PAQR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1organic cation transport (GO:0015695)6.61283217
2desmosome organization (GO:0002934)6.05366170
3sulfation (GO:0051923)5.64750399
4aminoglycoside antibiotic metabolic process (GO:0030647)5.61280646
5excretion (GO:0007588)5.50263334
6polyol transport (GO:0015791)5.46914543
7flavonoid metabolic process (GO:0009812)5.44615296
8phospholipid scrambling (GO:0017121)5.27152444
9response to water (GO:0009415)5.23687493
10renal absorption (GO:0070293)5.16798438
11viral transcription (GO:0019083)5.03044479
12response to mercury ion (GO:0046689)4.83800142
13translational termination (GO:0006415)4.66845833
14nonribosomal peptide biosynthetic process (GO:0019184)4.62506071
15drug transmembrane transport (GO:0006855)4.61591356
16protein K11-linked deubiquitination (GO:0035871)4.43612862
17UDP-N-acetylglucosamine metabolic process (GO:0006047)4.40419244
18glutathione biosynthetic process (GO:0006750)4.40309984
19urate metabolic process (GO:0046415)4.37160298
20ribosomal small subunit assembly (GO:0000028)4.29427001
21acrosome reaction (GO:0007340)4.27747534
22one-carbon compound transport (GO:0019755)4.14176816
23drug transport (GO:0015893)4.08548737
24establishment of skin barrier (GO:0061436)4.07016461
25quaternary ammonium group transport (GO:0015697)4.05738377
26viral life cycle (GO:0019058)3.94721742
27translational elongation (GO:0006414)3.92421894
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90403432
29cellular protein complex disassembly (GO:0043624)3.89593471
30replicative senescence (GO:0090399)3.86841510
31ribosomal small subunit biogenesis (GO:0042274)3.84970407
32regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.84765108
33cotranslational protein targeting to membrane (GO:0006613)3.84233653
34cell wall macromolecule catabolic process (GO:0016998)3.84214621
35cell wall macromolecule metabolic process (GO:0044036)3.84214621
36metanephric nephron tubule development (GO:0072234)3.82983205
37metanephric tubule development (GO:0072170)3.82983205
38protein targeting to ER (GO:0045047)3.82731184
39peripheral nervous system neuron development (GO:0048935)3.82448268
40purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.80880255
413-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.80880255
42vitamin transmembrane transport (GO:0035461)3.76831897
43anterior/posterior axis specification, embryo (GO:0008595)3.72874662
44intestinal absorption (GO:0050892)3.70068550
45regulation of water loss via skin (GO:0033561)3.65126522
46fusion of sperm to egg plasma membrane (GO:0007342)3.62890054
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.61827338
48protein localization to endoplasmic reticulum (GO:0070972)3.57714525
49sperm motility (GO:0030317)3.54633935
50sphingoid metabolic process (GO:0046519)3.54284796
51carnitine metabolic process (GO:0009437)3.53647309
52bundle of His cell to Purkinje myocyte communication (GO:0086069)3.51874883
53metanephric nephron epithelium development (GO:0072243)3.49251417
54cellular glucuronidation (GO:0052695)3.47733800
55nephron epithelium development (GO:0072009)3.45092627
56actin filament depolymerization (GO:0030042)3.41535247
57intestinal epithelial cell development (GO:0060576)3.41108304
58interferon-gamma secretion (GO:0072643)3.39987242
59hemidesmosome assembly (GO:0031581)3.39161822
60regulation of hippo signaling (GO:0035330)3.38243489
61lymphangiogenesis (GO:0001946)3.35566594
62negative regulation of keratinocyte proliferation (GO:0010839)3.32864232
63glomerular visceral epithelial cell development (GO:0072015)3.30217363
64glycoside metabolic process (GO:0016137)3.30194344
65glucuronate metabolic process (GO:0019585)3.29457056
66uronic acid metabolic process (GO:0006063)3.29457056
67nephron tubule development (GO:0072080)3.25711390
68protein complex disassembly (GO:0043241)3.23042752
69keratinocyte proliferation (GO:0043616)3.21778542
70carnitine transport (GO:0015879)3.18757792
71amino-acid betaine transport (GO:0015838)3.18757792
72metanephric epithelium development (GO:0072207)3.18639226
73multicellular organismal water homeostasis (GO:0050891)3.18141977
74negative regulation of protein tyrosine kinase activity (GO:0061099)3.18105916
75dopamine transport (GO:0015872)3.16960273
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09387813
77prenylation (GO:0097354)3.09035817
78protein prenylation (GO:0018342)3.09035817
79peptide biosynthetic process (GO:0043043)3.06591983
80definitive hemopoiesis (GO:0060216)3.06380601
81viral mRNA export from host cell nucleus (GO:0046784)3.05901144
82positive regulation of fatty acid oxidation (GO:0046321)3.02605167
83cell differentiation involved in metanephros development (GO:0072202)2.99612339
84prostate gland growth (GO:0060736)2.98280061
85macromolecular complex disassembly (GO:0032984)2.96267541
86collecting duct development (GO:0072044)2.95523133
87positive regulation of odontogenesis (GO:0042482)2.95294697
88negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.94163790
89glomerular epithelial cell development (GO:0072310)2.92370979
90polyketide metabolic process (GO:0030638)2.91926171
91doxorubicin metabolic process (GO:0044598)2.91926171
92daunorubicin metabolic process (GO:0044597)2.91926171
93positive regulation of respiratory burst (GO:0060267)2.91417356
94smooth muscle tissue development (GO:0048745)2.90410586
95valine metabolic process (GO:0006573)2.89759032
96regulation of cholesterol homeostasis (GO:2000188)2.89506903
97regulation of ruffle assembly (GO:1900027)2.87966837
98renal tubule development (GO:0061326)2.87182720
99glomerular filtration (GO:0003094)2.86767362
100signal transduction involved in regulation of gene expression (GO:0023019)2.85999635
101regulation of apoptotic process involved in morphogenesis (GO:1902337)2.83938222
102protein targeting to membrane (GO:0006612)2.82408113
103response to thyroid hormone (GO:0097066)2.81754975
