PAQR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.39511804
2axon ensheathment in central nervous system (GO:0032291)6.39511804
3GDP-mannose metabolic process (GO:0019673)5.05434727
4DNA unwinding involved in DNA replication (GO:0006268)4.82444546
5proline biosynthetic process (GO:0006561)4.65806764
6adenine nucleotide transport (GO:0051503)4.62726243
7axon ensheathment (GO:0008366)4.27646445
8ensheathment of neurons (GO:0007272)4.27646445
9myelination (GO:0042552)4.23765870
10mitotic chromosome condensation (GO:0007076)4.23114247
11neuronal action potential propagation (GO:0019227)4.21249156
12regulation of mammary gland epithelial cell proliferation (GO:0033599)4.17317058
13regulation of translational fidelity (GO:0006450)4.17099699
14adenosine receptor signaling pathway (GO:0001973)4.15162451
15synaptic vesicle maturation (GO:0016188)4.09665776
16purine nucleotide transport (GO:0015865)4.06716017
17protein retention in ER lumen (GO:0006621)4.01064093
18DNA strand elongation involved in DNA replication (GO:0006271)3.96560941
19cellular potassium ion homeostasis (GO:0030007)3.93166582
20DNA strand elongation (GO:0022616)3.91788700
21fatty acid elongation (GO:0030497)3.86416330
22purine ribonucleotide transport (GO:0015868)3.86078096
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.84862721
24neuron cell-cell adhesion (GO:0007158)3.83493205
25sodium ion export (GO:0071436)3.74063614
26locomotory exploration behavior (GO:0035641)3.72960610
27DNA replication checkpoint (GO:0000076)3.69683864
28regulation of short-term neuronal synaptic plasticity (GO:0048172)3.65915052
29DNA strand renaturation (GO:0000733)3.64695257
30synaptic vesicle exocytosis (GO:0016079)3.64351746
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.64312228
32establishment of mitochondrion localization (GO:0051654)3.63738281
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.62043965
34L-amino acid import (GO:0043092)3.60969295
35potassium ion import (GO:0010107)3.58625093
36folic acid metabolic process (GO:0046655)3.55193763
37regulation of synaptic vesicle exocytosis (GO:2000300)3.46505050
38protein insertion into membrane (GO:0051205)3.45964297
39peptidyl-tyrosine autophosphorylation (GO:0038083)3.43867043
40telomere maintenance via semi-conservative replication (GO:0032201)3.43260811
41DNA replication initiation (GO:0006270)3.42799898
42vocalization behavior (GO:0071625)3.42249049
43glutamate secretion (GO:0014047)3.41630704
44transmission of nerve impulse (GO:0019226)3.41202497
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39945211
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.37297330
47UV protection (GO:0009650)3.37139453
48positive regulation of synapse maturation (GO:0090129)3.35011928
49protein localization to synapse (GO:0035418)3.30258897
50proline metabolic process (GO:0006560)3.28503405
51adult walking behavior (GO:0007628)3.26480747
52photoreceptor cell differentiation (GO:0046530)3.25828023
53eye photoreceptor cell differentiation (GO:0001754)3.25828023
54negative regulation of cell size (GO:0045792)3.24293428
55meiotic chromosome segregation (GO:0045132)3.21552166
56gamma-aminobutyric acid transport (GO:0015812)3.21369445
57presynaptic membrane organization (GO:0097090)3.19877065
58presynaptic membrane assembly (GO:0097105)3.19594190
59negative regulation of protein localization to cell surface (GO:2000009)3.19467573
60long-chain fatty acid biosynthetic process (GO:0042759)3.15111449
61potassium ion homeostasis (GO:0055075)3.14943709
62Golgi transport vesicle coating (GO:0048200)3.14005609
63COPI coating of Golgi vesicle (GO:0048205)3.14005609
64negative regulation of neurotransmitter transport (GO:0051589)3.13104786
65peptidyl-arginine omega-N-methylation (GO:0035247)3.10931275
66layer formation in cerebral cortex (GO:0021819)3.08540978
67semaphorin-plexin signaling pathway (GO:0071526)3.07779111
68mitotic nuclear envelope reassembly (GO:0007084)3.07198406
69nuclear envelope reassembly (GO:0031468)3.07198406
70glycine transport (GO:0015816)3.04880053
71melanin biosynthetic process (GO:0042438)3.04482995
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04400508
73positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.03191200
74negative regulation of neurotransmitter secretion (GO:0046929)3.02226749
75cytoskeletal anchoring at plasma membrane (GO:0007016)3.00933747
76detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.00805146
77detection of temperature stimulus involved in sensory perception (GO:0050961)3.00805146
78negative regulation of cell aging (GO:0090344)3.00481880
79neuronal ion channel clustering (GO:0045161)2.99910445
80amino acid import (GO:0043090)2.99887369
81regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98199530
82protein localization to endosome (GO:0036010)2.97363136
83regulation of voltage-gated calcium channel activity (GO:1901385)2.96863727
84regulation of cholesterol biosynthetic process (GO:0045540)2.96620569
85intracellular estrogen receptor signaling pathway (GO:0030520)2.96098293
86dendritic spine morphogenesis (GO:0060997)2.95511467
87regulation of synaptic vesicle transport (GO:1902803)2.95251214
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93263387
89protein complex localization (GO:0031503)2.92858410
90neuron recognition (GO:0008038)2.92506928
91cerebellar granule cell differentiation (GO:0021707)2.91815579
92membrane hyperpolarization (GO:0060081)2.89367969
93oligodendrocyte differentiation (GO:0048709)2.88827561
94regulation of neuronal synaptic plasticity (GO:0048168)2.88817189
95ionotropic glutamate receptor signaling pathway (GO:0035235)2.87329419
96retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87060452
97dendrite morphogenesis (GO:0048813)2.86811844
98regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.86807521
99apical protein localization (GO:0045176)2.86428335
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85867133
101substantia nigra development (GO:0021762)2.85034360
102positive regulation of potassium ion transmembrane transport (GO:1901381)2.84828225
103spliceosomal tri-snRNP complex assembly (GO:0000244)2.83803803
104regulation of synapse structural plasticity (GO:0051823)2.83217927
105mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.83216720
106negative regulation of axonogenesis (GO:0050771)2.83005983
107myelin maintenance (GO:0043217)2.82176966
108glutamate receptor signaling pathway (GO:0007215)2.80830074
