PAPD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)5.72541261
2mitotic metaphase plate congression (GO:0007080)5.09864593
3monoubiquitinated protein deubiquitination (GO:0035520)4.89193056
4nuclear pore complex assembly (GO:0051292)4.67397712
5histone H2A monoubiquitination (GO:0035518)4.62067495
6regulation of histone H3-K9 methylation (GO:0051570)4.55226835
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.48668450
8cytoplasmic mRNA processing body assembly (GO:0033962)4.44977052
9regulation of meiosis (GO:0040020)4.43105575
10histone H3-K9 demethylation (GO:0033169)4.34612939
11regulation of acrosome reaction (GO:0060046)4.21119612
12oocyte development (GO:0048599)4.12948555
13nuclear pore organization (GO:0006999)4.11316456
14protein localization to kinetochore (GO:0034501)4.10565276
15protein kinase C signaling (GO:0070528)4.09393627
16metaphase plate congression (GO:0051310)4.09347264
17piRNA metabolic process (GO:0034587)4.07860236
18female gamete generation (GO:0007292)4.06728939
19mitotic sister chromatid cohesion (GO:0007064)4.06563826
20regulation of NFAT protein import into nucleus (GO:0051532)4.04395091
21positive regulation of humoral immune response (GO:0002922)4.03237009
22DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.98447031
23negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.97279996
24mitotic sister chromatid segregation (GO:0000070)3.95915025
25DNA damage response, signal transduction resulting in transcription (GO:0042772)3.93733175
26protein localization to chromosome, centromeric region (GO:0071459)3.88410889
27negative regulation of meiosis (GO:0045835)3.85587223
28regulation of spindle organization (GO:0090224)3.85303612
29regulation of sister chromatid cohesion (GO:0007063)3.85259799
30regulation of female gonad development (GO:2000194)3.83047179
31notochord development (GO:0030903)3.78670769
32regulation of clathrin-mediated endocytosis (GO:2000369)3.76692013
33regulation of DNA methylation (GO:0044030)3.75581636
34negative regulation of hormone metabolic process (GO:0032351)3.72555681
35negative regulation of hormone biosynthetic process (GO:0032353)3.72555681
36regulation of histone methylation (GO:0031060)3.71237578
37paraxial mesoderm development (GO:0048339)3.70913576
38establishment of chromosome localization (GO:0051303)3.68381470
39corticosteroid receptor signaling pathway (GO:0031958)3.67631445
40* mitotic chromosome condensation (GO:0007076)3.66722049
41histone H2A ubiquitination (GO:0033522)3.64190025
42attachment of spindle microtubules to kinetochore (GO:0008608)3.63836439
43histone H3-K36 demethylation (GO:0070544)3.57646825
44mitotic nuclear envelope disassembly (GO:0007077)3.57031611
45sister chromatid segregation (GO:0000819)3.56522133
46stress granule assembly (GO:0034063)3.56188990
47membrane disassembly (GO:0030397)3.53230823
48nuclear envelope disassembly (GO:0051081)3.53230823
49regulation of mitotic spindle organization (GO:0060236)3.52763128
50protein K6-linked ubiquitination (GO:0085020)3.49538505
51regulation of histone H3-K4 methylation (GO:0051569)3.47356636
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.46815111
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.46815111
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.46815111
55positive regulation of histone H3-K4 methylation (GO:0051571)3.45810521
56regulation of chromatin binding (GO:0035561)3.38859036
57protein localization to chromosome (GO:0034502)3.36530331
58regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.36486080
59regulation of meiotic cell cycle (GO:0051445)3.33918759
60negative regulation of histone methylation (GO:0031061)3.30999569
61negative regulation of circadian rhythm (GO:0042754)3.28402662
62chromosome segregation (GO:0007059)3.28183868
63oocyte maturation (GO:0001556)3.26519377
64negative regulation of histone modification (GO:0031057)3.25672582
65gene silencing by RNA (GO:0031047)3.25489358
66pore complex assembly (GO:0046931)3.22871687
67meiotic cell cycle (GO:0051321)3.20628826
68histone phosphorylation (GO:0016572)3.19925791
69histone H3-K4 methylation (GO:0051568)3.19076798
70negative regulation of meiotic cell cycle (GO:0051447)3.18669033
71pre-miRNA processing (GO:0031054)3.13181216
72positive regulation of chromosome segregation (GO:0051984)3.11739146
73male meiosis (GO:0007140)3.09297656
74RNA stabilization (GO:0043489)3.06199693
75mRNA stabilization (GO:0048255)3.06199693
76meiotic chromosome segregation (GO:0045132)3.05939389
77snRNA transcription (GO:0009301)3.05794355
78microtubule nucleation (GO:0007020)3.04188743
79histone H3-K4 trimethylation (GO:0080182)3.04167143
80regulation of meiosis I (GO:0060631)3.03477604
81folic acid-containing compound biosynthetic process (GO:0009396)3.01065376
82DNA damage induced protein phosphorylation (GO:0006975)3.01005728
83regulation of transforming growth factor beta2 production (GO:0032909)2.99753893
84intracellular estrogen receptor signaling pathway (GO:0030520)2.98111412
85nuclear envelope organization (GO:0006998)2.97716523
86regulation of RNA export from nucleus (GO:0046831)2.97617591
87regulation of histone H3-K27 methylation (GO:0061085)2.96767992
88kinetochore assembly (GO:0051382)2.96389141
89regulation of exit from mitosis (GO:0007096)2.94462912
90regulation of retinoic acid receptor signaling pathway (GO:0048385)2.94331773
91growth hormone receptor signaling pathway (GO:0060396)2.92365859
92activation of Rac GTPase activity (GO:0032863)2.92032789
