PAPD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23825967
2positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.85294083
3germinal center formation (GO:0002467)3.80739963
4regulation of gamma-delta T cell activation (GO:0046643)3.80202923
5regulation of T-helper 1 cell differentiation (GO:0045625)3.50565749
6regulation of germinal center formation (GO:0002634)3.44387302
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.43680179
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.43680179
9cellular response to ethanol (GO:0071361)3.39357289
10immunoglobulin mediated immune response (GO:0016064)3.35605372
11macrophage activation involved in immune response (GO:0002281)3.33528262
12negative regulation of cell killing (GO:0031342)3.30375820
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.30375820
14positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.25193359
15antigen processing and presentation of endogenous antigen (GO:0019883)3.24495374
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23818839
17B cell receptor signaling pathway (GO:0050853)3.22161700
18regulation of alpha-beta T cell proliferation (GO:0046640)3.19310117
19positive regulation of granulocyte differentiation (GO:0030854)3.18545985
20positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14625570
21interferon-gamma-mediated signaling pathway (GO:0060333)3.13588049
22response to protozoan (GO:0001562)3.11123382
23negative regulation of T cell mediated immunity (GO:0002710)3.05168003
24mitotic nuclear envelope disassembly (GO:0007077)3.04860126
25defense response to protozoan (GO:0042832)3.04656876
26lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02500561
27positive regulation of interferon-alpha production (GO:0032727)3.01785282
28T-helper 1 type immune response (GO:0042088)3.00945821
29B cell mediated immunity (GO:0019724)2.99390363
30protein localization to kinetochore (GO:0034501)2.97045168
31positive regulation of gamma-delta T cell activation (GO:0046645)2.93028990
32Arp2/3 complex-mediated actin nucleation (GO:0034314)2.88777128
33regulation of RIG-I signaling pathway (GO:0039535)2.88736278
34myeloid cell activation involved in immune response (GO:0002275)2.87507792
35definitive hemopoiesis (GO:0060216)2.86133158
36positive regulation of interleukin-2 production (GO:0032743)2.86066846
37regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.85486819
38regulation of interferon-alpha production (GO:0032647)2.85440700
39nuclear envelope disassembly (GO:0051081)2.83843699
40membrane disassembly (GO:0030397)2.83843699
41detection of molecule of bacterial origin (GO:0032490)2.83806064
42positive regulation by symbiont of host defense response (GO:0052509)2.82948178
43modulation by symbiont of host defense response (GO:0052031)2.82948178
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82948178
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82948178
46positive regulation by organism of defense response of other organism involved in symbiotic interact2.82948178
47modulation by symbiont of host immune response (GO:0052553)2.82948178
48positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.81733458
49peptide catabolic process (GO:0043171)2.80499936
50NIK/NF-kappaB signaling (GO:0038061)2.77819849
51negative thymic T cell selection (GO:0045060)2.76939281
52regulation of T-helper cell differentiation (GO:0045622)2.76790622
53detection of other organism (GO:0098543)2.76398130
54regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.75901235
55T-helper cell differentiation (GO:0042093)2.74951369
56CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.74951369
57folic acid-containing compound biosynthetic process (GO:0009396)2.74845997
58positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.73168602
59natural killer cell mediated cytotoxicity (GO:0042267)2.71900476
60natural killer cell mediated immunity (GO:0002228)2.71900476
61neutrophil activation involved in immune response (GO:0002283)2.71630954
62B cell homeostasis (GO:0001782)2.71629739
63regulation of T cell tolerance induction (GO:0002664)2.71127675
64regulation of interleukin-8 biosynthetic process (GO:0045414)2.71009038
65interferon-gamma secretion (GO:0072643)2.70851076
66negative regulation of B cell proliferation (GO:0030889)2.70706816
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.69859095
68negative regulation of T-helper cell differentiation (GO:0045623)2.69859095
69negative regulation of cytokine production involved in immune response (GO:0002719)2.67244030
70positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.66606276
71protein K11-linked deubiquitination (GO:0035871)2.66342988
72negative T cell selection (GO:0043383)2.65934426
73mitotic metaphase plate congression (GO:0007080)2.65256961
74positive regulation of mast cell activation (GO:0033005)2.63350039
75protein localization to chromosome, centromeric region (GO:0071459)2.63195425
76regulation of vitamin D biosynthetic process (GO:0060556)2.62620054
77positive regulation of type 2 immune response (GO:0002830)2.62619469
78regulation of cytokine secretion involved in immune response (GO:0002739)2.61678410
79regulation of tolerance induction (GO:0002643)2.60715088
80formation of translation preinitiation complex (GO:0001731)2.60048901
81response to interleukin-15 (GO:0070672)2.57739875
82positive regulation of interferon-beta production (GO:0032728)2.57465345
