PAPLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.65848364
2tooth mineralization (GO:0034505)6.40611210
3negative regulation of T cell differentiation in thymus (GO:0033085)6.12774171
4type B pancreatic cell proliferation (GO:0044342)5.37723156
5bundle of His cell to Purkinje myocyte communication (GO:0086069)5.21757515
6positive regulation of transcription from RNA polymerase III promoter (GO:0045945)5.16812594
7pattern specification involved in kidney development (GO:0061004)4.97524756
8behavioral response to nicotine (GO:0035095)4.65915904
9fucose catabolic process (GO:0019317)4.63434497
10L-fucose metabolic process (GO:0042354)4.63434497
11L-fucose catabolic process (GO:0042355)4.63434497
12odontogenesis of dentin-containing tooth (GO:0042475)4.55351700
13peptidyl-proline hydroxylation (GO:0019511)4.51691157
144-hydroxyproline metabolic process (GO:0019471)4.48849556
15cell-substrate junction assembly (GO:0007044)4.42892759
16desmosome organization (GO:0002934)4.22443507
17gas transport (GO:0015669)4.20334061
18gamma-aminobutyric acid transport (GO:0015812)4.11450933
19positive regulation of odontogenesis (GO:0042482)4.08558372
20indole-containing compound catabolic process (GO:0042436)4.06517378
21indolalkylamine catabolic process (GO:0046218)4.06517378
22tryptophan catabolic process (GO:0006569)4.06517378
23negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.05907803
24odontogenesis (GO:0042476)4.03040948
25DNA deamination (GO:0045006)3.83661986
26protein hydroxylation (GO:0018126)3.81864311
27endodermal cell differentiation (GO:0035987)3.66218318
28regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.63428551
29negative regulation of smooth muscle cell migration (GO:0014912)3.60725378
30ventricular cardiac muscle cell action potential (GO:0086005)3.58893722
31branching involved in salivary gland morphogenesis (GO:0060445)3.52856606
32cytoskeletal anchoring at plasma membrane (GO:0007016)3.48202572
33glomerular filtration (GO:0003094)3.48161499
34neuromuscular junction development (GO:0007528)3.47729054
35negative regulation of potassium ion transmembrane transport (GO:1901380)3.46867686
36sarcomere organization (GO:0045214)3.45560246
37indolalkylamine metabolic process (GO:0006586)3.45015215
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.44191616
39negative regulation of translation, ncRNA-mediated (GO:0040033)3.44191616
40regulation of translation, ncRNA-mediated (GO:0045974)3.44191616
41growth hormone receptor signaling pathway (GO:0060396)3.38379416
42one-carbon compound transport (GO:0019755)3.35899662
43positive regulation of fatty acid transport (GO:2000193)3.32593112
44tryptophan metabolic process (GO:0006568)3.30749320
45sulfation (GO:0051923)3.29894075
46kynurenine metabolic process (GO:0070189)3.29586764
47heart trabecula formation (GO:0060347)3.26568282
48kidney morphogenesis (GO:0060993)3.20632214
49camera-type eye morphogenesis (GO:0048593)3.20323238
50cell communication involved in cardiac conduction (GO:0086065)3.20085119
51regulation of cytokine production involved in inflammatory response (GO:1900015)3.19800033
52positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.14717276
53extracellular matrix disassembly (GO:0022617)3.14615023
54positive regulation of antigen processing and presentation (GO:0002579)3.14070654
55epithelial cell-cell adhesion (GO:0090136)3.14062116
56peripheral nervous system development (GO:0007422)3.12406022
57plasma membrane repair (GO:0001778)3.09535295
58regulation of mesoderm development (GO:2000380)3.07858130
59dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.03110249
60regulation of cardioblast differentiation (GO:0051890)3.02443218
61cardiac myofibril assembly (GO:0055003)3.01467080
62somatic stem cell division (GO:0048103)3.00809485
63segment specification (GO:0007379)2.99006588
64positive regulation of defense response to virus by host (GO:0002230)2.98758545
65regulation of p38MAPK cascade (GO:1900744)2.98403124
66positive regulation of icosanoid secretion (GO:0032305)2.97915442
67regulation of gene silencing by RNA (GO:0060966)2.97597893
68regulation of posttranscriptional gene silencing (GO:0060147)2.97597893
69regulation of gene silencing by miRNA (GO:0060964)2.97597893
70phosphatidylinositol 3-kinase signaling (GO:0014065)2.95265263
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94362184
72positive regulation of histone deacetylation (GO:0031065)2.93550761
73biomineral tissue development (GO:0031214)2.92865574
74positive regulation of respiratory burst (GO:0060267)2.89972802
75cAMP catabolic process (GO:0006198)2.85100970
76T-helper 1 type immune response (GO:0042088)2.84684117
77negative regulation of fatty acid transport (GO:2000192)2.83536130
78cellular response to growth hormone stimulus (GO:0071378)2.83367661
79fucosylation (GO:0036065)2.77792011
80retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77034625
81cell adhesion mediated by integrin (GO:0033627)2.76416670
82positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.76082179
83renal system development (GO:0072001)2.74992779
84regulation of cell fate specification (GO:0042659)2.74748477
85negative regulation of reactive oxygen species metabolic process (GO:2000378)2.74271004
86iron ion import (GO:0097286)2.74134546
87regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71453556
88phosphatidylinositol acyl-chain remodeling (GO:0036149)2.70986830
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70765390
90positive regulation of glycoprotein biosynthetic process (GO:0010560)2.70746878
91positive regulation of p38MAPK cascade (GO:1900745)2.70147691
92somite development (GO:0061053)2.68127172
93trabecula formation (GO:0060343)2.67817057
94regulation of triglyceride biosynthetic process (GO:0010866)2.67667015
95collagen catabolic process (GO:0030574)2.66420946
96positive regulation of developmental pigmentation (GO:0048087)2.65804095
97complement activation, classical pathway (GO:0006958)2.65699458
98regulation of odontogenesis (GO:0042481)2.64708479
99mesodermal cell differentiation (GO:0048333)2.64690956
100regulation of dendritic cell antigen processing and presentation (GO:0002604)2.63881063
101positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.61769578
102atrial cardiac muscle cell action potential (GO:0086014)2.61732054
103collagen metabolic process (GO:0032963)2.61236651
104nephron epithelium morphogenesis (GO:0072088)2.61116479
105nephron tubule morphogenesis (GO:0072078)2.61116479
106basement membrane organization (GO:0071711)2.59278288
107negative regulation of systemic arterial blood pressure (GO:0003085)2.59066697
108cornea development in camera-type eye (GO:0061303)2.59041670
109regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58825688
110cellular response to sterol (GO:0036315)2.58707282
111epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57766736
112regulation of transcription from RNA polymerase I promoter (GO:0006356)2.57569805
113embryonic retina morphogenesis in camera-type eye (GO:0060059)2.57398781
114mammary gland epithelial cell proliferation (GO:0033598)2.56806480
115thyroid hormone metabolic process (GO:0042403)2.56348609
116keratinocyte development (GO:0003334)2.56299985
117ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.56172889
118positive regulation of heat generation (GO:0031652)2.55525694
119regulation of cellular extravasation (GO:0002691)2.55303792
120drug catabolic process (GO:0042737)2.54991535
121detection of light stimulus involved in sensory perception (GO:0050962)2.54687195
122detection of light stimulus involved in visual perception (GO:0050908)2.54687195
123positive regulation of protein kinase C signaling (GO:0090037)2.54680173
124cyclic nucleotide catabolic process (GO:0009214)2.54632700
125negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54298441
126lung-associated mesenchyme development (GO:0060484)2.54209098
127multicellular organismal macromolecule metabolic process (GO:0044259)2.53844924
128head development (GO:0060322)2.52250061
129regulation of transcription from RNA polymerase III promoter (GO:0006359)2.52243155
130negative regulation of telomere maintenance (GO:0032205)2.52092979
131positive regulation of triglyceride biosynthetic process (GO:0010867)2.50606656
132multicellular organismal catabolic process (GO:0044243)2.50533654
133wound healing (GO:0042060)2.49613063
134regulation of guanylate cyclase activity (GO:0031282)2.49308540
135phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.48618992
136oligodendrocyte differentiation (GO:0048709)2.48260411
137positive regulation of collagen biosynthetic process (GO:0032967)2.48118911
138paraxial mesoderm development (GO:0048339)2.47534336
139cytidine metabolic process (GO:0046087)2.45895470
140cytidine catabolic process (GO:0006216)2.45895470
141cytidine deamination (GO:0009972)2.45895470
142indole-containing compound metabolic process (GO:0042430)2.45612617
143cardiovascular system development (GO:0072358)2.45295121
144regulation of pigment cell differentiation (GO:0050932)2.45087187
145myofibril assembly (GO:0030239)2.44803121
146regulation of cGMP biosynthetic process (GO:0030826)2.44491411
147lymphangiogenesis (GO:0001946)2.44294591
148actomyosin structure organization (GO:0031032)2.44238387
149carnitine shuttle (GO:0006853)2.43980529
150exogenous drug catabolic process (GO:0042738)2.43146826
151positive regulation of T-helper 1 type immune response (GO:0002827)2.42786117
152regulation of antigen processing and presentation (GO:0002577)2.42338028
153cardiac muscle cell action potential involved in contraction (GO:0086002)2.40984269
154collecting duct development (GO:0072044)2.40960944
155cardiac muscle contraction (GO:0060048)2.40900302
156regulation of heat generation (GO:0031650)2.40837214
157renal filtration (GO:0097205)2.40700889
158regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.40532494
159regulation of cGMP metabolic process (GO:0030823)2.40475715
160regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.40192276
161cytokine biosynthetic process (GO:0042089)2.39695706
162insulin-like growth factor receptor signaling pathway (GO:0048009)2.39686643
163proline transport (GO:0015824)2.39553225
164NAD biosynthetic process (GO:0009435)2.39484868
165alanine transport (GO:0032328)2.39260950
166regulation of hippo signaling (GO:0035330)2.38715035
167water-soluble vitamin biosynthetic process (GO:0042364)2.38595158
168platelet dense granule organization (GO:0060155)2.37966808
169multicellular organismal metabolic process (GO:0044236)2.37924446
170positive regulation of collagen metabolic process (GO:0010714)2.37757054
171cell migration involved in sprouting angiogenesis (GO:0002042)2.37394534
172fatty acid transmembrane transport (GO:1902001)2.37252564
173somite rostral/caudal axis specification (GO:0032525)2.37248278
174phosphatidylserine acyl-chain remodeling (GO:0036150)2.37204993
175cellular response to ATP (GO:0071318)2.36964007
176regulation of heart rate by cardiac conduction (GO:0086091)2.35794497
177alkaloid metabolic process (GO:0009820)2.34382761
178positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.33854905
179positive regulation of cGMP biosynthetic process (GO:0030828)2.33401931
180cardiac muscle cell action potential (GO:0086001)2.33382320
181adaptation of signaling pathway (GO:0023058)2.33153894
182cellular response to cadmium ion (GO:0071276)2.33052618
183regulation of collagen biosynthetic process (GO:0032965)2.32889515
184thyroid hormone generation (GO:0006590)2.32793800
185protein localization to endosome (GO:0036010)2.32722781
186basic amino acid transport (GO:0015802)2.32665226
187regulation of interleukin-6 biosynthetic process (GO:0045408)2.31796812
188bone remodeling (GO:0046849)2.31775624
189cardiac muscle tissue morphogenesis (GO:0055008)2.31729462
190positive regulation of guanylate cyclase activity (GO:0031284)2.31600039
191polarized epithelial cell differentiation (GO:0030859)2.31445316
192face morphogenesis (GO:0060325)2.31081136
193cell junction organization (GO:0034330)2.30850652
194amine catabolic process (GO:0009310)2.30698313
195cellular biogenic amine catabolic process (GO:0042402)2.30698313
196negative regulation of cardiac muscle tissue growth (GO:0055022)2.29017811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.28725958
2ZNF263_19887448_ChIP-Seq_K562_Human4.82649909
3ZNF274_21170338_ChIP-Seq_K562_Hela3.39733611
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.15260722
5VDR_22108803_ChIP-Seq_LS180_Human3.12627550
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.02192075
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73581825
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.63537370
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.62298045
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.61579378
11GBX2_23144817_ChIP-Seq_PC3_Human2.60723608
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.46535703
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39318439
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36672162
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32815753
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32458160
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.19456248
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09861813
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08386857
20EZH2_22144423_ChIP-Seq_EOC_Human1.98915001
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95661581
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91458932
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87036391
24CLOCK_20551151_ChIP-Seq_293T_Human1.86854522
