PAPPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gonadotropin secretion (GO:0032276)9.43483499
2estrogen metabolic process (GO:0008210)8.01439523
3glucocorticoid biosynthetic process (GO:0006704)8.00783613
4* female pregnancy (GO:0007565)7.75049594
5bone trabecula formation (GO:0060346)7.32959981
6mesenchymal-epithelial cell signaling (GO:0060638)7.28881333
7sequestering of extracellular ligand from receptor (GO:0035581)7.07449314
8prostate gland growth (GO:0060736)7.03406501
9collagen fibril organization (GO:0030199)6.32299213
10chondrocyte proliferation (GO:0035988)6.26868276
11androgen biosynthetic process (GO:0006702)6.14963527
12* multi-multicellular organism process (GO:0044706)5.59314288
13craniofacial suture morphogenesis (GO:0097094)5.43191301
14positive regulation of growth hormone secretion (GO:0060124)5.41127054
15androgen metabolic process (GO:0008209)5.28969401
16lateral sprouting from an epithelium (GO:0060601)5.11995046
17regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.98113281
18positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.97192298
19regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.90531519
20planar cell polarity pathway involved in neural tube closure (GO:0090179)4.88115989
21* multi-organism reproductive process (GO:0044703)4.88113409
22myoblast fusion (GO:0007520)4.88101777
23vascular endothelial growth factor signaling pathway (GO:0038084)4.81069425
24endodermal cell differentiation (GO:0035987)4.75333975
25glucocorticoid metabolic process (GO:0008211)4.73694953
26lymphangiogenesis (GO:0001946)4.70236149
27cellular response to vitamin D (GO:0071305)4.69889883
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.60571391
29protein heterotrimerization (GO:0070208)4.57692743
30axon extension involved in axon guidance (GO:0048846)4.54306658
31neuron projection extension involved in neuron projection guidance (GO:1902284)4.54306658
32chondrocyte development (GO:0002063)4.52573831
33prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.51062177
34endocrine hormone secretion (GO:0060986)4.49529358
35regulation of growth hormone secretion (GO:0060123)4.40908222
36cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.40192740
37syncytium formation by plasma membrane fusion (GO:0000768)4.34163131
38syncytium formation (GO:0006949)4.26027697
39cranial suture morphogenesis (GO:0060363)4.25351444
40extracellular regulation of signal transduction (GO:1900115)4.15308511
41extracellular negative regulation of signal transduction (GO:1900116)4.15308511
42lymph vessel development (GO:0001945)4.11880063
43skin morphogenesis (GO:0043589)4.04594433
44cellular response to vitamin (GO:0071295)4.03884066
45basement membrane organization (GO:0071711)4.02348600
46cell proliferation involved in kidney development (GO:0072111)3.96135353
47cell proliferation involved in metanephros development (GO:0072203)3.95316099
48hormone biosynthetic process (GO:0042446)3.93086553
49vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.91598725
50sprouting angiogenesis (GO:0002040)3.88292534
51protein localization to cell surface (GO:0034394)3.85927819
52collagen catabolic process (GO:0030574)3.84425492
53negative regulation of chondrocyte differentiation (GO:0032331)3.83409925
54dermatan sulfate biosynthetic process (GO:0030208)3.81770313
55collagen metabolic process (GO:0032963)3.79966871
56negative regulation of activin receptor signaling pathway (GO:0032926)3.77798945
57negative regulation of osteoblast proliferation (GO:0033689)3.74323688
58* response to follicle-stimulating hormone (GO:0032354)3.71794147
59mesenchymal cell proliferation (GO:0010463)3.65217608
60metanephric mesenchyme development (GO:0072075)3.63204244
61negative regulation of fatty acid transport (GO:2000192)3.62907136
62extracellular matrix assembly (GO:0085029)3.61321774
63branching involved in prostate gland morphogenesis (GO:0060442)3.59432114
64radial glial cell differentiation (GO:0060019)3.58429497
65wound healing, spreading of epidermal cells (GO:0035313)3.56118411
66axis elongation (GO:0003401)3.54853843
67collecting duct development (GO:0072044)3.53919117
68multicellular organismal macromolecule metabolic process (GO:0044259)3.53816260
69positive regulation of protein kinase C signaling (GO:0090037)3.51146648
70mesodermal cell differentiation (GO:0048333)3.50226007
71convergent extension (GO:0060026)3.48256741
72multicellular organismal catabolic process (GO:0044243)3.48030086
73substrate-dependent cell migration (GO:0006929)3.46177386
74dermatan sulfate metabolic process (GO:0030205)3.42382783
75branch elongation of an epithelium (GO:0060602)3.40454499
76cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.38830631
77cell adhesion mediated by integrin (GO:0033627)3.37267644
78keratinocyte proliferation (GO:0043616)3.34736609
79multicellular organismal metabolic process (GO:0044236)3.32859271
80kidney mesenchyme development (GO:0072074)3.32803365
81extracellular matrix disassembly (GO:0022617)3.32417604
82regulation of chondrocyte differentiation (GO:0032330)3.30312948
83negative regulation of catenin import into nucleus (GO:0035414)3.30262247
84Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.29139328
