PAPOLG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)4.58107470
2neural tube formation (GO:0001841)4.24610387
3cell wall macromolecule metabolic process (GO:0044036)3.96907752
4regulation of cilium movement (GO:0003352)3.95537885
5monoubiquitinated protein deubiquitination (GO:0035520)3.63351062
6fucose catabolic process (GO:0019317)3.62612731
7L-fucose metabolic process (GO:0042354)3.62612731
8L-fucose catabolic process (GO:0042355)3.62612731
9kinetochore organization (GO:0051383)3.49691369
10histone H3-K4 trimethylation (GO:0080182)3.48720547
11protein K11-linked deubiquitination (GO:0035871)3.47482207
12kinetochore assembly (GO:0051382)3.45804544
13interferon-gamma production (GO:0032609)3.18562311
14prenylation (GO:0097354)3.14827395
15protein prenylation (GO:0018342)3.14827395
16microtubule anchoring (GO:0034453)3.13571537
17RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11681552
18cilium morphogenesis (GO:0060271)3.07593009
19detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03324647
20double-strand break repair via homologous recombination (GO:0000724)3.01054401
21recombinational repair (GO:0000725)3.00687064
22regulation of telomere maintenance (GO:0032204)3.00385038
23DNA strand renaturation (GO:0000733)2.99678487
24negative regulation of DNA-dependent DNA replication (GO:2000104)2.97237250
25regulation of hexokinase activity (GO:1903299)2.95803174
26regulation of glucokinase activity (GO:0033131)2.95803174
27histone H2A acetylation (GO:0043968)2.95080367
28pyrimidine nucleobase catabolic process (GO:0006208)2.94907388
29protein polyglutamylation (GO:0018095)2.93582104
30cell differentiation involved in metanephros development (GO:0072202)2.92272266
31microtubule depolymerization (GO:0007019)2.91537918
32indolalkylamine metabolic process (GO:0006586)2.90759990
33synapsis (GO:0007129)2.90620929
34behavioral response to nicotine (GO:0035095)2.89000337
35centriole replication (GO:0007099)2.87920383
36nonmotile primary cilium assembly (GO:0035058)2.87868734
37centriole assembly (GO:0098534)2.82238986
38platelet dense granule organization (GO:0060155)2.81234836
39limb bud formation (GO:0060174)2.81088153
40regulation of centriole replication (GO:0046599)2.78865605
41attachment of spindle microtubules to kinetochore (GO:0008608)2.77762313
42DNA demethylation (GO:0080111)2.77281800
43replication fork processing (GO:0031297)2.76477363
44superoxide anion generation (GO:0042554)2.73841750
45cilium organization (GO:0044782)2.72910796
46detection of light stimulus involved in sensory perception (GO:0050962)2.72361676
47detection of light stimulus involved in visual perception (GO:0050908)2.72361676
48photoreceptor cell maintenance (GO:0045494)2.71869929
49anterograde synaptic vesicle transport (GO:0048490)2.71305350
50cellular response to interleukin-15 (GO:0071350)2.70709556
51interkinetic nuclear migration (GO:0022027)2.70465112
52inositol phosphate catabolic process (GO:0071545)2.69841854
53establishment of protein localization to Golgi (GO:0072600)2.69673526
54cilium assembly (GO:0042384)2.69103790
55retinal cone cell development (GO:0046549)2.69066899
56ncRNA catabolic process (GO:0034661)2.68602196
57adaptation of signaling pathway (GO:0023058)2.65473012
58DNA methylation involved in gamete generation (GO:0043046)2.64515924
59polyol catabolic process (GO:0046174)2.64308574
60regulation of meiosis I (GO:0060631)2.63853344
61regulation of nuclear cell cycle DNA replication (GO:0033262)2.63717998
62intraciliary transport (GO:0042073)2.63072468
63negative regulation of telomere maintenance (GO:0032205)2.62288460
64protein K6-linked ubiquitination (GO:0085020)2.60838877
65germinal center formation (GO:0002467)2.57005128
66male meiosis (GO:0007140)2.56381661
67positive regulation of interleukin-1 beta secretion (GO:0050718)2.55386878
68mesenchymal cell differentiation involved in renal system development (GO:2001012)2.54016626
69mesenchymal cell differentiation involved in kidney development (GO:0072161)2.54016626
70resolution of meiotic recombination intermediates (GO:0000712)2.53579801
71nucleobase catabolic process (GO:0046113)2.53426838
72female gonad development (GO:0008585)2.53291031
73myelin assembly (GO:0032288)2.53163040
74mast cell activation (GO:0045576)2.52976164
75response to pheromone (GO:0019236)2.52444917
76lymphoid progenitor cell differentiation (GO:0002320)2.52242913
77reciprocal meiotic recombination (GO:0007131)2.51757948
78reciprocal DNA recombination (GO:0035825)2.51757948
79histone H3-K36 demethylation (GO:0070544)2.50533488
80histone mRNA catabolic process (GO:0071044)2.50095390
81protein-cofactor linkage (GO:0018065)2.49741244
82negative T cell selection (GO:0043383)2.49352284
83regulation of DNA endoreduplication (GO:0032875)2.48738860
84negative regulation of DNA recombination (GO:0045910)2.48682537
85dendritic cell migration (GO:0036336)2.47973392
86dendritic cell chemotaxis (GO:0002407)2.47494646
87retinal ganglion cell axon guidance (GO:0031290)2.46403342
88chromatin remodeling at centromere (GO:0031055)2.46287055
89water-soluble vitamin biosynthetic process (GO:0042364)2.45544902
90gene silencing by RNA (GO:0031047)2.45459177
91retinal rod cell development (GO:0046548)2.45285338
92reflex (GO:0060004)2.45242235
93photoreceptor cell development (GO:0042461)2.44984334
94acrosome assembly (GO:0001675)2.44935002
95regulation of MHC class II biosynthetic process (GO:0045346)2.44903141
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.44808975
97regulation of collateral sprouting (GO:0048670)2.43911963
98rRNA catabolic process (GO:0016075)2.43789710
99olfactory bulb development (GO:0021772)2.43693921
100regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.42796299
101regulation of microtubule-based movement (GO:0060632)2.41258265
