PAPSS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)8.00654563
2central nervous system myelination (GO:0022010)7.44480548
3axon ensheathment in central nervous system (GO:0032291)7.44480548
4presynaptic membrane assembly (GO:0097105)6.42638136
5ensheathment of neurons (GO:0007272)4.82189987
6axon ensheathment (GO:0008366)4.82189987
7myelination (GO:0042552)4.77499913
8fatty acid elongation (GO:0030497)4.62733440
9pyrimidine nucleobase catabolic process (GO:0006208)4.62565442
10cullin deneddylation (GO:0010388)4.48746712
11myelin maintenance (GO:0043217)4.34706229
12protein deneddylation (GO:0000338)4.12107987
13oligodendrocyte differentiation (GO:0048709)3.92369527
14histone H2A acetylation (GO:0043968)3.86514823
15protein localization to cilium (GO:0061512)3.73284558
16photoreceptor cell differentiation (GO:0046530)3.71725396
17eye photoreceptor cell differentiation (GO:0001754)3.71725396
18apical protein localization (GO:0045176)3.67788332
19somite development (GO:0061053)3.66881023
20intraciliary transport (GO:0042073)3.66074821
21long-chain fatty acid biosynthetic process (GO:0042759)3.64598414
22DNA double-strand break processing (GO:0000729)3.57096439
23membrane assembly (GO:0071709)3.55561953
24asymmetric protein localization (GO:0008105)3.51376295
25nucleobase catabolic process (GO:0046113)3.51058031
26peripheral nervous system axon ensheathment (GO:0032292)3.45009463
27myelination in peripheral nervous system (GO:0022011)3.45009463
28negative regulation of neurotransmitter secretion (GO:0046929)3.43157813
29positive regulation of oligodendrocyte differentiation (GO:0048714)3.38208326
30peptidyl-tyrosine autophosphorylation (GO:0038083)3.34170265
31positive regulation of pseudopodium assembly (GO:0031274)3.32116819
32negative regulation of neurotransmitter transport (GO:0051589)3.31897144
33L-amino acid import (GO:0043092)3.27161399
34mannosylation (GO:0097502)3.20390848
35sequestering of actin monomers (GO:0042989)3.16664223
36negative regulation of protein localization to cell surface (GO:2000009)3.15517013
37neural tube formation (GO:0001841)3.12416597
38glial cell proliferation (GO:0014009)3.10354423
39peptidyl-cysteine modification (GO:0018198)3.09861006
40cholesterol biosynthetic process (GO:0006695)3.08784271
41histone H3-K36 demethylation (GO:0070544)3.08336292
42regulation of collateral sprouting (GO:0048670)3.03121719
43positive regulation of synapse assembly (GO:0051965)3.02295976
44amino acid import (GO:0043090)2.99942326
45neuron projection extension involved in neuron projection guidance (GO:1902284)2.96745353
46axon extension involved in axon guidance (GO:0048846)2.96745353
47astrocyte development (GO:0014002)2.94771260
48nerve growth factor signaling pathway (GO:0038180)2.92682048
49establishment of mitochondrion localization (GO:0051654)2.88289205
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87904454
51neuron cell-cell adhesion (GO:0007158)2.87305893
52ganglion development (GO:0061548)2.85144823
53calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.85010830
54generation of neurons (GO:0048699)2.84576942
55DNA damage response, detection of DNA damage (GO:0042769)2.84188853
56limb bud formation (GO:0060174)2.82979342
57regulation of short-term neuronal synaptic plasticity (GO:0048172)2.81520848
58cilium morphogenesis (GO:0060271)2.81084920
59long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.80710307
60isoprenoid biosynthetic process (GO:0008299)2.79689237
61vocalization behavior (GO:0071625)2.79397126
62platelet dense granule organization (GO:0060155)2.78498552
63response to lipoprotein particle (GO:0055094)2.77142626
64neuron recognition (GO:0008038)2.76680441
65protein localization to synapse (GO:0035418)2.74329880
66regulation of pseudopodium assembly (GO:0031272)2.73589488
67protein palmitoylation (GO:0018345)2.72545093
68negative regulation of axonogenesis (GO:0050771)2.70690613
69response to methylmercury (GO:0051597)2.69841155
70retinal ganglion cell axon guidance (GO:0031290)2.69762076
71sterol biosynthetic process (GO:0016126)2.68148845
72cerebral cortex radially oriented cell migration (GO:0021799)2.66675957
73negative chemotaxis (GO:0050919)2.66296523
74postsynaptic membrane organization (GO:0001941)2.64225006
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62946395
76virion attachment to host cell (GO:0019062)2.62627915
77adhesion of symbiont to host cell (GO:0044650)2.62627915
78neuronal ion channel clustering (GO:0045161)2.60064211
79positive regulation of dendrite morphogenesis (GO:0050775)2.58750158
80magnesium ion transport (GO:0015693)2.57938099
81establishment of melanosome localization (GO:0032401)2.57426451
82creatine metabolic process (GO:0006600)2.56529306
83melanosome transport (GO:0032402)2.56496585
84negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.56121940
85response to redox state (GO:0051775)2.53691039
86dendrite morphogenesis (GO:0048813)2.52575527
87negative regulation of DNA recombination (GO:0045910)2.51928459
88layer formation in cerebral cortex (GO:0021819)2.51698395
89long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.51542349
90female gonad development (GO:0008585)2.50737016
91negative regulation of axon extension (GO:0030517)2.50420957
92transmission of nerve impulse (GO:0019226)2.47135370
93epithelial cilium movement (GO:0003351)2.47053683
94axonal fasciculation (GO:0007413)2.46317728
95ER overload response (GO:0006983)2.46134424
96substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.46009714
97substrate-independent telencephalic tangential migration (GO:0021826)2.46009714
98substantia nigra development (GO:0021762)2.45918158
99otic vesicle formation (GO:0030916)2.45423362
100synapse assembly (GO:0007416)2.45172974
101regulation of chemokine-mediated signaling pathway (GO:0070099)2.44753873
102regulation of mitotic spindle checkpoint (GO:1903504)2.44323142
103regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.44323142
104positive regulation of mitochondrial fission (GO:0090141)2.43615641
