PAOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.63751536
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.63751536
3aromatic amino acid family catabolic process (GO:0009074)6.41865120
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.37336287
5L-phenylalanine metabolic process (GO:0006558)6.37336287
6indole-containing compound catabolic process (GO:0042436)6.25864168
7indolalkylamine catabolic process (GO:0046218)6.25864168
8tryptophan catabolic process (GO:0006569)6.25864168
9tryptophan metabolic process (GO:0006568)5.97654615
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.66562264
11kynurenine metabolic process (GO:0070189)5.62913010
12urea cycle (GO:0000050)5.24602069
13urea metabolic process (GO:0019627)5.24602069
14bile acid biosynthetic process (GO:0006699)5.18138627
15high-density lipoprotein particle remodeling (GO:0034375)5.03971731
16peptidyl-glutamic acid carboxylation (GO:0017187)4.88084931
17protein carboxylation (GO:0018214)4.88084931
18nitrogen cycle metabolic process (GO:0071941)4.77740606
19glyoxylate metabolic process (GO:0046487)4.77509564
20complement activation, alternative pathway (GO:0006957)4.77036281
21sulfur amino acid catabolic process (GO:0000098)4.71508225
22aromatic amino acid family metabolic process (GO:0009072)4.70946116
23serine family amino acid catabolic process (GO:0009071)4.67578914
24regulation of protein activation cascade (GO:2000257)4.60094556
25imidazole-containing compound metabolic process (GO:0052803)4.59678224
26regulation of fibrinolysis (GO:0051917)4.59468807
27bile acid metabolic process (GO:0008206)4.57649501
28* amine catabolic process (GO:0009310)4.52939785
29* cellular biogenic amine catabolic process (GO:0042402)4.52939785
30regulation of cholesterol esterification (GO:0010872)4.52131542
31homocysteine metabolic process (GO:0050667)4.51090999
32phospholipid efflux (GO:0033700)4.50739793
33negative regulation of fibrinolysis (GO:0051918)4.50472409
34indolalkylamine metabolic process (GO:0006586)4.50072051
35alpha-linolenic acid metabolic process (GO:0036109)4.47147399
36cysteine metabolic process (GO:0006534)4.43970888
37tyrosine metabolic process (GO:0006570)4.36039893
38protein-lipid complex remodeling (GO:0034368)4.35225176
39macromolecular complex remodeling (GO:0034367)4.35225176
40plasma lipoprotein particle remodeling (GO:0034369)4.35225176
41glycine metabolic process (GO:0006544)4.31524316
42regulation of triglyceride catabolic process (GO:0010896)4.30508976
43regulation of complement activation (GO:0030449)4.28355937
44reverse cholesterol transport (GO:0043691)4.28016930
45amino-acid betaine metabolic process (GO:0006577)4.26443894
46regulation of interferon-beta biosynthetic process (GO:0045357)4.24383948
47acylglycerol homeostasis (GO:0055090)4.24006836
48triglyceride homeostasis (GO:0070328)4.24006836
49alpha-amino acid catabolic process (GO:1901606)4.20739033
50bile acid and bile salt transport (GO:0015721)4.20163608
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.19777319
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.17451978
53NAD biosynthetic process (GO:0009435)4.15623265
54negative regulation of sterol transport (GO:0032372)4.01022636
55negative regulation of cholesterol transport (GO:0032375)4.01022636
56NIK/NF-kappaB signaling (GO:0038061)3.96523344
57cellular glucuronidation (GO:0052695)3.94208806
58low-density lipoprotein particle remodeling (GO:0034374)3.94163726
59coenzyme catabolic process (GO:0009109)3.93565290
60regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.91812704
61nicotinamide nucleotide biosynthetic process (GO:0019359)3.88098734
62pyridine nucleotide biosynthetic process (GO:0019363)3.88098734
63negative regulation of lipase activity (GO:0060192)3.87536278
64positive regulation by organism of defense response of other organism involved in symbiotic interact3.87450224
65modulation by symbiont of host immune response (GO:0052553)3.87450224
66positive regulation by symbiont of host defense response (GO:0052509)3.87450224
67modulation by symbiont of host defense response (GO:0052031)3.87450224
68modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.87450224
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.87450224
70blood coagulation, intrinsic pathway (GO:0007597)3.85182404
71antigen processing and presentation of endogenous antigen (GO:0019883)3.83479785
72benzene-containing compound metabolic process (GO:0042537)3.80945956
73cholesterol efflux (GO:0033344)3.80940912
74plasma lipoprotein particle clearance (GO:0034381)3.80316083
75serine family amino acid metabolic process (GO:0009069)3.78325853
76serine family amino acid biosynthetic process (GO:0009070)3.77938637
77cellular amino acid catabolic process (GO:0009063)3.77739973
78macrophage activation involved in immune response (GO:0002281)3.75922525
79plasma lipoprotein particle assembly (GO:0034377)3.74412000
80aldehyde catabolic process (GO:0046185)3.73480373
81very-low-density lipoprotein particle assembly (GO:0034379)3.68278030
82ethanol oxidation (GO:0006069)3.66681369
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.61772626
84fibrinolysis (GO:0042730)3.59492775
85lysine metabolic process (GO:0006553)3.54458925
86lysine catabolic process (GO:0006554)3.54458925
87glucuronate metabolic process (GO:0019585)3.52302813
88uronic acid metabolic process (GO:0006063)3.52302813
89protein activation cascade (GO:0072376)3.50795888
90arginine metabolic process (GO:0006525)3.47282952
91drug catabolic process (GO:0042737)3.47182425
92cofactor catabolic process (GO:0051187)3.42783907
93response to nitrosative stress (GO:0051409)3.42735554
94low-density lipoprotein particle clearance (GO:0034383)3.42510525
95positive regulation of lipoprotein lipase activity (GO:0051006)3.40104302
96positive regulation of triglyceride lipase activity (GO:0061365)3.40104302
97regulation of bile acid biosynthetic process (GO:0070857)3.39462990
98plasma lipoprotein particle organization (GO:0071827)3.39060544
99complement activation (GO:0006956)3.37636118
100carboxylic acid catabolic process (GO:0046395)3.35469661
101organic acid catabolic process (GO:0016054)3.35469661