102preassembly of GPI anchor in ER membrane (GO:0016254)2.41239961
103DNA ligation (GO:0006266)2.41155541
104lymph node development (GO:0048535)2.41066811
105positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.40666668
106somite rostral/caudal axis specification (GO:0032525)2.39766071
107protein targeting to Golgi (GO:0000042)2.39577174
108negative regulation of mast cell activation (GO:0033004)2.39513110
109phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.39206522
110regulation of timing of cell differentiation (GO:0048505)2.38584270
111regulation of sarcomere organization (GO:0060297)2.38268150
112cerebral cortex radially oriented cell migration (GO:0021799)2.38254018
113V(D)J recombination (GO:0033151)2.37857500
114nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.37806233
115phosphorylated carbohydrate dephosphorylation (GO:0046838)2.37068757
116inositol phosphate dephosphorylation (GO:0046855)2.37068757
117kynurenine metabolic process (GO:0070189)2.35655601
118somatic hypermutation of immunoglobulin genes (GO:0016446)2.35393628
119piRNA metabolic process (GO:0034587)2.33676101
120regulation of B cell receptor signaling pathway (GO:0050855)2.32251233
121DNA double-strand break processing (GO:0000729)2.31786212
122negative thymic T cell selection (GO:0045060)2.31275789
123B cell homeostasis (GO:0001782)2.31085123
124positive regulation of interleukin-1 secretion (GO:0050716)2.28790367
125histone H3-K4 methylation (GO:0051568)2.28391399
126regulation of interleukin-1 beta secretion (GO:0050706)2.27857301
127dentate gyrus development (GO:0021542)2.27663167
128presynaptic membrane assembly (GO:0097105)2.26590998
129negative regulation of execution phase of apoptosis (GO:1900118)2.26037022
130NIK/NF-kappaB signaling (GO:0038061)2.25866019
131meiotic chromosome segregation (GO:0045132)2.25660855
132positive regulation of alpha-beta T cell proliferation (GO:0046641)2.23556150
133regulation of germinal center formation (GO:0002634)2.22413085
134regulation of T cell tolerance induction (GO:0002664)2.21330275
135presynaptic membrane organization (GO:0097090)2.19641933
136negative regulation of T cell mediated immunity (GO:0002710)2.19349256
137alpha-beta T cell differentiation (GO:0046632)2.19111177
138regulation of T cell receptor signaling pathway (GO:0050856)2.18921392
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.18782524
140replicative senescence (GO:0090399)2.18536333
141T cell homeostasis (GO:0043029)2.17752896
142energy homeostasis (GO:0097009)2.17232597
143radial glial cell differentiation (GO:0060019)2.17037691
144mature B cell differentiation (GO:0002335)2.16847104
145DNA synthesis involved in DNA repair (GO:0000731)2.16465864
146alpha-beta T cell activation (GO:0046631)2.16369532
147negative regulation of translation, ncRNA-mediated (GO:0040033)2.16198116
148regulation of translation, ncRNA-mediated (GO:0045974)2.16198116
149negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.16198116
150positive regulation of interleukin-17 production (GO:0032740)2.14994640
151CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.13982757
152protein localization to cilium (GO:0061512)2.13438948
153response to X-ray (GO:0010165)2.13167098
154T cell migration (GO:0072678)2.13046260
155CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.12669556
156T-helper cell differentiation (GO:0042093)2.12669556
157positive regulation of granulocyte differentiation (GO:0030854)2.10650750
158regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.09987912
159regulation of mitotic spindle checkpoint (GO:1903504)2.09987912
160regulation of alpha-beta T cell proliferation (GO:0046640)2.09681935
161nuclear pore complex assembly (GO:0051292)2.09100312
162spinal cord motor neuron differentiation (GO:0021522)2.08522271
163retina layer formation (GO:0010842)2.08390503
164G-protein coupled receptor internalization (GO:0002031)2.08034714
165regulation of helicase activity (GO:0051095)2.06844826
166T cell differentiation (GO:0030217)2.06802737
167positive regulation of protein homodimerization activity (GO:0090073)2.05323105
168peptidyl-lysine trimethylation (GO:0018023)2.05091825
169inner ear receptor stereocilium organization (GO:0060122)2.04983462
170kidney morphogenesis (GO:0060993)2.04515437
171histamine secretion (GO:0001821)2.04444334
172positive regulation of interleukin-2 production (GO:0032743)2.04388005
173centrosome duplication (GO:0051298)2.03386272
174cell differentiation involved in kidney development (GO:0061005)2.03226664
175T cell selection (GO:0045058)2.02528670
176RNA destabilization (GO:0050779)2.02268828
177leukocyte aggregation (GO:0070486)2.02160861
178T cell differentiation involved in immune response (GO:0002292)2.02130046
179alpha-beta T cell differentiation involved in immune response (GO:0002293)2.02130046
180alpha-beta T cell activation involved in immune response (GO:0002287)2.02130046
181regulation of interleukin-2 biosynthetic process (GO:0045076)2.01717709
182spleen development (GO:0048536)2.00768865
183intra-S DNA damage checkpoint (GO:0031573)2.00345486
184regulation of development, heterochronic (GO:0040034)1.99825678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.18916559
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.49838813
3ZNF274_21170338_ChIP-Seq_K562_Hela3.47543305
4GBX2_23144817_ChIP-Seq_PC3_Human3.16910636
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67081576
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.60101285
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.59569494
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51954925
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36246685
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33851894