109response to auditory stimulus (GO:0010996)2.80114028
110DNA duplex unwinding (GO:0032508)2.79005692
111regulation of long-term neuronal synaptic plasticity (GO:0048169)2.77890320
112negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.77004293
113neurotransmitter uptake (GO:0001504)2.76944477
114myelination in peripheral nervous system (GO:0022011)2.76926265
115peripheral nervous system axon ensheathment (GO:0032292)2.76926265
116positive regulation of potassium ion transport (GO:0043268)2.76263382
117protein-DNA complex disassembly (GO:0032986)2.76082003
118nucleosome disassembly (GO:0006337)2.76082003
119melanin metabolic process (GO:0006582)2.75588270
120mitotic sister chromatid segregation (GO:0000070)2.75540344
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74152660
122exploration behavior (GO:0035640)2.73631838
123histone phosphorylation (GO:0016572)2.73249669
124positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.72749143
125regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.72749143
126detection of temperature stimulus (GO:0016048)2.71754115
127adherens junction assembly (GO:0034333)2.70796691
128regulation of mitotic spindle organization (GO:0060236)2.70759207
129activation of Rac GTPase activity (GO:0032863)2.70222768
130mitotic G1 DNA damage checkpoint (GO:0031571)2.70194682
131neuromuscular process controlling posture (GO:0050884)2.70165859
132neurotransmitter secretion (GO:0007269)2.69949797
133positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69632057
134negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.69516745
135cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.69252156
136sensory perception of taste (GO:0050909)2.67509267
137maternal placenta development (GO:0001893)2.67483312
138mitochondrion transport along microtubule (GO:0047497)2.66877024
139establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.66877024
140synaptic transmission, glutamatergic (GO:0035249)2.66625113
141neuron-neuron synaptic transmission (GO:0007270)2.66282464
142negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65585554
143axonal fasciculation (GO:0007413)2.65436275
144cell migration in hindbrain (GO:0021535)2.65145032
145cell communication by electrical coupling (GO:0010644)2.64440036
146cellular response to ATP (GO:0071318)2.64412811
147astrocyte development (GO:0014002)2.64370958
148glycerophospholipid catabolic process (GO:0046475)2.64357197
149glucocorticoid receptor signaling pathway (GO:0042921)2.63915842
150cell-substrate adherens junction assembly (GO:0007045)2.63235235
151focal adhesion assembly (GO:0048041)2.63235235
152membrane assembly (GO:0071709)2.63143930
153positive regulation of membrane potential (GO:0045838)2.63017572
154regulation of collateral sprouting (GO:0048670)2.62416826
155regulation of NFAT protein import into nucleus (GO:0051532)2.61948479
156neurotransmitter transport (GO:0006836)2.61495196
157negative regulation of axon extension (GO:0030517)2.61308285
158cellular sodium ion homeostasis (GO:0006883)2.61016409
159cerebral cortex radially oriented cell migration (GO:0021799)2.60771542
160regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59850320
161cellular protein complex localization (GO:0034629)2.59594564
162gamma-aminobutyric acid signaling pathway (GO:0007214)2.58924507
163peptidyl-arginine N-methylation (GO:0035246)2.58398458
164peptidyl-arginine methylation (GO:0018216)2.58398458
165nucleobase-containing small molecule interconversion (GO:0015949)2.57735147
166L-serine transport (GO:0015825)2.57130184
167regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56311664
168apoptotic process involved in morphogenesis (GO:0060561)2.56082891
169negative regulation of microtubule polymerization (GO:0031115)2.55001277
170asymmetric protein localization (GO:0008105)2.54497656
171DNA geometric change (GO:0032392)2.54425744
172positive regulation of sodium ion transmembrane transport (GO:1902307)2.54132623
173regulation of glutamate receptor signaling pathway (GO:1900449)2.52241733
174L-serine metabolic process (GO:0006563)2.52177176
175positive regulation of action potential (GO:0045760)2.50148824
176telomere maintenance via recombination (GO:0000722)2.47745952
177regulation of glucose import in response to insulin stimulus (GO:2001273)2.42694511
178regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.41716261
179positive regulation of protein sumoylation (GO:0033235)2.39280116
180G1 DNA damage checkpoint (GO:0044783)2.38262197
181sister chromatid segregation (GO:0000819)2.38252071
182histone arginine methylation (GO:0034969)2.37340771
183chromosome condensation (GO:0030261)2.36603338
184rRNA methylation (GO:0031167)2.35742630
185rRNA transcription (GO:0009303)2.35694147
186RNA stabilization (GO:0043489)2.33966028
187mRNA stabilization (GO:0048255)2.33966028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.97548929
2EZH2_22144423_ChIP-Seq_EOC_Human4.36220361
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.23055263
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13565205
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05717397
6* VDR_21846776_ChIP-Seq_THP-1_Human2.99901930
7GBX2_23144817_ChIP-Seq_PC3_Human2.89157211
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87643218
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87643218
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.74184271
11* LXR_22292898_ChIP-Seq_THP-1_Human2.73732864
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71697457
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71516824
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.69685856
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66296813
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.61782930
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59689751
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57054865
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55789880
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.51297389
21MYC_22102868_ChIP-Seq_BL_Human2.47047650
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.44889150
23DROSHA_22980978_ChIP-Seq_HELA_Human2.40132044
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38700390
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34625775
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24080008
27AR_21572438_ChIP-Seq_LNCaP_Human2.23346582
