PANX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.79105022
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.50514026
3locomotory exploration behavior (GO:0035641)6.28072499
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.94672569
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.84063548
6vocalization behavior (GO:0071625)5.54172209
7synaptic vesicle exocytosis (GO:0016079)5.46057892
8glutamate secretion (GO:0014047)5.44124821
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.33320661
10regulation of synaptic vesicle exocytosis (GO:2000300)5.30913654
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.25439871
12neuronal action potential propagation (GO:0019227)4.96352079
13regulation of glutamate receptor signaling pathway (GO:1900449)4.96291871
14neurotransmitter secretion (GO:0007269)4.90794673
15regulation of synaptic vesicle transport (GO:1902803)4.79267310
16regulation of neuronal synaptic plasticity (GO:0048168)4.75810448
17exploration behavior (GO:0035640)4.71853631
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.69482881
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.65204337
20protein localization to synapse (GO:0035418)4.54611612
21sodium ion export (GO:0071436)4.50361715
22gamma-aminobutyric acid transport (GO:0015812)4.50112745
23cellular potassium ion homeostasis (GO:0030007)4.48181705
24layer formation in cerebral cortex (GO:0021819)4.43247864
25regulation of synapse structural plasticity (GO:0051823)4.41470706
26glycine transport (GO:0015816)4.24316350
27dendritic spine morphogenesis (GO:0060997)4.18969377
28proline transport (GO:0015824)4.18255044
29synaptic transmission, glutamatergic (GO:0035249)4.14156519
30long-term memory (GO:0007616)4.09890797
31cerebellar granule cell differentiation (GO:0021707)4.07247069
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.06486078
33neuromuscular process controlling posture (GO:0050884)4.00019600
34glutamate receptor signaling pathway (GO:0007215)3.99973784
35neurotransmitter transport (GO:0006836)3.93780437
36positive regulation of membrane potential (GO:0045838)3.93331042
37neuron cell-cell adhesion (GO:0007158)3.91246031
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.90307251
39neurotransmitter-gated ion channel clustering (GO:0072578)3.88436692
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85286107
41neuron-neuron synaptic transmission (GO:0007270)3.85225134
42activation of protein kinase A activity (GO:0034199)3.83359761
43neuromuscular process controlling balance (GO:0050885)3.83045804
44amino acid import (GO:0043090)3.74127202
45positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.73311891
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.72241612
47cerebellar Purkinje cell differentiation (GO:0021702)3.69161231
48cell communication by electrical coupling (GO:0010644)3.66260016
49regulation of neurotransmitter levels (GO:0001505)3.65888363
50negative regulation of cell killing (GO:0031342)3.65591711
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65591711
52regulation of synaptic plasticity (GO:0048167)3.61799793
53synaptic vesicle endocytosis (GO:0048488)3.54901870
54regulation of postsynaptic membrane potential (GO:0060078)3.53849614
55positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53693411
56regulation of neurotransmitter secretion (GO:0046928)3.50746266
57positive regulation of synapse maturation (GO:0090129)3.49189130
58regulation of dendritic spine morphogenesis (GO:0061001)3.49045025
59transmission of nerve impulse (GO:0019226)3.48694348
60positive regulation by symbiont of host defense response (GO:0052509)3.46176217
61modulation by symbiont of host defense response (GO:0052031)3.46176217
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46176217
63modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46176217
64positive regulation by organism of defense response of other organism involved in symbiotic interact3.46176217
65modulation by symbiont of host immune response (GO:0052553)3.46176217
66L-amino acid import (GO:0043092)3.43772984
67regulation of ARF protein signal transduction (GO:0032012)3.43165083
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.42103033
69regulation of T-helper 2 cell differentiation (GO:0045628)3.40764443
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.37620840
71auditory behavior (GO:0031223)3.34973176
72potassium ion import (GO:0010107)3.34492300
73prepulse inhibition (GO:0060134)3.33182653
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32918058
75membrane depolarization during action potential (GO:0086010)3.31468570
76neuronal ion channel clustering (GO:0045161)3.30678812
77macrophage activation involved in immune response (GO:0002281)3.28624763
78response to auditory stimulus (GO:0010996)3.27902484
79regulation of neurotransmitter transport (GO:0051588)3.27790115
80regulation of vesicle fusion (GO:0031338)3.27754432
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22599043
82signal complex assembly (GO:0007172)3.21728431
83positive regulation of neurotransmitter transport (GO:0051590)3.20897247
84long-term synaptic potentiation (GO:0060291)3.20829020
85dendrite morphogenesis (GO:0048813)3.19525589
86vesicle transport along microtubule (GO:0047496)3.18476999
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.18433079