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.31413805
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.25074457
13TAF15_26573619_Chip-Seq_HEK293_Human2.18942959
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.17432428
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.13032951
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09088173
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05932288
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.01526165
19IGF1R_20145208_ChIP-Seq_DFB_Human1.99410733
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98705310
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96498333
22TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.95375701
23EWS_26573619_Chip-Seq_HEK293_Human1.94803803
24NANOG_18555785_Chip-Seq_ESCs_Mouse1.91031990
25EZH2_27294783_Chip-Seq_NPCs_Mouse1.90336139
26* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88245209
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86737452
28E2F1_18555785_Chip-Seq_ESCs_Mouse1.86457198
29EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.85505175
30P300_19829295_ChIP-Seq_ESCs_Human1.85024676
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80626548
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80545118
33EZH2_22144423_ChIP-Seq_EOC_Human1.77695086
34SUZ12_18555785_Chip-Seq_ESCs_Mouse1.77539226
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73384699
36ELK1_19687146_ChIP-ChIP_HELA_Human1.72286384
37P53_22387025_ChIP-Seq_ESCs_Mouse1.71899996
38STAT3_18555785_Chip-Seq_ESCs_Mouse1.71638193
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69995768
40CMYC_18555785_Chip-Seq_ESCs_Mouse1.68152166
41P300_18555785_Chip-Seq_ESCs_Mouse1.66115969
42RNF2_27304074_Chip-Seq_NSC_Mouse1.64038753
43NMYC_18555785_Chip-Seq_ESCs_Mouse1.63242043
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62910785
45FUS_26573619_Chip-Seq_HEK293_Human1.62430487
46EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.62224576
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.61738129
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.59556898
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58089189
50CBP_20019798_ChIP-Seq_JUKART_Human1.58089189
51OCT4_18555785_Chip-Seq_ESCs_Mouse1.55147803
52RUNX1_27457419_Chip-Seq_LIVER_Mouse1.53709731
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.53382990
54SOX2_18555785_Chip-Seq_ESCs_Mouse1.52590320
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52075496
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51361596
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51272218
58ER_23166858_ChIP-Seq_MCF-7_Human1.48813886
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.46961754
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45194390
61IRF1_19129219_ChIP-ChIP_H3396_Human1.44235882
62PU1_27457419_Chip-Seq_LIVER_Mouse1.43210787
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42930615
64* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42485438
65BCAT_22108803_ChIP-Seq_LS180_Human1.42160968
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40893468
67ZFX_18555785_Chip-Seq_ESCs_Mouse1.37907126
68KLF4_18555785_Chip-Seq_ESCs_Mouse1.37858720
69AR_25329375_ChIP-Seq_VCAP_Human1.37501176
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37223255
71SMAD4_21799915_ChIP-Seq_A2780_Human1.36391029
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34855618
73CTCF_18555785_Chip-Seq_ESCs_Mouse1.34736046
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33652749
75ESRRB_18555785_Chip-Seq_ESCs_Mouse1.32053608
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.32004963
77TCF4_22108803_ChIP-Seq_LS180_Human1.31721633
78VDR_23849224_ChIP-Seq_CD4+_Human1.31465173
79SMAD1_18555785_Chip-Seq_ESCs_Mouse1.31372784
80* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30692814
81* CRX_20693478_ChIP-Seq_RETINA_Mouse1.30172822
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27639994
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.26893471
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.26271712
85VDR_22108803_ChIP-Seq_LS180_Human1.25276048
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24770652
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24139694
88* TP53_22573176_ChIP-Seq_HFKS_Human1.23863532
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23040566
90RUNX_20019798_ChIP-Seq_JUKART_Human1.21308566
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.20885150
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.20835157
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20659632
94* FLI1_21867929_ChIP-Seq_TH2_Mouse1.20487924
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20021821
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20021821
97NANOG_19829295_ChIP-Seq_ESCs_Human1.19009666
98SOX2_19829295_ChIP-Seq_ESCs_Human1.19009666
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18820583
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18616077
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17857588
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15739102
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15341792
104* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15041897
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14577435
106MYC_18940864_ChIP-ChIP_HL60_Human1.13804295
107E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12682409
108TCF4_23295773_ChIP-Seq_U87_Human1.12555601
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.11433939
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10625296
111* PRDM14_20953172_ChIP-Seq_ESCs_Human1.10396415
112* STAT3_23295773_ChIP-Seq_U87_Human1.09908884
113* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09542679
