PAPD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1attachment of spindle microtubules to kinetochore (GO:0008608)5.57370393
2monoubiquitinated protein deubiquitination (GO:0035520)5.56615172
3fibroblast migration (GO:0010761)5.38332648
4negative regulation of translation, ncRNA-mediated (GO:0040033)4.82365352
5regulation of translation, ncRNA-mediated (GO:0045974)4.82365352
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.82365352
7regulation of RNA export from nucleus (GO:0046831)4.62852040
8serine family amino acid catabolic process (GO:0009071)4.57494302
9nuclear pore complex assembly (GO:0051292)4.52724927
10pre-miRNA processing (GO:0031054)4.51074580
11mitotic sister chromatid cohesion (GO:0007064)4.26872565
12nuclear pore organization (GO:0006999)4.15915049
13glycine metabolic process (GO:0006544)4.11288243
14regulation of nucleobase-containing compound transport (GO:0032239)4.01612587
15cullin deneddylation (GO:0010388)4.00152445
16rRNA methylation (GO:0031167)3.98259443
17protein K11-linked deubiquitination (GO:0035871)3.86661745
18regulation of DNA endoreduplication (GO:0032875)3.81150798
19kinetochore assembly (GO:0051382)3.80445892
20transcytosis (GO:0045056)3.72761149
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.71681827
22regulation of meiosis I (GO:0060631)3.70155625
23kinetochore organization (GO:0051383)3.68136287
24RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.66947947
25regulation of translational fidelity (GO:0006450)3.62512738
26microtubule anchoring (GO:0034453)3.62429009
27cysteine metabolic process (GO:0006534)3.62293053
28protein deneddylation (GO:0000338)3.49510843
29serine family amino acid metabolic process (GO:0009069)3.48985293
30rRNA modification (GO:0000154)3.47004443
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.43154284
32regulation of mitotic spindle checkpoint (GO:1903504)3.43154284
33DNA double-strand break processing (GO:0000729)3.41008412
34folic acid metabolic process (GO:0046655)3.38122161
35pantothenate metabolic process (GO:0015939)3.34335667
36cytoplasmic mRNA processing body assembly (GO:0033962)3.32713911
37magnesium ion transport (GO:0015693)3.27276638
38Leydig cell differentiation (GO:0033327)3.26803618
39somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.26496014
40isotype switching (GO:0045190)3.26496014
41somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.26496014
42proteasome assembly (GO:0043248)3.26238467
43chromatin remodeling at centromere (GO:0031055)3.24311183
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24267499
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24267499
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.24267499
47urea metabolic process (GO:0019627)3.21560967
48urea cycle (GO:0000050)3.21560967
49CENP-A containing nucleosome assembly (GO:0034080)3.19261416
50kynurenine metabolic process (GO:0070189)3.18349574
51regulation of cilium movement (GO:0003352)3.17193603
52positive regulation of chromosome segregation (GO:0051984)3.16850751
53neural tube formation (GO:0001841)3.16512388
54regulation of translational elongation (GO:0006448)3.15151858
55nucleobase biosynthetic process (GO:0046112)3.14673765
56mitotic metaphase plate congression (GO:0007080)3.13849050
57acrosome assembly (GO:0001675)3.13515635
58establishment of protein localization to Golgi (GO:0072600)3.10689811
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09381984
60tryptophan catabolic process (GO:0006569)3.08273539
61indole-containing compound catabolic process (GO:0042436)3.08273539
62indolalkylamine catabolic process (GO:0046218)3.08273539
63centriole replication (GO:0007099)3.04878664
64negative regulation of fatty acid biosynthetic process (GO:0045717)3.04284931
65serine family amino acid biosynthetic process (GO:0009070)3.04255194
66G1 DNA damage checkpoint (GO:0044783)3.03838249
67microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.03444033
68pore complex assembly (GO:0046931)3.00316759
69aromatic amino acid family catabolic process (GO:0009074)3.00301439
70histone exchange (GO:0043486)2.98884772
71protein targeting to Golgi (GO:0000042)2.98399268
72intestinal epithelial cell development (GO:0060576)2.98156917
73* histone mRNA metabolic process (GO:0008334)2.95325970
74gene silencing by RNA (GO:0031047)2.92240292
75establishment of chromosome localization (GO:0051303)2.91905738
76synapsis (GO:0007129)2.91839917
77DNA catabolic process, exonucleolytic (GO:0000738)2.91696217
78spindle checkpoint (GO:0031577)2.90160882
79organelle disassembly (GO:1903008)2.89163687
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.88195389
81termination of RNA polymerase III transcription (GO:0006386)2.88195389
82mitotic nuclear envelope disassembly (GO:0007077)2.85137824
83activation of Rac GTPase activity (GO:0032863)2.84919079
84regulation of transcription from RNA polymerase I promoter (GO:0006356)2.84782812
85embryonic placenta development (GO:0001892)2.84325613
86meiotic cell cycle (GO:0051321)2.82414739
87regulation of centriole replication (GO:0046599)2.81941378
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81012630
89peptidyl-lysine dimethylation (GO:0018027)2.80483051
90positive regulation of histone H3-K4 methylation (GO:0051571)2.80055463
91mitotic spindle checkpoint (GO:0071174)2.79064756
92regulation of bile acid biosynthetic process (GO:0070857)2.77156288
93maturation of 5.8S rRNA (GO:0000460)2.77110772
94positive regulation of histone methylation (GO:0031062)2.76304205
95dicarboxylic acid biosynthetic process (GO:0043650)2.75829043
96transcription elongation from RNA polymerase I promoter (GO:0006362)2.75684226
97ribosome assembly (GO:0042255)2.75390501
98tryptophan metabolic process (GO:0006568)2.75209369
99positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.74655064
100regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.74655064
101somite rostral/caudal axis specification (GO:0032525)2.74616877
102regulation of histone H3-K9 methylation (GO:0051570)2.74515923
103histone lysine methylation (GO:0034968)2.74336501
104termination of RNA polymerase I transcription (GO:0006363)2.74123074
105regulation of nuclear cell cycle DNA replication (GO:0033262)2.74006899
106histone H2A monoubiquitination (GO:0035518)2.73791067