88neuron recognition (GO:0008038)3.17834516
89response to peptidoglycan (GO:0032494)3.14929312
90membrane depolarization (GO:0051899)3.14754798
91positive regulation of Rap GTPase activity (GO:0032854)3.13951606
92gamma-aminobutyric acid signaling pathway (GO:0007214)3.12569113
93neuromuscular process (GO:0050905)3.12399707
94cellular sodium ion homeostasis (GO:0006883)3.12327551
95negative regulation of erythrocyte differentiation (GO:0045647)3.12217368
96positive regulation of neurotransmitter secretion (GO:0001956)3.11483743
97potassium ion homeostasis (GO:0055075)3.11335449
98dendritic spine organization (GO:0097061)3.10974458
99membrane hyperpolarization (GO:0060081)3.10886652
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.04986000
101regulation of synaptic transmission (GO:0050804)3.03546553
102innervation (GO:0060384)3.03398550
103regulation of amyloid precursor protein catabolic process (GO:1902991)3.03230745
104G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02992294
105positive regulation of synaptic transmission (GO:0050806)3.01925481
106positive regulation of dendritic spine development (GO:0060999)3.01805221
107negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01103974
108chemosensory behavior (GO:0007635)3.00381203
109learning (GO:0007612)3.00090905
110cytoskeletal anchoring at plasma membrane (GO:0007016)3.00030248
111social behavior (GO:0035176)2.99969778
112intraspecies interaction between organisms (GO:0051703)2.99969778
113cerebellar Purkinje cell layer development (GO:0021680)2.98170800
114adult walking behavior (GO:0007628)2.96897964
115regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95589284
116regulation of regulated secretory pathway (GO:1903305)2.95538461
117* synaptic transmission (GO:0007268)2.95077098
118positive regulation of potassium ion transmembrane transport (GO:1901381)2.93470009
119regulation of beta-amyloid formation (GO:1902003)2.93117865
120axonal fasciculation (GO:0007413)2.92542141
121regulation of ARF GTPase activity (GO:0032312)2.90482979
122cell migration in hindbrain (GO:0021535)2.81533520
123positive regulation of cellular amide metabolic process (GO:0034250)2.80253510
124peptidyl-tyrosine autophosphorylation (GO:0038083)2.77255255
125regulation of Rap GTPase activity (GO:0032317)2.73909676
126negative regulation of dendrite morphogenesis (GO:0050774)2.73348099
127regulation of synapse maturation (GO:0090128)2.72684488
128detection of other organism (GO:0098543)2.72273838
129neutrophil activation involved in immune response (GO:0002283)2.69141159
130protein localization to endosome (GO:0036010)2.68056564
131antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.66682724
132regulation of cellular amide metabolic process (GO:0034248)2.62822027
133antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.61443675
134negative regulation of lymphocyte mediated immunity (GO:0002707)2.59199817
135detection of molecule of bacterial origin (GO:0032490)2.59152577
136detection of bacterium (GO:0016045)2.58966573
137negative regulation of type 2 immune response (GO:0002829)2.56739687
138negative regulation of toll-like receptor signaling pathway (GO:0034122)2.54388138
139positive regulation of protein dephosphorylation (GO:0035307)2.53737222
140regulation of exocytosis (GO:0017157)2.53711099
141regulation of leukocyte degranulation (GO:0043300)2.52851604
142germinal center formation (GO:0002467)2.51937150
143positive regulation of regulated secretory pathway (GO:1903307)2.51710556
144regulation of myeloid leukocyte mediated immunity (GO:0002886)2.51295250
145response to manganese ion (GO:0010042)2.50432964
146negative regulation of leukocyte mediated immunity (GO:0002704)2.50201141
147detection of external biotic stimulus (GO:0098581)2.43592434
148antigen processing and presentation of endogenous antigen (GO:0019883)2.43401170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.01098981
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11419465
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06944221
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06187120
5REST_21632747_ChIP-Seq_MESCs_Mouse2.92370369
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.91072817
7DROSHA_22980978_ChIP-Seq_HELA_Human2.86612033
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80027398
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80027398
10GBX2_23144817_ChIP-Seq_PC3_Human2.74992559
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73047080
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65612964
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64954894
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56373964
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.51586276
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.49983085
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49064359
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45760223
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.45699982
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.40422396
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40014607
22* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.38998987
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.36484378
24VDR_21846776_ChIP-Seq_THP-1_Human2.25704017