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09382625
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07599780
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.07288407
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.06478821
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06436628
119* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06293846
120JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06265955
121AR_21572438_ChIP-Seq_LNCaP_Human1.06064516
122CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04571863
123CDX2_22108803_ChIP-Seq_LS180_Human1.04415186
124* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04154132
125EZH2_27304074_Chip-Seq_ESCs_Mouse1.04042291
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03469886
127RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01941903
128RUNX2_22187159_ChIP-Seq_PCA_Human0.99931557
129TCF4_18268006_ChIP-ChIP_LS174T_Human0.99353651
130* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97700173
131TP53_18474530_ChIP-ChIP_U2OS_Human0.97115107
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97100452
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96033234
134* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95400384
135IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94528671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.02267069
2MP0008057_abnormal_DNA_replication2.96945192
3MP0005409_darkened_coat_color2.85954738
4MP0006292_abnormal_olfactory_placode2.69169039
5MP0003195_calcinosis2.58244571
6MP0003787_abnormal_imprinting2.57188298
7MP0002163_abnormal_gland_morphology2.54714645
8MP0005551_abnormal_eye_electrophysiolog2.39407888
9MP0003136_yellow_coat_color2.29288756
10MP0003763_abnormal_thymus_physiology2.25494685
11MP0002837_dystrophic_cardiac_calcinosis2.25472196
12MP0005379_endocrine/exocrine_gland_phen2.20441591
13MP0008058_abnormal_DNA_repair2.17095798
14MP0008877_abnormal_DNA_methylation2.15955267
15MP0002009_preneoplasia2.12112261
16MP0001835_abnormal_antigen_presentation2.05214532
17MP0002277_abnormal_respiratory_mucosa2.03827985
18MP0010094_abnormal_chromosome_stability1.93862373
19MP0002102_abnormal_ear_morphology1.93052569
20MP0004147_increased_porphyrin_level1.89128569
21MP0005671_abnormal_response_to1.88725321
22MP0003941_abnormal_skin_development1.83450703
23MP0005253_abnormal_eye_physiology1.82516618
24MP0005646_abnormal_pituitary_gland1.76454572
25MP0009046_muscle_twitch1.72664538
26MP0000566_synostosis1.70104161
27MP0005171_absent_coat_pigmentation1.67754268
28MP0005387_immune_system_phenotype1.67733503
29MP0001790_abnormal_immune_system1.67733503
30MP0002396_abnormal_hematopoietic_system1.67169066
31MP0003011_delayed_dark_adaptation1.66988475
32MP0001346_abnormal_lacrimal_gland1.64556254
33MP0005645_abnormal_hypothalamus_physiol1.62544619
34MP0000015_abnormal_ear_pigmentation1.58149995
35MP0000427_abnormal_hair_cycle1.56012820
36MP0004381_abnormal_hair_follicle1.55902139
37MP0001486_abnormal_startle_reflex1.53965528
38MP0009745_abnormal_behavioral_response1.53365719
39MP0001485_abnormal_pinna_reflex1.52975568
40MP0008007_abnormal_cellular_replicative1.50827174
41MP0005386_behavior/neurological_phenoty1.50316546
42MP0004924_abnormal_behavior1.50316546
43MP0000569_abnormal_digit_pigmentation1.45263721
44MP0001800_abnormal_humoral_immune1.44975843
45MP0003718_maternal_effect1.40612432
46MP0002272_abnormal_nervous_system1.37671194
47MP0003111_abnormal_nucleus_morphology1.37549078
48MP0002751_abnormal_autonomic_nervous1.37401772
49MP0001501_abnormal_sleep_pattern1.37260686
50MP0008260_abnormal_autophagy1.36008908
51MP0003122_maternal_imprinting1.35909367
52MP0000516_abnormal_urinary_system1.33905192
53MP0005367_renal/urinary_system_phenotyp1.33905192
54MP0008789_abnormal_olfactory_epithelium1.33716443
55MP0008995_early_reproductive_senescence1.32972506
56MP0002148_abnormal_hypersensitivity_rea1.32397483
57MP0003786_premature_aging1.28042312
58MP0004885_abnormal_endolymph1.27182939
59MP0001293_anophthalmia1.26784244
60MP0001984_abnormal_olfaction1.26411916
61MP0002095_abnormal_skin_pigmentation1.25735708
62MP0001324_abnormal_eye_pigmentation1.25557630
63MP0004142_abnormal_muscle_tone1.23827187
64MP0005394_taste/olfaction_phenotype1.23229760
65MP0005499_abnormal_olfactory_system1.23229760
66MP0005000_abnormal_immune_tolerance1.22673861
67MP0003567_abnormal_fetal_cardiomyocyte1.22437684
68MP0001819_abnormal_immune_cell1.21925533
69MP0003121_genomic_imprinting1.21923779
70MP0002420_abnormal_adaptive_immunity1.21489920
71MP0009785_altered_susceptibility_to1.21410794
72MP0003880_abnormal_central_pattern1.20457908
73MP0002723_abnormal_immune_serum1.20302693
74MP0002398_abnormal_bone_marrow1.20291733
75MP0002452_abnormal_antigen_presenting1.18195661
76MP0000383_abnormal_hair_follicle1.15540852
77MP0003315_abnormal_perineum_morphology1.15487492
78MP0004215_abnormal_myocardial_fiber1.14455268
79MP0003077_abnormal_cell_cycle1.13338496
80MP0005310_abnormal_salivary_gland1.13190254
81MP0002067_abnormal_sensory_capabilities1.11157144
82MP0006276_abnormal_autonomic_nervous1.10201354
83MP0001986_abnormal_taste_sensitivity1.09559421
84MP0002572_abnormal_emotion/affect_behav1.07673415
85MP0002653_abnormal_ependyma_morphology1.06638012
86MP0000647_abnormal_sebaceous_gland1.06295659
87MP0004133_heterotaxia1.05388651
88MP0005174_abnormal_tail_pigmentation1.05133588
89MP0002405_respiratory_system_inflammati1.04490377
90MP0002557_abnormal_social/conspecific_i1.04231609
91MP0000716_abnormal_immune_system1.03750805
92MP0005195_abnormal_posterior_eye1.02832859
93MP0002234_abnormal_pharynx_morphology1.01614922
94MP0000703_abnormal_thymus_morphology0.99753562
95MP0000613_abnormal_salivary_gland0.99523651
96MP0001929_abnormal_gametogenesis0.99444461