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80708998
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80250059
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75902860
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.75563508
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75312084
30* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.72808573
31AHR_22903824_ChIP-Seq_MCF-7_Human1.71698878
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70843333
33P300_19829295_ChIP-Seq_ESCs_Human1.69395125
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.67890327
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67399066
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67018246
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65113576
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.64413582
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.64413582
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63397950
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61175371
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59431741
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.59276568
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58491476
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55326227
46IGF1R_20145208_ChIP-Seq_DFB_Human1.54717814
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.54710246
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54520375
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54317710
50BCAT_22108803_ChIP-Seq_LS180_Human1.52192788
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50210572
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.50024702
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46281103
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.45437477
55RACK7_27058665_Chip-Seq_MCF-7_Human1.44954353
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.44007715
57* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42830769
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42501776
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41376213
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41376213
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.40889032
62FUS_26573619_Chip-Seq_HEK293_Human1.40729492
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40067778
64AR_21572438_ChIP-Seq_LNCaP_Human1.39065409
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37159534
66RXR_22108803_ChIP-Seq_LS180_Human1.36778557
67PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35821468
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35422067
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35165175
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34278972
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.33714172
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33074692
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32996863
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32780341
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32021188
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31651984
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31392199
78TCF4_23295773_ChIP-Seq_U87_Human1.31384824
79KDM2B_26808549_Chip-Seq_K562_Human1.30835807
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.29964372
81* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29171200
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27759071
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26640509
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25389940
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.24830364
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.24660272
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.24619808
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24492946
89SMAD4_21799915_ChIP-Seq_A2780_Human1.24395106
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24247700
91* CJUN_26792858_Chip-Seq_BT549_Human1.23429189
92STAT3_23295773_ChIP-Seq_U87_Human1.23354847
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.22831819
94CBP_20019798_ChIP-Seq_JUKART_Human1.22632970
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22632970
96POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21542245
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21395773
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.20716995
99LXR_22292898_ChIP-Seq_THP-1_Human1.20697391
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20423931
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20112947
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19566895
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19566895
104* TCF4_22108803_ChIP-Seq_LS180_Human1.17511052
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.17192782
106CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17084925
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16120260
108DROSHA_22980978_ChIP-Seq_HELA_Human1.15886715
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.15648438
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.15589742
111* ER_23166858_ChIP-Seq_MCF-7_Human1.14843293
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14597169
113* RUNX2_22187159_ChIP-Seq_PCA_Human1.14458870
114AR_25329375_ChIP-Seq_VCAP_Human1.14150116
115EWS_26573619_Chip-Seq_HEK293_Human1.13998717
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13993256
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13803923
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13436695
119KDM2B_26808549_Chip-Seq_DND41_Human1.13026320
120SOX2_20726797_ChIP-Seq_SW620_Human1.12791162
121FOXA2_19822575_ChIP-Seq_HepG2_Human1.12526767
122JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11988011
123NANOG_19829295_ChIP-Seq_ESCs_Human1.11944681
124SOX2_19829295_ChIP-Seq_ESCs_Human1.11944681
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11497273
126CDX2_20551321_ChIP-Seq_CACO-2_Human1.11267838
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.11233567
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10877058
129* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09547815
130HOXB7_26014856_ChIP-Seq_BT474_Human1.09283912
131CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08339769
132MYC_19829295_ChIP-Seq_ESCs_Human1.08325185
133KDM2B_26808549_Chip-Seq_REH_Human1.08317057
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07933885
135SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07933885
136CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07474404
137RNF2_27304074_Chip-Seq_ESCs_Mouse1.06749331
138* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05978878
139MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05696821
140SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05477403
