PAQR6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)7.88879198
2glutamate secretion (GO:0014047)7.16218802
3synaptic vesicle exocytosis (GO:0016079)6.76909881
4regulation of synaptic vesicle exocytosis (GO:2000300)6.17716089
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.74829829
6neurotransmitter secretion (GO:0007269)5.42195883
7regulation of synaptic vesicle transport (GO:1902803)5.29870984
8L-amino acid import (GO:0043092)5.09994946
9regulation of neuronal synaptic plasticity (GO:0048168)5.01545374
10positive regulation of synapse maturation (GO:0090129)4.93525602
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76590765
12axon ensheathment in central nervous system (GO:0032291)4.72322880
13central nervous system myelination (GO:0022010)4.72322880
14amino acid import (GO:0043090)4.71925116
15vocalization behavior (GO:0071625)4.68915971
16positive regulation of cellular amide metabolic process (GO:0034250)4.63230582
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49200816
18neuronal ion channel clustering (GO:0045161)4.45351183
19neurotransmitter transport (GO:0006836)4.38181635
20exploration behavior (GO:0035640)4.28670339
21response to auditory stimulus (GO:0010996)4.12403805
22positive regulation of dendritic spine development (GO:0060999)4.11916846
23regulation of synapse structural plasticity (GO:0051823)4.11525919
24regulation of glutamate receptor signaling pathway (GO:1900449)4.10636802
25glycine transport (GO:0015816)4.08912351
26cellular potassium ion homeostasis (GO:0030007)4.07531650
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02370528
28regulation of neurotransmitter levels (GO:0001505)4.02067043
29neuromuscular process controlling balance (GO:0050885)3.98570398
30regulation of ARF protein signal transduction (GO:0032012)3.94917225
31regulation of synaptic plasticity (GO:0048167)3.90780685
32positive regulation of membrane potential (GO:0045838)3.90093062
33regulation of synapse maturation (GO:0090128)3.87972603
34regulation of neurotransmitter secretion (GO:0046928)3.82293582
35daunorubicin metabolic process (GO:0044597)3.82293369
36polyketide metabolic process (GO:0030638)3.82293369
37doxorubicin metabolic process (GO:0044598)3.82293369
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.80945776
39atrial cardiac muscle cell action potential (GO:0086014)3.75681222
40neurotransmitter uptake (GO:0001504)3.75452565
41regulation of beta-amyloid formation (GO:1902003)3.74546912
42negative regulation of astrocyte differentiation (GO:0048712)3.74295930
43regulation of voltage-gated calcium channel activity (GO:1901385)3.72824121
44synaptic vesicle endocytosis (GO:0048488)3.69712503
45gamma-aminobutyric acid transport (GO:0015812)3.69587870
46dendritic spine morphogenesis (GO:0060997)3.68437762
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.67206045
48ovulation cycle (GO:0042698)3.66980264
49C4-dicarboxylate transport (GO:0015740)3.61485133
50cerebellar Purkinje cell differentiation (GO:0021702)3.60380020
51auditory behavior (GO:0031223)3.60314905
52neuron-neuron synaptic transmission (GO:0007270)3.58815482
53regulation of neurotransmitter transport (GO:0051588)3.53602858
54neurotransmitter-gated ion channel clustering (GO:0072578)3.53005247
55negative regulation of protein localization to cell surface (GO:2000009)3.51913673
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.49513745
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.49366670
58negative regulation of dendrite morphogenesis (GO:0050774)3.47222157
59regulation of postsynaptic membrane potential (GO:0060078)3.46997483
60regulation of phospholipid biosynthetic process (GO:0071071)3.45016315
61layer formation in cerebral cortex (GO:0021819)3.44899632
62long-term memory (GO:0007616)3.39752845
63regulation of dendritic spine morphogenesis (GO:0061001)3.37869821
64regulation of dendritic spine development (GO:0060998)3.35360893
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33580993
66long-term synaptic potentiation (GO:0060291)3.33275096
67regulation of vesicle fusion (GO:0031338)3.31509627
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.30800091
69positive regulation of neurotransmitter transport (GO:0051590)3.30078551
70sodium ion export (GO:0071436)3.26669420
71regulation of timing of cell differentiation (GO:0048505)3.26657865
72proline transport (GO:0015824)3.26625310
73positive regulation of neurotransmitter secretion (GO:0001956)3.24121468
74cerebellar granule cell differentiation (GO:0021707)3.23389156
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18671726
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18378750
77cytoskeletal anchoring at plasma membrane (GO:0007016)3.18279232
78alanine transport (GO:0032328)3.16727678
79regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.16366182
80positive regulation of dendritic spine morphogenesis (GO:0061003)3.16293572
81regulation of synaptic transmission (GO:0050804)3.16089445
82neuron cell-cell adhesion (GO:0007158)3.11080606
83response to pheromone (GO:0019236)3.10904664
84membrane depolarization (GO:0051899)3.09204877
85neuromuscular process controlling posture (GO:0050884)3.07609542
86positive regulation of potassium ion transmembrane transport (GO:1901381)3.05667910
87regulation of amyloid precursor protein catabolic process (GO:1902991)3.04989551
88cell differentiation in hindbrain (GO:0021533)3.04064168
89dendritic spine organization (GO:0097061)3.03925472
90potassium ion homeostasis (GO:0055075)3.03593808
91ionotropic glutamate receptor signaling pathway (GO:0035235)3.03424909
92cellular response to cholesterol (GO:0071397)3.03155770
93myelin maintenance (GO:0043217)3.02877327