93cytoskeleton-dependent cytokinesis (GO:0061640)2.91601806
94positive regulation of histone methylation (GO:0031062)2.89771984
95nucleus organization (GO:0006997)2.88176958
96N-terminal protein amino acid acetylation (GO:0006474)2.85985403
97inner cell mass cell proliferation (GO:0001833)2.85411946
98histone lysine demethylation (GO:0070076)2.83531408
99kinetochore organization (GO:0051383)2.81362328
100positive regulation of gene expression, epigenetic (GO:0045815)2.79911505
101chromatin assembly or disassembly (GO:0006333)2.79579448
102histone demethylation (GO:0016577)2.79024063
103DNA methylation involved in gamete generation (GO:0043046)2.78909765
104multicellular organism reproduction (GO:0032504)2.75738067
105positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.75523346
106negative regulation of smooth muscle cell differentiation (GO:0051151)2.75377846
107regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.74969145
108protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.74508557
109glucocorticoid receptor signaling pathway (GO:0042921)2.74086988
110establishment of mitotic spindle localization (GO:0040001)2.73808901
111nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.72396153
112response to UV-C (GO:0010225)2.72384630
113negative regulation of chromatin modification (GO:1903309)2.71554993
114regulation of steroid hormone secretion (GO:2000831)2.71179535
115regulation of establishment of cell polarity (GO:2000114)2.70458088
116regulation of chromosome segregation (GO:0051983)2.70452922
117regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.70255581
118synaptonemal complex assembly (GO:0007130)2.69943221
119negative regulation of reproductive process (GO:2000242)2.69407067
120regulation of glucocorticoid metabolic process (GO:0031943)2.64937376
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.61607205
122establishment of spindle localization (GO:0051293)2.61480080
123positive regulation of DNA-dependent DNA replication (GO:2000105)2.61348979
124positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.60304492
125protein monoubiquitination (GO:0006513)2.60223332
126spindle checkpoint (GO:0031577)2.59349549
127chromatin assembly (GO:0031497)2.58972924
128regulation of cell maturation (GO:1903429)2.58599748
129protein dealkylation (GO:0008214)2.58502384
130protein demethylation (GO:0006482)2.58502384
131negative regulation of cell aging (GO:0090344)2.58422844
132peptidyl-lysine dimethylation (GO:0018027)2.58252276
133regulation of steroid hormone biosynthetic process (GO:0090030)2.57368842
134regulation of nucleobase-containing compound transport (GO:0032239)2.55598801
135negative regulation of erythrocyte differentiation (GO:0045647)2.55535873
136histone monoubiquitination (GO:0010390)2.54147474
137gene silencing (GO:0016458)2.53739250
138regulation of early endosome to late endosome transport (GO:2000641)2.53537910
139interkinetic nuclear migration (GO:0022027)2.50361931
140establishment of mitotic spindle orientation (GO:0000132)2.49273707
141phosphatidylinositol dephosphorylation (GO:0046856)2.49168238
142establishment of spindle orientation (GO:0051294)2.46427436
143positive regulation of DNA-templated transcription, initiation (GO:2000144)2.44015150
144DNA alkylation (GO:0006305)2.42214107
145DNA methylation (GO:0006306)2.42214107
146spliceosomal tri-snRNP complex assembly (GO:0000244)2.40250407
147response to laminar fluid shear stress (GO:0034616)2.38086133
148peptidyl-threonine phosphorylation (GO:0018107)2.36055291
149negative regulation of DNA repair (GO:0045738)2.34620225
150citrulline biosynthetic process (GO:0019240)2.34147386
151protein localization to microtubule (GO:0035372)2.33045416
152cell-substrate adherens junction assembly (GO:0007045)2.33034571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.84725759
2E2F7_22180533_ChIP-Seq_HELA_Human5.16125543
3EZH2_22144423_ChIP-Seq_EOC_Human5.15212752
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.72790559
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.43490158
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.22946123
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08246306
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.84078701
9TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.75586530
10AR_21909140_ChIP-Seq_LNCAP_Human2.74797786
11VDR_21846776_ChIP-Seq_THP-1_Human2.68690322
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.64721832
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.48621917
14SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.44843532
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35360791
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32155285
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.25345210
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.16123133
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10222230
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.98449101
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.89098032
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.88731974
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.88174437
24MYC_22102868_ChIP-Seq_BL_Human1.83724838
25* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.82637523
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.79872680
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.79872680
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.79872680
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.78131109