105establishment of pigment granule localization (GO:0051905)2.43070661
106axon extension (GO:0048675)2.42639217
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42381779
108pigment granule transport (GO:0051904)2.41530526
109negative regulation of exocytosis (GO:0045920)2.41179722
110regulation of autophagic vacuole assembly (GO:2000785)2.40601424
111positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.40232930
112glial cell differentiation (GO:0010001)2.38770551
113astrocyte differentiation (GO:0048708)2.38615196
114ionotropic glutamate receptor signaling pathway (GO:0035235)2.37915374
115positive regulation of dendritic spine morphogenesis (GO:0061003)2.37905763
116protein localization to endosome (GO:0036010)2.37899066
117dendritic spine morphogenesis (GO:0060997)2.37463880
118regulation of cilium movement (GO:0003352)2.37152951
119amyloid precursor protein metabolic process (GO:0042982)2.36027928
120DNA integration (GO:0015074)2.35545195
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.35504627
122membrane tubulation (GO:0097320)2.35087211
123neuron remodeling (GO:0016322)2.34693517
124sympathetic nervous system development (GO:0048485)2.34029722
125protein-cofactor linkage (GO:0018065)2.33503571
126negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33411241
127melanosome localization (GO:0032400)2.33288094
128cell wall macromolecule catabolic process (GO:0016998)2.32983081
129retinal rod cell development (GO:0046548)2.32675788
130positive regulation of actin filament depolymerization (GO:0030836)2.32203593
131neuroblast proliferation (GO:0007405)2.32155071
132negative regulation of axon guidance (GO:1902668)2.31143269
133glycerophospholipid catabolic process (GO:0046475)2.30174655
134fatty-acyl-CoA biosynthetic process (GO:0046949)2.29681025
135regulation of somitogenesis (GO:0014807)2.29467383
136de novo posttranslational protein folding (GO:0051084)2.29413998
137short-term memory (GO:0007614)2.29140606
138CENP-A containing nucleosome assembly (GO:0034080)2.28794375
139chromatin remodeling at centromere (GO:0031055)2.28793261
140peripheral nervous system development (GO:0007422)2.28763247
141regulation of synapse assembly (GO:0051963)2.28484182
142positive regulation of glial cell differentiation (GO:0045687)2.28171559
143cilium assembly (GO:0042384)2.27936201
144cilium organization (GO:0044782)2.27454612
145base-excision repair, AP site formation (GO:0006285)2.27283167
146regulation of telomere maintenance (GO:0032204)2.25821846
147prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.25377841
148regulation of development, heterochronic (GO:0040034)2.24943727
149neuron projection extension (GO:1990138)2.24508711
150de novo protein folding (GO:0006458)2.24346879
151cerebral cortex cell migration (GO:0021795)2.24223288
152acrosome assembly (GO:0001675)2.23567467
153import into cell (GO:0098657)2.23269721
154organelle disassembly (GO:1903008)2.23007255
155L-serine metabolic process (GO:0006563)2.22395829
156cytoskeleton-dependent intracellular transport (GO:0030705)2.21189973
157positive regulation of dendrite development (GO:1900006)2.21060256
158pigment granule localization (GO:0051875)2.21046301
159resolution of meiotic recombination intermediates (GO:0000712)2.20965571
160peptidyl-arginine methylation (GO:0018216)2.19405848
161peptidyl-arginine N-methylation (GO:0035246)2.19405848
162ATP hydrolysis coupled proton transport (GO:0015991)2.18856619
163energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.18856619
164positive regulation of gliogenesis (GO:0014015)2.17865586
165synaptic transmission, glutamatergic (GO:0035249)2.17596847
166semaphorin-plexin signaling pathway (GO:0071526)2.17224052
167protein neddylation (GO:0045116)2.16761985
168microtubule-based transport (GO:0010970)2.16185947
169regulation of oligodendrocyte differentiation (GO:0048713)2.15154298
170adult walking behavior (GO:0007628)2.14630935
171membrane hyperpolarization (GO:0060081)2.14591920
172limb development (GO:0060173)2.14545141
173appendage development (GO:0048736)2.14545141
174regulation of axon extension involved in axon guidance (GO:0048841)2.14474721
175ribonucleoprotein complex disassembly (GO:0032988)2.14181650
176regulation of dendrite morphogenesis (GO:0048814)2.13824979
177negative regulation of JUN kinase activity (GO:0043508)2.12482734
178regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.12334522
179myelin assembly (GO:0032288)2.11922763
180hippocampus development (GO:0021766)2.11554695
181anterograde synaptic vesicle transport (GO:0048490)2.11385005
182cornea development in camera-type eye (GO:0061303)2.11222760
183negative regulation of axon extension involved in axon guidance (GO:0048843)2.11060368
184enteric nervous system development (GO:0048484)2.10104503
185camera-type eye morphogenesis (GO:0048593)2.09901101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.27822565
2GBX2_23144817_ChIP-Seq_PC3_Human3.26486050
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.08061036
4EZH2_22144423_ChIP-Seq_EOC_Human2.94041517
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70407055
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58100319
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51069992
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47947760
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47253577
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41806048
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40288855
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40288855
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36220593
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.35967776
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27839078
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27359184
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.25394676
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24077363
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21260225
20AR_21572438_ChIP-Seq_LNCaP_Human2.15451094
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14983222
