PANX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to ethanol (GO:0048149)9.73266510
2adult feeding behavior (GO:0008343)9.38826272
3regulation of translational termination (GO:0006449)9.09347778
4negative regulation of calcium ion-dependent exocytosis (GO:0045955)8.91487255
5sphingomyelin metabolic process (GO:0006684)8.44477428
6notochord development (GO:0030903)8.32629211
7limb bud formation (GO:0060174)8.27746698
8positive regulation of extracellular matrix organization (GO:1903055)7.91203707
9phospholipid efflux (GO:0033700)7.79642705
10regulation of protein glycosylation (GO:0060049)7.79152800
11negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)7.78997211
12adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)7.77971974
13regulation of acrosome reaction (GO:0060046)7.52417497
14collagen fibril organization (GO:0030199)7.28368678
15positive regulation of cAMP-mediated signaling (GO:0043950)6.66190235
16high-density lipoprotein particle remodeling (GO:0034375)6.62124499
17cartilage development (GO:0051216)6.49968983
18negative regulation of nitric oxide biosynthetic process (GO:0045019)6.35278145
19sphingosine metabolic process (GO:0006670)6.29955448
20replacement ossification (GO:0036075)6.25544604
21endochondral ossification (GO:0001958)6.25544604
22proteoglycan metabolic process (GO:0006029)6.22568108
23piRNA metabolic process (GO:0034587)6.21426175
24regulation of triglyceride catabolic process (GO:0010896)6.13056171
25chondroitin sulfate biosynthetic process (GO:0030206)5.97523901
26embryonic skeletal joint morphogenesis (GO:0060272)5.86136039
27glycerol ether metabolic process (GO:0006662)5.73044870
28nucleotide-sugar biosynthetic process (GO:0009226)5.70795474
29negative regulation of gluconeogenesis (GO:0045721)5.69260963
30diol metabolic process (GO:0034311)5.67654524
31thrombin receptor signaling pathway (GO:0070493)5.62463669
32protein retention in ER lumen (GO:0006621)5.53316239
33reverse cholesterol transport (GO:0043691)5.53095004
34regulation of extracellular matrix disassembly (GO:0010715)5.51287591
35negative regulation of fatty acid biosynthetic process (GO:0045717)5.42307007
36chondrocyte differentiation (GO:0002062)5.41954254
37ether metabolic process (GO:0018904)5.27962249
38cellular glucuronidation (GO:0052695)5.26544271
39sphingoid metabolic process (GO:0046519)5.25920320
40positive regulation of chondrocyte differentiation (GO:0032332)5.21663006
41response to gravity (GO:0009629)5.15309903
42lipopolysaccharide biosynthetic process (GO:0009103)5.11349195
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.09459934
44skeletal system development (GO:0001501)5.08858967
45keratan sulfate biosynthetic process (GO:0018146)5.07545544
46collagen catabolic process (GO:0030574)4.93697816
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.85932881
48regulation of extracellular matrix organization (GO:1903053)4.83940199
49negative regulation of glycoprotein biosynthetic process (GO:0010561)4.78886557
50glucuronate metabolic process (GO:0019585)4.78744294
51uronic acid metabolic process (GO:0006063)4.78744294
52regulation of glutamate receptor signaling pathway (GO:1900449)4.76937093
53cellular response to ammonium ion (GO:0071242)4.69998882
54positive regulation of cartilage development (GO:0061036)4.68310808
55collagen metabolic process (GO:0032963)4.65200403
56endothelial cell morphogenesis (GO:0001886)4.62461487
57regulation of plasminogen activation (GO:0010755)4.62290991
58regulation of cAMP-mediated signaling (GO:0043949)4.61234523
59short-term memory (GO:0007614)4.57164468
60very-low-density lipoprotein particle assembly (GO:0034379)4.54134412
61signal complex assembly (GO:0007172)4.52503864
62multicellular organismal catabolic process (GO:0044243)4.52102338
63iron ion import (GO:0097286)4.50631079
64plasma lipoprotein particle assembly (GO:0034377)4.46976606
65myelin assembly (GO:0032288)4.45741662
66DNA replication-dependent nucleosome assembly (GO:0006335)4.44565854
67DNA replication-dependent nucleosome organization (GO:0034723)4.44565854
68hypotonic response (GO:0006971)4.42999836
69plasma lipoprotein particle clearance (GO:0034381)4.40010399
70mRNA cleavage (GO:0006379)4.39027730
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.37565687
72multicellular organismal macromolecule metabolic process (GO:0044259)4.34430958
73lipopolysaccharide metabolic process (GO:0008653)4.33101582
74peptidyl-proline hydroxylation (GO:0019511)4.32165703
75connective tissue development (GO:0061448)4.25678218
76cellular response to BMP stimulus (GO:0071773)4.21443479
77response to BMP (GO:0071772)4.21443479
78pyrimidine dimer repair (GO:0006290)4.21176152
79multicellular organismal metabolic process (GO:0044236)4.13134063
80endocardial cushion morphogenesis (GO:0003203)4.13062103
81keratan sulfate metabolic process (GO:0042339)4.11782315
82regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.04325422
83fat-soluble vitamin catabolic process (GO:0042363)4.04017474
84vitamin catabolic process (GO:0009111)4.04017474
85regulation of translational elongation (GO:0006448)3.99845854
86ncRNA catabolic process (GO:0034661)3.98200936
87glycoprotein metabolic process (GO:0009100)3.97674535
88protein-lipid complex remodeling (GO:0034368)3.92993653
89macromolecular complex remodeling (GO:0034367)3.92993653
90plasma lipoprotein particle remodeling (GO:0034369)3.92993653
91protein-lipid complex assembly (GO:0065005)3.88077885
92negative regulation of smooth muscle cell differentiation (GO:0051151)3.80272729
93negative regulation of chemokine production (GO:0032682)3.76834524
94extracellular matrix disassembly (GO:0022617)3.73451397
95positive regulation of hormone biosynthetic process (GO:0046886)3.71747294
96cellular response to alkaloid (GO:0071312)3.70055607
97glycosaminoglycan biosynthetic process (GO:0006024)3.68961191
98ovulation from ovarian follicle (GO:0001542)3.65928862
99embryonic viscerocranium morphogenesis (GO:0048703)3.64875627
100regulation of chondrocyte differentiation (GO:0032330)3.64586038
101aminoglycan biosynthetic process (GO:0006023)3.63616742
102glycosphingolipid metabolic process (GO:0006687)3.59865326
103UDP-N-acetylglucosamine metabolic process (GO:0006047)3.58774099
104regulation of female receptivity (GO:0045924)3.57532865
105regulation of cartilage development (GO:0061035)3.57211485
106COPII vesicle coating (GO:0048208)3.54780335
107regulation of steroid hormone biosynthetic process (GO:0090030)3.54138639
108chondrocyte proliferation (GO:0035988)3.53911814
109neurotransmitter catabolic process (GO:0042135)3.53437322
110regulation of response to osmotic stress (GO:0047484)3.51863556
111detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51560339
112chondroitin sulfate metabolic process (GO:0030204)3.50931335