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72737972
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70490955
32VDR_24763502_ChIP-Seq_THP-1_Human1.66119990
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.65380586
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64630956
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57182864
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56231775
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55650324
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53773827
39ATF3_27146783_Chip-Seq_COLON_Human1.52742176
40* KDM2B_26808549_Chip-Seq_K562_Human1.51772727
41* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51544851
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51485420
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51165291
44IGF1R_20145208_ChIP-Seq_DFB_Human1.50175514
45KDM2B_26808549_Chip-Seq_DND41_Human1.47465782
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46892523
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45488207
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44948563
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.40769520
50* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40667400
51* TCF7_22412390_ChIP-Seq_EML_Mouse1.40144660
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39058601
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37652081
54* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37592916
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35015117
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34670389
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.33590817
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32902466
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30961403
60RACK7_27058665_Chip-Seq_MCF-7_Human1.30455497
61NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30432906
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29546530
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28648967
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28469036
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25880148
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25785104
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25549569
68BRD4_25478319_ChIP-Seq_HGPS_Human1.24268330
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22235899
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22126280
71CLOCK_20551151_ChIP-Seq_293T_Human1.21920069
72MAF_26560356_Chip-Seq_TH1_Human1.21471474
73* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20713579
74LXR_22292898_ChIP-Seq_THP-1_Human1.20691965
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20425500
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19204704
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.18848980
78NCOR1_26117541_ChIP-Seq_K562_Human1.17992272
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16354478
80UTX_26944678_Chip-Seq_JUKART_Human1.16183056
81* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15958458
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15683904
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15494633
84FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.14558263
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.13581056
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12580682
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11676506
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11438650
89* RUNX1_22412390_ChIP-Seq_EML_Mouse1.10886198
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10545147
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09040061
92MYB_26560356_Chip-Seq_TH1_Human1.09022953
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07830201
94* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07772077
95RXR_22108803_ChIP-Seq_LS180_Human1.06991313
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06985518
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05407836
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05126593
99MAF_26560356_Chip-Seq_TH2_Human1.02770746
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01935666
101* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01657868
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01431558
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01286761
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01280801
105ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00939444
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00086916
107ISL1_27105846_Chip-Seq_CPCs_Mouse0.99762417
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99474036
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99474036
110ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98577987
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.97545998
112SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97144492
113POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97112621
114* ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97014144
115GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96223839
116TFEB_21752829_ChIP-Seq_HELA_Human0.94737330
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93751766
118MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93701550
119STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93593937
120PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93293681
121CREB1_26743006_Chip-Seq_LNCaP_Human0.92829875
122UBF1/2_26484160_Chip-Seq_HMECs_Human0.92752169
