PAQR8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.83160954
2central nervous system myelination (GO:0022010)5.83160954
3L-amino acid import (GO:0043092)5.36257951
4locomotory exploration behavior (GO:0035641)5.26052254
5synaptic vesicle maturation (GO:0016188)4.86701794
6cellular potassium ion homeostasis (GO:0030007)4.67655528
7neuronal action potential propagation (GO:0019227)4.58645919
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.55678125
9gamma-aminobutyric acid transport (GO:0015812)4.53282174
10postsynaptic membrane organization (GO:0001941)4.52751755
11sodium ion export (GO:0071436)4.47617979
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.35906596
13positive regulation of synapse maturation (GO:0090129)4.31881276
14amino acid import (GO:0043090)4.29910079
15cerebellar granule cell differentiation (GO:0021707)4.07359620
16synaptic vesicle exocytosis (GO:0016079)4.06506145
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05381563
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.04537300
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.03358325
20glutamate secretion (GO:0014047)4.01075294
21regulation of synaptic vesicle exocytosis (GO:2000300)3.95783686
22potassium ion import (GO:0010107)3.94796981
23vocalization behavior (GO:0071625)3.88559449
24myelination (GO:0042552)3.88371341
25transmission of nerve impulse (GO:0019226)3.85617325
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.85153228
27axon ensheathment (GO:0008366)3.81904255
28ensheathment of neurons (GO:0007272)3.81904255
29glutamate receptor signaling pathway (GO:0007215)3.72852019
30neuron cell-cell adhesion (GO:0007158)3.69114128
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67977005
32regulation of neuronal synaptic plasticity (GO:0048168)3.65927533
33exploration behavior (GO:0035640)3.65319531
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.64023549
35synaptic transmission, glutamatergic (GO:0035249)3.62367832
36potassium ion homeostasis (GO:0055075)3.57596962
37negative regulation of neurotransmitter transport (GO:0051589)3.57497403
38regulation of synapse maturation (GO:0090128)3.55705618
39dendritic spine morphogenesis (GO:0060997)3.55049280
40neurotransmitter secretion (GO:0007269)3.54835197
41glycine transport (GO:0015816)3.51117470
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.47921051
43neurotransmitter uptake (GO:0001504)3.46444280
44regulation of glutamate receptor signaling pathway (GO:1900449)3.44741547
45layer formation in cerebral cortex (GO:0021819)3.43523286
46adult walking behavior (GO:0007628)3.39840214
47positive regulation of dendritic spine development (GO:0060999)3.38641022
48regulation of synaptic vesicle transport (GO:1902803)3.38409996
49C4-dicarboxylate transport (GO:0015740)3.37847355
50neuron-neuron synaptic transmission (GO:0007270)3.37113816
51dendrite morphogenesis (GO:0048813)3.35385885
52negative regulation of neurotransmitter secretion (GO:0046929)3.34824278
53neuronal ion channel clustering (GO:0045161)3.34703388
54long-term memory (GO:0007616)3.34387560
55cellular sodium ion homeostasis (GO:0006883)3.30957230
56protein localization to synapse (GO:0035418)3.28557603
57fatty acid elongation (GO:0030497)3.25844907
58presynaptic membrane assembly (GO:0097105)3.25191552
59regulation of synapse structural plasticity (GO:0051823)3.24653112
60presynaptic membrane organization (GO:0097090)3.22284108
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21027807
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18167528
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.17812555
64neurotransmitter transport (GO:0006836)3.17362796
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17083616
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15721358
67acidic amino acid transport (GO:0015800)3.12805322
68synaptic vesicle docking involved in exocytosis (GO:0016081)3.10122397
69positive regulation of membrane potential (GO:0045838)3.08626856
70neurotransmitter-gated ion channel clustering (GO:0072578)3.08202036
71response to auditory stimulus (GO:0010996)3.06609367
72cell communication by electrical coupling (GO:0010644)3.06229896
73negative regulation of protein localization to cell surface (GO:2000009)3.05890173
74regulation of female receptivity (GO:0045924)3.05732432
75neuromuscular process controlling balance (GO:0050885)3.03788806
76positive regulation of dendritic spine morphogenesis (GO:0061003)3.03136038
77L-glutamate transport (GO:0015813)3.00607328
78regulation of neurotransmitter transport (GO:0051588)2.99920455
79auditory behavior (GO:0031223)2.98312773
80long-term synaptic potentiation (GO:0060291)2.96810445
81regulation of excitatory postsynaptic membrane potential (GO:0060079)2.96702230
82regulation of neurotransmitter levels (GO:0001505)2.96160836
83sodium ion homeostasis (GO:0055078)2.95929120
84membrane hyperpolarization (GO:0060081)2.93996714
85neuromuscular process controlling posture (GO:0050884)2.93600424
86neuron recognition (GO:0008038)2.92264057