85endocardial cushion development (GO:0003197)3.28501577
86regulation of cartilage development (GO:0061035)3.28164954
87positive regulation of cartilage development (GO:0061036)3.27900335
88negative regulation of embryonic development (GO:0045992)3.26072270
89positive regulation of fibroblast migration (GO:0010763)3.25684037
90positive regulation of endothelial cell apoptotic process (GO:2000353)3.25156702
91regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.23286705
92regulation of non-canonical Wnt signaling pathway (GO:2000050)3.22591625
93embryonic cranial skeleton morphogenesis (GO:0048701)3.19806041
94regulation of establishment of planar polarity (GO:0090175)3.19285080
95regulation of osteoblast proliferation (GO:0033688)3.19067975
96limb bud formation (GO:0060174)3.16760999
97branching involved in salivary gland morphogenesis (GO:0060445)3.14629700
98G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.14549339
99positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.13781170
100negative chemotaxis (GO:0050919)3.11005214
101prostate gland epithelium morphogenesis (GO:0060740)3.10095564
102smooth muscle tissue development (GO:0048745)3.09934788
103pathway-restricted SMAD protein phosphorylation (GO:0060389)3.09315334
104JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.09270018
105hippo signaling (GO:0035329)3.08328112
106negative regulation of cartilage development (GO:0061037)3.07408024
107pericardium development (GO:0060039)3.03191270
108bone morphogenesis (GO:0060349)3.02808576
109venous blood vessel morphogenesis (GO:0048845)3.01066633
110cellular response to prostaglandin stimulus (GO:0071379)3.00251598
111negative regulation of cell-matrix adhesion (GO:0001953)2.98778724
112negative regulation of stem cell proliferation (GO:2000647)2.96159800
113positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.95479414
114insulin-like growth factor receptor signaling pathway (GO:0048009)2.93766444
115sphingoid metabolic process (GO:0046519)2.91921684
116positive regulation of smoothened signaling pathway (GO:0045880)2.91367622
117vitamin transmembrane transport (GO:0035461)2.90316772
118glomerular basement membrane development (GO:0032836)2.89431844
119wound healing, spreading of cells (GO:0044319)2.89196698
120negative regulation of BMP signaling pathway (GO:0030514)2.88992306
121trabecula formation (GO:0060343)2.88493831
122positive regulation of epithelial to mesenchymal transition (GO:0010718)2.88319403
123eyelid development in camera-type eye (GO:0061029)2.86778910
124retina vasculature morphogenesis in camera-type eye (GO:0061299)2.86619494
125positive regulation of macrophage activation (GO:0043032)2.85598468
126regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82760919
127positive regulation of extracellular matrix organization (GO:1903055)2.82635724
128type B pancreatic cell proliferation (GO:0044342)2.82507754
129extracellular matrix organization (GO:0030198)2.79907874
130extracellular structure organization (GO:0043062)2.78965739
131positive regulation of blood vessel endothelial cell migration (GO:0043536)2.78408933
132paraxial mesoderm development (GO:0048339)2.78347322
133cell migration involved in sprouting angiogenesis (GO:0002042)2.76749074
134epithelial to mesenchymal transition (GO:0001837)2.74170795
135positive regulation of mesenchymal cell proliferation (GO:0002053)2.73976775
136non-canonical Wnt signaling pathway (GO:0035567)2.73594210
137camera-type eye morphogenesis (GO:0048593)2.72854241
138regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.72740276
139lung vasculature development (GO:0060426)2.72295715
140cell migration involved in heart development (GO:0060973)2.71630020
141mesonephric tubule development (GO:0072164)2.70940619
142positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.70766616
143extracellular fibril organization (GO:0043206)2.70223010
144cardiac epithelial to mesenchymal transition (GO:0060317)2.68287340
145blood vessel morphogenesis (GO:0048514)2.68114913
146peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.68068553
147negative regulation of smooth muscle cell migration (GO:0014912)2.67985772
148heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.67828518
149peptidyl-proline hydroxylation (GO:0019511)2.67392187
150iron ion import (GO:0097286)2.67344364
151endothelial cell morphogenesis (GO:0001886)2.66258706
152blood vessel maturation (GO:0001955)2.64970032
153fibril organization (GO:0097435)2.64349353
154cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.63376339
155regulation of G0 to G1 transition (GO:0070316)2.60811479
156substrate adhesion-dependent cell spreading (GO:0034446)2.58884388
157regulation of endocrine process (GO:0044060)2.57469268
158UDP-N-acetylglucosamine metabolic process (GO:0006047)2.53036094
159polarized epithelial cell differentiation (GO:0030859)2.52836007
160protein hydroxylation (GO:0018126)2.50475031
161regulation of plasminogen activation (GO:0010755)2.49986470
162cartilage condensation (GO:0001502)2.49864472
163cell aggregation (GO:0098743)2.49864472
164regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.49632440