123STAT3_23295773_ChIP-Seq_U87_Human0.92633847
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92597610
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91410070
126KDM5A_27292631_Chip-Seq_BREAST_Human0.91243321
127MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90606001
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89987070
129TP53_16413492_ChIP-PET_HCT116_Human0.89519754
130CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89297345
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89133559
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88558910
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.88202362
134* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88033145
135SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87695872
136POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87535707
137FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87386656
138MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87370662
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86186340
140* SMC4_20622854_ChIP-Seq_HELA_Human0.85945194
141SCL_19346495_ChIP-Seq_HPC-7_Human0.85939825
142ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85855434
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85829169
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.85371235
145TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.85147140
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84833225
147BP1_19119308_ChIP-ChIP_Hs578T_Human0.84774125
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84395742
149AR_19668381_ChIP-Seq_PC3_Human0.82847373
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82213851
151TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82126177
152SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80036977
153GATA6_25053715_ChIP-Seq_YYC3_Human0.79403530
154TBX3_20139965_ChIP-Seq_MESCs_Mouse0.79230608
155PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78338771
156SMAD3_21741376_ChIP-Seq_HESCs_Human0.77887718
157TP63_23658742_ChIP-Seq_EP156T_Human0.77657019
158TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76739030
159WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76502595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.68389495
2MP0003705_abnormal_hypodermis_morpholog3.42235566
3MP0002653_abnormal_ependyma_morphology3.08124447
4MP0003718_maternal_effect3.05349070
5MP0003111_abnormal_nucleus_morphology2.83953680
6MP0003646_muscle_fatigue2.81757511
7MP0003077_abnormal_cell_cycle2.52670922
8MP0005408_hypopigmentation2.45811869
9MP0006292_abnormal_olfactory_placode2.38372729
10MP0005248_abnormal_Harderian_gland2.34355088
11MP0000566_synostosis2.31207637
12MP0005076_abnormal_cell_differentiation2.27282221
13MP0004185_abnormal_adipocyte_glucose2.26356785
14MP0003693_abnormal_embryo_hatching2.18033853
15MP0002877_abnormal_melanocyte_morpholog2.17178424
16MP0001849_ear_inflammation2.14102807
17MP0002139_abnormal_hepatobiliary_system2.12870211
18MP0003123_paternal_imprinting2.09011024
19MP0008877_abnormal_DNA_methylation2.07997421
20MP0009053_abnormal_anal_canal2.02535407
21MP0005257_abnormal_intraocular_pressure2.01772664
22MP0003787_abnormal_imprinting1.99014888
23MP0005409_darkened_coat_color1.98723301
24MP0010030_abnormal_orbit_morphology1.98328365
25MP0002102_abnormal_ear_morphology1.93797830
26MP0003890_abnormal_embryonic-extraembry1.90851791
27MP0003303_peritoneal_inflammation1.87935363
28MP0001915_intracranial_hemorrhage1.82755747
29MP0001119_abnormal_female_reproductive1.79736649
30MP0010094_abnormal_chromosome_stability1.76526866
31MP0010352_gastrointestinal_tract_polyps1.74802980
32MP0004957_abnormal_blastocyst_morpholog1.74464926
33MP0001730_embryonic_growth_arrest1.73123176
34MP0005395_other_phenotype1.73047124
35MP0010307_abnormal_tumor_latency1.72971237
36MP0003699_abnormal_female_reproductive1.72609645
37MP0000350_abnormal_cell_proliferation1.71813307
38MP0004510_myositis1.69923468
39MP0004808_abnormal_hematopoietic_stem1.69829880
40MP0008007_abnormal_cellular_replicative1.65664029
41MP0002084_abnormal_developmental_patter1.62956185
42MP0002796_impaired_skin_barrier1.62912249
43MP0000569_abnormal_digit_pigmentation1.60990223
44MP0002138_abnormal_hepatobiliary_system1.56099805
45MP0003937_abnormal_limbs/digits/tail_de1.54827943
46MP0005380_embryogenesis_phenotype1.54347567
47MP0001672_abnormal_embryogenesis/_devel1.54347567
48MP0001697_abnormal_embryo_size1.54131324
49MP0002085_abnormal_embryonic_tissue1.50908128
50MP0003121_genomic_imprinting1.45798902
51MP0003950_abnormal_plasma_membrane1.45298406
52MP0005310_abnormal_salivary_gland1.44487555
53MP0003755_abnormal_palate_morphology1.44094872
54MP0004233_abnormal_muscle_weight1.41356824
55MP0005058_abnormal_lysosome_morphology1.40616825
56MP0002396_abnormal_hematopoietic_system1.39841682
57MP0000579_abnormal_nail_morphology1.39473266
58MP0010234_abnormal_vibrissa_follicle1.37481667
59MP0003984_embryonic_growth_retardation1.35600703
60MP0005666_abnormal_adipose_tissue1.34845506
61MP0004264_abnormal_extraembryonic_tissu1.31796266
62MP0002088_abnormal_embryonic_growth/wei1.30562551
63MP0002249_abnormal_larynx_morphology1.29407868
64MP0004947_skin_inflammation1.26836311
65MP0002086_abnormal_extraembryonic_tissu1.26016301
66MP0003091_abnormal_cell_migration1.25593412
67MP0003183_abnormal_peptide_metabolism1.23936039
68MP0003763_abnormal_thymus_physiology1.23374293
69MP0004859_abnormal_synaptic_plasticity1.21542692
70MP0008932_abnormal_embryonic_tissue1.20889795