94positive regulation of dendrite development (GO:1900006)3.02806565
95glutamate receptor signaling pathway (GO:0007215)3.02480678
96regulation of female receptivity (GO:0045924)3.02430439
97cell communication by electrical coupling (GO:0010644)3.02230793
98establishment of synaptic vesicle localization (GO:0097480)3.01674593
99synaptic vesicle transport (GO:0048489)3.01674593
100membrane depolarization during action potential (GO:0086010)3.01134297
101regulation of response to osmotic stress (GO:0047484)2.97354061
102regulation of activation of Janus kinase activity (GO:0010533)2.96594858
103mechanosensory behavior (GO:0007638)2.96562002
104cerebellar Purkinje cell layer development (GO:0021680)2.95767300
105cellular sodium ion homeostasis (GO:0006883)2.95507039
106synaptic transmission (GO:0007268)2.95201791
107neuromuscular process (GO:0050905)2.93278636
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91391109
109transmission of nerve impulse (GO:0019226)2.89769878
110oligodendrocyte differentiation (GO:0048709)2.89449677
111synaptic transmission, glutamatergic (GO:0035249)2.86342588
112neuronal action potential propagation (GO:0019227)2.82691645
113protein heterotetramerization (GO:0051290)2.80854429
114potassium ion import (GO:0010107)2.80240498
115peripheral nervous system axon ensheathment (GO:0032292)2.74939805
116myelination in peripheral nervous system (GO:0022011)2.74939805
117presynaptic membrane organization (GO:0097090)2.73561169
118acidic amino acid transport (GO:0015800)2.73440131
119low-density lipoprotein particle remodeling (GO:0034374)2.72444308
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71700231
121chondroitin sulfate catabolic process (GO:0030207)2.69646303
122regulation of astrocyte differentiation (GO:0048710)2.69322002
123postsynaptic membrane organization (GO:0001941)2.68526090
124presynaptic membrane assembly (GO:0097105)2.68401621
125regulation of development, heterochronic (GO:0040034)2.66645957
126cellular anion homeostasis (GO:0030002)2.64611691
127detection of temperature stimulus (GO:0016048)2.59599430
128dermatan sulfate metabolic process (GO:0030205)2.59312759
129locomotory exploration behavior (GO:0035641)2.57289403
130regulation of respiratory system process (GO:0044065)2.56981703
131negative regulation of hormone metabolic process (GO:0032351)2.53848918
132negative regulation of hormone biosynthetic process (GO:0032353)2.53848918
133one-carbon compound transport (GO:0019755)2.53693030
134regulation of membrane repolarization (GO:0060306)2.50688432
135dermatan sulfate biosynthetic process (GO:0030208)2.50512719
136adenine nucleotide transport (GO:0051503)2.49224258
137cerebral cortex radially oriented cell migration (GO:0021799)2.48058548
138synaptic vesicle maturation (GO:0016188)2.48055838
139positive regulation of potassium ion transport (GO:0043268)2.47758866
140righting reflex (GO:0060013)2.44464231
141reflex (GO:0060004)2.43366081
142positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.43026676
143regulation of short-term neuronal synaptic plasticity (GO:0048172)2.42952451
144cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.41565982
145adult walking behavior (GO:0007628)2.41123025
146purine ribonucleotide transport (GO:0015868)2.40824538
147myelination (GO:0042552)2.40368970
148negative regulation of smoothened signaling pathway (GO:0045879)2.40253651
149cellular response to sterol (GO:0036315)2.38943062
150drinking behavior (GO:0042756)2.38535103
151regulation of synaptic transmission, glutamatergic (GO:0051966)2.38283233
152negative regulation of neurotransmitter transport (GO:0051589)2.38228873
153regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.34607693
154L-glutamate transport (GO:0015813)2.34518392
155protein localization to synapse (GO:0035418)2.34375451
156import into cell (GO:0098657)2.33903834
157regulation of respiratory gaseous exchange (GO:0043576)2.33632169
158regulation of cellular amide metabolic process (GO:0034248)2.33257825
159membrane repolarization (GO:0086009)2.32647307
160response to dietary excess (GO:0002021)2.31753040
161negative regulation of glial cell differentiation (GO:0045686)2.29944913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.60363611
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.58326586
3GBX2_23144817_ChIP-Seq_PC3_Human3.34131259
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.26680513
5* RARB_27405468_Chip-Seq_BRAIN_Mouse3.22502219
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.95221813
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.79951950
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.59585209
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55575153
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54753233
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49217615
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47884457
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.44540662
14AR_21572438_ChIP-Seq_LNCaP_Human2.37755473
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23536830
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23536830
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16797853
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11209434
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11003568
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.10677235
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09830238
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08779285
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.05018481
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.01507913
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01067014