97MP0006054_spinal_hemorrhage0.99266275
98MP0002736_abnormal_nociception_after0.98337885
99MP0002752_abnormal_somatic_nervous0.98057193
100MP0005451_abnormal_body_composition0.96567341
101MP0003698_abnormal_male_reproductive0.95754605
102MP0002160_abnormal_reproductive_system0.95523775
103MP0003890_abnormal_embryonic-extraembry0.95214658
104MP0000685_abnormal_immune_system0.95186517
105MP0006072_abnormal_retinal_apoptosis0.94540694
106MP0004808_abnormal_hematopoietic_stem0.94513979
107MP0002734_abnormal_mechanical_nocicepti0.93628216
108MP0004742_abnormal_vestibular_system0.93326558
109MP0002210_abnormal_sex_determination0.92728709
110MP0000631_abnormal_neuroendocrine_gland0.92449824
111MP0000372_irregular_coat_pigmentation0.92396270
112MP0008872_abnormal_physiological_respon0.92389182
113MP0003937_abnormal_limbs/digits/tail_de0.90475761
114MP0002876_abnormal_thyroid_physiology0.89251178
115MP0001119_abnormal_female_reproductive0.89190331
116MP0002006_tumorigenesis0.88919125
117MP0001186_pigmentation_phenotype0.88123800
118MP0000026_abnormal_inner_ear0.87891640
119MP0003828_pulmonary_edema0.86589469
120MP0002063_abnormal_learning/memory/cond0.86195720
121MP0000653_abnormal_sex_gland0.86076614
122MP0003119_abnormal_digestive_system0.85797840
123MP0005075_abnormal_melanosome_morpholog0.85659824
124MP0005391_vision/eye_phenotype0.85478134
125MP0003635_abnormal_synaptic_transmissio0.85140544
126MP0001529_abnormal_vocalization0.85019995
127MP0002064_seizures0.84922602
128MP0004270_analgesia0.84825084
129MP0002233_abnormal_nose_morphology0.84445010
130MP0001968_abnormal_touch/_nociception0.84052151
131MP0001919_abnormal_reproductive_system0.83772447
132MP0002938_white_spotting0.81682116
133MP0002132_abnormal_respiratory_system0.81025869
134MP0006035_abnormal_mitochondrial_morpho0.80381331
135MP0000778_abnormal_nervous_system0.80283166
136MP0002735_abnormal_chemical_nociception0.79970082
137MP0002928_abnormal_bile_duct0.79944668
138MP0009250_abnormal_appendicular_skeleto0.79552445
139MP0003693_abnormal_embryo_hatching0.79291419
140MP0005025_abnormal_response_to0.79096248
141MP0002638_abnormal_pupillary_reflex0.78844509
142MP0005389_reproductive_system_phenotype0.78843582
143MP0001145_abnormal_male_reproductive0.78318416
144MP0001286_abnormal_eye_development0.78021141
145MP0003724_increased_susceptibility_to0.77921532
146MP0002419_abnormal_innate_immunity0.77798815
147MP0009697_abnormal_copulation0.77738567
148MP0000049_abnormal_middle_ear0.76943073
149MP0002075_abnormal_coat/hair_pigmentati0.76907475
150MP0005248_abnormal_Harderian_gland0.76667763
151MP0002882_abnormal_neuron_morphology0.76459015
152MP0002722_abnormal_immune_system0.76134339
153MP0002229_neurodegeneration0.75485902
154MP0000689_abnormal_spleen_morphology0.75172949
155MP0002184_abnormal_innervation0.73784730
156MP0000955_abnormal_spinal_cord0.71848474

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.38102130
2Chromsome breakage (HP:0040012)5.10489300
3Pancreatic cysts (HP:0001737)4.01517015
4Molar tooth sign on MRI (HP:0002419)3.81531573
5Abnormality of midbrain morphology (HP:0002418)3.81531573
6Pancreatic fibrosis (HP:0100732)3.78736603
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.12647837
8Type II lissencephaly (HP:0007260)3.08248573
9Genital tract atresia (HP:0001827)3.08151223
10Lip pit (HP:0100267)3.05621588
11Volvulus (HP:0002580)3.04476663
12Abnormality of the preputium (HP:0100587)2.98429066
13Abnormality of the renal collecting system (HP:0004742)2.96094426
14Duplicated collecting system (HP:0000081)2.95337065
15Prostate neoplasm (HP:0100787)2.90983507
16Vaginal atresia (HP:0000148)2.88945601
17Hyperventilation (HP:0002883)2.83171007
18Meckel diverticulum (HP:0002245)2.79707588
19Congenital stationary night blindness (HP:0007642)2.75463703
20Abnormality of the renal cortex (HP:0011035)2.72761723
21Abnormality of chromosome stability (HP:0003220)2.68948029
22Progressive inability to walk (HP:0002505)2.64888618
23Abnormality of the ileum (HP:0001549)2.63841062
24Febrile seizures (HP:0002373)2.63786174
25Abnormality of DNA repair (HP:0003254)2.63673667
26Gaze-evoked nystagmus (HP:0000640)2.63341265
27Clubbing of toes (HP:0100760)2.62986002
28Chronic hepatic failure (HP:0100626)2.60909969
29Lissencephaly (HP:0001339)2.57679241
30Abnormal hair whorl (HP:0010721)2.56995261
31Ectopic kidney (HP:0000086)2.56464186
32Intestinal atresia (HP:0011100)2.46509383
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.42660895
34Inability to walk (HP:0002540)2.40349789
35Retinal dysplasia (HP:0007973)2.37839268
36Abnormality of the fingertips (HP:0001211)2.37719241
37Methylmalonic acidemia (HP:0002912)2.35630548
38Hypothermia (HP:0002045)2.34338389
39Retrobulbar optic neuritis (HP:0100654)2.31338617
40Optic neuritis (HP:0100653)2.31338617
41Absent/shortened dynein arms (HP:0200106)2.29931518
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.29931518
43Abnormality of the nasal septum (HP:0000419)2.25983127
44Abnormality of incisor morphology (HP:0011063)2.24470244
45Nephroblastoma (Wilms tumor) (HP:0002667)2.22690305
46Septo-optic dysplasia (HP:0100842)2.20960234
47Anencephaly (HP:0002323)2.19636964
48Attenuation of retinal blood vessels (HP:0007843)2.19463203
49Abnormality of the prostate (HP:0008775)2.17952588
50Upper limb muscle weakness (HP:0003484)2.17604298
51Neoplasm of the adrenal cortex (HP:0100641)2.15558825
52Broad-based gait (HP:0002136)2.14681618
53Drooling (HP:0002307)2.14674326
54Cystic liver disease (HP:0006706)2.14450868
55Renal cortical cysts (HP:0000803)2.13971410
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13883572
57Eosinophilia (HP:0001880)2.12205637
58Nephronophthisis (HP:0000090)2.11627746
59Nephrogenic diabetes insipidus (HP:0009806)2.11418037