71MP0001348_abnormal_lacrimal_gland1.15924285
72MP0003385_abnormal_body_wall1.15505788
73MP0002089_abnormal_postnatal_growth/wei1.14558505
74MP0000678_abnormal_parathyroid_gland1.14342171
75MP0005501_abnormal_skin_physiology1.13258106
76MP0003879_abnormal_hair_cell1.11888675
77MP0000653_abnormal_sex_gland1.11797528
78MP0009840_abnormal_foam_cell1.11642667
79MP0003566_abnormal_cell_adhesion1.11364219
80MP0008789_abnormal_olfactory_epithelium1.09192753
81MP0003656_abnormal_erythrocyte_physiolo1.09018157
82MP0002210_abnormal_sex_determination1.07780710
83MP0005375_adipose_tissue_phenotype1.07274721
84MP0003436_decreased_susceptibility_to1.07076536
85MP0002163_abnormal_gland_morphology1.06816028
86MP0000639_abnormal_adrenal_gland1.06676444
87MP0003935_abnormal_craniofacial_develop1.05288529
88MP0000733_abnormal_muscle_development1.04446987
89MP0001346_abnormal_lacrimal_gland1.02992342
90MP0010368_abnormal_lymphatic_system1.02780516
91MP0005187_abnormal_penis_morphology1.01613586
92MP0001545_abnormal_hematopoietic_system1.00746922
93MP0005397_hematopoietic_system_phenotyp1.00746922
94MP0001929_abnormal_gametogenesis0.98854041
95MP0008057_abnormal_DNA_replication0.97777925
96MP0005621_abnormal_cell_physiology0.97444958
97MP0009672_abnormal_birth_weight0.97382347
98MP0003861_abnormal_nervous_system0.97346154
99MP0005384_cellular_phenotype0.95790312
100MP0000313_abnormal_cell_death0.94721608
101MP0002009_preneoplasia0.93232563
102MP0003300_gastrointestinal_ulcer0.92254859
103MP0000703_abnormal_thymus_morphology0.91565572
104MP0005394_taste/olfaction_phenotype0.90816327
105MP0005499_abnormal_olfactory_system0.90816327
106MP0009278_abnormal_bone_marrow0.89138536
107MP0002060_abnormal_skin_morphology0.88186278
108MP0002398_abnormal_bone_marrow0.87938195
109MP0002080_prenatal_lethality0.87083600
110MP0000003_abnormal_adipose_tissue0.86661202
111MP0002168_other_aberrant_phenotype0.86406922
112MP0000432_abnormal_head_morphology0.85561086
113MP0001853_heart_inflammation0.85489505
114MP0003252_abnormal_bile_duct0.84465233
115MP0005360_urolithiasis0.83243794
116MP0009250_abnormal_appendicular_skeleto0.83197552
117MP0002233_abnormal_nose_morphology0.82422059
118MP0008058_abnormal_DNA_repair0.81810531
119MP0002925_abnormal_cardiovascular_devel0.79946041
120MP0008260_abnormal_autophagy0.79799129
121MP0000762_abnormal_tongue_morphology0.79580494
122MP0002116_abnormal_craniofacial_bone0.79463733
123MP0000428_abnormal_craniofacial_morphol0.78841538
124MP0009333_abnormal_splenocyte_physiolog0.78636601
125MP0005197_abnormal_uvea_morphology0.77932941
126MP0002019_abnormal_tumor_incidence0.77899100
127MP0009115_abnormal_fat_cell0.77366374
128MP0002998_abnormal_bone_remodeling0.76715935
129MP0001216_abnormal_epidermal_layer0.75589899
130MP0010678_abnormal_skin_adnexa0.75143385
131MP0004381_abnormal_hair_follicle0.73426536
132MP0002161_abnormal_fertility/fecundity0.73293831
133MP0000627_abnormal_mammary_gland0.72983333
134MP0002177_abnormal_outer_ear0.72165600
135MP0000858_altered_metastatic_potential0.71402458
136MP0000767_abnormal_smooth_muscle0.71096433
137MP0004197_abnormal_fetal_growth/weight/0.70497720
138MP0003191_abnormal_cellular_cholesterol0.70476839
139MP0003453_abnormal_keratinocyte_physiol0.70194345
140MP0003115_abnormal_respiratory_system0.68418120
141MP0003221_abnormal_cardiomyocyte_apopto0.67943777
142MP0005023_abnormal_wound_healing0.66905161
143MP0001145_abnormal_male_reproductive0.66680973
144MP0008961_abnormal_basal_metabolism0.65168571
145MP0001851_eye_inflammation0.65037015

Predicted human phenotypes

RankGene SetZ-score
1Facial hemangioma (HP:0000329)6.33228610
2Abnormality of the labia minora (HP:0012880)4.33725320
3Papillary thyroid carcinoma (HP:0002895)4.29137603
4Male infertility (HP:0003251)4.19335918
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53923072
6Short 4th metacarpal (HP:0010044)3.53923072
7Abnormality of the fingertips (HP:0001211)3.43974348
8Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.39036132
9Short 1st metacarpal (HP:0010034)3.39036132
10Capillary hemangiomas (HP:0005306)3.33116604
11Shawl scrotum (HP:0000049)3.25526162
12Adrenal hypoplasia (HP:0000835)3.21233081
13Shallow orbits (HP:0000586)3.15944606
14Dysmetric saccades (HP:0000641)3.06822119
15Abnormality of the phalanges of the hallux (HP:0010057)3.04256818
16Microglossia (HP:0000171)3.03499669
17Oligodactyly (HP:0012165)3.03416757
18Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.99642871
19Aplasia/Hypoplasia of the sternum (HP:0006714)2.80985526
20Abnormality of the 1st metacarpal (HP:0010009)2.80325290
21Apathy (HP:0000741)2.79167730
22Rib fusion (HP:0000902)2.79113865
23Abnormality of the aortic arch (HP:0012303)2.78056595
24Abnormal gallbladder physiology (HP:0012438)2.75560562
25Cholecystitis (HP:0001082)2.75560562
26Truncal obesity (HP:0001956)2.72543188
27Abnormality of the 4th metacarpal (HP:0010012)2.67381174
28Flat acetabular roof (HP:0003180)2.58925061
29Diminished motivation (HP:0000745)2.56367663
30Increased density of long bones (HP:0006392)2.53929609
31Genu recurvatum (HP:0002816)2.52806980
32Increased connective tissue (HP:0009025)2.52089764
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50310564
34Ectopic kidney (HP:0000086)2.50240228
35Patellar aplasia (HP:0006443)2.49823920
36Impulsivity (HP:0100710)2.49134631
37Malnutrition (HP:0004395)2.49091331
38Autoimmune thrombocytopenia (HP:0001973)2.49074068
39Increased nuchal translucency (HP:0010880)2.47703775
40Hypoplastic labia majora (HP:0000059)2.45444295