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.00618479
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.96646632
28KDM2B_26808549_Chip-Seq_K562_Human1.95047616
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93322416
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.91060936
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.90109776
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89867681
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.87965874
34RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.86651323
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81494893
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81166447
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71513427
38EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67220242
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.66745916
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66583342
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64813140
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.63030227
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59097505
44REST_21632747_ChIP-Seq_MESCs_Mouse1.55153430
45RNF2_27304074_Chip-Seq_NSC_Mouse1.54842299
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.54639581
47SMAD4_21799915_ChIP-Seq_A2780_Human1.51966922
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51166079
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50416768
50* LXR_22292898_ChIP-Seq_THP-1_Human1.48824885
51DROSHA_22980978_ChIP-Seq_HELA_Human1.47359396
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47067408
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46596784
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46304657
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46058628
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45740726
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44396918
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41693373
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41310544
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41073704
61P300_19829295_ChIP-Seq_ESCs_Human1.41010879
62CTCF_27219007_Chip-Seq_Bcells_Human1.40341278
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.39571848
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39331527
65IGF1R_20145208_ChIP-Seq_DFB_Human1.38607270
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36741001
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35773216
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35454483
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.35412052
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.35244573
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.35110590
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33860812
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33264235
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33059960
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28844431
76STAT3_23295773_ChIP-Seq_U87_Human1.28678372
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.28654736
78AR_25329375_ChIP-Seq_VCAP_Human1.27575479
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.27560841
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27522296
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27035880
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26870459
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25425536
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23840358
85NMYC_18555785_Chip-Seq_ESCs_Mouse1.23502832
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.21839255
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16995630
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16769866
89P300_18555785_Chip-Seq_ESCs_Mouse1.16709798
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16694603
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.15535576
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15452409
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15269814
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14740259
95OCT4_19829295_ChIP-Seq_ESCs_Human1.14702897
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14396583
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.13720800
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.13164906
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.12793454
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12763665
101RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12686517
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12578813
103P53_22387025_ChIP-Seq_ESCs_Mouse1.12195239
104RUNX2_22187159_ChIP-Seq_PCA_Human1.11999905
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11383233
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11359908
107* SMC4_20622854_ChIP-Seq_HELA_Human1.11174592
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11003388
109ZFX_18555785_Chip-Seq_ESCs_Mouse1.10877103
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.10721006
111ESRRB_18555785_Chip-Seq_ESCs_Mouse1.09650768
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08889539
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.08662526
114CTCF_18555785_Chip-Seq_ESCs_Mouse1.07871578
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.06230690
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.06218414
117KDM2B_26808549_Chip-Seq_DND41_Human1.06167284
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05830089
119PU1_27457419_Chip-Seq_LIVER_Mouse1.05713430
120SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05442151
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05062315
122AR_19668381_ChIP-Seq_PC3_Human1.04928510