25KDM2B_26808549_Chip-Seq_DND41_Human2.25325435
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.23174131
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.16586454
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12527468
29TCF7_22412390_ChIP-Seq_EML_Mouse2.08605661
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03338889
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01513827
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97925437
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.83770094
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77798501
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77718744
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.75343873
37RACK7_27058665_Chip-Seq_MCF-7_Human1.74769439
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.72358793
39AR_21572438_ChIP-Seq_LNCaP_Human1.67996865
40P68_20966046_ChIP-Seq_HELA_Human1.67425592
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61867136
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.61397172
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.61105374
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57474576
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56814650
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56303739
47VDR_24763502_ChIP-Seq_THP-1_Human1.54137695
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.52341616
49MYC_22102868_ChIP-Seq_BL_Human1.52291634
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50987928
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48317661
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48091841
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.46436729
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46152608
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.45168179
56KDM2B_26808549_Chip-Seq_K562_Human1.44682677
57SPI1_23127762_ChIP-Seq_K562_Human1.43125815
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42864623
59CREB1_26743006_Chip-Seq_LNCaP_Human1.42091190
60* RING1B_27294783_Chip-Seq_ESCs_Mouse1.40589997
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39995676
62SMAD4_21799915_ChIP-Seq_A2780_Human1.39809882
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39240579
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38449542
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38360764
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38355924
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36616499
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36348286
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.35895830
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34883352
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33538486
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33040586
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32440923
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28755243
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28351277
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27844488
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.25479567
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25237161
79ZNF274_21170338_ChIP-Seq_K562_Hela1.24905465
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23909697
81AR_19668381_ChIP-Seq_PC3_Human1.23341104
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.23039618
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.22723140
84MAF_26560356_Chip-Seq_TH1_Human1.22611208
85BCOR_27268052_Chip-Seq_Bcells_Human1.22553228
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22183581
87SCL_19346495_ChIP-Seq_HPC-7_Human1.21987192
88GATA1_19941826_ChIP-Seq_K562_Human1.20032074
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19499798
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18970942
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18520422
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18423997
93* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16553767
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15159704
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14864341
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14540257
97MAF_26560356_Chip-Seq_TH2_Human1.13894962
98BCL6_27268052_Chip-Seq_Bcells_Human1.13191651
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.11920818
100UTX_26944678_Chip-Seq_JUKART_Human1.09827184
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09154025
102BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07569602
103SA1_27219007_Chip-Seq_Bcells_Human1.06818718
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05880304
105STAT3_23295773_ChIP-Seq_U87_Human1.05581092
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.05541509
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05193923
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05113145
109ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04826618
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04416149
111IRF8_27001747_Chip-Seq_BMDM_Mouse1.04282291
112AR_25329375_ChIP-Seq_VCAP_Human1.03922456
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03872005
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02992796
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02408419