41Uterine leiomyosarcoma (HP:0002891)2.44581115
42Leiomyosarcoma (HP:0100243)2.44581115
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.43604308
44Hepatoblastoma (HP:0002884)2.42989896
45Short phalanx of the thumb (HP:0009660)2.41064943
46Abnormality of the distal phalanx of the thumb (HP:0009617)2.39441117
47Hyperacusis (HP:0010780)2.39200829
48Thyroid carcinoma (HP:0002890)2.36793429
49Transitional cell carcinoma of the bladder (HP:0006740)2.36592489
50Birth length less than 3rd percentile (HP:0003561)2.35741408
51Broad thumb (HP:0011304)2.35587970
52Hyperglycemia (HP:0003074)2.35539907
53Breast aplasia (HP:0100783)2.33607632
54Aplasia/Hypoplasia of the patella (HP:0006498)2.29337444
55Neurofibrillary tangles (HP:0002185)2.27611537
56Peritonitis (HP:0002586)2.26548164
57Loss of speech (HP:0002371)2.26544067
58Abnormality of the metopic suture (HP:0005556)2.26294618
59Abnormality of the labia majora (HP:0012881)2.25796241
60Bladder neoplasm (HP:0009725)2.23719789
61Bladder carcinoma (HP:0002862)2.23719789
62Prostate neoplasm (HP:0100787)2.21635408
63Deep venous thrombosis (HP:0002625)2.19324780
64Abdominal situs inversus (HP:0003363)2.18471758
65Abnormality of abdominal situs (HP:0011620)2.18471758
66Sandal gap (HP:0001852)2.15555821
67Aplasia/Hypoplasia of the breasts (HP:0010311)2.13972796
68Trigonocephaly (HP:0000243)2.13340541
69Osteomalacia (HP:0002749)2.11542880
70Chromsome breakage (HP:0040012)2.10953365
71Dislocated radial head (HP:0003083)2.09255087
72Enlarged penis (HP:0000040)2.08272449
73Hypercortisolism (HP:0001578)2.07999417
74Lower limb hyperreflexia (HP:0002395)2.05839523
75Supranuclear gaze palsy (HP:0000605)2.04938786
76Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.04730657
77Camptodactyly of toe (HP:0001836)2.03985640
78Cerebral inclusion bodies (HP:0100314)2.03260324
79Long palpebral fissure (HP:0000637)2.02644089
80Abnormality of lateral ventricle (HP:0030047)2.01290014
81Gastrointestinal infarctions (HP:0005244)2.00087820
82Spinal cord compression (HP:0002176)1.99093552
83Broad face (HP:0000283)1.97590899
84Slow saccadic eye movements (HP:0000514)1.96262963
85Sparse lateral eyebrow (HP:0005338)1.95863035
86Volvulus (HP:0002580)1.93450431
87Acute myeloid leukemia (HP:0004808)1.93056937
88Heterotopia (HP:0002282)1.92353708
89Milia (HP:0001056)1.92100849
90Ankyloglossia (HP:0010296)1.91289771
91Breast hypoplasia (HP:0003187)1.91249377
92Abnormality of chromosome segregation (HP:0002916)1.89727518
93Ulnar bowing (HP:0003031)1.88442544
94Cortical dysplasia (HP:0002539)1.87929731
95Myocardial infarction (HP:0001658)1.87677239
96Vertebral arch anomaly (HP:0008438)1.87381514
97Abnormality of the radial head (HP:0003995)1.85891799
98Gastrointestinal carcinoma (HP:0002672)1.85823939
99Malignant gastrointestinal tract tumors (HP:0006749)1.85823939
100Nuclear cataract (HP:0100018)1.84304726
101Abnormality of the salivary glands (HP:0010286)1.83413231
102Premature ovarian failure (HP:0008209)1.83108373
103Abnormality of the labia (HP:0000058)1.82623479
104Upper limb amyotrophy (HP:0009129)1.82592490
105Distal upper limb amyotrophy (HP:0007149)1.82592490
106Abnormality of the diencephalon (HP:0010662)1.81626702
107Syringomyelia (HP:0003396)1.81618927
108Spinal cord lesions (HP:0100561)1.81618927
109Renovascular hypertension (HP:0100817)1.81283103
110Spontaneous abortion (HP:0005268)1.80683255
111Overlapping toe (HP:0001845)1.79940492
112Deep philtrum (HP:0002002)1.78745793
113Deviation of the thumb (HP:0009603)1.78301819
114Abnormality of the lower motor neuron (HP:0002366)1.77959791
115Broad phalanges of the hand (HP:0009768)1.77362060
116Obstructive sleep apnea (HP:0002870)1.76842852
117Fatigue (HP:0012378)1.76785330
118Cubitus valgus (HP:0002967)1.76119739
119Broad hallux (HP:0010055)1.75063455
120Disproportionate tall stature (HP:0001519)1.74881722
121Neuronal loss in central nervous system (HP:0002529)1.74340714
122Cranial hyperostosis (HP:0004437)1.74308344
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73380337
124Renal cell carcinoma (HP:0005584)1.73074287
125Cafe-au-lait spot (HP:0000957)1.71831505
126Lip pit (HP:0100267)1.71647084
127Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71066812
128Natal tooth (HP:0000695)1.70387525
129Neonatal death (HP:0003811)1.69841409
130Flat capital femoral epiphysis (HP:0003370)1.69658727
131Arterial tortuosity (HP:0005116)1.69414517
132Hemivertebrae (HP:0002937)1.69284277
133Abnormality of the intervertebral disk (HP:0005108)1.67994917
134Proximal placement of thumb (HP:0009623)1.67933626
135Broad finger (HP:0001500)1.66220278
136Long eyelashes (HP:0000527)1.65626317
137Oligodactyly (hands) (HP:0001180)1.64935925
138Complete atrioventricular canal defect (HP:0001674)1.64511373
139Conjunctival telangiectasia (HP:0000524)1.64307943
140Protrusio acetabuli (HP:0003179)1.64218395
141Subacute progressive viral hepatitis (HP:0006572)1.63821648
142Ankle contracture (HP:0006466)1.62911087
143Long toe (HP:0010511)1.62598506
144Obsessive-compulsive behavior (HP:0000722)1.62577763
145Urethral obstruction (HP:0000796)1.62105528
146Abnormality of monocarboxylic acid metabolism (HP:0010996)1.61780550
147Low anterior hairline (HP:0000294)1.61115666
148Abnormal foot bone ossification (HP:0010675)1.60339382
149Deep palmar crease (HP:0006191)1.60326039
150Thick nail (HP:0001805)1.59853274
151Polycythemia (HP:0001901)1.59699644
152Thin bony cortex (HP:0002753)1.58806358
153Broad phalanx (HP:0006009)1.58158880