83T cell activation involved in immune response (GO:0002286)2.57355233
84regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.56817074
85regulation of interleukin-2 biosynthetic process (GO:0045076)2.56292416
86interferon-gamma production (GO:0032609)2.54325761
87regulation of chronic inflammatory response (GO:0002676)2.54288471
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.54212819
89cellular response to interferon-gamma (GO:0071346)2.53586593
90regulation of interleukin-12 production (GO:0032655)2.53207472
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.52463262
92positive regulation of DNA recombination (GO:0045911)2.52078483
93neutrophil mediated immunity (GO:0002446)2.51823157
94macrophage activation (GO:0042116)2.51623713
95adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.51459836
96DNA strand elongation involved in DNA replication (GO:0006271)2.50076426
97regulation of interferon-beta biosynthetic process (GO:0045357)2.47770666
98nuclear pore complex assembly (GO:0051292)2.47687251
99regulation of spindle organization (GO:0090224)2.47203600
100response to interferon-alpha (GO:0035455)2.46444369
101DNA unwinding involved in DNA replication (GO:0006268)2.46004021
102nuclear pore organization (GO:0006999)2.45918188
1033-UTR-mediated mRNA stabilization (GO:0070935)2.45577287
104positive regulation of B cell differentiation (GO:0045579)2.44924880
105T cell migration (GO:0072678)2.43730219
106cellular response to type I interferon (GO:0071357)2.43019719
107type I interferon signaling pathway (GO:0060337)2.43019719
108regulation of interleukin-12 biosynthetic process (GO:0045075)2.42959645
109positive regulation of protein import into nucleus, translocation (GO:0033160)2.42694614
110response to type I interferon (GO:0034340)2.42498971
111antigen processing and presentation via MHC class Ib (GO:0002475)2.41780786
112DNA strand elongation (GO:0022616)2.41512743
113mitotic chromosome condensation (GO:0007076)2.39487502
114respiratory burst (GO:0045730)2.38694128
115DNA replication initiation (GO:0006270)2.37615731
116DNA deamination (GO:0045006)2.34876735
117folic acid metabolic process (GO:0046655)2.34026722
118cellular extravasation (GO:0045123)2.33311298
119myeloid dendritic cell differentiation (GO:0043011)2.33246619
120response to peptidoglycan (GO:0032494)2.32741509
121myeloid dendritic cell activation (GO:0001773)2.32006256
122regulation of B cell differentiation (GO:0045577)2.31970610
123telomere maintenance via semi-conservative replication (GO:0032201)2.31135591
124response to muramyl dipeptide (GO:0032495)2.31111417
125regulation of B cell receptor signaling pathway (GO:0050855)2.30786727
126regulation of mononuclear cell migration (GO:0071675)2.30583117
127positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.28285857
128telomere maintenance via recombination (GO:0000722)2.27019593
129regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.25978441
130negative regulation of interleukin-12 production (GO:0032695)2.25969710
131T cell apoptotic process (GO:0070231)2.25771056
132establishment of chromosome localization (GO:0051303)2.25445355
133positive regulation of T cell apoptotic process (GO:0070234)2.24199642
134pinocytosis (GO:0006907)2.23956859
135DNA replication checkpoint (GO:0000076)2.23189949
136positive regulation of natural killer cell differentiation (GO:0032825)2.22954971
137regulation of type I interferon-mediated signaling pathway (GO:0060338)2.21973016
138nuclear envelope organization (GO:0006998)2.21808089
139DNA replication-independent nucleosome organization (GO:0034724)2.21260007
140DNA replication-independent nucleosome assembly (GO:0006336)2.21260007
141metaphase plate congression (GO:0051310)2.21136128
142positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.19289542
143purine nucleobase biosynthetic process (GO:0009113)2.18642506
144natural killer cell differentiation (GO:0001779)2.17776427
145mitotic recombination (GO:0006312)2.16580575
146CENP-A containing nucleosome assembly (GO:0034080)2.16281976
147granulocyte activation (GO:0036230)2.16157718
148ribosomal small subunit assembly (GO:0000028)2.15905449
149nucleobase biosynthetic process (GO:0046112)2.14695470
150regulation of response to interferon-gamma (GO:0060330)2.12718819
151DNA topological change (GO:0006265)2.12359137
152hepatocyte apoptotic process (GO:0097284)2.12029961
153neutrophil activation (GO:0042119)2.11529416
154actin nucleation (GO:0045010)2.11313083
155regulation of protein import into nucleus, translocation (GO:0033158)2.09514202
156attachment of spindle microtubules to kinetochore (GO:0008608)2.09007855
157regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.08818307
158regulation of gamma-delta T cell differentiation (GO:0045586)2.08429322
159response to interferon-beta (GO:0035456)2.07399145
160regulation of interferon-beta production (GO:0032648)2.06935480
161cellular response to interferon-beta (GO:0035458)2.06693169
162chromatin remodeling at centromere (GO:0031055)2.06208490
163DNA replication-dependent nucleosome assembly (GO:0006335)2.05237322
164DNA replication-dependent nucleosome organization (GO:0034723)2.05237322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.47828969
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.41934341
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.41235274
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.32508967
