PANX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.02930159
2hemidesmosome assembly (GO:0031581)5.44860040
3nucleobase catabolic process (GO:0046113)5.42544623
4cell adhesion mediated by integrin (GO:0033627)5.42108765
5negative regulation of microtubule polymerization (GO:0031115)5.04579545
6regulation of vitamin D biosynthetic process (GO:0060556)4.97822437
7regulation of mononuclear cell migration (GO:0071675)4.34170719
8Golgi transport vesicle coating (GO:0048200)4.30072194
9COPI coating of Golgi vesicle (GO:0048205)4.30072194
10protein localization to endosome (GO:0036010)4.14751451
11skin morphogenesis (GO:0043589)4.01314465
12viral transcription (GO:0019083)3.97543757
13translational termination (GO:0006415)3.78657299
14negative regulation of cell killing (GO:0031342)3.76039497
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.76039497
16regulation of NFAT protein import into nucleus (GO:0051532)3.70577136
17peptidyl-arginine omega-N-methylation (GO:0035247)3.66670704
18substrate-dependent cell migration (GO:0006929)3.65533245
19regulation of vitamin metabolic process (GO:0030656)3.59111340
20central nervous system projection neuron axonogenesis (GO:0021952)3.57064401
21positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.53978413
22regulation of fever generation (GO:0031620)3.52697930
23protein-DNA complex disassembly (GO:0032986)3.52315854
24nucleosome disassembly (GO:0006337)3.52315854
25negative regulation of RNA splicing (GO:0033119)3.43615675
26cell-substrate junction assembly (GO:0007044)3.42947683
27regulation of T-helper 1 cell differentiation (GO:0045625)3.40154496
28Arp2/3 complex-mediated actin nucleation (GO:0034314)3.39760929
29regulation of membrane protein ectodomain proteolysis (GO:0051043)3.38846768
30paraxial mesoderm development (GO:0048339)3.36048630
31negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.33644238
32urogenital system development (GO:0001655)3.31595310
33peptidyl-arginine N-methylation (GO:0035246)3.30607100
34peptidyl-arginine methylation (GO:0018216)3.30607100
35sequestering of actin monomers (GO:0042989)3.29197596
36heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.29177353
37regulation of isotype switching to IgG isotypes (GO:0048302)3.28622573
38cell migration in hindbrain (GO:0021535)3.24094686
39regulation of cytokine secretion involved in immune response (GO:0002739)3.24063778
40ribosomal small subunit assembly (GO:0000028)3.22478274
41cellular protein complex disassembly (GO:0043624)3.22351922
42branching involved in labyrinthine layer morphogenesis (GO:0060670)3.22053342
43protein complex disassembly (GO:0043241)3.21313386
44regulation of chronic inflammatory response (GO:0002676)3.19696143
45cranial nerve morphogenesis (GO:0021602)3.17630488
46positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.17516263
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17157201
48stress fiber assembly (GO:0043149)3.14765030
49viral life cycle (GO:0019058)3.13678474
50translational elongation (GO:0006414)3.13063477
51dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.12075800
52dosage compensation (GO:0007549)3.10315132
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10310063
54dendritic spine morphogenesis (GO:0060997)3.08647848
55positive regulation of endothelial cell apoptotic process (GO:2000353)3.06485349
56macromolecular complex disassembly (GO:0032984)3.05055835
57ganglion development (GO:0061548)3.02291937
58axonal fasciculation (GO:0007413)3.01539469
59DNA unwinding involved in DNA replication (GO:0006268)2.99607832
60eosinophil chemotaxis (GO:0048245)2.97712304
61endodermal cell differentiation (GO:0035987)2.97304962
62positive regulation of heat generation (GO:0031652)2.97215945
63positive regulation of chemokine biosynthetic process (GO:0045080)2.97136036
64response to pheromone (GO:0019236)2.96926368
65neuron cell-cell adhesion (GO:0007158)2.96327459
66cellular response to interleukin-15 (GO:0071350)2.94151755
67regulation of protein heterodimerization activity (GO:0043497)2.93705877
68sarcoplasmic reticulum calcium ion transport (GO:0070296)2.89569563
69cellular response to interferon-alpha (GO:0035457)2.89565543
70neuron recognition (GO:0008038)2.88951020
71mesodermal cell differentiation (GO:0048333)2.86674789
72histone arginine methylation (GO:0034969)2.86568962
73negative regulation of oligodendrocyte differentiation (GO:0048715)2.85782796
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85347004
75regulation of podosome assembly (GO:0071801)2.84399594
76negative regulation of axon guidance (GO:1902668)2.83314465
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81702831
78epithelial cell-cell adhesion (GO:0090136)2.80145374
79hippocampus development (GO:0021766)2.79808455
80decidualization (GO:0046697)2.77646099
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77624196
82regulation of chemokine biosynthetic process (GO:0045073)2.77222537
83translational initiation (GO:0006413)2.77213264
84generation of neurons (GO:0048699)2.75698006
85positive regulation of p38MAPK cascade (GO:1900745)2.75692558
86cotranslational protein targeting to membrane (GO:0006613)2.74196677
87regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.73168252
88positive thymic T cell selection (GO:0045059)2.72436424
89protein targeting to ER (GO:0045047)2.72403238
90regulation of defense response to virus by virus (GO:0050690)2.72206124
91adhesion of symbiont to host cell (GO:0044650)2.71258443
92virion attachment to host cell (GO:0019062)2.71258443
93forebrain neuron differentiation (GO:0021879)2.70632708
94chronic inflammatory response (GO:0002544)2.70209347
95activated T cell proliferation (GO:0050798)2.67862480
96regulation of immunoglobulin secretion (GO:0051023)2.67639310
97negative T cell selection (GO:0043383)2.67353622
98layer formation in cerebral cortex (GO:0021819)2.66374599
99positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.65756917
100regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.65756917
101regulation of early endosome to late endosome transport (GO:2000641)2.65580869
102negative regulation of axon extension involved in axon guidance (GO:0048843)2.65576895
103positive regulation of filopodium assembly (GO:0051491)2.65225697
104lymphoid progenitor cell differentiation (GO:0002320)2.64797645
105maturation of SSU-rRNA (GO:0030490)2.64320146
106chaperone-mediated protein transport (GO:0072321)2.62909911
107auditory behavior (GO:0031223)2.62616202
108ribosomal small subunit biogenesis (GO:0042274)2.62254481
109monocyte chemotaxis (GO:0002548)2.61963642
110negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.60844548
111positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.60824441