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11691404
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07723445
24* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.06568960
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.04508375
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.01247407
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.00093484
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99736088
29EWS_26573619_Chip-Seq_HEK293_Human1.98751766
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92112549
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89339331
32ELK1_19687146_ChIP-ChIP_HELA_Human1.88863546
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.88482774
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79624483
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78025831
36VDR_22108803_ChIP-Seq_LS180_Human1.76757486
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.71704980
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70859080
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70269035
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69471322
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68919607
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65704560
43DROSHA_22980978_ChIP-Seq_HELA_Human1.64946495
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.62108039
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.61077449
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54883409
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53458494
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52462565
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52113728
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51899881
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.48234833
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48038709
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47388403
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45536856
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.44693942
56TAF15_26573619_Chip-Seq_HEK293_Human1.44134734
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43521455
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.41349777
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.40701130
60* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39864165
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.38546132
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.37810179
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.37190133
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35484006
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35343364
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34698490
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33954176
68AHR_22903824_ChIP-Seq_MCF-7_Human1.31937078
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31663228
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29977191
71* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29552656
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29348954
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27209349
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.26622223
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26345829
76IGF1R_20145208_ChIP-Seq_DFB_Human1.26297743
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26155764
78* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25915071
79* CBP_20019798_ChIP-Seq_JUKART_Human1.25915071
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24356310
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.23746240
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23354600
83* SMAD4_21799915_ChIP-Seq_A2780_Human1.23344765
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22986023
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22986023
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22632881
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22032592
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20874066
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.19473478
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18237897
91BCAT_22108803_ChIP-Seq_LS180_Human1.18216518
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.18133364
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.16087747
94P300_19829295_ChIP-Seq_ESCs_Human1.15885537
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15764599
96POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15671435
97ER_23166858_ChIP-Seq_MCF-7_Human1.14320162
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13005685
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12953998
100* NANOG_18555785_Chip-Seq_ESCs_Mouse1.12858211
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12717651
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12639698
103* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12495876
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11934235
105REST_21632747_ChIP-Seq_MESCs_Mouse1.11689396
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11467155
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10833272
108* RUNX2_22187159_ChIP-Seq_PCA_Human1.10588381
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10317794
110STAT3_23295773_ChIP-Seq_U87_Human1.09752130
111TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08291952
112TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08209570
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07648225
114FUS_26573619_Chip-Seq_HEK293_Human1.07380402
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06720772
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06309122
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05094239
118E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04893451
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04214147
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03960760
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02848791