104positive regulation of fatty acid beta-oxidation (GO:0032000)2.80169638
105magnesium ion transport (GO:0015693)2.77852361
106water homeostasis (GO:0030104)2.77489835
107bile acid and bile salt transport (GO:0015721)2.77413775
108nucleotide-sugar biosynthetic process (GO:0009226)2.77245716
109epithelial cilium movement (GO:0003351)2.76706896
110calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.76123335
111negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.76025371
112endothelium development (GO:0003158)2.73831954
113plasma membrane fusion (GO:0045026)2.72050562
114membrane protein ectodomain proteolysis (GO:0006509)2.70513544
115renal filtration (GO:0097205)2.70299211
116negative regulation of erythrocyte differentiation (GO:0045647)2.70265127
117fat-soluble vitamin catabolic process (GO:0042363)2.70257250
118vitamin catabolic process (GO:0009111)2.70257250
119lysine catabolic process (GO:0006554)2.68087753
120lysine metabolic process (GO:0006553)2.68087753
121glucocorticoid biosynthetic process (GO:0006704)2.67868645
122regulation of somitogenesis (GO:0014807)2.66328886
123L-fucose catabolic process (GO:0042355)2.65283665
124fucose catabolic process (GO:0019317)2.65283665
125L-fucose metabolic process (GO:0042354)2.65283665
126regulation of bile acid biosynthetic process (GO:0070857)2.64610785
127amino sugar catabolic process (GO:0046348)2.63935473
128amino-acid betaine metabolic process (GO:0006577)2.63339619
129behavioral response to pain (GO:0048266)2.63012241
130positive regulation of glomerulus development (GO:0090193)2.62646265
131toxin transport (GO:1901998)2.62432995
132fat-soluble vitamin biosynthetic process (GO:0042362)2.61561803
133dermatan sulfate biosynthetic process (GO:0030208)2.60098130
134diol metabolic process (GO:0034311)2.59746860
135leukotriene biosynthetic process (GO:0019370)2.59137047
136negative regulation of kidney development (GO:0090185)2.58833482
137histamine transport (GO:0051608)2.58345140
138lymphoid progenitor cell differentiation (GO:0002320)2.57863186
139maturation of SSU-rRNA (GO:0030490)2.57613061
140positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57417060
141transepithelial transport (GO:0070633)2.56935556
142sequestering of actin monomers (GO:0042989)2.56385154
143polyol catabolic process (GO:0046174)2.55792479
144membrane budding (GO:0006900)2.55611832
145adenosine metabolic process (GO:0046085)2.55522244
146renal system process (GO:0003014)2.55494933
147inositol phosphate-mediated signaling (GO:0048016)2.55455098
148positive regulation of cellular amine metabolic process (GO:0033240)2.55342755
149histone-serine phosphorylation (GO:0035404)2.54500489
150positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.53846855
151bone remodeling (GO:0046849)2.50164526
152carnitine transmembrane transport (GO:1902603)2.50015466
153cellular response to zinc ion (GO:0071294)2.48022596
154membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.47809768
155negative regulation of systemic arterial blood pressure (GO:0003085)2.42839997
156regulation of DNA damage checkpoint (GO:2000001)2.42778156
157cellular response to cadmium ion (GO:0071276)2.42643486
158eosinophil chemotaxis (GO:0048245)2.41577762
159renal system process involved in regulation of blood volume (GO:0001977)2.39233225
160negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.38017949
161iron ion import (GO:0097286)2.37234647
162angiotensin maturation (GO:0002003)2.34388306
163negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.33928518
164vitamin biosynthetic process (GO:0009110)2.33431744
165positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.32740278
166sulfate transmembrane transport (GO:1902358)2.32103375
167protein K48-linked deubiquitination (GO:0071108)2.31957097
168nucleotide-sugar metabolic process (GO:0009225)2.31460625
169dorsal/ventral axis specification (GO:0009950)2.29343701
170membrane repolarization during action potential (GO:0086011)2.29137895
171regulation of prostaglandin secretion (GO:0032306)2.28959309
172branching involved in prostate gland morphogenesis (GO:0060442)2.28698590
173positive regulation of icosanoid secretion (GO:0032305)2.28648366
174leukotriene metabolic process (GO:0006691)2.27772661
175peristalsis (GO:0030432)2.27214982
176primary alcohol catabolic process (GO:0034310)2.25566719
177cellular response to vitamin D (GO:0071305)2.25512006
178response to xenobiotic stimulus (GO:0009410)2.24319834
179phasic smooth muscle contraction (GO:0014821)2.23841524
180tryptophan metabolic process (GO:0006568)2.23567481
181tight junction assembly (GO:0070830)2.23554888
182proline transport (GO:0015824)2.23436272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.13090692
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.08148512
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.58499423
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.55797148
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.02923042
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.85602824
7GATA1_22025678_ChIP-Seq_K562_Human2.74248945
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65400173
9ZNF263_19887448_ChIP-Seq_K562_Human2.40048306
10TP53_16413492_ChIP-PET_HCT116_Human2.34469565
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31135113
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.30998790
13* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.25133715
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.24366492
15VDR_22108803_ChIP-Seq_LS180_Human2.21112138
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.16990987
17GBX2_23144817_ChIP-Seq_PC3_Human2.10660673
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05972483
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.03011109
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.98827639
21SOX9_24532713_ChIP-Seq_HFSC_Mouse1.96030028
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95833209
23SCL_19346495_ChIP-Seq_HPC-7_Human1.95815973