165negative regulation of axon extension involved in axon guidance (GO:0048843)2.49504217
166estrogen biosynthetic process (GO:0006703)18.1484545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human6.72271208
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.24215811
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.28763036
4EGR1_19032775_ChIP-ChIP_M12_Human3.04404053
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92630568
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.82014741
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.61064053
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.56526460
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52715661
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42645259
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.31236619
12* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.30142692
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21541305
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.19913448
15EZH2_22144423_ChIP-Seq_EOC_Human2.15324849
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13600112
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13600112
18GBX2_23144817_ChIP-Seq_PC3_Human2.09962836
19* CJUN_26792858_Chip-Seq_BT549_Human2.09837581
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07541573
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02870490
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01804000
23* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99701008
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96463183
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.96277502
26TP53_18474530_ChIP-ChIP_U2OS_Human1.95838789
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.93303904
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.93074837
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.86847315
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.85460779
31* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81842192
32* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81616319
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81535558
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80799420
35* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.79503364
36* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.79503364
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78584503
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.77864286
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72966997
40AR_21572438_ChIP-Seq_LNCaP_Human1.70562421
41* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69320389
42* BRD4_25478319_ChIP-Seq_HGPS_Human1.66888800
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65807014
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63231856
45* TP53_20018659_ChIP-ChIP_R1E_Mouse1.61552452
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59650475
47TP53_16413492_ChIP-PET_HCT116_Human1.59216728
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57810076
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55431541
50* PIAS1_25552417_ChIP-Seq_VCAP_Human1.54054731
51* RNF2_27304074_Chip-Seq_ESCs_Mouse1.52485895
52* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51948347
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.47394069
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44661177
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43497149
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.42515922
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37866109
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37211798
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.31742948
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29113462
61UBF1/2_26484160_Chip-Seq_HMECs_Human1.28698643
62* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28104902
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28079941
64AHR_22903824_ChIP-Seq_MCF-7_Human1.26703861
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25464884
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24197862
67SMAD4_21799915_ChIP-Seq_A2780_Human1.22621095
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22384743
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21565860
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19801139
71ESR1_21235772_ChIP-Seq_MCF-7_Human1.19611913
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19521269
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18848313
74* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18015105
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17725597
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17459910
77TP63_23658742_ChIP-Seq_EP156T_Human1.17393219
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16778500
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.16547975
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.16320618
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15283117
82* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14419001
83BCAT_22108803_ChIP-Seq_LS180_Human1.13592527
84* SA1_22415368_ChIP-Seq_MEFs_Mouse1.12690073
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11373573
86SOX2_20726797_ChIP-Seq_SW620_Human1.09769592