116EGR1_19032775_ChIP-ChIP_M12_Human1.02261649
117TET1_21490601_ChIP-Seq_MESCs_Mouse1.02216513
118IRF8_22096565_ChIP-ChIP_GC-B_Human1.00356018
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99972517
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99312950
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99140295
122CTCF_27219007_Chip-Seq_Bcells_Human0.98951352
123TAF15_26573619_Chip-Seq_HEK293_Human0.97998955
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.97985792
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96156487
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95049617
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94972471
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94088870
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93798168
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.93732192
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93680897
132P300_19829295_ChIP-Seq_ESCs_Human0.91327630
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.91224437
134TCF4_23295773_ChIP-Seq_U87_Human0.90384878
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89748797
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.88039592
137SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87992292
138KLF4_19829295_ChIP-Seq_ESCs_Human0.86772386
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.86628236
140AHR_22903824_ChIP-Seq_MCF-7_Human0.84605832
141RXR_22108803_ChIP-Seq_LS180_Human0.84552546
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84159053
143CBX2_27304074_Chip-Seq_ESCs_Mouse0.84119862
144* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83569470
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81610613
146SMC4_20622854_ChIP-Seq_HELA_Human0.81245254
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81145089
148TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80694288
149OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80454982
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80173258
151VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79754174
152LXR_22292898_ChIP-Seq_THP-1_Human0.78755699
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78495394
154OCT4_19829295_ChIP-Seq_ESCs_Human0.77838061
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77392862
156RNF2_27304074_Chip-Seq_NSC_Mouse0.77244387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.12557280
2MP0003880_abnormal_central_pattern4.55557653
3MP0003635_abnormal_synaptic_transmissio4.33280395
4MP0004270_analgesia3.80435555
5MP0009745_abnormal_behavioral_response3.47441649
6MP0002063_abnormal_learning/memory/cond3.32922833
7MP0009046_muscle_twitch3.31380672
8MP0002064_seizures3.28791790
9MP0005423_abnormal_somatic_nervous3.07350478
10MP0003303_peritoneal_inflammation3.04663462
11MP0001968_abnormal_touch/_nociception3.02703703
12MP0003436_decreased_susceptibility_to2.86457933
13MP0002822_catalepsy2.82405917
14MP0002734_abnormal_mechanical_nocicepti2.76243952
15MP0002572_abnormal_emotion/affect_behav2.72691434
16MP0002272_abnormal_nervous_system2.71629079
17MP0001486_abnormal_startle_reflex2.63254534
18MP0001501_abnormal_sleep_pattern2.31686805
19MP0002736_abnormal_nociception_after2.26715931
20MP0008569_lethality_at_weaning2.25208857
21MP0002735_abnormal_chemical_nociception2.21481239
22MP0003724_increased_susceptibility_to2.17457824
23MP0002733_abnormal_thermal_nociception2.13960219
24MP0001970_abnormal_pain_threshold2.08671430
25MP0001440_abnormal_grooming_behavior2.07790912
26MP0009780_abnormal_chondrocyte_physiolo2.02920958
27MP0004858_abnormal_nervous_system2.01526143
28MP0003329_amyloid_beta_deposits1.99347451
29MP0002909_abnormal_adrenal_gland1.95904322
30MP0002067_abnormal_sensory_capabilities1.95295308
31MP0008260_abnormal_autophagy1.94521724
32MP0004811_abnormal_neuron_physiology1.89326837
33MP0003191_abnormal_cellular_cholesterol1.85636505
34MP0009278_abnormal_bone_marrow1.84684942
35MP0002184_abnormal_innervation1.77899941
36MP0003705_abnormal_hypodermis_morpholog1.70996593
37MP0004885_abnormal_endolymph1.70316842
38MP0002419_abnormal_innate_immunity1.70269958
39MP0002557_abnormal_social/conspecific_i1.69740367
40MP0005386_behavior/neurological_phenoty1.66090532
41MP0004924_abnormal_behavior1.66090532
42MP0000955_abnormal_spinal_cord1.64621034
43MP0003183_abnormal_peptide_metabolism1.64494550
44MP0003879_abnormal_hair_cell1.57590135
45MP0000778_abnormal_nervous_system1.55911929
46MP0005646_abnormal_pituitary_gland1.54531655
47MP0003633_abnormal_nervous_system1.49581278
48MP0005451_abnormal_body_composition1.48760900
49MP0002066_abnormal_motor_capabilities/c1.46916774
50MP0006276_abnormal_autonomic_nervous1.42340564
51MP0002882_abnormal_neuron_morphology1.40969849
52MP0004142_abnormal_muscle_tone1.39021468
53MP0005025_abnormal_response_to1.38993582
54MP0003787_abnormal_imprinting1.36379799
55MP0005166_decreased_susceptibility_to1.30582798
56MP0004947_skin_inflammation1.26982803
57MP0001533_abnormal_skeleton_physiology1.26329190
58MP0005000_abnormal_immune_tolerance1.24890165
59MP0003631_nervous_system_phenotype1.23660888
60MP0001984_abnormal_olfaction1.22766847
61MP0001502_abnormal_circadian_rhythm1.20843709
62MP0005645_abnormal_hypothalamus_physiol1.20553225
63MP0003122_maternal_imprinting1.16153899
64MP0003690_abnormal_glial_cell1.13565908