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91711241
25* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85814417
26P63_26484246_Chip-Seq_KERATINOCYTES_Human1.84739697
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74298596
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.73370699
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67939177
30* SOX2_20726797_ChIP-Seq_SW620_Human1.63983860
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.63939316
32P300_19829295_ChIP-Seq_ESCs_Human1.63560434
33BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.63221627
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57352678
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55633093
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55633093
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55234207
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.52805544
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52398502
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51037572
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50195166
42BRD4_25478319_ChIP-Seq_HGPS_Human1.50051094
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49974712
44FUS_26573619_Chip-Seq_HEK293_Human1.47828355
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47183486
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45616609
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44958270
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44348979
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43565355
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42684688
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41573135
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41573135
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41509570
54RXR_22108803_ChIP-Seq_LS180_Human1.40759014
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.40650970
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40528397
57GATA4_25053715_ChIP-Seq_YYC3_Human1.40443153
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.38430193
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37230811
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.35318329
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35111309
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33768250
63SMAD4_21799915_ChIP-Seq_A2780_Human1.32326461
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.25640196
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25597694
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24413332
67CBP_20019798_ChIP-Seq_JUKART_Human1.24305609
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24305609
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24210317
70AHR_22903824_ChIP-Seq_MCF-7_Human1.23241521
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.21837706
72SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20949576
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20614720
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20610045
75TCF4_22108803_ChIP-Seq_LS180_Human1.19867456
76RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19804347
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.18076786
78EWS_26573619_Chip-Seq_HEK293_Human1.17861787
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.17835137
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17643478
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16962001
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16464157
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15695979
84STAT3_23295773_ChIP-Seq_U87_Human1.15193843
85* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13968752
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13524493
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13030669
88* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11274722
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.11097070
90TAF15_26573619_Chip-Seq_HEK293_Human1.10763424
91CJUN_26792858_Chip-Seq_BT549_Human1.09926160
92ER_23166858_ChIP-Seq_MCF-7_Human1.09151322
93* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07857228
94LXR_22158963_ChIP-Seq_LIVER_Mouse1.06552692
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06275386
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.06069903
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.05954819
98CTCF_27219007_Chip-Seq_Bcells_Human1.05328370
99TP63_23658742_ChIP-Seq_EP156T_Human1.04186295
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02595153
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01133112
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00975212
103AR_25329375_ChIP-Seq_VCAP_Human1.00746045
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00456598
105NANOG_20526341_ChIP-Seq_ESCs_Human0.99513480
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98923665
107RUNX1_27514584_Chip-Seq_MCF-7_Human0.98792059
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98480006
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98042864
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97491009
111SA1_27219007_Chip-Seq_Bcells_Human0.97329951
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.96965525
113ESET_19884257_ChIP-Seq_ESCs_Mouse0.96725327
114AR_20517297_ChIP-Seq_VCAP_Human0.96590600
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95582058
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95411231
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94845923
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94191738
119FLI1_21867929_ChIP-Seq_TH2_Mouse0.94191343
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.93645546
121* TP63_22573176_ChIP-Seq_HFKS_Human0.93284644
122EED_16625203_ChIP-ChIP_MESCs_Mouse0.92202095
123OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92013234
124EGR1_19032775_ChIP-ChIP_M12_Human0.92007495
125SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91298489