28* RACK7_27058665_Chip-Seq_MCF-7_Human2.23064581
29* RNF2_27304074_Chip-Seq_ESCs_Mouse2.18149316
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.12494207
31REST_21632747_ChIP-Seq_MESCs_Mouse2.09117414
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07823995
33RARB_27405468_Chip-Seq_BRAIN_Mouse2.06177079
34XRN2_22483619_ChIP-Seq_HELA_Human2.03260140
35* P68_20966046_ChIP-Seq_HELA_Human2.00724225
36ZNF263_19887448_ChIP-Seq_K562_Human1.97724284
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97375326
38* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92734713
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.84313203
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.83034193
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.81457273
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79525942
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76818313
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.76142894
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74331895
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74027845
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73552974
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73374574
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73123320
50KDM2B_26808549_Chip-Seq_DND41_Human1.72624286
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72271537
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.69110504
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68731736
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64662348
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64484437
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61729515
57* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.60844604
58TCF7_22412390_ChIP-Seq_EML_Mouse1.58021575
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57368848
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57000256
61* SMC4_20622854_ChIP-Seq_HELA_Human1.56473819
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50033362
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.48548870
64* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47468175
65* RING1B_27294783_Chip-Seq_ESCs_Mouse1.46788633
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45782259
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43890796
68* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43750717
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.42010950
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41081584
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.40926043
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40869059
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40009660
74MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.38078006
75* CREB1_26743006_Chip-Seq_LNCaP_Human1.37332265
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35722469
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35171137
78* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34522655
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32120139
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31151874
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.30905906
82MAF_26560356_Chip-Seq_TH2_Human1.30789494
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30230273
84MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29835176
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28366891
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28060949
87BCOR_27268052_Chip-Seq_Bcells_Human1.26351552
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26029737
89TAF15_26573619_Chip-Seq_HEK293_Human1.25740638
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25354454
91TRIM28_21343339_ChIP-Seq_HEK293_Human1.25113816
92* FOXP1_21924763_ChIP-Seq_HESCs_Human1.23746617
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.23348830
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23255068
95* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22033645
96* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.21900223
97* RARA_24833708_ChIP-Seq_LIVER_Mouse1.21598243
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21165034
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20821651
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20546904
101RARB_24833708_ChIP-Seq_LIVER_Mouse1.20486748
102DCP1A_22483619_ChIP-Seq_HELA_Human1.20052956
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19689215
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18832160
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18302375
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17742438
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17516970
108VDR_24763502_ChIP-Seq_THP-1_Human1.15778738
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.15653817
110PHF8_20622854_ChIP-Seq_HELA_Human1.15500123
111BCL6_27268052_Chip-Seq_Bcells_Human1.15456234
112NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15036693
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.14933549
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14863452
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.14650840
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14449778
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13551848
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13185521
119* KDM2B_26808549_Chip-Seq_K562_Human1.12534913
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12149231
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11888748
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11477016
123SMAD4_21799915_ChIP-Seq_A2780_Human1.10313716
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10186347
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09710109
126* ATF3_27146783_Chip-Seq_COLON_Human1.08906182
127* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08243160
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07830268
129ETS1_21867929_ChIP-Seq_TH2_Mouse1.07596309
130MAF_26560356_Chip-Seq_TH1_Human1.07221358
131RUNX1_27514584_Chip-Seq_MCF-7_Human1.06648781
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06546575
133CTCF_27219007_Chip-Seq_Bcells_Human1.05765942
134PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05204197
135E2F1_20622854_ChIP-Seq_HELA_Human1.04735731
136* E2F1_21310950_ChIP-Seq_MCF-7_Human1.03905225
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03830805