102opsonization (GO:0008228)3.34845161
103cholesterol homeostasis (GO:0042632)3.33807497
104complement activation, classical pathway (GO:0006958)3.33744732
105cellular modified amino acid catabolic process (GO:0042219)3.33688067
106phospholipid homeostasis (GO:0055091)3.33648199
107B cell receptor signaling pathway (GO:0050853)3.31373651
108cellular ketone body metabolic process (GO:0046950)3.29815663
109detection of other organism (GO:0098543)3.27652201
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27051005
111sterol homeostasis (GO:0055092)3.25655971
112detection of bacterium (GO:0016045)3.21216093
113regulation of dendritic cell antigen processing and presentation (GO:0002604)3.20766077
114fusion of sperm to egg plasma membrane (GO:0007342)3.20361862
115linoleic acid metabolic process (GO:0043651)3.18847479
116positive regulation of Cdc42 GTPase activity (GO:0043089)3.18188079
117carnitine metabolic process (GO:0009437)3.17230293
118protein-lipid complex assembly (GO:0065005)3.15339808
119lipoprotein metabolic process (GO:0042157)3.14699222
120intestinal cholesterol absorption (GO:0030299)3.14115035
121glutamate metabolic process (GO:0006536)3.12666756
122neutrophil activation involved in immune response (GO:0002283)3.06432167
123immunoglobulin mediated immune response (GO:0016064)3.02499335
124positive regulation of gamma-delta T cell activation (GO:0046645)3.00503532
125negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96702676
126negative regulation of cell killing (GO:0031342)2.96702676
127glycosphingolipid catabolic process (GO:0046479)2.95753567
128lipoxygenase pathway (GO:0019372)2.95528609
129hyaluronan catabolic process (GO:0030214)2.94536424
130peptide catabolic process (GO:0043171)2.89433412
131negative regulation of erythrocyte differentiation (GO:0045647)2.82694130
132mannose metabolic process (GO:0006013)2.82334985
133positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.82244702
134type I interferon signaling pathway (GO:0060337)2.73357778
135cellular response to type I interferon (GO:0071357)2.73357778
136regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73219659
137response to type I interferon (GO:0034340)2.72336367
138regulation of antigen processing and presentation (GO:0002577)2.71167025
139regulation of early endosome to late endosome transport (GO:2000641)2.69844114
140regulation of B cell receptor signaling pathway (GO:0050855)2.69012353
141* polyamine biosynthetic process (GO:0006596)2.67902258
142positive regulation of histone deacetylation (GO:0031065)2.64587748
143adenosine receptor signaling pathway (GO:0001973)2.64283650
144sperm motility (GO:0030317)2.62853590
145detection of external biotic stimulus (GO:0098581)2.62358901
146positive regulation of type 2 immune response (GO:0002830)2.62287196
147amino sugar catabolic process (GO:0046348)2.59614353
148glycolipid catabolic process (GO:0019377)2.59606917
149positive regulation of antigen processing and presentation (GO:0002579)2.59567750
150epoxygenase P450 pathway (GO:0019373)2.57931197
151membrane protein intracellular domain proteolysis (GO:0031293)2.57910289
152diacylglycerol metabolic process (GO:0046339)2.57093836
153regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.56373321
154sperm capacitation (GO:0048240)2.52729189
155interferon-gamma-mediated signaling pathway (GO:0060333)2.51158189
156myeloid dendritic cell differentiation (GO:0043011)2.49087354
157regulation of mast cell degranulation (GO:0043304)2.47751755
158myeloid cell activation involved in immune response (GO:0002275)2.44959322
159regulation of T-helper 2 cell differentiation (GO:0045628)2.44446565
160N-acetylneuraminate metabolic process (GO:0006054)2.44083746
161response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.43318154
162response to host immune response (GO:0052572)2.43318154
163cellular response to pH (GO:0071467)2.41284690
164positive regulation of T cell mediated cytotoxicity (GO:0001916)2.41260989
165positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.39357921
166response to acidic pH (GO:0010447)2.39198237
167sexual reproduction (GO:0019953)2.38707768
168tyrosine phosphorylation of STAT protein (GO:0007260)2.38042897
169adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.37548342
170regulation of gamma-delta T cell activation (GO:0046643)2.37438658
171regulation of interferon-gamma biosynthetic process (GO:0045072)2.35520056
172detection of biotic stimulus (GO:0009595)2.34255832
173lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33498199
174regulation of female gonad development (GO:2000194)2.32948570
175B cell homeostasis (GO:0001782)2.29846154
176outer ear morphogenesis (GO:0042473)2.26550271
177acrosome reaction (GO:0007340)2.25733751
178leukocyte migration involved in inflammatory response (GO:0002523)2.25192424
179cellular response to interferon-beta (GO:0035458)2.24920364
180response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.24690772
181response to host (GO:0075136)2.24690772
182response to host defenses (GO:0052200)2.24690772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.97652537
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.38346819
3RXR_22158963_ChIP-Seq_LIVER_Mouse7.10146691
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.10617771
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.34736112
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.33479037
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.38758666
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.38355173
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.67217089
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.60180527
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.18343131
12LXR_22292898_ChIP-Seq_THP-1_Human3.00126748
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.42879433
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.41743718
15MYC_22102868_ChIP-Seq_BL_Human2.40045365
16VDR_21846776_ChIP-Seq_THP-1_Human2.36645112
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30805307
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.19099158
19* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15225016
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.11749853
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00375735
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98916132
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98141064
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95841852
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95618330
26* MAF_26560356_Chip-Seq_TH1_Human1.93483849
27BCL6_27268052_Chip-Seq_Bcells_Human1.91789401
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.88271896
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87394369
30E2F7_22180533_ChIP-Seq_HELA_Human1.86927527
31BCOR_27268052_Chip-Seq_Bcells_Human1.86471290
32P68_20966046_ChIP-Seq_HELA_Human1.86435256
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.83805597
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83149507
35GATA1_19941827_ChIP-Seq_MEL_Mouse1.78195892
36KDM2B_26808549_Chip-Seq_DND41_Human1.72792138
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71812362
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70443744
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.69551643
40* SA1_27219007_Chip-Seq_ERYTHROID_Human1.66659576
41TCF7_22412390_ChIP-Seq_EML_Mouse1.64526260
42MAF_26560356_Chip-Seq_TH2_Human1.64255798
43* RACK7_27058665_Chip-Seq_MCF-7_Human1.63589546
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63440528
45GATA1_22025678_ChIP-Seq_K562_Human1.63220105
46TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.61951233
47VDR_24763502_ChIP-Seq_THP-1_Human1.61144704
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.59120566
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56443511
50HTT_18923047_ChIP-ChIP_STHdh_Human1.56245464
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55171944
52SA1_27219007_Chip-Seq_Bcells_Human1.53557179
53SMC4_20622854_ChIP-Seq_HELA_Human1.53538847
54UTX_26944678_Chip-Seq_JUKART_Human1.52142307
55SPI1_23127762_ChIP-Seq_K562_Human1.50776838
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.49514207
57* CTCF_27219007_Chip-Seq_Bcells_Human1.45500417
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42710251
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42404861
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40768374
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.39499530
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38727466
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.38070034
64GATA1_19941826_ChIP-Seq_K562_Human1.37596166
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37219100
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36598996
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.35946842
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35932648
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35772494
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35435929
71PHF8_20622854_ChIP-Seq_HELA_Human1.33873589
72IRF1_19129219_ChIP-ChIP_H3396_Human1.32891023
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32124877
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30810959
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30441171
76TP63_22573176_ChIP-Seq_HFKS_Human1.30175326
77E2F1_20622854_ChIP-Seq_HELA_Human1.29546960
78* SPI1_20517297_ChIP-Seq_HL60_Human1.29399458
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.28914495
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28762416
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26445985
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26173243
83* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26026909
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25543559
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25199177
86CTCF_20526341_ChIP-Seq_ESCs_Human1.22528076
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21914945
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21229410
89CTCF_21964334_Chip-Seq_Bcells_Human1.20996222
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20689944
91P300_27268052_Chip-Seq_Bcells_Human1.20227156
92NCOR1_26117541_ChIP-Seq_K562_Human1.19593952
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.18684650
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16257684
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16060406
96KDM2B_26808549_Chip-Seq_K562_Human1.15789119
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15473410
98CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14905103
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14889042
100STAT1_20625510_ChIP-Seq_HELA_Human1.14870385
101CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13654798
102TP63_17297297_ChIP-ChIP_HaCaT_Human1.13355770
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13179251
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12247098
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10723428
106HNF4A_19822575_ChIP-Seq_HepG2_Human1.10024051
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.09564992
108SCL_19346495_ChIP-Seq_HPC-7_Human1.09030187
109RUNX_20019798_ChIP-Seq_JUKART_Human1.07463183
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06717001
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06702959
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.06171777
113KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05366010
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05090979
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02310232
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99666049
117IRF8_27001747_Chip-Seq_BMDM_Mouse0.97596923
118GATA4_25053715_ChIP-Seq_YYC3_Human0.95130593
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93205494
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.92957685
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90520520
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87649927
123AR_20517297_ChIP-Seq_VCAP_Human0.86912449
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.86302386
125STAT1_17558387_ChIP-Seq_HELA_Human0.86034236
