_abnormal_social/conspecific_i0.96745461
72MP0005167_abnormal_blood-brain_barrier0.95064847
73MP0002653_abnormal_ependyma_morphology0.93000568
74MP0002751_abnormal_autonomic_nervous0.89888048
75MP0001486_abnormal_startle_reflex0.89829095
76MP0001501_abnormal_sleep_pattern0.89706236
77MP0000470_abnormal_stomach_morphology0.87466549
78MP0000647_abnormal_sebaceous_gland0.86942619
79MP0003635_abnormal_synaptic_transmissio0.86940018
80MP0001764_abnormal_homeostasis0.86223049
81MP0003718_maternal_effect0.85804209
82MP0001963_abnormal_hearing_physiology0.84270542
83MP0001188_hyperpigmentation0.83679459
84MP0001905_abnormal_dopamine_level0.83474607
85MP0002210_abnormal_sex_determination0.82982119
86MP0003698_abnormal_male_reproductive0.82257790
87MP0008995_early_reproductive_senescence0.79914483
88MP0004742_abnormal_vestibular_system0.79487393
89MP0005365_abnormal_bile_salt0.78654687
90MP0002063_abnormal_learning/memory/cond0.77973444
91MP0002234_abnormal_pharynx_morphology0.77702896
92MP0003011_delayed_dark_adaptation0.77583540
93MP0005671_abnormal_response_to0.76747084
94MP0003137_abnormal_impulse_conducting0.76604923
95MP0002734_abnormal_mechanical_nocicepti0.75669450
96MP0002067_abnormal_sensory_capabilities0.75184825
97MP0000230_abnormal_systemic_arterial0.75061002
98MP0002909_abnormal_adrenal_gland0.74794095
99MP0001929_abnormal_gametogenesis0.74442084
100MP0004215_abnormal_myocardial_fiber0.74000952

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.61639215
2Attenuation of retinal blood vessels (HP:0007843)4.48248889
3Abnormality of midbrain morphology (HP:0002418)3.92284207
4Molar tooth sign on MRI (HP:0002419)3.92284207
5Pancreatic cysts (HP:0001737)3.77152296
6Chronic hepatic failure (HP:0100626)3.55669447
7Lipid accumulation in hepatocytes (HP:0006561)3.53064773
8Increased hepatocellular lipid droplets (HP:0006565)3.48670286
9Decreased electroretinogram (ERG) amplitude (HP:0000654)3.45506656
10Nephronophthisis (HP:0000090)3.43615230
11Pancreatic fibrosis (HP:0100732)3.41273483
12Rib fusion (HP:0000902)3.40912236
13Hyperventilation (HP:0002883)3.35734224
14Mesangial abnormality (HP:0001966)3.27887077
15Decreased central vision (HP:0007663)3.27331665
16True hermaphroditism (HP:0010459)3.26340285
17Polydipsia (HP:0001959)3.21824858
18Abnormal drinking behavior (HP:0030082)3.21824858
19Renal Fanconi syndrome (HP:0001994)3.08494197
20Type II lissencephaly (HP:0007260)3.06887227
21Testicular atrophy (HP:0000029)2.99504611
22Abnormality of the renal medulla (HP:0100957)2.93876835
23Bony spicule pigmentary retinopathy (HP:0007737)2.88669519
24Mitochondrial inheritance (HP:0001427)2.82353454
25Increased CSF lactate (HP:0002490)2.79237550
26Abnormal rod and cone electroretinograms (HP:0008323)2.78729703
27Dyschromatopsia (HP:0007641)2.78382921
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76386614
29Pendular nystagmus (HP:0012043)2.75353860
30Abnormality of the renal cortex (HP:0011035)2.62987693
31Tubular atrophy (HP:0000092)2.61166417
32Abolished electroretinogram (ERG) (HP:0000550)2.59464299
33Patellar aplasia (HP:0006443)2.55849552
34Polyuria (HP:0000103)2.55514024
35Chorioretinal atrophy (HP:0000533)2.53290883
36Hepatocellular necrosis (HP:0001404)2.51519601
37Aplasia/Hypoplasia of the patella (HP:0006498)2.43684969
38Cerebellar dysplasia (HP:0007033)2.40104824
39Exertional dyspnea (HP:0002875)2.31768917
40Hypoalbuminemia (HP:0003073)2.29774783
41Abnormal albumin level (HP:0012116)2.29774783
42Inability to walk (HP:0002540)2.25455188