107mitotic G1 DNA damage checkpoint (GO:0031571)2.72256910
108DNA-dependent DNA replication (GO:0006261)2.71552403
109nonmotile primary cilium assembly (GO:0035058)2.71498618
110protein prenylation (GO:0018342)2.71206676
111prenylation (GO:0097354)2.71206676
112protein neddylation (GO:0045116)2.70757130
113purine nucleobase biosynthetic process (GO:0009113)2.70123515
114erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.69644968
115L-phenylalanine catabolic process (GO:0006559)2.69644968
116peptidyl-lysine trimethylation (GO:0018023)2.69092155
117nuclear envelope disassembly (GO:0051081)2.68840776
118membrane disassembly (GO:0030397)2.68840776
119histone H3-K9 methylation (GO:0051567)2.67586723
120response to xenobiotic stimulus (GO:0009410)2.67495401
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67081109
122somatic recombination of immunoglobulin gene segments (GO:0016447)2.66737256
123negative regulation of fibrinolysis (GO:0051918)2.66521201
124embryonic body morphogenesis (GO:0010172)2.65901899
125transcription from mitochondrial promoter (GO:0006390)2.65718178
126nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.65551494
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.65012583
128regulation of mitotic metaphase/anaphase transition (GO:0030071)2.64790355
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64790355
130positive regulation of DNA-templated transcription, initiation (GO:2000144)2.64202783
131pseudouridine synthesis (GO:0001522)2.64098081
132folic acid transport (GO:0015884)2.63087789
133DNA replication checkpoint (GO:0000076)2.60831402
134nitrogen cycle metabolic process (GO:0071941)2.60587304
135DNA deamination (GO:0045006)2.59807042
136positive regulation of protein import into nucleus, translocation (GO:0033160)2.59388147
137regulation of spindle organization (GO:0090224)2.57422331
138negative regulation of histone modification (GO:0031057)2.56916030
139positive regulation of mRNA 3-end processing (GO:0031442)2.56848430
140sulfur amino acid catabolic process (GO:0000098)2.56794443
141adaptation of signaling pathway (GO:0023058)2.56648490
142L-serine metabolic process (GO:0006563)2.56439199
143histone H2A acetylation (GO:0043968)2.56385067
144nucleotide-excision repair, DNA gap filling (GO:0006297)2.56162403
145single strand break repair (GO:0000012)2.55018847
146otic vesicle formation (GO:0030916)2.54033705
147regulation of fibroblast apoptotic process (GO:2000269)2.53319326
148regulation of sister chromatid cohesion (GO:0007063)2.52787683
149NLS-bearing protein import into nucleus (GO:0006607)2.52701120
150establishment of protein localization to mitochondrial membrane (GO:0090151)2.52658082
151mitotic G2/M transition checkpoint (GO:0044818)2.52579627
152negative regulation of histone methylation (GO:0031061)2.52443399
153regulation of sister chromatid segregation (GO:0033045)2.52014760
154regulation of mitotic sister chromatid separation (GO:0010965)2.52014760
155regulation of mitotic sister chromatid segregation (GO:0033047)2.52014760
156mismatch repair (GO:0006298)2.51600089
157transcription initiation from RNA polymerase I promoter (GO:0006361)2.51046156
158ribonucleoprotein complex disassembly (GO:0032988)2.51000080
159histone methylation (GO:0016571)2.50854424
160protein localization to kinetochore (GO:0034501)2.50576774
161sister chromatid cohesion (GO:0007062)2.49879799
162piRNA metabolic process (GO:0034587)2.49337895
163nucleotide-excision repair, DNA damage removal (GO:0000718)2.48727588
164DNA excision (GO:0044349)2.48727588
165metaphase plate congression (GO:0051310)2.44745401
166regulation of transforming growth factor beta2 production (GO:0032909)2.43874838
167embryonic process involved in female pregnancy (GO:0060136)2.43693678
168regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.43073453
169erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.42756431
170L-phenylalanine metabolic process (GO:0006558)2.42756431
171negative regulation of cholesterol transport (GO:0032375)2.42090268
172negative regulation of sterol transport (GO:0032372)2.42090268
173vitamin transmembrane transport (GO:0035461)2.41038776
174regulation of fibrinolysis (GO:0051917)2.40295380
175alpha-linolenic acid metabolic process (GO:0036109)2.39704759
176regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.39442866
177estrogen metabolic process (GO:0008210)2.39139022
178histone H3-K9 demethylation (GO:0033169)2.37534977
179synaptonemal complex assembly (GO:0007130)2.36972806
180negative regulation of thymocyte apoptotic process (GO:0070244)2.36901898
181mitotic G1/S transition checkpoint (GO:0044819)2.36869523
182histone H3-K9 modification (GO:0061647)2.36599783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.94598203
2SALL1_21062744_ChIP-ChIP_HESCs_Human5.41099022
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.10705576
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.76265254
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.56368889
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20498251
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.08616687
8* RXR_22158963_ChIP-Seq_LIVER_Mouse2.96239376
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69860387
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64140571
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64031447
12VDR_22108803_ChIP-Seq_LS180_Human2.58271905
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.49285401
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.42764088
15ELK1_19687146_ChIP-ChIP_HELA_Human2.41312352
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36936376
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34550683
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30606773
19AR_21909140_ChIP-Seq_LNCAP_Human2.30445859
20FUS_26573619_Chip-Seq_HEK293_Human2.28550030
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.27751061
22* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.23661905
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.16332379
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14623296
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.11576571
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07983387
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.07831075
28PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06377330
29* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.02867982
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.97538259
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.97538259
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.97538259
33P300_19829295_ChIP-Seq_ESCs_Human1.92306279
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90276794
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.89410040
36MYC_22102868_ChIP-Seq_BL_Human1.87310437
37PKCTHETA_26484144_Chip-Seq_BREAST_Human1.84257855
38* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84068287
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.78462653
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.78239700
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75648570
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.75255831
43GBX2_23144817_ChIP-Seq_PC3_Human1.74218480
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.69373904
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66213812
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65530124
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64103997
48NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.62735924
49TAF15_26573619_Chip-Seq_HEK293_Human1.60943656
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58387659
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58079426
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57181982
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.56785196
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55477513
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55088845
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54961661
57VDR_23849224_ChIP-Seq_CD4+_Human1.54458648
58* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53845931
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.53094440
60ER_23166858_ChIP-Seq_MCF-7_Human1.52036851
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51749300
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51293966
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.51145387
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51111905
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51027278
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50103713
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.49329016
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48845235
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48061634
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45682194
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45591932
72ZNF263_19887448_ChIP-Seq_K562_Human1.44847146
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.44126583
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44119771
75SMAD4_21799915_ChIP-Seq_A2780_Human1.43237944
76CBP_20019798_ChIP-Seq_JUKART_Human1.43113327
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43113327
78IGF1R_20145208_ChIP-Seq_DFB_Human1.40198469
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38688404
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38205953
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38205953
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37217190
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33586267
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.33585051
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30376984
86* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30287016
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30261569
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29797707
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29460420
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.28904986
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28829786
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28415974
93P53_22387025_ChIP-Seq_ESCs_Mouse1.28116381
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28012401
95* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27891533
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.27338294
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27247972
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26195254
99P300_18555785_Chip-Seq_ESCs_Mouse1.25945960
100STAT3_23295773_ChIP-Seq_U87_Human1.25643409
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24798271
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24663959
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23390324
104TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21678989
105* KDM2B_26808549_Chip-Seq_DND41_Human1.21567327
106CDX2_22108803_ChIP-Seq_LS180_Human1.21206503
107STAT3_18555785_Chip-Seq_ESCs_Mouse1.20289487
108BCAT_22108803_ChIP-Seq_LS180_Human1.20254986
109MYC_18940864_ChIP-ChIP_HL60_Human1.19007464
110WDR5_24793694_ChIP-Seq_LNCAP_Human1.17652453
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.17061136
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16858202
113ZNF274_21170338_ChIP-Seq_K562_Hela1.15427003
114TCF4_22108803_ChIP-Seq_LS180_Human1.15366290
115OCT4_18555785_Chip-Seq_ESCs_Mouse1.15099146
116EWS_26573619_Chip-Seq_HEK293_Human1.14076114
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13973599
118TCF4_23295773_ChIP-Seq_U87_Human1.12760106
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.11836082
120* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11453681
121TCF7_22412390_ChIP-Seq_EML_Mouse1.11107524
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.10138231
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09968663
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.08305512
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07964573
126MYC_18555785_ChIP-Seq_MESCs_Mouse1.07343250
127RUNX2_22187159_ChIP-Seq_PCA_Human1.06994528
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.06650912
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06617325
130AR_25329375_ChIP-Seq_VCAP_Human1.05777108
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05496921
132FOXP3_21729870_ChIP-Seq_TREG_Human1.05420996
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05232019
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05172763