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85453492
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.84821361
128* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84694185
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.84345048
130RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84027093
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83632294
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81224047
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.80700484
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80273468
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76739050
136NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76523085
137SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75539524
138FOXA2_19822575_ChIP-Seq_HepG2_Human0.75397511
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75216642
140OCT4_21477851_ChIP-Seq_ESCs_Mouse0.74489007
141LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71977783
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71897486
143ESRRB_18555785_Chip-Seq_ESCs_Mouse0.70746395
144CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70625651
145CDX2_20551321_ChIP-Seq_CACO-2_Human0.69736475
146BP1_19119308_ChIP-ChIP_Hs578T_Human0.68607884
147CEBPB_22108803_ChIP-Seq_LS180_Human0.68537272
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68255991
149BRD4_27068464_Chip-Seq_AML-cells_Mouse0.67979113
150SMAD1_18555785_Chip-Seq_ESCs_Mouse0.67425202
151RARA_24833708_ChIP-Seq_LIVER_Mouse0.67040973
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66538614
153PU1_27457419_Chip-Seq_LIVER_Mouse0.66187330
154EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.64720101
155OCT4_18555785_Chip-Seq_ESCs_Mouse0.64569684
156STAT3_18555785_Chip-Seq_ESCs_Mouse0.64100330
157ZFX_18555785_Chip-Seq_ESCs_Mouse0.61856023
158GATA2_22383799_ChIP-Seq_G1ME_Mouse0.61394054
159PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.61302259
160MYB_21317192_ChIP-Seq_ERMYB_Mouse0.60790650
161MYC_18940864_ChIP-ChIP_HL60_Human0.60373791
162* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.58864068
163NMYC_18555785_Chip-Seq_ESCs_Mouse0.57995368
164RARB_24833708_ChIP-Seq_LIVER_Mouse0.57662820
165SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57265939
166SUZ12_18555785_Chip-Seq_ESCs_Mouse0.56681004
167ESET_19884257_ChIP-Seq_ESCs_Mouse0.55845877
168AUTS2_25519132_ChIP-Seq_293T-REX_Human0.55638103
169P53_22387025_ChIP-Seq_ESCs_Mouse0.55423525
170JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.55391950
171FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55224267
172P300_18555785_Chip-Seq_ESCs_Mouse0.54930769
173CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.54921818
174GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.54321725
175EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.54182284
176STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54058941

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.45834813
2MP0005360_urolithiasis6.45331958
3MP0005085_abnormal_gallbladder_physiolo5.89506367
4MP0005365_abnormal_bile_salt5.65478997
5MP0008875_abnormal_xenobiotic_pharmacok4.45181406
6MP0003806_abnormal_nucleotide_metabolis3.30516038
7MP0003252_abnormal_bile_duct3.25033190
8MP0010329_abnormal_lipoprotein_level3.11418173
9MP0000685_abnormal_immune_system2.84079590
10MP0004510_myositis2.66067568
11MP0005410_abnormal_fertilization2.65698850
12MP0009840_abnormal_foam_cell2.59816225
13MP0003303_peritoneal_inflammation2.50251152
14MP0003195_calcinosis2.50236429
15MP0005083_abnormal_biliary_tract2.48674755
16MP0005058_abnormal_lysosome_morphology2.43594047
17MP0001666_abnormal_nutrient_absorption2.43348573
18MP0004019_abnormal_vitamin_homeostasis2.32545422
19MP0001790_abnormal_immune_system2.31812247
20MP0005387_immune_system_phenotype2.31812247
21MP0005671_abnormal_response_to2.22924012
22MP0009697_abnormal_copulation2.21621112
23MP0005451_abnormal_body_composition2.17185656
24MP0005332_abnormal_amino_acid2.11275930
25MP0005000_abnormal_immune_tolerance2.01228208
26MP0000678_abnormal_parathyroid_gland2.00756427
27MP0000609_abnormal_liver_physiology1.94134047
28MP0003191_abnormal_cellular_cholesterol1.93694933
29MP0002452_abnormal_antigen_presenting1.91234513
30MP0001764_abnormal_homeostasis1.90126460
31MP0005310_abnormal_salivary_gland1.84648340
32MP0002138_abnormal_hepatobiliary_system1.84415897
33MP0003868_abnormal_feces_composition1.80761435
34MP0001348_abnormal_lacrimal_gland1.79465854
35MP0004947_skin_inflammation1.72519419
36MP0002118_abnormal_lipid_homeostasis1.70754085
37MP0003186_abnormal_redox_activity1.70620714
38MP0001873_stomach_inflammation1.69338684
39MP0002420_abnormal_adaptive_immunity1.65196643
40MP0001819_abnormal_immune_cell1.64833168
41MP0009333_abnormal_splenocyte_physiolog1.59896474
42MP0002254_reproductive_system_inflammat1.56153369
43MP0005319_abnormal_enzyme/_coenzyme1.55065854
44MP0003705_abnormal_hypodermis_morpholog1.54497152
45MP0003172_abnormal_lysosome_physiology1.50697561
46MP0009764_decreased_sensitivity_to1.46540038
47MP0004381_abnormal_hair_follicle1.43234365
48MP0003300_gastrointestinal_ulcer1.40144211
49MP0000716_abnormal_immune_system1.34528963
50MP0002398_abnormal_bone_marrow1.33636010
51MP0003011_delayed_dark_adaptation1.33254520
52MP0000604_amyloidosis1.29395664
53MP0003879_abnormal_hair_cell1.28290825
54MP0005647_abnormal_sex_gland1.28029590
55MP0003724_increased_susceptibility_to1.24270998
56MP0003763_abnormal_thymus_physiology1.24018166
57MP0005670_abnormal_white_adipose1.20799062
58MP0002132_abnormal_respiratory_system1.17475141
59MP0005584_abnormal_enzyme/coenzyme_acti1.17299739
60MP0002405_respiratory_system_inflammati1.16082287
61MP0001533_abnormal_skeleton_physiology1.15960340
62MP0000689_abnormal_spleen_morphology1.15758598
63MP0009763_increased_sensitivity_to1.13356605
64MP0003183_abnormal_peptide_metabolism1.12638259
65MP0005075_abnormal_melanosome_morpholog1.12093696
66MP0002429_abnormal_blood_cell1.11317793
67MP0008469_abnormal_protein_level1.10991761
68MP0003436_decreased_susceptibility_to1.08580572
69MP0008260_abnormal_autophagy1.06882182
70MP0000598_abnormal_liver_morphology1.06341779