43Cystic liver disease (HP:0006706)2.25143206
44Optic disc pallor (HP:0000543)2.20507564
45Medial flaring of the eyebrow (HP:0010747)2.17716597
46Abnormality of alanine metabolism (HP:0010916)2.17448270
47Hyperalaninemia (HP:0003348)2.17448270
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17448270
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.15589388
50Decreased circulating renin level (HP:0003351)2.13147088
51Increased intramyocellular lipid droplets (HP:0012240)2.12801219
52Abnormality of the pons (HP:0007361)2.12145157
53Hepatic necrosis (HP:0002605)2.11591356
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10053086
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.09869776
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09840219
57Increased serum lactate (HP:0002151)2.08979268
58Progressive inability to walk (HP:0002505)2.07746739
59Lissencephaly (HP:0001339)2.04189363
60Abnormal urine output (HP:0012590)2.02690791
61Rectal fistula (HP:0100590)2.02489181
62Rectovaginal fistula (HP:0000143)2.02489181
63Gaze-evoked nystagmus (HP:0000640)1.97005317
64Hypoplasia of the fovea (HP:0007750)1.96081765
65Aplasia/Hypoplasia of the fovea (HP:0008060)1.96081765
66Hypoplasia of the pons (HP:0012110)1.95333261
67Facial diplegia (HP:0001349)1.94905167
68Increased muscle lipid content (HP:0009058)1.91938979
69Absent speech (HP:0001344)1.90518300
70Methylmalonic aciduria (HP:0012120)1.90406027
71Absent thumb (HP:0009777)1.89570445
72Abnormal biliary tract physiology (HP:0012439)1.89292873
73Bile duct proliferation (HP:0001408)1.89292873
74Congenital hepatic fibrosis (HP:0002612)1.89073557
753-Methylglutaconic aciduria (HP:0003535)1.88534931
76Poikiloderma (HP:0001029)1.85704531
77Severe muscular hypotonia (HP:0006829)1.84301332
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.83085289
79Abnormality of renal resorption (HP:0011038)1.82986049
80Large for gestational age (HP:0001520)1.81967663
81Acute necrotizing encephalopathy (HP:0006965)1.80811450
82Severe visual impairment (HP:0001141)1.79387579
83Type 2 muscle fiber atrophy (HP:0003554)1.78084724
84Respiratory difficulties (HP:0002880)1.76990659
85Squamous cell carcinoma (HP:0002860)1.74394338
86Fair hair (HP:0002286)1.73978503
87Glycosuria (HP:0003076)1.73664182
88Abnormality of urine glucose concentration (HP:0011016)1.73664182
89Sclerocornea (HP:0000647)1.70246693
90Small hand (HP:0200055)1.68675846
91Neonatal respiratory distress (HP:0002643)1.68379797
92Clumsiness (HP:0002312)1.67566517
93Hypophosphatemic rickets (HP:0004912)1.66451560
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66431537
95Abnormality of the fovea (HP:0000493)1.66382900
96Abnormality of renal excretion (HP:0011036)1.66350994
97Anencephaly (HP:0002323)1.66257281
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.66008767
99Stomach cancer (HP:0012126)1.65828063
100Aplasia/hypoplasia of the uterus (HP:0008684)1.65442993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.57306313
2MAP4K24.40684973
3TLK14.23755823
4WNK43.75552186
5ADRBK23.06966488
6MAPK152.98546816
7MAP2K62.82528280
8BMPR1B2.65518799
9ZAK2.30323569
10NUAK12.26460648
11ACVR1B2.15088832
12WNK32.11297447
13TAOK22.07938776
14TAOK32.07347344
15GRK11.84552725
16STK391.78224156
17SIK21.76791121
18MUSK1.76775398
19CASK1.75142060
20PINK11.75054545
21OXSR11.74665135
22TRIM281.64023759
23DAPK21.63586082
24MAPK131.50188977
25TXK1.45059024
26ADRBK11.31188159
27MAP3K41.21178062
28MKNK21.08689228
29BCKDK1.07530966
30TGFBR10.95822857
31INSRR0.95125611
32PRKCI0.91490901
33BCR0.86387659