112actin nucleation (GO:0045010)2.60527965
113endocytic recycling (GO:0032456)2.59785752
114retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59785039
115regulation of ruffle assembly (GO:1900027)2.59509937
116activation of MAPKKK activity (GO:0000185)2.59459030
117regulation of transforming growth factor beta2 production (GO:0032909)2.59435687
118positive T cell selection (GO:0043368)2.59329309
119regulation of sister chromatid cohesion (GO:0007063)2.58621223
120regulation of synapse structural plasticity (GO:0051823)2.58585064
121eosinophil migration (GO:0072677)2.58139317
122establishment of protein localization to endoplasmic reticulum (GO:0072599)2.57059523
123negative thymic T cell selection (GO:0045060)2.57031626
124neurofilament cytoskeleton organization (GO:0060052)2.56441673
125glial cell migration (GO:0008347)2.55959109
126protein localization to endoplasmic reticulum (GO:0070972)2.54240574
127fibrinolysis (GO:0042730)2.53722678
128adhesion of symbiont to host (GO:0044406)2.53721898
129linoleic acid metabolic process (GO:0043651)2.52706787
130response to interleukin-15 (GO:0070672)2.50838894
131negative regulation of lipid storage (GO:0010888)2.50717232
132regulation of nitric oxide biosynthetic process (GO:0045428)2.50639000
133maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.50511098
134COPII vesicle coating (GO:0048208)2.50400371
135branching involved in mammary gland duct morphogenesis (GO:0060444)2.50380089
136negative regulation of mRNA processing (GO:0050686)2.50360733
137positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.48357066
138positive regulation of nitric oxide biosynthetic process (GO:0045429)2.48331633
139positive regulation of hair follicle development (GO:0051798)2.48236235
140positive regulation of hair cycle (GO:0042635)2.48236235
141regulation of microtubule polymerization (GO:0031113)2.48077356
142behavioral response to nicotine (GO:0035095)2.47746688
143regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.47512561
144axon extension involved in axon guidance (GO:0048846)2.46181698
145neuron projection extension involved in neuron projection guidance (GO:1902284)2.46181698
146regulation of integrin activation (GO:0033623)2.44977695
147negative regulation of anoikis (GO:2000811)2.44278506
148central nervous system neuron axonogenesis (GO:0021955)2.44067678
149T cell receptor signaling pathway (GO:0050852)2.43470990
150response to vitamin D (GO:0033280)2.43455598
151pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.42848652
152regulation of T-helper 2 cell differentiation (GO:0045628)2.42491148
153vesicle fusion (GO:0006906)2.42393521
154spinal cord association neuron differentiation (GO:0021527)2.42060480
155mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.41379551
156barbed-end actin filament capping (GO:0051016)2.40375858
157positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.40167260
158positive regulation of synapse assembly (GO:0051965)2.39610895
159negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.39540213
160dopaminergic neuron differentiation (GO:0071542)2.38111158
161positive regulation of interleukin-6 production (GO:0032755)2.37933824
162regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.37672374
163neuron migration (GO:0001764)2.36820473
164localization within membrane (GO:0051668)2.36597216
165adherens junction assembly (GO:0034333)2.36251100
166hippo signaling (GO:0035329)2.35907010
167de novo posttranslational protein folding (GO:0051084)2.35899635
168positive regulation of gamma-delta T cell activation (GO:0046645)2.35603561
169thymic T cell selection (GO:0045061)2.35048800
170protein retention in ER lumen (GO:0006621)2.34506328
171wound healing, spreading of epidermal cells (GO:0035313)2.34373981
172histamine secretion (GO:0001821)2.33313390
173regulation of axon extension (GO:0030516)2.32953724
174DNA demethylation (GO:0080111)2.32772878
175regulation of heterotypic cell-cell adhesion (GO:0034114)2.32283623
176regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.31699982
177sphingosine metabolic process (GO:0006670)2.31029694
178lipopolysaccharide-mediated signaling pathway (GO:0031663)2.30732805
179response to auditory stimulus (GO:0010996)2.30059918
180negative regulation of axon extension (GO:0030517)2.29927910
181regulation of chemokine-mediated signaling pathway (GO:0070099)2.29297055
182regulation of hair follicle development (GO:0051797)2.29278015
183cellular response to lipopolysaccharide (GO:0071222)2.28838146
184T cell homeostasis (GO:0043029)2.28552340
185negative regulation of homotypic cell-cell adhesion (GO:0034111)2.28406233
186antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27554080
187antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27554080
188negative regulation of vascular permeability (GO:0043116)2.26816394
189interferon-gamma production (GO:0032609)2.25977867
190antigen receptor-mediated signaling pathway (GO:0050851)2.25855345
191glycosphingolipid catabolic process (GO:0046479)2.25714872
192vesicle coating (GO:0006901)2.24611970
193leukocyte aggregation (GO:0070486)2.24248006
194hypotonic response (GO:0006971)2.24153827
195collagen metabolic process (GO:0032963)2.23095915
196response to laminar fluid shear stress (GO:0034616)2.23064269
197T cell selection (GO:0045058)2.22816249
198response to magnesium ion (GO:0032026)2.21998688
199positive regulation of Rho protein signal transduction (GO:0035025)2.21662472
200regulation of glucose import in response to insulin stimulus (GO:2001273)2.21658449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.71769649
2EZH2_22144423_ChIP-Seq_EOC_Human5.62590731
3E2F7_22180533_ChIP-Seq_HELA_Human4.61274015
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.16361035
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.88610854
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.27745433
7MYC_22102868_ChIP-Seq_BL_Human2.88914349
8CLOCK_20551151_ChIP-Seq_293T_Human2.84894880
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.79477204
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.78463994
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.67306359
12ZNF263_19887448_ChIP-Seq_K562_Human2.66486661
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46093870
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41958178
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.41663272
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.39930267
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.39930267
18* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.39302448
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.35875545
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.35435985