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.99459945
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86793776
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.82677451
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.67133449
9* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.61224527
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.53494250
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32444209
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31943968
13MYC_22102868_ChIP-Seq_BL_Human2.30517719
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21941295
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15859314
16ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.12934586
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11869220
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10644908
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04464044
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00581814
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98158969
22RUNX_20019798_ChIP-Seq_JUKART_Human1.95241921
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91194147
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86572940
25VDR_24787735_ChIP-Seq_THP-1_Human1.84276758
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83854459
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.82561793
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82366503
29* SPI1_23547873_ChIP-Seq_NB4_Human1.78471409
30GATA3_26560356_Chip-Seq_TH2_Human1.75450412
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75069293
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74689598
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71700513
34VDR_21846776_ChIP-Seq_THP-1_Human1.71260952
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67792707
36VDR_23849224_ChIP-Seq_CD4+_Human1.65349397
37* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64224819
38* GABP_17652178_ChIP-ChIP_JURKAT_Human1.64011221
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62824422
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.61657282
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61628337
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.58879257
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58788300
44* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58681417
45MYB_26560356_Chip-Seq_TH2_Human1.58385460
46GATA1_22025678_ChIP-Seq_K562_Human1.57044607
47GATA3_27048872_Chip-Seq_THYMUS_Human1.56774302
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56266782
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56099483
50AR_21909140_ChIP-Seq_LNCAP_Human1.55952666
51* EST1_17652178_ChIP-ChIP_JURKAT_Human1.55449906
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54306843
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54129858
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.51058726
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50828671
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.49584778
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49155203
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47667282
59MAF_26560356_Chip-Seq_TH1_Human1.44803374
60MYB_26560356_Chip-Seq_TH1_Human1.44713974
61XRN2_22483619_ChIP-Seq_HELA_Human1.42081034
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.41865146
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39890249
64* SPI1_23127762_ChIP-Seq_K562_Human1.38925883
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.37355135
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.36709982
67* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36707189
68SCL_19346495_ChIP-Seq_HPC-7_Human1.36546803
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36306620
70* TFEB_21752829_ChIP-Seq_HELA_Human1.35404866
71DCP1A_22483619_ChIP-Seq_HELA_Human1.35155108
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34781917
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33189679
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.32835526
75FOXP3_21729870_ChIP-Seq_TREG_Human1.32418535
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30619644
77CIITA_25753668_ChIP-Seq_RAJI_Human1.30131353
78ELK1_19687146_ChIP-ChIP_HELA_Human1.29731938
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29665873
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.29653459
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27525670
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27217035
83* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26699778
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25205197
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25188104
86VDR_24763502_ChIP-Seq_THP-1_Human1.24099518
87EWS_26573619_Chip-Seq_HEK293_Human1.23860727
88IGF1R_20145208_ChIP-Seq_DFB_Human1.23358749
89GABP_19822575_ChIP-Seq_HepG2_Human1.21769647
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20954240
91* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19849617
92* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18322652
93UTX_26944678_Chip-Seq_JUKART_Human1.18113105
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17865255
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15398223
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13636316
97TAF15_26573619_Chip-Seq_HEK293_Human1.13003304
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12876638