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09533251
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09201677
89* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08847031
90* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08111858
91RXR_22108803_ChIP-Seq_LS180_Human1.08037998
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.08010165
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06883070
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06712707
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06712707
96* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05507144
97* P300_19829295_ChIP-Seq_ESCs_Human1.05448218
98* EZH2_27294783_Chip-Seq_ESCs_Mouse1.04230084
99* CBX2_27304074_Chip-Seq_ESCs_Mouse1.04129300
100TP53_23651856_ChIP-Seq_MEFs_Mouse1.02720655
101SMAD3_21741376_ChIP-Seq_HESCs_Human1.02658047
102TP53_22127205_ChIP-Seq_IMR90_Human1.02195147
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01448271
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01356685
105* RING1B_27294783_Chip-Seq_NPCs_Mouse1.01152466
106DROSHA_22980978_ChIP-Seq_HELA_Human1.00835607
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00585597
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00016011
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.98552657
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.98552657
111* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98346378
112* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97770790
113EGR1_19374776_ChIP-ChIP_THP-1_Human0.97418785
114SMAD3_21741376_ChIP-Seq_EPCs_Human0.96027158
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95129038
116* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94787238
117* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94729351
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.94019922
119CLOCK_20551151_ChIP-Seq_293T_Human0.93241788
120RING1B_27294783_Chip-Seq_ESCs_Mouse0.93105246
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92904497
122SALL1_21062744_ChIP-ChIP_HESCs_Human0.92888524
123* FOXO3_23340844_ChIP-Seq_DLD1_Human0.92864348
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92192364
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91584985
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89232887
127* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89184418
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89095718
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88060782
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87499946
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87294601
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87260926
133ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86266280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.05267442
2MP0009697_abnormal_copulation6.38039702
3MP0005503_abnormal_tendon_morphology5.72920107
4MP0005275_abnormal_skin_tensile4.93080611
5MP0003279_aneurysm3.20179331
6MP0002163_abnormal_gland_morphology3.10477359
7MP0004272_abnormal_basement_membrane2.98713492
8MP0003705_abnormal_hypodermis_morpholog2.88433364
9MP0009250_abnormal_appendicular_skeleto2.79864454
10MP0005257_abnormal_intraocular_pressure2.78909936
11MP0001958_emphysema2.73270028
12MP0009384_cardiac_valve_regurgitation2.70310781
13MP0006276_abnormal_autonomic_nervous2.61804703
14MP0005623_abnormal_meninges_morphology2.56753115
15MP0001299_abnormal_eye_distance/2.42671406
16MP0005508_abnormal_skeleton_morphology2.42246179
17MP0004134_abnormal_chest_morphology2.36605289
18MP0010030_abnormal_orbit_morphology2.29885665
19MP0003385_abnormal_body_wall2.27144680
20MP0002295_abnormal_pulmonary_circulatio2.22319380
21MP0005379_endocrine/exocrine_gland_phen2.14315845
22MP0002282_abnormal_trachea_morphology2.12575934
23MP0002108_abnormal_muscle_morphology1.94590424
24MP0001879_abnormal_lymphatic_vessel1.92031358
25MP0002938_white_spotting1.86652199
26MP0003942_abnormal_urinary_system1.86164383
27MP0009053_abnormal_anal_canal1.84081235
28MP0000428_abnormal_craniofacial_morphol1.73671728
29MP0003566_abnormal_cell_adhesion1.65641390
30MP0002896_abnormal_bone_mineralization1.64858537
31MP0000534_abnormal_ureter_morphology1.57666539
32MP0002932_abnormal_joint_morphology1.54689192
33MP0002115_abnormal_skeleton_extremities1.54109244
34MP0000163_abnormal_cartilage_morphology1.53035692
35MP0003755_abnormal_palate_morphology1.52024404
36MP0000566_synostosis1.51054132
37MP0010352_gastrointestinal_tract_polyps1.49994453
38MP0003959_abnormal_lean_body1.45653491
39MP0005187_abnormal_penis_morphology1.45224040
40MP0003950_abnormal_plasma_membrane1.43496026
41MP0000516_abnormal_urinary_system1.43276960
42MP0005367_renal/urinary_system_phenotyp1.43276960
43MP0001919_abnormal_reproductive_system1.43150947
44MP0001348_abnormal_lacrimal_gland1.43061197
45MP0002060_abnormal_skin_morphology1.42879001
46MP0005647_abnormal_sex_gland1.42251905
47MP0003941_abnormal_skin_development1.42121023
48MP0001243_abnormal_dermal_layer1.41322503
49MP0005023_abnormal_wound_healing1.38973265
50MP0003937_abnormal_limbs/digits/tail_de1.38553252
51MP0003091_abnormal_cell_migration1.38411239
52MP0006054_spinal_hemorrhage1.34942167