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32742556
22* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29009837
23* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.26236392
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25493628
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23833765
26GATA1_22025678_ChIP-Seq_K562_Human2.21490681
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18001908
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17923148
29VDR_21846776_ChIP-Seq_THP-1_Human2.14596388
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12493257
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.09840521
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09194118
33XRN2_22483619_ChIP-Seq_HELA_Human2.07758982
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.05191558
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.00993313
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.95871969
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94928973
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.93896857
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.92232778
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.92232778
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.92232778
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.85777697
43CIITA_25753668_ChIP-Seq_RAJI_Human1.84940440
44* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.82446857
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78953791
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78905590
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.78601238
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.77461510
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77183521
50TTF2_22483619_ChIP-Seq_HELA_Human1.76777415
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76513063
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75763690
53* UBF1/2_26484160_Chip-Seq_HMECs_Human1.75120854
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73689800
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73113450
56UTX_26944678_Chip-Seq_JUKART_Human1.70114228
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70052230
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69911099
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68226838
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67509474
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67477840
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67186094
63BRD4_25478319_ChIP-Seq_HGPS_Human1.66875026
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.65752045
65CJUN_26792858_Chip-Seq_BT549_Human1.63675102
66SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63666204
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62702462
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.62648444
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60732974
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60382666
71ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.59898057
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59652066
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.59536907
74* MAF_26560356_Chip-Seq_TH1_Human1.58259832
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58186004
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55663813
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.54442265
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52599862
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52599862
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50920963
81KDM2B_26808549_Chip-Seq_DND41_Human1.50856143
82* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50753783
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49910769
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48804973
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.48547554
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48447098
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45357046
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44268931
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42241115
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.40762455
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.40566450
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38035356
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37240073
94MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36196233
95MAF_26560356_Chip-Seq_TH2_Human1.35768345
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35447888
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34707387
98PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34202726
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.33208515
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33062464
101ZNF274_21170338_ChIP-Seq_K562_Hela1.32789248
102* EP300_21415370_ChIP-Seq_HL-1_Mouse1.32096992
103TCF7_22412390_ChIP-Seq_EML_Mouse1.31794285
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31789365
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31162865
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.30917279
107MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30490765
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30299593
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29652785
110RNF2_27304074_Chip-Seq_NSC_Mouse1.29060929
111ESR1_21235772_ChIP-Seq_MCF-7_Human1.29019819
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28762155
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.28278699
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27155152
115MYB_26560356_Chip-Seq_TH2_Human1.25973718
116VDR_24763502_ChIP-Seq_THP-1_Human1.25767352
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23822665
118TP53_16413492_ChIP-PET_HCT116_Human1.23393637
119TP53_18474530_ChIP-ChIP_U2OS_Human1.23352844
120LXR_22292898_ChIP-Seq_THP-1_Human1.22857342
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22042806
122IRF8_21731497_ChIP-ChIP_J774_Mouse1.20955894
123KDM2B_26808549_Chip-Seq_JURKAT_Human1.19953002
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19894370
125DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17829900
126CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16935996
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16317857
128* TFEB_21752829_ChIP-Seq_HELA_Human1.16257650
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15968730
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15578226
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15167592
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15073042
133BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14591844
