PAPPA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.12748785
2Golgi transport vesicle coating (GO:0048200)9.12748785
3androgen biosynthetic process (GO:0006702)8.45134733
4multi-multicellular organism process (GO:0044706)7.81251082
5androgen metabolic process (GO:0008209)7.57372081
6multi-organism reproductive process (GO:0044703)6.76846617
7positive regulation of growth hormone secretion (GO:0060124)6.33718400
8type B pancreatic cell development (GO:0003323)6.22501777
9peptide hormone processing (GO:0016486)6.07785193
10glucocorticoid metabolic process (GO:0008211)5.90040231
11hormone biosynthetic process (GO:0042446)5.81675170
12cellular response to vitamin D (GO:0071305)5.72422615
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.66735113
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.55263715
15COPII vesicle coating (GO:0048208)5.48300489
16L-alpha-amino acid transmembrane transport (GO:1902475)5.44390198
17glandular epithelial cell development (GO:0002068)5.44104840
18negative regulation of activin receptor signaling pathway (GO:0032926)5.36758643
19endocrine pancreas development (GO:0031018)5.20968961
20response to gonadotropin (GO:0034698)5.04452101
21glandular epithelial cell differentiation (GO:0002067)5.04223724
22protein retention in ER lumen (GO:0006621)4.94606571
23activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.86047713
24negative regulation of JUN kinase activity (GO:0043508)4.68375852
25protein maturation by protein folding (GO:0022417)4.64656446
26positive regulation of nuclease activity (GO:0032075)4.59700976
27vitamin transmembrane transport (GO:0035461)4.53347721
28myoblast fusion (GO:0007520)4.53039377
29vesicle coating (GO:0006901)4.43876709
30collecting duct development (GO:0072044)4.38915780
31regulation of growth hormone secretion (GO:0060123)4.33058424
32myelin maintenance (GO:0043217)4.31102251
33positive regulation of insulin secretion (GO:0032024)4.29486174
34endocrine hormone secretion (GO:0060986)4.28769906
35positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.26974922
36columnar/cuboidal epithelial cell development (GO:0002066)4.25812554
37insulin secretion (GO:0030073)4.18336438
38regulation of nuclease activity (GO:0032069)4.16075415
39syncytium formation (GO:0006949)4.15390319
40sphingoid metabolic process (GO:0046519)4.09959520
41positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.04789990
42exocrine pancreas development (GO:0031017)4.02991722
43sequestering of metal ion (GO:0051238)4.02567517
44cellular response to vitamin (GO:0071295)3.97202369
45JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.94424778
46endoplasmic reticulum unfolded protein response (GO:0030968)3.92364279
47syncytium formation by plasma membrane fusion (GO:0000768)3.88212161
48cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.86087584
49sequestering of extracellular ligand from receptor (GO:0035581)3.82058981
50cellular response to unfolded protein (GO:0034620)3.80189535
51regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.77046326
52toxin metabolic process (GO:0009404)3.74724922
53keratinocyte development (GO:0003334)3.74654125
54positive regulation of protein kinase C signaling (GO:0090037)3.66177797
55regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.64312616
56endocrine process (GO:0050886)3.64312616
57regulation of systemic arterial blood pressure by hormone (GO:0001990)3.64312616
58regulation of type B pancreatic cell apoptotic process (GO:2000674)3.63743132
59protein neddylation (GO:0045116)3.62339298
60ER-nucleus signaling pathway (GO:0006984)3.62155356
61epithelial cell fate commitment (GO:0072148)3.60281969
62cellular response to topologically incorrect protein (GO:0035967)3.60116847
63cellular response to hepatocyte growth factor stimulus (GO:0035729)3.59463027
64response to hepatocyte growth factor (GO:0035728)3.59463027
65detection of calcium ion (GO:0005513)3.57578774
66regulation of insulin secretion (GO:0050796)3.55953946
67lymphangiogenesis (GO:0001946)3.47914878
68peptide hormone secretion (GO:0030072)3.46035800
69positive regulation of hormone biosynthetic process (GO:0046886)3.43730881
70positive regulation of peptide hormone secretion (GO:0090277)3.40719133
71peptide secretion (GO:0002790)3.39523201
72parturition (GO:0007567)3.32132604
73ER overload response (GO:0006983)3.30375014
74inner ear receptor cell development (GO:0060119)3.29494620
75intra-Golgi vesicle-mediated transport (GO:0006891)3.28543674
76cellular hormone metabolic process (GO:0034754)3.27974707
77positive regulation of peptide secretion (GO:0002793)3.27286879
78negative regulation of glycogen biosynthetic process (GO:0045719)3.26732345
79inositol phosphate-mediated signaling (GO:0048016)3.23641867
80protein N-linked glycosylation via asparagine (GO:0018279)3.22741477
81positive regulation of calcium ion import (GO:0090280)3.21654612
82peptidyl-asparagine modification (GO:0018196)3.20800180
83regulation of peptide hormone secretion (GO:0090276)3.19959212
84negative regulation of catenin import into nucleus (GO:0035414)3.19503611
85gland morphogenesis (GO:0022612)3.17471309
86negative regulation of digestive system process (GO:0060457)3.16514111
87glomerulus development (GO:0032835)3.16131028
88regulation of uterine smooth muscle contraction (GO:0070472)3.15864827
89positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.14167668
90regulation of peptide secretion (GO:0002791)3.13281084
91ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.13235011
92response to endoplasmic reticulum stress (GO:0034976)3.12028356
93convergent extension (GO:0060026)3.11220232
94Golgi organization (GO:0007030)3.09588810
95inositol phosphate dephosphorylation (GO:0046855)3.09455775
96phosphorylated carbohydrate dephosphorylation (GO:0046838)3.09455775
97inositol phosphate catabolic process (GO:0071545)3.08298095
98regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.06969618
99positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05581652
100macroautophagy (GO:0016236)3.04877780
101nitric oxide biosynthetic process (GO:0006809)3.04456120
102response to lipoprotein particle (GO:0055094)3.03948893
103negative regulation of norepinephrine secretion (GO:0010700)3.01909415
104estrogen biosynthetic process (GO:0006703)24.6273814
105ER to Golgi vesicle-mediated transport (GO:0006888)2.99250745
106artery smooth muscle contraction (GO:0014824)2.98721108
107regulation of norepinephrine secretion (GO:0014061)2.98686689
108negative regulation of execution phase of apoptosis (GO:1900118)2.97780097
109nitric oxide mediated signal transduction (GO:0007263)2.95802166
110signal peptide processing (GO:0006465)2.95658579
111growth hormone secretion (GO:0030252)2.95543183
112UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95454921
113cellular response to glucagon stimulus (GO:0071377)2.94372508
114regulation of extracellular matrix disassembly (GO:0010715)2.93838063
115protein N-linked glycosylation (GO:0006487)2.93134913
116vascular endothelial growth factor signaling pathway (GO:0038084)2.92831650
117positive regulation of hormone secretion (GO:0046887)2.91369041
118hormone metabolic process (GO:0042445)2.90522362
119regulation of penile erection (GO:0060405)2.89974867
120dorsal/ventral axis specification (GO:0009950)2.88284964
121protein autoprocessing (GO:0016540)2.87080476
122cellular zinc ion homeostasis (GO:0006882)2.86562177
123regulation of glucose import in response to insulin stimulus (GO:2001273)2.85764059
124response to unfolded protein (GO:0006986)2.84605660
125regulation of calcium ion-dependent exocytosis (GO:0017158)2.83347679
126regulation of hormone secretion (GO:0046883)2.83298356
127protein targeting to Golgi (GO:0000042)2.83267121
128astrocyte differentiation (GO:0048708)2.83010111
129regulation of non-canonical Wnt signaling pathway (GO:2000050)2.82619555
130chemosensory behavior (GO:0007635)2.78198826
131negative regulation of complement activation (GO:0045916)2.77838236
132regulation of systemic arterial blood pressure (GO:0003073)2.76283885
133membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.75714114
134negative regulation of osteoblast proliferation (GO:0033689)2.73246714
135establishment of protein localization to Golgi (GO:0072600)2.72157211
136response to topologically incorrect protein (GO:0035966)2.70420164
137negative regulation of glycogen metabolic process (GO:0070874)2.70370635
138vitamin D metabolic process (GO:0042359)2.70221645
139response to ischemia (GO:0002931)2.69586240
140intestinal epithelial cell development (GO:0060576)2.69374498
141hormone secretion (GO:0046879)2.68775279
142Sertoli cell development (GO:0060009)2.68042479
143transcytosis (GO:0045056)2.67607314
144positive regulation of vesicle fusion (GO:0031340)2.67208303
145interkinetic nuclear migration (GO:0022027)2.65240173
146regulation of endocrine process (GO:0044060)2.62486911
147regulation of interferon-gamma biosynthetic process (GO:0045072)2.59530680
148retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57987933
149phenylpropanoid metabolic process (GO:0009698)2.56949068
150Leydig cell differentiation (GO:0033327)2.56876765
151steroid biosynthetic process (GO:0006694)2.55012024
152positive regulation of gluconeogenesis (GO:0045722)2.52855045
153regulation of hormone levels (GO:0010817)2.52113537
154regulation of protein kinase C signaling (GO:0090036)2.49099129
155positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.47343832
156negative regulation of protein activation cascade (GO:2000258)2.45101624
157sphingosine metabolic process (GO:0006670)2.45013806
158iron ion import (GO:0097286)2.44941607
159extracellular regulation of signal transduction (GO:1900115)2.44018922
160extracellular negative regulation of signal transduction (GO:1900116)2.44018922
161protein localization to Golgi apparatus (GO:0034067)2.42475366
162positive regulation of macroautophagy (GO:0016239)2.39089819
163positive regulation of histone H3-K4 methylation (GO:0051571)2.38217711
164glycerophospholipid catabolic process (GO:0046475)2.32198109
165sphingomyelin metabolic process (GO:0006684)2.31788434
166phospholipid dephosphorylation (GO:0046839)2.28154317
167oligosaccharide catabolic process (GO:0009313)2.25384769
168sprouting angiogenesis (GO:0002040)2.24871954
169diacylglycerol metabolic process (GO:0046339)2.23502141
170regulation of clathrin-mediated endocytosis (GO:2000369)2.23384185
171JAK-STAT cascade (GO:0007259)2.23134096
172regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.22161729
173polyol catabolic process (GO:0046174)2.21955820
174ovulation from ovarian follicle (GO:0001542)2.20600875
175thyroid hormone metabolic process (GO:0042403)2.17959726
176T-helper 1 type immune response (GO:0042088)2.17500214
177nodal signaling pathway (GO:0038092)2.16408906
178diol metabolic process (GO:0034311)2.15487371
179cellular response to gonadotropin stimulus (GO:0071371)2.14689863
180positive regulation of digestive system process (GO:0060456)2.13472845
181response to follicle-stimulating hormone (GO:0032354)11.4772023
182estrogen metabolic process (GO:0008210)11.1457537
183regulation of gonadotropin secretion (GO:0032276)10.9053292
184prostate gland growth (GO:0060736)10.8519390
185female pregnancy (GO:0007565)10.5384795
186glucocorticoid biosynthetic process (GO:0006704)10.0136290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.20984613
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human6.75541032
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90447402
4GATA1_22025678_ChIP-Seq_K562_Human2.76531753
5EGR1_19032775_ChIP-ChIP_M12_Human2.46844681
6IGF1R_20145208_ChIP-Seq_DFB_Human2.27031914
7ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.18106872
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12020467
9* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.06562899
10ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94109677
11STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89492547
12TP53_18474530_ChIP-ChIP_U2OS_Human1.87877310
13TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.87489382
14NR3C1_23031785_ChIP-Seq_PC12_Mouse1.80992115
15FUS_26573619_Chip-Seq_HEK293_Human1.80889108
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80811561
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76110587
18TAF15_26573619_Chip-Seq_HEK293_Human1.75674602
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.75654953
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.73566826
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.73434431
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.71041461
23HTT_18923047_ChIP-ChIP_STHdh_Human1.68144126
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56261006
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54100234
26* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53754786
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.53255735
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52267524
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50453982
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49449234
31CBP_20019798_ChIP-Seq_JUKART_Human1.49449234
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47450176
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46390560
34ER_23166858_ChIP-Seq_MCF-7_Human1.45806003
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.44177410
36STAT3_23295773_ChIP-Seq_U87_Human1.43745931
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43528461
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43375445
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42891018
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.42807312
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42540631
42BRD4_25478319_ChIP-Seq_HGPS_Human1.41983229
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40170615
44EWS_26573619_Chip-Seq_HEK293_Human1.39887547
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39815533
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39787354
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.39658356
48ZNF274_21170338_ChIP-Seq_K562_Hela1.38779728
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.37797287
50GBX2_23144817_ChIP-Seq_PC3_Human1.33525474
51YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32523432
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32046695
53WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31803224
54SMAD3_21741376_ChIP-Seq_HESCs_Human1.29812494
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.29285794
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28289163
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28186495
58AR_25329375_ChIP-Seq_VCAP_Human1.28183556
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28089082
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.26608151
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26441419
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26173521
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26171651
64RUNX2_22187159_ChIP-Seq_PCA_Human1.26155641
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26070570
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.26051109
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25307482
68CJUN_26792858_Chip-Seq_BT549_Human1.24056477
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23048341
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21845473
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21513382
72* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21108892
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20856489
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20745055
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20155465
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.20130741
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18707431
78FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.18019010
79SOX2_19829295_ChIP-Seq_ESCs_Human1.18000848
80NANOG_19829295_ChIP-Seq_ESCs_Human1.18000848
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16948467
82GATA3_24758297_ChIP-Seq_MCF-7_Human1.16506643
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15495050
84BCAT_22108803_ChIP-Seq_LS180_Human1.14486885
85JUN_21703547_ChIP-Seq_K562_Human1.14024177
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.13936779
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13489249
88AHR_22903824_ChIP-Seq_MCF-7_Human1.12989803
89GATA1_19941826_ChIP-Seq_K562_Human1.12854891
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.12632634
91* AR_19668381_ChIP-Seq_PC3_Human1.12629319
92CDX2_22108803_ChIP-Seq_LS180_Human1.12582586
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.11229371
94* FOXA1_25329375_ChIP-Seq_VCAP_Human1.11158098
95* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11158098
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10739851
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10355341
98* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10128411
99REST_21632747_ChIP-Seq_MESCs_Mouse1.09623392
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09539842
101* TP63_23658742_ChIP-Seq_EP156T_Human1.09462439
102FOXA2_19822575_ChIP-Seq_HepG2_Human1.09286417
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09137530
104JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08925546
105ERG_20517297_ChIP-Seq_VCAP_Human1.08502199
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08354152
107FOXA1_25552417_ChIP-Seq_VCAP_Human1.08330505
108* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08009346
109IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07881983
110* SMAD3_21741376_ChIP-Seq_EPCs_Human1.07346170
111* NANOG_18555785_Chip-Seq_ESCs_Mouse1.06304510
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.06282345
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06089136