122RNF2_27304074_Chip-Seq_NSC_Mouse1.00969390
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00900954
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00753037
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00568797
126MYC_18940864_ChIP-ChIP_HL60_Human1.00553802
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.00546550
128ISL1_27105846_Chip-Seq_CPCs_Mouse1.00292749
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00049508
130* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99263062
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98755465
132* TCF4_22108803_ChIP-Seq_LS180_Human0.98111849
133* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97590528
134SOX9_26525672_Chip-Seq_HEART_Mouse0.97200367
135SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97146280
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.96308417
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95827521
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95757046
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95587942
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.94998599
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.94841841
142TCF4_23295773_ChIP-Seq_U87_Human0.94818091
143TP53_18474530_ChIP-ChIP_U2OS_Human0.94781644
144LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93345857
145POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93220578
146JUN_21703547_ChIP-Seq_K562_Human0.93120152
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93074241
148PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92634104
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.91864002
150* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91167259
151ESR1_21235772_ChIP-Seq_MCF-7_Human0.90786236
152TP53_16413492_ChIP-PET_HCT116_Human0.90649329
153CJUN_26792858_Chip-Seq_BT549_Human0.90312849
154* SOX2_20726797_ChIP-Seq_SW620_Human0.89956045
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88980453
156AR_25329375_ChIP-Seq_VCAP_Human0.88969063
157* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88194007
158SMAD3_21741376_ChIP-Seq_ESCs_Human0.87673290
159REST_18959480_ChIP-ChIP_MESCs_Mouse0.87264640
160AR_19668381_ChIP-Seq_PC3_Human0.86760083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation3.82423880
2MP0000920_abnormal_myelination3.55852067
3MP0010030_abnormal_orbit_morphology3.14564086
4MP0000462_abnormal_digestive_system2.80105036
5MP0002102_abnormal_ear_morphology2.67272636
6MP0004270_analgesia2.63149734
7MP0004885_abnormal_endolymph2.61624949
8MP0004859_abnormal_synaptic_plasticity2.60993155
9MP0003121_genomic_imprinting2.36712811
10MP0008789_abnormal_olfactory_epithelium2.32188476
11MP0000778_abnormal_nervous_system2.25568911
12MP0000516_abnormal_urinary_system2.25035385
13MP0005367_renal/urinary_system_phenotyp2.25035385
14MP0001984_abnormal_olfaction2.11042017
15MP0003880_abnormal_central_pattern2.07050743
16MP0004134_abnormal_chest_morphology2.06532750
17MP0004133_heterotaxia2.05737577
18MP0010678_abnormal_skin_adnexa2.05454875
19MP0003634_abnormal_glial_cell2.01352875
20MP0004272_abnormal_basement_membrane1.94497804
21MP0003329_amyloid_beta_deposits1.91394210
22MP0002736_abnormal_nociception_after1.90602123
23MP0004043_abnormal_pH_regulation1.87918206
24MP0002751_abnormal_autonomic_nervous1.87342479
25MP0008877_abnormal_DNA_methylation1.86672880
26MP0005394_taste/olfaction_phenotype1.86128523
27MP0005499_abnormal_olfactory_system1.86128523
28MP0009780_abnormal_chondrocyte_physiolo1.85992554
29MP0002272_abnormal_nervous_system1.84218528
30MP0003890_abnormal_embryonic-extraembry1.82136618
31MP0003635_abnormal_synaptic_transmissio1.81625701
32MP0003690_abnormal_glial_cell1.81176925
33MP0004742_abnormal_vestibular_system1.76899580
34MP0000383_abnormal_hair_follicle1.73229849
35MP0001188_hyperpigmentation1.72749426
36MP0003567_abnormal_fetal_cardiomyocyte1.71953379
37MP0002064_seizures1.71340946
38MP0001486_abnormal_startle_reflex1.69012410
39MP0006054_spinal_hemorrhage1.64301088
40MP0008438_abnormal_cutaneous_collagen1.63336832
41MP0005248_abnormal_Harderian_gland1.62520315
42MP0006292_abnormal_olfactory_placode1.58316144
43MP0001299_abnormal_eye_distance/1.57197710
44MP0003119_abnormal_digestive_system1.56693145
45MP0001485_abnormal_pinna_reflex1.55939467
46MP0005623_abnormal_meninges_morphology1.54845733
47MP0001529_abnormal_vocalization1.54150612
48MP0009745_abnormal_behavioral_response1.53065034
49MP0001346_abnormal_lacrimal_gland1.49514576
50MP0001293_anophthalmia1.46436673
51MP0000955_abnormal_spinal_cord1.44283646
52MP0003632_abnormal_nervous_system1.41492771
53MP0000762_abnormal_tongue_morphology1.40008560
54MP0002063_abnormal_learning/memory/cond1.39988739
55MP0008058_abnormal_DNA_repair1.38961249
56MP0002938_white_spotting1.38158494
57MP0003938_abnormal_ear_development1.38039261
58MP0003718_maternal_effect1.37579038
59MP0000049_abnormal_middle_ear1.36114028
60MP0002734_abnormal_mechanical_nocicepti1.35322836
61MP0009250_abnormal_appendicular_skeleto1.34773204
62MP0005253_abnormal_eye_physiology1.34371609
63MP0000647_abnormal_sebaceous_gland1.34318692
64MP0000467_abnormal_esophagus_morphology1.33993009
65MP0003937_abnormal_limbs/digits/tail_de1.32969835
66MP0006276_abnormal_autonomic_nervous1.32475543
67MP0003941_abnormal_skin_development1.32021999
68MP0003385_abnormal_body_wall1.30176966
69MP0003950_abnormal_plasma_membrane1.28432230
70MP0002282_abnormal_trachea_morphology1.27589126
71MP0009384_cardiac_valve_regurgitation1.25799880
72MP0001968_abnormal_touch/_nociception1.24142637
73MP0009046_muscle_twitch1.23267054
74MP0002572_abnormal_emotion/affect_behav1.23134553
75MP0000537_abnormal_urethra_morphology1.22691511
76MP0002882_abnormal_neuron_morphology1.21873949
77MP0008569_lethality_at_weaning1.21856811
78MP0004147_increased_porphyrin_level1.21240557
79MP0003136_yellow_coat_color1.20282668
80MP0002896_abnormal_bone_mineralization1.19101362
81MP0003787_abnormal_imprinting1.17722274
82MP0003183_abnormal_peptide_metabolism1.13763832
83MP0002229_neurodegeneration1.13001897