71MP0000465_gastrointestinal_hemorrhage1.05284169
72MP0005464_abnormal_platelet_physiology1.03684872
73MP0003329_amyloid_beta_deposits1.02396030
74MP0002722_abnormal_immune_system1.02318794
75MP0004782_abnormal_surfactant_physiolog1.02249683
76MP0000343_altered_response_to1.01589811
77MP0000249_abnormal_blood_vessel1.01490435
78MP0000566_synostosis1.00853961
79MP0000858_altered_metastatic_potential1.00234835
80MP0003656_abnormal_erythrocyte_physiolo1.00091319
81MP0009643_abnormal_urine_homeostasis0.99070202
82MP0005408_hypopigmentation0.96977525
83MP0001835_abnormal_antigen_presentation0.95703317
84MP0003315_abnormal_perineum_morphology0.93950208
85MP0005666_abnormal_adipose_tissue0.93728022
86MP0001663_abnormal_digestive_system0.92788878
87MP0003091_abnormal_cell_migration0.91515594
88MP0009765_abnormal_xenobiotic_induced0.91301679
89MP0009785_altered_susceptibility_to0.90991591
90MP0008874_decreased_physiological_sensi0.89448766
91MP0008004_abnormal_stomach_pH0.89304065
92MP0003718_maternal_effect0.89022024
93MP0005166_decreased_susceptibility_to0.86380930
94MP0005220_abnormal_exocrine_pancreas0.85964005
95MP0003866_abnormal_defecation0.83856892
96MP0002998_abnormal_bone_remodeling0.83364366
97MP0002876_abnormal_thyroid_physiology0.82968113
98MP0002419_abnormal_innate_immunity0.80266518
99MP0009642_abnormal_blood_homeostasis0.78879966
100MP0005084_abnormal_gallbladder_morpholo0.78542657
101MP0003075_altered_response_to0.78534009
102MP0001853_heart_inflammation0.78409566
103MP0005025_abnormal_response_to0.78387393
104MP0002822_catalepsy0.76909284
105MP0005636_abnormal_mineral_homeostasis0.76114920
106MP0001849_ear_inflammation0.74289806
107MP0002060_abnormal_skin_morphology0.73103682
108MP0009278_abnormal_bone_marrow0.69818192
109MP0000703_abnormal_thymus_morphology0.68961661
110MP0001851_eye_inflammation0.68878576
111MP0009379_abnormal_foot_pigmentation0.68721267
112MP0000579_abnormal_nail_morphology0.68248740
113MP0003566_abnormal_cell_adhesion0.67929910
114MP0010368_abnormal_lymphatic_system0.67697053
115MP0005376_homeostasis/metabolism_phenot0.66906744
116MP0005334_abnormal_fat_pad0.66391054
117MP0001845_abnormal_inflammatory_respons0.64843944
118MP0000427_abnormal_hair_cycle0.63580678
119MP0006292_abnormal_olfactory_placode0.58186696
120MP0006036_abnormal_mitochondrial_physio0.57766944
121MP0002098_abnormal_vibrissa_morphology0.57647857
122MP0006082_CNS_inflammation0.57449077
123MP0005395_other_phenotype0.56305479
124MP0002396_abnormal_hematopoietic_system0.56062352
125MP0001119_abnormal_female_reproductive0.55066818
126MP0002928_abnormal_bile_duct0.54461974
127MP0002971_abnormal_brown_adipose0.53763391
128MP0001800_abnormal_humoral_immune0.53532924
129MP0010155_abnormal_intestine_physiology0.52121852
130MP0002102_abnormal_ear_morphology0.51609067
131MP0008058_abnormal_DNA_repair0.50413191
132MP0000383_abnormal_hair_follicle0.49961187
133MP0005397_hematopoietic_system_phenotyp0.49329636
134MP0001545_abnormal_hematopoietic_system0.49329636
135MP0002249_abnormal_larynx_morphology0.49253951
136MP0002078_abnormal_glucose_homeostasis0.47777807
137MP0009053_abnormal_anal_canal0.46888310
138MP0002796_impaired_skin_barrier0.46360719
139MP0002136_abnormal_kidney_physiology0.46163358
140MP0000371_diluted_coat_color0.45846204
141MP0002148_abnormal_hypersensitivity_rea0.45763956
142MP0003693_abnormal_embryo_hatching0.44046964
143MP0002723_abnormal_immune_serum0.43737906
144MP0005266_abnormal_metabolism0.43170166
145MP0001661_extended_life_span0.42901210
146MP0001243_abnormal_dermal_layer0.42876833
147MP0003453_abnormal_keratinocyte_physiol0.42385794
148MP0003638_abnormal_response/metabolism_0.42046364
149MP0002277_abnormal_respiratory_mucosa0.41182911
150MP0001216_abnormal_epidermal_layer0.39235476
151MP0000639_abnormal_adrenal_gland0.39232742
152MP0000490_abnormal_crypts_of0.39020383
153MP0009115_abnormal_fat_cell0.38102674
154MP0005448_abnormal_energy_balance0.37760133

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.50969390
2Intrahepatic cholestasis (HP:0001406)6.41562889
3Prolonged partial thromboplastin time (HP:0003645)6.19310906
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.00289538
5Deep venous thrombosis (HP:0002625)5.74963342
6Hypobetalipoproteinemia (HP:0003563)5.54934348
7Joint hemorrhage (HP:0005261)5.20640463
8Xanthomatosis (HP:0000991)5.09141278
9Hyperlipoproteinemia (HP:0010980)4.71857164
10Complement deficiency (HP:0004431)4.66876412
11Abnormality of pyrimidine metabolism (HP:0004353)4.61018374
12Abnormality of methionine metabolism (HP:0010901)4.08312348
13Hypolipoproteinemia (HP:0010981)4.06519657
14Purpura (HP:0000979)4.02692650
15Conjugated hyperbilirubinemia (HP:0002908)3.90157322
16Hyperammonemia (HP:0001987)3.85349334
17Epidermoid cyst (HP:0200040)3.82793328
18Broad distal phalanx of finger (HP:0009836)3.82418271
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.81502232
20Fat malabsorption (HP:0002630)3.75478134
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.75224367
22Abnormality of the common coagulation pathway (HP:0010990)3.72199074
23Hyperglycinemia (HP:0002154)3.70714970
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.67931063
25Abnormality of complement system (HP:0005339)3.64102043
26Petechiae (HP:0000967)3.62232236
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.62205280
28Gastrointestinal stroma tumor (HP:0100723)3.54200929
29Hyperglycinuria (HP:0003108)3.50372267
30Abnormality of macrophages (HP:0004311)3.48944240
31Eczematoid dermatitis (HP:0000976)3.48236316
32Abnormality of the intrinsic pathway (HP:0010989)3.48189631
33Hypoalphalipoproteinemia (HP:0003233)3.47754195
34Prolonged bleeding time (HP:0003010)3.38919863
35Short nail (HP:0001799)3.33816273
36Abnormality of glycine metabolism (HP:0010895)3.31301678
37Abnormality of serine family amino acid metabolism (HP:0010894)3.31301678
38Hypoglycemic coma (HP:0001325)3.21975949
39Ketosis (HP:0001946)3.21506796
40Hypercholesterolemia (HP:0003124)3.20385517
41Recurrent bacterial skin infections (HP:0005406)3.15561098
42Agammaglobulinemia (HP:0004432)3.07489744
43Systemic lupus erythematosus (HP:0002725)3.06400243