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.04847463
124REST_18959480_ChIP-ChIP_MESCs_Mouse1.03846819
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03726147
126EZH2_27294783_Chip-Seq_NPCs_Mouse1.03693423
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02598738
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02491213
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02383372
130TP53_18474530_ChIP-ChIP_U2OS_Human1.01527532
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01286589
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.99418702
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98348396
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97914455
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97642485
136EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96710166
137KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96468481
138KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96468481
139KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96468481
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95753227
141P68_20966046_ChIP-Seq_HELA_Human0.95596815
142* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95556218
143DPY_21335234_ChIP-Seq_ESCs_Mouse0.95458568
144TCF4_23295773_ChIP-Seq_U87_Human0.95104782
145ER_23166858_ChIP-Seq_MCF-7_Human0.94422070
146CREB1_26743006_Chip-Seq_LNCaP_Human0.91449373
147CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91087579
148KLF4_19829295_ChIP-Seq_ESCs_Human0.90917539
149TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88774867
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88198830
151KDM2B_26808549_Chip-Seq_JURKAT_Human0.87996505
152EGR1_19032775_ChIP-ChIP_M12_Human0.85267721
153SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84303649
154SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83282304
155TP53_23651856_ChIP-Seq_MEFs_Mouse0.82424677
156SOX2_21211035_ChIP-Seq_LN229_Gbm0.82067636
157YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81951969
158TP53_20018659_ChIP-ChIP_R1E_Mouse0.80408184
159CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78767530
160MYC_19915707_ChIP-ChIP_AK7_Human0.78585407
161* SMAD4_21741376_ChIP-Seq_ESCs_Human0.78088812
162RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76995274
163MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76743780
164* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75927807
165TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.74400166
166P53_22127205_ChIP-Seq_FIBROBLAST_Human0.73986860
167NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73137744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.04491634
2MP0005646_abnormal_pituitary_gland3.26910304
3MP0005171_absent_coat_pigmentation2.92049001
4MP0003690_abnormal_glial_cell2.90008320
5MP0006292_abnormal_olfactory_placode2.58682093
6MP0004858_abnormal_nervous_system2.55006398
7MP0000566_synostosis2.54473116
8MP0004859_abnormal_synaptic_plasticity2.45956102
9MP0001486_abnormal_startle_reflex2.39035701
10MP0003879_abnormal_hair_cell2.22523067
11MP0005645_abnormal_hypothalamus_physiol2.20513318
12MP0005423_abnormal_somatic_nervous2.14638179
13MP0009046_muscle_twitch2.13105880
14MP0001968_abnormal_touch/_nociception2.08193065
15MP0001986_abnormal_taste_sensitivity2.04979257
16MP0002736_abnormal_nociception_after2.03560574
17MP0009780_abnormal_chondrocyte_physiolo1.98549436
18MP0003635_abnormal_synaptic_transmissio1.94455024
19MP0002734_abnormal_mechanical_nocicepti1.91931860
20MP0002272_abnormal_nervous_system1.88706857
21MP0003880_abnormal_central_pattern1.87805831
22MP0009745_abnormal_behavioral_response1.86945304
23MP0002735_abnormal_chemical_nociception1.85678301
24MP0002254_reproductive_system_inflammat1.83206096
25MP0003011_delayed_dark_adaptation1.81193213
26MP0002102_abnormal_ear_morphology1.76283739
27MP0002733_abnormal_thermal_nociception1.73829831
28MP0002572_abnormal_emotion/affect_behav1.72532850
29MP0004811_abnormal_neuron_physiology1.72416878
30MP0002064_seizures1.71494560
31MP0005670_abnormal_white_adipose1.66678190
32MP0002067_abnormal_sensory_capabilities1.65691080
33MP0004270_analgesia1.64787331
34MP0004885_abnormal_endolymph1.62815213
35MP0008569_lethality_at_weaning1.62457240
36MP0001970_abnormal_pain_threshold1.60135567
37MP0000920_abnormal_myelination1.59144916
38MP0001984_abnormal_olfaction1.58105950
39MP0002063_abnormal_learning/memory/cond1.57715682
40MP0001502_abnormal_circadian_rhythm1.56838984
41MP0000372_irregular_coat_pigmentation1.53663119
42MP0005379_endocrine/exocrine_gland_phen1.53405773
43MP0003183_abnormal_peptide_metabolism1.52590752
44MP0001440_abnormal_grooming_behavior1.52573084
45MP0003329_amyloid_beta_deposits1.49070583
46MP0003632_abnormal_nervous_system1.48069889
47MP0004742_abnormal_vestibular_system1.47789938
48MP0001905_abnormal_dopamine_level1.46966690
49MP0001501_abnormal_sleep_pattern1.46952032
50MP0005394_taste/olfaction_phenotype1.43549138
51MP0005499_abnormal_olfactory_system1.43549138
52MP0003633_abnormal_nervous_system1.40515087
53MP0004142_abnormal_muscle_tone1.40426293
54MP0003634_abnormal_glial_cell1.40311493
55MP0004381_abnormal_hair_follicle1.39755877
56MP0003631_nervous_system_phenotype1.37903078
57MP0001177_atelectasis1.37342475
58MP0006276_abnormal_autonomic_nervous1.37060093
59MP0000049_abnormal_middle_ear1.36668131
60MP0002638_abnormal_pupillary_reflex1.36173365
61MP0003950_abnormal_plasma_membrane1.34920160
62MP0008260_abnormal_autophagy1.33739891
63MP0002557_abnormal_social/conspecific_i1.31612682
64MP0005253_abnormal_eye_physiology1.30183703
65MP0001963_abnormal_hearing_physiology1.26974912
66MP0003787_abnormal_imprinting1.26363000