84MP0005551_abnormal_eye_electrophysiolog1.12669537
85MP0004858_abnormal_nervous_system1.12303790
86MP0001286_abnormal_eye_development1.09848176
87MP0001905_abnormal_dopamine_level1.08697318
88MP0005408_hypopigmentation1.07834382
89MP0003861_abnormal_nervous_system1.07730326
90MP0003631_nervous_system_phenotype1.06988249
91MP0002733_abnormal_thermal_nociception1.06383466
92MP0003935_abnormal_craniofacial_develop1.06266932
93MP0009379_abnormal_foot_pigmentation1.04572695
94MP0002090_abnormal_vision1.04453863
95MP0001970_abnormal_pain_threshold1.03650432
96MP0005409_darkened_coat_color1.01921661
97MP0003633_abnormal_nervous_system1.01806457
98MP0005423_abnormal_somatic_nervous1.01377222
99MP0003115_abnormal_respiratory_system1.01262715
100MP0001177_atelectasis1.00146299
101MP0002697_abnormal_eye_size0.99656282
102MP0002234_abnormal_pharynx_morphology0.99122431
103MP0002557_abnormal_social/conspecific_i0.99113958
104MP0002067_abnormal_sensory_capabilities0.98870985
105MP0001963_abnormal_hearing_physiology0.97143562
106MP0005084_abnormal_gallbladder_morpholo0.97056306
107MP0001440_abnormal_grooming_behavior0.97034306
108MP0000566_synostosis0.96878331
109MP0002098_abnormal_vibrissa_morphology0.95354098
110MP0005187_abnormal_penis_morphology0.94657489
111MP0002184_abnormal_innervation0.94618292
112MP0008932_abnormal_embryonic_tissue0.94218291
113MP0006072_abnormal_retinal_apoptosis0.94153025
114MP0002066_abnormal_motor_capabilities/c0.94077943
115MP0000003_abnormal_adipose_tissue0.94066911
116MP0001340_abnormal_eyelid_morphology0.93819764
117MP0003122_maternal_imprinting0.93534843
118MP0009703_decreased_birth_body0.93177683
119MP0001324_abnormal_eye_pigmentation0.92541584
120MP0001664_abnormal_digestion0.92460098
121MP0000631_abnormal_neuroendocrine_gland0.92287062
122MP0002177_abnormal_outer_ear0.91199143
123MP0008995_early_reproductive_senescence0.90487768
124MP0001958_emphysema0.90447403
125MP0002735_abnormal_chemical_nociception0.90182982
126MP0000579_abnormal_nail_morphology0.89906110
127MP0000678_abnormal_parathyroid_gland0.89898130
128MP0002152_abnormal_brain_morphology0.89253890
129MP0004142_abnormal_muscle_tone0.88919716
130MP0000613_abnormal_salivary_gland0.88357369
131MP0000013_abnormal_adipose_tissue0.88272636
132MP0000534_abnormal_ureter_morphology0.87988538
133MP0002653_abnormal_ependyma_morphology0.87626393
134MP0002638_abnormal_pupillary_reflex0.86572550
135MP0010386_abnormal_urinary_bladder0.86034409
136MP0002084_abnormal_developmental_patter0.85812263
137MP0001849_ear_inflammation0.85717959
138MP0000747_muscle_weakness0.85442350
139MP0002752_abnormal_somatic_nervous0.85410323
140MP0002277_abnormal_respiratory_mucosa0.85035009
141MP0005391_vision/eye_phenotype0.83185180
142MP0009672_abnormal_birth_weight0.82522259
143MP0002111_abnormal_tail_morphology0.81631693
144MP0004811_abnormal_neuron_physiology0.81499230
145MP0000026_abnormal_inner_ear0.80952199
146MP0003283_abnormal_digestive_organ0.80581507
147MP0005645_abnormal_hypothalamus_physiol0.80325453
148MP0002069_abnormal_eating/drinking_beha0.79037911
149MP0002233_abnormal_nose_morphology0.77082391
150MP0000372_irregular_coat_pigmentation0.77043226
151MP0001986_abnormal_taste_sensitivity0.76537192
152MP0002932_abnormal_joint_morphology0.75672028
153MP0003942_abnormal_urinary_system0.75650089
154MP0003755_abnormal_palate_morphology0.74245873
155MP0005195_abnormal_posterior_eye0.72492519

Predicted human phenotypes

RankGene SetZ-score
1Buphthalmos (HP:0000557)4.87081345
2Cerebellar dysplasia (HP:0007033)4.74790537
3Abnormality of the labia minora (HP:0012880)4.56176921
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.40491349
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.40491349
6Type II lissencephaly (HP:0007260)4.37345401
7Neurofibrillary tangles (HP:0002185)4.24785074
8Retinal dysplasia (HP:0007973)4.17841859
9Anterior segment dysgenesis (HP:0007700)3.96707527
10Ankle clonus (HP:0011448)3.75130869
11Termporal pattern (HP:0011008)3.35082951
12Insidious onset (HP:0003587)3.35082951
13Abnormality of the corticospinal tract (HP:0002492)3.30653717
14Cortical dysplasia (HP:0002539)3.27471598
15Spinal rigidity (HP:0003306)3.25564172
16Retinal atrophy (HP:0001105)3.24938588
17Cerebral inclusion bodies (HP:0100314)3.23984511
18Congenital glaucoma (HP:0001087)3.23468185
19Stomach cancer (HP:0012126)3.20573490
20Bifid tongue (HP:0010297)3.00107214
21Peripheral hypomyelination (HP:0007182)2.98807074
22Scanning speech (HP:0002168)2.95539695
23Sensory axonal neuropathy (HP:0003390)2.87014528
24Onion bulb formation (HP:0003383)2.86901982
25Septo-optic dysplasia (HP:0100842)2.79342514
26Spastic gait (HP:0002064)2.79029923
27Colon cancer (HP:0003003)2.78038530
28Gait imbalance (HP:0002141)2.75095246
29Increased circulating renin level (HP:0000848)2.72605599
30Megalencephaly (HP:0001355)2.70278139
31Alacrima (HP:0000522)2.67799847
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65393440
33Vaginal atresia (HP:0000148)2.61978429
34Nephrogenic diabetes insipidus (HP:0009806)2.60799529
35Abnormal auditory evoked potentials (HP:0006958)2.59582936
36Genital tract atresia (HP:0001827)2.59033955
37Polyphagia (HP:0002591)2.57974406
38Drooling (HP:0002307)2.53107787
39Supranuclear gaze palsy (HP:0000605)2.51937318
40Congenital primary aphakia (HP:0007707)2.51931207
41Medial flaring of the eyebrow (HP:0010747)2.51453876
42Intention tremor (HP:0002080)2.48513289
43Hepatoblastoma (HP:0002884)2.46924553
44Intellectual disability, moderate (HP:0002342)2.42633159
45White forelock (HP:0002211)2.40476435
46Tubulointerstitial nephritis (HP:0001970)2.38932381
47True hermaphroditism (HP:0010459)2.38138842
48Aplasia involving bones of the upper limbs (HP:0009823)2.38125388
49Aplasia of the phalanges of the hand (HP:0009802)2.38125388
50Aplasia involving bones of the extremities (HP:0009825)2.38125388
51Hip dysplasia (HP:0001385)2.37939681
52Premature skin wrinkling (HP:0100678)2.37548498
53Segmental peripheral demyelination/remyelination (HP:0003481)2.36394469
54Hypoplasia of the iris (HP:0007676)2.35597935