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.91230158
127GATA3_21867929_ChIP-Seq_CD8_Mouse0.91113327
128SOX2_22085726_ChIP-Seq_NPCs_Mouse0.90907798
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90839519
130HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90393040
131RAC3_21632823_ChIP-Seq_H3396_Human0.88711663
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88623350
133CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87912124
134PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84310994
135KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83423211
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83162787
137GATA6_25053715_ChIP-Seq_YYC3_Human0.82819398
138CEBPB_22108803_ChIP-Seq_LS180_Human0.81693178
139CTCF_20526341_ChIP-Seq_ESCs_Human0.81627956
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80657459
141RACK7_27058665_Chip-Seq_MCF-7_Human0.80333702
142STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.79923371
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79669167
144GATA2_19941826_ChIP-Seq_K562_Human0.79378514
145ERG_20517297_ChIP-Seq_VCAP_Human0.79220025
146LXR_22292898_ChIP-Seq_THP-1_Human0.78865764
147BCAT_22108803_ChIP-Seq_LS180_Human0.78683091
148SMAD3_21741376_ChIP-Seq_HESCs_Human0.78489990
149CDX2_22108803_ChIP-Seq_LS180_Human0.78401289
150GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78282168
151RUNX_20019798_ChIP-Seq_JUKART_Human0.78001544
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.77607648
153TP53_18474530_ChIP-ChIP_U2OS_Human0.77270182
154PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76781568
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75942655
156BCOR_27268052_Chip-Seq_Bcells_Human0.75772419
157LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.75466951
158P53_21459846_ChIP-Seq_SAOS-2_Human0.74890149
159EP300_21415370_ChIP-Seq_HL-1_Mouse0.74458431
160FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73973989
161VDR_24787735_ChIP-Seq_THP-1_Human0.73386814
162PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72987099
163HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72277511
164EZH2_27294783_Chip-Seq_ESCs_Mouse0.71477220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.48521120
2MP0004043_abnormal_pH_regulation4.13536561
3MP0002796_impaired_skin_barrier4.04295178
4MP0010234_abnormal_vibrissa_follicle3.68854301
5MP0009379_abnormal_foot_pigmentation3.67483301
6MP0003941_abnormal_skin_development3.60349514
7MP0002163_abnormal_gland_morphology3.41594137
8MP0001756_abnormal_urination3.34034273
9MP0001765_abnormal_ion_homeostasis3.18820461
10MP0005410_abnormal_fertilization2.86669126
11MP0003195_calcinosis2.78962793
12MP0009643_abnormal_urine_homeostasis2.76229861
13MP0002009_preneoplasia2.74894466
14MP0002736_abnormal_nociception_after2.57299925
15MP0004264_abnormal_extraembryonic_tissu2.48075505
16MP0005636_abnormal_mineral_homeostasis2.47943941
17MP0002735_abnormal_chemical_nociception2.47788520
18MP0001986_abnormal_taste_sensitivity2.43428431
19MP0003252_abnormal_bile_duct2.37995024
20MP0002136_abnormal_kidney_physiology2.36814397
21MP0005501_abnormal_skin_physiology2.34618646
22MP0001968_abnormal_touch/_nociception2.34424195
23MP0004019_abnormal_vitamin_homeostasis2.29639541
24MP0005365_abnormal_bile_salt2.21126790
25MP0004381_abnormal_hair_follicle2.16067491
26MP0009840_abnormal_foam_cell2.12788552
27MP0005379_endocrine/exocrine_gland_phen2.03690120
28MP0009697_abnormal_copulation2.03295217
29MP0005332_abnormal_amino_acid2.02908136
30MP0000538_abnormal_urinary_bladder1.99652249
31MP0008004_abnormal_stomach_pH1.93098283
32MP0002160_abnormal_reproductive_system1.92168113
33MP0000569_abnormal_digit_pigmentation1.84213673
34MP0008961_abnormal_basal_metabolism1.79099414
35MP0010771_integument_phenotype1.78181363
36MP0000613_abnormal_salivary_gland1.74728072
37MP0005360_urolithiasis1.71814891
38MP0002098_abnormal_vibrissa_morphology1.71432176
39MP0004272_abnormal_basement_membrane1.70832075
40MP0009780_abnormal_chondrocyte_physiolo1.68159779
41MP0001216_abnormal_epidermal_layer1.65612621
42MP0005084_abnormal_gallbladder_morpholo1.64569626
43MP0005409_darkened_coat_color1.62128505
44MP0002396_abnormal_hematopoietic_system1.61464595
45MP0002254_reproductive_system_inflammat1.60366755
46MP0003950_abnormal_plasma_membrane1.58615910
47MP0003315_abnormal_perineum_morphology1.58144277
48MP0005174_abnormal_tail_pigmentation1.56727605
49MP0005377_hearing/vestibular/ear_phenot1.49971120
50MP0003878_abnormal_ear_physiology1.49971120
51MP0002166_altered_tumor_susceptibility1.46374741
52MP0002060_abnormal_skin_morphology1.46269372
53MP0003656_abnormal_erythrocyte_physiolo1.45440121
54MP0000372_irregular_coat_pigmentation1.44153861
55MP0010352_gastrointestinal_tract_polyps1.34538150
56MP0000678_abnormal_parathyroid_gland1.34020961
57MP0005075_abnormal_melanosome_morpholog1.30793565
58MP0001664_abnormal_digestion1.28709203
59MP0001661_extended_life_span1.28013703
60MP0001270_distended_abdomen1.27681880
61MP0001873_stomach_inflammation1.27565301
62MP0003693_abnormal_embryo_hatching1.25527694
63MP0005389_reproductive_system_phenotype1.24862206
64MP0000537_abnormal_urethra_morphology1.24708659
65MP0002006_tumorigenesis1.22791203
66MP0002148_abnormal_hypersensitivity_rea1.21699546
67MP0003638_abnormal_response/metabolism_1.20896395
68MP0000230_abnormal_systemic_arterial1.19665397
69MP0002928_abnormal_bile_duct1.18394044
70MP0010678_abnormal_skin_adnexa1.18080830
71MP0003718_maternal_effect1.17488095
72MP0004858_abnormal_nervous_system1.16896026
73MP0004947_skin_inflammation1.15700044
74MP0000383_abnormal_hair_follicle1.14525592
75MP0001191_abnormal_skin_condition1.12251204
76MP0000516_abnormal_urinary_system1.11980784
77MP0005367_renal/urinary_system_phenotyp1.11980784
78MP0000579_abnormal_nail_morphology1.08314321
79MP0005275_abnormal_skin_tensile1.07671033
80MP0003453_abnormal_keratinocyte_physiol1.07343605