67MP0001188_hyperpigmentation1.25726691
68MP0001485_abnormal_pinna_reflex1.25483846
69MP0000026_abnormal_inner_ear1.23159589
70MP0003123_paternal_imprinting1.22719543
71MP0005551_abnormal_eye_electrophysiolog1.20621548
72MP0003075_altered_response_to1.17049804
73MP0000604_amyloidosis1.14655775
74MP0000778_abnormal_nervous_system1.14604688
75MP0005409_darkened_coat_color1.11978401
76MP0002152_abnormal_brain_morphology1.11618315
77MP0004924_abnormal_behavior1.10400965
78MP0005386_behavior/neurological_phenoty1.10400965
79MP0003279_aneurysm1.09549512
80MP0001529_abnormal_vocalization1.09503552
81MP0000579_abnormal_nail_morphology1.07537151
82MP0002752_abnormal_somatic_nervous1.05577783
83MP0002882_abnormal_neuron_morphology1.03638944
84MP0003718_maternal_effect1.01100456
85MP0000955_abnormal_spinal_cord0.99702045
86MP0002184_abnormal_innervation0.98772867
87MP0008874_decreased_physiological_sensi0.98499468
88MP0002249_abnormal_larynx_morphology0.97615537
89MP0003122_maternal_imprinting0.97602280
90MP0003137_abnormal_impulse_conducting0.92185320
91MP0001346_abnormal_lacrimal_gland0.90582169
92MP0008789_abnormal_olfactory_epithelium0.90237535
93MP0009384_cardiac_valve_regurgitation0.89593420
94MP0009764_decreased_sensitivity_to0.89056961
95MP0002229_neurodegeneration0.88967637
96MP0002822_catalepsy0.86274155
97MP0004147_increased_porphyrin_level0.81718868
98MP0002066_abnormal_motor_capabilities/c0.81017670
99MP0001853_heart_inflammation0.79300076
100MP0000383_abnormal_hair_follicle0.78606201
101MP0005535_abnormal_body_temperature0.76108449
102MP0005377_hearing/vestibular/ear_phenot0.74644192
103MP0003878_abnormal_ear_physiology0.74644192
104MP0001348_abnormal_lacrimal_gland0.73166743
105MP0003172_abnormal_lysosome_physiology0.71185437
106MP0003938_abnormal_ear_development0.71041714
107MP0004043_abnormal_pH_regulation0.70423816
108MP0002069_abnormal_eating/drinking_beha0.69479584
109MP0005167_abnormal_blood-brain_barrier0.66805301
110MP0000762_abnormal_tongue_morphology0.65542230
111MP0010386_abnormal_urinary_bladder0.65447935
112MP0009250_abnormal_appendicular_skeleto0.64490611
113MP0002163_abnormal_gland_morphology0.63432558
114MP0002127_abnormal_cardiovascular_syste0.63426653
115MP0003045_fibrosis0.62848087
116MP0005508_abnormal_skeleton_morphology0.62598996
117MP0004130_abnormal_muscle_cell0.61933299
118MP0002089_abnormal_postnatal_growth/wei0.58025687
119MP0005166_decreased_susceptibility_to0.57523135
120MP0001299_abnormal_eye_distance/0.57458017
121MP0010769_abnormal_survival0.55906403
122MP0002909_abnormal_adrenal_gland0.55905058
123MP0008872_abnormal_physiological_respon0.53800652
124MP0005623_abnormal_meninges_morphology0.53210729
125MP0010768_mortality/aging0.52163586
126MP0002653_abnormal_ependyma_morphology0.51030874
127MP0002082_postnatal_lethality0.50931041
128MP0010770_preweaning_lethality0.50931041
129MP0001943_abnormal_respiration0.50357759
130MP0004510_myositis0.49689009
131MP0008877_abnormal_DNA_methylation0.49552781
132MP0003956_abnormal_body_size0.49108297
133MP0003861_abnormal_nervous_system0.48779185
134MP0000747_muscle_weakness0.46867622

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)5.47460875
2Aplasia of the phalanges of the hand (HP:0009802)5.47460875
3Aplasia involving bones of the extremities (HP:0009825)5.47460875
4Ankle clonus (HP:0011448)4.98769725
5Atonic seizures (HP:0010819)4.72192111
6Spastic gait (HP:0002064)4.05430812
7Cerebral hypomyelination (HP:0006808)4.00624225
8Visual hallucinations (HP:0002367)3.94315423
9Abnormal eating behavior (HP:0100738)3.84324017
10Obstructive sleep apnea (HP:0002870)3.80942849
11Annular pancreas (HP:0001734)3.75621758
12Neurofibrillary tangles (HP:0002185)3.65129325
13Dysmetria (HP:0001310)3.57336926
14Intention tremor (HP:0002080)3.53261712
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.51503018
16Hemiparesis (HP:0001269)3.50317230
17Papilledema (HP:0001085)3.42218836
18Focal motor seizures (HP:0011153)3.40360566
19Absence seizures (HP:0002121)3.40034433
20Postural instability (HP:0002172)3.32234667
21Tetraplegia (HP:0002445)3.28610478
22Urinary bladder sphincter dysfunction (HP:0002839)3.28455726
23Aplasia/Hypoplasia of the fovea (HP:0008060)3.25308580
24Hypoplasia of the fovea (HP:0007750)3.25308580
25Truncal ataxia (HP:0002078)3.20203574
26Dialeptic seizures (HP:0011146)3.17781781
27Febrile seizures (HP:0002373)3.15886830
28Torticollis (HP:0000473)3.10740323
29Mutism (HP:0002300)3.04289627
30Limb dystonia (HP:0002451)3.01893603
31Abnormality of the fovea (HP:0000493)2.95007914
32Neuronal loss in central nervous system (HP:0002529)2.93447023
33Urinary urgency (HP:0000012)2.92305399
34Status epilepticus (HP:0002133)2.86904746
35Delusions (HP:0000746)2.84651256
36Scanning speech (HP:0002168)2.82376496
37Abnormality of the corticospinal tract (HP:0002492)2.82001290
38Akinesia (HP:0002304)2.80990101
39Epileptic encephalopathy (HP:0200134)2.80426338
40Increased circulating renin level (HP:0000848)2.79620613
41Chromsome breakage (HP:0040012)2.78878299
42Depression (HP:0000716)2.78782480
43Clonus (HP:0002169)2.78537188
44Megalencephaly (HP:0001355)2.78094335
45Sex reversal (HP:0012245)2.75691197
46Abnormal sex determination (HP:0012244)2.75691197
47Impaired vibration sensation in the lower limbs (HP:0002166)2.70311644
48Lower limb muscle weakness (HP:0007340)2.66776595
49Diplopia (HP:0000651)2.65680664
50Abnormality of binocular vision (HP:0011514)2.65680664
51Insomnia (HP:0100785)2.65197330
52Focal dystonia (HP:0004373)2.63759564
53Supranuclear gaze palsy (HP:0000605)2.63143346
54Dysdiadochokinesis (HP:0002075)2.63037697
55Anxiety (HP:0000739)2.62154653
56Sleep apnea (HP:0010535)2.61865177
57Spastic tetraparesis (HP:0001285)2.59412253