135KDM5A_27292631_Chip-Seq_BREAST_Human1.05167587
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04691690
137CHD1_26751641_Chip-Seq_LNCaP_Human1.03962095
138PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02450843
139* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02082898
140OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01857861
141CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00976709
142FLI1_21867929_ChIP-Seq_TH2_Mouse1.00609057
143* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00326561
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00281950
145STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99993217
146GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99884436
147MYB_26560356_Chip-Seq_TH1_Human0.99835836
148SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99773573
149MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99300246
150NANOG_19829295_ChIP-Seq_ESCs_Human0.98681197
151PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98570198
152KDM2B_26808549_Chip-Seq_JURKAT_Human0.98464637
153TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97898667
154FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96177004
155CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95873794
156RXR_22108803_ChIP-Seq_LS180_Human0.95007356
157TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92874696
158PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90649856
159* FOXA2_19822575_ChIP-Seq_HepG2_Human0.90465316
160CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89972604
161NANOG_16518401_ChIP-PET_MESCs_Mouse0.89846910
162NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88990295
163UTX_26944678_Chip-Seq_JUKART_Human0.88732413
164KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88281066
165TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87708612
166GATA6_25053715_ChIP-Seq_YYC3_Human0.86058475
167SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83229898
168SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81503016
169* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80777627
170PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80086754
171STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79108206
172TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78594419
173MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78035467
174MYC_19030024_ChIP-ChIP_MESCs_Mouse0.77762222
175FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77563301
176BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77318884
177FOXA1_25552417_ChIP-Seq_VCAP_Human0.76775304
178* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.76570350
179UBF1/2_26484160_Chip-Seq_HMECs_Human0.75747121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.00663991
2MP0005360_urolithiasis4.13797075
3MP0003941_abnormal_skin_development4.08152193
4MP0002139_abnormal_hepatobiliary_system4.04575251
5MP0000569_abnormal_digit_pigmentation3.83847927
6MP0005085_abnormal_gallbladder_physiolo3.36781581
7MP0005365_abnormal_bile_salt3.18759538
8MP0003950_abnormal_plasma_membrane2.92332406
9MP0008007_abnormal_cellular_replicative2.72377773
10MP0003111_abnormal_nucleus_morphology2.49225239
11MP0001188_hyperpigmentation2.47300046
12MP0003787_abnormal_imprinting2.46807860
13MP0004957_abnormal_blastocyst_morpholog2.35049083
14MP0003705_abnormal_hypodermis_morpholog2.26602210
15MP0010094_abnormal_chromosome_stability2.26229130
16MP0003693_abnormal_embryo_hatching2.25566315
17MP0003077_abnormal_cell_cycle2.25116098
18MP0008875_abnormal_xenobiotic_pharmacok2.16242641
19MP0002102_abnormal_ear_morphology2.07276343
20MP0008877_abnormal_DNA_methylation2.06523566
21MP0003890_abnormal_embryonic-extraembry2.03616293
22MP0005380_embryogenesis_phenotype1.97977411
23MP0001672_abnormal_embryogenesis/_devel1.97977411
24MP0003195_calcinosis1.86368188
25MP0000427_abnormal_hair_cycle1.86117094
26MP0004185_abnormal_adipocyte_glucose1.81904339
27MP0003252_abnormal_bile_duct1.79448315
28MP0003123_paternal_imprinting1.78891351
29MP0001730_embryonic_growth_arrest1.74796294
30MP0000350_abnormal_cell_proliferation1.70492695
31MP0004197_abnormal_fetal_growth/weight/1.69133958
32MP0002086_abnormal_extraembryonic_tissu1.67181388
33MP0003984_embryonic_growth_retardation1.65652337
34MP0003121_genomic_imprinting1.64515326
35MP0002088_abnormal_embryonic_growth/wei1.64242244
36MP0010329_abnormal_lipoprotein_level1.62478299
37MP0002084_abnormal_developmental_patter1.62104903
38MP0009697_abnormal_copulation1.60145314
39MP0005647_abnormal_sex_gland1.59680276
40MP0001697_abnormal_embryo_size1.51780050
41MP0008995_early_reproductive_senescence1.48457408
42MP0002166_altered_tumor_susceptibility1.47665479
43MP0006072_abnormal_retinal_apoptosis1.46600863
44MP0005076_abnormal_cell_differentiation1.46242524
45MP0002138_abnormal_hepatobiliary_system1.43571167
46MP0010307_abnormal_tumor_latency1.43554411
47MP0003115_abnormal_respiratory_system1.42443125
48MP0009840_abnormal_foam_cell1.42112682
49MP0010352_gastrointestinal_tract_polyps1.39902577
50MP0003786_premature_aging1.38581657
51MP0002006_tumorigenesis1.37188980
52MP0009278_abnormal_bone_marrow1.36297342
53MP0001661_extended_life_span1.35802168
54MP0005367_renal/urinary_system_phenotyp1.33549461
55MP0000516_abnormal_urinary_system1.33549461
56MP0008058_abnormal_DNA_repair1.32325828
57MP0005174_abnormal_tail_pigmentation1.31443583
58MP0005257_abnormal_intraocular_pressure1.29044967
59MP0002160_abnormal_reproductive_system1.28171078
60MP0001501_abnormal_sleep_pattern1.27311756
61MP0005084_abnormal_gallbladder_morpholo1.27301055
62MP0001929_abnormal_gametogenesis1.26318020
63MP0004808_abnormal_hematopoietic_stem1.21026272
64MP0000372_irregular_coat_pigmentation1.20862930
65MP0002085_abnormal_embryonic_tissue1.20517968
66MP0005551_abnormal_eye_electrophysiolog1.18896459
67MP0002277_abnormal_respiratory_mucosa1.14936152
68MP0000609_abnormal_liver_physiology1.14744846
69MP0010678_abnormal_skin_adnexa1.14636083
70MP0003303_peritoneal_inflammation1.13002853
71MP0005310_abnormal_salivary_gland1.11972977
72MP0009046_muscle_twitch1.11323519
73MP0003937_abnormal_limbs/digits/tail_de1.10848235
74MP0005332_abnormal_amino_acid1.10497395
75MP0008789_abnormal_olfactory_epithelium1.10396119
76MP0003221_abnormal_cardiomyocyte_apopto1.09349457