55Hypomagnesemia (HP:0002917)2.35527323
56Metabolic alkalosis (HP:0200114)2.30137018
57Absent septum pellucidum (HP:0001331)2.29374301
58Hypoplasia of the brainstem (HP:0002365)2.28218472
59Aplasia/Hypoplasia of the brainstem (HP:0007362)2.28218472
60Absent speech (HP:0001344)2.27421847
61Molar tooth sign on MRI (HP:0002419)2.26409206
62Abnormality of midbrain morphology (HP:0002418)2.26409206
63Ependymoma (HP:0002888)2.25721948
64Myokymia (HP:0002411)2.25384453
65Short tibia (HP:0005736)2.24918778
66Amyotrophic lateral sclerosis (HP:0007354)2.24865603
67Intestinal atresia (HP:0011100)2.24405395
68Labial hypoplasia (HP:0000066)2.24169267
69Occipital encephalocele (HP:0002085)2.24123826
70Excessive salivation (HP:0003781)2.19434925
71Atrophy/Degeneration involving motor neurons (HP:0007373)2.18930045
72Decreased muscle mass (HP:0003199)2.18603566
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.18567398
74Pancreatic fibrosis (HP:0100732)2.17742099
75Patchy hypopigmentation of hair (HP:0011365)2.16834199
76Methylmalonic acidemia (HP:0002912)2.16632364
77Hyperglycinemia (HP:0002154)2.16233800
78Stenosis of the external auditory canal (HP:0000402)2.15299065
79Pancreatic cysts (HP:0001737)2.12823372
80Abnormal lung lobation (HP:0002101)2.12602460
81Anencephaly (HP:0002323)2.09745716
82Anteriorly placed anus (HP:0001545)2.09483655
83Nephronophthisis (HP:0000090)2.06903597
84Hypoplastic female external genitalia (HP:0012815)2.06623838
85Dandy-Walker malformation (HP:0001305)2.05940085
86Split foot (HP:0001839)2.05444563
87Lower limb muscle weakness (HP:0007340)2.05299759
88Abnormal respiratory epithelium morphology (HP:0012253)2.04857823
89Abnormal respiratory motile cilium morphology (HP:0005938)2.04857823
90Parakeratosis (HP:0001036)2.03590256
91Akinesia (HP:0002304)2.03542008
92Hypokalemic alkalosis (HP:0001949)2.03257379
93Meningocele (HP:0002435)2.02721982
94Abnormality of the anterior chamber (HP:0000593)2.01720507
95Postaxial hand polydactyly (HP:0001162)2.01601693
96Aplasia/Hypoplasia of the tibia (HP:0005772)2.00854437
97Astrocytoma (HP:0009592)2.00732211
98Abnormality of the astrocytes (HP:0100707)2.00732211
99Abnormality of the septum pellucidum (HP:0007375)1.99948028
100Failure to thrive in infancy (HP:0001531)1.99740633
101Renal hypoplasia (HP:0000089)1.98490314
102Micropenis (HP:0000054)1.96784844
103Focal motor seizures (HP:0011153)1.96466390
104Decreased lacrimation (HP:0000633)1.96109691
105Narrow forehead (HP:0000341)1.95773622
106Lissencephaly (HP:0001339)1.95435120
107Pheochromocytoma (HP:0002666)1.94853390
108Abnormality of magnesium homeostasis (HP:0004921)1.94009313
109Agnosia (HP:0010524)1.92339963
110Humeroradial synostosis (HP:0003041)1.91687627
111Synostosis involving the elbow (HP:0003938)1.91687627
112Esophageal atresia (HP:0002032)1.91195043
113Specific learning disability (HP:0001328)1.90193704
114Cerebral hypomyelination (HP:0006808)1.89681805
115Scrotal hypoplasia (HP:0000046)1.89608217
116Thickened helices (HP:0000391)1.89531319
117Coronal craniosynostosis (HP:0004440)1.89429852
118Thyroid-stimulating hormone excess (HP:0002925)1.89382179
119Broad foot (HP:0001769)1.88455278
120Morphological abnormality of the inner ear (HP:0011390)1.88419261
121Supernumerary spleens (HP:0009799)1.87109238
122Bell-shaped thorax (HP:0001591)1.86768078
123Poor suck (HP:0002033)1.86529433
124Spastic tetraparesis (HP:0001285)1.86464680
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.85959331
126Cutaneous finger syndactyly (HP:0010554)1.85742095
127Growth hormone deficiency (HP:0000824)1.84203796
128Enlarged epiphyses (HP:0010580)1.83714920
129Stridor (HP:0010307)1.82442733
130Preaxial hand polydactyly (HP:0001177)1.82347146
131Atrophic scars (HP:0001075)1.82233082
132Shallow orbits (HP:0000586)1.82049521
133Epiphyseal dysplasia (HP:0002656)1.81964249
134Degeneration of anterior horn cells (HP:0002398)1.81931000
135Abnormality of the anterior horn cell (HP:0006802)1.81931000
136Atonic seizures (HP:0010819)1.81925410
137Heterochromia iridis (HP:0001100)1.81733245
138Papillary thyroid carcinoma (HP:0002895)1.81656473
139Abnormality of the lower motor neuron (HP:0002366)1.81000622
140Abnormality of the vitreous humor (HP:0004327)1.79991255
141Small hand (HP:0200055)1.79683232
142Slender build (HP:0001533)1.79547345
143Abnormality of the middle phalanges of the toes (HP:0010183)1.78975549
144Dysmetria (HP:0001310)1.78941728
145Chronic hepatic failure (HP:0100626)1.78756598
146Difficulty walking (HP:0002355)1.78523382
147Urinary urgency (HP:0000012)1.77025511
148Broad alveolar ridges (HP:0000187)1.76461341
149Medulloblastoma (HP:0002885)1.76448859
150Action tremor (HP:0002345)1.76367656
151Glioma (HP:0009733)1.75429980
152Decreased testicular size (HP:0008734)1.75416890
153Clonus (HP:0002169)1.74295903
154Abnormality of dentin (HP:0010299)1.74096087
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73543658
156Anophthalmia (HP:0000528)1.72482061
157Premature rupture of membranes (HP:0001788)1.72301989
158Progressive inability to walk (HP:0002505)1.71745914
159Optic nerve hypoplasia (HP:0000609)1.71624548
160Absent eyebrow (HP:0002223)1.71563311
161Limb dystonia (HP:0002451)1.70986563
162Hypoplastic pelvis (HP:0008839)1.70112435
163Hammertoe (HP:0001765)1.70038870
164Disinhibition (HP:0000734)1.70021302
165Cupped ear (HP:0000378)1.69453513
166Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69365937
167Mixed hearing impairment (HP:0000410)1.68689465
168Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68552625
169Abnormality of alanine metabolism (HP:0010916)1.68552625
170Hyperalaninemia (HP:0003348)1.68552625
171Subacute progressive viral hepatitis (HP:0006572)1.67900118
172Keratoconus (HP:0000563)1.67185794
173Increased corneal curvature (HP:0100692)1.67185794
174Poor coordination (HP:0002370)1.66922182
175Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66307609
176Type 1 muscle fiber predominance (HP:0003803)1.65684820
177Limb-girdle muscle weakness (HP:0003325)1.64108741