134ATF3_27146783_Chip-Seq_COLON_Human1.14027959
135RNF2_27304074_Chip-Seq_ESCs_Mouse1.13881213
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13088646
137* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12862536
138REST_18959480_ChIP-ChIP_MESCs_Mouse1.12247226
139REST_21632747_ChIP-Seq_MESCs_Mouse1.12184545
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11784334
141IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11583150
142RING1B_27294783_Chip-Seq_ESCs_Mouse1.11017153
143* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09753185
144VDR_23849224_ChIP-Seq_CD4+_Human1.09739595
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09340305
146THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09165147
147SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08836956
148* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08699089
149TBX20_22080862_ChIP-Seq_HEART_Mouse1.07748600
150TBX20_22328084_ChIP-Seq_HEART_Mouse1.07748600
151ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06943105
152HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06079573
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05573987
154ETS1_20019798_ChIP-Seq_JURKAT_Human1.05334414
155SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05120438
156* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05003115
157JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04803250
158PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04421941
159IGF1R_20145208_ChIP-Seq_DFB_Human1.03341521
160* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02433616
161TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02326856
162GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01828093
163BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01762734
164RUNX_20019798_ChIP-Seq_JUKART_Human1.00790030
165PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00622702
166SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98159950
167* SA1_27219007_Chip-Seq_ERYTHROID_Human0.96752208
168SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96332635
169RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96212601
170SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96146119
171PU_27001747_Chip-Seq_BMDM_Mouse0.94986679
172* TP63_23658742_ChIP-Seq_EP156T_Human0.94129495
173SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93359296
174RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93284705
175MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93025578
176HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92735517
177SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92706480
178DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92620419
179TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92332409
180* TP53_22127205_ChIP-Seq_IMR90_Human0.91696099
181* SOX2_20726797_ChIP-Seq_SW620_Human0.91372144
182CBX2_27304074_Chip-Seq_ESCs_Mouse0.91044367
183GABP_19822575_ChIP-Seq_HepG2_Human0.91001647
184EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90945030
185RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90945030
186CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90561120
187YY1_22570637_ChIP-Seq_MALME-3M_Human0.90171014
188PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89117121
189TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88614050
190NOTCH1_21737748_ChIP-Seq_TLL_Human0.87723943
191CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86537669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006276_abnormal_autonomic_nervous3.62914938
2MP0008438_abnormal_cutaneous_collagen3.61585531
3MP0003705_abnormal_hypodermis_morpholog3.28360318
4MP0004510_myositis3.19979024
5MP0001529_abnormal_vocalization2.99598943
6MP0003566_abnormal_cell_adhesion2.82012543
7MP0003941_abnormal_skin_development2.81687176
8MP0010352_gastrointestinal_tract_polyps2.76283021
9MP0003453_abnormal_keratinocyte_physiol2.72393629
10MP0003763_abnormal_thymus_physiology2.58049126
11MP0003091_abnormal_cell_migration2.50169741
12MP0000778_abnormal_nervous_system2.48523327
13MP0005257_abnormal_intraocular_pressure2.45056819
14MP0004272_abnormal_basement_membrane2.40344458
15MP0008004_abnormal_stomach_pH2.39156190
16MP0003300_gastrointestinal_ulcer2.36379693
17MP0005451_abnormal_body_composition2.35241203
18MP0002332_abnormal_exercise_endurance2.32883660
19MP0003880_abnormal_central_pattern2.29722566
20MP0005275_abnormal_skin_tensile2.26754990
21MP0000569_abnormal_digit_pigmentation2.24185482
22MP0005671_abnormal_response_to2.22533844
23MP0006054_spinal_hemorrhage2.21712499
24MP0005023_abnormal_wound_healing2.20402403
25MP0001968_abnormal_touch/_nociception2.19578545
26MP0004859_abnormal_synaptic_plasticity2.17630966
27MP0005058_abnormal_lysosome_morphology2.14498239
28MP0003122_maternal_imprinting2.07234066
29MP0008961_abnormal_basal_metabolism2.07174104
30MP0002877_abnormal_melanocyte_morpholog2.03783373
31MP0005623_abnormal_meninges_morphology1.98758251
32MP0009840_abnormal_foam_cell1.97551623
33MP0001849_ear_inflammation1.96492594
34MP0002184_abnormal_innervation1.89786884
35MP0000537_abnormal_urethra_morphology1.89195535
36MP0002102_abnormal_ear_morphology1.87283294
37MP0002735_abnormal_chemical_nociception1.87111314
38MP0005423_abnormal_somatic_nervous1.83505326
39MP0006082_CNS_inflammation1.82544382
40MP0002736_abnormal_nociception_after1.78547151
41MP0000579_abnormal_nail_morphology1.78399294
42MP0008789_abnormal_olfactory_epithelium1.75479779
43MP0003315_abnormal_perineum_morphology1.75048932
44MP0003950_abnormal_plasma_membrane1.73549469
45MP0002638_abnormal_pupillary_reflex1.72769084
46MP0002254_reproductive_system_inflammat1.72372623
47MP0002751_abnormal_autonomic_nervous1.68684690
48MP0002733_abnormal_thermal_nociception1.66103200
49MP0000733_abnormal_muscle_development1.62982047
50MP0005174_abnormal_tail_pigmentation1.62496628
51MP0003448_altered_tumor_morphology1.60750917
52MP0002063_abnormal_learning/memory/cond1.58189632
53MP0004947_skin_inflammation1.56858099
54MP0000685_abnormal_immune_system1.53634101
55MP0003221_abnormal_cardiomyocyte_apopto1.53217724
56MP0001835_abnormal_antigen_presentation1.52780667
57MP0000858_altered_metastatic_potential1.51859290
58MP0010030_abnormal_orbit_morphology1.51745963
59MP0001542_abnormal_bone_strength1.51283535
60MP0005076_abnormal_cell_differentiation1.49803080
61MP0003635_abnormal_synaptic_transmissio1.49799532
62MP0002398_abnormal_bone_marrow1.48415077
63MP0000751_myopathy1.48402941
64MP0002557_abnormal_social/conspecific_i1.47680008
65MP0009379_abnormal_foot_pigmentation1.44805993
66MP0004811_abnormal_neuron_physiology1.44120050
67MP0000343_altered_response_to1.43267311
68MP0001915_intracranial_hemorrhage1.42980206