65MP0003075_altered_response_to1.11795222
66MP0005464_abnormal_platelet_physiology1.11321663
67MP0004145_abnormal_muscle_electrophysio1.10061224
68MP0006082_CNS_inflammation1.09590395
69MP0009785_altered_susceptibility_to1.08897929
70MP0002148_abnormal_hypersensitivity_rea1.08365333
71MP0008872_abnormal_physiological_respon1.07560992
72MP0000678_abnormal_parathyroid_gland1.07378946
73MP0003283_abnormal_digestive_organ1.06901672
74MP0002653_abnormal_ependyma_morphology1.06352083
75MP0002152_abnormal_brain_morphology1.06017486
76MP0005058_abnormal_lysosome_morphology1.05984400
77MP0000751_myopathy1.05511325
78MP0008961_abnormal_basal_metabolism1.05308370
79MP0001905_abnormal_dopamine_level1.05141867
80MP0001348_abnormal_lacrimal_gland1.04436862
81MP0001790_abnormal_immune_system1.03450780
82MP0005387_immune_system_phenotype1.03450780
83MP0002229_neurodegeneration1.02767388
84MP0003045_fibrosis1.01804684
85MP0005409_darkened_coat_color1.00594513
86MP0000685_abnormal_immune_system1.00576085
87MP0003300_gastrointestinal_ulcer1.00029056
88MP0002723_abnormal_immune_serum0.99581443
89MP0000920_abnormal_myelination0.99313768
90MP0002420_abnormal_adaptive_immunity0.99157943
91MP0001819_abnormal_immune_cell0.98231399
92MP0003123_paternal_imprinting0.98178619
93MP0001177_atelectasis0.97282987
94MP0008874_decreased_physiological_sensi0.95324435
95MP0000013_abnormal_adipose_tissue0.94822433
96MP0000569_abnormal_digit_pigmentation0.93756006
97MP0002069_abnormal_eating/drinking_beha0.92725676
98MP0003634_abnormal_glial_cell0.92503064
99MP0005167_abnormal_blood-brain_barrier0.92479108
100MP0000604_amyloidosis0.91772804
101MP0003878_abnormal_ear_physiology0.91436605
102MP0005377_hearing/vestibular/ear_phenot0.91436605
103MP0004130_abnormal_muscle_cell0.90614561
104MP0003632_abnormal_nervous_system0.90204069
105MP0005535_abnormal_body_temperature0.88465861
106MP0001529_abnormal_vocalization0.87757747
107MP0002132_abnormal_respiratory_system0.86544005
108MP0002249_abnormal_larynx_morphology0.86248225
109MP0010386_abnormal_urinary_bladder0.85554287
110MP0001800_abnormal_humoral_immune0.83786624
111MP0001835_abnormal_antigen_presentation0.81863345
112MP0005076_abnormal_cell_differentiation0.80668739
113MP0004085_abnormal_heartbeat0.80664002
114MP0001851_eye_inflammation0.80374622
115MP0002452_abnormal_antigen_presenting0.80065379
116MP0004742_abnormal_vestibular_system0.77831458
117MP0003172_abnormal_lysosome_physiology0.77228959
118MP0005551_abnormal_eye_electrophysiolog0.74884349
119MP0004510_myositis0.73851089
120MP0001963_abnormal_hearing_physiology0.73344924
121MP0009764_decreased_sensitivity_to0.71673930
122MP0001545_abnormal_hematopoietic_system0.71344889
123MP0005397_hematopoietic_system_phenotyp0.71344889
124MP0003137_abnormal_impulse_conducting0.70853657
125MP0000858_altered_metastatic_potential0.69619275
126MP0002090_abnormal_vision0.69528776
127MP0005394_taste/olfaction_phenotype0.67251157
128MP0005499_abnormal_olfactory_system0.67251157
129MP0005671_abnormal_response_to0.67247881
130MP0005623_abnormal_meninges_morphology0.66981135
131MP0002998_abnormal_bone_remodeling0.66894095
132MP0002752_abnormal_somatic_nervous0.66471494
133MP0003866_abnormal_defecation0.65972521
134MP0000716_abnormal_immune_system0.65682412
135MP0004043_abnormal_pH_regulation0.65294979
136MP0004215_abnormal_myocardial_fiber0.65121929
137MP0001485_abnormal_pinna_reflex0.64814242
138MP0001188_hyperpigmentation0.63465357
139MP0004484_altered_response_of0.61816412
140MP0010234_abnormal_vibrissa_follicle0.61586351
141MP0004233_abnormal_muscle_weight0.60665147
142MP0001299_abnormal_eye_distance/0.60317042
143MP0002638_abnormal_pupillary_reflex0.56051019
144MP0000747_muscle_weakness0.54174344
145MP0001664_abnormal_digestion0.53937788
146MP0010769_abnormal_survival0.53889083
147MP0002837_dystrophic_cardiac_calcinosis0.53345355
148MP0000631_abnormal_neuroendocrine_gland0.52827731
149MP0001943_abnormal_respiration0.51687155
150MP0003956_abnormal_body_size0.50953657
151MP0002089_abnormal_postnatal_growth/wei0.50651626

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.73666296
2Focal motor seizures (HP:0011153)7.16766053
3Visual hallucinations (HP:0002367)5.79242160
4Focal seizures (HP:0007359)5.66533541
5Action tremor (HP:0002345)4.81616030
6Progressive cerebellar ataxia (HP:0002073)4.61853226
7Supranuclear gaze palsy (HP:0000605)4.35244466
8Atonic seizures (HP:0010819)4.33304718
9Epileptic encephalopathy (HP:0200134)4.21983208
10Febrile seizures (HP:0002373)4.14660426
11Ankle clonus (HP:0011448)4.04516196
12Absence seizures (HP:0002121)3.93523154
13Generalized tonic-clonic seizures (HP:0002069)3.81691326
14Eczematoid dermatitis (HP:0000976)3.62693841
15Depression (HP:0000716)3.61589362
16Dialeptic seizures (HP:0011146)3.55508447
17Impaired vibration sensation in the lower limbs (HP:0002166)3.50028860
18Poor eye contact (HP:0000817)3.44779393
19Papilledema (HP:0001085)3.43415492
20Postural instability (HP:0002172)3.41589858
21Mutism (HP:0002300)3.41548185
22Dysdiadochokinesis (HP:0002075)3.34022960
23Gaze-evoked nystagmus (HP:0000640)3.31885132
24Urinary bladder sphincter dysfunction (HP:0002839)3.28903023
25Abnormality of the lower motor neuron (HP:0002366)3.27844634
26Dysmetria (HP:0001310)3.26983149
27Ventricular fibrillation (HP:0001663)3.26837995