113negative regulation of cell-matrix adhesion (GO:0001953)3.50436150
114ossification (GO:0001503)3.49153153
115coenzyme catabolic process (GO:0009109)3.44015237
116negative regulation of glycoprotein metabolic process (GO:1903019)3.41886292
117bone development (GO:0060348)3.37379153
118sulfur compound catabolic process (GO:0044273)3.37266482
119negative regulation of NF-kappaB import into nucleus (GO:0042347)3.34659282
120hyperosmotic salinity response (GO:0042538)3.34371152
121regulation of type B pancreatic cell apoptotic process (GO:2000674)3.31574778
122negative regulation of adenylate cyclase activity (GO:0007194)3.30652968
123regulation of bone mineralization (GO:0030500)3.30267520
124regulation of cholesterol esterification (GO:0010872)3.30206007
125uterus development (GO:0060065)3.28565359
126mesenchyme morphogenesis (GO:0072132)3.26955922
127protein hydroxylation (GO:0018126)3.25804106
128female mating behavior (GO:0060180)3.25451157
129positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.22679007
130glycosaminoglycan catabolic process (GO:0006027)3.22550376
131nucleotide-sugar metabolic process (GO:0009225)3.22122730
132response to morphine (GO:0043278)3.21956889
133skin morphogenesis (GO:0043589)3.18423577
134triglyceride catabolic process (GO:0019433)3.17332655
135COPI coating of Golgi vesicle (GO:0048205)3.15084717
136Golgi transport vesicle coating (GO:0048200)3.15084717
137extracellular matrix organization (GO:0030198)3.14904597
138regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.13904236
139extracellular structure organization (GO:0043062)3.13886555
140negative regulation of cyclase activity (GO:0031280)3.12850313
141negative regulation of cartilage development (GO:0061037)3.10312544
142neutral lipid catabolic process (GO:0046461)3.09432935
143acylglycerol catabolic process (GO:0046464)3.09432935
144cholesterol efflux (GO:0033344)3.08108463
145detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.06841722
146plasma lipoprotein particle organization (GO:0071827)3.06805352
147regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.06779319
148aminoglycan catabolic process (GO:0006026)3.06202002
149positive regulation of neurological system process (GO:0031646)3.05870882
150cornea development in camera-type eye (GO:0061303)3.05264323
151response to isoquinoline alkaloid (GO:0014072)3.04980675
152thyroid hormone generation (GO:0006590)3.04830012
153endodermal cell differentiation (GO:0035987)3.04541737
154sphingolipid catabolic process (GO:0030149)3.04119745
155proteoglycan biosynthetic process (GO:0030166)3.00848462
156negative regulation of lyase activity (GO:0051350)3.00629635
157limb development (GO:0060173)2.99060111
158appendage development (GO:0048736)2.99060111
159regulation of biomineral tissue development (GO:0070167)2.98966373
160glomerular visceral epithelial cell development (GO:0072015)2.97373493
161cell-cell junction maintenance (GO:0045217)2.96045756
162chemical homeostasis within a tissue (GO:0048875)2.95201277
163N-terminal protein amino acid acetylation (GO:0006474)2.93433885
164negative regulation of fatty acid metabolic process (GO:0045922)2.92953542
165regulation of cell maturation (GO:1903429)2.92469405
166regulation of triglyceride metabolic process (GO:0090207)2.90236255
167glycolipid metabolic process (GO:0006664)2.89507002
168negative regulation of lipase activity (GO:0060192)2.88267154
169regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.87998724
170positive regulation of icosanoid secretion (GO:0032305)2.86214055
171glycine transport (GO:0015816)2.83714847
172DNA synthesis involved in DNA repair (GO:0000731)2.83540352
173bone mineralization (GO:0030282)2.83263072
174protein-lipid complex subunit organization (GO:0071825)2.83174004
175regulation of hormone biosynthetic process (GO:0046885)2.83126133
176positive regulation of fatty acid transport (GO:2000193)2.80186989
177negative regulation of exocytosis (GO:0045920)2.78802442
178sensory perception of pain (GO:0019233)2.78676817
179positive regulation of nitric oxide biosynthetic process (GO:0045429)2.72849002
180membrane lipid metabolic process (GO:0006643)2.72846085
181liposaccharide metabolic process (GO:1903509)2.71294574
182omega-hydroxylase P450 pathway (GO:0097267)2.70053241
183thyroid hormone metabolic process (GO:0042403)2.69061855
184neuronal action potential (GO:0019228)2.67484016
185left/right axis specification (GO:0070986)2.66715897
186GMP metabolic process (GO:0046037)2.66450868
187regulation of odontogenesis (GO:0042481)2.64315096
188cellular response to ATP (GO:0071318)2.64254129
189resolution of meiotic recombination intermediates (GO:0000712)2.63686997
190regulation of memory T cell differentiation (GO:0043380)2.63453106
191negative regulation of cytosolic calcium ion concentration (GO:0051481)14.0618231
192cartilage development involved in endochondral bone morphogenesis (GO:0060351)13.9622541
193negative regulation of cAMP-mediated signaling (GO:0043951)12.4575957
194cell aggregation (GO:0098743)12.1835182
195cartilage condensation (GO:0001502)12.1835182
196chondrocyte development (GO:0002063)11.1902434
197keratan sulfate catabolic process (GO:0042340)10.8716925
198opioid receptor signaling pathway (GO:0038003)10.4331039
199ether lipid metabolic process (GO:0046485)10.2302556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human9.15883024
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.42198842
3AR_21572438_ChIP-Seq_LNCaP_Human5.21936670
4VDR_22108803_ChIP-Seq_LS180_Human5.08320676
5GATA1_22025678_ChIP-Seq_K562_Human4.44890452
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.97587403
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.73062400
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.67021881
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.64903749
10ESR1_21235772_ChIP-Seq_MCF-7_Human3.64627022
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.37058938
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.20833104
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01832863
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69124354
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.55609518
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50661695
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.44244559
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.42274031
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32242010
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.26897856
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.18118655
22HTT_18923047_ChIP-ChIP_STHdh_Human2.16912925
23TAF15_26573619_Chip-Seq_HEK293_Human2.16440699
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.12126657
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.07735895