58Poor eye contact (HP:0000817)2.59131380
59Apathy (HP:0000741)2.57481702
60Duplication of thumb phalanx (HP:0009942)2.57169869
61Bradykinesia (HP:0002067)2.56035088
62Rigidity (HP:0002063)2.54441810
63Epileptiform EEG discharges (HP:0011182)2.54290135
64Septo-optic dysplasia (HP:0100842)2.52271362
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.50280634
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50280634
67Choreoathetosis (HP:0001266)2.50153116
68Bilateral microphthalmos (HP:0007633)2.48787742
69Abnormality of the dental pulp (HP:0006479)2.48402564
70Abnormality of molar morphology (HP:0011070)2.46613495
71Abnormality of molar (HP:0011077)2.46613495
72Mixed hearing impairment (HP:0000410)2.44337029
73Abnormality of the axillary hair (HP:0100134)2.43669761
74Abnormality of secondary sexual hair (HP:0009888)2.43669761
75Action tremor (HP:0002345)2.42832819
76Atelectasis (HP:0100750)2.42245775
77Progressive cerebellar ataxia (HP:0002073)2.41531996
78Craniofacial dystonia (HP:0012179)2.41373506
79White forelock (HP:0002211)2.39074558
80Abnormality of the dental root (HP:0006486)2.38105388
81Taurodontia (HP:0000679)2.38105388
82Abnormality of permanent molar morphology (HP:0011071)2.38105388
83Long nose (HP:0003189)2.37870691
84Hemiplegia (HP:0002301)2.36013410
85CNS hypomyelination (HP:0003429)2.32140220
86Median cleft lip (HP:0000161)2.30893673
87Diminished motivation (HP:0000745)2.29785647
88Abnormality of the middle phalanges of the toes (HP:0010183)2.29353697
89Impaired smooth pursuit (HP:0007772)2.23998470
90Stereotypic behavior (HP:0000733)2.23897373
91Rapidly progressive (HP:0003678)2.22866208
92Absent septum pellucidum (HP:0001331)2.22599836
93Impaired social interactions (HP:0000735)2.21985532
94Abnormal social behavior (HP:0012433)2.21985532
95Hypoplastic left heart (HP:0004383)2.21807707
96Clumsiness (HP:0002312)2.20782152
97EEG with generalized epileptiform discharges (HP:0011198)2.20447091
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20100914
99Adrenal hypoplasia (HP:0000835)2.19348552
100Abnormality of the lower motor neuron (HP:0002366)2.17714328
101Aplasia/hypoplasia of the uterus (HP:0008684)2.17179011
102Focal seizures (HP:0007359)2.13000907
103Duplicated collecting system (HP:0000081)2.12544806
104Medial flaring of the eyebrow (HP:0010747)2.09245523
105Amblyopia (HP:0000646)2.09088480
106Patchy hypopigmentation of hair (HP:0011365)2.08900739
107Bundle branch block (HP:0011710)2.08266232
108Abnormality of the periventricular white matter (HP:0002518)2.06809199
109Abnormality of ocular smooth pursuit (HP:0000617)2.04941538
110Lower limb asymmetry (HP:0100559)2.04921025
111Hypsarrhythmia (HP:0002521)2.03534936
112Ulnar claw (HP:0001178)2.03390618
113Hypoplasia of the uterus (HP:0000013)2.02238306
114Anomalous pulmonary venous return (HP:0010772)2.01972355
115True hermaphroditism (HP:0010459)2.01294325
116Pancreatic fibrosis (HP:0100732)2.01149837
117Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.00580131
118Impaired vibratory sensation (HP:0002495)1.99990820
119Hypergonadotropic hypogonadism (HP:0000815)1.99257993
120Turricephaly (HP:0000262)1.99105697
121Morphological abnormality of the inner ear (HP:0011390)1.99066715
122Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.98893617
123Ventricular fibrillation (HP:0001663)1.98542630
124Abnormality of chromosome segregation (HP:0002916)1.98385842
125Spinal canal stenosis (HP:0003416)1.97861735
126Morphological abnormality of the pyramidal tract (HP:0002062)1.96800594
127Partial duplication of thumb phalanx (HP:0009944)1.95727819
128Abnormality of saccadic eye movements (HP:0000570)1.95311958
129Neonatal short-limb short stature (HP:0008921)1.94198309
130Aplasia/Hypoplasia of the macula (HP:0008059)1.93350169
131Gait imbalance (HP:0002141)1.92395726
132Polyphagia (HP:0002591)1.91067095
133Abnormality of the phalanges of the 5th finger (HP:0004213)1.90832642
134Short middle phalanx of the 5th finger (HP:0004220)1.90335936
135Generalized tonic-clonic seizures (HP:0002069)1.90285618
136Myokymia (HP:0002411)1.90192937
137Humeroradial synostosis (HP:0003041)1.89909065
138Synostosis involving the elbow (HP:0003938)1.89909065
139Abnormal ciliary motility (HP:0012262)1.89591118
140Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.87662090
141Pointed chin (HP:0000307)1.87428943
142Narrow nasal bridge (HP:0000446)1.87269131
143Abnormality of the renal collecting system (HP:0004742)1.87048833
144Congenital primary aphakia (HP:0007707)1.86995545
145Bronchomalacia (HP:0002780)1.86792083
146Foot dorsiflexor weakness (HP:0009027)1.84959649
147Heart block (HP:0012722)1.84634613
148Nasolacrimal duct obstruction (HP:0000579)1.84624676
149Nephrogenic diabetes insipidus (HP:0009806)1.84546069
150Supernumerary spleens (HP:0009799)1.84427186
151Genital tract atresia (HP:0001827)1.83976843
152Incomplete penetrance (HP:0003829)1.83882677
153Hypoplastic heart (HP:0001961)1.83323127
154Flat capital femoral epiphysis (HP:0003370)1.82972294
155Optic nerve hypoplasia (HP:0000609)1.82318275
156Split foot (HP:0001839)1.81049578
157Cerebral inclusion bodies (HP:0100314)1.80715791
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80302784
159Dementia (HP:0000726)1.79772953
160Memory impairment (HP:0002354)1.78623495
161Onion bulb formation (HP:0003383)1.78601149
162Segmental peripheral demyelination/remyelination (HP:0003481)1.77753965
163Alacrima (HP:0000522)1.77607150
164Abnormality of the septum pellucidum (HP:0007375)1.75971186
165Anosmia (HP:0000458)1.75066895
166Congenital sensorineural hearing impairment (HP:0008527)1.74316893
167Slow saccadic eye movements (HP:0000514)1.74095144