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91575889
88regulation of synaptic plasticity (GO:0048167)2.91115037
89cerebellar Purkinje cell differentiation (GO:0021702)2.90396498
90serotonin metabolic process (GO:0042428)2.90347113
91astrocyte differentiation (GO:0048708)2.88203233
92membrane depolarization during action potential (GO:0086010)2.87915804
93nerve growth factor signaling pathway (GO:0038180)2.87536943
94primary amino compound metabolic process (GO:1901160)2.86739962
95axonal fasciculation (GO:0007413)2.84457928
96membrane repolarization (GO:0086009)2.83635118
97cerebral cortex radially oriented cell migration (GO:0021799)2.82809717
98myelination in peripheral nervous system (GO:0022011)2.82446232
99peripheral nervous system axon ensheathment (GO:0032292)2.82446232
100regulation of dendritic spine morphogenesis (GO:0061001)2.81331182
101regulation of dendritic spine development (GO:0060998)2.79556998
102regulation of postsynaptic membrane potential (GO:0060078)2.78921042
103positive regulation of potassium ion transmembrane transport (GO:1901381)2.77914946
104mechanosensory behavior (GO:0007638)2.77850870
105positive regulation of potassium ion transport (GO:0043268)2.77789729
106long-chain fatty acid biosynthetic process (GO:0042759)2.77689867
107astrocyte development (GO:0014002)2.76815373
108regulation of neurotransmitter secretion (GO:0046928)2.76001894
109cell differentiation in hindbrain (GO:0021533)2.73940769
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73707481
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.73581967
112regulation of voltage-gated calcium channel activity (GO:1901385)2.73530155
113membrane depolarization (GO:0051899)2.71244220
114negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71197567
115negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.70503016
116synaptic vesicle endocytosis (GO:0048488)2.68670802
117proline transport (GO:0015824)2.66396609
118regulation of ARF protein signal transduction (GO:0032012)2.66300490
119regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66107697
120myelin maintenance (GO:0043217)2.63173695
121female mating behavior (GO:0060180)2.61916399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75431163
2GBX2_23144817_ChIP-Seq_PC3_Human3.14664650
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02082928
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89857439
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87153071
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60537203
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60537203
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51564353
9DROSHA_22980978_ChIP-Seq_HELA_Human2.51141675
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46462333
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41502263
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40608091
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40183255
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38254220
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.30581728
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.30423125
17REST_21632747_ChIP-Seq_MESCs_Mouse2.23017187
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.21082753
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.14631557
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14357653
21* RARB_27405468_Chip-Seq_BRAIN_Mouse2.11413904
22AR_21572438_ChIP-Seq_LNCaP_Human2.10979589
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84601454
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80833625
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.78273945
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68309659
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65144350
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62510231
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54087650
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52601198
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52064438
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47562812
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45033557
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44076838
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43953383
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42596545
37SMAD4_21799915_ChIP-Seq_A2780_Human1.42596146
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42454746
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40614632
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37895445
41TAF15_26573619_Chip-Seq_HEK293_Human1.35633747
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34175379
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.34099434
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.31478655
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30807988
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30446518
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.30250686
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29283235
49* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29165788
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29089117
51* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28757614
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26934048
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26668525
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.25323517
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25070407
56STAT3_23295773_ChIP-Seq_U87_Human1.24557955
57P300_19829295_ChIP-Seq_ESCs_Human1.21054124
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20075895
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19344075
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.17550269
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17193298
62ZNF274_21170338_ChIP-Seq_K562_Hela1.16209948
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15898469
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.15614890
65TP53_16413492_ChIP-PET_HCT116_Human1.15090696
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15075041
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14547329
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13267673
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12011676
70* AR_19668381_ChIP-Seq_PC3_Human1.10876053
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.09698664
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09598857
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09330762
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09114830
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08630687
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08512078
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.08250501
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07782421
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07416073
80AR_25329375_ChIP-Seq_VCAP_Human1.07035595
81TCF4_23295773_ChIP-Seq_U87_Human1.06777560
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06722691
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06408443
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.05910686
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05704224
86* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04124648
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.02843505
88RXR_22108803_ChIP-Seq_LS180_Human1.02171624
89* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01909138
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00864697
91ER_23166858_ChIP-Seq_MCF-7_Human0.98917784
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98035300
93AHR_22903824_ChIP-Seq_MCF-7_Human0.97648995
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97495134
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95980154
96KDM2B_26808549_Chip-Seq_K562_Human0.95637810
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.94575738
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93765234
99* EP300_21415370_ChIP-Seq_HL-1_Mouse0.92976773
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.92874214
101CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92278822
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.91157721
103* RUNX2_22187159_ChIP-Seq_PCA_Human0.90938348
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89400252
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89383721
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89370263
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89370263
108FOXA2_19822575_ChIP-Seq_HepG2_Human0.88360045
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87073423
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.86729505
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86191078
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85767038
113TP53_18474530_ChIP-ChIP_U2OS_Human0.85320010
114RNF2_27304074_Chip-Seq_NSC_Mouse0.84153257
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84120978
116SMAD4_21741376_ChIP-Seq_EPCs_Human0.83671199
117CTCF_27219007_Chip-Seq_Bcells_Human0.80691005
118ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80595536
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80565161
120KDM2B_26808549_Chip-Seq_REH_Human0.79251103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.45194323
2MP0003880_abnormal_central_pattern4.06103670
3MP0004270_analgesia3.93963951
4MP0003635_abnormal_synaptic_transmissio3.61088290
5MP0009046_muscle_twitch3.28052112
6MP0002064_seizures3.09056969
7MP0005423_abnormal_somatic_nervous3.07704982
8MP0009745_abnormal_behavioral_response3.01821657
9MP0001486_abnormal_startle_reflex2.94789241
10MP0004885_abnormal_endolymph2.94245259
11MP0002272_abnormal_nervous_system2.84475896
12MP0002063_abnormal_learning/memory/cond2.74016484
13MP0000920_abnormal_myelination2.72899910
14MP0003690_abnormal_glial_cell2.68026377
15MP0002734_abnormal_mechanical_nocicepti2.47128961
16MP0002572_abnormal_emotion/affect_behav2.42849040
17MP0003329_amyloid_beta_deposits2.41894390
18MP0001968_abnormal_touch/_nociception2.32274934