69MP0000703_abnormal_thymus_morphology1.42878937
70MP0005501_abnormal_skin_physiology1.41960457
71MP0005394_taste/olfaction_phenotype1.41848576
72MP0005499_abnormal_olfactory_system1.41848576
73MP0001800_abnormal_humoral_immune1.41402720
74MP0003121_genomic_imprinting1.40900112
75MP0005645_abnormal_hypothalamus_physiol1.40346605
76MP0004233_abnormal_muscle_weight1.39240049
77MP0003279_aneurysm1.35645869
78MP0002420_abnormal_adaptive_immunity1.35149354
79MP0001970_abnormal_pain_threshold1.33762079
80MP0009333_abnormal_splenocyte_physiolog1.33453253
81MP0001873_stomach_inflammation1.33444031
82MP0001819_abnormal_immune_cell1.33240367
83MP0002060_abnormal_skin_morphology1.31473062
84MP0002734_abnormal_mechanical_nocicepti1.31342788
85MP0004270_analgesia1.29185655
86MP0001348_abnormal_lacrimal_gland1.26775905
87MP0001216_abnormal_epidermal_layer1.26518072
88MP0000490_abnormal_crypts_of1.26102171
89MP0005000_abnormal_immune_tolerance1.25558784
90MP0008995_early_reproductive_senescence1.25093261
91MP0000750_abnormal_muscle_regeneration1.23324655
92MP0005464_abnormal_platelet_physiology1.22509222
93MP0009785_altered_susceptibility_to1.22175755
94MP0010234_abnormal_vibrissa_follicle1.21441757
95MP0003861_abnormal_nervous_system1.21198725
96MP0002796_impaired_skin_barrier1.19995232
97MP0010368_abnormal_lymphatic_system1.19829080
98MP0000467_abnormal_esophagus_morphology1.18311129
99MP0000716_abnormal_immune_system1.17820086
100MP0003303_peritoneal_inflammation1.17136145
101MP0002896_abnormal_bone_mineralization1.16595346
102MP0002452_abnormal_antigen_presenting1.16332922
103MP0002723_abnormal_immune_serum1.15387331
104MP0000631_abnormal_neuroendocrine_gland1.14930913
105MP0010678_abnormal_skin_adnexa1.14060077
106MP0002998_abnormal_bone_remodeling1.13529356
107MP0003329_amyloid_beta_deposits1.12475850
108MP0002095_abnormal_skin_pigmentation1.12172679
109MP0001440_abnormal_grooming_behavior1.11559603
110MP0002572_abnormal_emotion/affect_behav1.10045961
111MP0005197_abnormal_uvea_morphology1.08716383
112MP0009764_decreased_sensitivity_to1.07707329
113MP0003866_abnormal_defecation1.07635940
114MP0003890_abnormal_embryonic-extraembry1.06384506
115MP0003724_increased_susceptibility_to1.06294669
116MP0000955_abnormal_spinal_cord1.05054906
117MP0002722_abnormal_immune_system1.04920564
118MP0005025_abnormal_response_to1.04534445
119MP0000383_abnormal_hair_follicle1.03950724
120MP0004858_abnormal_nervous_system1.03701598
121MP0000604_amyloidosis1.01669921
122MP0000538_abnormal_urinary_bladder1.00513081
123MP0002148_abnormal_hypersensitivity_rea0.99989515
124MP0000762_abnormal_tongue_morphology0.99690338
125MP0002429_abnormal_blood_cell0.99244059
126MP0005164_abnormal_response_to0.99192226
127MP0001299_abnormal_eye_distance/0.99002876
128MP0002405_respiratory_system_inflammati0.98184344
129MP0001243_abnormal_dermal_layer0.98061244
130MP0001533_abnormal_skeleton_physiology0.96941705
131MP0002277_abnormal_respiratory_mucosa0.96748107
132MP0000767_abnormal_smooth_muscle0.96611006
133MP0002653_abnormal_ependyma_morphology0.96274243
134MP0000759_abnormal_skeletal_muscle0.96113924
135MP0005387_immune_system_phenotype0.96056021
136MP0001790_abnormal_immune_system0.96056021
137MP0004133_heterotaxia0.95455024
138MP0002396_abnormal_hematopoietic_system0.94934573
139MP0004742_abnormal_vestibular_system0.94394391
140MP0003075_altered_response_to0.94051513
141MP0003938_abnormal_ear_development0.94024175
142MP0000689_abnormal_spleen_morphology0.90296629
143MP0002152_abnormal_brain_morphology0.89636131
144MP0002882_abnormal_neuron_morphology0.89126005
145MP0005621_abnormal_cell_physiology0.88850451
146MP0008260_abnormal_autophagy0.88705251
147MP0001905_abnormal_dopamine_level0.87946156
148MP0008932_abnormal_embryonic_tissue0.87693286
149MP0003183_abnormal_peptide_metabolism0.87594475
150MP0005248_abnormal_Harderian_gland0.87533317
151MP0001663_abnormal_digestive_system0.86969480
152MP0001958_emphysema0.86717447
153MP0005409_darkened_coat_color0.86565388
154MP0009053_abnormal_anal_canal0.86117246
155MP0010386_abnormal_urinary_bladder0.86057533
156MP0010094_abnormal_chromosome_stability0.86018291
157MP0002282_abnormal_trachea_morphology0.84584526
158MP0002067_abnormal_sensory_capabilities0.83771911
159MP0003693_abnormal_embryo_hatching0.82731664
160MP0000015_abnormal_ear_pigmentation0.81134673
161MP0000049_abnormal_middle_ear0.81052003
162MP0005508_abnormal_skeleton_morphology0.79827140
163MP0009745_abnormal_behavioral_response0.79597062
164MP0003191_abnormal_cellular_cholesterol0.79442714
165MP0008569_lethality_at_weaning0.79284486
166MP0002089_abnormal_postnatal_growth/wei0.79150312
167MP0001984_abnormal_olfaction0.78533683
168MP0002166_altered_tumor_susceptibility0.77227345
169MP0001879_abnormal_lymphatic_vessel0.76913254
170MP0005165_increased_susceptibility_to0.76398361
171MP0003436_decreased_susceptibility_to0.76384768
172MP0001545_abnormal_hematopoietic_system0.76325753
173MP0005397_hematopoietic_system_phenotyp0.76325753
174MP0004924_abnormal_behavior0.76148433
175MP0005386_behavior/neurological_phenoty0.76148433
176MP0003077_abnormal_cell_cycle0.76005645
177MP0010771_integument_phenotype0.74547919
178MP0002697_abnormal_eye_size0.73220245
179MP0009763_increased_sensitivity_to0.73054368
180MP0004087_abnormal_muscle_fiber0.71719160
181MP0000749_muscle_degeneration0.71191641
182MP0003828_pulmonary_edema0.70814271
183MP0005390_skeleton_phenotype0.70342001
184MP0000428_abnormal_craniofacial_morphol0.69840669
185MP0005666_abnormal_adipose_tissue0.69826095
186MP0003115_abnormal_respiratory_system0.69204368
187MP0004185_abnormal_adipocyte_glucose0.69068871
188MP0005166_decreased_susceptibility_to0.68856902
189MP0004197_abnormal_fetal_growth/weight/0.66967682
190MP0003656_abnormal_erythrocyte_physiolo0.66773615
191MP0001191_abnormal_skin_condition0.65831633
192MP0002295_abnormal_pulmonary_circulatio0.65426994
193MP0005384_cellular_phenotype0.65249495
194MP0001727_abnormal_embryo_implantation0.64879632

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.93123788
2Atrophic scars (HP:0001075)3.84845819
3Elevated erythrocyte sedimentation rate (HP:0003565)3.73762433
4Polyphagia (HP:0002591)3.68313909
5Amyotrophic lateral sclerosis (HP:0007354)3.41340290
6Lissencephaly (HP:0001339)3.27895864
7Type 1 muscle fiber predominance (HP:0003803)3.11077590
8Thick nail (HP:0001805)3.10553933
9Limb dystonia (HP:0002451)3.10210633
10Distal lower limb amyotrophy (HP:0008944)3.03137893
11Failure to thrive in infancy (HP:0001531)3.00893905
12Protrusio acetabuli (HP:0003179)3.00877335
13Reticulocytopenia (HP:0001896)2.88099548
14Spinal rigidity (HP:0003306)2.88099015
15Increased mean platelet volume (HP:0011877)2.81471193
16Progressive inability to walk (HP:0002505)2.79346733