141IRF1_19129219_ChIP-ChIP_H3396_Human1.05448570
142SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05040607
143SMAD4_21741376_ChIP-Seq_EPCs_Human1.04735286
144* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04378521
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04157075
146FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03985738
147FOXA1_25329375_ChIP-Seq_VCAP_Human1.03985738
148BP1_19119308_ChIP-ChIP_Hs578T_Human1.03576836
149NOTCH1_21737748_ChIP-Seq_TLL_Human1.03182480
150TP53_22573176_ChIP-Seq_HFKS_Human1.02614482
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01946562
152P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01718291
153ERA_21632823_ChIP-Seq_H3396_Human1.01709420
154TAF2_19829295_ChIP-Seq_ESCs_Human1.01651767
155CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01091306
156CDX2_22108803_ChIP-Seq_LS180_Human1.00317234
157TP53_16413492_ChIP-PET_HCT116_Human0.99940454
158ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99910082
159P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99267446
160ISL1_27105846_Chip-Seq_CPCs_Mouse0.98310197
161FOXH1_21741376_ChIP-Seq_ESCs_Human0.97983987
162CRX_20693478_ChIP-Seq_RETINA_Mouse0.97609543
163SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97090327
164SMAD3_21741376_ChIP-Seq_ESCs_Human0.96987033
165* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96541830
166KLF5_25053715_ChIP-Seq_YYC3_Human0.96451678
167CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96135129
168GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96112538
169KDM2B_26808549_Chip-Seq_JURKAT_Human0.95996435
170SMAD4_21741376_ChIP-Seq_HESCs_Human0.95837051
171AR_20517297_ChIP-Seq_VCAP_Human0.95788779
172* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95422069
173TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95403712
174BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94565522
175TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94416742
176* REST_21632747_ChIP-Seq_MESCs_Mouse0.94352440
177SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93455172
178EZH2_27294783_Chip-Seq_ESCs_Mouse0.92824488
179SMAD3_21741376_ChIP-Seq_HESCs_Human0.92582384
180DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91107750
181EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91053295
182DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90615079
183FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90054304
184BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88843343
185KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87993113
186* UBF1/2_26484160_Chip-Seq_HMECs_Human0.87813710
187SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86170375
188TP63_22573176_ChIP-Seq_HFKS_Human0.83995471
189* ATF3_27146783_Chip-Seq_COLON_Human0.83744643
190SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.82490235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.72004423
2MP0002254_reproductive_system_inflammat4.37518191
3MP0010234_abnormal_vibrissa_follicle3.70046220
4MP0005167_abnormal_blood-brain_barrier3.58099349
5MP0000750_abnormal_muscle_regeneration3.57471658
6MP0004036_abnormal_muscle_relaxation3.41258335
7MP0004272_abnormal_basement_membrane3.10003725
8MP0002138_abnormal_hepatobiliary_system2.96409881
9MP0001849_ear_inflammation2.94259325
10MP0005275_abnormal_skin_tensile2.77685614
11MP0001873_stomach_inflammation2.66777895
12MP0002837_dystrophic_cardiac_calcinosis2.64316520
13MP0002876_abnormal_thyroid_physiology2.55107758
14MP0003136_yellow_coat_color2.51870192
15MP0005330_cardiomyopathy2.46731237
16MP0003705_abnormal_hypodermis_morpholog2.46614587
17MP0008438_abnormal_cutaneous_collagen2.46491095
18MP0001501_abnormal_sleep_pattern2.44174223
19MP0003566_abnormal_cell_adhesion2.37039636
20MP0004043_abnormal_pH_regulation2.32170514
21MP0000751_myopathy2.31146672
22MP0002909_abnormal_adrenal_gland2.19272975
23MP0008875_abnormal_xenobiotic_pharmacok2.19209616
24MP0005551_abnormal_eye_electrophysiolog2.11830125
25MP0002933_joint_inflammation1.99664308
26MP0003300_gastrointestinal_ulcer1.96451455
27MP0008872_abnormal_physiological_respon1.92924165
28MP0000569_abnormal_digit_pigmentation1.91035446
29MP0003724_increased_susceptibility_to1.89656063
30MP0002234_abnormal_pharynx_morphology1.89606169
31MP0003045_fibrosis1.82552468
32MP0004019_abnormal_vitamin_homeostasis1.82439912
33MP0002108_abnormal_muscle_morphology1.78329101
34MP0004215_abnormal_myocardial_fiber1.76870852
35MP0005360_urolithiasis1.75537437
36MP0001984_abnormal_olfaction1.74957154
37MP0003137_abnormal_impulse_conducting1.74161627
38MP0005387_immune_system_phenotype1.72633039
39MP0001790_abnormal_immune_system1.72633039
40MP0010630_abnormal_cardiac_muscle1.71900116
41MP0005174_abnormal_tail_pigmentation1.70968538
42MP0001881_abnormal_mammary_gland1.70917592
43MP0002060_abnormal_skin_morphology1.70579478
44MP0010386_abnormal_urinary_bladder1.69415531
45MP0002972_abnormal_cardiac_muscle1.68535115
46MP0004087_abnormal_muscle_fiber1.68038907
47MP0000685_abnormal_immune_system1.67516622
48MP0004885_abnormal_endolymph1.67483802
49MP0002638_abnormal_pupillary_reflex1.62198676
50MP0001485_abnormal_pinna_reflex1.60979290
51MP0001270_distended_abdomen1.59025111
52MP0005623_abnormal_meninges_morphology1.58043603
53MP0005671_abnormal_response_to1.56851974
54MP0000762_abnormal_tongue_morphology1.51629991
55MP0005385_cardiovascular_system_phenoty1.48621345
56MP0001544_abnormal_cardiovascular_syste1.48621345
57MP0000858_altered_metastatic_potential1.47952444
58MP0002751_abnormal_autonomic_nervous1.45194025
59MP0000566_synostosis1.43832169
60MP0009785_altered_susceptibility_to1.42428081
61MP0000003_abnormal_adipose_tissue1.40876133
62MP0010678_abnormal_skin_adnexa1.39723403
63MP0003878_abnormal_ear_physiology1.39344859
64MP0005377_hearing/vestibular/ear_phenot1.39344859
65MP0005253_abnormal_eye_physiology1.38598700
66MP0002106_abnormal_muscle_physiology1.37299060
67MP0000579_abnormal_nail_morphology1.37012494
68MP0005620_abnormal_muscle_contractility1.33818139
69MP0004130_abnormal_muscle_cell1.33313761
70MP0002796_impaired_skin_barrier1.32320932
71MP0000230_abnormal_systemic_arterial1.31907173
72MP0004085_abnormal_heartbeat1.30534026
73MP0005332_abnormal_amino_acid1.29241125
74MP0000627_abnormal_mammary_gland1.28772384
75MP0002653_abnormal_ependyma_morphology1.28748417
76MP0005375_adipose_tissue_phenotype1.28210351
77MP0008877_abnormal_DNA_methylation1.27488786
78MP0003279_aneurysm1.26127557
79MP0003646_muscle_fatigue1.25619409
80MP0004147_increased_porphyrin_level1.25495006
81MP0006072_abnormal_retinal_apoptosis1.25321844
82MP0002896_abnormal_bone_mineralization1.24927081
83MP0000467_abnormal_esophagus_morphology1.23886240
84MP0010155_abnormal_intestine_physiology1.18779359
85MP0003011_delayed_dark_adaptation1.18456532