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12088881
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11842629
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11661367
102* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11191949
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10166730
104KDM5A_27292631_Chip-Seq_BREAST_Human1.09854393
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09531471
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09520001
107TCF7_22412390_ChIP-Seq_EML_Mouse1.09130280
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.07253290
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.07237845
110SALL4_22934838_ChIP-ChIP_CD34+_Human1.06891820
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05616561
112* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02857889
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02758555
114* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02589130
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01739503
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00849131
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00411038
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00144418
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99948463
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99724571
121OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99337785
122EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99025172
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.98479912
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98424257
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98145009
126ER_23166858_ChIP-Seq_MCF-7_Human0.97676463
127CRX_20693478_ChIP-Seq_RETINA_Mouse0.97393006
128CDX2_22108803_ChIP-Seq_LS180_Human0.95058750
129* PU_27001747_Chip-Seq_BMDM_Mouse0.94993668
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94858675
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94760605
132TTF2_22483619_ChIP-Seq_HELA_Human0.94599291
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94580868
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94286837
135CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92082956
136PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91991913
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91870145
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.91650557
139CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91513147
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91349683
141CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90606941
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90177274
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90177274
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90125929
145FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89808057
146Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89432382
147MAF_26560356_Chip-Seq_TH2_Human0.89152111
148E2F1_18555785_Chip-Seq_ESCs_Mouse0.88443727
149CBP_20019798_ChIP-Seq_JUKART_Human0.88158369
150IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88158369
151GATA3_26560356_Chip-Seq_TH1_Human0.87964313
152CMYC_18555785_Chip-Seq_ESCs_Mouse0.87755053
153SMRT_27268052_Chip-Seq_Bcells_Human0.87204136
154GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86482467
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85819550
156SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85728521
157FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85198876
158FUS_26573619_Chip-Seq_HEK293_Human0.84017518
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82544114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.98130156
2MP0003693_abnormal_embryo_hatching2.77296547
3MP0003436_decreased_susceptibility_to2.67200270
4MP0002396_abnormal_hematopoietic_system2.32517480
5MP0000685_abnormal_immune_system2.18456391
6MP0009785_altered_susceptibility_to2.17414739
7MP0005671_abnormal_response_to2.14805258
8MP0010094_abnormal_chromosome_stability2.13253512
9MP0003111_abnormal_nucleus_morphology2.09255556
10MP0001800_abnormal_humoral_immune2.09119650
11MP0010352_gastrointestinal_tract_polyps2.06904394
12MP0005000_abnormal_immune_tolerance2.05626417
13MP0003077_abnormal_cell_cycle2.02959810
14MP0002452_abnormal_antigen_presenting1.98959662
15MP0004957_abnormal_blastocyst_morpholog1.98569861
16MP0002009_preneoplasia1.93359726
17MP0002138_abnormal_hepatobiliary_system1.92626508
18MP0010307_abnormal_tumor_latency1.89809313
19MP0008007_abnormal_cellular_replicative1.88883777
20MP0002419_abnormal_innate_immunity1.88454846
21MP0005025_abnormal_response_to1.86261556
22MP0003195_calcinosis1.85849301
23MP0008057_abnormal_DNA_replication1.83550655
24MP0002723_abnormal_immune_serum1.81779666
25MP0009333_abnormal_splenocyte_physiolog1.81150912
26MP0002148_abnormal_hypersensitivity_rea1.80586025
27MP0002398_abnormal_bone_marrow1.80300861
28MP0005397_hematopoietic_system_phenotyp1.79742977
29MP0001545_abnormal_hematopoietic_system1.79742977
30MP0001790_abnormal_immune_system1.76853311
31MP0005387_immune_system_phenotype1.76853311
32MP0001819_abnormal_immune_cell1.74260835
33MP0004808_abnormal_hematopoietic_stem1.73669346
34MP0002420_abnormal_adaptive_immunity1.73483014
35MP0000490_abnormal_crypts_of1.72361674
36MP0003303_peritoneal_inflammation1.66228269
37MP0006082_CNS_inflammation1.64516198
38MP0003705_abnormal_hypodermis_morpholog1.63451160