77MP0003119_abnormal_digestive_system1.09247912
78MP0005645_abnormal_hypothalamus_physiol1.07218859
79MP0002210_abnormal_sex_determination1.06689280
80MP0006035_abnormal_mitochondrial_morpho1.06022956
81MP0001324_abnormal_eye_pigmentation1.05638081
82MP0005451_abnormal_body_composition1.03934426
83MP0003718_maternal_effect1.03168269
84MP0003091_abnormal_cell_migration1.02300233
85MP0000733_abnormal_muscle_development1.01831756
86MP0000767_abnormal_smooth_muscle1.00224806
87MP0002080_prenatal_lethality0.99661173
88MP0009703_decreased_birth_body0.98184028
89MP0005397_hematopoietic_system_phenotyp0.94575407
90MP0001545_abnormal_hematopoietic_system0.94575407
91MP0002396_abnormal_hematopoietic_system0.94488780
92MP0002163_abnormal_gland_morphology0.94442785
93MP0003698_abnormal_male_reproductive0.94157033
94MP0009672_abnormal_birth_weight0.94089217
95MP0008932_abnormal_embryonic_tissue0.93457411
96MP0001145_abnormal_male_reproductive0.92627530
97MP0000631_abnormal_neuroendocrine_gland0.92344267
98MP0005410_abnormal_fertilization0.91137398
99MP0003943_abnormal_hepatobiliary_system0.90953147
100MP0005389_reproductive_system_phenotype0.90508390
101MP0005395_other_phenotype0.90162892
102MP0005083_abnormal_biliary_tract0.87878223
103MP0003699_abnormal_female_reproductive0.86020388
104MP0002092_abnormal_eye_morphology0.86012654
105MP0003385_abnormal_body_wall0.85618214
106MP0000383_abnormal_hair_follicle0.85109036
107MP0000703_abnormal_thymus_morphology0.84356957
108MP0003567_abnormal_fetal_cardiomyocyte0.84298112
109MP0001340_abnormal_eyelid_morphology0.84293637
110MP0005379_endocrine/exocrine_gland_phen0.84284465
111MP0002693_abnormal_pancreas_physiology0.83357710
112MP0004019_abnormal_vitamin_homeostasis0.82985933
113MP0002161_abnormal_fertility/fecundity0.82648654
114MP0002909_abnormal_adrenal_gland0.81673108
115MP0000428_abnormal_craniofacial_morphol0.81651699
116MP0003938_abnormal_ear_development0.80951592
117MP0001853_heart_inflammation0.80577100
118MP0000653_abnormal_sex_gland0.80197996
119MP0005075_abnormal_melanosome_morpholog0.80147596
120MP0001529_abnormal_vocalization0.80078933
121MP0002233_abnormal_nose_morphology0.79859579
122MP0001286_abnormal_eye_development0.78091280
123MP0000598_abnormal_liver_morphology0.77785228
124MP0002009_preneoplasia0.77423386
125MP0002697_abnormal_eye_size0.77321934
126MP0002272_abnormal_nervous_system0.76661596
127MP0001984_abnormal_olfaction0.76607634
128MP0005646_abnormal_pituitary_gland0.76094679
129MP0003191_abnormal_cellular_cholesterol0.75455900
130MP0003828_pulmonary_edema0.75404395
131MP0005248_abnormal_Harderian_gland0.75398846
132MP0004130_abnormal_muscle_cell0.75169066
133MP0002751_abnormal_autonomic_nervous0.74898409
134MP0005253_abnormal_eye_physiology0.74776831
135MP0001666_abnormal_nutrient_absorption0.74699467
136MP0009333_abnormal_splenocyte_physiolog0.74548029
137MP0005666_abnormal_adipose_tissue0.74114894
138MP0005621_abnormal_cell_physiology0.73242656
139MP0004742_abnormal_vestibular_system0.72960094
140MP0001293_anophthalmia0.72568448
141MP0004142_abnormal_muscle_tone0.72474094
142MP0001119_abnormal_female_reproductive0.70292082
143MP0002019_abnormal_tumor_incidence0.70260476
144MP0002938_white_spotting0.69106591
145MP0003936_abnormal_reproductive_system0.68869271
146MP0009053_abnormal_anal_canal0.67779518
147MP0001986_abnormal_taste_sensitivity0.67480379
148MP0000685_abnormal_immune_system0.66965689
149MP0005423_abnormal_somatic_nervous0.66783743
150MP0000015_abnormal_ear_pigmentation0.61496742
151MP0001485_abnormal_pinna_reflex0.61375427
152MP0002928_abnormal_bile_duct0.57399154

Predicted human phenotypes

RankGene SetZ-score
1Myocardial infarction (HP:0001658)5.21958007
2Axonal loss (HP:0003447)4.77105016
3Acute myeloid leukemia (HP:0004808)4.37575952
4Conjunctival telangiectasia (HP:0000524)4.32541443
5Bundle branch block (HP:0011710)3.76020110
6Impulsivity (HP:0100710)3.44862597
7Hyperglycinemia (HP:0002154)3.32906741
8Abnormality of the vasculature of the conjunctiva (HP:0008054)3.27137763
9Facial hemangioma (HP:0000329)3.23469426
10Pancreatic cysts (HP:0001737)3.23084451
11Deep venous thrombosis (HP:0002625)3.17852014
12Squamous cell carcinoma (HP:0002860)3.15567727
13Renal cortical cysts (HP:0000803)3.11610480
14Hypobetalipoproteinemia (HP:0003563)3.10017721
15Birth length less than 3rd percentile (HP:0003561)3.00897113
16Anterior segment dysgenesis (HP:0007700)2.99626147
17Progressive external ophthalmoplegia (HP:0000590)2.95408788
18Abnormality of purine metabolism (HP:0004352)2.90762032
19Partial agenesis of the corpus callosum (HP:0001338)2.88189376
20Hypochromic microcytic anemia (HP:0004840)2.86386879
21Hypothermia (HP:0002045)2.81413072
22Oligodactyly (hands) (HP:0001180)2.79439624
23Hyperglycinuria (HP:0003108)2.79416809
24Abnormality of the lower motor neuron (HP:0002366)2.74352471
25Bifid tongue (HP:0010297)2.74220702
26Cortical dysplasia (HP:0002539)2.72964522
27Pancreatic fibrosis (HP:0100732)2.71030765
28Molar tooth sign on MRI (HP:0002419)2.70676305
29Abnormality of midbrain morphology (HP:0002418)2.70676305
30Neoplasm of the small intestine (HP:0100833)2.68003436
31Male infertility (HP:0003251)2.67547066
32Progressive inability to walk (HP:0002505)2.67534723
33Delayed puberty (HP:0000823)2.67119029
34Upper motor neuron abnormality (HP:0002127)2.55021607
35Abnormality of chromosome stability (HP:0003220)2.52891024
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51261932
37Stomach cancer (HP:0012126)2.49558083
38Abnormality of nucleobase metabolism (HP:0010932)2.45958265
39Methylmalonic acidemia (HP:0002912)2.45239652
40True hermaphroditism (HP:0010459)2.43250391
41Stomatitis (HP:0010280)2.43128999
42Medial flaring of the eyebrow (HP:0010747)2.42069937
43Volvulus (HP:0002580)2.40846130
44Gaze-evoked nystagmus (HP:0000640)2.37895310
45Epidermoid cyst (HP:0200040)2.37689089
46Abnormality of the labia minora (HP:0012880)2.36931631
47Skull defect (HP:0001362)2.36308989
48Intrahepatic cholestasis (HP:0001406)2.35965942
49Fair hair (HP:0002286)2.34470032
50Abnormality of the renal cortex (HP:0011035)2.34469584
51Neoplasm of the rectum (HP:0100743)2.33164855
52Broad-based gait (HP:0002136)2.32968785
53Disinhibition (HP:0000734)2.32922916