26CJUN_26792858_Chip-Seq_BT549_Human2.03454314
27ZNF274_21170338_ChIP-Seq_K562_Hela2.00621547
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99403529
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.98630961
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93649126
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.90453526
32BCAT_22108803_ChIP-Seq_LS180_Human1.88319856
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.80691067
34* NANOG_20526341_ChIP-Seq_ESCs_Human1.78749361
35CBP_20019798_ChIP-Seq_JUKART_Human1.75085991
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.75085991
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74237746
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.73175798
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68149944
40* SOX2_19829295_ChIP-Seq_ESCs_Human1.67748940
41* NANOG_19829295_ChIP-Seq_ESCs_Human1.67748940
42DROSHA_22980978_ChIP-Seq_HELA_Human1.65192433
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63711857
44CEBPB_22108803_ChIP-Seq_LS180_Human1.62910582
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.61155721
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56718133
47TCF4_23295773_ChIP-Seq_U87_Human1.56358518
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.54647424
49IRF1_19129219_ChIP-ChIP_H3396_Human1.53050895
50* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49172970
51FOXH1_21741376_ChIP-Seq_ESCs_Human1.49070270
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46983930
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.45565155
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45350084
55STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.44187079
56RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.42558350
57EZH2_22144423_ChIP-Seq_EOC_Human1.42500805
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.41930705
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41567852
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41342689
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41019777
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41019777
63TP53_18474530_ChIP-ChIP_U2OS_Human1.40068400
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38716385
65CLOCK_20551151_ChIP-Seq_293T_Human1.38398208
66SOX2_20726797_ChIP-Seq_SW620_Human1.37401549
67SCL_19346495_ChIP-Seq_HPC-7_Human1.37310097
68GBX2_23144817_ChIP-Seq_PC3_Human1.37129465
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.36966699
70TP53_22573176_ChIP-Seq_HFKS_Human1.35488419
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35468973
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35105836
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32640716
74RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32640716
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31200538
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30311829
77STAT3_23295773_ChIP-Seq_U87_Human1.28302814
78RAC3_21632823_ChIP-Seq_H3396_Human1.27838525
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26495505
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26475049
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26282173
82CDX2_22108803_ChIP-Seq_LS180_Human1.24958020
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.23998590
84GATA3_24758297_ChIP-Seq_MCF-7_Human1.23597042
85VDR_24787735_ChIP-Seq_THP-1_Human1.23039445
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22500095
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22181273
88JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20574452
89E2F7_22180533_ChIP-Seq_HELA_Human1.18666305
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.18608369
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17982134
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17565099
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17498229
94SA1_22415368_ChIP-Seq_MEFs_Mouse1.17314474
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16859409
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16795497
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.16543890
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16226470
99E2F1_20622854_ChIP-Seq_HELA_Human1.16206885
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14753504
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14382650
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12274439
103GATA3_21867929_ChIP-Seq_TH1_Mouse1.10013071
104OCT4_20526341_ChIP-Seq_ESCs_Human1.08239132
105SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07824379
106OCT4_19829295_ChIP-Seq_ESCs_Human1.07695505
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07472925
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.07060513
109BRD4_25478319_ChIP-Seq_HGPS_Human1.06901896
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06573604
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06540064
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04955495
113IGF1R_20145208_ChIP-Seq_DFB_Human1.04816505
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04358521
115SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04115184
116SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04009456
117PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02696197
118REST_21632747_ChIP-Seq_MESCs_Mouse1.02500795
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02033400
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02002909
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01965866
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01671146
123CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01312881
124TP53_16413492_ChIP-PET_HCT116_Human1.01237190
125GATA1_19941826_ChIP-Seq_K562_Human1.01231966
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01172540
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00503806
128ERA_21632823_ChIP-Seq_H3396_Human0.99868256
129RUNX_20019798_ChIP-Seq_JUKART_Human0.99750805
130CTCF_21964334_Chip-Seq_Bcells_Human0.99446060
131TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99171358
132P53_21459846_ChIP-Seq_SAOS-2_Human0.99068778
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98125021
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97885077
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.97799969
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97353974
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97353974
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96710007
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96657392
140RNF2_27304074_Chip-Seq_ESCs_Mouse0.96459437
141HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96055687
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95336919
143TAF2_19829295_ChIP-Seq_ESCs_Human0.94788243