39MP0001853_heart_inflammation1.56348876
40MP0005464_abnormal_platelet_physiology1.55734724
41MP0002405_respiratory_system_inflammati1.55712679
42MP0000689_abnormal_spleen_morphology1.55419629
43MP0003763_abnormal_thymus_physiology1.54819115
44MP0002722_abnormal_immune_system1.54178329
45MP0000716_abnormal_immune_system1.54005156
46MP0009840_abnormal_foam_cell1.45303520
47MP0002429_abnormal_blood_cell1.44714596
48MP0005076_abnormal_cell_differentiation1.44100909
49MP0006054_spinal_hemorrhage1.43428880
50MP0003724_increased_susceptibility_to1.42990887
51MP0002006_tumorigenesis1.42727605
52MP0000858_altered_metastatic_potential1.41387331
53MP0010155_abnormal_intestine_physiology1.41109689
54MP0004947_skin_inflammation1.39909865
55MP0001533_abnormal_skeleton_physiology1.39792912
56MP0001845_abnormal_inflammatory_respons1.35671971
57MP0002166_altered_tumor_susceptibility1.35373775
58MP0002139_abnormal_hepatobiliary_system1.34311754
59MP0009278_abnormal_bone_marrow1.31502993
60MP0005058_abnormal_lysosome_morphology1.28696670
61MP0003448_altered_tumor_morphology1.28304818
62MP0000703_abnormal_thymus_morphology1.26626377
63MP0000350_abnormal_cell_proliferation1.25763310
64MP0008058_abnormal_DNA_repair1.25390598
65MP0002019_abnormal_tumor_incidence1.21624866
66MP0003656_abnormal_erythrocyte_physiolo1.19725767
67MP0003252_abnormal_bile_duct1.19059041
68MP0000015_abnormal_ear_pigmentation1.15775416
69MP0005023_abnormal_wound_healing1.13596344
70MP0003300_gastrointestinal_ulcer1.13540812
71MP0005647_abnormal_sex_gland1.10837571
72MP0008469_abnormal_protein_level1.08101082
73MP0002998_abnormal_bone_remodeling1.07939545
74MP0003566_abnormal_cell_adhesion1.06478511
75MP0004883_abnormal_blood_vessel1.06158838
76MP0003806_abnormal_nucleotide_metabolis1.04669483
77MP0000465_gastrointestinal_hemorrhage1.02401782
78MP0001915_intracranial_hemorrhage1.02100762
79MP0003045_fibrosis1.01667655
80MP0008004_abnormal_stomach_pH1.01646102
81MP0001730_embryonic_growth_arrest1.00444881
82MP0005164_abnormal_response_to0.99381863
83MP0003123_paternal_imprinting0.98463559
84MP0003075_altered_response_to0.96848048
85MP0005167_abnormal_blood-brain_barrier0.96310972
86MP0001873_stomach_inflammation0.95500576
87MP0000343_altered_response_to0.94511033
88MP0005174_abnormal_tail_pigmentation0.93976880
89MP0000313_abnormal_cell_death0.93865493
90MP0001697_abnormal_embryo_size0.93140062
91MP0002086_abnormal_extraembryonic_tissu0.91369367
92MP0003186_abnormal_redox_activity0.88644925
93MP0008932_abnormal_embryonic_tissue0.88576875
94MP0003984_embryonic_growth_retardation0.87545817
95MP0001851_eye_inflammation0.86650826
96MP0002933_joint_inflammation0.86349427
97MP0002088_abnormal_embryonic_growth/wei0.86310516
98MP0004510_myositis0.85623396
99MP0009765_abnormal_xenobiotic_induced0.85614658
100MP0003567_abnormal_fetal_cardiomyocyte0.85569289
101MP0005390_skeleton_phenotype0.85491811
102MP0010386_abnormal_urinary_bladder0.85308255
103MP0009764_decreased_sensitivity_to0.85016630
104MP0000569_abnormal_digit_pigmentation0.84817426
105MP0005380_embryogenesis_phenotype0.84749696
106MP0001672_abnormal_embryogenesis/_devel0.84749696
107MP0003183_abnormal_peptide_metabolism0.82016942
108MP0000371_diluted_coat_color0.81994225
109MP0009763_increased_sensitivity_to0.81898484
110MP0001764_abnormal_homeostasis0.81416455
111MP0000598_abnormal_liver_morphology0.81125365
112MP0002080_prenatal_lethality0.79337416
113MP0005310_abnormal_salivary_gland0.79092242
114MP0008438_abnormal_cutaneous_collagen0.79090123
115MP0002877_abnormal_melanocyte_morpholog0.79061087
116MP0002332_abnormal_exercise_endurance0.78654456
117MP0005166_decreased_susceptibility_to0.78246130
118MP0003172_abnormal_lysosome_physiology0.77585613
119MP0003191_abnormal_cellular_cholesterol0.77047371
120MP0003828_pulmonary_edema0.75787798
121MP0003690_abnormal_glial_cell0.75501150
122MP0002132_abnormal_respiratory_system0.75152614
123MP0002254_reproductive_system_inflammat0.73985684
124MP0003866_abnormal_defecation0.73766203
125MP0002277_abnormal_respiratory_mucosa0.73396812
126MP0005075_abnormal_melanosome_morpholog0.73081830
127MP0003943_abnormal_hepatobiliary_system0.72952419
128MP0003453_abnormal_keratinocyte_physiol0.71743053
129* MP0005621_abnormal_cell_physiology0.71428134
130MP0000609_abnormal_liver_physiology0.70342855
131MP0008260_abnormal_autophagy0.70317111
132MP0002163_abnormal_gland_morphology0.64270193
133MP0000604_amyloidosis0.61749975
134MP0009115_abnormal_fat_cell0.60680287
135MP0001191_abnormal_skin_condition0.59501174
136MP0003091_abnormal_cell_migration0.58989110
137MP0002928_abnormal_bile_duct0.58177126

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.26420509
2Recurrent abscess formation (HP:0002722)3.78023331
3Elevated erythrocyte sedimentation rate (HP:0003565)3.75212611
4Autoimmune hemolytic anemia (HP:0001890)3.72014257
5Recurrent bacterial skin infections (HP:0005406)3.68243882
6Eczematoid dermatitis (HP:0000976)3.54231439
7Abnormality of liposaccharide metabolism (HP:0010968)3.46499102
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.46499102
9Abnormality of glycolipid metabolism (HP:0010969)3.46499102
10Myositis (HP:0100614)3.39084204
11Autoimmune thrombocytopenia (HP:0001973)3.13935308
12Keratoconjunctivitis sicca (HP:0001097)2.98015948
13Pustule (HP:0200039)2.97668491
14Abnormal delayed hypersensitivity skin test (HP:0002963)2.97082755
15Thrombocytosis (HP:0001894)2.95822066