138GABP_19822575_ChIP-Seq_HepG2_Human1.03750039
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03454479
140ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03180152
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02969853
142* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02950232
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02889094
144CTCF_21964334_Chip-Seq_Bcells_Human1.02026406
145ESR2_21235772_ChIP-Seq_MCF-7_Human1.01741282
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01326935
147TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01229740
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01122431
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01067297
150ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00718357
151P300_19829295_ChIP-Seq_ESCs_Human0.99637606
152EP300_21415370_ChIP-Seq_HL-1_Mouse0.99031670
153RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98905825
154TET1_21490601_ChIP-Seq_MESCs_Mouse0.98200244
155BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97966068
156EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97133283
157PRDM14_20953172_ChIP-Seq_ESCs_Human0.96930683
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.96277175
159AR_19668381_ChIP-Seq_PC3_Human0.95852631
160AHR_22903824_ChIP-Seq_MCF-7_Human0.94738727
161SOX2_21211035_ChIP-Seq_LN229_Gbm0.94677545
162STAT3_23295773_ChIP-Seq_U87_Human0.93747802
163ZNF274_21170338_ChIP-Seq_K562_Hela0.92087474
164TP53_20018659_ChIP-ChIP_R1E_Mouse0.90660420
165AR_25329375_ChIP-Seq_VCAP_Human0.88800668
166GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88405620
167SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87640874
168ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87477556
169ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87309675
170SMAD4_21741376_ChIP-Seq_HESCs_Human0.86475266
171ARNT_22903824_ChIP-Seq_MCF-7_Human0.86283484
172MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86152698
173CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86013516
174VDR_22108803_ChIP-Seq_LS180_Human0.85707282
175* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83443628
176ER_23166858_ChIP-Seq_MCF-7_Human0.82044099
177ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81490753
178NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81160356
179SMAD3_21741376_ChIP-Seq_ESCs_Human0.80842438
180CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79715963
181SMAD3_21741376_ChIP-Seq_HESCs_Human0.79566254
182TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79487842
183RUNX2_22187159_ChIP-Seq_PCA_Human0.78613460
184GATA1_26923725_Chip-Seq_HPCs_Mouse0.77801197
185RNF2_27304074_Chip-Seq_NSC_Mouse0.77721543
186TCF4_23295773_ChIP-Seq_U87_Human0.77436185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.32529310
2MP0003880_abnormal_central_pattern4.00138232
3MP0004270_analgesia3.97814559
4MP0003705_abnormal_hypodermis_morpholog3.49387404
5MP0003111_abnormal_nucleus_morphology3.16864613
6MP0000920_abnormal_myelination3.09965620
7MP0003635_abnormal_synaptic_transmissio3.03132230
8MP0001188_hyperpigmentation2.95731925
9MP0005423_abnormal_somatic_nervous2.77123042
10MP0002272_abnormal_nervous_system2.74838633
11MP0002064_seizures2.68799889
12MP0001968_abnormal_touch/_nociception2.61988198
13MP0003329_amyloid_beta_deposits2.61330449
14MP0002734_abnormal_mechanical_nocicepti2.58776353
15MP0001486_abnormal_startle_reflex2.58388509
16MP0004885_abnormal_endolymph2.53618482
17MP0009745_abnormal_behavioral_response2.49490588
18MP0005076_abnormal_cell_differentiation2.47804610
19MP0009046_muscle_twitch2.39850000
20MP0010094_abnormal_chromosome_stability2.35984379
21MP0003690_abnormal_glial_cell2.27839774
22MP0002063_abnormal_learning/memory/cond2.26976319
23MP0010234_abnormal_vibrissa_follicle2.18286925
24MP0000778_abnormal_nervous_system2.15733430
25MP0002736_abnormal_nociception_after2.11612931
26MP0003693_abnormal_embryo_hatching2.11500583
27MP0002877_abnormal_melanocyte_morpholog2.09903351
28MP0005174_abnormal_tail_pigmentation2.07935446
29MP0005551_abnormal_eye_electrophysiolog2.07047864
30MP0002572_abnormal_emotion/affect_behav2.06673098
31MP0001346_abnormal_lacrimal_gland2.02190083
32MP0002733_abnormal_thermal_nociception2.01567704
33MP0003634_abnormal_glial_cell1.97956418
34MP0003950_abnormal_plasma_membrane1.94748283
35MP0001970_abnormal_pain_threshold1.88658883
36MP0004858_abnormal_nervous_system1.87915586
37MP0003453_abnormal_keratinocyte_physiol1.87809141
38MP0008569_lethality_at_weaning1.86512011
39MP0004957_abnormal_blastocyst_morpholog1.86363524
40MP0002067_abnormal_sensory_capabilities1.84855173
41MP0001440_abnormal_grooming_behavior1.84136909
42MP0001529_abnormal_vocalization1.83981311
43MP0005058_abnormal_lysosome_morphology1.79940920
44MP0003077_abnormal_cell_cycle1.79068421
45MP0004381_abnormal_hair_follicle1.78749801
46MP0002229_neurodegeneration1.74973946
47MP0004142_abnormal_muscle_tone1.74003182
48MP0001485_abnormal_pinna_reflex1.73686826
49MP0001905_abnormal_dopamine_level1.73568956
50MP0002735_abnormal_chemical_nociception1.72854632
51MP0005501_abnormal_skin_physiology1.72359292
52MP0002882_abnormal_neuron_morphology1.65462291
53MP0004742_abnormal_vestibular_system1.62319413
54MP0000955_abnormal_spinal_cord1.61969720
55MP0002249_abnormal_larynx_morphology1.60529986
56MP0000751_myopathy1.54088830
57MP0000462_abnormal_digestive_system1.52821740
58MP0002822_catalepsy1.50118419
59MP0004233_abnormal_muscle_weight1.46061281
60MP0003123_paternal_imprinting1.45758108
61MP0001501_abnormal_sleep_pattern1.45755607
62MP0001849_ear_inflammation1.45329703
63MP0004924_abnormal_behavior1.44965217
64MP0005386_behavior/neurological_phenoty1.44965217
65MP0005451_abnormal_body_composition1.43980073
66MP0005171_absent_coat_pigmentation1.43793235
67MP0002066_abnormal_motor_capabilities/c1.40343263
68MP0000678_abnormal_parathyroid_gland1.40258352
69MP0008932_abnormal_embryonic_tissue1.37857525
70MP0006276_abnormal_autonomic_nervous1.37192940
71MP0002796_impaired_skin_barrier1.35896431
72MP0009278_abnormal_bone_marrow1.35628317
73MP0002184_abnormal_innervation1.34210403
74MP0003632_abnormal_nervous_system1.30309830
75MP0002557_abnormal_social/conspecific_i1.29300640
76MP0003633_abnormal_nervous_system1.29031181
77MP0005253_abnormal_eye_physiology1.28932179
78MP0003631_nervous_system_phenotype1.26381664
79MP0005409_darkened_coat_color1.26145846