81MP0002138_abnormal_hepatobiliary_system1.06609806
82MP0000377_abnormal_hair_follicle1.06405749
83MP0002095_abnormal_skin_pigmentation1.05340404
84MP0003136_yellow_coat_color1.03672321
85MP0004484_altered_response_of1.02272880
86MP0002733_abnormal_thermal_nociception1.01919571
87MP0005167_abnormal_blood-brain_barrier1.01229703
88MP0003183_abnormal_peptide_metabolism0.98907516
89MP0003937_abnormal_limbs/digits/tail_de0.97878754
90MP0002876_abnormal_thyroid_physiology0.96960451
91MP0003724_increased_susceptibility_to0.95138256
92MP0009053_abnormal_anal_canal0.94730897
93MP0000367_abnormal_coat/_hair0.94281199
94MP0001970_abnormal_pain_threshold0.94215986
95MP0008775_abnormal_heart_ventricle0.94009009
96MP0008057_abnormal_DNA_replication0.93414019
97MP0005164_abnormal_response_to0.92517755
98MP0003866_abnormal_defecation0.91750573
99MP0002896_abnormal_bone_mineralization0.90988446
100MP0000427_abnormal_hair_cycle0.90451639
101MP0005187_abnormal_penis_morphology0.87714504
102MP0005647_abnormal_sex_gland0.87191002
103MP0000163_abnormal_cartilage_morphology0.86700532
104MP0009931_abnormal_skin_appearance0.86197016
105MP0003186_abnormal_redox_activity0.86092281
106MP0005310_abnormal_salivary_gland0.83657267
107MP0008875_abnormal_xenobiotic_pharmacok0.83633335
108MP0000470_abnormal_stomach_morphology0.83405019
109MP0000465_gastrointestinal_hemorrhage0.83311419
110MP0005595_abnormal_vascular_smooth0.83259017
111MP0005165_increased_susceptibility_to0.82690685
112MP0010155_abnormal_intestine_physiology0.82434454
113MP0005083_abnormal_biliary_tract0.81421851
114MP0002135_abnormal_kidney_morphology0.80778247
115MP0001485_abnormal_pinna_reflex0.80229798
116MP0003943_abnormal_hepatobiliary_system0.79871665
117MP0004215_abnormal_myocardial_fiber0.79392247
118MP0010386_abnormal_urinary_bladder0.79128912
119MP0009785_altered_susceptibility_to0.78208350
120MP0001958_emphysema0.77698974
121MP0005220_abnormal_exocrine_pancreas0.77672062
122MP0001881_abnormal_mammary_gland0.77305529
123MP0000467_abnormal_esophagus_morphology0.76386785
124MP0006054_spinal_hemorrhage0.75965401
125MP0000627_abnormal_mammary_gland0.75782262
126MP0005395_other_phenotype0.75017719
127MP0000647_abnormal_sebaceous_gland0.74334993
128MP0001663_abnormal_digestive_system0.74147570
129MP0008872_abnormal_physiological_respon0.72594696
130MP0010329_abnormal_lipoprotein_level0.72101384
131MP0005085_abnormal_gallbladder_physiolo0.71533562
132MP0002971_abnormal_brown_adipose0.71413640
133MP0002089_abnormal_postnatal_growth/wei0.71330553
134MP0000477_abnormal_intestine_morphology0.69324528
135MP0001666_abnormal_nutrient_absorption0.69190506
136MP0002734_abnormal_mechanical_nocicepti0.68916618
137MP0003936_abnormal_reproductive_system0.68266604
138MP0001835_abnormal_antigen_presentation0.67728399
139MP0003959_abnormal_lean_body0.67577266
140MP0005257_abnormal_intraocular_pressure0.67182922
141MP0005464_abnormal_platelet_physiology0.66510325
142MP0000371_diluted_coat_color0.66433799
143MP0000762_abnormal_tongue_morphology0.66429506
144MP0003698_abnormal_male_reproductive0.65991878
145MP0005584_abnormal_enzyme/coenzyme_acti0.65175125
146MP0004147_increased_porphyrin_level0.65059693
147MP0003763_abnormal_thymus_physiology0.64993030
148MP0003191_abnormal_cellular_cholesterol0.63473883
149MP0000013_abnormal_adipose_tissue0.62633413
150MP0000534_abnormal_ureter_morphology0.62290097
151MP0006072_abnormal_retinal_apoptosis0.62054784
152MP0001545_abnormal_hematopoietic_system0.61525235
153MP0005397_hematopoietic_system_phenotyp0.61525235
154MP0005670_abnormal_white_adipose0.61482932
155MP0002102_abnormal_ear_morphology0.60386125
156MP0003806_abnormal_nucleotide_metabolis0.59382655
157MP0002277_abnormal_respiratory_mucosa0.58143707

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)9.18068710
2Hypokalemic alkalosis (HP:0001949)8.16302426
3Hypomagnesemia (HP:0002917)7.67222215
4Hyperactive renin-angiotensin system (HP:0000841)7.18021404
5Abnormality of chloride homeostasis (HP:0011422)7.01234722
6Abnormality of magnesium homeostasis (HP:0004921)6.69560215
7Increased circulating renin level (HP:0000848)6.59483031
8Polyuria (HP:0000103)6.55866342
9Abnormal urine output (HP:0012590)6.06751223
10Abnormality of renal excretion (HP:0011036)5.74953061
11Hyperaldosteronism (HP:0000859)5.58718738
12Renal salt wasting (HP:0000127)5.47486317
13Polydipsia (HP:0001959)5.20880757
14Abnormal drinking behavior (HP:0030082)5.20880757
15Alkalosis (HP:0001948)5.17298879
16Tetany (HP:0001281)4.91109462
17Abnormality of renin-angiotensin system (HP:0000847)4.72048323
18Gout (HP:0001997)4.03085241
19J-shaped sella turcica (HP:0002680)4.00663238
20Hypokalemia (HP:0002900)3.98406593
21Abnormality of liposaccharide metabolism (HP:0010968)3.98082089
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.98082089
23Abnormality of glycolipid metabolism (HP:0010969)3.98082089
24Tongue fasciculations (HP:0001308)3.69142406
25Carpal bone hypoplasia (HP:0001498)3.46138293
26Flat acetabular roof (HP:0003180)3.45603181
27Abnormality of cells of the erythroid lineage (HP:0012130)3.31366036
28Hydroxyprolinuria (HP:0003080)3.27823633
29Abnormality of proline metabolism (HP:0010907)3.27823633
30Thoracolumbar scoliosis (HP:0002944)3.20782416
31Vertebral arch anomaly (HP:0008438)3.20074928
32Abnormality of potassium homeostasis (HP:0011042)3.07310476
33Congenital sensorineural hearing impairment (HP:0008527)3.06767246
34Adrenal overactivity (HP:0002717)3.05086448
35Reticulocytopenia (HP:0001896)3.00240473
36Aortic regurgitation (HP:0001659)2.96509430
37Diastasis recti (HP:0001540)2.94103064
38Hyperuricemia (HP:0002149)2.89755491
39Increased purine levels (HP:0004368)2.89755491
40Muscle fibrillation (HP:0010546)2.89034682
41Popliteal pterygium (HP:0009756)2.85558920
42Lip pit (HP:0100267)2.81288127
43Abnormality of sodium homeostasis (HP:0010931)2.79775363
44Dehydration (HP:0001944)2.78765067
45Hypoplasia of the uterus (HP:0000013)2.62962710