53MP0002116_abnormal_craniofacial_bone1.33962389
54MP0001542_abnormal_bone_strength1.31901795
55MP0002109_abnormal_limb_morphology1.28193607
56MP0000049_abnormal_middle_ear1.28105008
57MP0005248_abnormal_Harderian_gland1.26169386
58MP0006138_congestive_heart_failure1.25449846
59MP0003935_abnormal_craniofacial_develop1.23277055
60MP0002168_other_aberrant_phenotype1.21751837
61MP0005390_skeleton_phenotype1.21510442
62* MP0002113_abnormal_skeleton_development1.21415786
63MP0000432_abnormal_head_morphology1.20684010
64MP0000762_abnormal_tongue_morphology1.18216754
65MP0001440_abnormal_grooming_behavior1.16938303
66MP0002233_abnormal_nose_morphology1.15942792
67MP0002089_abnormal_postnatal_growth/wei1.14205664
68MP0000733_abnormal_muscle_development1.13298776
69MP0004858_abnormal_nervous_system1.10719494
70MP0000767_abnormal_smooth_muscle1.09405667
71MP0002177_abnormal_outer_ear1.09219097
72MP0003115_abnormal_respiratory_system1.07950470
73MP0001915_intracranial_hemorrhage1.05641105
74MP0002933_joint_inflammation1.05405138
75MP0003045_fibrosis1.04929309
76MP0003283_abnormal_digestive_organ1.02114974
77MP0003936_abnormal_reproductive_system1.01214743
78MP0010386_abnormal_urinary_bladder1.01079703
79MP0000613_abnormal_salivary_gland1.00302114
80MP0005389_reproductive_system_phenotype0.99398956
81MP0001346_abnormal_lacrimal_gland0.98999145
82MP0001177_atelectasis0.98932037
83MP0010368_abnormal_lymphatic_system0.98676460
84MP0000013_abnormal_adipose_tissue0.97271638
85MP0000639_abnormal_adrenal_gland0.96044544
86MP0000462_abnormal_digestive_system0.95227908
87MP0005409_darkened_coat_color0.94060718
88MP0002114_abnormal_axial_skeleton0.93171897
89MP0000537_abnormal_urethra_morphology0.92800831
90MP0009780_abnormal_chondrocyte_physiolo0.92712144
91MP0005171_absent_coat_pigmentation0.92067171
92MP0000579_abnormal_nail_morphology0.87809879
93MP0002111_abnormal_tail_morphology0.85980761
94MP0001293_anophthalmia0.85279605
95MP0002249_abnormal_larynx_morphology0.84491582
96MP0005595_abnormal_vascular_smooth0.83644597
97MP0002697_abnormal_eye_size0.83393762
98MP0003122_maternal_imprinting0.82055156
99MP0002102_abnormal_ear_morphology0.82024320
100MP0002998_abnormal_bone_remodeling0.82021362
101MP0000751_myopathy0.80877935
102MP0001661_extended_life_span0.79316345
103MP0001340_abnormal_eyelid_morphology0.78540599
104MP0005164_abnormal_response_to0.78184791
105MP0005375_adipose_tissue_phenotype0.76279096
106MP0003795_abnormal_bone_structure0.76259854
107MP0000759_abnormal_skeletal_muscle0.73309053
108MP0008004_abnormal_stomach_pH0.72146196
109MP0002876_abnormal_thyroid_physiology0.71060420
110MP0005220_abnormal_exocrine_pancreas0.70812357
111MP0001175_abnormal_lung_morphology0.70104725
112MP0001756_abnormal_urination0.69249891
113MP0005388_respiratory_system_phenotype0.67820302
114MP0002133_abnormal_respiratory_system0.67820302
115MP0000003_abnormal_adipose_tissue0.67495257
116MP0002092_abnormal_eye_morphology0.67182012
117MP0002128_abnormal_blood_circulation0.65743610
118MP0008775_abnormal_heart_ventricle0.64840158
119MP0009115_abnormal_fat_cell0.64649951
120MP0005076_abnormal_cell_differentiation0.64064725
121MP0002971_abnormal_brown_adipose0.63759184
122MP0004019_abnormal_vitamin_homeostasis0.63432960
123MP0003300_gastrointestinal_ulcer0.63352043
124MP0005193_abnormal_anterior_eye0.62827814
125MP0002075_abnormal_coat/hair_pigmentati0.62600699
126MP0002925_abnormal_cardiovascular_devel0.61490714
127MP0000230_abnormal_systemic_arterial0.61299902
128MP0005197_abnormal_uvea_morphology0.60201087
129MP0003453_abnormal_keratinocyte_physiol0.60144499
130MP0003448_altered_tumor_morphology0.59927464
131MP0001614_abnormal_blood_vessel0.58834989
132MP0000647_abnormal_sebaceous_gland0.57947794
133MP0000427_abnormal_hair_cycle0.53727743
134MP0004084_abnormal_cardiac_muscle0.52436376
135MP0000266_abnormal_heart_morphology0.52200170
136MP0000750_abnormal_muscle_regeneration0.51692703
137MP0002972_abnormal_cardiac_muscle0.50659049
138MP0001666_abnormal_nutrient_absorption0.49512898

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.88190859
2Premature rupture of membranes (HP:0001788)6.80453997
3Shallow orbits (HP:0000586)4.81619230
4Peritonitis (HP:0002586)4.64003255
5Arterial tortuosity (HP:0005116)4.62439386
6Aortic dissection (HP:0002647)4.39539413
7Broad metatarsal (HP:0001783)4.24069077
8Atrophic scars (HP:0001075)4.06524499
9Short 4th metacarpal (HP:0010044)3.83947983
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.83947983
11Soft skin (HP:0000977)3.80798906
12Aortic aneurysm (HP:0004942)3.79526144
13Neonatal short-limb short stature (HP:0008921)3.57908858
14Abnormality of the parietal bone (HP:0002696)3.56146449
15Abnormality of dentin (HP:0010299)3.55231175
16Bladder diverticulum (HP:0000015)3.50380822
17Capillary hemangiomas (HP:0005306)3.48052820
18Nonimmune hydrops fetalis (HP:0001790)3.45940691
19Infantile muscular hypotonia (HP:0008947)3.39872087
20Genu recurvatum (HP:0002816)3.37093386
21Disproportionate tall stature (HP:0001519)3.34755968
22Dilatation of the ascending aorta (HP:0005111)3.29444412
23Fragile skin (HP:0001030)3.28727059
24Mesomelia (HP:0003027)3.26617442
25Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.20376962