54Peripheral demyelination (HP:0011096)2.31009431
55Pustule (HP:0200039)2.30318048
56Nephronophthisis (HP:0000090)2.28388992
57Neoplasm of the adrenal cortex (HP:0100641)2.24684969
58Abnormality of serine family amino acid metabolism (HP:0010894)2.24600309
59Abnormality of glycine metabolism (HP:0010895)2.24600309
60Limb dystonia (HP:0002451)2.24412140
61Xanthomatosis (HP:0000991)2.24200772
62Complete atrioventricular canal defect (HP:0001674)2.23972511
63Amyotrophic lateral sclerosis (HP:0007354)2.22098364
64Type II lissencephaly (HP:0007260)2.20214231
65Thyroid carcinoma (HP:0002890)2.18479139
66Chromsome breakage (HP:0040012)2.18000130
67Papillary thyroid carcinoma (HP:0002895)2.17516312
68Hypolipoproteinemia (HP:0010981)2.17342436
69Colon cancer (HP:0003003)2.17081455
70Abnormality of the pons (HP:0007361)2.16530954
71Increased hepatocellular lipid droplets (HP:0006565)2.14266462
72Aplasia/Hypoplasia of the tongue (HP:0010295)2.12303404
73Abnormality of sulfur amino acid metabolism (HP:0004339)2.11540200
74Abnormality of the renal medulla (HP:0100957)2.08616028
75Abnormal rod and cone electroretinograms (HP:0008323)2.08488460
76Acute lymphatic leukemia (HP:0006721)2.07361553
77Inability to walk (HP:0002540)2.06057655
78Capillary hemangiomas (HP:0005306)2.03949165
79Pseudobulbar signs (HP:0002200)2.02274665
80Dysautonomia (HP:0002459)2.01607718
81Oligodactyly (HP:0012165)2.01035116
82Polycythemia (HP:0001901)2.00393657
83Meckel diverticulum (HP:0002245)1.99506490
84Febrile seizures (HP:0002373)1.99198692
85Sensory axonal neuropathy (HP:0003390)1.97559984
86Apathy (HP:0000741)1.96948373
87Prolonged partial thromboplastin time (HP:0003645)1.94180132
88Microtia (HP:0008551)1.93856461
89Genital tract atresia (HP:0001827)1.92419636
90Hyperlipoproteinemia (HP:0010980)1.91129530
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90631700
92Spastic diplegia (HP:0001264)1.90151158
93Spontaneous abortion (HP:0005268)1.89940180
94Neoplasm of head and neck (HP:0012288)1.89677348
95Esophageal neoplasm (HP:0100751)1.89677348
96Abnormality of lateral ventricle (HP:0030047)1.89473332
97Cutis marmorata (HP:0000965)1.88965759
98Fibroma (HP:0010614)1.88287049
99Congenital primary aphakia (HP:0007707)1.87856489
100Nausea (HP:0002018)1.87628490
101Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87504045
102Anorexia (HP:0002039)1.87075832
103Progressive macrocephaly (HP:0004481)1.87063817
104Heterotopia (HP:0002282)1.85882662
105Biliary tract neoplasm (HP:0100574)1.85580531
106Abnormality of the ileum (HP:0001549)1.85578969
107Fibrous tissue neoplasm (HP:0012316)1.85504482
108Aplasia/Hypoplasia of the uvula (HP:0010293)1.85414399
109Nephrogenic diabetes insipidus (HP:0009806)1.84731489
110Gait imbalance (HP:0002141)1.84439901
111Eosinophilia (HP:0001880)1.84291660
112Complement deficiency (HP:0004431)1.83985315
113Abnormality of serum amino acid levels (HP:0003112)1.82789250
114Abnormality of the preputium (HP:0100587)1.82765562
115Global brain atrophy (HP:0002283)1.82388893
116Embryonal renal neoplasm (HP:0011794)1.82367542
117Lipid accumulation in hepatocytes (HP:0006561)1.82366030
118Abnormality of methionine metabolism (HP:0010901)1.82291486
119Abnormality of vitamin B metabolism (HP:0004340)1.82094239
120Gastrointestinal stroma tumor (HP:0100723)1.81390783
121Abnormality of the fingertips (HP:0001211)1.80140524
122Hypoplasia of the pons (HP:0012110)1.80137653
123Abnormal lung lobation (HP:0002101)1.78559759
124Clubbing of toes (HP:0100760)1.77896968
125Posterior subcapsular cataract (HP:0007787)1.77655278
126Vaginal atresia (HP:0000148)1.76534678
127Abnormality of the vitamin B12 metabolism (HP:0004341)1.76500459
128Nephroblastoma (Wilms tumor) (HP:0002667)1.76255602
129Hypoalphalipoproteinemia (HP:0003233)1.75812519
130Azoospermia (HP:0000027)1.75540742
131Gonadotropin excess (HP:0000837)1.74449696
132Spastic tetraparesis (HP:0001285)1.74123180
133Methylmalonic aciduria (HP:0012120)1.73962478
134Breast hypoplasia (HP:0003187)1.73888663
135Esophageal varix (HP:0002040)1.73284041
136Entropion (HP:0000621)1.72964857
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72964372
138Heart block (HP:0012722)1.72611228
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.72238485
140Chronic hepatic failure (HP:0100626)1.71988230
141Abnormality of eosinophils (HP:0001879)1.71753604
142Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71124775
143Cupped ear (HP:0000378)1.70986206
144Lip pit (HP:0100267)1.70865195
145Abnormal spermatogenesis (HP:0008669)1.70486494
146T lymphocytopenia (HP:0005403)1.70253720
147Hyperventilation (HP:0002883)1.70072185
148Recurrent gram-negative bacterial infections (HP:0005420)1.69460274
149Natal tooth (HP:0000695)1.69139904
150Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68842995
151Retinal dysplasia (HP:0007973)1.68696190
152Tetraplegia (HP:0002445)1.68484405
153Congenital, generalized hypertrichosis (HP:0004540)1.68379022
154Hyperinsulinemic hypoglycemia (HP:0000825)1.68336463
155Sloping forehead (HP:0000340)1.68161906
156Abnormality of the common coagulation pathway (HP:0010990)1.67648204
157Abnormal hair whorl (HP:0010721)1.67506818
158Recurrent viral infections (HP:0004429)1.66845766
159Abnormal biliary tract morphology (HP:0012440)1.66724718
160Mutism (HP:0002300)1.66608335
161Persistence of primary teeth (HP:0006335)1.66132191
162Diminished motivation (HP:0000745)1.65974710
163Microglossia (HP:0000171)1.65753523
164Generalized hypopigmentation of hair (HP:0011358)1.65691527
165Acute necrotizing encephalopathy (HP:0006965)1.65255204
166Abnormality of T cell number (HP:0011839)1.64756847
167Short 4th metacarpal (HP:0010044)1.64635625
168Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64635625
169Infertility (HP:0000789)1.64084729
170Dyskinesia (HP:0100660)1.63070717
171Poor coordination (HP:0002370)1.62987718
172Low anterior hairline (HP:0000294)1.62943184
173Abnormal respiratory motile cilium morphology (HP:0005938)1.62928568
174Abnormal respiratory epithelium morphology (HP:0012253)1.62928568
175Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.61846944
176Absent/shortened dynein arms (HP:0200106)1.60141326
177Dynein arm defect of respiratory motile cilia (HP:0012255)1.60141326
178Highly arched eyebrow (HP:0002553)1.59763695