178Tented upper lip vermilion (HP:0010804)1.61887811
179Turricephaly (HP:0000262)1.60027927
180Pterygium (HP:0001059)1.58838546
181Scapular winging (HP:0003691)1.57368270
182Arterial tortuosity (HP:0005116)1.57317193
183Pachygyria (HP:0001302)1.56048220
184Non-midline cleft lip (HP:0100335)1.55674515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.95397237
2TRIM283.58364364
3OXSR13.56546116
4WNK42.82929678
5EPHB12.68627667
6CSNK1A1L2.52081060
7TSSK62.49707329
8MAP4K22.46278529
9MAP3K42.38350238
10CSNK1G32.36859157
11MKNK22.16212260
12MET2.15538189
13MKNK12.14589936
14ERBB32.11294213
15CSNK1G21.99846514
16MAPKAPK51.98070825
17CASK1.97808891
18TIE11.96835942
19CSNK1G11.94017864
20LATS11.88080806
21BCR1.88040533
22NTRK11.87363584
23MARK11.85584292
24UHMK11.85270967
25WNK11.81488558
26LIMK11.80844426
27BUB11.79135195
28PAK61.72599182
29PLK31.70214973
30SRPK11.69524379
31CAMK1G1.66966862
32PLK21.66282788
33MAP2K71.64273521
34FGFR21.63802576
35PKN11.57807137
36PNCK1.55328038
37FER1.49693166
38DDR21.48181727
39PRPF4B1.46452994
40SGK4941.45196980
41SGK2231.45196980
42EIF2AK31.44433417
43PDK21.39807362
44TTK1.31482454
45MAP3K21.31340586
46NUAK11.30830153
47TYRO31.28070826
48KSR21.27923580
49ROCK21.27173221
50PAK31.25827492
51WEE11.25116652
52CAMK2B1.24580391
53MAP3K121.21792770
54PIK3CG1.20685453
55EPHA31.15510752
56EPHB21.13946225
57TNIK1.13944682
58NEK61.13367486
59PBK1.12151872
60ZAK1.09670916
61STK38L1.07431510
62PRKD31.07400148
63MAPK151.06892704
64WNK31.05011910
65NTRK21.04657428
66MUSK1.02521248
67CDK191.02099749
68MARK21.02097586
69EPHA41.01673943
70BCKDK0.97824636
71PDGFRB0.97803364
72FES0.97287264
73CDK50.95512735
74CAMK2D0.95223656
75CAMK2G0.93258086
76SIK10.92212186
77BRD40.91620678
78PLK40.90668034
79PRKD10.90552626
80FGR0.88519556
81DYRK20.87923410
82PRKCE0.85644282
83ACVR1B0.84580686
84PRKCG0.84204054
85CAMKK20.84129530
86KSR10.82166913
87PTK20.81272699
88MAPK130.81179576
89NEK10.80996568
90ICK0.79845451
91STK30.79471668
92RET0.79348403
93ARAF0.78608425
94TGFBR10.76677709
95PDGFRA0.75283299
96PLK10.71571085
97SIK30.70654490
98MAP3K90.67191311
99FLT30.66088667
100CAMK2A0.65511498
101PIK3CA0.65254031
102CLK10.65126378
103CAMK1D0.64680722
104DYRK1A0.64399794
105VRK10.63397731
106CDK140.63190629
107MAP2K40.61871310
108TESK20.61455359
109INSRR0.60826224
110CCNB10.60649046
111TRPM70.59615352
112MAP2K20.59403769
113TESK10.58997263
114MST40.58996276
115RPS6KA40.58372416
116NTRK30.58249853
117EIF2AK20.58023586
118BRSK20.57934390
119MINK10.57616588
120CDK150.56636602
121DYRK30.56453691
122ERBB40.55789192
123IRAK20.54894821
124GRK10.54861600
125MATK0.54542665
126CDK180.54405572
127ATR0.53653839
128ROCK10.53188605
129PRKCH0.52122098
130PHKG10.50219286
131PHKG20.50219286
132FRK0.48563477
133CDK11A0.48215688
134HIPK20.48212952
135FYN0.48015906
136CSNK1D0.47481492
137CSNK1A10.45706502
138PTK60.45473011
139LATS20.45398434
140PAK20.45304126
141ATM0.44710783
142PRKG10.44372145
143ADRBK20.44040368
144PRKACB0.40731419
145GSK3A0.39977868
146BMPR1B0.39976074
147EIF2AK10.38922827
148BMX0.37027826
149FGFR10.36443903
150PDPK10.36388506
151CDK90.35071181
152STK160.34983085
153ERBB20.34817179
154CSNK1E0.34642086

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.54725935
2Steroid biosynthesis_Homo sapiens_hsa001003.01673615
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76555548
4Non-homologous end-joining_Homo sapiens_hsa034502.41632374
5Propanoate metabolism_Homo sapiens_hsa006402.29470574
6Fatty acid elongation_Homo sapiens_hsa000622.27965965
7Proteasome_Homo sapiens_hsa030502.26832448
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08329137
9Axon guidance_Homo sapiens_hsa043601.95614659
10Ether lipid metabolism_Homo sapiens_hsa005651.93361249
11Basal transcription factors_Homo sapiens_hsa030221.91137627
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72972227
13Protein export_Homo sapiens_hsa030601.64866345
14Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.61961238
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58059803
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57556343
17Glutamatergic synapse_Homo sapiens_hsa047241.53986316
18Cocaine addiction_Homo sapiens_hsa050301.52504476
19Vibrio cholerae infection_Homo sapiens_hsa051101.49283635
20Sphingolipid metabolism_Homo sapiens_hsa006001.49281420
21Base excision repair_Homo sapiens_hsa034101.47225699
22Phototransduction_Homo sapiens_hsa047441.46944183
23Fanconi anemia pathway_Homo sapiens_hsa034601.46376829
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44023135
25Long-term depression_Homo sapiens_hsa047301.42467064
26Oxidative phosphorylation_Homo sapiens_hsa001901.38701950
27Circadian entrainment_Homo sapiens_hsa047131.36942296
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36655549
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34131963
30Oocyte meiosis_Homo sapiens_hsa041141.32862077
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31688411
32RNA transport_Homo sapiens_hsa030131.31272463
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27024110
34Renal cell carcinoma_Homo sapiens_hsa052111.25264084
35Tight junction_Homo sapiens_hsa045301.25151689
36GABAergic synapse_Homo sapiens_hsa047271.24813238
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23414442
38ECM-receptor interaction_Homo sapiens_hsa045121.22300547
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21919961
40Serotonergic synapse_Homo sapiens_hsa047261.20826491
41Salivary secretion_Homo sapiens_hsa049701.18396288
42Parkinsons disease_Homo sapiens_hsa050121.18166335
43Cholinergic synapse_Homo sapiens_hsa047251.17983072
44Dopaminergic synapse_Homo sapiens_hsa047281.17840650
45Gastric acid secretion_Homo sapiens_hsa049711.15634074
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15362192
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.15185813
48Mismatch repair_Homo sapiens_hsa034301.15085586
49Synaptic vesicle cycle_Homo sapiens_hsa047211.14722785
50mRNA surveillance pathway_Homo sapiens_hsa030151.13718480
51RNA polymerase_Homo sapiens_hsa030201.13704843