60Medial flaring of the eyebrow (HP:0010747)2.09560945
61Stomatitis (HP:0010280)2.08812831
62Aplasia/Hypoplasia of the tibia (HP:0005772)2.08655204
63Embryonal renal neoplasm (HP:0011794)2.08411004
64Postaxial hand polydactyly (HP:0001162)2.06529608
65Obstructive lung disease (HP:0006536)2.06386709
66Chronic obstructive pulmonary disease (HP:0006510)2.06386709
67Agammaglobulinemia (HP:0004432)2.04849077
68Sclerocornea (HP:0000647)2.04625037
69Recurrent pneumonia (HP:0006532)2.04584848
70Autoimmune hemolytic anemia (HP:0001890)2.03566252
71Protruding tongue (HP:0010808)2.02897561
72Duodenal stenosis (HP:0100867)2.01146798
73Small intestinal stenosis (HP:0012848)2.01146798
74Tubulointerstitial nephritis (HP:0001970)2.00934058
75Abnormality of the columella (HP:0009929)2.00419691
76Cerebellar dysplasia (HP:0007033)1.99946582
77Dandy-Walker malformation (HP:0001305)1.99554915
78Abnormal rod and cone electroretinograms (HP:0008323)1.98656906
79Excessive salivation (HP:0003781)1.98473457
80Acute myeloid leukemia (HP:0004808)1.97392392
81Narrow forehead (HP:0000341)1.96614022
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96426390
83Stomach cancer (HP:0012126)1.95990132
84Abnormality of the carotid arteries (HP:0005344)1.95260674
85Tubular atrophy (HP:0000092)1.94705597
86White forelock (HP:0002211)1.93958385
87True hermaphroditism (HP:0010459)1.93911845
88Colon cancer (HP:0003003)1.93317307
89Oligodactyly (hands) (HP:0001180)1.93205814
90Congenital hepatic fibrosis (HP:0002612)1.90821748
91Abnormal biliary tract physiology (HP:0012439)1.89400782
92Bile duct proliferation (HP:0001408)1.89400782
93Specific learning disability (HP:0001328)1.89181243
94Median cleft lip (HP:0000161)1.88937230
95Abolished electroretinogram (ERG) (HP:0000550)1.88784707
96Recurrent fungal infections (HP:0002841)1.88468213
97Abnormality of eosinophils (HP:0001879)1.88443809
98Thyroiditis (HP:0100646)1.88298770
99Renal dysplasia (HP:0000110)1.87215682
100Myelodysplasia (HP:0002863)1.87046803
101Aplasia cutis congenita (HP:0001057)1.86728099
102Bone marrow hypocellularity (HP:0005528)1.86507938
103Abnormality of the renal medulla (HP:0100957)1.86240778
104Postaxial foot polydactyly (HP:0001830)1.85695440
105Osteomalacia (HP:0002749)1.85016798
106Furrowed tongue (HP:0000221)1.84942431
107Abnormality of alanine metabolism (HP:0010916)1.84885522
108Hyperalaninemia (HP:0003348)1.84885522
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84885522
110Congenital primary aphakia (HP:0007707)1.84219737
111Panhypogammaglobulinemia (HP:0003139)1.83729362
112Gait imbalance (HP:0002141)1.83447670
113Gastrointestinal atresia (HP:0002589)1.82068443
114Sloping forehead (HP:0000340)1.79691491
115Optic nerve hypoplasia (HP:0000609)1.78969831
116Mesomelia (HP:0003027)1.78918571
117Abnormality of the incisor (HP:0000676)1.78693852
118Glioma (HP:0009733)1.78558771
119Bifid tongue (HP:0010297)1.77752103
120Meningitis (HP:0001287)1.77529787
121Poor coordination (HP:0002370)1.76502494
122Preaxial hand polydactyly (HP:0001177)1.76442169
123Granulocytopenia (HP:0001913)1.76396302
124Broad foot (HP:0001769)1.76385999
125Mediastinal lymphadenopathy (HP:0100721)1.75662140
126Methylmalonic aciduria (HP:0012120)1.75613694
127Duplication of thumb phalanx (HP:0009942)1.75312282
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74710819
129Small hand (HP:0200055)1.73172149
130Abnormality of the labia minora (HP:0012880)1.72711423
131Recurrent sinusitis (HP:0011108)1.72019724
132Recurrent viral infections (HP:0004429)1.70769681
133Cupped ear (HP:0000378)1.70609057
134Labial hypoplasia (HP:0000066)1.70159924
135Leukocytosis (HP:0001974)1.69958726
136Abnormality of homocysteine metabolism (HP:0010919)1.69806418
137Homocystinuria (HP:0002156)1.69806418
138Fair hair (HP:0002286)1.69435806
139Chronic mucocutaneous candidiasis (HP:0002728)1.68915351
140Recurrent cutaneous fungal infections (HP:0011370)1.68915351
141Bony spicule pigmentary retinopathy (HP:0007737)1.68893501
142Patchy hypopigmentation of hair (HP:0011365)1.68526184
143Severe combined immunodeficiency (HP:0004430)1.68162813
144Abnormal ciliary motility (HP:0012262)1.67931789
145Focal motor seizures (HP:0011153)1.67126735
146Astigmatism (HP:0000483)1.67123590
147Asplenia (HP:0001746)1.66372131
148Increased IgM level (HP:0003496)1.66203619
149Oligohydramnios (HP:0001562)1.65861089
150Multicystic kidney dysplasia (HP:0000003)1.65555767
151Pendular nystagmus (HP:0012043)1.65399236
152Constricted visual fields (HP:0001133)1.64838934
153Abnormality of T cell number (HP:0011839)1.64218262
154Abnormal delayed hypersensitivity skin test (HP:0002963)1.64169362
155Chronic diarrhea (HP:0002028)1.64127079
156Short foot (HP:0001773)1.63391995
157Widely spaced teeth (HP:0000687)1.63305320
158Spinal cord lesions (HP:0100561)1.63243111
159Syringomyelia (HP:0003396)1.63243111
160Prominent nasal bridge (HP:0000426)1.63073461
161Progressive cerebellar ataxia (HP:0002073)1.62972438
162IgM deficiency (HP:0002850)1.62740992
163Triphalangeal thumb (HP:0001199)1.61451725
164Chorioretinal coloboma (HP:0000567)1.60721800
165Abnormality of the duodenum (HP:0002246)1.60161860
166Male pseudohermaphroditism (HP:0000037)1.59778544
167Abnormality of male internal genitalia (HP:0000022)1.58974984
168Aganglionic megacolon (HP:0002251)1.58790469
169Dyschromatopsia (HP:0007641)1.58720405
170Absent speech (HP:0001344)1.58096234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.10168144
2TXK3.44088851
3MAP4K23.35331866
4MAP3K142.40041560
5ZAK2.35235409
6TRIM282.35217585
7SIK32.29831640
8STK162.28643987
9MKNK22.10613610
10NEK12.01695783
11SRPK12.01597199
12CLK11.99091079
13ADRBK21.97517204
14TNIK1.92833803
15EIF2AK21.88650786
16IRAK41.83232440
17YES11.81962868
18BRD41.78974059