80MP0000350_abnormal_cell_proliferation1.25807241
81MP0009672_abnormal_birth_weight1.25153203
82MP0009780_abnormal_chondrocyte_physiolo1.23611357
83MP0002752_abnormal_somatic_nervous1.22071139
84MP0000579_abnormal_nail_morphology1.21827068
85MP0006072_abnormal_retinal_apoptosis1.21748686
86MP0003136_yellow_coat_color1.20750881
87MP0004811_abnormal_neuron_physiology1.18582255
88MP0002089_abnormal_postnatal_growth/wei1.15416010
89MP0001730_embryonic_growth_arrest1.13233847
90MP0000604_amyloidosis1.12559317
91MP0003137_abnormal_impulse_conducting1.12297218
92MP0000015_abnormal_ear_pigmentation1.11082068
93MP0001963_abnormal_hearing_physiology1.10512996
94MP0003011_delayed_dark_adaptation1.08308190
95MP0002152_abnormal_brain_morphology1.04642050
96MP0001299_abnormal_eye_distance/1.03901085
97MP0000750_abnormal_muscle_regeneration1.02731656
98MP0002080_prenatal_lethality1.02061370
99MP0008007_abnormal_cellular_replicative1.01833138
100MP0005623_abnormal_meninges_morphology0.97553483
101MP0005646_abnormal_pituitary_gland0.97546455
102MP0001348_abnormal_lacrimal_gland0.94535899
103MP0001502_abnormal_circadian_rhythm0.94472182
104MP0000566_synostosis0.92918520
105MP0001664_abnormal_digestion0.91185584
106MP0004043_abnormal_pH_regulation0.89527145
107MP0003938_abnormal_ear_development0.88162787
108MP0002909_abnormal_adrenal_gland0.87553810
109MP0010030_abnormal_orbit_morphology0.87206023
110MP0005621_abnormal_cell_physiology0.87087029
111MP0005195_abnormal_posterior_eye0.86729726
112MP0002098_abnormal_vibrissa_morphology0.86440986
113MP0004215_abnormal_myocardial_fiber0.86286250
114MP0010771_integument_phenotype0.86216735
115MP0002090_abnormal_vision0.85207332
116MP0005666_abnormal_adipose_tissue0.84056954
117MP0005375_adipose_tissue_phenotype0.82708882
118MP0000747_muscle_weakness0.79873576
119MP0003879_abnormal_hair_cell0.79287466
120MP0005380_embryogenesis_phenotype0.79057009
121MP0001672_abnormal_embryogenesis/_devel0.79057009
122MP0000026_abnormal_inner_ear0.78071092
123MP0000759_abnormal_skeletal_muscle0.77216376
124MP0001177_atelectasis0.76263681
125MP0005330_cardiomyopathy0.75786924
126MP0004145_abnormal_muscle_electrophysio0.75757979
127MP0004185_abnormal_adipocyte_glucose0.75220274
128MP0000467_abnormal_esophagus_morphology0.74423957
129MP0004087_abnormal_muscle_fiber0.73985171
130MP0004197_abnormal_fetal_growth/weight/0.73643755
131MP0001697_abnormal_embryo_size0.70823059
132MP0005083_abnormal_biliary_tract0.70583969
133MP0000013_abnormal_adipose_tissue0.70467776
134MP0000313_abnormal_cell_death0.70364493
135MP0005384_cellular_phenotype0.70281715
136MP0004147_increased_porphyrin_level0.69027567
137MP0002085_abnormal_embryonic_tissue0.69025858
138MP0001986_abnormal_taste_sensitivity0.68857963
139MP0010678_abnormal_skin_adnexa0.68804287
140MP0003566_abnormal_cell_adhesion0.67504773
141MP0000733_abnormal_muscle_development0.67463205
142MP0009931_abnormal_skin_appearance0.67390333
143MP0000358_abnormal_cell_content/0.67049249
144MP0000377_abnormal_hair_follicle0.66396029
145MP0000681_abnormal_thyroid_gland0.66031138
146MP0002653_abnormal_ependyma_morphology0.65647147
147MP0001984_abnormal_olfaction0.65099991
148MP0003984_embryonic_growth_retardation0.64923855
149MP0004085_abnormal_heartbeat0.64873910
150MP0002837_dystrophic_cardiac_calcinosis0.64638408
151MP0008260_abnormal_autophagy0.64269988
152MP0002069_abnormal_eating/drinking_beha0.64036591
153MP0004130_abnormal_muscle_cell0.60689568
154MP0000631_abnormal_neuroendocrine_gland0.60006342
155MP0000537_abnormal_urethra_morphology0.59917201
156MP0005410_abnormal_fertilization0.59792512
157MP0003115_abnormal_respiratory_system0.59006902
158MP0003283_abnormal_digestive_organ0.58403455
159MP0002088_abnormal_embryonic_growth/wei0.58352712
160MP0003861_abnormal_nervous_system0.58207998
161MP0001943_abnormal_respiration0.55775695
162MP0008872_abnormal_physiological_respon0.55592129
163MP0000003_abnormal_adipose_tissue0.55449253

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.45220856
2Neurofibrillary tangles (HP:0002185)4.89646771
3Ulnar bowing (HP:0003031)4.49326635
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.28379936
5Degeneration of the lateral corticospinal tracts (HP:0002314)4.28379936
6Supranuclear gaze palsy (HP:0000605)4.17546564
7Focal motor seizures (HP:0011153)4.05674735
8Hyperacusis (HP:0010780)4.00159953
9Turricephaly (HP:0000262)3.98226689
10Annular pancreas (HP:0001734)3.90571981
11Cerebral inclusion bodies (HP:0100314)3.78197814
12Abnormality of the corticospinal tract (HP:0002492)3.75237818
13Testicular atrophy (HP:0000029)3.75050814
14Megalencephaly (HP:0001355)3.71765136
15Insidious onset (HP:0003587)3.70916874
16Termporal pattern (HP:0011008)3.70916874
17Thin bony cortex (HP:0002753)3.66543917
18Peripheral hypomyelination (HP:0007182)3.63235885
19Action tremor (HP:0002345)3.56233605
20Ankle clonus (HP:0011448)3.49724716
21Pheochromocytoma (HP:0002666)3.37743855
22Sensory axonal neuropathy (HP:0003390)3.36180991
23Focal seizures (HP:0007359)3.24501260
24Poikiloderma (HP:0001029)3.24498355
25Spastic gait (HP:0002064)3.19209321
26Dysmetria (HP:0001310)3.10812099
27Onion bulb formation (HP:0003383)3.09884167
28Neuroendocrine neoplasm (HP:0100634)3.00115911
29Myopathic facies (HP:0002058)2.92768506
30Aplasia involving bones of the upper limbs (HP:0009823)2.92281146
31Aplasia of the phalanges of the hand (HP:0009802)2.92281146
32Aplasia involving bones of the extremities (HP:0009825)2.92281146
33Cerebral hypomyelination (HP:0006808)2.87163662
34Atonic seizures (HP:0010819)2.86758453
35Vaginal fistula (HP:0004320)2.86304623
36Upper limb amyotrophy (HP:0009129)2.85952131
37Distal upper limb amyotrophy (HP:0007149)2.85952131
38Intention tremor (HP:0002080)2.85944936
39Rib fusion (HP:0000902)2.83796848
40Progressive cerebellar ataxia (HP:0002073)2.82522505
41Scanning speech (HP:0002168)2.79830641
42Intestinal fistula (HP:0100819)2.78977840
43Facial hemangioma (HP:0000329)2.78767279
44Birth length less than 3rd percentile (HP:0003561)2.78436207
45Epileptic encephalopathy (HP:0200134)2.75197008
46Coronal craniosynostosis (HP:0004440)2.71174777
47Retinal dysplasia (HP:0007973)2.70767318
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.68452479
49Achilles tendon contracture (HP:0001771)2.67999309
50Rectovaginal fistula (HP:0000143)2.62253868
51Rectal fistula (HP:0100590)2.62253868
52Split foot (HP:0001839)2.59478001