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04752469
45Abnormality of fatty-acid metabolism (HP:0004359)3.04006013
46Colitis (HP:0002583)3.02150791
47Steatorrhea (HP:0002570)3.01255621
48Hyperbilirubinemia (HP:0002904)3.00616914
49Recurrent abscess formation (HP:0002722)3.00417209
50Abnormality of nucleobase metabolism (HP:0010932)3.00348800
51Myocardial infarction (HP:0001658)2.98036998
52Renal cortical cysts (HP:0000803)2.93197750
53Gingivitis (HP:0000230)2.91601161
54Recurrent sinusitis (HP:0011108)2.91549369
55Recurrent gram-negative bacterial infections (HP:0005420)2.91296960
56Abnormality of liposaccharide metabolism (HP:0010968)2.81985421
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.81985421
58Abnormality of glycolipid metabolism (HP:0010969)2.81985421
59Abnormality of serum amino acid levels (HP:0003112)2.81945658
60Dysostosis multiplex (HP:0000943)2.81375274
61Delayed CNS myelination (HP:0002188)2.80752967
62Meningitis (HP:0001287)2.80488492
63Glomerulonephritis (HP:0000099)2.79414972
64Cellulitis (HP:0100658)2.74536459
65Nasal polyposis (HP:0100582)2.72846177
66Chronic obstructive pulmonary disease (HP:0006510)2.70480862
67Obstructive lung disease (HP:0006536)2.70480862
68Emphysema (HP:0002097)2.67735395
69Gingival bleeding (HP:0000225)2.63165995
70Hepatocellular carcinoma (HP:0001402)2.62572721
71Vascular calcification (HP:0004934)2.61496614
7211 pairs of ribs (HP:0000878)2.57350189
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56636006
74Dicarboxylic aciduria (HP:0003215)2.56636006
75Abnormal platelet volume (HP:0011876)2.53143771
76Increased cerebral lipofuscin (HP:0011813)2.51888642
77Recurrent pneumonia (HP:0006532)2.51527646
78Mediastinal lymphadenopathy (HP:0100721)2.51488138
79Hemorrhage of the eye (HP:0011885)2.50218019
80Inflammation of the large intestine (HP:0002037)2.50039948
81Abnormality of the nasal mucosa (HP:0000433)2.48212932
82Gastrointestinal inflammation (HP:0004386)2.46317813
83Hypochromic microcytic anemia (HP:0004840)2.46254151
84Vasculitis (HP:0002633)2.43748835
85Vacuolated lymphocytes (HP:0001922)2.40010057
86Metabolic acidosis (HP:0001942)2.37389243
87Menorrhagia (HP:0000132)2.37318283
88Spinal cord compression (HP:0002176)2.37000456
89Opisthotonus (HP:0002179)2.33633876
90Increased mean platelet volume (HP:0011877)2.33216905
91Prolonged neonatal jaundice (HP:0006579)2.33133143
92Increased serum ferritin (HP:0003281)2.32919196
93Lethargy (HP:0001254)2.31351006
94Pancreatitis (HP:0001733)2.28591847
95Recurrent viral infections (HP:0004429)2.28584683
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.27420125
97Recurrent bronchitis (HP:0002837)2.26233816
98Reduced antithrombin III activity (HP:0001976)2.23864958
99Recurrent lower respiratory tract infections (HP:0002783)2.22997995
100Spontaneous abortion (HP:0005268)2.21256950
101Cardiovascular calcification (HP:0011915)2.20348546
102Pathologic fracture (HP:0002756)2.20333868
103Abnormality of purine metabolism (HP:0004352)2.20014013
104Enlarged kidneys (HP:0000105)2.18641534
105Hypoglycemic seizures (HP:0002173)2.17212115
106Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17051121
107Myositis (HP:0100614)2.16666734
108Cerebral edema (HP:0002181)2.15789107
109Generalized aminoaciduria (HP:0002909)2.14562506
110Asymmetric septal hypertrophy (HP:0001670)2.13946465
111Cupped ribs (HP:0000887)2.13068691
112Impaired platelet aggregation (HP:0003540)2.12605831
113Abnormal platelet function (HP:0011869)2.12605831
114Acanthocytosis (HP:0001927)2.12568667
115Malnutrition (HP:0004395)2.11280520
116Recurrent skin infections (HP:0001581)2.08318974
117Severe visual impairment (HP:0001141)2.07949988
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07896488
119Cholecystitis (HP:0001082)2.07389239
120Abnormal gallbladder physiology (HP:0012438)2.07389239
121Abnormal biliary tract physiology (HP:0012439)2.05635033
122Bile duct proliferation (HP:0001408)2.05635033
123Ovoid vertebral bodies (HP:0003300)2.04297256
124Chromsome breakage (HP:0040012)2.02533600
125Orchitis (HP:0100796)2.01845418
126Thrombophlebitis (HP:0004418)2.00775373
127Nausea (HP:0002018)2.00378384
128Abnormal delayed hypersensitivity skin test (HP:0002963)1.99092736
129Hypophosphatemic rickets (HP:0004912)1.99080327
130Recurrent fungal infections (HP:0002841)1.97099357
131Abnormality of the prostate (HP:0008775)1.96705166
132Abnormality of iron homeostasis (HP:0011031)1.96585673
133Arterial thrombosis (HP:0004420)1.96223500
134Elevated hepatic transaminases (HP:0002910)1.96026703
135Centrally nucleated skeletal muscle fibers (HP:0003687)1.94682593
136Retrobulbar optic neuritis (HP:0100654)1.93888056
137Optic neuritis (HP:0100653)1.93888056
138Epistaxis (HP:0000421)1.93868213
139Fair hair (HP:0002286)1.93677461
140Encephalitis (HP:0002383)1.93654038
141Ketoacidosis (HP:0001993)1.93360833
142IgA deficiency (HP:0002720)1.93360675
143Elevated erythrocyte sedimentation rate (HP:0003565)1.92681104
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92392223
145Abnormality of polysaccharide metabolism (HP:0011012)1.92392223
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92392223
147Fragile skin (HP:0001030)1.92242357
148Flared iliac wings (HP:0002869)1.91588358
149Restrictive lung disease (HP:0002091)1.91226644
150Mucopolysacchariduria (HP:0008155)1.91156038
151Urinary glycosaminoglycan excretion (HP:0003541)1.91156038
152Spastic diplegia (HP:0001264)1.90971861
153Cerebral palsy (HP:0100021)1.88469646
154Proximal tubulopathy (HP:0000114)1.87735509
155Recurrent cutaneous fungal infections (HP:0011370)1.87471554
156Chronic mucocutaneous candidiasis (HP:0002728)1.87471554
157Thoracic kyphosis (HP:0002942)1.87092143
158Abnormality of carpal bone ossification (HP:0006257)1.85077642
159Brushfield spots (HP:0001088)1.84507992
160Lymphopenia (HP:0001888)1.84270078
161Thin bony cortex (HP:0002753)1.83868925
162Abnormality of transition element cation homeostasis (HP:0011030)1.82926099
163Bicuspid aortic valve (HP:0001647)1.82678640
164Cardiomegaly (HP:0001640)1.81680351
165Rickets (HP:0002748)1.81657531
166Nephritis (HP:0000123)1.80974339