86MP0008775_abnormal_heart_ventricle1.18395923
87MP0001756_abnormal_urination1.18246953
88MP0009764_decreased_sensitivity_to1.17761637
89MP0006138_congestive_heart_failure1.17492672
90MP0002877_abnormal_melanocyte_morpholog1.16825685
91MP0004484_altered_response_of1.16313135
92MP0001986_abnormal_taste_sensitivity1.15923009
93MP0001502_abnormal_circadian_rhythm1.15631012
94MP0002282_abnormal_trachea_morphology1.15302219
95MP0005595_abnormal_vascular_smooth1.14981245
96MP0003935_abnormal_craniofacial_develop1.13723963
97MP0005369_muscle_phenotype1.13378408
98MP0004858_abnormal_nervous_system1.13156950
99MP0001663_abnormal_digestive_system1.12555056
100MP0005248_abnormal_Harderian_gland1.12462604
101MP0005666_abnormal_adipose_tissue1.10817026
102MP0002938_white_spotting1.10768432
103MP0002148_abnormal_hypersensitivity_rea1.09941780
104MP0009384_cardiac_valve_regurgitation1.08018359
105MP0003453_abnormal_keratinocyte_physiol1.07497110
106MP0005448_abnormal_energy_balance1.06609670
107MP0001800_abnormal_humoral_immune1.06224459
108MP0005365_abnormal_bile_salt1.04038779
109MP0000026_abnormal_inner_ear1.03892742
110MP0005647_abnormal_sex_gland1.03023262
111MP0000432_abnormal_head_morphology1.02371092
112MP0009840_abnormal_foam_cell1.01801066
113MP0001664_abnormal_digestion1.01714875
114MP0003436_decreased_susceptibility_to1.00585215
115MP0005171_absent_coat_pigmentation1.00140891
116MP0001968_abnormal_touch/_nociception0.99174094
117MP0001533_abnormal_skeleton_physiology0.98805399
118MP0002272_abnormal_nervous_system0.98433894
119MP0005023_abnormal_wound_healing0.98327422
120MP0003879_abnormal_hair_cell0.97928469
121MP0010329_abnormal_lipoprotein_level0.95544588
122MP0002136_abnormal_kidney_physiology0.94892221
123MP0000427_abnormal_hair_cycle0.94683755
124MP0005646_abnormal_pituitary_gland0.92504212
125MP0002098_abnormal_vibrissa_morphology0.92132512
126MP0000733_abnormal_muscle_development0.92074902
127MP0000604_amyloidosis0.91930579
128MP0003632_abnormal_nervous_system0.91325045
129MP0003690_abnormal_glial_cell0.91261644
130MP0010368_abnormal_lymphatic_system0.90337999
131MP0000462_abnormal_digestive_system0.90162670
132MP0009643_abnormal_urine_homeostasis0.90096088
133MP0001486_abnormal_startle_reflex0.89220249
134MP0005670_abnormal_white_adipose0.89068751
135MP0004185_abnormal_adipocyte_glucose0.88930593
136MP0005386_behavior/neurological_phenoty0.88043505
137MP0004924_abnormal_behavior0.88043505
138MP0000013_abnormal_adipose_tissue0.87808202
139MP0003195_calcinosis0.86903479
140MP0009745_abnormal_behavioral_response0.86091961
141MP0004133_heterotaxia0.86023527
142MP0009046_muscle_twitch0.85744865
143MP0000759_abnormal_skeletal_muscle0.85320093
144MP0000538_abnormal_urinary_bladder0.83142503
145MP0001188_hyperpigmentation0.82913604
146MP0000749_muscle_degeneration0.82358186
147MP0005085_abnormal_gallbladder_physiolo0.81066954
148MP0005381_digestive/alimentary_phenotyp0.80839823
149MP0000383_abnormal_hair_follicle0.80741705
150MP0001879_abnormal_lymphatic_vessel0.80447204
151MP0004510_myositis0.80110904
152MP0005195_abnormal_posterior_eye0.79526921
153MP0009780_abnormal_chondrocyte_physiolo0.79418149
154MP0002736_abnormal_nociception_after0.79402669
155MP0002095_abnormal_skin_pigmentation0.79126259
156MP0003828_pulmonary_edema0.78638188
157MP0004782_abnormal_surfactant_physiolog0.78308512
158MP0002277_abnormal_respiratory_mucosa0.78271903
159MP0002102_abnormal_ear_morphology0.78044800
160MP0000465_gastrointestinal_hemorrhage0.77758924
161MP0003329_amyloid_beta_deposits0.77656733
162MP0008995_early_reproductive_senescence0.77132231
163MP0002925_abnormal_cardiovascular_devel0.76644232
164MP0006054_spinal_hemorrhage0.76609485
165MP0000767_abnormal_smooth_muscle0.76014847
166MP0002269_muscular_atrophy0.75872157
167MP0003567_abnormal_fetal_cardiomyocyte0.74032830
168MP0005165_increased_susceptibility_to0.73569660
169MP0003638_abnormal_response/metabolism_0.72868367
170MP0010771_integument_phenotype0.71490050
171MP0003091_abnormal_cell_migration0.70281745
172MP0002128_abnormal_blood_circulation0.69445739
173MP0005501_abnormal_skin_physiology0.67544354
174MP0001216_abnormal_epidermal_layer0.67356318
175MP0002168_other_aberrant_phenotype0.66801458
176MP0005187_abnormal_penis_morphology0.65972452
177MP0000266_abnormal_heart_morphology0.64439782
178MP0001958_emphysema0.63083336
179MP0000534_abnormal_ureter_morphology0.61319410
180MP0010352_gastrointestinal_tract_polyps0.61112915

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.36232167
2Milia (HP:0001056)7.05790355
3Atrophic scars (HP:0001075)7.00519841
4Stomach cancer (HP:0012126)6.26846960
5Ependymoma (HP:0002888)6.25702405
6Right ventricular cardiomyopathy (HP:0011663)6.07353415
7Fragile nails (HP:0001808)5.40511739
8Astrocytoma (HP:0009592)4.77586859
9Abnormality of the astrocytes (HP:0100707)4.77586859
10Broad metatarsal (HP:0001783)4.19959870
11Ventricular tachycardia (HP:0004756)3.87794965
12Sudden death (HP:0001699)3.82901274
13Alveolar cell carcinoma (HP:0006519)3.60103089
14Glioma (HP:0009733)3.57024375
15Congenital stationary night blindness (HP:0007642)3.56857520
16Shallow orbits (HP:0000586)3.43842424
17Pancreatic cysts (HP:0001737)3.43040422
18Clumsiness (HP:0002312)3.32155845
19Neoplasm of the tracheobronchial system (HP:0100552)3.30771623
20Type II lissencephaly (HP:0007260)3.29163935
21Tubular atrophy (HP:0000092)3.28868039
22Plantar hyperkeratosis (HP:0007556)3.19022946
23Decreased circulating renin level (HP:0003351)3.18662392
24Abnormality of the renal cortex (HP:0011035)3.15374123
25Birth length less than 3rd percentile (HP:0003561)3.11025505
26Autoimmune thrombocytopenia (HP:0001973)3.07328487
27Abnormality of the renal medulla (HP:0100957)3.07271467
28Hyperventilation (HP:0002883)3.06689404
29Cerebral aneurysm (HP:0004944)3.05764963
30Abnormality of midbrain morphology (HP:0002418)3.05701111
31Molar tooth sign on MRI (HP:0002419)3.05701111
32Nephronophthisis (HP:0000090)3.01760024
33Fragile skin (HP:0001030)2.99846576
34Aplasia cutis congenita (HP:0001057)2.97417765
35Increased connective tissue (HP:0009025)2.95815710
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.91476467
37Hypoplasia of dental enamel (HP:0006297)2.91118096
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.88016446
39Protruding tongue (HP:0010808)2.85768535
40Pancreatic fibrosis (HP:0100732)2.81828477
41Hyporeflexia of lower limbs (HP:0002600)2.81147969
42Premature rupture of membranes (HP:0001788)2.78809041
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.77604963
44Attenuation of retinal blood vessels (HP:0007843)2.76679993
45Renal tubular acidosis (HP:0001947)2.76231933
46Anterior segment dysgenesis (HP:0007700)2.76124761
47Turricephaly (HP:0000262)2.74323008
48Cerebellar dysplasia (HP:0007033)2.66260113
49Duplicated collecting system (HP:0000081)2.62178230