53Lower limb amyotrophy (HP:0007210)2.54986050
54Progressive muscle weakness (HP:0003323)2.54936540
55Visual hallucinations (HP:0002367)2.52483586
56Dysdiadochokinesis (HP:0002075)2.51566577
57Lower limb muscle weakness (HP:0007340)2.49348469
58Urinary urgency (HP:0000012)2.46774164
59Segmental peripheral demyelination/remyelination (HP:0003481)2.46687317
60Squamous cell carcinoma (HP:0002860)2.43774200
61Choanal stenosis (HP:0000452)2.42568510
62Ulnar claw (HP:0001178)2.41524282
63Broad distal phalanx of finger (HP:0009836)2.39264915
64Cerebral aneurysm (HP:0004944)2.37539012
65Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35834748
66Distal lower limb amyotrophy (HP:0008944)2.35403208
67Urinary bladder sphincter dysfunction (HP:0002839)2.34451535
68Slow saccadic eye movements (HP:0000514)2.33869445
69Abnormal auditory evoked potentials (HP:0006958)2.33556022
70Absence seizures (HP:0002121)2.32701805
71Abnormality of binocular vision (HP:0011514)2.32371259
72Diplopia (HP:0000651)2.32371259
73Fetal akinesia sequence (HP:0001989)2.31584671
74Hand muscle atrophy (HP:0009130)2.30929680
75Generalized tonic-clonic seizures (HP:0002069)2.30774649
76Akinesia (HP:0002304)2.28133504
77Humeroradial synostosis (HP:0003041)2.27884136
78Synostosis involving the elbow (HP:0003938)2.27884136
79Abnormal eating behavior (HP:0100738)2.27329347
80Patellar aplasia (HP:0006443)2.24678985
81Abnormality of the Achilles tendon (HP:0005109)2.24141740
82Central scotoma (HP:0000603)2.22492270
83Alacrima (HP:0000522)2.22432235
84Dialeptic seizures (HP:0011146)2.22116631
85Thin ribs (HP:0000883)2.19277715
86Pointed chin (HP:0000307)2.17147163
87Broad face (HP:0000283)2.16314845
88Truncal ataxia (HP:0002078)2.14914028
89Asymmetry of the thorax (HP:0001555)2.14895214
90Aqueductal stenosis (HP:0002410)2.14574509
91Overriding aorta (HP:0002623)2.14408972
92Anxiety (HP:0000739)2.13769868
93Popliteal pterygium (HP:0009756)2.11177430
94Aplasia/Hypoplasia of the patella (HP:0006498)2.10256938
95Depression (HP:0000716)2.10223307
96Ragged-red muscle fibers (HP:0003200)2.10192084
97Foot dorsiflexor weakness (HP:0009027)2.09589049
98Limb dystonia (HP:0002451)2.08340498
99Congenital stationary night blindness (HP:0007642)2.08298069
100Abnormality of the intrinsic pathway (HP:0010989)2.08089565
101Increased nuchal translucency (HP:0010880)2.07590346
102Ventricular fibrillation (HP:0001663)2.05592381
103Hemiparesis (HP:0001269)2.05378132
104Hemorrhage of the eye (HP:0011885)2.05310250
105Hammertoe (HP:0001765)2.04941919
106Clumsiness (HP:0002312)2.04703755
107Thickened helices (HP:0000391)2.04212499
108Stridor (HP:0010307)2.04119976
109Abnormal gallbladder physiology (HP:0012438)2.03083778
110Cholecystitis (HP:0001082)2.03083778
111Gaze-evoked nystagmus (HP:0000640)2.01216123
112Neoplasm of the peripheral nervous system (HP:0100007)2.01115979
113Diminished movement (HP:0002374)2.00007268
114Insomnia (HP:0100785)1.99819853
115Delayed epiphyseal ossification (HP:0002663)1.99748746
116Bowing of the arm (HP:0006488)1.99720499
117Bowed forearm bones (HP:0003956)1.99720499
118Broad-based gait (HP:0002136)1.99038800
119Elfin facies (HP:0004428)1.98840561
120Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97335691
121Absent epiphyses (HP:0010577)1.97335691
122Ileus (HP:0002595)1.96628244
123Impaired vibration sensation in the lower limbs (HP:0002166)1.96567188
124Mutism (HP:0002300)1.96055257
125Steppage gait (HP:0003376)1.94767597
126Distal lower limb muscle weakness (HP:0009053)1.93956126
127Male infertility (HP:0003251)1.93715324
128Spastic paraparesis (HP:0002313)1.92879996
129Breast hypoplasia (HP:0003187)1.92656797
130Abnormality of the foot musculature (HP:0001436)1.92091345
131Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91976497
132Centrally nucleated skeletal muscle fibers (HP:0003687)1.91420208
133External ophthalmoplegia (HP:0000544)1.90582749
134Parakeratosis (HP:0001036)1.89917112
135Prolonged QT interval (HP:0001657)1.89875945
136Torticollis (HP:0000473)1.89434844
137Leukodystrophy (HP:0002415)1.89322283
138Clonus (HP:0002169)1.88531101
139Obstructive sleep apnea (HP:0002870)1.88356945
140Pterygium (HP:0001059)1.88309654
141Metabolic alkalosis (HP:0200114)1.88191061
142Spina bifida occulta (HP:0003298)1.87000570
143Premature graying of hair (HP:0002216)1.84021389
144Increased circulating renin level (HP:0000848)1.83921763
145Abnormality of macular pigmentation (HP:0008002)1.82574025
146Congenital hip dislocation (HP:0001374)1.81862501
147Absent radius (HP:0003974)1.80469469
148Scotoma (HP:0000575)1.80431893
149Vertebral compression fractures (HP:0002953)1.79662945
150Hemiplegia (HP:0002301)1.79221128
151Decreased motor nerve conduction velocity (HP:0003431)1.77958983
152Hyperparathyroidism (HP:0000843)1.77892280
153Cholelithiasis (HP:0001081)1.77697732
154Generalized myoclonic seizures (HP:0002123)1.77599041
155Cerebral hemorrhage (HP:0001342)1.77509631
156Atrioventricular block (HP:0001678)1.77277591
157J-shaped sella turcica (HP:0002680)1.76905365
158CNS hypomyelination (HP:0003429)1.76768586
159Capillary hemangiomas (HP:0005306)1.76209963
160Hyperventilation (HP:0002883)1.75905680
161Distal sensory impairment (HP:0002936)1.75250517
162Bowel incontinence (HP:0002607)1.75143015
163Abnormality of glycolysis (HP:0004366)1.74725271
164Increased serum pyruvate (HP:0003542)1.74725271
165Bronchomalacia (HP:0002780)1.73571351
166Slow progression (HP:0003677)1.73433667
167Neuronal loss in central nervous system (HP:0002529)1.72886146
168Bony spicule pigmentary retinopathy (HP:0007737)1.72860786
169Multiple enchondromatosis (HP:0005701)1.71990787
170Exercise-induced myalgia (HP:0003738)1.71673220
171Abolished electroretinogram (ERG) (HP:0000550)1.71615016
172Polyphagia (HP:0002591)1.71162052
173Slender long bone (HP:0003100)1.71133305
174Renal duplication (HP:0000075)1.70959269
175Self-mutilation (HP:0000742)1.70833594
176Rapidly progressive (HP:0003678)1.70769789
177Neonatal onset (HP:0003623)1.69593945
178Anteriorly placed anus (HP:0001545)1.69329503
179Abnormal rod and cone electroretinograms (HP:0008323)1.68743379
180Athetosis (HP:0002305)1.67757977
181Absent forearm bone (HP:0003953)1.66527825
182Aplasia involving forearm bones (HP:0009822)1.66527825
183Easy fatigability (HP:0003388)1.65918621
184Abnormal large intestine physiology (HP:0012700)1.65825742
185Flat occiput (HP:0005469)1.65357558