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.94093211
145FOXA2_19822575_ChIP-Seq_HepG2_Human0.92997270
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92673999
147BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92665199
148MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92512275
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.92453266
150SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92438549
151* OCT1_27270436_Chip-Seq_PROSTATE_Human0.92385423
152* RXR_22108803_ChIP-Seq_LS180_Human0.91646455
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.91123427
154SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91022806
155POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90383331
156OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90014307
157TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.89754503
158KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89535713
159PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89517275
160TCF4_22108803_ChIP-Seq_LS180_Human0.89326669
161TBX20_22080862_ChIP-Seq_HEART_Mouse0.89233578
162TBX20_22328084_ChIP-Seq_HEART_Mouse0.89233578
163RUNX2_22187159_ChIP-Seq_PCA_Human0.89174840
164TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88669699
165ERG_21242973_ChIP-ChIP_JURKAT_Human0.86041041
166NANOG_18555785_Chip-Seq_ESCs_Mouse0.85019998
167ELF5_23300383_ChIP-Seq_T47D_Human0.84714104
168P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84712746
169NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84460700
170* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84019317
171* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84019317
172MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81930826
173PIAS1_25552417_ChIP-Seq_VCAP_Human0.81680932
174CRX_20693478_ChIP-Seq_RETINA_Mouse0.81654087
175NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80388367
176GF1_26923725_Chip-Seq_HPCs_Mouse0.80308703
177CSB_26484114_Chip-Seq_FIBROBLAST_Human0.79959721
178NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79476335
179ESR1_20079471_ChIP-ChIP_T-47D_Human0.78579543
180WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78377791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.86281912
2MP0002933_joint_inflammation6.00318877
3MP0004134_abnormal_chest_morphology5.83951197
4MP0002876_abnormal_thyroid_physiology5.80133501
5MP0009278_abnormal_bone_marrow5.60624549
6MP0003646_muscle_fatigue5.13797873
7MP0009840_abnormal_foam_cell5.10354067
8MP0002282_abnormal_trachea_morphology5.07341889
9MP0005503_abnormal_tendon_morphology4.84808592
10MP0009250_abnormal_appendicular_skeleto4.26966139
11MP0000163_abnormal_cartilage_morphology4.24452261
12MP0009780_abnormal_chondrocyte_physiolo3.68022408
13MP0000678_abnormal_parathyroid_gland3.58557473
14MP0002115_abnormal_skeleton_extremities3.50073539
15MP0001968_abnormal_touch/_nociception3.32586823
16MP0003123_paternal_imprinting3.20896408
17MP0002909_abnormal_adrenal_gland3.10206235
18MP0003880_abnormal_central_pattern3.04180438
19MP0002113_abnormal_skeleton_development2.88670025
20MP0002896_abnormal_bone_mineralization2.87681639
21MP0003283_abnormal_digestive_organ2.87184037
22MP0002089_abnormal_postnatal_growth/wei2.72028671
23MP0000681_abnormal_thyroid_gland2.57493015
24MP0001542_abnormal_bone_strength2.57342735
25MP0001533_abnormal_skeleton_physiology2.40109218
26MP0000762_abnormal_tongue_morphology2.39307329
27MP0001299_abnormal_eye_distance/2.34581691
28MP0005508_abnormal_skeleton_morphology2.33812369
29MP0005390_skeleton_phenotype2.33034883
30MP0001545_abnormal_hematopoietic_system2.32844178
31MP0005397_hematopoietic_system_phenotyp2.32844178
32MP0001270_distended_abdomen2.30016054
33MP0003787_abnormal_imprinting2.25820652
34MP0002109_abnormal_limb_morphology2.24286408
35MP0002163_abnormal_gland_morphology2.20925557
36MP0000751_myopathy2.20106352
37MP0003656_abnormal_erythrocyte_physiolo2.12138646
38MP0006035_abnormal_mitochondrial_morpho2.09578555
39MP0005551_abnormal_eye_electrophysiolog2.08282197
40MP0003191_abnormal_cellular_cholesterol2.06252989
41MP0009764_decreased_sensitivity_to2.04697268
42MP0001501_abnormal_sleep_pattern1.98016792
43MP0003795_abnormal_bone_structure1.94879071
44MP0009333_abnormal_splenocyte_physiolog1.89912037
45MP0001664_abnormal_digestion1.80052757
46MP0003879_abnormal_hair_cell1.78125713
47MP0009384_cardiac_valve_regurgitation1.73312429
48MP0002116_abnormal_craniofacial_bone1.60671095
49MP0000049_abnormal_middle_ear1.50958253
50MP0004858_abnormal_nervous_system1.50696900
51MP0005645_abnormal_hypothalamus_physiol1.48379996
52MP0003638_abnormal_response/metabolism_1.47698097
53MP0003045_fibrosis1.46582909
54MP0008438_abnormal_cutaneous_collagen1.46064705
55MP0003959_abnormal_lean_body1.45816372
56MP0003755_abnormal_palate_morphology1.45636756
57MP0002108_abnormal_muscle_morphology1.43790936
58MP0004147_increased_porphyrin_level1.41161620
59MP0003633_abnormal_nervous_system1.40036529
60MP0003183_abnormal_peptide_metabolism1.37543340
61MP0002998_abnormal_bone_remodeling1.31560226
62MP0006292_abnormal_olfactory_placode1.27580878
63MP0010329_abnormal_lipoprotein_level1.24493741
64MP0000432_abnormal_head_morphology1.23655988
65MP0002971_abnormal_brown_adipose1.20505739
66MP0003567_abnormal_fetal_cardiomyocyte1.19703338
67MP0008995_early_reproductive_senescence1.19576947
68MP0005275_abnormal_skin_tensile1.18172036
69MP0005381_digestive/alimentary_phenotyp1.18026833
70MP0000343_altered_response_to1.17198845
71MP0004272_abnormal_basement_membrane1.17114092
72MP0002796_impaired_skin_barrier1.16283039
73MP0001663_abnormal_digestive_system1.15128201
74MP0003121_genomic_imprinting1.13530864
75MP0005083_abnormal_biliary_tract1.12948966
76MP0002111_abnormal_tail_morphology1.12480242
77MP0004019_abnormal_vitamin_homeostasis1.11925328
78MP0001881_abnormal_mammary_gland1.11497081
79MP0002233_abnormal_nose_morphology1.11135221
80MP0004233_abnormal_muscle_weight1.10657966
81MP0005379_endocrine/exocrine_gland_phen1.09772978
82MP0008004_abnormal_stomach_pH1.07462749
83MP0002114_abnormal_axial_skeleton1.07160611
84MP0003436_decreased_susceptibility_to1.06595361
85MP0002733_abnormal_thermal_nociception1.05948861
86MP0005670_abnormal_white_adipose1.04685960
87MP0004270_analgesia1.04283115
88MP0002272_abnormal_nervous_system1.01908131
89MP0002249_abnormal_larynx_morphology1.01460866
90MP0003935_abnormal_craniofacial_develop1.00556925
91MP0004197_abnormal_fetal_growth/weight/0.99647436
92MP0003279_aneurysm0.96623529
93MP0003136_yellow_coat_color0.96184158
94MP0004264_abnormal_extraembryonic_tissu0.95840957
95MP0001919_abnormal_reproductive_system0.93476465
96MP0009046_muscle_twitch0.93391566
97MP0004484_altered_response_of0.91208785
98MP0008057_abnormal_DNA_replication0.90411210