179Depressed nasal tip (HP:0000437)1.59254010
180Degeneration of the lateral corticospinal tracts (HP:0002314)1.57915614
181Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.57915614
182Small intestinal stenosis (HP:0012848)1.56512415
183Duodenal stenosis (HP:0100867)1.56512415
184Cortical visual impairment (HP:0100704)1.56438786
185Anencephaly (HP:0002323)1.55794955
186Increased number of teeth (HP:0011069)1.54770289
187Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.54753576
188Small hand (HP:0200055)1.54682360
189Curly hair (HP:0002212)1.54027311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK15.50648217
2PDGFRA4.20110838
3TNIK3.20408465
4MAP3K123.04833183
5CDK123.01561915
6FRK2.99628347
7NUAK12.92141588
8TRIM282.83011884
9MST42.72773457
10STK242.70571835
11NEK22.60316287
12WEE12.47057669
13PNCK2.37600845
14LATS12.32911056
15STK32.31130483
16CDC72.29807494
17TSSK62.13666934
18ALK2.08792139
19EIF2AK32.02494402
20PDGFRB2.00104593
21CHEK21.98182695
22MAP3K111.95409530
23ACVR1B1.92003814
24MKNK21.83658550
25MAP3K51.82443741
26CASK1.80732203
27MAP3K101.67717499
28TXK1.66179211
29ZAK1.60714364
30WNK31.56330310
31LATS21.54680380
32PDK21.51640250
33BCR1.51339186
34CDK61.50820835
35CDK71.49564629
36MAP2K41.46070259
37PLK31.46063215
38PLK41.42678651
39SIK31.42429506
40TAF11.41533807
41STK391.38951849
42ERBB41.37774639
43PDK41.36718361
44PDK31.36718361
45MAP3K131.36163441
46AKT31.35990082
47TYRO31.35033360
48MAP3K91.34259658
49BMPR1B1.34054881
50STK101.30438580
51ICK1.26386799
52EIF2AK11.26000793
53CDK41.24700737
54CHEK11.23268483
55DYRK31.22936648
56MAP3K61.22435235
57VRK11.22262586
58PIM11.18565594
59TAOK21.18367099
60STK161.15601661
61MELK1.14649825
62VRK21.06928037
63TTK1.05378974
64RPS6KA41.05039354
65BRD41.04929563
66NLK1.03341582
67MTOR1.03148133
68ERBB31.01440723
69JAK31.00152840
70STK38L1.00135562
71MAP4K10.99977189
72DMPK0.98971318
73MAP3K140.98962845
74EIF2AK20.98862710
75CSK0.96780204
76BRSK20.96079974
77BMX0.91972305
78KSR10.91213101
79CDK20.88868824
80CSNK1D0.87271423
81ATM0.86382564
82MARK30.86008531
83PLK10.85947231
84DDR20.84412014
85NEK60.83816383
86PLK20.83184944
87KSR20.80999428
88GSK3A0.80683860
89STK40.78724230
90BUB10.78242258
91PAK60.76265949
92FGR0.75399487
93OXSR10.75047141
94WNK40.74730644
95PRKD30.74002092
96FGFR20.72553172
97MAP3K40.70737957
98CHUK0.69579102
99TAOK30.68131725
100CDK10.67548642
101MAP3K20.67152879
102MAPK100.67020306
103MKNK10.65887923
104CSNK1G10.65878671
105ADRBK20.65590398
106FGFR10.64823025
107CSNK1E0.64012994
108STK110.62954889
109CSNK1G20.62664450
110JAK20.61775611
111PAK30.61616694
112GRK70.61260150
113CDK80.61188094
114GRK10.60860102
115PRKAA10.59581065
116GRK60.59328845
117PBK0.58645656
118CDK30.57609774
119WNK10.54257154
120BMPR20.54166106
121PRKAA20.52757033
122CAMK1G0.52228349
123MAP3K80.51611108
124MAPK140.50203937
125SRPK10.48704855
126YES10.47838683
127GSK3B0.46040631
128ATR0.45915906
129PRKCQ0.45873507
130SIK20.44881025
131PRKCG0.44758237
132TEC0.44298820
133SGK30.43678153
134RAF10.42764545
135STK380.42462458
136PRKCE0.41477061
137SGK10.41094034
138JAK10.40979967
139RPS6KA30.40413561
140MAPK130.40174959
141SIK10.40131646
142MAPK110.39910055
143NTRK20.39029922
144MAPK80.38972791
145CCNB10.38819398
146TGFBR20.37616101
147EEF2K0.35730884
148MUSK0.34597976
149EGFR0.34175052
150SGK20.34087183
151CSNK2A20.33863474
152ERBB20.33320336
153PRKG10.32187953
154FGFR30.30233353
155CSNK1G30.28181378
156PRKACB0.26577758
157TLK10.25155407

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.04864297
2Protein export_Homo sapiens_hsa030603.17565167
3Nitrogen metabolism_Homo sapiens_hsa009103.10245881
4Vitamin B6 metabolism_Homo sapiens_hsa007503.06599294
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.04243557
6RNA polymerase_Homo sapiens_hsa030202.68170944
7Folate biosynthesis_Homo sapiens_hsa007902.65922345
8Lysine degradation_Homo sapiens_hsa003102.57784656
9Arginine biosynthesis_Homo sapiens_hsa002202.54994119
10Non-homologous end-joining_Homo sapiens_hsa034502.37698734
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.35085465
12Proteasome_Homo sapiens_hsa030502.31541157
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.19211252
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17467958
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.09655961
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08883508
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85812426
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84276408
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.83295814
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67379123
21TGF-beta signaling pathway_Homo sapiens_hsa043501.50260514
22Mismatch repair_Homo sapiens_hsa034301.49773390
23RNA transport_Homo sapiens_hsa030131.49131549
24Selenocompound metabolism_Homo sapiens_hsa004501.49000110
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48862346
26Circadian rhythm_Homo sapiens_hsa047101.44907325
27Pentose phosphate pathway_Homo sapiens_hsa000301.38826631
28Complement and coagulation cascades_Homo sapiens_hsa046101.38650077
29mRNA surveillance pathway_Homo sapiens_hsa030151.35283867
30Phototransduction_Homo sapiens_hsa047441.31628588
31Caffeine metabolism_Homo sapiens_hsa002321.30804844
32Cell cycle_Homo sapiens_hsa041101.23048821
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.22437898
34Sulfur metabolism_Homo sapiens_hsa009201.22246299
35Nicotine addiction_Homo sapiens_hsa050331.21044613
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20598350
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19775890
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18824038
39Glioma_Homo sapiens_hsa052141.12774555
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11659142
41Steroid biosynthesis_Homo sapiens_hsa001001.10150397
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.08616393
43Nucleotide excision repair_Homo sapiens_hsa034201.06234565
44Histidine metabolism_Homo sapiens_hsa003401.05825798
45Biosynthesis of amino acids_Homo sapiens_hsa012301.04109956
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04002301
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03862293
48Oxidative phosphorylation_Homo sapiens_hsa001901.03409488
49mTOR signaling pathway_Homo sapiens_hsa041501.02463555