168Aplasia/Hypoplasia of the lens (HP:0008063)1.71834709
169Abnormality of the pulmonary veins (HP:0011718)1.71205656
170Vaginal atresia (HP:0000148)1.69046086
171Upper limb muscle weakness (HP:0003484)1.68833067
172Hyperventilation (HP:0002883)1.68384251
173Peripheral hypomyelination (HP:0007182)1.68118274
174Nonprogressive disorder (HP:0003680)1.65279099
175Abnormal auditory evoked potentials (HP:0006958)1.64218007
176Aplasia/Hypoplasia affecting the retina (HP:0008061)1.63560045
177Fibular aplasia (HP:0002990)1.63364179
178Postaxial foot polydactyly (HP:0001830)1.63014783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.80528024
2DAPK23.39222567
3UHMK13.35747980
4MUSK2.86065019
5TNIK2.64815097
6BMPR22.62844095
7LMTK22.62027005
8CAMKK12.61689959
9MAP2K72.57469531
10NTRK22.38172456
11ADRBK22.34468838
12GRK52.31149198
13GRK12.25099081
14PHKG22.20341520
15PHKG12.20341520
16MAP3K92.13635370
17SGK2231.98544685
18SGK4941.98544685
19MAPK131.94117180
20RIPK11.91255240
21PINK11.79827134
22SGK21.70016234
23EPHA41.67199799
24INSRR1.65649293
25GRK71.61482276
26NEK61.58750065
27MAPKAPK51.55327231
28MAP3K41.47655784
29NTRK31.47425144
30CAMK2B1.45863738
31CAMK11.44671744
32KSR21.42742522
33WNK11.41152011
34MAPK71.40728848
35SIK21.34610333
36MAP3K131.31202012
37MOS1.27008997
38PRKCH1.23787020
39BLK1.22484578
40PRKD31.21070557
41STK38L1.14621861
42DAPK11.14416272
43CDK151.12711958
44TNK21.12695687
45ALK1.09655843
46IRAK31.07714670
47CDK181.07597142
48NTRK11.05884186
49CDK11A1.04315457
50IRAK11.03462110
51STK391.01079589
52PRKCE1.00746953
53FGFR21.00264049
54MAP3K141.00247273
55IRAK20.99571135
56MAPK120.99288120
57PRKCG0.99112646
58CDK140.99069526
59PAK30.98710796
60BMPR1B0.97706454
61CDK190.96618808
62PKN10.96024034
63SGK30.95377477
64TIE10.95258255
65PLK20.93723393
66YES10.91120084
67MAPK100.90517210
68IRAK40.90083344
69PBK0.89439866
70STK110.89239500
71STK240.88718572
72MARK10.85269398
73CDK30.83901525
74MKNK20.83879113
75CDC42BPA0.82348737
76ADRBK10.81752964
77TXK0.81320070
78MATK0.78674083
79LATS20.76084850
80BRSK10.73897745
81PRPF4B0.73614724
82CAMK2D0.73000172
83EPHB10.72925088
84TRPM70.72693269
85RIPK40.71411641
86DYRK1A0.70927062
87CAMK40.70377401
88PAK60.70090020
89PRKD20.69288889
90PDK10.69244098
91STK380.69123536
92MAP3K110.67101245
93CAMK2A0.67095695
94OXSR10.66827715
95ERBB40.65211502
96PDPK10.64549167
97RPS6KA30.62284813
98FES0.61953326
99DYRK20.61679181
100MINK10.61665201
101STK160.60971848
102HIPK20.60459986
103MAP2K40.59893395
104GRK60.57870813
105TYRO30.57711466
106DAPK30.55376168
107NLK0.55223904
108PRKCZ0.54609145
109SIK30.51562086
110CDK120.51409101
111EPHA30.51266418
112BRAF0.50808871
113PLK40.50542059
114LIMK10.50279129
115ARAF0.48969716
116FYN0.47102334
117PRKCQ0.45922911
118CDK50.45564010
119BCR0.44562039
120TEC0.43474616
121PRKACA0.42986350
122SGK10.42921423
123MAP3K60.42413276
124MAP3K10.42337329
125RET0.41973375
126ERBB30.41636785
127ERBB20.40753296
128MARK20.40644376
129KSR10.40428926
130ROCK20.40064929
131DMPK0.39872397
132CAMKK20.39811312
133MAP3K20.39586931
134PRKD10.39365263
135ROCK10.38974971
136RAF10.38852458
137CAMK2G0.38557901
138ZAK0.37661333
139PRKCA0.37438853
140CSNK1A10.36563182
141EIF2AK20.36397139
142PRKG20.36369104
143TESK10.31777119
144MAPK80.31599297
145BMX0.29743751
146MAPK40.28865015
147PRKG10.28052889
148JAK20.27602170
149SRC0.27242819
150MAP2K60.27228318

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.97919311
2Fatty acid biosynthesis_Homo sapiens_hsa000612.62642226
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.32646103
4Glutamatergic synapse_Homo sapiens_hsa047242.30182173
5Vitamin B6 metabolism_Homo sapiens_hsa007502.29162328
6Ether lipid metabolism_Homo sapiens_hsa005652.14706041
7Taste transduction_Homo sapiens_hsa047422.12265561
8GABAergic synapse_Homo sapiens_hsa047272.09577792
9Steroid biosynthesis_Homo sapiens_hsa001002.03072958
10Morphine addiction_Homo sapiens_hsa050321.90751121
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88547506
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82187675
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79754962
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77165673
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75893462
16Salivary secretion_Homo sapiens_hsa049701.75874043
17Ovarian steroidogenesis_Homo sapiens_hsa049131.74839895
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65467855
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63275942
20Serotonergic synapse_Homo sapiens_hsa047261.62230213
21Circadian entrainment_Homo sapiens_hsa047131.58374514
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.54224349
23Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.52839895
24Olfactory transduction_Homo sapiens_hsa047401.52376125
25Sphingolipid metabolism_Homo sapiens_hsa006001.51774985
26Linoleic acid metabolism_Homo sapiens_hsa005911.47018637
27Arachidonic acid metabolism_Homo sapiens_hsa005901.46052752
28Insulin secretion_Homo sapiens_hsa049111.38786328
29Autoimmune thyroid disease_Homo sapiens_hsa053201.38328615
30Long-term depression_Homo sapiens_hsa047301.36318299
31Synaptic vesicle cycle_Homo sapiens_hsa047211.29787046
32Estrogen signaling pathway_Homo sapiens_hsa049151.29230409
33Circadian rhythm_Homo sapiens_hsa047101.25179268
34Mineral absorption_Homo sapiens_hsa049781.24599474
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.24415093
36Gastric acid secretion_Homo sapiens_hsa049711.23124283
37Glioma_Homo sapiens_hsa052141.16174135
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14157827
39Fatty acid elongation_Homo sapiens_hsa000621.13686710
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10519673