26Cervical subluxation (HP:0003308)3.10488124
27Ankle contracture (HP:0006466)3.04336047
28Upper limb muscle weakness (HP:0003484)2.94550706
29Wormian bones (HP:0002645)2.91047560
30Midline defect of the nose (HP:0004122)2.85369241
31Blue sclerae (HP:0000592)2.83832201
32Abnormality of the 4th metacarpal (HP:0010012)2.83332825
33Mitral valve prolapse (HP:0001634)2.82494015
34Bell-shaped thorax (HP:0001591)2.78528825
35Vitreoretinal degeneration (HP:0000655)2.75660501
36Bowel diverticulosis (HP:0005222)2.72210942
37Mitral stenosis (HP:0001718)2.71692904
38Hypoplasia of the iris (HP:0007676)2.68561526
39Hypoplastic ischia (HP:0003175)2.68475613
40Biconcave vertebral bodies (HP:0004586)2.67299349
41Cardiovascular calcification (HP:0011915)2.66643345
42Wide anterior fontanel (HP:0000260)2.64292411
43Hyperextensible skin (HP:0000974)2.63079332
44Vascular tortuosity (HP:0004948)2.61191955
45Follicular hyperkeratosis (HP:0007502)2.58971255
46Cerebral aneurysm (HP:0004944)2.57979283
47Venous insufficiency (HP:0005293)2.57588889
48Aortic regurgitation (HP:0001659)2.57429270
49Coronal craniosynostosis (HP:0004440)2.57033763
50Microglossia (HP:0000171)2.51896145
51Ectopia lentis (HP:0001083)2.48659265
52Hypergonadotropic hypogonadism (HP:0000815)2.46221153
53Broad long bones (HP:0005622)2.45221513
54Osteoarthritis (HP:0002758)2.41358497
55Long eyelashes (HP:0000527)2.40533727
56Aneurysm (HP:0002617)2.39231052
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39117028
58Abnormality of the distal phalanx of the thumb (HP:0009617)2.38812723
59Round ear (HP:0100830)2.35623134
60Aplasia involving bones of the extremities (HP:0009825)2.35514297
61Aplasia involving bones of the upper limbs (HP:0009823)2.35514297
62Aplasia of the phalanges of the hand (HP:0009802)2.35514297
63Trigonocephaly (HP:0000243)2.34594873
64Abnormality of the ischium (HP:0003174)2.34302320
65Abnormality of the nasal septum (HP:0000419)2.32958743
66Venous abnormality (HP:0002624)2.31855349
67Abnormality of the peritoneum (HP:0002585)2.29985433
68Osteolytic defects of the hand bones (HP:0009699)2.29512314
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.29512314
70Broad face (HP:0000283)2.29197078
71Flat cornea (HP:0007720)2.25792340
72Genu valgum (HP:0002857)2.25315160
73Deviation of the hallux (HP:0010051)2.25036148
74Wrist flexion contracture (HP:0001239)2.24536889
75Buphthalmos (HP:0000557)2.24318284
76Spinal rigidity (HP:0003306)2.24063978
77Long palpebral fissure (HP:0000637)2.23803088
78Overgrowth (HP:0001548)2.23529202
79Broad ribs (HP:0000885)2.23411830
80Slender build (HP:0001533)2.21344951
81Mild short stature (HP:0003502)2.20342301
82Delayed gross motor development (HP:0002194)2.19622814
83Back pain (HP:0003418)2.18489186
84Striae distensae (HP:0001065)2.17814777
85Decreased skull ossification (HP:0004331)2.17510134
86Vertebral compression fractures (HP:0002953)2.17388128
87Hallux valgus (HP:0001822)2.15892195
88Aortic valve stenosis (HP:0001650)2.15215006
89Exostoses (HP:0100777)2.13873006
90Arachnodactyly (HP:0001166)2.12377991
91Broad phalanx (HP:0006009)2.10337063
92Abnormality of the proximal phalanges of the hand (HP:0009834)2.09821361
93Cupped ribs (HP:0000887)2.08495234
94Pectus carinatum (HP:0000768)2.08107060
95Accelerated skeletal maturation (HP:0005616)2.07793895
96Inguinal hernia (HP:0000023)2.07391707
97Flat capital femoral epiphysis (HP:0003370)2.05764672
98Joint laxity (HP:0001388)2.05307279
99Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.04714038
100Abnormality of the acetabulum (HP:0003170)2.04672487
101Tibial bowing (HP:0002982)2.00980296
102Type 1 muscle fiber predominance (HP:0003803)2.00804534
103Broad toe (HP:0001837)2.00646875
104Abnormal delivery (HP:0001787)2.00514549
105Abnormality of incisor morphology (HP:0011063)1.95445486
106Morphological abnormality of the middle ear (HP:0008609)1.94978986
107Protruding ear (HP:0000411)1.94385929
108Mildly elevated creatine phosphokinase (HP:0008180)1.94151619
109Limited hip movement (HP:0008800)1.93760161
110Femoral bowing (HP:0002980)1.92886879
111Abnormal auditory evoked potentials (HP:0006958)1.92856713
112Hip contracture (HP:0003273)1.91978173
113Short nail (HP:0001799)1.91416327
114Abnormal ossification of hand bones (HP:0005921)1.89513407
115Elbow flexion contracture (HP:0002987)1.89335496
116Ulnar bowing (HP:0003031)1.89246974
117Congenital glaucoma (HP:0001087)1.88799954
118Thoracolumbar scoliosis (HP:0002944)1.88763323
119Abnormality of skull ossification (HP:0002703)1.87457124
120Spinal cord lesions (HP:0100561)1.87161242
121Syringomyelia (HP:0003396)1.87161242
122Thin bony cortex (HP:0002753)1.85311739
123Spondylolisthesis (HP:0003302)1.84326995
124Pulmonic stenosis (HP:0001642)1.82864372
125Abnormality of the middle phalanges of the hand (HP:0009833)1.82682420
126Mitral regurgitation (HP:0001653)1.82534293
127Knee flexion contracture (HP:0006380)1.81647804
128Spinal cord compression (HP:0002176)1.81425425
129Broad finger (HP:0001500)1.81353938
130Camptodactyly of toe (HP:0001836)1.79285969
131Abnormality of the anterior chamber (HP:0000593)1.79263046
132Increased variability in muscle fiber diameter (HP:0003557)1.78783590