167Amyloidosis (HP:0011034)1.80763650
168Mitral stenosis (HP:0001718)1.80282439
169Abnormal enzyme/coenzyme activity (HP:0012379)1.79733802
170Poikilocytosis (HP:0004447)1.78598701
171Esophageal varix (HP:0002040)1.75724173
172Abnormality of proline metabolism (HP:0010907)1.71882938
173Hydroxyprolinuria (HP:0003080)1.71882938
174Elevated alkaline phosphatase (HP:0003155)1.71001484
175Hypertriglyceridemia (HP:0002155)1.70747973
176Vomiting (HP:0002013)1.68246011
177Skin nodule (HP:0200036)1.68023031
178Glycosuria (HP:0003076)1.66789914
179Abnormality of urine glucose concentration (HP:0011016)1.66789914
180Irritability (HP:0000737)1.65668626
181Neonatal hypoglycemia (HP:0001998)1.65610191
182Late onset (HP:0003584)1.65509006

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.35853011
2TRIB33.48560844
3IRAK33.31831734
4RIPK43.22446831
5TAOK32.94186889
6PRPF4B2.82654822
7SMG12.80066959
8STK162.66729231
9SIK12.55633546
10FLT32.37632298
11INSRR2.33622659
12FGFR42.18676207
13MAP3K142.03697192
14EIF2AK22.01374872
15IRAK41.98624710
16ZAK1.98590817
17BLK1.90322051
18TAOK11.83034326
19KSR21.79807442
20EPHB11.75787867
21MAP3K11.74724030
22DDR21.73773928
23MST1R1.67012727
24GRK11.64045154
25TXK1.60773809
26MAP3K131.60473169
27TEC1.58196089
28ERN11.57305865
29TESK11.56670018
30ERBB41.56213427
31FRK1.52010498
32PIK3CG1.48082508
33LATS11.46609099
34TESK21.46234392
35TYK21.36625430
36SYK1.34489600
37KIT1.32524623
38IKBKE1.31079704
39TTK1.30266108
40MKNK21.28291838
41STK38L1.27730261
42MAPK111.26380647
43CDC42BPA1.24995753
44NME21.24334803
45TBK11.21797400
46ICK1.17713073
47PRKD31.17567893
48MARK21.17423844
49TNK21.16171266
50NEK91.14695713
51BTK1.12404861
52CSF1R1.11166717
53ADRBK21.10831355
54ACVR1B1.09648902
55MAP2K31.07221677
56PRKD21.07215348
57NLK1.06758741
58PDPK11.04110778
59IKBKB1.03561654
60KDR1.02696523
61TIE11.01760635
62PKN21.01395021
63TLK11.01289227
64FES0.99540126
65MAP3K80.99237987
66ARAF0.98746916
67GRK60.98637467
68BMX0.98283303
69RIPK10.96814555
70MATK0.94706559
71SIK30.93644080
72TGFBR20.91160428
73EPHA20.91141194
74PRKAA20.91121654
75JAK10.90814965
76PDK10.89918948
77EEF2K0.89898705
78PLK40.89840536
79MAP3K60.89329908
80CLK10.88106090
81TAOK20.88011941
82PBK0.87632890
83MAP4K10.87083087
84IRAK10.86612595
85NUAK10.82484298
86RPS6KA40.81870791
87TAF10.81667806
88MAP2K60.80878028
89ABL20.80490828
90MAP3K30.77566588
91YES10.76078631
92JAK30.74444328
93EIF2AK10.74092735
94DYRK1B0.73872783
95HCK0.73010977
96EPHA30.72411859
97DAPK30.72160520
98EIF2AK30.71428400
99CHUK0.69973489
100MAPK40.69192757
101RAF10.68519278
102LYN0.67900692
103MAPK150.67806859
104SIK20.66208022
105STK30.65644256
106PIM10.65032715
107ATR0.64830575
108MKNK10.64762710
109CAMK1D0.64302991
110EPHB20.64272401
111RPS6KA20.64239439
112JAK20.64215303
113BMPR20.63582390
114FGR0.63349370
115MAP3K110.63101683
116CDK60.62385186
117CDK40.62321924
118TTN0.61729552
119ZAP700.60388887
120STK380.60139899
121RET0.60017589
122CDK70.58750790
123CSK0.58713247
124BRSK20.56714020
125VRK10.56603336
126LCK0.56024636
127MAPK120.54899389
128KSR10.54487714
129MAPK70.53825013
130SRPK10.52960123
131PIM20.51086686
132PRKCQ0.51029890
133ERBB20.50831076
134STK40.50089644
135PTK2B0.49267640
136PINK10.48119586
137MAP3K20.47430524
138AKT30.45102129
139SGK20.44781813
140MAPKAPK30.44606992
141ILK0.44204266
142IRAK20.43707144
143GRK70.43556375
144MAP3K100.42959138
145FGFR20.42947048
146CSNK2A10.41548590
147DYRK30.40483251
148BRAF0.40182590
149PTK60.39833741
150CAMKK10.39816867
151ITK0.39802050
152FGFR30.39599143
153PLK10.39179328
154LRRK20.38001495
155MAP2K10.37937985
156MTOR0.37840370
157PAK10.37221801
158CDK120.33977177
159WNK10.33855634
160HIPK20.33328288
161TYRO30.32528910

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.07866270
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34454444
3Complement and coagulation cascades_Homo sapiens_hsa046102.63335224
4Allograft rejection_Homo sapiens_hsa053302.56325915
5Tryptophan metabolism_Homo sapiens_hsa003802.56309153
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.54967589
7Arginine biosynthesis_Homo sapiens_hsa002202.47727047
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.40467724
9Nitrogen metabolism_Homo sapiens_hsa009102.36765229
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33448235
11Autoimmune thyroid disease_Homo sapiens_hsa053202.29510085
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.28552735
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27144798
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.24123874
15Fatty acid degradation_Homo sapiens_hsa000712.21626928
16B cell receptor signaling pathway_Homo sapiens_hsa046622.21208721
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17729462
18Staphylococcus aureus infection_Homo sapiens_hsa051502.14012082
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.12626820
20Histidine metabolism_Homo sapiens_hsa003402.12385279
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.10840924
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10322092
23Chemical carcinogenesis_Homo sapiens_hsa052042.10025056
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.09471096
25* Peroxisome_Homo sapiens_hsa041462.05837276
26Drug metabolism - other enzymes_Homo sapiens_hsa009832.04917518
27Graft-versus-host disease_Homo sapiens_hsa053322.04864707
28Leishmaniasis_Homo sapiens_hsa051401.99998126
29Caffeine metabolism_Homo sapiens_hsa002321.99749040
30Retinol metabolism_Homo sapiens_hsa008301.99509295
31beta-Alanine metabolism_Homo sapiens_hsa004101.92030687
32Primary immunodeficiency_Homo sapiens_hsa053401.87347677
33Selenocompound metabolism_Homo sapiens_hsa004501.74072258
34Asthma_Homo sapiens_hsa053101.71915655
35Propanoate metabolism_Homo sapiens_hsa006401.71121390
36One carbon pool by folate_Homo sapiens_hsa006701.68322284
37PPAR signaling pathway_Homo sapiens_hsa033201.63300993
38Type I diabetes mellitus_Homo sapiens_hsa049401.63195577
39Folate biosynthesis_Homo sapiens_hsa007901.61249709
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60619970
41Butanoate metabolism_Homo sapiens_hsa006501.57545847