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05138635
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05104577
116VDR_22108803_ChIP-Seq_LS180_Human1.03494301
117PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02842642
118TCF4_23295773_ChIP-Seq_U87_Human1.02214000
119* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01836027
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01330054
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00843081
122TAL1_26923725_Chip-Seq_HPCs_Mouse0.99981902
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99680925
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97579729
125DROSHA_22980978_ChIP-Seq_HELA_Human0.97113013
126TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97020028
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96771237
128SOX2_20726797_ChIP-Seq_SW620_Human0.96019410
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95940202
130RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95906475
131EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95906475
132* TBL1_22424771_ChIP-Seq_293T_Human0.95587857
133TP63_19390658_ChIP-ChIP_HaCaT_Human0.93972559
134GF1B_26923725_Chip-Seq_HPCs_Mouse0.93717676
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93537118
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.92123360
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92036293
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.91241788
139P300_19829295_ChIP-Seq_ESCs_Human0.90147081
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90095238
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90095238
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89875789
143JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89401691
144GF1_26923725_Chip-Seq_HPCs_Mouse0.89196049
145REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88113424
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87901603
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86099548
148EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85875793
149TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85362989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation8.06202817
2MP0000013_abnormal_adipose_tissue5.50099205
3MP0002877_abnormal_melanocyte_morpholog4.27854582
4MP0002909_abnormal_adrenal_gland3.67598580
5MP0003283_abnormal_digestive_organ3.66831123
6MP0003195_calcinosis3.63872113
7MP0005379_endocrine/exocrine_gland_phen3.57475528
8MP0001944_abnormal_pancreas_morphology3.56532462
9MP0003183_abnormal_peptide_metabolism3.56105904
10MP0006276_abnormal_autonomic_nervous3.50579287
11MP0002693_abnormal_pancreas_physiology3.44626579
12MP0000003_abnormal_adipose_tissue3.22653678
13MP0005647_abnormal_sex_gland3.00077118
14MP0009780_abnormal_chondrocyte_physiolo2.91479948
15MP0000678_abnormal_parathyroid_gland2.89092338
16MP0003122_maternal_imprinting2.86736606
17MP0002876_abnormal_thyroid_physiology2.83687729
18MP0004019_abnormal_vitamin_homeostasis2.71137278
19MP0001919_abnormal_reproductive_system2.65737076
20MP0005220_abnormal_exocrine_pancreas2.47123625
21MP0006054_spinal_hemorrhage2.37264569
22MP0002837_dystrophic_cardiac_calcinosis2.28798675
23MP0005645_abnormal_hypothalamus_physiol2.27110926
24MP0002896_abnormal_bone_mineralization2.25133675
25MP0004264_abnormal_extraembryonic_tissu2.24499105
26MP0002139_abnormal_hepatobiliary_system2.20697590
27MP0005187_abnormal_penis_morphology2.19844872
28MP0010386_abnormal_urinary_bladder2.10516363
29MP0010368_abnormal_lymphatic_system2.09648298
30MP0010329_abnormal_lipoprotein_level2.06656818
31MP0004043_abnormal_pH_regulation2.06543151
32MP0001299_abnormal_eye_distance/2.01251432
33MP0002234_abnormal_pharynx_morphology2.00419336
34MP0002078_abnormal_glucose_homeostasis1.85549963
35MP0005257_abnormal_intraocular_pressure1.78291861
36MP0005389_reproductive_system_phenotype1.77810946
37MP0001440_abnormal_grooming_behavior1.71435370
38MP0003300_gastrointestinal_ulcer1.66775363
39MP0002938_white_spotting1.66287856
40MP0004272_abnormal_basement_membrane1.62620302
41MP0001986_abnormal_taste_sensitivity1.61229862
42MP0000462_abnormal_digestive_system1.58536666
43MP0009384_cardiac_valve_regurgitation1.54196157
44MP0005375_adipose_tissue_phenotype1.48842893
45MP0000639_abnormal_adrenal_gland1.47143427
46MP0003959_abnormal_lean_body1.46655012
47MP0000428_abnormal_craniofacial_morphol1.45648895
48MP0002971_abnormal_brown_adipose1.39099359
49MP0001765_abnormal_ion_homeostasis1.37204865
50MP0001661_extended_life_span1.34888638
51MP0003121_genomic_imprinting1.33605502
52MP0003941_abnormal_skin_development1.33572544
53MP0003787_abnormal_imprinting1.32771494
54MP0000613_abnormal_salivary_gland1.30384839
55MP0005248_abnormal_Harderian_gland1.28942055
56MP0002254_reproductive_system_inflammat1.27627523
57MP0009115_abnormal_fat_cell1.23893923
58MP0010352_gastrointestinal_tract_polyps1.22404815
59MP0004270_analgesia1.19603036
60MP0003252_abnormal_bile_duct1.18793803
61MP0001756_abnormal_urination1.18429758
62MP0003868_abnormal_feces_composition1.18028828
63MP0005503_abnormal_tendon_morphology1.17051722
64MP0002653_abnormal_ependyma_morphology1.16759985
65MP0003123_paternal_imprinting1.14442341
66MP0003172_abnormal_lysosome_physiology1.14329628
67MP0003045_fibrosis1.14221737
68MP0002557_abnormal_social/conspecific_i1.11299198
69MP0004085_abnormal_heartbeat1.10012745
70MP0003942_abnormal_urinary_system1.08996042
71MP0001270_distended_abdomen1.08795693
72MP0003119_abnormal_digestive_system1.08587431
73MP0000647_abnormal_sebaceous_gland1.07453788
74MP0008961_abnormal_basal_metabolism1.06078031
75MP0002168_other_aberrant_phenotype1.05751796
76MP0006072_abnormal_retinal_apoptosis1.05598227
77MP0003936_abnormal_reproductive_system1.05310683
78MP0000631_abnormal_neuroendocrine_gland1.05038154
79MP0003953_abnormal_hormone_level1.02783984
80MP0000516_abnormal_urinary_system1.02068227
81MP0005367_renal/urinary_system_phenotyp1.02068227
82MP0008877_abnormal_DNA_methylation1.00401434