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09198163
42Bile secretion_Homo sapiens_hsa049761.08230839
43cAMP signaling pathway_Homo sapiens_hsa040241.03114146
44Histidine metabolism_Homo sapiens_hsa003401.02000159
45Rheumatoid arthritis_Homo sapiens_hsa053231.01130980
46Calcium signaling pathway_Homo sapiens_hsa040201.00024692
47Dorso-ventral axis formation_Homo sapiens_hsa043200.98305816
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97643685
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95762228
50ErbB signaling pathway_Homo sapiens_hsa040120.93987335
51Ras signaling pathway_Homo sapiens_hsa040140.92837656
52Prion diseases_Homo sapiens_hsa050200.91348831
53GnRH signaling pathway_Homo sapiens_hsa049120.89552305
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88855008
55Cocaine addiction_Homo sapiens_hsa050300.87100784
56Hedgehog signaling pathway_Homo sapiens_hsa043400.85903163
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84674442
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.84612322
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83962534
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82965439
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82585685
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82536276
63VEGF signaling pathway_Homo sapiens_hsa043700.82056234
64Inositol phosphate metabolism_Homo sapiens_hsa005620.81689889
65African trypanosomiasis_Homo sapiens_hsa051430.81626398
66Renin secretion_Homo sapiens_hsa049240.81390119
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80885804
68Type I diabetes mellitus_Homo sapiens_hsa049400.80632016
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79945386
70Other glycan degradation_Homo sapiens_hsa005110.79726795
71Amphetamine addiction_Homo sapiens_hsa050310.79725595
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.79568864
73Graft-versus-host disease_Homo sapiens_hsa053320.79241884
74Cardiac muscle contraction_Homo sapiens_hsa042600.77906091
75Malaria_Homo sapiens_hsa051440.77073581
76Axon guidance_Homo sapiens_hsa043600.74926523
77Pancreatic secretion_Homo sapiens_hsa049720.74272474
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.73588359
79Vibrio cholerae infection_Homo sapiens_hsa051100.73504196
80Oocyte meiosis_Homo sapiens_hsa041140.73257926
81Melanogenesis_Homo sapiens_hsa049160.70533605
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70177424
83Cholinergic synapse_Homo sapiens_hsa047250.70079805
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69586894
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68582563
86Collecting duct acid secretion_Homo sapiens_hsa049660.68219515
87Endocytosis_Homo sapiens_hsa041440.67795009
88MAPK signaling pathway_Homo sapiens_hsa040100.67405317
89Fanconi anemia pathway_Homo sapiens_hsa034600.66923414
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66719122
91Phototransduction_Homo sapiens_hsa047440.66357627
92Basal cell carcinoma_Homo sapiens_hsa052170.66145281
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.65969303
94Long-term potentiation_Homo sapiens_hsa047200.65812656
95Choline metabolism in cancer_Homo sapiens_hsa052310.65102218
96Dopaminergic synapse_Homo sapiens_hsa047280.64681491
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64640275
98beta-Alanine metabolism_Homo sapiens_hsa004100.63713345
99Vitamin digestion and absorption_Homo sapiens_hsa049770.63178207
100Type II diabetes mellitus_Homo sapiens_hsa049300.60961512
101Allograft rejection_Homo sapiens_hsa053300.60407829
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60159502
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59548982
104Arginine and proline metabolism_Homo sapiens_hsa003300.59534612
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58970642
106Fatty acid metabolism_Homo sapiens_hsa012120.56295241
107Glucagon signaling pathway_Homo sapiens_hsa049220.56100998
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54549201
109Oxytocin signaling pathway_Homo sapiens_hsa049210.54347675
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53908758
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53082443
112Lysosome_Homo sapiens_hsa041420.52934758
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50388348
114Gap junction_Homo sapiens_hsa045400.50300546
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.49725213
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47857867
117Regulation of autophagy_Homo sapiens_hsa041400.47012246
118Rap1 signaling pathway_Homo sapiens_hsa040150.46373219
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44382403
120Nitrogen metabolism_Homo sapiens_hsa009100.43753016
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43412513
122Arginine biosynthesis_Homo sapiens_hsa002200.42432849
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42428896
124Thyroid hormone synthesis_Homo sapiens_hsa049180.42282294
125Dilated cardiomyopathy_Homo sapiens_hsa054140.42242640
126Wnt signaling pathway_Homo sapiens_hsa043100.40524047
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38381311
128mTOR signaling pathway_Homo sapiens_hsa041500.36147691
129Alcoholism_Homo sapiens_hsa050340.34867770
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31557661
131Insulin signaling pathway_Homo sapiens_hsa049100.29645483
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27987323
133AMPK signaling pathway_Homo sapiens_hsa041520.27124156
134Endometrial cancer_Homo sapiens_hsa052130.26811282
135Tight junction_Homo sapiens_hsa045300.26388203
136HIF-1 signaling pathway_Homo sapiens_hsa040660.21391890
137Hippo signaling pathway_Homo sapiens_hsa043900.20727192

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