133Broad hallux (HP:0010055)1.78297507
134Joint stiffness (HP:0001387)1.77884459
135Narrow palate (HP:0000189)1.76962563
136Hypoventilation (HP:0002791)1.75501256
137Epiphyseal dysplasia (HP:0002656)1.74144840
138Broad phalanges of the hand (HP:0009768)1.74113434
139Absent frontal sinuses (HP:0002688)1.73818510
140Ovoid vertebral bodies (HP:0003300)1.71140242
141Keratoconus (HP:0000563)1.70925591
142Increased corneal curvature (HP:0100692)1.70925591
143Platyspondyly (HP:0000926)1.68984489
144Kyphoscoliosis (HP:0002751)1.67895897
145Renal duplication (HP:0000075)1.63746251
146Abnormal pupillary function (HP:0007686)1.62087997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.18807707
2KDR5.47867644
3LATS14.73982365
4AKT34.49635439
5PDGFRA3.61506951
6LATS23.47667130
7EPHA33.10411664
8TTN2.86092617
9FGFR22.69521249
10EPHB22.65556427
11PIK3CA2.40695113
12SIK12.24825101
13PAK32.23417365
14PAK22.12494429
15STK38L2.08423332
16STK31.98539923
17DAPK21.97862628
18FER1.90667317
19NUAK11.83726110
20FGFR11.68286896
21RIPK11.65650263
22TRPM71.63328021
23PTK21.57045603
24PDGFRB1.51905002
25PTK2B1.47756454
26ERBB31.45197359
27TIE11.43249238
28TRIB31.43243199
29PLK21.43052481
30DMPK1.38442286
31RPS6KA21.36216284
32FLT31.35745600
33BMX1.33087672
34FRK1.26989816
35WNK11.25580676
36ROCK11.17430141
37MAP3K71.16620116
38MYLK1.13720367
39MTOR1.10193343
40CAMK1G1.08817446
41NTRK10.90886991
42CAMK1D0.90671426
43MET0.89797614
44CDC42BPA0.89711213
45MAPKAPK50.89333306
46EPHB10.87866893
47PIM20.82943168
48INSR0.81814354
49ERN10.78960181
50TESK10.77754153
51TGFBR20.75594991
52PIK3CG0.74196009
53PRKG20.73037120
54BLK0.69561471
55MELK0.68446454
56RPS6KC10.67352828
57RPS6KL10.67352828
58PDPK10.66993494
59LIMK10.66400355
60NLK0.65332082
61PRKD30.65294081
62EPHA20.62751150
63PRKCE0.62320257
64PRKCH0.62020693
65ADRBK10.61953150
66ZAK0.61146655
67PTK60.60101514
68RPS6KA60.58965617
69MOS0.58332115
70PKN10.57886609
71PKN20.56388156
72JAK10.55352811
73ROCK20.55186381
74EIF2AK20.51774217
75RET0.51493050
76PRKD10.49794639
77RPS6KA40.49105547
78STK240.49048375
79GRK50.48542161
80ARAF0.48504855
81DYRK1B0.47983703
82WNK40.47854927
83NEK90.47669525
84EGFR0.46517871
85PRKD20.46277839
86LMTK20.45058713
87SRC0.44162714
88MAPK40.44001336
89ERBB40.43650853
90MAP3K60.41331127
91CDK80.40548137
92STK390.39556643
93ILK0.39284654
94CLK10.39150650
95MAPK10.38981335
96KIT0.38953486
97IGF1R0.38879141
98CSNK1A1L0.38360669
99CDK120.38181385
100STK380.38097689
101MAP3K30.37910607
102CDK60.36745550
103ABL10.35409064
104BMPR1B0.33755835
105DAPK10.33523335
106MARK20.32188424
107PAK40.31906756
108FGFR30.30200194
109ERBB20.29813083
110MAPK70.28956392
111WNK30.28913191
112MAP3K120.28738895
113MAP2K10.28291974
114MKNK10.28086676
115CASK0.26081370
116DAPK30.26011061
117CAMK2G0.25709791
118PAK60.25649947
119FYN0.25558026
120IRAK10.24656152
121MAP3K90.23902469
122BCR0.23505872
123ABL20.23109188
124ICK0.22746113
125GSK3A0.22615255
126PRKG10.22231294
127TAOK20.21775325
128MAPK80.21682408
129CHUK0.21341869
130CAMK40.19765134
131JAK30.19704302
132INSRR0.19560897
133PNCK0.19402802
134AKT20.18919589
135TYK20.17599191
136PDK20.17425674
137MAPK110.16298249
138STK100.16181915

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.63447522
2Steroid hormone biosynthesis_Homo sapiens_hsa001403.98195940
3Basal cell carcinoma_Homo sapiens_hsa052173.32808846
4Hedgehog signaling pathway_Homo sapiens_hsa043403.09802406
5Focal adhesion_Homo sapiens_hsa045102.95659256
6Protein digestion and absorption_Homo sapiens_hsa049742.77249164
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.44054236
8TGF-beta signaling pathway_Homo sapiens_hsa043502.41315583
9Jak-STAT signaling pathway_Homo sapiens_hsa046302.34882315
10Proteoglycans in cancer_Homo sapiens_hsa052052.22218385
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.21664234
12Hippo signaling pathway_Homo sapiens_hsa043902.16794816
13Amoebiasis_Homo sapiens_hsa051462.10036792
14Melanoma_Homo sapiens_hsa052182.09675446
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04564434
16Dilated cardiomyopathy_Homo sapiens_hsa054141.99981025
17Adherens junction_Homo sapiens_hsa045201.97356151
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.94883791
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.85987927
20Wnt signaling pathway_Homo sapiens_hsa043101.84492000
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.82546769
22Malaria_Homo sapiens_hsa051441.80796820
23MicroRNAs in cancer_Homo sapiens_hsa052061.73024114
24Axon guidance_Homo sapiens_hsa043601.66947577
25N-Glycan biosynthesis_Homo sapiens_hsa005101.66577281
26Small cell lung cancer_Homo sapiens_hsa052221.62037212
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.55010540
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52905040
29Bladder cancer_Homo sapiens_hsa052191.46278885
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.46069014
31Pathways in cancer_Homo sapiens_hsa052001.45526020
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.39207840
33Prostate cancer_Homo sapiens_hsa052151.33835820
34Rap1 signaling pathway_Homo sapiens_hsa040151.26091936
35Sphingolipid metabolism_Homo sapiens_hsa006001.23012733
36Ovarian steroidogenesis_Homo sapiens_hsa049131.19662168