42Fatty acid metabolism_Homo sapiens_hsa012121.52287263
43Viral myocarditis_Homo sapiens_hsa054161.51679884
44Phenylalanine metabolism_Homo sapiens_hsa003601.49156425
45Osteoclast differentiation_Homo sapiens_hsa043801.44845772
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41428275
47Starch and sucrose metabolism_Homo sapiens_hsa005001.38023605
48Tyrosine metabolism_Homo sapiens_hsa003501.37828145
49Fatty acid elongation_Homo sapiens_hsa000621.36158314
50ABC transporters_Homo sapiens_hsa020101.34101352
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.30886333
52Influenza A_Homo sapiens_hsa051641.30532868
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27846046
54Tuberculosis_Homo sapiens_hsa051521.25531968
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25507431
56Lysosome_Homo sapiens_hsa041421.24406699
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.24016626
58Steroid biosynthesis_Homo sapiens_hsa001001.22524977
59Acute myeloid leukemia_Homo sapiens_hsa052211.20584287
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20168802
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.15796443
62Sulfur metabolism_Homo sapiens_hsa009201.14834385
63Antigen processing and presentation_Homo sapiens_hsa046121.14314843
64Toxoplasmosis_Homo sapiens_hsa051451.13497049
65Vitamin digestion and absorption_Homo sapiens_hsa049771.10846047
66Sulfur relay system_Homo sapiens_hsa041221.10291769
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06642043
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03831223
69Platelet activation_Homo sapiens_hsa046111.02040672
70Fat digestion and absorption_Homo sapiens_hsa049751.01801311
71Arginine and proline metabolism_Homo sapiens_hsa003300.99235033
72Pyruvate metabolism_Homo sapiens_hsa006200.96371094
73Bile secretion_Homo sapiens_hsa049760.96240469
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93562246
75Biosynthesis of amino acids_Homo sapiens_hsa012300.93465051
76Vitamin B6 metabolism_Homo sapiens_hsa007500.90533257
77Chemokine signaling pathway_Homo sapiens_hsa040620.88706879
78Lysine degradation_Homo sapiens_hsa003100.88392273
79Phagosome_Homo sapiens_hsa041450.85934878
80TNF signaling pathway_Homo sapiens_hsa046680.84543002
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.82971917
82Glutathione metabolism_Homo sapiens_hsa004800.81563768
83Carbon metabolism_Homo sapiens_hsa012000.79661364
84Prion diseases_Homo sapiens_hsa050200.78969559
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70687069
86Endocytosis_Homo sapiens_hsa041440.70239108
87Apoptosis_Homo sapiens_hsa042100.69008262
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67789379
89Pentose phosphate pathway_Homo sapiens_hsa000300.63525550
90Measles_Homo sapiens_hsa051620.62085125
91Bladder cancer_Homo sapiens_hsa052190.60930582
92Hepatitis C_Homo sapiens_hsa051600.60575124
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60497866
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60012346
95VEGF signaling pathway_Homo sapiens_hsa043700.58242789
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58148406
97T cell receptor signaling pathway_Homo sapiens_hsa046600.57665471
98Metabolic pathways_Homo sapiens_hsa011000.57296667
99Sphingolipid metabolism_Homo sapiens_hsa006000.55153115
100Hepatitis B_Homo sapiens_hsa051610.54799422
101Malaria_Homo sapiens_hsa051440.54694950
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54471130
103Glycerolipid metabolism_Homo sapiens_hsa005610.54300093
104Notch signaling pathway_Homo sapiens_hsa043300.49739639
105Viral carcinogenesis_Homo sapiens_hsa052030.48333429
106Rheumatoid arthritis_Homo sapiens_hsa053230.48170738
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48089643
108Renin-angiotensin system_Homo sapiens_hsa046140.47278721
109Linoleic acid metabolism_Homo sapiens_hsa005910.47020586
110Shigellosis_Homo sapiens_hsa051310.45676827
111Homologous recombination_Homo sapiens_hsa034400.43276302
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43150776
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43111917
114Fatty acid biosynthesis_Homo sapiens_hsa000610.42971884
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42616917
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42524566
117Pyrimidine metabolism_Homo sapiens_hsa002400.42516743
118Galactose metabolism_Homo sapiens_hsa000520.36502424
119DNA replication_Homo sapiens_hsa030300.35210776
120Fanconi anemia pathway_Homo sapiens_hsa034600.34070968
121Arachidonic acid metabolism_Homo sapiens_hsa005900.33388682
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33109094
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.29387092
124Mismatch repair_Homo sapiens_hsa034300.29208665
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23902017
126Base excision repair_Homo sapiens_hsa034100.23803411
127Fructose and mannose metabolism_Homo sapiens_hsa000510.19158018
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.16887834
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.15199614
130Other glycan degradation_Homo sapiens_hsa005110.14896999
131Non-homologous end-joining_Homo sapiens_hsa034500.12192047
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.11623909
133Ribosome_Homo sapiens_hsa030100.11420387
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.11188448
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.11136284
136Systemic lupus erythematosus_Homo sapiens_hsa053220.08877408
137Legionellosis_Homo sapiens_hsa051340.07932291
138Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.07835764
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07242385
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.05859302
141Herpes simplex infection_Homo sapiens_hsa051680.04977884
142Hematopoietic cell lineage_Homo sapiens_hsa046400.03300573
143Pertussis_Homo sapiens_hsa051330.03130596
144Insulin resistance_Homo sapiens_hsa049310.02582699
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.01847277
146Regulation of autophagy_Homo sapiens_hsa041400.01042658

Most similar genes based on co-expression Upload to Enrichr

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