83MP0002177_abnormal_outer_ear0.99393855
84MP0002163_abnormal_gland_morphology0.97765356
85MP0002075_abnormal_coat/hair_pigmentati0.95477165
86MP0004145_abnormal_muscle_electrophysio0.91327334
87MP0002638_abnormal_pupillary_reflex0.91050510
88MP0002928_abnormal_bile_duct0.90766283
89MP0000163_abnormal_cartilage_morphology0.90585623
90MP0002108_abnormal_muscle_morphology0.89514781
91MP0005076_abnormal_cell_differentiation0.87411574
92MP0004484_altered_response_of0.84799903
93MP0005670_abnormal_white_adipose0.82964535
94MP0003935_abnormal_craniofacial_develop0.82573994
95MP0004215_abnormal_myocardial_fiber0.81278404
96MP0009643_abnormal_urine_homeostasis0.80708089
97MP0004185_abnormal_adipocyte_glucose0.79370935
98MP0006138_congestive_heart_failure0.79130932
99MP0005508_abnormal_skeleton_morphology0.78528770
100MP0002972_abnormal_cardiac_muscle0.76358421
101MP0005452_abnormal_adipose_tissue0.75428214
102MP0000230_abnormal_systemic_arterial0.75169873
103MP0000427_abnormal_hair_cycle0.74868498
104MP0010678_abnormal_skin_adnexa0.73185090
105MP0002116_abnormal_craniofacial_bone0.71992481
106MP0001501_abnormal_sleep_pattern0.71246722
107MP0005332_abnormal_amino_acid0.70630807
108MP0005365_abnormal_bile_salt0.70005302
109MP0001879_abnormal_lymphatic_vessel0.69108807
110MP0001346_abnormal_lacrimal_gland0.67091182
111MP0009703_decreased_birth_body0.65397373
112MP0001186_pigmentation_phenotype0.64103889
113MP0002295_abnormal_pulmonary_circulatio0.63780263
114MP0004885_abnormal_endolymph0.63229856
115MP0002751_abnormal_autonomic_nervous0.63194392
116MP0005448_abnormal_energy_balance0.63075917
117MP0002009_preneoplasia0.62405817
118MP0000372_irregular_coat_pigmentation0.62401293
119MP0005646_abnormal_pituitary_gland0.60076720
120MP0010234_abnormal_vibrissa_follicle0.59846819
121MP0000537_abnormal_urethra_morphology0.59269949
122MP0000534_abnormal_ureter_morphology0.59049633
123MP0003566_abnormal_cell_adhesion0.58881596
124MP0003795_abnormal_bone_structure0.58832085
125MP0002115_abnormal_skeleton_extremities0.58798672
126MP0002998_abnormal_bone_remodeling0.58555195
127MP0005319_abnormal_enzyme/_coenzyme0.57945762
128MP0002118_abnormal_lipid_homeostasis0.56255886
129MP0002138_abnormal_hepatobiliary_system0.55460965
130MP0005165_increased_susceptibility_to0.55442655
131MP0004134_abnormal_chest_morphology0.54524592
132MP0009046_muscle_twitch0.54110645
133MP0005409_darkened_coat_color0.53171269
134MP0001293_anophthalmia0.52971730
135MP0005058_abnormal_lysosome_morphology0.52752559
136MP0005334_abnormal_fat_pad0.52694414
137MP0000538_abnormal_urinary_bladder0.51970122
138MP0000579_abnormal_nail_morphology0.51626144
139MP0009672_abnormal_birth_weight0.51284164
140MP0001666_abnormal_nutrient_absorption0.50967019
141MP0005636_abnormal_mineral_homeostasis0.50694030
142MP0008775_abnormal_heart_ventricle0.50051442
143MP0004147_increased_porphyrin_level0.49802081
144MP0005535_abnormal_body_temperature0.49209078
145MP0005084_abnormal_gallbladder_morpholo0.48973086
146MP0000367_abnormal_coat/_hair0.44076719
147MP0000383_abnormal_hair_follicle0.43966381
148MP0002210_abnormal_sex_determination0.43964650
149MP0005174_abnormal_tail_pigmentation0.42189535
150MP0004133_heterotaxia0.41492306
151MP0005023_abnormal_wound_healing0.41391619
152MP0002572_abnormal_emotion/affect_behav0.39887568

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.82917950
2Hyperinsulinemic hypoglycemia (HP:0000825)7.25005031
3Hypoglycemic seizures (HP:0002173)6.07170524
4Hypergonadotropic hypogonadism (HP:0000815)6.03594139
5Pancreatic islet-cell hyperplasia (HP:0004510)5.50339312
6Hyperglycemia (HP:0003074)5.35699049
7Symptomatic seizures (HP:0011145)5.33854174
8Insulin-resistant diabetes mellitus (HP:0000831)5.30618106
9Tongue fasciculations (HP:0001308)5.29484630
10Upper limb muscle weakness (HP:0003484)5.21604802
11Muscle fibrillation (HP:0010546)5.13772205
12Capillary hemangiomas (HP:0005306)5.04068222
13Abnormality of calcium-phosphate metabolism (HP:0100530)5.01578098
14Mesangial abnormality (HP:0001966)4.92362989
15Hypoglycemic coma (HP:0001325)4.86326463
16Abnormality of the pancreatic islet cells (HP:0006476)4.85785998
17Abnormality of endocrine pancreas physiology (HP:0012093)4.85785998
18Large for gestational age (HP:0001520)4.68371770
19Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.52270315
20Abnormal pupillary function (HP:0007686)4.45158230
21Proximal tubulopathy (HP:0000114)4.23633587
22Accelerated skeletal maturation (HP:0005616)3.66112111
23Ketoacidosis (HP:0001993)3.64024119
24Cardiovascular calcification (HP:0011915)3.61800870
25Female pseudohermaphroditism (HP:0010458)3.55952602
26Abnormal albumin level (HP:0012116)3.55124897
27Hypoalbuminemia (HP:0003073)3.55124897
28Vascular calcification (HP:0004934)3.49110278
29Intestinal atresia (HP:0011100)3.48064511
30Double outlet right ventricle (HP:0001719)3.43882282
31Congenital malformation of the right heart (HP:0011723)3.43882282
32Testicular neoplasm (HP:0010788)3.42523029
33Hematochezia (HP:0002573)3.41819877
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.36412153
35Nonimmune hydrops fetalis (HP:0001790)3.34037627
36Agitation (HP:0000713)3.32671896
37Abnormal pancreas size (HP:0012094)3.29844731
38Abnormal auditory evoked potentials (HP:0006958)3.20380311
39Late onset (HP:0003584)3.16564110
40Hyperparathyroidism (HP:0000843)3.13323944
41Anosmia (HP:0000458)3.10394919
42Mucopolysacchariduria (HP:0008155)3.08099821
43Urinary glycosaminoglycan excretion (HP:0003541)3.08099821
44Anteriorly placed anus (HP:0001545)3.03217816
45Retinal atrophy (HP:0001105)3.02781969
46Turricephaly (HP:0000262)2.94026438
47Papilledema (HP:0001085)2.90584384
48Unilateral renal agenesis (HP:0000122)2.90129741
49Hypokalemia (HP:0002900)2.86451220
50Abnormality of polysaccharide metabolism (HP:0011012)2.86295946
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86295946
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86295946