37Melanogenesis_Homo sapiens_hsa049161.19555533
38p53 signaling pathway_Homo sapiens_hsa041151.17454299
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15133342
40Chronic myeloid leukemia_Homo sapiens_hsa052201.07626101
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00939861
42Glioma_Homo sapiens_hsa052140.98481597
43Mineral absorption_Homo sapiens_hsa049780.98180204
44Ras signaling pathway_Homo sapiens_hsa040140.92781489
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91404561
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89123405
47Tight junction_Homo sapiens_hsa045300.88089531
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88032883
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85807495
50Folate biosynthesis_Homo sapiens_hsa007900.84871692
51Prion diseases_Homo sapiens_hsa050200.84215414
52HTLV-I infection_Homo sapiens_hsa051660.82874589
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.82394647
54Phagosome_Homo sapiens_hsa041450.82047499
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81099766
56Cocaine addiction_Homo sapiens_hsa050300.80895202
57Platelet activation_Homo sapiens_hsa046110.79398539
58Colorectal cancer_Homo sapiens_hsa052100.77495634
59Gap junction_Homo sapiens_hsa045400.76961894
60Pancreatic cancer_Homo sapiens_hsa052120.76883382
61MAPK signaling pathway_Homo sapiens_hsa040100.76482247
62Inositol phosphate metabolism_Homo sapiens_hsa005620.75994995
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.75713484
64Dorso-ventral axis formation_Homo sapiens_hsa043200.75045078
65Viral myocarditis_Homo sapiens_hsa054160.74701361
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73881271
67Prolactin signaling pathway_Homo sapiens_hsa049170.71275180
68TNF signaling pathway_Homo sapiens_hsa046680.70911381
69cAMP signaling pathway_Homo sapiens_hsa040240.70820514
70Other glycan degradation_Homo sapiens_hsa005110.68212281
71ErbB signaling pathway_Homo sapiens_hsa040120.67250606
72Shigellosis_Homo sapiens_hsa051310.66490865
73Complement and coagulation cascades_Homo sapiens_hsa046100.66203043
74Toxoplasmosis_Homo sapiens_hsa051450.65844011
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.64369222
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62600229
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62099386
78Estrogen signaling pathway_Homo sapiens_hsa049150.59415456
79Renal cell carcinoma_Homo sapiens_hsa052110.58480306
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57184676
81GnRH signaling pathway_Homo sapiens_hsa049120.56419297
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55374687
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55187356
84Thyroid hormone synthesis_Homo sapiens_hsa049180.54729200
85Lysine degradation_Homo sapiens_hsa003100.54267219
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53416596
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.51737620
88FoxO signaling pathway_Homo sapiens_hsa040680.51556769
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.51392194
90Salivary secretion_Homo sapiens_hsa049700.50176198
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45928945
92Salmonella infection_Homo sapiens_hsa051320.45220321
93Endometrial cancer_Homo sapiens_hsa052130.45170085
94Amphetamine addiction_Homo sapiens_hsa050310.44388887
95Hepatitis B_Homo sapiens_hsa051610.44278546
96Oxytocin signaling pathway_Homo sapiens_hsa049210.43820896
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43175321
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42191301
99Cholinergic synapse_Homo sapiens_hsa047250.41846728
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41395897
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41238832
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.41087845
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40305974
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40245960
105Insulin resistance_Homo sapiens_hsa049310.40144466
106Renin secretion_Homo sapiens_hsa049240.40078745
107Long-term depression_Homo sapiens_hsa047300.40027990
108Olfactory transduction_Homo sapiens_hsa047400.39061999
109Endocytosis_Homo sapiens_hsa041440.36804352
110Choline metabolism in cancer_Homo sapiens_hsa052310.36743342
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35945847
112Notch signaling pathway_Homo sapiens_hsa043300.35192082
113HIF-1 signaling pathway_Homo sapiens_hsa040660.34906824
114Steroid biosynthesis_Homo sapiens_hsa001000.34586551
115Pertussis_Homo sapiens_hsa051330.34178890
116African trypanosomiasis_Homo sapiens_hsa051430.33582051
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33334675
118AMPK signaling pathway_Homo sapiens_hsa041520.33043332
119Vibrio cholerae infection_Homo sapiens_hsa051100.32976138
120Renin-angiotensin system_Homo sapiens_hsa046140.32724866
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31827145
122Circadian entrainment_Homo sapiens_hsa047130.29792453
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29321997
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.28271236
125Viral carcinogenesis_Homo sapiens_hsa052030.27149284

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