28Anxiety (HP:0000739)3.22624663
29Abnormal eating behavior (HP:0100738)3.19186707
30Impaired social interactions (HP:0000735)3.17573962
31Abnormal social behavior (HP:0012433)3.17573962
32Myositis (HP:0100614)3.16664304
33Broad-based gait (HP:0002136)3.16328884
34Orchitis (HP:0100796)3.15064041
35Hemiplegia (HP:0002301)3.05749658
36Intention tremor (HP:0002080)3.02339877
37Truncal ataxia (HP:0002078)3.00288692
38Abnormality of macrophages (HP:0004311)2.99140667
39Torticollis (HP:0000473)2.95166883
40Urinary urgency (HP:0000012)2.95065355
41Recurrent abscess formation (HP:0002722)2.93891056
42Recurrent gram-negative bacterial infections (HP:0005420)2.87588776
43Genetic anticipation (HP:0003743)2.85213851
44Impaired smooth pursuit (HP:0007772)2.84246956
45Annular pancreas (HP:0001734)2.81568445
46Hypochromic microcytic anemia (HP:0004840)2.81542982
47Spastic gait (HP:0002064)2.77118124
48Focal dystonia (HP:0004373)2.74232959
49Retrobulbar optic neuritis (HP:0100654)2.72555804
50Optic neuritis (HP:0100653)2.72555804
51Scanning speech (HP:0002168)2.71921613
52Hemiparesis (HP:0001269)2.71665245
53Recurrent bacterial skin infections (HP:0005406)2.67965182
54Slow saccadic eye movements (HP:0000514)2.67565877
55Obstructive lung disease (HP:0006536)2.66390421
56Chronic obstructive pulmonary disease (HP:0006510)2.66390421
57Bradykinesia (HP:0002067)2.61555034
58Amblyopia (HP:0000646)2.61542975
59Insomnia (HP:0100785)2.59354274
60Diplopia (HP:0000651)2.58247707
61Abnormality of binocular vision (HP:0011514)2.58247707
62Bundle branch block (HP:0011710)2.57232734
63Megalencephaly (HP:0001355)2.56528250
64Neurofibrillary tangles (HP:0002185)2.52179132
65Abnormality of ocular smooth pursuit (HP:0000617)2.51289733
66Hypochromic anemia (HP:0001931)2.49837526
67Progressive inability to walk (HP:0002505)2.49618129
68Dysmetric saccades (HP:0000641)2.45211459
69Stereotypic behavior (HP:0000733)2.44307559
70Segmental peripheral demyelination/remyelination (HP:0003481)2.44299686
71Diminished motivation (HP:0000745)2.44106667
72Status epilepticus (HP:0002133)2.44090175
73Craniofacial dystonia (HP:0012179)2.44032566
74Pointed chin (HP:0000307)2.43464815
75Cellulitis (HP:0100658)2.42551523
76Gastrointestinal infarctions (HP:0005244)2.39670449
77Amyloidosis (HP:0011034)2.37918079
78Cerebral inclusion bodies (HP:0100314)2.37887519
79Episodic fever (HP:0001954)2.35744105
80Mediastinal lymphadenopathy (HP:0100721)2.33148548
81Impaired vibratory sensation (HP:0002495)2.31568848
82Clonus (HP:0002169)2.30269557
83Lower limb muscle weakness (HP:0007340)2.28388960
84Stomatitis (HP:0010280)2.25210450
85Termporal pattern (HP:0011008)2.22589002
86Insidious onset (HP:0003587)2.22589002
87Pheochromocytoma (HP:0002666)2.20806158
88Agitation (HP:0000713)2.19236175
89Drooling (HP:0002307)2.16768361
90Excessive salivation (HP:0003781)2.16768361
91Polygenic inheritance (HP:0010982)2.16096680
92Abnormality of saccadic eye movements (HP:0000570)2.14613296
93Tetraplegia (HP:0002445)2.14434284
94Abnormality of the corticospinal tract (HP:0002492)2.13654717
95Cholecystitis (HP:0001082)2.13298780
96Abnormal gallbladder physiology (HP:0012438)2.13298780
97Decreased motor nerve conduction velocity (HP:0003431)2.12754767
98Fetal akinesia sequence (HP:0001989)2.10469622
99Increased IgE level (HP:0003212)2.09806042
100Increased cerebral lipofuscin (HP:0011813)2.09786160
101Hyperventilation (HP:0002883)2.07238562
102Neuronal loss in central nervous system (HP:0002529)2.07212226
103Limb dystonia (HP:0002451)2.06706955
104Onion bulb formation (HP:0003383)2.06366550
105Epileptiform EEG discharges (HP:0011182)2.05414124
106Obstructive sleep apnea (HP:0002870)2.04619523
107EEG with generalized epileptiform discharges (HP:0011198)2.03457861
108Upper limb amyotrophy (HP:0009129)2.01812180
109Distal upper limb amyotrophy (HP:0007149)2.01812180
110Gingivitis (HP:0000230)2.01090669
111Generalized myoclonic seizures (HP:0002123)2.01042214
112Abnormal EKG (HP:0003115)2.00344216
113Hypsarrhythmia (HP:0002521)1.99361343
114Lower limb asymmetry (HP:0100559)1.97735086
115Memory impairment (HP:0002354)1.97403590
116Amyotrophic lateral sclerosis (HP:0007354)1.96894796
117Elevated erythrocyte sedimentation rate (HP:0003565)1.96584497
118Rigidity (HP:0002063)1.95833986
119Incomplete penetrance (HP:0003829)1.95471619
120Gait ataxia (HP:0002066)1.95111017
121Rapidly progressive (HP:0003678)1.94764633
122Urticaria (HP:0001025)1.93013492
123Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91308008
124Apathy (HP:0000741)1.89222508
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89094178
126Psychosis (HP:0000709)1.88306084
127Delusions (HP:0000746)1.87611299
128Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86599978
129Resting tremor (HP:0002322)1.85678465
130Spinal canal stenosis (HP:0003416)1.85027647
131Dementia (HP:0000726)1.84854866
132Meningitis (HP:0001287)1.84367187
133Polyphagia (HP:0002591)1.84101818
134Hyperacusis (HP:0010780)1.83287204
135Loss of speech (HP:0002371)1.80888432
136Neuroendocrine neoplasm (HP:0100634)1.80878571
137Hand muscle atrophy (HP:0009130)1.79533503
138Prolonged bleeding time (HP:0003010)1.79214579
139Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79064363
140Bowel incontinence (HP:0002607)1.78691355
141Sleep apnea (HP:0010535)1.78532304