53Dysostosis multiplex (HP:0000943)2.85381970
54Abnormality of vitamin B metabolism (HP:0004340)2.84077060
55Hyperphosphatemia (HP:0002905)2.80063950
56Prominent metopic ridge (HP:0005487)2.77748581
57Delayed gross motor development (HP:0002194)2.77081081
58Abnormality of the metopic suture (HP:0005556)2.75755788
59Hypogonadotrophic hypogonadism (HP:0000044)2.74511415
60Lower limb asymmetry (HP:0100559)2.72196608
61Abnormality of vitamin metabolism (HP:0100508)2.71129149
62Vacuolated lymphocytes (HP:0001922)2.70976522
63Macroorchidism (HP:0000053)2.70634833
64Abnormal sex determination (HP:0012244)2.69933016
65Sex reversal (HP:0012245)2.69933016
66Decreased circulating renin level (HP:0003351)2.68861914
67Osteomalacia (HP:0002749)2.67179237
68Hemiparesis (HP:0001269)2.61889290
69Broad face (HP:0000283)2.59952753
70Insulin resistance (HP:0000855)2.55501779
71Neoplasm of the heart (HP:0100544)2.52063697
72Increased circulating renin level (HP:0000848)2.51782170
73Abnormality of the parietal bone (HP:0002696)2.47092958
74Gynecomastia (HP:0000771)2.46031388
75Congenital glaucoma (HP:0001087)2.44171048
76Hypoplastic labia majora (HP:0000059)2.43894899
77Abnormality of potassium homeostasis (HP:0011042)2.39866638
78Abnormality of liposaccharide metabolism (HP:0010968)2.39317708
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.39317708
80Abnormality of glycolipid metabolism (HP:0010969)2.39317708
81Abnormality of the renal cortex (HP:0011035)2.39216149
82Focal segmental glomerulosclerosis (HP:0000097)2.38547026
83Hypsarrhythmia (HP:0002521)2.35951144
84EEG with generalized epileptiform discharges (HP:0011198)2.34693694
85Abnormality of the intrinsic pathway (HP:0010989)2.32783997
86Renal cortical cysts (HP:0000803)2.31532710
87Back pain (HP:0003418)2.29613263
88Glycosuria (HP:0003076)2.28580613
89Abnormality of urine glucose concentration (HP:0011016)2.28580613
90Exostoses (HP:0100777)2.27419239
91Abnormality of renin-angiotensin system (HP:0000847)2.25894748
92Menstrual irregularities (HP:0000858)2.25519777
93Midline defect of the nose (HP:0004122)2.25338732
94Dysautonomia (HP:0002459)2.25176218
95Conjugated hyperbilirubinemia (HP:0002908)2.23064568
96Epileptiform EEG discharges (HP:0011182)2.22873297
97Bronchomalacia (HP:0002780)2.22846464
98Enlarged penis (HP:0000040)2.21837463
99Bicornuate uterus (HP:0000813)2.21811890
100Methylmalonic acidemia (HP:0002912)2.21750067
101Hyperaldosteronism (HP:0000859)2.19552939
102Postural tremor (HP:0002174)2.17136090
103Abnormality of the labia majora (HP:0012881)2.15369743
104Alacrima (HP:0000522)2.11545518
105Tubular atrophy (HP:0000092)2.09522527
106Flat capital femoral epiphysis (HP:0003370)2.09510583
107Episodic fever (HP:0001954)2.09381840
108Conjunctival hamartoma (HP:0100780)2.08805008
109Bilateral microphthalmos (HP:0007633)2.07498828
110Progressive cerebellar ataxia (HP:0002073)2.05631265
111Hypoplasia of the uterus (HP:0000013)2.05009761
112Hamartoma of the eye (HP:0010568)2.04348096
113Aplasia/Hypoplasia of the tibia (HP:0005772)2.02847977
114Short tibia (HP:0005736)2.00052874
115Progressive neurologic deterioration (HP:0002344)1.98568635
116Cervical subluxation (HP:0003308)1.97285813
117Hepatoblastoma (HP:0002884)1.94137543
118Venous insufficiency (HP:0005293)1.92032192
119Abnormality of the diencephalon (HP:0010662)1.91690445
120Hypoventilation (HP:0002791)1.91629313
121Palpitations (HP:0001962)1.90907197
122Truncus arteriosus (HP:0001660)1.90757301
123Hyperthyroidism (HP:0000836)1.89846804
124Restlessness (HP:0000711)1.89069733
125Congenital cataract (HP:0000519)1.87918759
126Hypercortisolism (HP:0001578)1.87798800
127Exocrine pancreatic insufficiency (HP:0001738)1.87581973
128Hyperkalemia (HP:0002153)1.87410474
129Thoracolumbar scoliosis (HP:0002944)1.86915737
130Abdominal distention (HP:0003270)1.85169473
131Hypotension (HP:0002615)1.85051285
132Abnormality of the aortic arch (HP:0012303)1.84546539
133Generalized aminoaciduria (HP:0002909)1.84228810
134Hypophosphatemia (HP:0002148)1.83211984
135Shallow orbits (HP:0000586)1.82932866
136Abnormality of the common coagulation pathway (HP:0010990)1.79820454
137White forelock (HP:0002211)1.79794065
138Aplasia/hypoplasia of the uterus (HP:0008684)1.79267523
139Stage 5 chronic kidney disease (HP:0003774)1.78006088
140Abnormality of the pupil (HP:0000615)1.76584021
141Blue irides (HP:0000635)1.75724114
142Toxemia of pregnancy (HP:0100603)1.75176192
143Severe short stature (HP:0003510)1.72149311
144Abnormal rod and cone electroretinograms (HP:0008323)1.71981450
145Trigonocephaly (HP:0000243)1.71321772
146Orthostatic hypotension (HP:0001278)1.71206114
147Anophthalmia (HP:0000528)1.70928971
148Abnormal biliary tract morphology (HP:0012440)1.70675844
149Cardiomegaly (HP:0001640)1.69554398
150Intention tremor (HP:0002080)1.69426168
151Methylmalonic aciduria (HP:0012120)1.66850364
152Glomerulosclerosis (HP:0000096)1.65592461
153Growth hormone excess (HP:0000845)1.65305153
154Thin bony cortex (HP:0002753)1.64476161
155Buphthalmos (HP:0000557)1.64364205
156Widely patent fontanelles and sutures (HP:0004492)1.62562592
157Abnormality of the ischium (HP:0003174)1.62419471
158Broad metatarsal (HP:0001783)1.62329897
159Attenuation of retinal blood vessels (HP:0007843)1.62248032
160Missing ribs (HP:0000921)1.59540033
161Skin nodule (HP:0200036)1.59009495
162Progressive macrocephaly (HP:0004481)1.58547452
163Decreased lacrimation (HP:0000633)1.58469884
164Mildly elevated creatine phosphokinase (HP:0008180)1.56265317
165Syncope (HP:0001279)1.55032854
166Furrowed tongue (HP:0000221)1.54745484
167Short metatarsal (HP:0010743)1.54663787
168Ketosis (HP:0001946)1.54281754
169Neuroendocrine neoplasm (HP:0100634)1.54120077
170Labial hypoplasia (HP:0000066)1.53930868
171Protuberant abdomen (HP:0001538)1.52525615
172Hypoplastic ischia (HP:0003175)1.52072151
173Increased CSF protein (HP:0002922)1.51088621
174Patchy hypopigmentation of hair (HP:0011365)1.50747399
175Cerebral aneurysm (HP:0004944)1.44341859