154Hypoplastic female external genitalia (HP:0012815)1.57589811
155Short thumb (HP:0009778)1.56880230
156Bowel incontinence (HP:0002607)1.56827812
157Abnormal ossification of hand bones (HP:0005921)1.56580773
158Cystic hygroma (HP:0000476)1.56480306
159Abnormality of the thoracic spine (HP:0100711)1.56239886
160Distal lower limb amyotrophy (HP:0008944)1.56219093
161Bicornuate uterus (HP:0000813)1.56175625
162Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.56044095
163Insomnia (HP:0100785)1.55244555
164Labial hypoplasia (HP:0000066)1.54831945
165Skin pits (HP:0100276)1.54432139
166Hydroureter (HP:0000072)1.54197085
167Abnormality of oral frenula (HP:0000190)1.53888397
168Craniofacial hyperostosis (HP:0004493)1.53839676
169Hypochromic microcytic anemia (HP:0004840)1.53706092
170Elbow flexion contracture (HP:0002987)1.53355844
171Progressive external ophthalmoplegia (HP:0000590)1.53007085
172Hypophosphatemic rickets (HP:0004912)1.51262688
173Abnormal large intestine physiology (HP:0012700)1.50877243
174Cerebral aneurysm (HP:0004944)1.49915443
175Mitral valve prolapse (HP:0001634)1.49804728
176Muscle stiffness (HP:0003552)1.47697254
177Abnormality of the vasculature of the conjunctiva (HP:0008054)1.47376511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.97403274
2LATS25.41134502
3STK38L4.51441342
4PRPF4B3.02612660
5TAOK12.80856519
6KSR22.61848645
7MAP3K62.53384111
8ICK2.51514827
9MOS2.41427995
10CDC72.32851448
11ERBB42.31663937
12STK32.31593817
13MAP3K92.31229240
14BMPR22.30010757
15IRAK32.12060909
16TAOK32.11749405
17CDK122.10134230
18PRKD32.07479441
19PLK41.88768020
20STK381.82970959
21NEK61.70657876
22PAK61.69807820
23TRIB31.66744842
24NEK21.59738534
25TTK1.51032378
26ABL21.50847259
27MAP3K101.50514059
28RAF11.50144802
29MAP3K141.48582503
30MAP3K131.47325680
31SMG11.45671125
32SIK11.40054314
33KSR11.30843735
34CAMK1D1.29306292
35MET1.25913088
36TYRO31.24891607
37SIK21.22009747
38MAP3K41.20712649
39CAMK1G1.20488018
40DYRK21.12716769
41CDK81.12185270
42CHEK21.10660860
43JAK31.09013020
44ERN11.08432111
45PKN21.07564903
46MELK1.06220664
47ARAF1.04781085
48EEF2K1.03013889
49TRPM70.99026143
50CDK90.95860279
51RET0.95799434
52DMPK0.95745532
53MAP2K30.95648988
54BRAF0.91818339
55FGFR40.90152305
56WNK10.88853151
57TTN0.88663430
58CLK10.87404426
59TAOK20.87086779
60CDC42BPA0.85596406
61MST1R0.79813881
62MAP3K50.79081385
63PRKD20.75575918
64PDGFRA0.75337967
65CDK40.72124592
66PDGFRB0.71347936
67NEK90.70666122
68RPS6KB20.68195820
69PLK10.67265911
70MAP2K40.67104075
71STK100.66416825
72IRAK20.65052418
73BMX0.63364954
74MARK30.60970499
75CHEK10.60213601
76PDPK10.59704294
77IRAK40.59461296
78MAP3K30.57510152
79PLK20.56441291
80PRKAA10.55349600
81CSNK1G20.53194926
82MARK20.52772403
83SGK20.52191289
84SGK30.51113553
85MAP3K80.50985976
86STK240.50971856
87PDK10.50898870
88PIM10.50880342
89AURKB0.50786761
90CSNK1G10.50670303
91ZAP700.50363722
92ABL10.50311893
93PRKCH0.49514485
94ATM0.48408371
95CHUK0.47519722
96TBK10.46525987
97NME20.45360960
98PTK20.44993708
99FGFR30.44971501
100MAPK130.44359931
101MTOR0.44077034
102LRRK20.43961656
103HIPK20.43557046
104CDK20.42616606
105ALK0.41224204
106NUAK10.40689543
107FGR0.40207070
108NTRK20.37654039
109EPHB10.37472225
110MAP3K70.37304677
111MAPK100.36595873
112MAPK10.36577359
113CAMKK10.36443755
114JAK20.36242108
115ATR0.35160982
116DDR20.33863955
117CSNK1D0.33416198
118NEK10.32333221
119STK110.32285828
120CDK10.32003890
121MAP4K10.30768764
122PRKCI0.30643305
123BRSK10.30501245
124MAPK110.29445849
125RPS6KA40.29393894
126MAP2K70.29176784
127CDK70.29049960
128PLK30.28497205
129CDK60.27860931
130NTRK30.27743763
131BRD40.25145040
132MARK10.24936968
133TYK20.24390277
134SGK10.24139922
135MAPK140.23873729
136EPHA40.23502049
137AKT10.21232951
138NLK0.20678477
139GSK3B0.20326315
140RIPK10.19236696
141MAP3K10.18720189
142AURKA0.18026697
143PAK30.17484789

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.44726250
2Pancreatic cancer_Homo sapiens_hsa052122.09398244
3Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.03791286
4Ovarian steroidogenesis_Homo sapiens_hsa049131.98596184
5MicroRNAs in cancer_Homo sapiens_hsa052061.89608784
6mTOR signaling pathway_Homo sapiens_hsa041501.88326104
7Dorso-ventral axis formation_Homo sapiens_hsa043201.87368197
8Prolactin signaling pathway_Homo sapiens_hsa049171.82082743
9TGF-beta signaling pathway_Homo sapiens_hsa043501.69570691
10Oocyte meiosis_Homo sapiens_hsa041141.67386307
11Circadian rhythm_Homo sapiens_hsa047101.66575188
12B cell receptor signaling pathway_Homo sapiens_hsa046621.61186627
13Colorectal cancer_Homo sapiens_hsa052101.56581860
14p53 signaling pathway_Homo sapiens_hsa041151.56383066
15Adherens junction_Homo sapiens_hsa045201.55916202
16Chronic myeloid leukemia_Homo sapiens_hsa052201.54661310
17Endometrial cancer_Homo sapiens_hsa052131.46884319
18Renal cell carcinoma_Homo sapiens_hsa052111.44100415
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38865762
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36218040
21Non-small cell lung cancer_Homo sapiens_hsa052231.36010468
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34898273
23Glioma_Homo sapiens_hsa052141.33854677
24DNA replication_Homo sapiens_hsa030301.30354881
25Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28984707
26Prion diseases_Homo sapiens_hsa050201.27759865
27GnRH signaling pathway_Homo sapiens_hsa049121.26186213
28Basal transcription factors_Homo sapiens_hsa030221.24055974
29TNF signaling pathway_Homo sapiens_hsa046681.22847594