142Absent speech (HP:0001344)1.78473492
143Postural tremor (HP:0002174)1.78111124
144Distal sensory impairment (HP:0002936)1.77590571
145Lower limb amyotrophy (HP:0007210)1.77427734
146Peripheral hypomyelination (HP:0007182)1.75792676
147Hyperthyroidism (HP:0000836)1.75489118
148Abnormality of glycosphingolipid metabolism (HP:0004343)1.75360354
149Neoplasm of the peripheral nervous system (HP:0100007)1.74813017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.36285490
2MAP3K94.20900868
3EPHA43.88941578
4MINK12.95227153
5MAP3K42.85913140
6MARK12.83739939
7PRKD32.70360835
8PAK62.60121690
9DAPK22.51249956
10KSR22.38914564
11MAP3K112.33236402
12CAMKK12.32845265
13TRIB32.31564076
14ERN12.23933231
15MAP2K72.19798908
16NTRK12.08932476
17NTRK22.07694393
18MAP2K41.90522570
19MAP3K121.80283105
20IRAK41.72160034
21RIPK41.69382282
22SIK11.69245754
23MAP2K31.69199329
24CDK51.60679402
25SMG11.55823434
26GRK51.52259698
27UHMK11.36713990
28ARAF1.34802798
29KSR11.34289059
30CDK191.33817976
31MAP3K21.33169836
32DAPK11.32994233
33EPHB11.32419837
34MAP4K11.31098214
35TYRO31.28961555
36LMTK21.27898416
37PINK11.27130004
38TAOK21.26256286
39SIK21.24617166
40PRPF4B1.23474977
41FES1.22174008
42TAOK11.21038612
43PRKCG1.20399296
44IRAK31.19003293
45MAP3K31.18925086
46LATS21.18856206
47IRAK21.17512367
48CAMKK21.17412635
49TNIK1.16951613
50PHKG21.16831269
51PHKG11.16831269
52MAP3K131.14471712
53PLK21.14446259
54BLK1.14070867
55ALK1.13835092
56MAPK131.11226549
57SIK31.10452162
58PRKCH1.09794782
59CAMK11.09464714
60PRKD21.05233911
61CSK1.05059720
62GRK61.02381891
63STK111.01612344
64RIPK11.00933845
65RET0.97295600
66MAPK120.95788965
67CDK150.94468628
68CDK180.93280620
69TNK20.92813167
70PNCK0.92613107
71WNK10.92588475
72SGK4940.92351274
73SGK2230.92351274
74ICK0.90575276
75CDK140.88055873
76CDK11A0.83210386
77TYK20.82306304
78CAMK2A0.81333508
79PRKG20.78497548
80JAK20.78192860
81PAK30.77972595
82ZAP700.77776690
83SGK30.77426373
84PDK10.75853908
85NEK10.73865852
86MAP3K10.73350923
87BRSK10.72487673
88TBK10.71187772
89RAF10.70987221
90HCK0.70945902
91MARK20.70657175
92CDC42BPA0.70463975
93SGK20.69458335
94BRAF0.68290685
95* STK380.68028249
96PDPK10.67542746
97FGR0.65360315
98CAMK2B0.64841882
99HIPK20.64373074
100SGK10.62408179
101PTK60.60912181
102PTK2B0.59767583
103SCYL20.59045597
104DYRK1A0.57912791
105TESK10.56274499
106MAP3K70.56104443
107OXSR10.54967373
108RPS6KA30.54528068
109CAMK1G0.53475931
110CSNK1G20.53205789
111CAMK40.52748393
112JAK10.51759106
113MAPK100.50539175
114NEK60.50255009
115MAP2K60.49985985
116CAMK2G0.49786180
117PRKCZ0.49668488
118SYK0.48848274
119DYRK1B0.47929471
120FYN0.47661924
121CASK0.46562051
122FER0.43254282
123BMPR20.40484473
124CAMK2D0.40273134
125DAPK30.39318960
126BMX0.38964358
127MAP2K10.36649712
128RPS6KA20.36094046
129PRKCE0.35424050
130ROCK20.33813371
131PRKCB0.31864306
132MAPKAPK50.28587491
133DDR20.28411567
134PRKCA0.28401927
135LIMK10.27936761
136ROCK10.27818073

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.43284896
2Synaptic vesicle cycle_Homo sapiens_hsa047213.37863086
3Olfactory transduction_Homo sapiens_hsa047402.80772416
4GABAergic synapse_Homo sapiens_hsa047272.68103699
5Circadian entrainment_Homo sapiens_hsa047132.64510488
6Long-term potentiation_Homo sapiens_hsa047202.60300217
7Glutamatergic synapse_Homo sapiens_hsa047242.53552974
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.49185012
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47292903
10Morphine addiction_Homo sapiens_hsa050322.36120687
11Amphetamine addiction_Homo sapiens_hsa050312.32665809
12Salivary secretion_Homo sapiens_hsa049702.19461026
13Insulin secretion_Homo sapiens_hsa049112.08393496
14Dopaminergic synapse_Homo sapiens_hsa047282.07136399
15Gastric acid secretion_Homo sapiens_hsa049712.03539882
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90811431
17Cholinergic synapse_Homo sapiens_hsa047251.89780284
18Nitrogen metabolism_Homo sapiens_hsa009101.85702155
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78072661
20Osteoclast differentiation_Homo sapiens_hsa043801.66124589
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63630141
22Taste transduction_Homo sapiens_hsa047421.62502581
23Long-term depression_Homo sapiens_hsa047301.62425840
24Oxytocin signaling pathway_Homo sapiens_hsa049211.61629417
25Cocaine addiction_Homo sapiens_hsa050301.55477782
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55246242
27Renin secretion_Homo sapiens_hsa049241.53936630
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50354071
29Calcium signaling pathway_Homo sapiens_hsa040201.50271515
30GnRH signaling pathway_Homo sapiens_hsa049121.49747941
31Serotonergic synapse_Homo sapiens_hsa047261.39848827
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34254604
33Gap junction_Homo sapiens_hsa045401.31744562
34Leishmaniasis_Homo sapiens_hsa051401.30232131
35Type II diabetes mellitus_Homo sapiens_hsa049301.29409220
36cAMP signaling pathway_Homo sapiens_hsa040241.28537455
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28366022
38Tuberculosis_Homo sapiens_hsa051521.28024153
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25646870
40B cell receptor signaling pathway_Homo sapiens_hsa046621.25195483
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20628247
42Acute myeloid leukemia_Homo sapiens_hsa052211.19839919