186Selective tooth agenesis (HP:0001592)1.62463635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.34005677
2STK393.92303658
3SMG13.30426852
4EPHA42.83668081
5EEF2K2.63137496
6OXSR12.58603003
7PKN22.47231463
8TNIK2.46431374
9SIK12.45026959
10MARK12.42636121
11LMTK22.39082435
12MAP3K92.30738748
13NTRK12.17362497
14CDK122.14489364
15IRAK32.13363834
16PHKG12.10144462
17PHKG22.10144462
18NTRK32.09968296
19PAK62.09487239
20LIMK11.97588419
21MINK11.95087408
22CDC71.94694208
23KSR21.91156153
24EPHA21.82379396
25CDK191.81710616
26NME21.81168207
27CASK1.81136538
28MAPK151.78028120
29UHMK11.75094124
30TESK11.68086276
31EPHB11.65587572
32PRKD31.62020394
33PKN11.61531987
34SCYL21.60338512
35NTRK21.56584803
36WNK11.56299790
37ARAF1.55727344
38MAP3K41.54881493
39SIK21.54054071
40BCR1.50117048
41FGFR21.47221781
42PRPF4B1.45575784
43ROCK21.44524004
44TYRO31.44081722
45WNK41.42862156
46MST1R1.40566329
47MAP3K101.39331115
48CDK51.38205337
49ERN11.35684056
50PNCK1.34543806
51TLK11.34242384
52MAP2K71.26381408
53CAMK2B1.26079404
54MAPK131.25907831
55CDK141.25832459
56SGK2231.25697672
57SGK4941.25697672
58PINK11.22173055
59VRK21.19576088
60MET1.16383899
61CDK151.16190811
62MUSK1.16067038
63CAMK2D1.14395207
64CDK71.14325616
65CDK181.13424660
66MAPKAPK51.10726660
67BUB11.08951154
68RIPK11.08395198
69PAK41.06893849
70RPS6KB21.06000310
71CDK11A1.05873090
72AURKA1.02672854
73FGR1.02648556
74TESK20.99873485
75CAMK2A0.99586719
76MAP3K20.98902068
77PAK30.97422164
78TTN0.95080148
79CSNK1G20.95009159
80CAMKK10.94396306
81NEK60.93762986
82CSNK1G30.93452821
83CAMK2G0.93451300
84DAPK10.91259149
85MTOR0.90955016
86DYRK20.89864423
87SRPK10.88357073
88GRK50.88112642
89CDK40.87172908
90CHEK20.86116840
91DAPK20.85266237
92EIF2AK10.84735098
93MAPK110.80936119
94STK110.80904200
95MAP2K40.80781358
96MAP3K120.80539196
97CDK80.79729329
98BRSK10.79254274
99PRKCH0.78221371
100CSNK1A1L0.76460493
101FES0.76337340
102KSR10.75798577
103RET0.73943559
104PRKCE0.73576297
105PDPK10.71190295
106TTK0.70735853
107AKT20.70449851
108MAP2K20.68600811
109ATR0.68035054
110INSRR0.67929463
111RIPK40.65908674
112MAP3K110.65454677
113PRKCG0.65267287
114BRAF0.65251683
115ICK0.63652069
116CAMK1G0.63074925
117ILK0.62333793
118ROCK10.62191605
119TAOK20.62051272
120MARK20.61411263
121IRAK20.59736659
122PLK20.59697822
123FYN0.59407844
124NME10.59130609
125PTK20.59110982
126NEK20.59035496
127MAPK120.58168194
128PBK0.58000497
129PDGFRA0.57724771
130RPS6KA20.57310328
131CSNK1G10.57280174
132PRKD10.57183476
133CAMKK20.55662593
134FER0.53765613
135MAP2K30.52966163
136MAP3K10.52956457
137CLK10.52859962
138DDR20.52326170
139CDK60.52217712
140FGFR40.52009036
141MAP3K80.51927244
142MAP2K10.50882368
143PTK60.50347683
144MAPKAPK30.50258809
145CHEK10.49880595
146DMPK0.49688743
147GRK60.48899516
148CDK20.48861088
149PRKD20.48823584
150PRKCQ0.48519495
151ADRBK10.47347309
152TAOK10.46784071
153PLK10.46524722
154CCNB10.46461018
155DAPK30.46152812
156LATS20.46092416
157CDK10.46048572
158ALK0.43615424
159PRKCZ0.42829988
160CSNK1A10.42728122
161MAPK100.41563676
162AURKB0.41180665
163PRKCI0.41026968
164PIM20.38884850

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.26963671
2DNA replication_Homo sapiens_hsa030303.43148728
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.84415373
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.71604507
5Fructose and mannose metabolism_Homo sapiens_hsa000512.56995315
6Phototransduction_Homo sapiens_hsa047442.56586567
7Base excision repair_Homo sapiens_hsa034102.38426464
8Synaptic vesicle cycle_Homo sapiens_hsa047212.35735568
9GABAergic synapse_Homo sapiens_hsa047272.19968366
10Glutamatergic synapse_Homo sapiens_hsa047242.17118916
11Nicotine addiction_Homo sapiens_hsa050332.15156325
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08161604
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03200955
14Biosynthesis of amino acids_Homo sapiens_hsa012302.01791281
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97911430
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96683220
17Salivary secretion_Homo sapiens_hsa049701.92074921
18Circadian entrainment_Homo sapiens_hsa047131.85391279
19Mismatch repair_Homo sapiens_hsa034301.83020805
20Fatty acid elongation_Homo sapiens_hsa000621.79631251
21Morphine addiction_Homo sapiens_hsa050321.79141520
22Oxidative phosphorylation_Homo sapiens_hsa001901.75694341
23Gastric acid secretion_Homo sapiens_hsa049711.73682509
24Olfactory transduction_Homo sapiens_hsa047401.68449884
25Steroid biosynthesis_Homo sapiens_hsa001001.66795127
26Cardiac muscle contraction_Homo sapiens_hsa042601.65410679
27Vitamin B6 metabolism_Homo sapiens_hsa007501.63904637
28Axon guidance_Homo sapiens_hsa043601.63890702
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.60630203
30Nitrogen metabolism_Homo sapiens_hsa009101.60550990
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60065863
32Dopaminergic synapse_Homo sapiens_hsa047281.58450298
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57307532
34Cell cycle_Homo sapiens_hsa041101.57126200
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56607472
36Serotonergic synapse_Homo sapiens_hsa047261.56303076
37Bladder cancer_Homo sapiens_hsa052191.55533005
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.52936165
39Long-term potentiation_Homo sapiens_hsa047201.52455045
40Ether lipid metabolism_Homo sapiens_hsa005651.51942248
41Long-term depression_Homo sapiens_hsa047301.49813506
42Cholinergic synapse_Homo sapiens_hsa047251.48239258
43Parkinsons disease_Homo sapiens_hsa050121.47221757
44Alzheimers disease_Homo sapiens_hsa050101.46120234
45Pentose phosphate pathway_Homo sapiens_hsa000301.37078510
46Insulin secretion_Homo sapiens_hsa049111.33731233
47Non-small cell lung cancer_Homo sapiens_hsa052231.31538870
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30560279
49Fatty acid biosynthesis_Homo sapiens_hsa000611.30199212
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29583022
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28343163
52Amphetamine addiction_Homo sapiens_hsa050311.27114072
53Cocaine addiction_Homo sapiens_hsa050301.25466883
54Gap junction_Homo sapiens_hsa045401.25402451
55Renin secretion_Homo sapiens_hsa049241.24643088
56Chronic myeloid leukemia_Homo sapiens_hsa052201.24141883
57Sulfur metabolism_Homo sapiens_hsa009201.18980047
58Taste transduction_Homo sapiens_hsa047421.17212052
59GnRH signaling pathway_Homo sapiens_hsa049121.14491262
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.12308206