46Hypotrichosis (HP:0001006)2.61331071
47Hyponatremia (HP:0002902)2.60894064
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.59491373
49Conjugated hyperbilirubinemia (HP:0002908)2.58762554
50Hypercalciuria (HP:0002150)2.57974878
51Deformed sella turcica (HP:0002681)2.55725796
52Abnormal number of erythroid precursors (HP:0012131)2.54443049
53Protuberant abdomen (HP:0001538)2.46379092
54Abnormality of the nasal septum (HP:0000419)2.42696143
55Abnormality of the odontoid process (HP:0003310)2.34709214
56Tubular atrophy (HP:0000092)2.31315114
57Abnormality of purine metabolism (HP:0004352)2.28849416
58Abnormality of fatty-acid metabolism (HP:0004359)2.23518828
59Mutism (HP:0002300)2.23405133
60Decreased circulating renin level (HP:0003351)2.19533437
61Absent/shortened dynein arms (HP:0200106)2.18874064
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.18874064
63Abnormal hemoglobin (HP:0011902)2.18261023
64Mucopolysacchariduria (HP:0008155)2.18011229
65Urinary glycosaminoglycan excretion (HP:0003541)2.18011229
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.17266437
67Generalized aminoaciduria (HP:0002909)2.16462052
68Renal tubular acidosis (HP:0001947)2.16411164
69Hoarse voice (HP:0001609)2.15302713
70Broad ribs (HP:0000885)2.15259449
71Woolly hair (HP:0002224)2.15238632
72Anomalous pulmonary venous return (HP:0010772)2.12766295
73Macrocytic anemia (HP:0001972)2.11769225
74Abnormality of the axillary hair (HP:0100134)2.11567789
75Abnormality of secondary sexual hair (HP:0009888)2.11567789
76Short hallux (HP:0010109)2.11266439
77Short 1st metacarpal (HP:0010034)2.10478241
78Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.10478241
79Fair hair (HP:0002286)2.10454078
80Slow saccadic eye movements (HP:0000514)2.09751455
81Proximal tubulopathy (HP:0000114)2.08929611
82Abnormality of the sella turcica (HP:0002679)2.08832579
83Abnormality of the 1st metacarpal (HP:0010009)2.08644737
84Onycholysis (HP:0001806)2.08374831
85Potter facies (HP:0002009)2.06277944
86Facial shape deformation (HP:0011334)2.06277944
87Chronic bronchitis (HP:0004469)2.05598467
88Oral leukoplakia (HP:0002745)2.05269066
89Conjunctival hamartoma (HP:0100780)2.05074176
90Furrowed tongue (HP:0000221)2.04665296
91Erythema (HP:0010783)2.04642423
92Vacuolated lymphocytes (HP:0001922)2.04216999
93Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.03845185
94Abnormality of the pulmonary veins (HP:0011718)2.02863548
95Congenital, generalized hypertrichosis (HP:0004540)2.02105223
96Abdominal distention (HP:0003270)2.01786045
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01733482
98Abnormality of the proximal phalanges of the hand (HP:0009834)2.01076344
99Right ventricular cardiomyopathy (HP:0011663)2.00754071
100Abnormality of the lumbar spine (HP:0100712)2.00743399
101Abnormality of polysaccharide metabolism (HP:0011012)2.00499903
102Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00499903
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00499903
104Vascular calcification (HP:0004934)2.00197117
105Wide intermamillary distance (HP:0006610)1.99527129
106Thickened calvaria (HP:0002684)1.98906886
107Pancreatic cysts (HP:0001737)1.97688631
108Aplasia/Hypoplasia of the hallux (HP:0008362)1.97509859
109Nephrocalcinosis (HP:0000121)1.95764547
110Large eyes (HP:0001090)1.94910650
111Impaired platelet aggregation (HP:0003540)1.94475102
112Abnormal platelet function (HP:0011869)1.94475102
113Abnormality of the humerus (HP:0003063)1.93615562
114Focal segmental glomerulosclerosis (HP:0000097)1.93204215
115Congenital ichthyosiform erythroderma (HP:0007431)1.92783970
116Hyperglycinuria (HP:0003108)1.91673643
117IgM deficiency (HP:0002850)1.90966357
118Cardiovascular calcification (HP:0011915)1.88462052
119Thoracic kyphosis (HP:0002942)1.87864068
120Short humerus (HP:0005792)1.86943687
121Malnutrition (HP:0004395)1.86530497
122Clumsiness (HP:0002312)1.86484190
123Nasal polyposis (HP:0100582)1.86397553
124Cavernous hemangioma (HP:0001048)1.84835804
125Neonatal onset (HP:0003623)1.84311188
126Fragile nails (HP:0001808)1.83795667
127Chorioretinal atrophy (HP:0000533)1.82455317
128Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82284572
129Hamartoma of the eye (HP:0010568)1.82200285
130Increased IgE level (HP:0003212)1.81600475
131Chronic diarrhea (HP:0002028)1.81482785
132Abnormality of the upper arm (HP:0001454)1.81331747
133Milia (HP:0001056)1.81082152
134Pigmentary retinal degeneration (HP:0001146)1.80454019
135Abolished electroretinogram (ERG) (HP:0000550)1.80416990
136True hermaphroditism (HP:0010459)1.80198500
137Flared iliac wings (HP:0002869)1.79735418
138Hypotension (HP:0002615)1.77537864
139Abnormal pancreas size (HP:0012094)1.76665513
140Genetic anticipation (HP:0003743)1.75776523
141Abnormality of the vitamin B12 metabolism (HP:0004341)1.74325259
142Stenosis of the external auditory canal (HP:0000402)1.74163515
143Pathologic fracture (HP:0002756)1.73275903
144Abnormality of the nasal mucosa (HP:0000433)1.72999221
145Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72916324
146Generalized muscle weakness (HP:0003324)1.72801323
147Myositis (HP:0100614)1.72519799
148Glycosuria (HP:0003076)1.68935894
149Abnormality of urine glucose concentration (HP:0011016)1.68935894
150Parakeratosis (HP:0001036)1.67630157
151Segmental peripheral demyelination/remyelination (HP:0003481)1.66548534
152Myotonia (HP:0002486)1.65944343
153Tubulointerstitial fibrosis (HP:0005576)1.64472422
154Distal lower limb muscle weakness (HP:0009053)1.62308586
155Hypothermia (HP:0002045)1.61606845
156Abnormal respiratory motile cilium physiology (HP:0012261)1.61201473
157Plantar hyperkeratosis (HP:0007556)1.60715978
158Abnormality of nucleobase metabolism (HP:0010932)1.59735247
159Confusion (HP:0001289)1.57754110
160Vomiting (HP:0002013)1.56693916
161Bronchitis (HP:0012387)1.54456423
162Abnormality of renal resorption (HP:0011038)1.53452018
163Pallor (HP:0000980)1.52898939