43Estrogen signaling pathway_Homo sapiens_hsa049151.19836917
44Glioma_Homo sapiens_hsa052141.18218115
45Collecting duct acid secretion_Homo sapiens_hsa049661.07998570
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06917988
47African trypanosomiasis_Homo sapiens_hsa051431.06582317
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03482198
49Melanogenesis_Homo sapiens_hsa049161.01008320
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00313622
51ErbB signaling pathway_Homo sapiens_hsa040120.99277420
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99218243
53Cardiac muscle contraction_Homo sapiens_hsa042600.96456817
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.93283545
55Axon guidance_Homo sapiens_hsa043600.93181545
56Pancreatic secretion_Homo sapiens_hsa049720.93043932
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92359923
58Staphylococcus aureus infection_Homo sapiens_hsa051500.91313847
59Oocyte meiosis_Homo sapiens_hsa041140.90760194
60Dorso-ventral axis formation_Homo sapiens_hsa043200.90060357
61Thyroid hormone synthesis_Homo sapiens_hsa049180.87896432
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.87335093
63Chronic myeloid leukemia_Homo sapiens_hsa052200.87003193
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82521788
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82152769
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79720689
67Salmonella infection_Homo sapiens_hsa051320.78555617
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77864584
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77084277
70Notch signaling pathway_Homo sapiens_hsa043300.75787943
71TNF signaling pathway_Homo sapiens_hsa046680.74644362
72Vitamin B6 metabolism_Homo sapiens_hsa007500.73886709
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73654939
74Dilated cardiomyopathy_Homo sapiens_hsa054140.73539454
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.73411925
76Bile secretion_Homo sapiens_hsa049760.72235958
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.70682719
78Malaria_Homo sapiens_hsa051440.70480079
79Choline metabolism in cancer_Homo sapiens_hsa052310.70350287
80Prolactin signaling pathway_Homo sapiens_hsa049170.69469741
81Vibrio cholerae infection_Homo sapiens_hsa051100.68944503
82Hepatitis C_Homo sapiens_hsa051600.68461551
83MAPK signaling pathway_Homo sapiens_hsa040100.68068163
84Phagosome_Homo sapiens_hsa041450.66612466
85Amoebiasis_Homo sapiens_hsa051460.65006503
86VEGF signaling pathway_Homo sapiens_hsa043700.64855259
87T cell receptor signaling pathway_Homo sapiens_hsa046600.62883435
88Phototransduction_Homo sapiens_hsa047440.62426959
89Endocytosis_Homo sapiens_hsa041440.62110954
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61666822
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61457099
92Glucagon signaling pathway_Homo sapiens_hsa049220.60794317
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60089120
94Toxoplasmosis_Homo sapiens_hsa051450.59396693
95Pancreatic cancer_Homo sapiens_hsa052120.58749513
96mTOR signaling pathway_Homo sapiens_hsa041500.58351875
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56622239
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.56453013
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.56370635
100Pertussis_Homo sapiens_hsa051330.56362144
101Rap1 signaling pathway_Homo sapiens_hsa040150.55316026
102Inositol phosphate metabolism_Homo sapiens_hsa005620.54837134
103HIF-1 signaling pathway_Homo sapiens_hsa040660.54657492
104Platelet activation_Homo sapiens_hsa046110.53371764
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53104451
106Type I diabetes mellitus_Homo sapiens_hsa049400.52946120
107Ras signaling pathway_Homo sapiens_hsa040140.52845098
108Non-small cell lung cancer_Homo sapiens_hsa052230.47271012
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45994899
110Prion diseases_Homo sapiens_hsa050200.45497021
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45026887
112Endometrial cancer_Homo sapiens_hsa052130.44803467
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44655453
114Alcoholism_Homo sapiens_hsa050340.44439395
115Insulin signaling pathway_Homo sapiens_hsa049100.44237187
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42654382
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40569965
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40231231
119Renal cell carcinoma_Homo sapiens_hsa052110.38862416
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37719109
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37359916
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37194029
123Circadian rhythm_Homo sapiens_hsa047100.36840916
124Chemokine signaling pathway_Homo sapiens_hsa040620.35542427
125Ovarian steroidogenesis_Homo sapiens_hsa049130.34719991
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33051373
127Wnt signaling pathway_Homo sapiens_hsa043100.32649192
128Arginine biosynthesis_Homo sapiens_hsa002200.32183884
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31262859
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30666293
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.27680688
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27213694

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