17Atrophy/Degeneration involving motor neurons (HP:0007373)2.76734678
18Papilledema (HP:0001085)2.76649749
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.73812396
20Recurrent bronchitis (HP:0002837)2.71401516
21Severe combined immunodeficiency (HP:0004430)2.71391417
22Hypoplasia of the brainstem (HP:0002365)2.70791804
23Aplasia/Hypoplasia of the brainstem (HP:0007362)2.70791804
24Large eyes (HP:0001090)2.70670067
25Nemaline bodies (HP:0003798)2.65918897
26Muscle fiber inclusion bodies (HP:0100299)2.61830085
27Lower limb amyotrophy (HP:0007210)2.58439316
28Increased connective tissue (HP:0009025)2.55235775
29Ankle contracture (HP:0006466)2.54942092
30Abnormality of liposaccharide metabolism (HP:0010968)2.54266562
31Abnormality of glycosphingolipid metabolism (HP:0004343)2.54266562
32Abnormality of glycolipid metabolism (HP:0010969)2.54266562
33Milia (HP:0001056)2.50802687
34Shoulder girdle muscle weakness (HP:0003547)2.50377150
35Mutism (HP:0002300)2.48039879
36Difficulty climbing stairs (HP:0003551)2.45695522
37Hyperacusis (HP:0010780)2.44759909
38Achilles tendon contracture (HP:0001771)2.42406573
39Abnormal platelet volume (HP:0011876)2.40187479
40Poor suck (HP:0002033)2.37667681
41Pelvic girdle muscle weakness (HP:0003749)2.37074810
42Neurofibrillary tangles (HP:0002185)2.35075629
43Fragile skin (HP:0001030)2.34043550
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.33969388
45Alopecia of scalp (HP:0002293)2.32917937
46Follicular hyperkeratosis (HP:0007502)2.31397874
47Optic nerve coloboma (HP:0000588)2.28955516
48Insidious onset (HP:0003587)2.27596556
49Termporal pattern (HP:0011008)2.27596556
50Thyroiditis (HP:0100646)2.26499296
51Abnormality of the intervertebral disk (HP:0005108)2.25925579
52Abnormality of the Achilles tendon (HP:0005109)2.25738903
53Abnormality of cells of the erythroid lineage (HP:0012130)2.25130578
54Esotropia (HP:0000565)2.24499546
55Cerebral inclusion bodies (HP:0100314)2.23178028
56Pallor (HP:0000980)2.23143620
57T lymphocytopenia (HP:0005403)2.22493768
58Fragile nails (HP:0001808)2.21595554
59Exotropia (HP:0000577)2.21164837
60Combined immunodeficiency (HP:0005387)2.21126650
61Vascular tortuosity (HP:0004948)2.21010791
62Ankle clonus (HP:0011448)2.19454794
63Deep palmar crease (HP:0006191)2.19323261
64Slender build (HP:0001533)2.18397667
65Recurrent cutaneous fungal infections (HP:0011370)2.18240209
66Chronic mucocutaneous candidiasis (HP:0002728)2.18240209
67Plantar hyperkeratosis (HP:0007556)2.15954652
68Agammaglobulinemia (HP:0004432)2.14723827
69Diminished motivation (HP:0000745)2.14414882
70Mildly elevated creatine phosphokinase (HP:0008180)2.14315207
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.14063685
72Abnormality of skeletal muscle fiber size (HP:0012084)2.12494467
73Natal tooth (HP:0000695)2.11310106
74Abnormality of T cell number (HP:0011839)2.10934254
75Distal upper limb amyotrophy (HP:0007149)2.10525202
76Upper limb amyotrophy (HP:0009129)2.10525202
77Arterial tortuosity (HP:0005116)2.08235739
78Abnormality of the musculature of the pelvis (HP:0001469)2.06920657
79Abnormality of the hip-girdle musculature (HP:0001445)2.06920657
80Increased variability in muscle fiber diameter (HP:0003557)2.05371472
81Loss of speech (HP:0002371)2.04606211
82Hypoventilation (HP:0002791)2.04289614
83Limb-girdle muscle atrophy (HP:0003797)2.02863748
84Limb-girdle muscle weakness (HP:0003325)2.01851046
85Megalocornea (HP:0000485)2.01741013
86Iris hypopigmentation (HP:0007730)2.01678154
87Abnormality of nail color (HP:0100643)2.01176042
88Supranuclear gaze palsy (HP:0000605)2.00556523
89Increased IgM level (HP:0003496)2.00080353
90Bladder diverticulum (HP:0000015)1.98834693
91Menorrhagia (HP:0000132)1.98774159
92High anterior hairline (HP:0009890)1.98335898
93IgG deficiency (HP:0004315)1.98229397
94Apathy (HP:0000741)1.97961964
95Sleep apnea (HP:0010535)1.97366563
96Myositis (HP:0100614)1.97180232
97Sacral dimple (HP:0000960)1.97074627
98Abnormal number of erythroid precursors (HP:0012131)1.96708770
99Spondylolisthesis (HP:0003302)1.96417545
100Inability to walk (HP:0002540)1.96381503
101Cervical subluxation (HP:0003308)1.94148641
102Anterior segment dysgenesis (HP:0007700)1.93524839
103Distal lower limb muscle weakness (HP:0009053)1.92657118
104Concave nail (HP:0001598)1.92597474
105Hammertoe (HP:0001765)1.92588353
106Vertebral compression fractures (HP:0002953)1.92329743
107Visual hallucinations (HP:0002367)1.92266964
108Nail dystrophy (HP:0008404)1.91855728
109Centrally nucleated skeletal muscle fibers (HP:0003687)1.91804874
110Abnormal hair whorl (HP:0010721)1.91769236
111Growth hormone deficiency (HP:0000824)1.91715509
112Wormian bones (HP:0002645)1.91464588
113Abnormal eating behavior (HP:0100738)1.90298593
114Hip dysplasia (HP:0001385)1.90102060
115Abnormality of cells of the lymphoid lineage (HP:0012140)1.90037246
116Onycholysis (HP:0001806)1.89735947
117Generalized amyotrophy (HP:0003700)1.89071866
118Heterochromia iridis (HP:0001100)1.88916936
119Dysostosis multiplex (HP:0000943)1.88520081
120Colon cancer (HP:0003003)1.88052731
121Lymphopenia (HP:0001888)1.87956251
122Aortic dissection (HP:0002647)1.87718878
123Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87637147
124Adducted thumb (HP:0001181)1.87249149
125Inappropriate behavior (HP:0000719)1.86549866
126Obstructive lung disease (HP:0006536)1.86361251
127Chronic obstructive pulmonary disease (HP:0006510)1.86361251
128Abnormality of the labia minora (HP:0012880)1.86069243
129Papillary thyroid carcinoma (HP:0002895)1.85263724
130Recurrent fungal infections (HP:0002841)1.84945654
131B lymphocytopenia (HP:0010976)1.84941733
132Abnormality of B cell number (HP:0010975)1.84941733
133Pachygyria (HP:0001302)1.84898329
134Exercise-induced muscle cramps (HP:0003710)1.84222928
135Abnormality of oral frenula (HP:0000190)1.84072874
136Mitral stenosis (HP:0001718)1.83926443
137Upper motor neuron abnormality (HP:0002127)1.83224208
138Pointed chin (HP:0000307)1.82449450
139Progressive muscle weakness (HP:0003323)1.82202278
140Interstitial pulmonary disease (HP:0006530)1.81862024
141Protruding tongue (HP:0010808)1.81613747
142Osteolytic defects of the phalanges of the hand (HP:0009771)1.80733157
143Osteolytic defects of the hand bones (HP:0009699)1.80733157
144Polymicrogyria (HP:0002126)1.80675050
145Disinhibition (HP:0000734)1.80363604
146Thin bony cortex (HP:0002753)1.80289290
147Degeneration of anterior horn cells (HP:0002398)1.80100757
148Abnormality of the anterior horn cell (HP:0006802)1.80100757
149Myocardial infarction (HP:0001658)1.78871015
150Autoamputation (HP:0001218)1.78845211
151Patellar aplasia (HP:0006443)1.77813587
152Nuclear cataract (HP:0100018)1.77285802