16Recurrent viral infections (HP:0004429)2.94512715
17IgM deficiency (HP:0002850)2.86557705
18Keratoconjunctivitis (HP:0001096)2.81156702
19Agnosia (HP:0010524)2.79706841
20Recurrent fungal infections (HP:0002841)2.75073094
21Recurrent cutaneous fungal infections (HP:0011370)2.74960968
22Chronic mucocutaneous candidiasis (HP:0002728)2.74960968
23Recurrent gram-negative bacterial infections (HP:0005420)2.71334413
24Mediastinal lymphadenopathy (HP:0100721)2.68506365
25Papillary thyroid carcinoma (HP:0002895)2.63619120
26Petechiae (HP:0000967)2.60575262
27Orchitis (HP:0100796)2.59574097
28Chronic diarrhea (HP:0002028)2.58384230
29Hemoptysis (HP:0002105)2.58291073
30Cellulitis (HP:0100658)2.57370059
31Birth length less than 3rd percentile (HP:0003561)2.55815794
32Abnormality of the vasculature of the conjunctiva (HP:0008054)2.47167944
33Systemic lupus erythematosus (HP:0002725)2.43815228
34Abnormality of macrophages (HP:0004311)2.42352951
35Vasculitis (HP:0002633)2.39072404
36Loss of speech (HP:0002371)2.37977024
37Dysostosis multiplex (HP:0000943)2.36998786
38Panhypogammaglobulinemia (HP:0003139)2.36255217
39Inflammation of the large intestine (HP:0002037)2.35921702
40Gangrene (HP:0100758)2.35680993
41Periodontitis (HP:0000704)2.34454447
42Spontaneous hematomas (HP:0007420)2.32534596
43Neoplasm of the tracheobronchial system (HP:0100552)2.27630444
44Increased cerebral lipofuscin (HP:0011813)2.27355605
45Retrobulbar optic neuritis (HP:0100654)2.27289380
46Optic neuritis (HP:0100653)2.27289380
47Chronic otitis media (HP:0000389)2.25174056
48Chest pain (HP:0100749)2.25166403
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.24968977
50Osteolytic defects of the hand bones (HP:0009699)2.24530563
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.24530563
52Joint swelling (HP:0001386)2.23994953
53Poor head control (HP:0002421)2.23563941
54Recurrent skin infections (HP:0001581)2.23017571
55Pulmonary embolism (HP:0002204)2.22487342
56Polyneuropathy (HP:0001271)2.21879104
57Severe combined immunodeficiency (HP:0004430)2.21452381
58Abnormality of T cell physiology (HP:0011840)2.21335911
59Alveolar cell carcinoma (HP:0006519)2.20027574
60Acute myeloid leukemia (HP:0004808)2.19907199
61Abnormality of T cells (HP:0002843)2.19234543
62Leukocytosis (HP:0001974)2.19220369
63Fatigue (HP:0012378)2.15049234
64Lymphoma (HP:0002665)2.13210214
65Recurrent bronchitis (HP:0002837)2.12410657
66Vacuolated lymphocytes (HP:0001922)2.12263983
67Abnormality of the anterior horn cell (HP:0006802)2.10775524
68Degeneration of anterior horn cells (HP:0002398)2.10775524
69Aplastic anemia (HP:0001915)2.10434991
70Chronic obstructive pulmonary disease (HP:0006510)2.07330820
71Obstructive lung disease (HP:0006536)2.07330820
72Abnormality of B cell number (HP:0010975)2.04354778
73B lymphocytopenia (HP:0010976)2.04354778
74Abnormality of chloride homeostasis (HP:0011422)2.04221570
75Peritonitis (HP:0002586)2.03786503
76Arterial thrombosis (HP:0004420)2.03724451
77Azoospermia (HP:0000027)2.03426584
78Thyroiditis (HP:0100646)2.02863429
79Albinism (HP:0001022)2.02241472
80Stomach cancer (HP:0012126)2.02047097
81Abnormality of the fingertips (HP:0001211)2.01960408
82Gastrointestinal inflammation (HP:0004386)2.01842625
83Basal ganglia calcification (HP:0002135)2.00776063
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.00582519
85Widely spaced teeth (HP:0000687)2.00331169
86Lymphopenia (HP:0001888)2.00316332
87Hematochezia (HP:0002573)1.99716739
88Colitis (HP:0002583)1.98115824
89Anhidrosis (HP:0000970)1.97537928
90Abnormal spermatogenesis (HP:0008669)1.97306191
91Conjunctival telangiectasia (HP:0000524)1.95775470
92Volvulus (HP:0002580)1.94921197
93Abnormality of T cell number (HP:0011839)1.94744550
94Vertebral compression fractures (HP:0002953)1.94099431
95Myocardial infarction (HP:0001658)1.93512424
96Increased IgM level (HP:0003496)1.92161973
97T lymphocytopenia (HP:0005403)1.91999773
98Pulmonary fibrosis (HP:0002206)1.91620059
99Gingival bleeding (HP:0000225)1.89716487
100Thyroid carcinoma (HP:0002890)1.88831752
101Combined immunodeficiency (HP:0005387)1.87539980
102Osteomyelitis (HP:0002754)1.87228217
103Pulmonary infiltrates (HP:0002113)1.87110023
104Abnormality of the pleura (HP:0002103)1.87094274
105Meningitis (HP:0001287)1.86249299
106Prolonged bleeding time (HP:0003010)1.85375959
107Eosinophilia (HP:0001880)1.85280746
108Epistaxis (HP:0000421)1.85189928
109IgA deficiency (HP:0002720)1.85117054
110Amaurosis fugax (HP:0100576)1.84582435
111Syringomyelia (HP:0003396)1.84408607
112Spinal cord lesions (HP:0100561)1.84408607
113Interstitial pulmonary disease (HP:0006530)1.82728155
114IgG deficiency (HP:0004315)1.81196324
115Abnormality of the prostate (HP:0008775)1.80802086
116Disinhibition (HP:0000734)1.80685640
117Protrusio acetabuli (HP:0003179)1.80655812
118Increased density of long bones (HP:0006392)1.80526719
119Gastrointestinal infarctions (HP:0005244)1.80443122
120Recurrent pneumonia (HP:0006532)1.78307801
121Emphysema (HP:0002097)1.77802525
122Myelodysplasia (HP:0002863)1.77548938
123Leukopenia (HP:0001882)1.77465286
124Reticulocytopenia (HP:0001896)1.77023257
125Abnormal platelet volume (HP:0011876)1.76287140
126Recurrent lower respiratory tract infections (HP:0002783)1.75725888
127Prostate neoplasm (HP:0100787)1.72321339
128Gingivitis (HP:0000230)1.71632724
129Granulocytopenia (HP:0001913)1.71301827
130Skin ulcer (HP:0200042)1.69977710