50Fatty acid biosynthesis_Homo sapiens_hsa000611.02172042
51Glycerolipid metabolism_Homo sapiens_hsa005611.01691470
52Fanconi anemia pathway_Homo sapiens_hsa034600.98176308
53Staphylococcus aureus infection_Homo sapiens_hsa051500.97612681
54MicroRNAs in cancer_Homo sapiens_hsa052060.94770565
55Prostate cancer_Homo sapiens_hsa052150.94625488
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94028380
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.90928151
58Vitamin digestion and absorption_Homo sapiens_hsa049770.90124943
59Amphetamine addiction_Homo sapiens_hsa050310.89466719
60Dorso-ventral axis formation_Homo sapiens_hsa043200.89176699
61Purine metabolism_Homo sapiens_hsa002300.89040921
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88665394
63Regulation of autophagy_Homo sapiens_hsa041400.86296176
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85096207
65PPAR signaling pathway_Homo sapiens_hsa033200.82560771
66Parkinsons disease_Homo sapiens_hsa050120.81969203
67Propanoate metabolism_Homo sapiens_hsa006400.78523217
68DNA replication_Homo sapiens_hsa030300.75299888
69Long-term potentiation_Homo sapiens_hsa047200.75199320
70Tryptophan metabolism_Homo sapiens_hsa003800.75178492
71Chronic myeloid leukemia_Homo sapiens_hsa052200.75165002
72Bile secretion_Homo sapiens_hsa049760.74635422
73One carbon pool by folate_Homo sapiens_hsa006700.73988940
74Fatty acid metabolism_Homo sapiens_hsa012120.71357734
75Carbon metabolism_Homo sapiens_hsa012000.68809459
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67743062
77Huntingtons disease_Homo sapiens_hsa050160.67350901
78T cell receptor signaling pathway_Homo sapiens_hsa046600.66115984
79Serotonergic synapse_Homo sapiens_hsa047260.64979876
80Basal transcription factors_Homo sapiens_hsa030220.64974073
81Olfactory transduction_Homo sapiens_hsa047400.63759682
82Homologous recombination_Homo sapiens_hsa034400.63523292
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63389075
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.62618679
85Oocyte meiosis_Homo sapiens_hsa041140.61968651
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61321805
87Ether lipid metabolism_Homo sapiens_hsa005650.60491717
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.60461174
89Pyrimidine metabolism_Homo sapiens_hsa002400.58145213
90Wnt signaling pathway_Homo sapiens_hsa043100.57788977
91Renal cell carcinoma_Homo sapiens_hsa052110.57340057
92Choline metabolism in cancer_Homo sapiens_hsa052310.57122941
93Dopaminergic synapse_Homo sapiens_hsa047280.57080863
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55656374
95B cell receptor signaling pathway_Homo sapiens_hsa046620.55542673
96Fatty acid degradation_Homo sapiens_hsa000710.55311265
97Legionellosis_Homo sapiens_hsa051340.55162027
98Linoleic acid metabolism_Homo sapiens_hsa005910.54278248
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54173109
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53933569
101Butanoate metabolism_Homo sapiens_hsa006500.53434927
102Collecting duct acid secretion_Homo sapiens_hsa049660.53208724
103Long-term depression_Homo sapiens_hsa047300.52684395
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.50820324
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49849735
106beta-Alanine metabolism_Homo sapiens_hsa004100.49247390
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48173544
108Glutamatergic synapse_Homo sapiens_hsa047240.47914499
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47793087
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46771124
111FoxO signaling pathway_Homo sapiens_hsa040680.46756023
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46301663
113Retinol metabolism_Homo sapiens_hsa008300.46292731
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46203978
115ErbB signaling pathway_Homo sapiens_hsa040120.45859580
116Estrogen signaling pathway_Homo sapiens_hsa049150.45856603
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45578385
118Fat digestion and absorption_Homo sapiens_hsa049750.45152813
119Renin secretion_Homo sapiens_hsa049240.43681113
120Phenylalanine metabolism_Homo sapiens_hsa003600.42974889
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42916870
122Adherens junction_Homo sapiens_hsa045200.42578356
123Epstein-Barr virus infection_Homo sapiens_hsa051690.42491129
124Non-small cell lung cancer_Homo sapiens_hsa052230.42390340
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.42371067
126Primary immunodeficiency_Homo sapiens_hsa053400.40704981
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39354145
128Small cell lung cancer_Homo sapiens_hsa052220.39142741
129Alzheimers disease_Homo sapiens_hsa050100.39109173
130Insulin resistance_Homo sapiens_hsa049310.38076728
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37489091
132Hepatitis B_Homo sapiens_hsa051610.37116389
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.36910434
134Antigen processing and presentation_Homo sapiens_hsa046120.36602410
135AMPK signaling pathway_Homo sapiens_hsa041520.36364408
136Colorectal cancer_Homo sapiens_hsa052100.36068215
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35203143
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35172746
139Glucagon signaling pathway_Homo sapiens_hsa049220.33781838
140Prolactin signaling pathway_Homo sapiens_hsa049170.33228663
141Herpes simplex infection_Homo sapiens_hsa051680.32804864
142Spliceosome_Homo sapiens_hsa030400.32272915
143p53 signaling pathway_Homo sapiens_hsa041150.32137207
144Inositol phosphate metabolism_Homo sapiens_hsa005620.32129415
145Peroxisome_Homo sapiens_hsa041460.32101148
146GABAergic synapse_Homo sapiens_hsa047270.30126574
147MAPK signaling pathway_Homo sapiens_hsa040100.29215817
148HTLV-I infection_Homo sapiens_hsa051660.28762911
149* RNA degradation_Homo sapiens_hsa030180.27002435
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25699133
151Hippo signaling pathway_Homo sapiens_hsa043900.25186298
152Chemical carcinogenesis_Homo sapiens_hsa052040.24450238
153Taste transduction_Homo sapiens_hsa047420.23926370
154Type II diabetes mellitus_Homo sapiens_hsa049300.23581572
155Metabolic pathways_Homo sapiens_hsa011000.21301146

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