19BMPR21.77248358
20BRSK21.72680961
21MAP2K71.66926388
22EPHA31.66679441
23NUAK11.65782795
24NLK1.62856119
25INSRR1.60624868
26NEK61.51966138
27TAOK31.47496887
28PINK11.44151544
29PNCK1.40015265
30CDK31.38330491
31PAK31.37001838
32EPHA41.34879964
33TEC1.31596217
34BCR1.31266434
35MARK11.29248112
36SGK21.27658698
37MKNK11.23308404
38MAPK131.22514099
39IRAK11.21923633
40BMPR1B1.20873344
41FGFR21.17565592
42WEE11.15486925
43MAP4K11.14746554
44IRAK31.14443646
45PLK41.13565762
46PRPF4B1.11647066
47VRK11.10831160
48CHEK21.09882774
49IKBKB1.09261131
50AKT31.08627619
51OXSR11.07268827
52PLK21.07092452
53STK31.05866995
54MUSK1.05670859
55CDK81.04987501
56MAP3K121.04059509
57JAK31.02451576
58NTRK31.00061019
59CSNK1G10.96990846
60IKBKE0.96056206
61ATR0.94377631
62GRK70.93425992
63PKN10.93012200
64GRK10.91055966
65CDK120.90921882
66TNK20.90183765
67STK240.87252737
68TSSK60.84984798
69CSNK1G20.84417004
70CHUK0.82650719
71DYRK30.79668875
72RIPK40.79494984
73BTK0.79464327
74NEK20.79250865
75STK390.77330873
76STK38L0.76483000
77LCK0.75868425
78PLK30.75102811
79CAMKK20.73649028
80TGFBR10.72170976
81ITK0.70818712
82SYK0.69749802
83PRKCG0.69662153
84BUB10.67722519
85CSNK1G30.66997425
86TAOK20.65358881
87ACVR1B0.64842126
88CDK70.64821453
89TAF10.63561756
90PLK10.63442522
91PRKCQ0.63392094
92PRKCE0.63282358
93ERBB30.63049107
94MAP3K130.62014895
95SGK2230.61106770
96SGK4940.61106770
97ATM0.60305293
98FGFR30.58530989
99WNK40.58494039
100LYN0.58176717
101PRKD20.57140165
102IRAK20.55155211
103TLK10.54240144
104DAPK20.53662680
105TRPM70.53360042
106JAK10.52416478
107ADRBK10.51773784
108MAP3K40.51236856
109FER0.50978829
110TTK0.50645972
111STK40.50580565
112PASK0.50035051
113CHEK10.48364427
114MINK10.47158707
115HCK0.47146837
116SGK30.46549934
117KIT0.45868575
118FES0.44341414
119EIF2AK30.44242745
120CDC70.43751184
121RPS6KA50.43279181
122PIM10.42201959
123RPS6KA40.41753075
124CSNK1A10.41637332
125EPHB10.41350994
126MAPK70.39263659
127SGK10.39126328
128CSNK1D0.38965182
129STK110.38123352
130CAMK2A0.37940843
131DYRK20.37788355
132PIK3CA0.37642583
133MST40.37116110
134CSNK1A1L0.35821095
135CAMK2B0.34630823
136CSF1R0.34623364
137EIF2AK10.34615800
138CCNB10.34177251
139CDK10.33616347
140DYRK1A0.33157265
141PRKG10.32603009
142FRK0.32298339
143NTRK20.31974695
144KSR10.31078426
145FGFR10.31024715
146WNK30.30688260
147PRKAA10.30509224
148RPS6KB10.30494828
149LATS10.30441464
150PRKACB0.30384613
151PRKACA0.29173974
152MAP2K40.28762692
153OBSCN0.26574843
154CAMK40.25527815

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004502.90455848
2Fanconi anemia pathway_Homo sapiens_hsa034602.87772309
3Graft-versus-host disease_Homo sapiens_hsa053322.81037975
4Protein export_Homo sapiens_hsa030602.75499715
5Non-homologous end-joining_Homo sapiens_hsa034502.42567198
6Primary immunodeficiency_Homo sapiens_hsa053402.27926850
7Allograft rejection_Homo sapiens_hsa053302.26114011
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18265843
9Propanoate metabolism_Homo sapiens_hsa006402.14820544
10Homologous recombination_Homo sapiens_hsa034402.06493247
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.97429321
12Butanoate metabolism_Homo sapiens_hsa006501.92457315
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.86467645
14Regulation of autophagy_Homo sapiens_hsa041401.86461557
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86280451
16Autoimmune thyroid disease_Homo sapiens_hsa053201.84870951
17Steroid biosynthesis_Homo sapiens_hsa001001.78939606
18Mismatch repair_Homo sapiens_hsa034301.73215800
19Nitrogen metabolism_Homo sapiens_hsa009101.68952693
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.64662758
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60622914
22Hematopoietic cell lineage_Homo sapiens_hsa046401.60318138
23Type I diabetes mellitus_Homo sapiens_hsa049401.59970506
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59203218
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57364926
26Measles_Homo sapiens_hsa051621.54316918
27Basal transcription factors_Homo sapiens_hsa030221.52444284
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47969764
29RNA degradation_Homo sapiens_hsa030181.46626709
30Asthma_Homo sapiens_hsa053101.40525423
31Nicotine addiction_Homo sapiens_hsa050331.39985092
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38941983
33Phototransduction_Homo sapiens_hsa047441.38739786
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34243989
35Linoleic acid metabolism_Homo sapiens_hsa005911.34169204
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33006011
37T cell receptor signaling pathway_Homo sapiens_hsa046601.31060864
38Herpes simplex infection_Homo sapiens_hsa051681.28333985
39Cell cycle_Homo sapiens_hsa041101.26030752
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24490255
41Circadian rhythm_Homo sapiens_hsa047101.22668466
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22655510
43DNA replication_Homo sapiens_hsa030301.21714219
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21361774
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20924057
46Nucleotide excision repair_Homo sapiens_hsa034201.20421322
47Tryptophan metabolism_Homo sapiens_hsa003801.18658376
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15171774
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12334914
50Rheumatoid arthritis_Homo sapiens_hsa053231.10673478
51Caffeine metabolism_Homo sapiens_hsa002321.05190144
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05162590
53Proteasome_Homo sapiens_hsa030501.04220269
54Antigen processing and presentation_Homo sapiens_hsa046121.02689949
55Leishmaniasis_Homo sapiens_hsa051401.02533267
56Sulfur metabolism_Homo sapiens_hsa009201.01599151
57p53 signaling pathway_Homo sapiens_hsa041151.00879980