153Generalized hypotonia (HP:0001290)1.75994557
154Increased density of long bones (HP:0006392)1.75949953
155Thoracolumbar scoliosis (HP:0002944)1.75746701
156Genu recurvatum (HP:0002816)1.75316273
157Back pain (HP:0003418)1.75187659
158Short philtrum (HP:0000322)1.75047722
159Abnormality of T cells (HP:0002843)1.74680147
160Abnormal auditory evoked potentials (HP:0006958)1.74497812
161Purpura (HP:0000979)1.74250329
162Palmar hyperkeratosis (HP:0010765)1.73369131
163Focal seizures (HP:0007359)1.73280414
164Myokymia (HP:0002411)1.73189385
165Wrist flexion contracture (HP:0001239)1.73077164
166Palmoplantar hyperkeratosis (HP:0000972)1.73038427
167Amblyopia (HP:0000646)1.72731900
168Reduced subcutaneous adipose tissue (HP:0003758)1.72670413
169Rimmed vacuoles (HP:0003805)1.72481626
170Asymmetric septal hypertrophy (HP:0001670)1.71973394
171Panhypogammaglobulinemia (HP:0003139)1.71898985
172Meningitis (HP:0001287)1.70966539
173Syringomyelia (HP:0003396)1.70910135
174Spinal cord lesions (HP:0100561)1.70910135
175Abnormality of eosinophils (HP:0001879)1.70881104
176Broad-based gait (HP:0002136)1.70348435
177Aplasia/Hypoplasia of the patella (HP:0006498)1.69933561
178Renal duplication (HP:0000075)1.69026741
179Scapular winging (HP:0003691)1.68838739
180Elbow flexion contracture (HP:0002987)1.68120616
181Ulnar bowing (HP:0003031)1.67260515
182Hand muscle atrophy (HP:0009130)1.65966287
183Woolly hair (HP:0002224)1.65596368
184Cortical dysplasia (HP:0002539)1.65503014
185Asymmetry of the thorax (HP:0001555)1.65089695
186Spastic diplegia (HP:0001264)1.64922733
187Nasal speech (HP:0001611)1.63572753
188Short nail (HP:0001799)1.63213713
189Decreased muscle mass (HP:0003199)1.63107333
190Thick lower lip vermilion (HP:0000179)1.63093074
191Cutis marmorata (HP:0000965)1.62938368
192IgM deficiency (HP:0002850)1.61725335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.85867927
2SIK34.62227880
3IRAK33.93489885
4DYRK23.21831762
5LATS23.20306394
6MAP3K123.11892369
7MKNK22.82636885
8TAOK12.74887403
9KSR12.71480137
10TESK22.56033573
11DDR22.55936694
12RIPK12.52225677
13MAP3K32.47074295
14PDGFRA2.46149182
15NTRK22.42825142
16TTN2.35525940
17MINK12.22445237
18MAP3K92.18984771
19EPHB22.15354561
20TLK12.13336822
21SIK22.07675824
22MOS2.04516223
23EPHA32.01471668
24LIMK12.00977726
25ERBB32.00395998
26LATS11.91938177
27MKNK11.91583716
28MAPK131.84643240
29BCR1.82133073
30MAP3K101.78768964
31GRK71.78209680
32UHMK11.72715896
33FGFR41.72316496
34CDK191.71964746
35MAP4K11.68869564
36ARAF1.67655753
37TYRO31.66224338
38MAP3K51.63091797
39TXK1.57427866
40PRPF4B1.54155032
41EIF2AK11.50794391
42ABL21.46564344
43ACVR1B1.46412589
44NTRK11.44606791
45MAP2K31.44471796
46PAK41.35388977
47PTK21.34607073
48MAP3K141.33264062
49GRK61.28837291
50ITK1.28538936
51EEF2K1.25431222
52CDK121.25152739
53DYRK31.24423432
54TESK11.21146196
55MET1.18725903
56SYK1.17072124
57TGFBR21.14975438
58TNIK1.14033088
59STK241.09629039
60BLK1.08888508
61TGFBR11.07346680
62NME21.01877998
63NEK91.01741897
64ERBB41.00908252
65EPHB11.00404762
66ZAP701.00110428
67MATK0.97611623
68MAP3K60.96966733
69MAP3K110.94397364
70CDK180.92815733
71FGFR20.91433030
72MST1R0.89306569
73STK38L0.88814966
74BMX0.88585853
75OBSCN0.87330801
76MAP2K70.86944596
77PAK20.82264310
78BMPR1B0.81874566
79CDK140.80627078
80IRAK20.80290637
81CDK60.78042556
82CDC42BPA0.77884545
83STK30.77248993
84SRPK10.75980932
85EPHA20.75867468
86BRD40.75582295
87IRAK40.75257170
88PDGFRB0.75156073
89TBK10.74844813
90CDK11A0.71956669
91DAPK10.70223957
92CDK150.69665378
93MYLK0.68747609
94BTK0.68165979
95RAF10.68129848
96FES0.68103896
97CCNB10.66860379
98PIM20.65634901
99CDK50.64921523
100WNK30.64561462
101KIT0.63318083
102FGFR30.62801198
103HCK0.62302756
104CDC70.62259527
105FGR0.62144256
106MAPK40.61904120
107ILK0.60912824
108CLK10.60750303
109AURKA0.60677546
110SIK10.59783238
111SCYL20.57014202
112MAPK90.56240318
113DYRK1A0.55650158
114LCK0.54525456
115ERBB20.53538890
116KSR20.53256386
117ROCK20.52354321
118VRK10.52133919
119PKN20.52044609
120NME10.51215584
121IRAK10.50530239
122JAK10.49764019
123MARK20.49602038
124MAP3K80.48259333
125DAPK20.48087239
126CSNK1G30.47417502
127PKN10.46763299
128PHKG20.45179353
129PHKG10.45179353
130BRAF0.45008556
131FYN0.44990490
132CSNK1G20.44664373
133STK160.44241946
134DYRK1B0.43907715
135RPS6KA20.43885639
136RPS6KA40.43832193
137ICK0.43815087
138BMPR20.43529459
139MAP3K40.42569979
140PAK60.41866211
141CHUK0.41849076
142MTOR0.40827089
143STK100.40675698
144NTRK30.40575775
145CSNK1A1L0.40240770
146MAP3K10.39728432
147JAK30.39278826
148FLT30.38086774
149IKBKE0.37878547
150TRIB30.37569927
151LRRK20.36298918
152LYN0.36004371
153CASK0.35823440
154DMPK0.35235090
155ATR0.34985389
156CAMK2G0.33784464
157FGFR10.33636796
158CDK90.33395370
159HIPK20.32952689
160LMTK20.31628144
161GSK3A0.30846692
162RET0.30284776
163DAPK30.29981431
164CSF1R0.29779590
165RPS6KA10.29497895
166TAOK20.28256222
167TYK20.26244739
168CDK80.23253490

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.50023212
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.46081974
3Primary immunodeficiency_Homo sapiens_hsa053402.24324032
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.17045142
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.10332078
6Bladder cancer_Homo sapiens_hsa052192.02240650
7ECM-receptor interaction_Homo sapiens_hsa045121.98115004
8Amoebiasis_Homo sapiens_hsa051461.91919951
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.90640591
10T cell receptor signaling pathway_Homo sapiens_hsa046601.88637684
11Colorectal cancer_Homo sapiens_hsa052101.87026823
12DNA replication_Homo sapiens_hsa030301.84097339
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74660205
14Malaria_Homo sapiens_hsa051441.72629331
15Axon guidance_Homo sapiens_hsa043601.70518826
16Spliceosome_Homo sapiens_hsa030401.67961291
17Viral myocarditis_Homo sapiens_hsa054161.62539617
18Focal adhesion_Homo sapiens_hsa045101.60511277
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60186569
20Prion diseases_Homo sapiens_hsa050201.54911274
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51573294
22Small cell lung cancer_Homo sapiens_hsa052221.51379321
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49877675
24Adherens junction_Homo sapiens_hsa045201.48544125
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.47364343
26Proteoglycans in cancer_Homo sapiens_hsa052051.46176182
27Lysosome_Homo sapiens_hsa041421.45608796
28Pertussis_Homo sapiens_hsa051331.42358668
29Shigellosis_Homo sapiens_hsa051311.41201725
30Graft-versus-host disease_Homo sapiens_hsa053321.32924471
31Base excision repair_Homo sapiens_hsa034101.32886622
32Dilated cardiomyopathy_Homo sapiens_hsa054141.30171362
33Steroid biosynthesis_Homo sapiens_hsa001001.29420128