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12830770
53Insulin secretion_Homo sapiens_hsa049111.11417792
54Amphetamine addiction_Homo sapiens_hsa050311.09015331
55RNA degradation_Homo sapiens_hsa030181.08513342
56Renin secretion_Homo sapiens_hsa049241.07876469
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07519594
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07249394
59Gap junction_Homo sapiens_hsa045401.06684069
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06221683
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.05280059
62ErbB signaling pathway_Homo sapiens_hsa040121.05205668
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03145759
64Butanoate metabolism_Homo sapiens_hsa006501.02595579
65Endometrial cancer_Homo sapiens_hsa052131.01931906
66TGF-beta signaling pathway_Homo sapiens_hsa043501.01720833
67Sphingolipid signaling pathway_Homo sapiens_hsa040711.01286275
68Morphine addiction_Homo sapiens_hsa050321.00617932
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00236856
70Collecting duct acid secretion_Homo sapiens_hsa049660.99226621
71Fatty acid metabolism_Homo sapiens_hsa012120.98957524
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.98884026
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97032084
74* Sulfur metabolism_Homo sapiens_hsa009200.96930628
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94520349
76Nicotine addiction_Homo sapiens_hsa050330.93048574
77Hedgehog signaling pathway_Homo sapiens_hsa043400.92905873
78Peroxisome_Homo sapiens_hsa041460.92824211
79Basal cell carcinoma_Homo sapiens_hsa052170.90669167
80Pyruvate metabolism_Homo sapiens_hsa006200.90284601
81Protein digestion and absorption_Homo sapiens_hsa049740.89921452
82Hippo signaling pathway_Homo sapiens_hsa043900.89580040
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89565526
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.89210268
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88799690
86Spliceosome_Homo sapiens_hsa030400.88755239
87Pancreatic secretion_Homo sapiens_hsa049720.87890408
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87452470
89Endocytosis_Homo sapiens_hsa041440.87391963
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.86619943
91Thyroid hormone synthesis_Homo sapiens_hsa049180.85746997
92Huntingtons disease_Homo sapiens_hsa050160.84878580
93Focal adhesion_Homo sapiens_hsa045100.84869169
94beta-Alanine metabolism_Homo sapiens_hsa004100.84278857
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84012641
96Estrogen signaling pathway_Homo sapiens_hsa049150.82237885
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80531176
98Ras signaling pathway_Homo sapiens_hsa040140.80333458
99Long-term potentiation_Homo sapiens_hsa047200.79559712
100Melanogenesis_Homo sapiens_hsa049160.78867983
101cAMP signaling pathway_Homo sapiens_hsa040240.75842666
102Wnt signaling pathway_Homo sapiens_hsa043100.75755956
103Linoleic acid metabolism_Homo sapiens_hsa005910.75733055
104Carbon metabolism_Homo sapiens_hsa012000.74777555
105Cell cycle_Homo sapiens_hsa041100.74475698
106Glutathione metabolism_Homo sapiens_hsa004800.72457638
107Histidine metabolism_Homo sapiens_hsa003400.71814213
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71757514
109Regulation of autophagy_Homo sapiens_hsa041400.71566160
110Biosynthesis of amino acids_Homo sapiens_hsa012300.71321465
111Glioma_Homo sapiens_hsa052140.71185600
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70260568
113Choline metabolism in cancer_Homo sapiens_hsa052310.69185095
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69001407
115Tryptophan metabolism_Homo sapiens_hsa003800.68692626
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68169250
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67785866
118Colorectal cancer_Homo sapiens_hsa052100.67721823
119Taste transduction_Homo sapiens_hsa047420.67615918
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67299394
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65308385
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65068372
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64779534
124Lysosome_Homo sapiens_hsa041420.64539760
125Homologous recombination_Homo sapiens_hsa034400.64462542
126Ovarian steroidogenesis_Homo sapiens_hsa049130.64178144
127Type II diabetes mellitus_Homo sapiens_hsa049300.63582349
128Mineral absorption_Homo sapiens_hsa049780.63422763
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62918230
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62746247
131Oxytocin signaling pathway_Homo sapiens_hsa049210.62648398
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62240874
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62032407
134Pancreatic cancer_Homo sapiens_hsa052120.61892146
135Amoebiasis_Homo sapiens_hsa051460.61730748
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61178113
137Dorso-ventral axis formation_Homo sapiens_hsa043200.61085557
138Olfactory transduction_Homo sapiens_hsa047400.60469315
139Alzheimers disease_Homo sapiens_hsa050100.59989559
140Rap1 signaling pathway_Homo sapiens_hsa040150.59459827
141Phagosome_Homo sapiens_hsa041450.59048535
142N-Glycan biosynthesis_Homo sapiens_hsa005100.57815098
143Nitrogen metabolism_Homo sapiens_hsa009100.54612344
144Adherens junction_Homo sapiens_hsa045200.54360990
145GnRH signaling pathway_Homo sapiens_hsa049120.53826001
146Prostate cancer_Homo sapiens_hsa052150.53796999
147Nucleotide excision repair_Homo sapiens_hsa034200.53150389
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52605261
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52514281
150* Metabolic pathways_Homo sapiens_hsa011000.51748979
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51080857
152Arginine and proline metabolism_Homo sapiens_hsa003300.49299506
153* Purine metabolism_Homo sapiens_hsa002300.46522599
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43296078
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42261590

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