176Broad thumb (HP:0011304)1.43876048
177Aneurysm (HP:0002617)1.40969532
178Hypothermia (HP:0002045)1.40782487
179Tetany (HP:0001281)1.38066391
180Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.36035352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.03613171
2INSRR5.43764261
3WNK35.25113702
4MAPK154.88112462
5DAPK24.32182212
6TAOK34.21328910
7MST43.72532264
8FRK3.46912105
9PASK3.31214916
10PRKD33.02979758
11PIK3CG2.75075336
12UHMK12.58941901
13HIPK22.52389698
14MAP3K22.49226079
15WNK42.47619884
16GRK12.34560926
17PDGFRA2.14690211
18LATS12.03305697
19MAP3K11.95348975
20MAP4K21.69394630
21ERN11.60094081
22EPHA31.59925665
23ACVR1B1.55887545
24SIK11.55480997
25CAMKK21.51519767
26STK241.49745953
27PRKCH1.45714360
28PHKG21.44928172
29PHKG11.44928172
30WNK11.44660251
31SCYL21.44188345
32PTK61.42839075
33STK381.39395740
34ADRBK21.36569896
35MAP2K61.36357382
36FGFR21.36308876
37TRIB31.33495759
38TIE11.30665396
39CDC42BPA1.28337673
40CASK1.26727838
41MAP3K121.26362118
42PAK31.26179077
43BRSK21.25529848
44PINK11.25495843
45PTK21.20877930
46TRPM71.20789559
47IRAK31.18582333
48STK31.13858593
49DAPK11.12244402
50PRKD21.10920440
51FER1.10299484
52BLK1.10131641
53MAP3K91.08675600
54MAP3K41.08119398
55PIK3CA1.07771586
56FLT31.06901050
57NTRK31.04084732
58MAPK131.02809599
59YES10.99983049
60NTRK10.98585567
61AKT30.90575339
62RET0.89757849
63ERBB30.87012940
64OXSR10.86568564
65IRAK10.85902937
66BMPR1B0.85623329
67STK38L0.85456215
68PTK2B0.84572506
69JAK10.83313691
70DDR20.79430918
71MET0.78606849
72PDGFRB0.77098673
73MYLK0.74473595
74CSNK1G10.73602996
75RIPK10.73333723
76DYRK1B0.71294834
77PRKCG0.70220887
78DAPK30.67511213
79PKN10.67250344
80NUAK10.66631038
81PRKCE0.66376283
82PRKCZ0.65396762
83AKT20.64904484
84SRC0.64822011
85PRKD10.64181451
86MARK20.64082209
87MTOR0.63204479
88PRKAA10.62357199
89JAK20.61330643
90PLK20.60646563
91FGFR10.59335896
92MKNK20.57863813
93KSR20.57788854
94EIF2AK30.57011368
95EGFR0.55687267
96BRD40.54761379
97NLK0.53396381
98TRIM280.52182445
99STK110.51319827
100GSK3A0.51158078
101CAMK1G0.50568725
102STK390.48918330
103CAMK2D0.48403035
104ERBB40.46219679
105SGK30.45603725
106CSNK1G30.44993545
107ICK0.44394171
108CSNK1G20.44028563
109PRKCI0.41407513
110FGFR30.41244019
111CAMKK10.41201800
112ALK0.38273108
113IGF1R0.37768886
114SGK2230.37514699
115SGK4940.37514699
116PRKCA0.37412124
117ADRBK10.36690963
118SGK10.36486938
119ZAP700.36254240
120EPHB10.36057798
121PRKCQ0.35615888
122ROCK10.35513949
123ITK0.35378609
124IRAK20.35200564
125MAP2K10.34473894
126BMPR20.34262407
127PRKAA20.33552608
128ROCK20.32257247
129MAP3K70.31530396
130SGK20.31236180
131CAMK1D0.30987509
132MAP2K20.30521164
133MAPK110.30222431
134TYK20.29705631
135MARK30.27819753
136TNIK0.27804738
137PDK10.27458670
138TAOK10.27316505
139NEK90.27213039
140CAMK2G0.26685418
141CSNK1A1L0.26323431
142PNCK0.26318001
143FGFR40.25350245
144MAPK140.25220474
145CHUK0.25070146
146CSNK1A10.24454143
147PRKCB0.23330856
148PRKDC0.22696131
149CAMK2B0.21621394
150NEK60.21440495
151RPS6KA30.21220574
152PRKACG0.20857566
153CSK0.20737187
154AKT10.19856355
155CDK50.18844593
156MAPK100.18654866
157PRKACA0.18619884
158RPS6KB10.17716050
159MAPK90.16791012
160PDPK10.16408179
161PRKG20.16232017
162MAPK10.16211493
163INSR0.16188103
164PRKG10.15733127

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.81824647
2Steroid hormone biosynthesis_Homo sapiens_hsa001405.65254490
3Protein export_Homo sapiens_hsa030603.78089777
4Folate biosynthesis_Homo sapiens_hsa007903.48411131
5Insulin secretion_Homo sapiens_hsa049113.47855421
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.12626605
7Type II diabetes mellitus_Homo sapiens_hsa049302.78237321
8Type I diabetes mellitus_Homo sapiens_hsa049402.74927727
9Jak-STAT signaling pathway_Homo sapiens_hsa046302.25757893
10Vitamin B6 metabolism_Homo sapiens_hsa007502.16869531
11Sulfur metabolism_Homo sapiens_hsa009201.93876262
12Mineral absorption_Homo sapiens_hsa049781.79932546
13N-Glycan biosynthesis_Homo sapiens_hsa005101.76550049
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75975994
15Cocaine addiction_Homo sapiens_hsa050301.67791834
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.65955166
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61160016
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60109300
19Tryptophan metabolism_Homo sapiens_hsa003801.53383855
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.45111498
21Vibrio cholerae infection_Homo sapiens_hsa051101.40675201
22Collecting duct acid secretion_Homo sapiens_hsa049661.37642037
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35914131
24Pancreatic secretion_Homo sapiens_hsa049721.35267519
25Lysosome_Homo sapiens_hsa041421.29305139
26Amphetamine addiction_Homo sapiens_hsa050311.24293032
27Protein digestion and absorption_Homo sapiens_hsa049741.23360454
28Glucagon signaling pathway_Homo sapiens_hsa049221.20620128
29Thyroid hormone synthesis_Homo sapiens_hsa049181.18320137
30Histidine metabolism_Homo sapiens_hsa003401.17273429
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15340421
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15333755
33Salivary secretion_Homo sapiens_hsa049701.13888951
34Insulin resistance_Homo sapiens_hsa049311.04944416
35Butanoate metabolism_Homo sapiens_hsa006501.02904367
36Estrogen signaling pathway_Homo sapiens_hsa049151.01532399
37Prion diseases_Homo sapiens_hsa050201.00643374
38Dorso-ventral axis formation_Homo sapiens_hsa043200.99854720
39Vascular smooth muscle contraction_Homo sapiens_hsa042700.96198055
40Cholinergic synapse_Homo sapiens_hsa047250.96029480
41Renin secretion_Homo sapiens_hsa049240.95033258
42Circadian rhythm_Homo sapiens_hsa047100.93915260
43Taste transduction_Homo sapiens_hsa047420.92809232
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92404337
45Hedgehog signaling pathway_Homo sapiens_hsa043400.91709897
46Ether lipid metabolism_Homo sapiens_hsa005650.90692471
47Phototransduction_Homo sapiens_hsa047440.89644612