99MP0009745_abnormal_behavioral_response0.89844182
100MP0009697_abnormal_copulation0.89240991
101MP0003937_abnormal_limbs/digits/tail_de0.89099850
102MP0002693_abnormal_pancreas_physiology0.88334992
103MP0003566_abnormal_cell_adhesion0.87732527
104MP0005023_abnormal_wound_healing0.86330662
105MP0000015_abnormal_ear_pigmentation0.85363633
106MP0001963_abnormal_hearing_physiology0.85014113
107MP0002557_abnormal_social/conspecific_i0.83630019
108MP0002139_abnormal_hepatobiliary_system0.83023917
109MP0003385_abnormal_body_wall0.81789353
110MP0004084_abnormal_cardiac_muscle0.80519087
111MP0003122_maternal_imprinting0.80484994
112MP0005164_abnormal_response_to0.80190029
113MP0003631_nervous_system_phenotype0.79438530
114MP0004782_abnormal_surfactant_physiolog0.79134929
115MP0000462_abnormal_digestive_system0.78234020
116MP0005332_abnormal_amino_acid0.76717326
117MP0003950_abnormal_plasma_membrane0.75856353
118MP0005377_hearing/vestibular/ear_phenot0.75377156
119MP0003878_abnormal_ear_physiology0.75377156
120MP0003195_calcinosis0.74845447
121MP0005334_abnormal_fat_pad0.73925717
122MP0000358_abnormal_cell_content/0.73450215
123MP0002932_abnormal_joint_morphology0.72640278
124MP0003705_abnormal_hypodermis_morpholog0.72288118
125MP0005389_reproductive_system_phenotype0.71875098
126MP0009765_abnormal_xenobiotic_induced0.71614954
127MP0006072_abnormal_retinal_apoptosis0.71432231
128MP0009643_abnormal_urine_homeostasis0.70863550
129MP0008872_abnormal_physiological_respon0.69241059
130MP0003942_abnormal_urinary_system0.68996583
131MP0004185_abnormal_adipocyte_glucose0.68384307
132MP0003806_abnormal_nucleotide_metabolis0.67932260
133MP0003936_abnormal_reproductive_system0.67682758
134MP0000538_abnormal_urinary_bladder0.67358482
135MP0001970_abnormal_pain_threshold0.64335008
136MP0003938_abnormal_ear_development0.63971922
137MP0005167_abnormal_blood-brain_barrier0.62887019
138MP0003718_maternal_effect0.62789020
139MP0004085_abnormal_heartbeat0.60729038
140MP0003091_abnormal_cell_migration0.60482294
141MP0000465_gastrointestinal_hemorrhage0.59807733
142MP0002229_neurodegeneration0.59752156
143MP0001485_abnormal_pinna_reflex0.59338006
144MP0001943_abnormal_respiration0.59060760
145MP0005310_abnormal_salivary_gland0.58960156
146MP0008875_abnormal_xenobiotic_pharmacok0.58579500
147MP0005195_abnormal_posterior_eye0.58222368
148MP0002168_other_aberrant_phenotype0.57107778
149MP0004145_abnormal_muscle_electrophysio0.57001384
150MP0001958_emphysema0.56439250
151MP0002735_abnormal_chemical_nociception0.55095934
152MP0003690_abnormal_glial_cell0.55018533
153MP0005452_abnormal_adipose_tissue0.53737573
154MP0003953_abnormal_hormone_level0.53447259
155MP0005636_abnormal_mineral_homeostasis0.53367166
156MP0001486_abnormal_startle_reflex0.53224788
157MP0009672_abnormal_birth_weight0.52335897
158MP0002127_abnormal_cardiovascular_syste0.52198846
159MP0003119_abnormal_digestive_system0.52151348
160MP0005501_abnormal_skin_physiology0.51660933
161MP0001286_abnormal_eye_development0.51431229
162MP0008874_decreased_physiological_sensi0.49799662
163MP0002069_abnormal_eating/drinking_beha0.49036760
164MP0002148_abnormal_hypersensitivity_rea0.48581572
165MP0001873_stomach_inflammation0.44273441
166MP0000427_abnormal_hair_cycle0.44243645
167MP0010030_abnormal_orbit_morphology0.42965968
168MP0001243_abnormal_dermal_layer0.42693911
169MP0002234_abnormal_pharynx_morphology0.42486198
170MP0000647_abnormal_sebaceous_gland0.41895197
171MP0005166_decreased_susceptibility_to0.40212363
172MP0004036_abnormal_muscle_relaxation0.37874353
173MP0003941_abnormal_skin_development0.37262450
174MP0005623_abnormal_meninges_morphology0.35232179
175MP0000026_abnormal_inner_ear0.34724707
176MP0001177_atelectasis0.33358519
177MP0000428_abnormal_craniofacial_morphol0.31281441
178MP0000566_synostosis0.30160981
179MP0000631_abnormal_neuroendocrine_gland0.29838438
180MP0002877_abnormal_melanocyte_morpholog0.29759779
181MP0005076_abnormal_cell_differentiation0.29550666
182MP0000230_abnormal_systemic_arterial0.28972316
183MP0005666_abnormal_adipose_tissue0.27209114
184MP0003011_delayed_dark_adaptation0.25736821
185MP0005646_abnormal_pituitary_gland0.25146674
186MP0003448_altered_tumor_morphology0.23718901
187MP0008775_abnormal_heart_ventricle0.23138083

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.79785804
2Irregular epiphyses (HP:0010582)9.26667336
3Vitreoretinal degeneration (HP:0000655)7.41375767
4Small epiphyses (HP:0010585)6.84518776
5Abnormal tarsal ossification (HP:0008369)6.53703283
6Abnormality of the aortic arch (HP:0012303)6.44179929
7Cupped ribs (HP:0000887)6.40013232
8Broad alveolar ridges (HP:0000187)6.30797868
9Hypoplastic ischia (HP:0003175)6.26083404
10Volvulus (HP:0002580)6.19803555
11Pancreatic islet-cell hyperplasia (HP:0004510)6.13634616
12Intestinal atresia (HP:0011100)5.88926420
13Abnormality of the ischium (HP:0003174)5.53897615
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.53546457
15Delayed epiphyseal ossification (HP:0002663)5.49202387
16Thickened helices (HP:0000391)5.45795000
17Genu varum (HP:0002970)5.41593403
18Flat acetabular roof (HP:0003180)5.38788161
19Flat capital femoral epiphysis (HP:0003370)5.34442788
20Metaphyseal cupping (HP:0003021)5.23489369
21Abnormal foot bone ossification (HP:0010675)4.81887913
22Abnormality of the vertebral endplates (HP:0005106)4.76786154
23Metaphyseal dysplasia (HP:0100255)4.75068142
24Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.72306691
25Abnormality of femoral epiphyses (HP:0006499)4.72306691
26Poor head control (HP:0002421)4.70003105
27Oligodontia (HP:0000677)4.61221435
28Large for gestational age (HP:0001520)4.60860933
29Congenital ichthyosiform erythroderma (HP:0007431)4.58106678
30Large eyes (HP:0001090)4.45424371
31Mesangial abnormality (HP:0001966)4.43237183
32Flattened epiphyses (HP:0003071)4.41141450
33Abnormality of the epiphysis of the femoral head (HP:0010574)4.33732222
34Absent epiphyses (HP:0010577)4.29219017
35Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.29219017
36Short femoral neck (HP:0100864)4.25461763
37Hyperthyroidism (HP:0000836)4.25302794
38Neonatal short-limb short stature (HP:0008921)4.21986451
39Mild short stature (HP:0003502)4.16897567
40Irregular vertebral endplates (HP:0003301)4.14305367
41Arthropathy (HP:0003040)4.12179944
42Abnormality of the femoral head (HP:0003368)4.00078640
43Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99803586
44Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.91199344
45Osteoarthritis (HP:0002758)3.87696627
46Metaphyseal irregularity (HP:0003025)3.85540488
47Abnormality of endocrine pancreas physiology (HP:0012093)3.84861744
48Abnormality of the pancreatic islet cells (HP:0006476)3.84861744
49Gaze-evoked nystagmus (HP:0000640)3.71649491
50Abnormality of the ileum (HP:0001549)3.71072185