34MARK10.86364649
35MST40.84587026
36FGFR20.84234928
37CSNK1G10.81261509
38PAK30.80530470
39CSNK1G30.79685495
40TNIK0.79272882
41PHKG20.76563093
42PHKG10.76563093
43IKBKB0.74335669
44MAPKAPK30.73541351
45NME10.72997988
46KIT0.69801904
47DYRK20.68571438
48PIK3CA0.67397462
49CSNK1A1L0.67149184
50CSNK1G20.66615544
51PTK2B0.66420422
52PRKCG0.65016802
53PRKCE0.64506250
54TIE10.61592203
55EIF2AK30.60964812
56STK30.59929244
57CAMKK20.59396079
58MAP2K70.58202862
59STK110.58012729
60NEK20.57964701
61AKT30.56095037
62MAPKAPK50.52879154
63VRK20.49869669
64CSNK1D0.47241813
65DYRK30.47162965
66IRAK10.46913549
67PRKCQ0.46428794
68ERBB30.45189487
69NTRK30.45123602
70GRK60.45027794
71VRK10.44513929
72PDK20.42805863
73RPS6KA50.42705831
74MAP3K50.42634213
75CSNK1A10.42399726
76PLK20.41517744
77MKNK10.39117000
78PRKAA10.38483765
79TEC0.36561352
80NLK0.36097946
81ATR0.36018177
82TAF10.35295359
83GRK50.33930412
84CHEK20.33859157
85PRKCZ0.33546509
86EPHA40.32497677
87MARK30.30451347
88PRKACA0.30330586
89SYK0.29844366
90ITK0.29507155
91TSSK60.29083936
92SIK30.28975187
93CAMK2A0.28952281
94PLK40.28029212
95CAMK10.27368130
96PRKCA0.27049187
97IKBKE0.26464032
98CAMK1D0.26049357
99PKN10.25080017
100CHUK0.24323007

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.19709405
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.26586009
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.11558290
4Phototransduction_Homo sapiens_hsa047442.81872440
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.54795166
6Nitrogen metabolism_Homo sapiens_hsa009102.47172514
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25441365
8Oxidative phosphorylation_Homo sapiens_hsa001902.25370818
9Linoleic acid metabolism_Homo sapiens_hsa005912.11142616
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06903505
11RNA polymerase_Homo sapiens_hsa030201.99166004
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96085897
13Basal transcription factors_Homo sapiens_hsa030221.89595192
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85660702
15Caffeine metabolism_Homo sapiens_hsa002321.85449695
16Nicotine addiction_Homo sapiens_hsa050331.75162634
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73674596
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72117091
19Butanoate metabolism_Homo sapiens_hsa006501.69423084
20Fanconi anemia pathway_Homo sapiens_hsa034601.64129694
21Sulfur relay system_Homo sapiens_hsa041221.63234463
22Parkinsons disease_Homo sapiens_hsa050121.57105644
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54856236
24Selenocompound metabolism_Homo sapiens_hsa004501.53976452
25Homologous recombination_Homo sapiens_hsa034401.52086350
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.48398888
27Ether lipid metabolism_Homo sapiens_hsa005651.44325474
28Protein export_Homo sapiens_hsa030601.41551741
29RNA degradation_Homo sapiens_hsa030181.37233651
30Taste transduction_Homo sapiens_hsa047421.33540058
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.28578015
32Tryptophan metabolism_Homo sapiens_hsa003801.25525867
33One carbon pool by folate_Homo sapiens_hsa006701.21645169
34Peroxisome_Homo sapiens_hsa041461.20310515
35Olfactory transduction_Homo sapiens_hsa047401.17169676
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14012453
37Huntingtons disease_Homo sapiens_hsa050161.12434597
38Primary immunodeficiency_Homo sapiens_hsa053401.09667717
39Chemical carcinogenesis_Homo sapiens_hsa052041.07872465
40Morphine addiction_Homo sapiens_hsa050321.05597628