164Corneal erosion (HP:0200020)1.52095736
165Ectropion (HP:0000656)1.52005903
166Sparse eyelashes (HP:0000653)1.51119318
167Abnormal respiratory epithelium morphology (HP:0012253)1.50534746
168Abnormal respiratory motile cilium morphology (HP:0005938)1.50534746
169Delayed CNS myelination (HP:0002188)1.50144069
170Glomerulosclerosis (HP:0000096)1.49861219
171Down-sloping shoulders (HP:0200021)1.49458019
172Myokymia (HP:0002411)1.45172696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.39646845
2OXSR14.59657460
3WNK44.53347608
4ACVR1B3.80502703
5EPHA23.16172871
6BLK3.12509015
7PDK23.01424799
8MAPKAPK32.90092411
9PIM22.72988240
10ERBB42.55433703
11MST42.50620847
12GRK52.31215029
13MET2.30632850
14NME22.16856012
15BCKDK2.14137241
16PDK42.12939285
17PDK32.12939285
18STK391.97412828
19FLT31.97404122
20TLK11.97274816
21MST1R1.94101801
22KIT1.84608775
23MAP3K21.69180844
24TESK11.68829902
25RIPK41.65068900
26AKT31.62609595
27LATS11.59375715
28LRRK21.56643889
29MAP3K121.54735209
30MAPKAPK51.52521857
31TIE11.50437471
32ZAK1.49063272
33MAP2K21.46869418
34PBK1.44672517
35GRK71.43938645
36IRAK31.38502782
37MATK1.34742583
38MAP3K31.34006552
39MYLK1.31161255
40CAMK1D1.21363950
41BMPR1B1.21088081
42MAP2K61.20010400
43ABL21.18360020
44TGFBR11.16494913
45MAPK151.15570327
46EEF2K1.14658092
47RPS6KB21.13955226
48ADRBK21.12816806
49MELK1.10067208
50TEC1.06323438
51NEK91.05798397
52TBK11.05303331
53TRPM71.04560632
54INSRR1.00782079
55STK31.00061805
56TGFBR20.99320603
57TAF10.96213164
58DDR20.94031429
59STK100.93860819
60RIPK10.89965336
61MAP2K30.88963154
62TAOK20.87349431
63NLK0.87201038
64ARAF0.86918157
65STK380.83205876
66SGK20.81248692
67PRKG20.77870275
68SGK4940.77618567
69SGK2230.77618567
70TAOK10.77306694
71CSF1R0.75572716
72CAMK1G0.75468742
73IRAK20.73011171
74FER0.69962800
75TAOK30.68804760
76PRKCI0.68635978
77IRAK10.67985883
78IKBKE0.67588817
79LMTK20.66858592
80TYK20.65848941
81STK240.65839334
82BTK0.64050329
83MAPK110.62074735
84MARK30.60199366
85LIMK10.59801998
86SCYL20.59713191
87GRK10.59575579
88MAP3K10.58982626
89MOS0.57661800
90PTK2B0.56747912
91EIF2AK30.56233152
92DYRK1B0.56076103
93CAMK40.52318330
94MAP4K10.52301868
95ITK0.50136612
96CDK80.49936426
97TSSK60.47907394
98MAP2K10.47680538
99BRSK20.46376608
100MAP3K140.46090988
101TNK20.45748907
102DYRK30.45610452
103TRIM280.45172357
104FRK0.44671202
105CDK190.44655902
106MAPK120.44296099
107PDK10.43499953
108STK40.42434662
109GRK60.42373446
110PRKD30.41451795
111PTK20.41024777
112PLK20.40655162
113IRAK40.40256677
114MAPK40.38699912
115RPS6KA20.37890619
116LCK0.36950363
117PIK3CG0.36188427
118ZAP700.35643686
119SGK30.35170591
120NEK10.35119332
121ADRBK10.34433359
122YES10.34408085
123IKBKB0.32630990
124PRKAA10.31384059
125CAMK2D0.31282978
126CAMKK20.31213694
127PIM10.30585517
128PRKCD0.30454977
129CDK90.29919947
130PRKCE0.29473634
131ERBB20.29364912
132PRKAA20.28417716
133TNIK0.28258773
134EPHA30.27470619
135PINK10.27391412
136VRK10.26903113
137FGFR40.25928373
138FGFR10.25746087
139MKNK20.25716760
140WNK10.25591493
141STK38L0.25326436
142SIK10.24655971
143HIPK20.23304045
144NUAK10.23232588
145PLK10.23213541
146EPHB20.23056205
147MUSK0.22905163
148CAMK2B0.22766963
149PRKCA0.22549178
150PDPK10.22342794
151PDGFRB0.21819297
152ERBB30.21618303
153IGF1R0.20980287
154CDK120.20960095
155EIF2AK20.19319087
156PIK3CA0.17752608
157PLK30.17742916

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.40638662
2Ribosome_Homo sapiens_hsa030104.20985229
3Cyanoamino acid metabolism_Homo sapiens_hsa004604.14027513
4Vitamin digestion and absorption_Homo sapiens_hsa049773.24117360
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.82733199
6Mineral absorption_Homo sapiens_hsa049782.52398082
7Sulfur metabolism_Homo sapiens_hsa009202.44267127
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.42540137
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40051590
10Oxidative phosphorylation_Homo sapiens_hsa001902.36526817
11Collecting duct acid secretion_Homo sapiens_hsa049662.23593180
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17176552
13Fat digestion and absorption_Homo sapiens_hsa049752.06085597
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95379658
15Selenocompound metabolism_Homo sapiens_hsa004501.90647579
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.87530060
17Parkinsons disease_Homo sapiens_hsa050121.86713618
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77207600
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75316233
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74216736
21Bile secretion_Homo sapiens_hsa049761.71924378
22Protein digestion and absorption_Homo sapiens_hsa049741.70450271
23Sphingolipid metabolism_Homo sapiens_hsa006001.61816456
24Arachidonic acid metabolism_Homo sapiens_hsa005901.60449431
25Glutathione metabolism_Homo sapiens_hsa004801.59811067
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.58975915
27Caffeine metabolism_Homo sapiens_hsa002321.58772326
28Propanoate metabolism_Homo sapiens_hsa006401.58323600
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57131610
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54397467
31Nitrogen metabolism_Homo sapiens_hsa009101.52837911
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.52806102
33Galactose metabolism_Homo sapiens_hsa000521.49839337
34Systemic lupus erythematosus_Homo sapiens_hsa053221.46383461
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43635944
36Peroxisome_Homo sapiens_hsa041461.43310058
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41857915
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31866349
39Fructose and mannose metabolism_Homo sapiens_hsa000511.27095907
40Linoleic acid metabolism_Homo sapiens_hsa005911.21631810
41Dorso-ventral axis formation_Homo sapiens_hsa043201.21144309
42Vitamin B6 metabolism_Homo sapiens_hsa007501.20850992
43Fatty acid biosynthesis_Homo sapiens_hsa000611.20530718
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20512720