50Ankle contracture (HP:0006466)2.60659586
51Metabolic alkalosis (HP:0200114)2.58992126
52Abnormal drinking behavior (HP:0030082)2.56547381
53Polydipsia (HP:0001959)2.56547381
54Bronchomalacia (HP:0002780)2.56290879
55Nail dystrophy (HP:0008404)2.56227502
56Pili torti (HP:0003777)2.55074207
57Pendular nystagmus (HP:0012043)2.53768235
58Abolished electroretinogram (ERG) (HP:0000550)2.53317454
59Abnormality of the renal collecting system (HP:0004742)2.52293871
60Enlarged penis (HP:0000040)2.51596464
61Inability to walk (HP:0002540)2.50142514
62True hermaphroditism (HP:0010459)2.50133466
63Hypoplasia of the iris (HP:0007676)2.48102541
64Muscle fiber splitting (HP:0003555)2.42646389
65Increased cerebral lipofuscin (HP:0011813)2.38939187
66Mesangial abnormality (HP:0001966)2.38517123
67Abnormality of renin-angiotensin system (HP:0000847)2.37579153
68Abnormal rod and cone electroretinograms (HP:0008323)2.36839140
69Polyuria (HP:0000103)2.34485346
70Thyroid-stimulating hormone excess (HP:0002925)2.32234548
71Adactyly (HP:0009776)2.32100108
72Syncope (HP:0001279)2.30448908
73Rib fusion (HP:0000902)2.29806991
74Abnormality of glutamine family amino acid metabolism (HP:0010902)2.27647657
75Atrial fibrillation (HP:0005110)2.27501219
76Exercise-induced muscle cramps (HP:0003710)2.25304058
77Hematochezia (HP:0002573)2.24486190
78Ventricular arrhythmia (HP:0004308)2.24144161
79Aneurysm (HP:0002617)2.23193470
80Hemorrhage of the eye (HP:0011885)2.23072058
81Congenital, generalized hypertrichosis (HP:0004540)2.23062298
82Abnormal blistering of the skin (HP:0008066)2.21356550
83Aortic dissection (HP:0002647)2.21208380
84Cystic liver disease (HP:0006706)2.21055329
85Broad-based gait (HP:0002136)2.20467937
86Large for gestational age (HP:0001520)2.19570395
87Recurrent cutaneous fungal infections (HP:0011370)2.19100203
88Chronic mucocutaneous candidiasis (HP:0002728)2.19100203
89Complement deficiency (HP:0004431)2.18453773
90Lipoatrophy (HP:0100578)2.15655700
91Potter facies (HP:0002009)2.14965059
92Facial shape deformation (HP:0011334)2.14965059
93Hypoalbuminemia (HP:0003073)2.13016172
94Abnormal albumin level (HP:0012116)2.13016172
95Congenital sensorineural hearing impairment (HP:0008527)2.12395644
96Chorioretinal atrophy (HP:0000533)2.11843474
97Protrusio acetabuli (HP:0003179)2.11328858
98Primary atrial arrhythmia (HP:0001692)2.07178159
99Enlarged epiphyses (HP:0010580)2.06265774
100Progressive inability to walk (HP:0002505)2.05699123
101Increased corneal curvature (HP:0100692)2.05165382
102Keratoconus (HP:0000563)2.05165382
103Neoplasm of the lung (HP:0100526)2.04458389
104Glomerulonephritis (HP:0000099)2.03808005
105Hyperglycinuria (HP:0003108)2.03145565
106Abnormal urine output (HP:0012590)2.02932269
107Abnormality of proline metabolism (HP:0010907)2.02868095
108Hydroxyprolinuria (HP:0003080)2.02868095
109Tubulointerstitial fibrosis (HP:0005576)2.02260488
110Ventricular fibrillation (HP:0001663)2.00837059
111Supraventricular arrhythmia (HP:0005115)2.00755261
112Amelogenesis imperfecta (HP:0000705)10.8239930
113Congenital hepatic fibrosis (HP:0002612)1.99142762
114Gaze-evoked nystagmus (HP:0000640)1.98269868
115Bundle branch block (HP:0011710)1.97521408
116Arterial tortuosity (HP:0005116)1.96841610
117Hypomagnesemia (HP:0002917)1.96606245
118Renal cortical cysts (HP:0000803)1.96191613
119Short hallux (HP:0010109)1.95602975
120Autoimmune hemolytic anemia (HP:0001890)1.94258385
121Supraventricular tachycardia (HP:0004755)1.93289917
122Conical tooth (HP:0000698)1.92214330
123Difficulty running (HP:0009046)1.90180990
124Palpitations (HP:0001962)1.89635991
125Hypoplastic ischia (HP:0003175)1.89574690
126Alkalosis (HP:0001948)1.89544472
127Myoglobinuria (HP:0002913)1.89380524
128Anosmia (HP:0000458)1.88610453
129Medial flaring of the eyebrow (HP:0010747)1.88472169
130Mildly elevated creatine phosphokinase (HP:0008180)1.87363457
131Absent speech (HP:0001344)1.87095937
132Exercise-induced myalgia (HP:0003738)1.86999717
133Widely spaced teeth (HP:0000687)1.84532724
134Clubbing of toes (HP:0100760)1.83977288
135Systemic lupus erythematosus (HP:0002725)1.83556067
136Hypokalemic alkalosis (HP:0001949)1.83250725
137Calf muscle hypertrophy (HP:0008981)1.82513276
138Abnormality of the calf musculature (HP:0001430)1.82108668
139Aortic aneurysm (HP:0004942)1.81934087
140Hypothermia (HP:0002045)1.81489015
141Keratoconjunctivitis (HP:0001096)1.80321059
142Subaortic stenosis (HP:0001682)1.80213489
143Abnormality of the left ventricular outflow tract (HP:0011103)1.80213489
144Type 1 muscle fiber predominance (HP:0003803)1.76176801
145Vascular tortuosity (HP:0004948)1.75696487
146Aplasia/Hypoplasia of the hallux (HP:0008362)1.75049663
147Abnormality of macular pigmentation (HP:0008002)1.74863416
148Difficulty climbing stairs (HP:0003551)1.74540918
149Abnormality of renal excretion (HP:0011036)1.74451383
150Increased variability in muscle fiber diameter (HP:0003557)1.74203403
151Prolonged QT interval (HP:0001657)1.73506614
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73197600
153Urethral obstruction (HP:0000796)1.72874813
154Aplasia/Hypoplasia of the tibia (HP:0005772)1.71760348
155Focal segmental glomerulosclerosis (HP:0000097)1.71213372
156Preaxial foot polydactyly (HP:0001841)1.70119139
157Abnormal biliary tract physiology (HP:0012439)1.70009163
158Bile duct proliferation (HP:0001408)1.70009163
159Morphological abnormality of the inner ear (HP:0011390)1.68983594
160Neoplasm of the respiratory system (HP:0100606)1.68795497
161Pigmentary retinal degeneration (HP:0001146)1.68430368
162EMG: myopathic abnormalities (HP:0003458)1.68160445
163Asymmetric septal hypertrophy (HP:0001670)1.67797788
164Hemoptysis (HP:0002105)1.67738725
165Optic nerve hypoplasia (HP:0000609)1.67391881
166Dilated cardiomyopathy (HP:0001644)1.66983408
167Abnormality of the anterior chamber (HP:0000593)1.66617361
168Ectopic kidney (HP:0000086)1.65641297
169Metaphyseal cupping (HP:0003021)1.65205428
170Blue sclerae (HP:0000592)1.65121739
171Fair hair (HP:0002286)1.64816055
172Bladder diverticulum (HP:0000015)1.64341335
173Abnormality of the ischium (HP:0003174)1.64193513
174Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63740018
175Cardiovascular calcification (HP:0011915)1.63479046
176Decreased central vision (HP:0007663)1.63239571
177Lymphangioma (HP:0100764)1.62723805
178Distal lower limb amyotrophy (HP:0008944)1.62332964
179Abnormality of the 4th metacarpal (HP:0010012)1.62156498
180Atrioventricular block (HP:0001678)1.61766890
181Enlarged kidneys (HP:0000105)1.61732520
182Non-midline cleft lip (HP:0100335)1.61321970
183Coronal craniosynostosis (HP:0004440)1.60787450
184Malnutrition (HP:0004395)1.60530054
185Sudden cardiac death (HP:0001645)1.58431565
186Abnormal atrioventricular conduction (HP:0005150)1.57827400
187Pterygium (HP:0001059)1.55610094