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04044891
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03680949
43Alzheimers disease_Homo sapiens_hsa050100.99940132
44Circadian rhythm_Homo sapiens_hsa047100.98693041
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97928307
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.92302573
47Propanoate metabolism_Homo sapiens_hsa006400.91413061
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.90139866
49Ovarian steroidogenesis_Homo sapiens_hsa049130.89938821
50Sphingolipid metabolism_Homo sapiens_hsa006000.85319401
51Regulation of autophagy_Homo sapiens_hsa041400.82663623
52Purine metabolism_Homo sapiens_hsa002300.80462506
53Cardiac muscle contraction_Homo sapiens_hsa042600.79188488
54Collecting duct acid secretion_Homo sapiens_hsa049660.77797473
55Pyrimidine metabolism_Homo sapiens_hsa002400.75290596
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.74565633
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74340090
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74189565
59GABAergic synapse_Homo sapiens_hsa047270.73801689
60Arachidonic acid metabolism_Homo sapiens_hsa005900.72812582
61Retinol metabolism_Homo sapiens_hsa008300.70170056
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68572552
63Metabolic pathways_Homo sapiens_hsa011000.68297302
64ABC transporters_Homo sapiens_hsa020100.68166148
65Hedgehog signaling pathway_Homo sapiens_hsa043400.62283687
66Glutamatergic synapse_Homo sapiens_hsa047240.62214709
67Sulfur metabolism_Homo sapiens_hsa009200.62012304
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61627850
69Asthma_Homo sapiens_hsa053100.61237729
70Circadian entrainment_Homo sapiens_hsa047130.60824152
71Glycerolipid metabolism_Homo sapiens_hsa005610.60740134
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60605286
73Proteasome_Homo sapiens_hsa030500.60125333
74Insulin secretion_Homo sapiens_hsa049110.59871348
75Cocaine addiction_Homo sapiens_hsa050300.59586837
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57234555
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56942424
78Salivary secretion_Homo sapiens_hsa049700.55473893
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55417191
80Steroid biosynthesis_Homo sapiens_hsa001000.54010486
81Serotonergic synapse_Homo sapiens_hsa047260.53604036
82Calcium signaling pathway_Homo sapiens_hsa040200.51928496
83Vitamin digestion and absorption_Homo sapiens_hsa049770.51763357
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.51416574
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51332955
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48153722
87Dorso-ventral axis formation_Homo sapiens_hsa043200.46314287
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44843623
89Type I diabetes mellitus_Homo sapiens_hsa049400.39496861
90Nucleotide excision repair_Homo sapiens_hsa034200.39229538
91beta-Alanine metabolism_Homo sapiens_hsa004100.37310632
92Mineral absorption_Homo sapiens_hsa049780.35565513
93Fat digestion and absorption_Homo sapiens_hsa049750.35561217
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34244913
95Non-homologous end-joining_Homo sapiens_hsa034500.33044263
96Basal cell carcinoma_Homo sapiens_hsa052170.32870483
97Glutathione metabolism_Homo sapiens_hsa004800.29298652
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.29087206
99Rheumatoid arthritis_Homo sapiens_hsa053230.24646107
100Allograft rejection_Homo sapiens_hsa053300.23387936

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