48Arginine biosynthesis_Homo sapiens_hsa002200.88407050
49Dopaminergic synapse_Homo sapiens_hsa047280.88320638
50ABC transporters_Homo sapiens_hsa020100.86752801
51Circadian entrainment_Homo sapiens_hsa047130.83049851
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80922140
53Tight junction_Homo sapiens_hsa045300.80844229
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80827202
55Vitamin digestion and absorption_Homo sapiens_hsa049770.80023352
56Oxidative phosphorylation_Homo sapiens_hsa001900.79534337
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79203694
58Prolactin signaling pathway_Homo sapiens_hsa049170.79064023
59mTOR signaling pathway_Homo sapiens_hsa041500.78242982
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78143710
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78055764
62Propanoate metabolism_Homo sapiens_hsa006400.77909543
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77815390
64GABAergic synapse_Homo sapiens_hsa047270.76987381
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76511073
66Ovarian steroidogenesis_Homo sapiens_hsa049130.76454171
67cAMP signaling pathway_Homo sapiens_hsa040240.76220285
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75577406
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73797260
70Serotonergic synapse_Homo sapiens_hsa047260.73437616
71Melanogenesis_Homo sapiens_hsa049160.72793428
72Prostate cancer_Homo sapiens_hsa052150.72712805
73Long-term potentiation_Homo sapiens_hsa047200.70006366
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68917136
75Other glycan degradation_Homo sapiens_hsa005110.68134802
76Metabolic pathways_Homo sapiens_hsa011000.67409337
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65376104
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65017946
79Renal cell carcinoma_Homo sapiens_hsa052110.64395677
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64113211
81Linoleic acid metabolism_Homo sapiens_hsa005910.63433787
82Wnt signaling pathway_Homo sapiens_hsa043100.62287154
83Peroxisome_Homo sapiens_hsa041460.61841556
84Inositol phosphate metabolism_Homo sapiens_hsa005620.61532588
85Gap junction_Homo sapiens_hsa045400.61371316
86Insulin signaling pathway_Homo sapiens_hsa049100.60205536
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60135807
88Thyroid cancer_Homo sapiens_hsa052160.59488910
89Dilated cardiomyopathy_Homo sapiens_hsa054140.58837430
90Fatty acid elongation_Homo sapiens_hsa000620.58299374
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58193451
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58181146
93Regulation of autophagy_Homo sapiens_hsa041400.56397873
94Morphine addiction_Homo sapiens_hsa050320.55997574
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.54953470
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54800270
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54298818
98Selenocompound metabolism_Homo sapiens_hsa004500.54136092
99Complement and coagulation cascades_Homo sapiens_hsa046100.53972108
100Basal cell carcinoma_Homo sapiens_hsa052170.53890686
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.52654118
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51581078
103Focal adhesion_Homo sapiens_hsa045100.50908845
104GnRH signaling pathway_Homo sapiens_hsa049120.50749321
105Bladder cancer_Homo sapiens_hsa052190.49922445
106Adherens junction_Homo sapiens_hsa045200.49797846
107Retinol metabolism_Homo sapiens_hsa008300.49534051
108Long-term depression_Homo sapiens_hsa047300.48473730
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48365900
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48167315
111Lysine degradation_Homo sapiens_hsa003100.47357458
112Nicotine addiction_Homo sapiens_hsa050330.47269116
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47235547
114Ras signaling pathway_Homo sapiens_hsa040140.46931831
115Glutamatergic synapse_Homo sapiens_hsa047240.46795139
116Sphingolipid metabolism_Homo sapiens_hsa006000.45896052
117Gastric acid secretion_Homo sapiens_hsa049710.45503105
118Renin-angiotensin system_Homo sapiens_hsa046140.45471930
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45304643
120Amoebiasis_Homo sapiens_hsa051460.45284989
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44905622
122AMPK signaling pathway_Homo sapiens_hsa041520.44795215
123Endometrial cancer_Homo sapiens_hsa052130.44545255
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44239531
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.42345603
126Fat digestion and absorption_Homo sapiens_hsa049750.40895648
127Chronic myeloid leukemia_Homo sapiens_hsa052200.40622378
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40620790
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40618353
130Axon guidance_Homo sapiens_hsa043600.40094408
131Alcoholism_Homo sapiens_hsa050340.38779621
132Arginine and proline metabolism_Homo sapiens_hsa003300.38763700
133Synaptic vesicle cycle_Homo sapiens_hsa047210.38457161
134Melanoma_Homo sapiens_hsa052180.37594538
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37310575
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37110547
137Proteoglycans in cancer_Homo sapiens_hsa052050.36422968
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36275839
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34915972
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34906294
141Calcium signaling pathway_Homo sapiens_hsa040200.33008601
142ECM-receptor interaction_Homo sapiens_hsa045120.32316427
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28493479
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28112955
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27877960
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27051677
147Glutathione metabolism_Homo sapiens_hsa004800.26968095
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26839167

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