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09933842
62Carbon metabolism_Homo sapiens_hsa012001.09203024
63Phospholipase D signaling pathway_Homo sapiens_hsa040721.08552713
64Pancreatic secretion_Homo sapiens_hsa049721.05382389
65Mineral absorption_Homo sapiens_hsa049781.05050355
66Fanconi anemia pathway_Homo sapiens_hsa034601.03834524
67Other glycan degradation_Homo sapiens_hsa005111.02740032
68Collecting duct acid secretion_Homo sapiens_hsa049661.02239038
69Oxytocin signaling pathway_Homo sapiens_hsa049211.02156178
70Glycosaminoglycan degradation_Homo sapiens_hsa005311.01894766
71Vibrio cholerae infection_Homo sapiens_hsa051101.01788736
72Endometrial cancer_Homo sapiens_hsa052131.00984237
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99613513
74Nucleotide excision repair_Homo sapiens_hsa034200.98285743
75Pancreatic cancer_Homo sapiens_hsa052120.97768519
76mRNA surveillance pathway_Homo sapiens_hsa030150.97235167
77Pyrimidine metabolism_Homo sapiens_hsa002400.96002335
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95461539
79mTOR signaling pathway_Homo sapiens_hsa041500.95380332
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93155254
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92572699
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92470556
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91375620
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.91362130
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91305858
86Calcium signaling pathway_Homo sapiens_hsa040200.90977197
87Sphingolipid metabolism_Homo sapiens_hsa006000.90018771
88cAMP signaling pathway_Homo sapiens_hsa040240.88884104
89ErbB signaling pathway_Homo sapiens_hsa040120.88223643
90Renal cell carcinoma_Homo sapiens_hsa052110.88125985
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.86786553
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.86590904
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85114613
94Notch signaling pathway_Homo sapiens_hsa043300.84746596
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84668322
96Thyroid cancer_Homo sapiens_hsa052160.84637217
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83790511
98Melanogenesis_Homo sapiens_hsa049160.82727579
99Tight junction_Homo sapiens_hsa045300.82234581
100Dorso-ventral axis formation_Homo sapiens_hsa043200.81446325
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81103083
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79811982
103Endocytosis_Homo sapiens_hsa041440.79599891
104Hippo signaling pathway_Homo sapiens_hsa043900.78929304
105Lysine degradation_Homo sapiens_hsa003100.78524691
106AMPK signaling pathway_Homo sapiens_hsa041520.78019967
107Huntingtons disease_Homo sapiens_hsa050160.77577861
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77544776
109Prion diseases_Homo sapiens_hsa050200.77014499
110Butanoate metabolism_Homo sapiens_hsa006500.76835908
111Choline metabolism in cancer_Homo sapiens_hsa052310.75159314
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75110967
113Spliceosome_Homo sapiens_hsa030400.74517152
114Ras signaling pathway_Homo sapiens_hsa040140.73762898
115Pyruvate metabolism_Homo sapiens_hsa006200.73680584
116Insulin signaling pathway_Homo sapiens_hsa049100.73654603
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73576135
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72605412
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.72326396
120N-Glycan biosynthesis_Homo sapiens_hsa005100.70515804
121Thyroid hormone synthesis_Homo sapiens_hsa049180.70112057
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69342923
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69066045
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68676072
125Dilated cardiomyopathy_Homo sapiens_hsa054140.68330723
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68106281
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68090805
128Homologous recombination_Homo sapiens_hsa034400.67711511
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67101743
130Glioma_Homo sapiens_hsa052140.66697254
131Arginine biosynthesis_Homo sapiens_hsa002200.66350660
132RNA transport_Homo sapiens_hsa030130.66345996
133Estrogen signaling pathway_Homo sapiens_hsa049150.65768684
134Colorectal cancer_Homo sapiens_hsa052100.65005133
135Galactose metabolism_Homo sapiens_hsa000520.64859733
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64659736
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63031071
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62867814
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62720423
140MicroRNAs in cancer_Homo sapiens_hsa052060.62479823
141Arginine and proline metabolism_Homo sapiens_hsa003300.62416921
142Lysosome_Homo sapiens_hsa041420.59828382
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59575040
144Fatty acid metabolism_Homo sapiens_hsa012120.59039187
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58838348
146Glucagon signaling pathway_Homo sapiens_hsa049220.56013710
147Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55507607
148Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55029542
149One carbon pool by folate_Homo sapiens_hsa006700.54730013
150Bile secretion_Homo sapiens_hsa049760.53439840
151Acute myeloid leukemia_Homo sapiens_hsa052210.51824647
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51812407
153VEGF signaling pathway_Homo sapiens_hsa043700.51566211
154Ovarian steroidogenesis_Homo sapiens_hsa049130.51560502
155Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51179869
156Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51023110
157Linoleic acid metabolism_Homo sapiens_hsa005910.48214716
158Type II diabetes mellitus_Homo sapiens_hsa049300.47062717
159Phenylalanine metabolism_Homo sapiens_hsa003600.46959434
160MAPK signaling pathway_Homo sapiens_hsa040100.44579139
161Folate biosynthesis_Homo sapiens_hsa007900.44487904
162Hedgehog signaling pathway_Homo sapiens_hsa043400.41824476
163Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38849084
164Oocyte meiosis_Homo sapiens_hsa041140.38179573
165Alcoholism_Homo sapiens_hsa050340.37780083
166Rap1 signaling pathway_Homo sapiens_hsa040150.36896666
167Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36031450
168Inositol phosphate metabolism_Homo sapiens_hsa005620.35969052

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