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99894454
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99168826
60Oxidative phosphorylation_Homo sapiens_hsa001900.95412813
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.95054789
62Dorso-ventral axis formation_Homo sapiens_hsa043200.94883809
63GABAergic synapse_Homo sapiens_hsa047270.94311502
64African trypanosomiasis_Homo sapiens_hsa051430.91134316
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91042600
66Long-term depression_Homo sapiens_hsa047300.89760157
67Circadian entrainment_Homo sapiens_hsa047130.89592278
68Osteoclast differentiation_Homo sapiens_hsa043800.88434045
69Influenza A_Homo sapiens_hsa051640.88376075
70Dopaminergic synapse_Homo sapiens_hsa047280.85766846
71ABC transporters_Homo sapiens_hsa020100.85007582
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84958938
73Chemokine signaling pathway_Homo sapiens_hsa040620.83102227
74TNF signaling pathway_Homo sapiens_hsa046680.83035416
75Oocyte meiosis_Homo sapiens_hsa041140.82668266
76Sphingolipid metabolism_Homo sapiens_hsa006000.82484903
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80466749
78RNA polymerase_Homo sapiens_hsa030200.79906661
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79603049
80B cell receptor signaling pathway_Homo sapiens_hsa046620.78665408
81Peroxisome_Homo sapiens_hsa041460.77082982
82Hedgehog signaling pathway_Homo sapiens_hsa043400.76303757
83Serotonergic synapse_Homo sapiens_hsa047260.76213639
84Insulin secretion_Homo sapiens_hsa049110.76001743
85Taste transduction_Homo sapiens_hsa047420.75713932
86Axon guidance_Homo sapiens_hsa043600.75683702
87Morphine addiction_Homo sapiens_hsa050320.74550362
88Systemic lupus erythematosus_Homo sapiens_hsa053220.74301082
89* mRNA surveillance pathway_Homo sapiens_hsa030150.73986667
90Epstein-Barr virus infection_Homo sapiens_hsa051690.72583419
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71256027
92MicroRNAs in cancer_Homo sapiens_hsa052060.71118329
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.70574030
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69713089
95Arachidonic acid metabolism_Homo sapiens_hsa005900.69683902
96Hepatitis B_Homo sapiens_hsa051610.68409393
97Ether lipid metabolism_Homo sapiens_hsa005650.67597233
98HTLV-I infection_Homo sapiens_hsa051660.66128646
99One carbon pool by folate_Homo sapiens_hsa006700.62836900
100Melanoma_Homo sapiens_hsa052180.62755079
101Parkinsons disease_Homo sapiens_hsa050120.61549328
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61119961
103Prostate cancer_Homo sapiens_hsa052150.60861705
104Spliceosome_Homo sapiens_hsa030400.60263524
105Malaria_Homo sapiens_hsa051440.59933162
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59440103
107Base excision repair_Homo sapiens_hsa034100.58449201
108Olfactory transduction_Homo sapiens_hsa047400.58168114
109Viral carcinogenesis_Homo sapiens_hsa052030.57865359
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57350098
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54687312
112Tuberculosis_Homo sapiens_hsa051520.54403973
113Basal cell carcinoma_Homo sapiens_hsa052170.52252664
114MAPK signaling pathway_Homo sapiens_hsa040100.52103588
115Pathways in cancer_Homo sapiens_hsa052000.51467761
116Glutamatergic synapse_Homo sapiens_hsa047240.51317713
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51306789
118Small cell lung cancer_Homo sapiens_hsa052220.51248755
119Pancreatic cancer_Homo sapiens_hsa052120.51163082
120ErbB signaling pathway_Homo sapiens_hsa040120.50876428
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50800583
122Wnt signaling pathway_Homo sapiens_hsa043100.50532143
123Calcium signaling pathway_Homo sapiens_hsa040200.50475387
124Collecting duct acid secretion_Homo sapiens_hsa049660.50350284
125Amphetamine addiction_Homo sapiens_hsa050310.49994491
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49436626
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49430283
128Toxoplasmosis_Homo sapiens_hsa051450.49214559
129Phagosome_Homo sapiens_hsa041450.49136742
130Ras signaling pathway_Homo sapiens_hsa040140.47880841
131Huntingtons disease_Homo sapiens_hsa050160.46495439
132Alcoholism_Homo sapiens_hsa050340.44777281
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43861666
134Colorectal cancer_Homo sapiens_hsa052100.43174532
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43168165
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43098694
137FoxO signaling pathway_Homo sapiens_hsa040680.42962059
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42790877
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42729116
140Salivary secretion_Homo sapiens_hsa049700.41940416
141RNA transport_Homo sapiens_hsa030130.41660697
142Purine metabolism_Homo sapiens_hsa002300.41393239
143TGF-beta signaling pathway_Homo sapiens_hsa043500.40656048
144Retinol metabolism_Homo sapiens_hsa008300.38283019
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.37474042
146Lysine degradation_Homo sapiens_hsa003100.37088909
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35024980
148Ovarian steroidogenesis_Homo sapiens_hsa049130.34636544
149Pyrimidine metabolism_Homo sapiens_hsa002400.33447760
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.33115514
151Vitamin B6 metabolism_Homo sapiens_hsa007500.32908295
152Metabolic pathways_Homo sapiens_hsa011000.31125631
153Legionellosis_Homo sapiens_hsa051340.30609808
154Chemical carcinogenesis_Homo sapiens_hsa052040.28644725
155cAMP signaling pathway_Homo sapiens_hsa040240.28459056
156Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25234025
157beta-Alanine metabolism_Homo sapiens_hsa004100.24882172

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