188Scapular winging (HP:0003691)1.52549345
189Vascular calcification (HP:0004934)1.52436565
190Mitral valve prolapse (HP:0001634)1.52171817
191Woolly hair (HP:0002224)1.51891967
192Heart block (HP:0012722)1.51656796
193Abnormal hair laboratory examination (HP:0003328)1.50810646
194Muscle hypertrophy of the lower extremities (HP:0008968)1.50027662
195Neuroepithelial neoplasm (HP:0030063)1.49847919
196Nervous tissue neoplasm (HP:0030060)1.49847919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MATK7.70984996
2FRK4.87798446
3EPHA24.42008317
4ACVR1B4.00048896
5SIK13.91715179
6TLK13.68954946
7BMPR1B3.52398220
8ADRBK23.12342142
9GRK12.56957546
10INSRR2.55956801
11TTN2.53883089
12WNK42.51712831
13PKN22.46406341
14EPHB12.45056921
15TRIB32.38708489
16ERBB22.31455403
17OXSR12.29358400
18PINK12.24590885
19TGFBR12.24133442
20NME22.23560338
21EPHA32.16405733
22FER2.15146702
23WNK32.14202892
24RIPK12.08049766
25EPHA42.01860122
26LATS11.99680831
27LMTK21.89272609
28BMX1.78671858
29TXK1.78305923
30KIT1.77577519
31STK391.75294793
32ZAK1.60727414
33ERN11.59802334
34FGFR41.43678958
35PIK3CA1.43080407
36TIE11.38890562
37MAP4K21.38484362
38PDK41.38256467
39PDK31.38256467
40PDGFRA1.37068436
41PTK61.31013001
42MAP2K61.28402782
43TGFBR21.28254548
44MAP3K31.26523434
45NUAK11.22603292
46CAMK1G1.21447771
47RET1.18423781
48PDK21.10965725
49NTRK31.10324225
50DMPK1.09940186
51PAK31.07466554
52MYLK1.03752790
53TAOK31.02395469
54PTK21.00017791
55MARK30.99222953
56FGFR10.99123412
57NME10.98273354
58EPHB20.95212553
59ADRBK10.94966291
60KDR0.94325484
61WNK10.93079858
62TRPM70.92790863
63MAP3K40.92063692
64CAMK1D0.91688492
65MAPK130.91392203
66LRRK20.87079581
67IKBKB0.84816714
68MAP3K70.82939116
69PRKD10.82743491
70MAP3K20.81416747
71LATS20.81031027
72EEF2K0.80917739
73CAMK40.79301195
74STK380.78257433
75TNIK0.78143642
76DYRK1B0.76522215
77CASK0.76275691
78PAK40.75747176
79PHKG10.73524000
80PHKG20.73524000
81MKNK20.73520669
82NTRK10.73029951
83CAMK10.72131276
84BCKDK0.70126609
85CAMKK20.68645329
86CHUK0.67874247
87FGFR30.67245122
88MAPK150.67041593
89NEK20.65983759
90SGK2230.65384480
91SGK4940.65384480
92CDK60.64139980
93RPS6KA60.62880841
94PRKCG0.61095523
95IRAK10.61023586
96TYK20.60458154
97MET0.60193216
98PAK20.58623168
99EGFR0.57214012
100STK110.56165845
101SGK20.55474818
102PTK2B0.55439292
103TEC0.53594824
104MAPK70.52463671
105CSNK1A1L0.52315290
106CAMK2A0.52165782
107MAP3K10.51764628
108BLK0.51119536
109CSNK1G10.50327181
110DAPK20.50279809
111IGF1R0.49787631
112PDGFRB0.49765215
113MAPKAPK50.49255471
114DYRK20.48588780
115ICK0.48582748
116PRKD30.48570401
117JAK30.47731860
118PRKCE0.47637396
119IKBKE0.47050274
120GRK70.45387352
121PRKCH0.45287679
122PKN10.45268424
123CDK190.45236920
124JAK10.43540563
125CSNK1A10.42052020
126FLT30.41773658
127CDK30.41594754
128PRKAA10.40782151
129MAP3K100.40262858
130MAP4K10.40016599
131PRKCQ0.39714953
132TNK20.39706901
133DDR20.39635987
134OBSCN0.39208296
135ALK0.39078195
136NLK0.39072029
137ROCK10.38063810
138MELK0.37945820
139MTOR0.36852039
140GSK3A0.36479583
141CDC42BPA0.36424317
142NEK10.36166572
143KSR20.35914559
144STK30.35852313
145CSNK1G30.35105026
146TAOK10.34636021
147CSNK1G20.33123634
148PRKG20.32211626
149PDPK10.31695610
150FGFR20.30680515
151CSNK1D0.30144584
152MAP3K60.29912839
153LCK0.29834832
154MST1R0.29716432
155SRC0.28536134
156STK38L0.28071621
157PRKCZ0.28010057
158TESK10.27900507
159MAPK120.27423067
160ROCK20.26972454
161DAPK30.26730141
162MST40.26312574
163MAP2K10.26246006
164PRKAA20.25461011
165TYRO30.24771796
166PDK10.24640686
167JAK20.23611837
168MAPKAPK30.22746317

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.18295364
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.12965083
3Linoleic acid metabolism_Homo sapiens_hsa005913.02299093
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.66713640
5Adherens junction_Homo sapiens_hsa045202.48331618
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.35911724
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.35549774
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.33629975
9Dilated cardiomyopathy_Homo sapiens_hsa054142.28086813
10Bladder cancer_Homo sapiens_hsa052192.24818164
11Focal adhesion_Homo sapiens_hsa045102.23301920
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.21577516
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17304003
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.15445284
15Ether lipid metabolism_Homo sapiens_hsa005652.14708527
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.14529912
17Asthma_Homo sapiens_hsa053102.08126495
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06556035
19Autoimmune thyroid disease_Homo sapiens_hsa053201.98382438
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.95868850
21Amoebiasis_Homo sapiens_hsa051461.95423002
22Allograft rejection_Homo sapiens_hsa053301.92791592
23Collecting duct acid secretion_Homo sapiens_hsa049661.92542688
24Graft-versus-host disease_Homo sapiens_hsa053321.90717821
25Histidine metabolism_Homo sapiens_hsa003401.81491530
26Fatty acid degradation_Homo sapiens_hsa000711.81062659
27Phototransduction_Homo sapiens_hsa047441.76452195
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75592382
29Endometrial cancer_Homo sapiens_hsa052131.74543825
30Fatty acid biosynthesis_Homo sapiens_hsa000611.74337692
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72911271
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70144628
33Staphylococcus aureus infection_Homo sapiens_hsa051501.68428309
34Arachidonic acid metabolism_Homo sapiens_hsa005901.63555986
35Small cell lung cancer_Homo sapiens_hsa052221.63070825
36Pancreatic cancer_Homo sapiens_hsa052121.55800267
37Proteoglycans in cancer_Homo sapiens_hsa052051.54652057
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54456083
39Type I diabetes mellitus_Homo sapiens_hsa049401.53343235
40Selenocompound metabolism_Homo sapiens_hsa004501.52080547
41Non-small cell lung cancer_Homo sapiens_hsa052231.51470394
42HIF-1 signaling pathway_Homo sapiens_hsa040661.50021111
43Fatty acid metabolism_Homo sapiens_hsa012121.48926652
44PPAR signaling pathway_Homo sapiens_hsa033201.39981661
45Propanoate metabolism_Homo sapiens_hsa006401.34644348
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33347503
47Glycerolipid metabolism_Homo sapiens_hsa005611.28921062
48Fat digestion and absorption_Homo sapiens_hsa049751.27852183
49Vibrio cholerae infection_Homo sapiens_hsa051101.26978478
50Mineral absorption_Homo sapiens_hsa049781.25394131
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24548358
52Salivary secretion_Homo sapiens_hsa049701.24498002
53Ovarian steroidogenesis_Homo sapiens_hsa049131.22819762
54Retinol metabolism_Homo sapiens_hsa008301.20635690
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.18359308
56Insulin resistance_Homo sapiens_hsa049311.17991182