51Focal motor seizures (HP:0011153)3.56416828
52Chromsome breakage (HP:0040012)3.56398238
53Coxa vara (HP:0002812)3.55021298
54Agitation (HP:0000713)3.53433807
55Abnormality of carpal bone ossification (HP:0006257)3.44988987
56Hyperlipoproteinemia (HP:0010980)3.41171666
57Hypobetalipoproteinemia (HP:0003563)3.37298464
58Enlarged epiphyses (HP:0010580)3.28445341
59Abnormal vertebral ossification (HP:0100569)3.20103153
60Abnormality of the pubic bones (HP:0003172)3.18541196
61Beaking of vertebral bodies (HP:0004568)3.17958381
62Ectropion (HP:0000656)3.16918411
63Protuberant abdomen (HP:0001538)3.16206963
64Platyspondyly (HP:0000926)3.14222210
65Cerebellar dysplasia (HP:0007033)3.11480538
66Waddling gait (HP:0002515)3.10601599
67Ovoid vertebral bodies (HP:0003300)3.06001712
68Carpal bone hypoplasia (HP:0001498)3.04827855
69Abnormality of the phalanges of the 2nd finger (HP:0009541)3.03745048
70Abnormality of the proximal phalanges of the hand (HP:0009834)3.02462831
71Aplasia/hypoplasia of the femur (HP:0005613)3.00988410
72Limited elbow extension (HP:0001377)3.00675514
73Abnormality of the alveolar ridges (HP:0006477)2.98952271
74Type II lissencephaly (HP:0007260)2.98121235
75Tented upper lip vermilion (HP:0010804)2.95267028
76Gastrointestinal atresia (HP:0002589)2.92277645
77Thoracolumbar scoliosis (HP:0002944)2.88131123
78Barrel-shaped chest (HP:0001552)2.85560442
79Hypoproteinemia (HP:0003075)2.82633223
80Limited hip movement (HP:0008800)2.81052023
81Tubular atrophy (HP:0000092)2.76030207
82Severe visual impairment (HP:0001141)2.75611735
83Pigmentary retinal degeneration (HP:0001146)2.75359201
84Abnormal hand bone ossification (HP:0010660)2.74546569
85Vertebral clefting (HP:0008428)2.73287826
86Stillbirth (HP:0003826)2.70824405
87Cervical subluxation (HP:0003308)2.70501683
88Nonprogressive disorder (HP:0003680)2.68023603
89Spinal cord compression (HP:0002176)2.66185026
90Abnormal ossification of hand bones (HP:0005921)2.65061041
91High anterior hairline (HP:0009890)2.62745739
92Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.58571240
93Lumbar hyperlordosis (HP:0002938)2.56339283
94Absent frontal sinuses (HP:0002688)2.54256628
95Myositis (HP:0100614)2.54030946
96Optic nerve hypoplasia (HP:0000609)2.53883733
97Hypoplasia of the odontoid process (HP:0003311)2.52786312
98Nephroblastoma (Wilms tumor) (HP:0002667)2.50601274
99Hip contracture (HP:0003273)2.48849131
100Hypomagnesemia (HP:0002917)2.48746004
101Thin ribs (HP:0000883)2.47230639
102Abnormality of incisor morphology (HP:0011063)2.44609997
103Hyperpituitarism (HP:0010514)2.41848489
104Abnormality of the lumbar spine (HP:0100712)2.39146592
105Abnormality of pyrimidine metabolism (HP:0004353)2.38723880
106Entropion (HP:0000621)2.37772611
107Tetany (HP:0001281)2.35274133
108Exostoses (HP:0100777)2.35095363
109Ileus (HP:0002595)2.33374472
110Aplasia/Hypoplasia of the brainstem (HP:0007362)2.32771502
111Hypoplasia of the brainstem (HP:0002365)2.32771502
112Embryonal renal neoplasm (HP:0011794)2.32754510
113Glossoptosis (HP:0000162)2.32108509
114Abnormal hair laboratory examination (HP:0003328)2.31202110
115Abnormality of the vitreous humor (HP:0004327)2.26253386
116Abnormality of the 2nd finger (HP:0004100)2.25129530
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24666315
118Abnormality of nail color (HP:0100643)2.21551188
119Long clavicles (HP:0000890)2.19151904
120Poikiloderma (HP:0001029)2.19132016
121Impulsivity (HP:0100710)2.17606934
122Micromelia (HP:0002983)2.17328892
123Orchitis (HP:0100796)2.16900392
124Disproportionate short-trunk short stature (HP:0003521)2.16896062
125Broad-based gait (HP:0002136)2.15489033
126Poor speech (HP:0002465)2.14641557
127Pendular nystagmus (HP:0012043)2.14339649
128Aplasia/Hypoplasia of the spleen (HP:0010451)2.12463891
129Hypoplastic ilia (HP:0000946)2.11814784
130Hypoplastic pelvis (HP:0008839)2.11315012
131Fibular hypoplasia (HP:0003038)2.11103935
132Abnormality of the acetabulum (HP:0003170)2.10645977
133Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.09231599
134Short middle phalanx of finger (HP:0005819)2.08742627
135Abnormality of the odontoid process (HP:0003310)2.08630903
136Vertebral hypoplasia (HP:0008417)2.08563550
137Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.08563550
138Lissencephaly (HP:0001339)2.08092876
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.07941609
140Relative macrocephaly (HP:0004482)2.07572205
141Long nose (HP:0003189)2.07251555
142Mesomelia (HP:0003027)2.05999927
143Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04911465
144Abnormality of macular pigmentation (HP:0008002)2.03465343
145Hypoplasia of the pons (HP:0012110)2.03093781
146Goiter (HP:0000853)2.01550950
147Increased corneal curvature (HP:0100692)2.01394269
148Keratoconus (HP:0000563)2.01394269
149Thyroid-stimulating hormone excess (HP:0002925)13.2386323
150Restlessness (HP:0000711)1.96821426
151Focal seizures (HP:0007359)1.96486198
152Broad phalanx (HP:0006009)1.96148550
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95988095
154Asplenia (HP:0001746)1.95429618
155Abnormality of the common coagulation pathway (HP:0010990)1.94686652
156Flared metaphyses (HP:0003015)1.93705573
157Abnormality of magnesium homeostasis (HP:0004921)1.92277327
158Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.92021317
159Decreased circulating renin level (HP:0003351)1.91137570
160Abnormality of the phalanges of the 5th finger (HP:0004213)1.90949699
161Abnormal pancreas size (HP:0012094)1.84920859
162Radial bowing (HP:0002986)1.84355564
163Broad long bones (HP:0005622)1.84285482
164Late onset (HP:0003584)1.83390870
165Neonatal respiratory distress (HP:0002643)1.83354278
166Amelogenesis imperfecta (HP:0000705)1.82166329
167Short ribs (HP:0000773)1.81648993
168Abnormality of the middle phalanges of the toes (HP:0010183)1.81580040
169Pili torti (HP:0003777)1.81460703
170Joint stiffness (HP:0001387)1.81268989
171Abnormality of the pons (HP:0007361)1.80306428
172Mixed hearing impairment (HP:0000410)1.79760810
173Elevated erythrocyte sedimentation rate (HP:0003565)1.79400181
174Cutaneous melanoma (HP:0012056)1.78458926
175Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.77562815
176Central scotoma (HP:0000603)1.76620023
177Abnormality of the frontal sinuses (HP:0002687)1.76486516
178Ulnar bowing (HP:0003031)1.76412937
179Duplicated collecting system (HP:0000081)1.76301497
180Ulnar deviation of the wrist (HP:0003049)1.74005238
181Hypolipoproteinemia (HP:0010981)1.72857801
182Malnutrition (HP:0004395)1.72833699
183Genu valgum (HP:0002857)1.71867172
184Truncal obesity (HP:0001956)1.71484774
185Dialeptic seizures (HP:0011146)1.69879520
186Attenuation of retinal blood vessels (HP:0007843)1.69126424
187Striae distensae (HP:0001065)1.68190018