34B cell receptor signaling pathway_Homo sapiens_hsa046621.27729854
35Legionellosis_Homo sapiens_hsa051341.25579727
36VEGF signaling pathway_Homo sapiens_hsa043701.25432851
37Proteasome_Homo sapiens_hsa030501.21272905
38Endometrial cancer_Homo sapiens_hsa052131.20262601
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19761743
40Antigen processing and presentation_Homo sapiens_hsa046121.19348850
41Allograft rejection_Homo sapiens_hsa053301.16648790
42Hepatitis C_Homo sapiens_hsa051601.16485328
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.15431044
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11705385
45Leishmaniasis_Homo sapiens_hsa051401.10057117
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10022792
47Measles_Homo sapiens_hsa051621.08123454
48Hepatitis B_Homo sapiens_hsa051611.06460080
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06123748
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.04511822
51Mismatch repair_Homo sapiens_hsa034301.04246687
52Vibrio cholerae infection_Homo sapiens_hsa051101.04177967
53Pancreatic cancer_Homo sapiens_hsa052121.03528077
54Other glycan degradation_Homo sapiens_hsa005111.00870609
55Salmonella infection_Homo sapiens_hsa051321.00719403
56Chronic myeloid leukemia_Homo sapiens_hsa052201.00282512
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99832954
58Sulfur metabolism_Homo sapiens_hsa009200.99637228
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99487653
60Basal cell carcinoma_Homo sapiens_hsa052170.99413128
61Cell cycle_Homo sapiens_hsa041100.98789005
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98570263
63mRNA surveillance pathway_Homo sapiens_hsa030150.98565337
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98359156
65Rheumatoid arthritis_Homo sapiens_hsa053230.98048004
66Epstein-Barr virus infection_Homo sapiens_hsa051690.97929531
67Sphingolipid metabolism_Homo sapiens_hsa006000.96890590
68HTLV-I infection_Homo sapiens_hsa051660.96218186
69Notch signaling pathway_Homo sapiens_hsa043300.94955222
70Pyrimidine metabolism_Homo sapiens_hsa002400.94386769
71Apoptosis_Homo sapiens_hsa042100.93971881
72Osteoclast differentiation_Homo sapiens_hsa043800.92312254
73Alcoholism_Homo sapiens_hsa050340.92310465
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.92254729
75N-Glycan biosynthesis_Homo sapiens_hsa005100.91065535
76Non-small cell lung cancer_Homo sapiens_hsa052230.90140673
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89793266
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87382912
79RNA polymerase_Homo sapiens_hsa030200.85902117
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84303412
81Oocyte meiosis_Homo sapiens_hsa041140.84287440
82African trypanosomiasis_Homo sapiens_hsa051430.83291005
83Dopaminergic synapse_Homo sapiens_hsa047280.82946263
84Nicotine addiction_Homo sapiens_hsa050330.82599150
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80245384
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.80054979
87ErbB signaling pathway_Homo sapiens_hsa040120.79068009
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77299316
89Wnt signaling pathway_Homo sapiens_hsa043100.77247983
90Tuberculosis_Homo sapiens_hsa051520.75886340
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74760420
92Cholinergic synapse_Homo sapiens_hsa047250.74437554
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.74033735
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.73751922
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73668341
96Platelet activation_Homo sapiens_hsa046110.73577029
97Acute myeloid leukemia_Homo sapiens_hsa052210.73255728
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71771418
99Herpes simplex infection_Homo sapiens_hsa051680.71420078
100Galactose metabolism_Homo sapiens_hsa000520.71328734
101Hematopoietic cell lineage_Homo sapiens_hsa046400.71209910
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70996613
103Hippo signaling pathway_Homo sapiens_hsa043900.70857676
104Parkinsons disease_Homo sapiens_hsa050120.70676424
105Insulin signaling pathway_Homo sapiens_hsa049100.69826579
106Gap junction_Homo sapiens_hsa045400.69557688
107Type I diabetes mellitus_Homo sapiens_hsa049400.69504739
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69354473
109Chemokine signaling pathway_Homo sapiens_hsa040620.69195509
110Glioma_Homo sapiens_hsa052140.67247484
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67162099
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66895668
113MicroRNAs in cancer_Homo sapiens_hsa052060.66321016
114Melanoma_Homo sapiens_hsa052180.66213658
115Synaptic vesicle cycle_Homo sapiens_hsa047210.65063128
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.64839921
117Viral carcinogenesis_Homo sapiens_hsa052030.64412571
118Thyroid cancer_Homo sapiens_hsa052160.64331882
119Endocytosis_Homo sapiens_hsa041440.64031562
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63023431
121Renal cell carcinoma_Homo sapiens_hsa052110.62932181
122RNA transport_Homo sapiens_hsa030130.62699232
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61835844
124Prostate cancer_Homo sapiens_hsa052150.61613411
125p53 signaling pathway_Homo sapiens_hsa041150.61568205
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60916158
127TGF-beta signaling pathway_Homo sapiens_hsa043500.60838048
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60028338
129Prolactin signaling pathway_Homo sapiens_hsa049170.59627709
130Influenza A_Homo sapiens_hsa051640.59565537
131Cocaine addiction_Homo sapiens_hsa050300.59281422
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58507394
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.58321653
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57557960
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57413779
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56087083
137Oxytocin signaling pathway_Homo sapiens_hsa049210.55691654
138Complement and coagulation cascades_Homo sapiens_hsa046100.55569218
139Pathways in cancer_Homo sapiens_hsa052000.54322014
140TNF signaling pathway_Homo sapiens_hsa046680.54114511
141Systemic lupus erythematosus_Homo sapiens_hsa053220.53906675
142Nucleotide excision repair_Homo sapiens_hsa034200.53489060
143Tight junction_Homo sapiens_hsa045300.53410915
144Melanogenesis_Homo sapiens_hsa049160.52088545
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.51967169
146Toxoplasmosis_Homo sapiens_hsa051450.51943935
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50463064
148Rap1 signaling pathway_Homo sapiens_hsa040150.50369435
149Phagosome_Homo sapiens_hsa041450.48394589
150Asthma_Homo sapiens_hsa053100.47830844

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