131Abnormality of eosinophils (HP:0001879)1.69930251
132Urticaria (HP:0001025)1.68414530
133Anorexia (HP:0002039)1.68408902
134Gastrointestinal stroma tumor (HP:0100723)1.67021944
135Glomerulonephritis (HP:0000099)1.66263239
136Bicuspid aortic valve (HP:0001647)1.66030481
137Basal cell carcinoma (HP:0002671)1.66028569
138Spondylolisthesis (HP:0003302)1.66008827
139Encephalitis (HP:0002383)1.65501634
140Cervical subluxation (HP:0003308)1.65419263
141Prominent nose (HP:0000448)1.63963884
142Abnormality of the peritoneum (HP:0002585)1.63348612
143Selective tooth agenesis (HP:0001592)1.63218134
144Aortic aneurysm (HP:0004942)1.62637611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B2.76790399
2LMTK22.51336106
3BMPR22.45023362
4MAP4K12.35666505
5TYK22.26139286
6RPS6KA42.24995430
7EIF2AK12.17845724
8SCYL22.11684033
9TBK12.11133592
10JAK32.09985133
11MAP3K142.08764746
12NEK22.05188464
13NME22.02986845
14ERN12.02094648
15MAP3K101.90377007
16FRK1.89163032
17CDC71.87803771
18KIT1.86345885
19IRAK11.82133183
20STK101.81869125
21BLK1.69175983
22WEE11.68542180
23FLT31.66125274
24ZAP701.63433232
25CDK121.61511808
26PIM21.59168080
27FES1.58773932
28CAMKK21.53535882
29IRAK41.46301482
30IKBKB1.45963601
31BUB11.44508382
32EEF2K1.43872259
33BRD41.41168971
34GRK71.39906781
35PKN21.35229337
36TXK1.32034834
37NEK91.31821124
38TRIB31.31801684
39AKT31.29577200
40PIM11.29253965
41IKBKE1.28148354
42CHUK1.27295905
43STK31.26500831
44YES11.24895190
45CDK41.24775128
46EIF2AK31.24315315
47TESK21.23384666
48BTK1.17315754
49LRRK21.15309892
50SIK31.15207957
51TGFBR21.14389091
52IRAK21.14294540
53ADRBK21.13864835
54CSF1R1.12842280
55PRKCQ1.12761371
56KDR1.12497129
57MAP3K81.12416022
58BRSK21.10445357
59FGR1.08038915
60MST41.07664577
61TEC1.07307559
62TGFBR11.07024870
63ERBB31.04747411
64PLK41.04478106
65CDK61.03356711
66STK41.03021906
67ATR0.99355323
68AURKB0.99159915
69CDK70.98963296
70TAF10.97847908
71PIK3CG0.97498921
72MAP3K130.95900826
73DYRK30.95880650
74TTK0.91794292
75PAK40.90801617
76MAP2K30.90699824
77RPS6KB20.88203356
78JAK10.87909183
79PLK10.85900609
80TNK20.83553128
81SYK0.83145891
82CLK10.82565611
83FGFR40.78323337
84RAF10.78028789
85MAPK70.77945156
86CSK0.77164966
87LYN0.76151195
88LCK0.72341626
89HCK0.69716847
90BMPR1B0.69282732
91TSSK60.68801570
92MAP3K50.67732495
93IRAK30.66407713
94RIPK40.65232460
95STK240.65150278
96MATK0.65099487
97PRPF4B0.63616721
98TRPM70.63520765
99MARK30.63424963
100FER0.62329133
101GRK60.61992615
102CHEK20.61836641
103HIPK20.60967866
104PIK3CA0.60474359
105MAP3K20.59502236
106ABL20.58386636
107ABL10.58104965
108MAP3K110.57806446
109EIF2AK20.57092596
110NUAK10.57004699
111TAOK30.56971470
112SRPK10.56771766
113PBK0.56755452
114PDGFRB0.56630831
115ITK0.56498550
116CHEK10.55144727
117EGFR0.54584524
118MAP3K30.54254198
119PASK0.54189626
120MAPK110.54066476
121FGFR30.52895202
122JAK20.52800068
123IGF1R0.49912579
124MELK0.49857587
125PTK60.48227675
126LATS10.47887628
127MAPKAPK30.46755346
128NLK0.46716320
129SGK20.46132118
130PRKG20.44847884
131MAPK130.44489477
132MKNK10.44393856
133VRK10.43888611
134CCNB10.43753918
135MAPKAPK20.43624096
136CDK90.43288720
137PRKAA20.42499199
138TIE10.40365764
139PDGFRA0.39171280
140BCR0.38660358
141PDK10.34348162
142ATM0.33437273
143TAOK20.30373729
144MKNK20.30019268
145PTK2B0.27932471

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053202.68550239
2DNA replication_Homo sapiens_hsa030302.66769394
3Type I diabetes mellitus_Homo sapiens_hsa049402.18849581
4Leishmaniasis_Homo sapiens_hsa051402.09177111
5Cell cycle_Homo sapiens_hsa041102.00093516
6Mismatch repair_Homo sapiens_hsa034301.98157770
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95971214
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93851440
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.91092139
10Legionellosis_Homo sapiens_hsa051341.88790290
11Herpes simplex infection_Homo sapiens_hsa051681.82382795
12Base excision repair_Homo sapiens_hsa034101.81681045
13Measles_Homo sapiens_hsa051621.81161461
14Antigen processing and presentation_Homo sapiens_hsa046121.75703426
15One carbon pool by folate_Homo sapiens_hsa006701.70794372
16RNA transport_Homo sapiens_hsa030131.67019199
17p53 signaling pathway_Homo sapiens_hsa041151.66127241
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64541867
19Spliceosome_Homo sapiens_hsa030401.54879403
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54756822
21Homologous recombination_Homo sapiens_hsa034401.51542084
22African trypanosomiasis_Homo sapiens_hsa051431.51337193
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47923753
24Osteoclast differentiation_Homo sapiens_hsa043801.47137092
25Primary immunodeficiency_Homo sapiens_hsa053401.46856140
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.46056009
27Staphylococcus aureus infection_Homo sapiens_hsa051501.44856966
28Influenza A_Homo sapiens_hsa051641.44040583
29B cell receptor signaling pathway_Homo sapiens_hsa046621.41000671
30Proteasome_Homo sapiens_hsa030501.40735323
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34687349
32Shigellosis_Homo sapiens_hsa051311.32972794
33Apoptosis_Homo sapiens_hsa042101.31682336
34Nucleotide excision repair_Homo sapiens_hsa034201.28434278
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25170560
36TNF signaling pathway_Homo sapiens_hsa046681.23244791
37Graft-versus-host disease_Homo sapiens_hsa053321.23166935
38Epstein-Barr virus infection_Homo sapiens_hsa051691.22143839