188Generalized tonic-clonic seizures (HP:0002069)1.67676281
189Scotoma (HP:0000575)1.67421789
190Abnormality of the renal collecting system (HP:0004742)1.66314847
191Hypercortisolism (HP:0001578)1.66012920
192Hypoplasia of the iris (HP:0007676)1.65721355
193Severe Myopia (HP:0011003)1.63431549
1943-Methylglutaconic aciduria (HP:0003535)1.62477889
195Hyperglycinemia (HP:0002154)1.62301538
196Dysdiadochokinesis (HP:0002075)1.62209130
197Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.61966275
198Abnormality of glycine metabolism (HP:0010895)1.59714863
199Abnormality of serine family amino acid metabolism (HP:0010894)1.59714863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.13967202
2MAP3K37.06308779
3STK38L5.77307444
4STK245.64349905
5ERN15.14902648
6NME15.08742733
7FRK4.58380053
8PIK3CG4.20858250
9PRKG23.96693295
10PINK13.70350549
11IRAK33.39092159
12MST42.33761471
13TYRO32.05956896
14ADRBK210.4669902
15ERBB31.93338122
16ACVR1B1.90232601
17PLK21.81571644
18PNCK1.77439789
19STK31.77019642
20IRAK11.74154107
21LATS11.69242796
22CLK11.67210241
23TAOK11.65413058
24PRKCE1.45551137
25DYRK31.43306205
26PIM21.42587860
27MAPK111.41286571
28NUAK11.40936851
29EIF2AK31.40199015
30DYRK1A1.38790597
31BCKDK1.38567547
32TESK21.35099779
33MKNK21.33894755
34PLK41.30686811
35NME21.30434146
36MAPK121.14310077
37EIF2AK11.13945197
38CAMKK21.08998867
39SIK11.06757199
40GRK11.06721339
41MAPK71.01188432
42PIK3CA1.00475832
43TRPM70.98839973
44BCR0.93028339
45PBK0.91410124
46ROCK10.88606208
47MAPK40.86701805
48RIPK10.81194823
49MKNK10.79978511
50NEK60.79477521
51PDK20.77155556
52NEK90.76630278
53WNK40.74982266
54FGFR20.74440460
55EPHA20.71917163
56GSK3A0.71644961
57CAMK1G0.69467040
58MUSK0.69411188
59BRSK10.64789550
60MET0.61998724
61FGFR30.61507682
62NEK20.60514216
63RPS6KA40.57422224
64MAP2K30.57242853
65WNK30.57191039
66CAMK2A0.56204053
67ERBB20.52587734
68LIMK10.51851395
69EPHB10.51286620
70MARK30.50299781
71TRIB30.50128190
72MAP4K20.49749451
73CAMK10.49275331
74KSR10.48702278
75STK390.48030359
76PLK30.44001806
77PRKG10.43200491
78PIM10.42054711
79CSF1R0.40833059
80PTK2B0.39270320
81TAOK20.38596339
82CSNK2A20.36943751
83GRK70.36349282
84TESK10.35860434
85TGFBR10.35804662
86WEE10.35377199
87MAP2K20.35369592
88MELK0.35086572
89NLK0.34992342
90CAMKK10.34435430
91PRKCB0.33519069
92PRKACG0.31479065
93CSNK1A1L0.30351276
94AKT10.30088420
95MAPKAPK50.29848664
96EIF2AK20.29342076
97LATS20.27825557
98BRSK20.27036388
99MAP2K10.26726353
100NTRK20.26652759
101STK380.26489837
102EPHA30.26437564
103MAP3K50.26431729
104MAP3K110.25847986
105CSNK1E0.25840404
106EPHA40.25298092
107RPS6KA30.25096023
108ATR0.24762659
109BMPR20.24556990
110FLT30.23414266
111PRKCD0.22673463
112PRKCH0.21716780
113EPHB20.21337460
114RPS6KB10.20937457
115SGK10.20911406
116MAP3K20.20355898
117CSNK2A10.20020091
118IGF1R0.19709644
119MAPK30.19661867
120MAPK100.19250223
121FGFR10.18821028
122GSK3B0.18767741
123PRKACB0.18738134
124AURKB0.18280759
125CDK70.17875246
126CAMK40.17698219
127RIPK40.16848904
128FER0.16830226
129KDR0.16200320
130CSNK1A10.16085530
131ABL10.15289026
132TAOK30.14549578
133MAP3K120.14064928
134MAPK10.14062704
135BMPR1B0.13735435
136MAP3K80.12724376
137PRKACA0.12671131
138TXK0.12515091
139PTK20.12465825
140ERBB40.12208540
141CHEK20.12101801
142ADRBK10.11899737
143PDK10.11648862
144GRK50.11275940
145CDK10.11012680
146PRKAA10.10784652
147BRD40.10680673
148CSNK1G10.10126244
149CSK0.10017561
150PKN20.09910738
151PRKD30.09874269
152ROCK20.09450909
153TEC0.09436189
154CHUK0.09340110
155CDK40.09313751
156CDK20.09080148
157PRKCI0.09033925
158PKN10.08919197
159PRKCA0.08729844
160PRKCQ0.08679484
161RPS6KA50.08627343
162NTRK30.08259296
163TGFBR20.08019744
164CDK90.07998752
165INSR0.07948670
166IKBKB0.07703125
167MAPK140.07672094
168IRAK40.07407589
169PDGFRB0.07302640
170MST1R0.07156712
171CDK50.06911565
172PRKCG0.06756921
173OXSR10.06329454
174PAK30.06004456

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005327.92066333
2ECM-receptor interaction_Homo sapiens_hsa045126.25867915
3Protein digestion and absorption_Homo sapiens_hsa049745.72131709
4Dorso-ventral axis formation_Homo sapiens_hsa043203.74241455
5Sphingolipid metabolism_Homo sapiens_hsa006003.32066244
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.00357542
7Sulfur metabolism_Homo sapiens_hsa009202.90533781
8Steroid biosynthesis_Homo sapiens_hsa001002.85206714
9ABC transporters_Homo sapiens_hsa020102.59477949
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.50090121
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.46611419
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.42747627
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.35116833
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33532844
15Pentose phosphate pathway_Homo sapiens_hsa000302.31974107
16Linoleic acid metabolism_Homo sapiens_hsa005912.29974135
17Focal adhesion_Homo sapiens_hsa045102.27827504
18Protein export_Homo sapiens_hsa030602.08995829
19Fanconi anemia pathway_Homo sapiens_hsa034602.08805017
20Glycerolipid metabolism_Homo sapiens_hsa005612.08256761
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04169196
22Olfactory transduction_Homo sapiens_hsa047401.93954302
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88220795
24Malaria_Homo sapiens_hsa051441.85986087
25Phototransduction_Homo sapiens_hsa047441.81016623
26Morphine addiction_Homo sapiens_hsa050321.80070564
27Butanoate metabolism_Homo sapiens_hsa006501.78759422
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.69676949
29TGF-beta signaling pathway_Homo sapiens_hsa043501.69321874
30Starch and sucrose metabolism_Homo sapiens_hsa005001.69074906
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62002053
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61247152
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57129983
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.55594959
35Fat digestion and absorption_Homo sapiens_hsa049751.55020547
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46465610
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41872033
38Selenocompound metabolism_Homo sapiens_hsa004501.41001820
39Tryptophan metabolism_Homo sapiens_hsa003801.32136457
40Ether lipid metabolism_Homo sapiens_hsa005651.26513981
41Basal transcription factors_Homo sapiens_hsa030221.22668679
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17786949
43Sulfur relay system_Homo sapiens_hsa041221.17070821
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16522073
45Chemical carcinogenesis_Homo sapiens_hsa052041.15933749
46Other glycan degradation_Homo sapiens_hsa005111.15810300
47Arginine and proline metabolism_Homo sapiens_hsa003301.14581600
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12520020
49Hedgehog signaling pathway_Homo sapiens_hsa043401.08781700