45Gastric acid secretion_Homo sapiens_hsa049711.19755963
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18821826
47Alzheimers disease_Homo sapiens_hsa050101.18500921
48Fatty acid elongation_Homo sapiens_hsa000621.15968714
49Fatty acid degradation_Homo sapiens_hsa000711.15943748
50Pancreatic secretion_Homo sapiens_hsa049721.15792432
51TGF-beta signaling pathway_Homo sapiens_hsa043501.13556427
52Huntingtons disease_Homo sapiens_hsa050161.13026738
53Cardiac muscle contraction_Homo sapiens_hsa042601.09860555
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07351393
55Chemical carcinogenesis_Homo sapiens_hsa052041.04134595
56beta-Alanine metabolism_Homo sapiens_hsa004101.00733181
57Hematopoietic cell lineage_Homo sapiens_hsa046400.98606351
58Pyruvate metabolism_Homo sapiens_hsa006200.98004211
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95601385
60Histidine metabolism_Homo sapiens_hsa003400.91537570
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91505623
62Other glycan degradation_Homo sapiens_hsa005110.87292480
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.84470581
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82426811
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81755643
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77255433
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76904916
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76624942
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75097825
70Renin-angiotensin system_Homo sapiens_hsa046140.73598708
71Melanoma_Homo sapiens_hsa052180.72161723
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71486857
73Retinol metabolism_Homo sapiens_hsa008300.70844602
74Circadian rhythm_Homo sapiens_hsa047100.70812557
75Lysosome_Homo sapiens_hsa041420.70536605
76Tryptophan metabolism_Homo sapiens_hsa003800.70508773
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.70201102
78Phenylalanine metabolism_Homo sapiens_hsa003600.69949775
79Butanoate metabolism_Homo sapiens_hsa006500.69831418
80Glycerolipid metabolism_Homo sapiens_hsa005610.69608280
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68918300
82Thyroid cancer_Homo sapiens_hsa052160.67710433
83Folate biosynthesis_Homo sapiens_hsa007900.67025282
84Thyroid hormone synthesis_Homo sapiens_hsa049180.64604416
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64417199
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.63288660
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62956646
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62648073
89ECM-receptor interaction_Homo sapiens_hsa045120.62111481
90Metabolic pathways_Homo sapiens_hsa011000.61520016
91Alcoholism_Homo sapiens_hsa050340.60753114
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59345492
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58626394
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56543539
95Arginine biosynthesis_Homo sapiens_hsa002200.54023946
96Tight junction_Homo sapiens_hsa045300.53211000
97Hepatitis C_Homo sapiens_hsa051600.52688665
98Renin secretion_Homo sapiens_hsa049240.51047879
99Ether lipid metabolism_Homo sapiens_hsa005650.50902533
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50438049
101Hippo signaling pathway_Homo sapiens_hsa043900.49874834
102PPAR signaling pathway_Homo sapiens_hsa033200.49859750
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.49329458
104ABC transporters_Homo sapiens_hsa020100.49263051
105Pentose phosphate pathway_Homo sapiens_hsa000300.48722930
106Rheumatoid arthritis_Homo sapiens_hsa053230.48694473
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.48536055
108Inositol phosphate metabolism_Homo sapiens_hsa005620.44269141
109Proteoglycans in cancer_Homo sapiens_hsa052050.44238311
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44133742
111Insulin resistance_Homo sapiens_hsa049310.41797862
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41316610
113MicroRNAs in cancer_Homo sapiens_hsa052060.39737209
114Salmonella infection_Homo sapiens_hsa051320.39336892
115Carbon metabolism_Homo sapiens_hsa012000.39243313
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39140276
117Fatty acid metabolism_Homo sapiens_hsa012120.37769482
118TNF signaling pathway_Homo sapiens_hsa046680.37515547
119Bladder cancer_Homo sapiens_hsa052190.30628298
120Salivary secretion_Homo sapiens_hsa049700.29586080
121Sulfur relay system_Homo sapiens_hsa041220.29445278
122Taste transduction_Homo sapiens_hsa047420.28457076
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.27999165
124Hedgehog signaling pathway_Homo sapiens_hsa043400.27712999
125Pyrimidine metabolism_Homo sapiens_hsa002400.27676405
126Focal adhesion_Homo sapiens_hsa045100.27646637
127Regulation of autophagy_Homo sapiens_hsa041400.27539507
128Fanconi anemia pathway_Homo sapiens_hsa034600.27277947
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26690014
130p53 signaling pathway_Homo sapiens_hsa041150.26523483
131Ovarian steroidogenesis_Homo sapiens_hsa049130.25991407
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25222571
133Calcium signaling pathway_Homo sapiens_hsa040200.24288121
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.24110582
135Small cell lung cancer_Homo sapiens_hsa052220.23172910
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22644538
137Basal cell carcinoma_Homo sapiens_hsa052170.22516613
138Adherens junction_Homo sapiens_hsa045200.22359824
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21804028
140Platelet activation_Homo sapiens_hsa046110.21731937
141Pertussis_Homo sapiens_hsa051330.20916695
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20551424
143Starch and sucrose metabolism_Homo sapiens_hsa005000.20308312
144African trypanosomiasis_Homo sapiens_hsa051430.19093880
145Influenza A_Homo sapiens_hsa051640.18563507
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.17936949

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