30Lysine degradation_Homo sapiens_hsa003101.20964438
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.20788427
32VEGF signaling pathway_Homo sapiens_hsa043701.19346738
33Choline metabolism in cancer_Homo sapiens_hsa052311.18855084
34T cell receptor signaling pathway_Homo sapiens_hsa046601.18812557
35Thyroid cancer_Homo sapiens_hsa052161.17989953
36Hippo signaling pathway_Homo sapiens_hsa043901.17857070
37Inositol phosphate metabolism_Homo sapiens_hsa005621.17492315
38FoxO signaling pathway_Homo sapiens_hsa040681.17459648
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16970110
40* RNA degradation_Homo sapiens_hsa030181.16961502
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16910086
42ErbB signaling pathway_Homo sapiens_hsa040121.15143289
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13034273
44Bladder cancer_Homo sapiens_hsa052191.11343650
45Hepatitis B_Homo sapiens_hsa051611.10493960
46Prostate cancer_Homo sapiens_hsa052151.08046089
47Herpes simplex infection_Homo sapiens_hsa051681.06882016
48Measles_Homo sapiens_hsa051621.06718732
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05873257
50RNA transport_Homo sapiens_hsa030131.03658945
51Small cell lung cancer_Homo sapiens_hsa052221.02706035
52Notch signaling pathway_Homo sapiens_hsa043300.98986535
53Influenza A_Homo sapiens_hsa051640.98263048
54mRNA surveillance pathway_Homo sapiens_hsa030150.97930846
55Base excision repair_Homo sapiens_hsa034100.96497387
56Type II diabetes mellitus_Homo sapiens_hsa049300.95214820
57Estrogen signaling pathway_Homo sapiens_hsa049150.94386063
58Hepatitis C_Homo sapiens_hsa051600.93040559
59Mismatch repair_Homo sapiens_hsa034300.91893899
60Shigellosis_Homo sapiens_hsa051310.91460857
61Other glycan degradation_Homo sapiens_hsa005110.88502023
62MAPK signaling pathway_Homo sapiens_hsa040100.86898477
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.86726792
64Epstein-Barr virus infection_Homo sapiens_hsa051690.83787487
65Insulin resistance_Homo sapiens_hsa049310.83763886
66Arginine biosynthesis_Homo sapiens_hsa002200.83212513
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82077694
68Melanoma_Homo sapiens_hsa052180.81095189
69Vitamin B6 metabolism_Homo sapiens_hsa007500.81000992
70HIF-1 signaling pathway_Homo sapiens_hsa040660.80225734
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79722183
72Viral myocarditis_Homo sapiens_hsa054160.79574907
73Amoebiasis_Homo sapiens_hsa051460.77283048
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76659937
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76191070
76Gap junction_Homo sapiens_hsa045400.75206920
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73611805
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73430179
79Proteoglycans in cancer_Homo sapiens_hsa052050.73196304
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72181688
81HTLV-I infection_Homo sapiens_hsa051660.72145405
82Toxoplasmosis_Homo sapiens_hsa051450.71516655
83Long-term potentiation_Homo sapiens_hsa047200.70998136
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.70964774
85Ras signaling pathway_Homo sapiens_hsa040140.68571270
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67157306
87Chemokine signaling pathway_Homo sapiens_hsa040620.66251169
88Hedgehog signaling pathway_Homo sapiens_hsa043400.65990988
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65709906
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.64117245
91Tuberculosis_Homo sapiens_hsa051520.63535686
92Insulin signaling pathway_Homo sapiens_hsa049100.62899860
93Leishmaniasis_Homo sapiens_hsa051400.62414261
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.62132219
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61979257
96Long-term depression_Homo sapiens_hsa047300.61961068
97AMPK signaling pathway_Homo sapiens_hsa041520.60595636
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58949868
99cAMP signaling pathway_Homo sapiens_hsa040240.58551574
100Type I diabetes mellitus_Homo sapiens_hsa049400.57784248
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57590864
102Nucleotide excision repair_Homo sapiens_hsa034200.57378614
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57123942
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56570610
105Spliceosome_Homo sapiens_hsa030400.56357956
106Rap1 signaling pathway_Homo sapiens_hsa040150.55974398
107Acute myeloid leukemia_Homo sapiens_hsa052210.55883984
108Olfactory transduction_Homo sapiens_hsa047400.54481195
109Osteoclast differentiation_Homo sapiens_hsa043800.54174993
110Viral carcinogenesis_Homo sapiens_hsa052030.53269858
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52003833
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51636133
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.50605376
114Malaria_Homo sapiens_hsa051440.49137201
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48900557
116Pathways in cancer_Homo sapiens_hsa052000.48195427
117Focal adhesion_Homo sapiens_hsa045100.48122701
118Apoptosis_Homo sapiens_hsa042100.47959169
119Cholinergic synapse_Homo sapiens_hsa047250.47261942
120Wnt signaling pathway_Homo sapiens_hsa043100.47232568
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.47117992
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.46894544
123Staphylococcus aureus infection_Homo sapiens_hsa051500.46392292
124Nitrogen metabolism_Homo sapiens_hsa009100.45685879
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45637771

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