50Folate biosynthesis_Homo sapiens_hsa007901.05845224
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.04227913
52Arginine biosynthesis_Homo sapiens_hsa002201.01529392
53Taste transduction_Homo sapiens_hsa047421.01388549
54Fatty acid degradation_Homo sapiens_hsa000710.99692382
55Ovarian steroidogenesis_Homo sapiens_hsa049130.98610001
56Hippo signaling pathway_Homo sapiens_hsa043900.96478770
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94810457
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88893064
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87592456
60One carbon pool by folate_Homo sapiens_hsa006700.87453589
61Phagosome_Homo sapiens_hsa041450.86330714
62Homologous recombination_Homo sapiens_hsa034400.85268427
63Vibrio cholerae infection_Homo sapiens_hsa051100.85211848
64Galactose metabolism_Homo sapiens_hsa000520.84451310
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84043272
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82433018
67Glutathione metabolism_Homo sapiens_hsa004800.80380828
68Proteoglycans in cancer_Homo sapiens_hsa052050.79409364
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78159515
70Basal cell carcinoma_Homo sapiens_hsa052170.77072547
71N-Glycan biosynthesis_Homo sapiens_hsa005100.76509756
72Long-term depression_Homo sapiens_hsa047300.74919551
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74512813
74Nitrogen metabolism_Homo sapiens_hsa009100.72269491
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.70475414
76Nicotine addiction_Homo sapiens_hsa050330.65426653
77PPAR signaling pathway_Homo sapiens_hsa033200.65303500
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63753401
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60972927
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60550264
81Estrogen signaling pathway_Homo sapiens_hsa049150.59927770
82Salivary secretion_Homo sapiens_hsa049700.57758421
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.57406918
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.55298162
85Non-homologous end-joining_Homo sapiens_hsa034500.54960783
86Calcium signaling pathway_Homo sapiens_hsa040200.53601993
87mRNA surveillance pathway_Homo sapiens_hsa030150.53490944
88Thyroid hormone synthesis_Homo sapiens_hsa049180.51417380
89Cardiac muscle contraction_Homo sapiens_hsa042600.51327897
90Arachidonic acid metabolism_Homo sapiens_hsa005900.50909566
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49886914
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48441123
93Circadian entrainment_Homo sapiens_hsa047130.44725723
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44688198
95Gap junction_Homo sapiens_hsa045400.44608550
96Purine metabolism_Homo sapiens_hsa002300.44485379
97GnRH signaling pathway_Homo sapiens_hsa049120.42152235
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41524484
99HIF-1 signaling pathway_Homo sapiens_hsa040660.39826907
100Caffeine metabolism_Homo sapiens_hsa002320.39576702
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38850899
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37896622
103Dilated cardiomyopathy_Homo sapiens_hsa054140.37752556
104Wnt signaling pathway_Homo sapiens_hsa043100.36484497
105Lysine degradation_Homo sapiens_hsa003100.36442876
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36155928
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36089493
108Cocaine addiction_Homo sapiens_hsa050300.35861669
109Vitamin digestion and absorption_Homo sapiens_hsa049770.35759406
110Pancreatic secretion_Homo sapiens_hsa049720.35446215
111Melanogenesis_Homo sapiens_hsa049160.34636385
112Propanoate metabolism_Homo sapiens_hsa006400.34492384
113MicroRNAs in cancer_Homo sapiens_hsa052060.33672707
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32555416
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31456161
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30399224
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.28972828
118Oxytocin signaling pathway_Homo sapiens_hsa049210.28153937
119Glutamatergic synapse_Homo sapiens_hsa047240.26840206
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26035596
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25800912
122Legionellosis_Homo sapiens_hsa051340.25277216
123Biosynthesis of amino acids_Homo sapiens_hsa012300.23040998
124Peroxisome_Homo sapiens_hsa041460.20867045
125Pyruvate metabolism_Homo sapiens_hsa006200.20830228
126Histidine metabolism_Homo sapiens_hsa003400.20302477
127Amphetamine addiction_Homo sapiens_hsa050310.20021338
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.19896290
129RNA degradation_Homo sapiens_hsa030180.19879518
130Platelet activation_Homo sapiens_hsa046110.19098642
131Complement and coagulation cascades_Homo sapiens_hsa046100.18666184
132Lysosome_Homo sapiens_hsa041420.18497346
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18275202
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17967169
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16859617
136Fatty acid biosynthesis_Homo sapiens_hsa000610.16618130
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15950222
138Base excision repair_Homo sapiens_hsa034100.15564992
139Hematopoietic cell lineage_Homo sapiens_hsa046400.15449526
140Metabolic pathways_Homo sapiens_hsa011000.15440103
141Bladder cancer_Homo sapiens_hsa052190.15218371
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15000820
143Retinol metabolism_Homo sapiens_hsa008300.14873681
144cAMP signaling pathway_Homo sapiens_hsa040240.14513803
145Cholinergic synapse_Homo sapiens_hsa047250.14216494
146Adherens junction_Homo sapiens_hsa045200.13242855
147Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.12932107
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12604942
149Bile secretion_Homo sapiens_hsa049760.11725393
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11566197
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11314008
152Hepatitis B_Homo sapiens_hsa051610.09794397
153Renin secretion_Homo sapiens_hsa049240.09480639
154Insulin secretion_Homo sapiens_hsa049110.08682965
155Prostate cancer_Homo sapiens_hsa052150.07973461
156Amoebiasis_Homo sapiens_hsa051460.07941542
157Insulin resistance_Homo sapiens_hsa049310.07278771
158Renal cell carcinoma_Homo sapiens_hsa052110.06954182
159HTLV-I infection_Homo sapiens_hsa051660.05421033
160Mineral absorption_Homo sapiens_hsa049780.05025995
161Glucagon signaling pathway_Homo sapiens_hsa049220.05012859
162Axon guidance_Homo sapiens_hsa043600.04950464
163Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04674139
164Steroid hormone biosynthesis_Homo sapiens_hsa001400.04402865
165Osteoclast differentiation_Homo sapiens_hsa043800.04274668

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