39Hepatitis B_Homo sapiens_hsa051611.21239773
40Chronic myeloid leukemia_Homo sapiens_hsa052201.17935920
41Toxoplasmosis_Homo sapiens_hsa051451.17850636
42Pyrimidine metabolism_Homo sapiens_hsa002401.17847394
43Malaria_Homo sapiens_hsa051441.16965459
44Allograft rejection_Homo sapiens_hsa053301.15920924
45Ribosome_Homo sapiens_hsa030101.15852378
46Small cell lung cancer_Homo sapiens_hsa052221.14745969
47Hematopoietic cell lineage_Homo sapiens_hsa046401.14672327
48RNA degradation_Homo sapiens_hsa030181.12114809
49Viral carcinogenesis_Homo sapiens_hsa052031.11608820
50RNA polymerase_Homo sapiens_hsa030201.10957725
51Pertussis_Homo sapiens_hsa051331.04854165
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04692931
53Acute myeloid leukemia_Homo sapiens_hsa052211.02854269
54Tuberculosis_Homo sapiens_hsa051521.01732492
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01242078
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01232348
57Dorso-ventral axis formation_Homo sapiens_hsa043200.99954390
58Non-homologous end-joining_Homo sapiens_hsa034500.98781410
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.98063876
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97791257
61HTLV-I infection_Homo sapiens_hsa051660.94572867
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94037477
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92667193
64Pancreatic cancer_Homo sapiens_hsa052120.92590411
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91256856
66Fanconi anemia pathway_Homo sapiens_hsa034600.89719380
67Asthma_Homo sapiens_hsa053100.88892083
68Phagosome_Homo sapiens_hsa041450.86740846
69Systemic lupus erythematosus_Homo sapiens_hsa053220.84554083
70Viral myocarditis_Homo sapiens_hsa054160.84294157
71T cell receptor signaling pathway_Homo sapiens_hsa046600.84050785
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83914136
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82775041
74Selenocompound metabolism_Homo sapiens_hsa004500.81922868
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77846264
76Caffeine metabolism_Homo sapiens_hsa002320.77724867
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77662424
78Basal transcription factors_Homo sapiens_hsa030220.77507633
79Folate biosynthesis_Homo sapiens_hsa007900.76593798
80Salmonella infection_Homo sapiens_hsa051320.75422188
81MicroRNAs in cancer_Homo sapiens_hsa052060.74447631
82Lysosome_Homo sapiens_hsa041420.71859610
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69585085
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69091834
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.68039299
86Colorectal cancer_Homo sapiens_hsa052100.67570545
87Pentose phosphate pathway_Homo sapiens_hsa000300.67564142
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66205060
89Hepatitis C_Homo sapiens_hsa051600.65115990
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63705734
91mRNA surveillance pathway_Homo sapiens_hsa030150.62313924
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60679214
93Chemokine signaling pathway_Homo sapiens_hsa040620.60676097
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.59349941
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58962362
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.58604275
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56773069
98Thyroid cancer_Homo sapiens_hsa052160.56269968
99Other glycan degradation_Homo sapiens_hsa005110.56186517
100Prolactin signaling pathway_Homo sapiens_hsa049170.55927034
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54777673
102Notch signaling pathway_Homo sapiens_hsa043300.54428794
103HIF-1 signaling pathway_Homo sapiens_hsa040660.52275493
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51956190
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50826047
106Non-small cell lung cancer_Homo sapiens_hsa052230.50687662
107mTOR signaling pathway_Homo sapiens_hsa041500.49788500
108Vitamin B6 metabolism_Homo sapiens_hsa007500.49399432
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48750319
110Platelet activation_Homo sapiens_hsa046110.48221178
111FoxO signaling pathway_Homo sapiens_hsa040680.47913629
112Complement and coagulation cascades_Homo sapiens_hsa046100.47709275
113Sphingolipid metabolism_Homo sapiens_hsa006000.46980503
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.46149540
115Rheumatoid arthritis_Homo sapiens_hsa053230.43277258
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.42011010
117Inositol phosphate metabolism_Homo sapiens_hsa005620.41472574
118ABC transporters_Homo sapiens_hsa020100.39623927
119Regulation of autophagy_Homo sapiens_hsa041400.35643272
120Circadian rhythm_Homo sapiens_hsa047100.34849007
121Renal cell carcinoma_Homo sapiens_hsa052110.34136580
122Insulin resistance_Homo sapiens_hsa049310.29316847
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.28892100
124Amoebiasis_Homo sapiens_hsa051460.28551573
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.24521444
126Prostate cancer_Homo sapiens_hsa052150.22835147
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.21811136
128Type II diabetes mellitus_Homo sapiens_hsa049300.19955541
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16351809
130Renin-angiotensin system_Homo sapiens_hsa046140.16054824
131Propanoate metabolism_Homo sapiens_hsa006400.15886944

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