57Chemical carcinogenesis_Homo sapiens_hsa052041.17233660
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14019186
59Protein digestion and absorption_Homo sapiens_hsa049741.13228230
60Pyruvate metabolism_Homo sapiens_hsa006201.12514958
61Renal cell carcinoma_Homo sapiens_hsa052111.08156412
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08047597
63Vitamin digestion and absorption_Homo sapiens_hsa049771.07234909
64ABC transporters_Homo sapiens_hsa020101.06777635
65Maturity onset diabetes of the young_Homo sapiens_hsa049501.06767881
66Toxoplasmosis_Homo sapiens_hsa051451.06586164
67Vascular smooth muscle contraction_Homo sapiens_hsa042701.03050171
68Prostate cancer_Homo sapiens_hsa052151.01629040
69African trypanosomiasis_Homo sapiens_hsa051431.00825774
70Tight junction_Homo sapiens_hsa045301.00571815
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00046266
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.97105716
73Arginine biosynthesis_Homo sapiens_hsa002200.96743466
74Carbon metabolism_Homo sapiens_hsa012000.94677581
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93303066
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93251824
77ErbB signaling pathway_Homo sapiens_hsa040120.93090195
78Lysine degradation_Homo sapiens_hsa003100.92544512
79Caffeine metabolism_Homo sapiens_hsa002320.91057087
80Olfactory transduction_Homo sapiens_hsa047400.89967405
81Viral myocarditis_Homo sapiens_hsa054160.89255477
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87809807
83Taste transduction_Homo sapiens_hsa047420.87578284
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.86655720
85Cardiac muscle contraction_Homo sapiens_hsa042600.86604198
86Bile secretion_Homo sapiens_hsa049760.86334974
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86206369
88Basal cell carcinoma_Homo sapiens_hsa052170.86122616
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85273167
90MicroRNAs in cancer_Homo sapiens_hsa052060.84238207
91Dorso-ventral axis formation_Homo sapiens_hsa043200.83262029
92Pathways in cancer_Homo sapiens_hsa052000.82670857
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.80862593
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80072361
95Notch signaling pathway_Homo sapiens_hsa043300.78285064
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77963232
97Gastric acid secretion_Homo sapiens_hsa049710.77657509
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77300727
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76821826
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76745094
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76116782
102Nitrogen metabolism_Homo sapiens_hsa009100.74721089
103Chronic myeloid leukemia_Homo sapiens_hsa052200.73008630
104Hippo signaling pathway_Homo sapiens_hsa043900.71455452
105Phenylalanine metabolism_Homo sapiens_hsa003600.70262112
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70195252
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70098970
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.69789646
109Complement and coagulation cascades_Homo sapiens_hsa046100.69749843
110Glucagon signaling pathway_Homo sapiens_hsa049220.68899053
111Renin-angiotensin system_Homo sapiens_hsa046140.68886154
112Tryptophan metabolism_Homo sapiens_hsa003800.68635826
113Nicotine addiction_Homo sapiens_hsa050330.68494115
114beta-Alanine metabolism_Homo sapiens_hsa004100.68045166
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.67347422
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66085645
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66007728
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.65959511
119Butanoate metabolism_Homo sapiens_hsa006500.65674707
120Homologous recombination_Homo sapiens_hsa034400.64872628
121Insulin signaling pathway_Homo sapiens_hsa049100.64661006
122Galactose metabolism_Homo sapiens_hsa000520.64319646
123AMPK signaling pathway_Homo sapiens_hsa041520.64189523
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63791133
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62952315
126Morphine addiction_Homo sapiens_hsa050320.59758691
127Starch and sucrose metabolism_Homo sapiens_hsa005000.59493554
128Renin secretion_Homo sapiens_hsa049240.59413662
129Axon guidance_Homo sapiens_hsa043600.57382192
130Melanogenesis_Homo sapiens_hsa049160.57306590
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56439234
132Estrogen signaling pathway_Homo sapiens_hsa049150.55623555
133Rap1 signaling pathway_Homo sapiens_hsa040150.54321541
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53527762
135Biosynthesis of amino acids_Homo sapiens_hsa012300.52910705
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52329272
137Calcium signaling pathway_Homo sapiens_hsa040200.52289016
138Rheumatoid arthritis_Homo sapiens_hsa053230.51970075
139Lysosome_Homo sapiens_hsa041420.51772968
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51196851
141Synaptic vesicle cycle_Homo sapiens_hsa047210.50400850
142Platelet activation_Homo sapiens_hsa046110.50012953
143Primary immunodeficiency_Homo sapiens_hsa053400.49956997
144Pertussis_Homo sapiens_hsa051330.49933585
145Glioma_Homo sapiens_hsa052140.49410267
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47968280
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47512582
148Type II diabetes mellitus_Homo sapiens_hsa049300.47445358
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47055215
150Serotonergic synapse_Homo sapiens_hsa047260.46850783
151Acute myeloid leukemia_Homo sapiens_hsa052210.46544498
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46144919
153Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46124301
154Peroxisome_Homo sapiens_hsa041460.45957820
155Insulin secretion_Homo sapiens_hsa049110.44037155
156Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43830906
157VEGF signaling pathway_Homo sapiens_hsa043700.43330790
158GnRH signaling pathway_Homo sapiens_hsa049120.43247166
159Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42232189
160Gap junction_Homo sapiens_hsa045400.41298548
161Oxidative phosphorylation_Homo sapiens_hsa001900.39353712
162TNF signaling pathway_Homo sapiens_hsa046680.38334401
163Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35770438
164Glutamatergic synapse_Homo sapiens_hsa047240.34052389
165cAMP signaling pathway_Homo sapiens_hsa040240.33970792
166Basal transcription factors_Homo sapiens_hsa030220.32980140
167GABAergic synapse_Homo sapiens_hsa047270.32655990
168Circadian entrainment_Homo sapiens_hsa047130.32478888
169Arginine and proline metabolism_Homo sapiens_hsa003300.32420584
170Hedgehog signaling pathway_Homo sapiens_hsa043400.31470758
171Jak-STAT signaling pathway_Homo sapiens_hsa046300.31352194

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