19MP0008569_lethality_at_weaning2.30212763
20MP0001440_abnormal_grooming_behavior2.16709998
21MP0000778_abnormal_nervous_system2.08817429
22MP0002067_abnormal_sensory_capabilities1.97201573
23MP0001485_abnormal_pinna_reflex1.93302985
24MP0003122_maternal_imprinting1.90465871
25MP0004858_abnormal_nervous_system1.85214872
26MP0004147_increased_porphyrin_level1.83694169
27MP0002736_abnormal_nociception_after1.83157731
28MP0001501_abnormal_sleep_pattern1.78666937
29MP0004142_abnormal_muscle_tone1.76844337
30MP0003634_abnormal_glial_cell1.75535035
31MP0009780_abnormal_chondrocyte_physiolo1.74820276
32MP0000955_abnormal_spinal_cord1.72235505
33MP0002733_abnormal_thermal_nociception1.72138145
34MP0004742_abnormal_vestibular_system1.69982284
35MP0001970_abnormal_pain_threshold1.69785176
36MP0003633_abnormal_nervous_system1.68427149
37MP0002822_catalepsy1.64825357
38MP0003632_abnormal_nervous_system1.58242169
39MP0005646_abnormal_pituitary_gland1.55922975
40MP0003631_nervous_system_phenotype1.55585496
41MP0005386_behavior/neurological_phenoty1.55153498
42MP0004924_abnormal_behavior1.55153498
43MP0003183_abnormal_peptide_metabolism1.54792464
44MP0002882_abnormal_neuron_morphology1.54162441
45MP0002735_abnormal_chemical_nociception1.52116065
46MP0002557_abnormal_social/conspecific_i1.50480276
47MP0001905_abnormal_dopamine_level1.48193013
48MP0002066_abnormal_motor_capabilities/c1.47310898
49MP0002184_abnormal_innervation1.42760963
50MP0004811_abnormal_neuron_physiology1.37425737
51MP0002229_neurodegeneration1.37171534
52MP0003123_paternal_imprinting1.35484050
53MP0001986_abnormal_taste_sensitivity1.32920270
54MP0002638_abnormal_pupillary_reflex1.28527863
55MP0001299_abnormal_eye_distance/1.25665118
56MP0001529_abnormal_vocalization1.21432440
57MP0002152_abnormal_brain_morphology1.18627526
58MP0005409_darkened_coat_color1.18377669
59MP0001177_atelectasis1.17905627
60MP0003866_abnormal_defecation1.17435975
61MP0005623_abnormal_meninges_morphology1.17051680
62MP0001963_abnormal_hearing_physiology1.15650083
63MP0005085_abnormal_gallbladder_physiolo1.15317703
64MP0001502_abnormal_circadian_rhythm1.14672827
65MP0005410_abnormal_fertilization1.10865829
66MP0009379_abnormal_foot_pigmentation1.09165647
67MP0005551_abnormal_eye_electrophysiolog1.08868811
68MP0000604_amyloidosis1.08098653
69MP0005360_urolithiasis1.07953089
70MP0001984_abnormal_olfaction1.07681014
71MP0005171_absent_coat_pigmentation1.06720522
72MP0005645_abnormal_hypothalamus_physiol1.05901358
73MP0004043_abnormal_pH_regulation1.05309332
74MP0003950_abnormal_plasma_membrane1.04764145
75MP0002139_abnormal_hepatobiliary_system1.01181393
76MP0002876_abnormal_thyroid_physiology0.98763372
77MP0001666_abnormal_nutrient_absorption0.98619602
78MP0004145_abnormal_muscle_electrophysio0.95278684
79MP0003136_yellow_coat_color0.95030483
80MP0001765_abnormal_ion_homeostasis0.92756781
81MP0003879_abnormal_hair_cell0.92381351
82MP0002752_abnormal_somatic_nervous0.91709056
83MP0003121_genomic_imprinting0.91044478
84MP0002909_abnormal_adrenal_gland0.91014157
85MP0003075_altered_response_to0.90676342
86MP0005167_abnormal_blood-brain_barrier0.90596802
87MP0010329_abnormal_lipoprotein_level0.81905575
88MP0006276_abnormal_autonomic_nervous0.79617055
89MP0003172_abnormal_lysosome_physiology0.79400032
90MP0005365_abnormal_bile_salt0.79336758
91MP0003283_abnormal_digestive_organ0.78693126
92MP0002090_abnormal_vision0.78406087
93MP0004019_abnormal_vitamin_homeostasis0.77901353
94MP0003137_abnormal_impulse_conducting0.76353498
95MP0002653_abnormal_ependyma_morphology0.75885650
96MP0000566_synostosis0.75303937
97MP0000026_abnormal_inner_ear0.74826708
98MP0000631_abnormal_neuroendocrine_gland0.74794521
99MP0000462_abnormal_digestive_system0.74430115
100MP0000569_abnormal_digit_pigmentation0.73673855
101MP0010678_abnormal_skin_adnexa0.72053939
102MP0006082_CNS_inflammation0.71435532
103MP0002069_abnormal_eating/drinking_beha0.70153798
104MP0001188_hyperpigmentation0.69861489
105MP0008874_decreased_physiological_sensi0.69315630
106MP0005671_abnormal_response_to0.67955363
107MP0005174_abnormal_tail_pigmentation0.67444263
108MP0005166_decreased_susceptibility_to0.66623144
109MP0005535_abnormal_body_temperature0.66400737
110MP0004130_abnormal_muscle_cell0.66369764
111MP0010386_abnormal_urinary_bladder0.65344827
112MP0003938_abnormal_ear_development0.64909854
113MP0008872_abnormal_physiological_respon0.64403846
114MP0000751_myopathy0.64068160
115MP0000747_muscle_weakness0.63746455
116MP0001943_abnormal_respiration0.63012469
117MP0003787_abnormal_imprinting0.62142255
118MP0003861_abnormal_nervous_system0.61870715
119MP0005253_abnormal_eye_physiology0.60865780
120MP0006072_abnormal_retinal_apoptosis0.60690120
121MP0004085_abnormal_heartbeat0.60010251
122MP0002089_abnormal_postnatal_growth/wei0.59418429
123MP0003878_abnormal_ear_physiology0.58059900
124MP0005377_hearing/vestibular/ear_phenot0.58059900
125MP0004134_abnormal_chest_morphology0.57932736
126MP0001664_abnormal_digestion0.57475853
127MP0010769_abnormal_survival0.55851425
128MP0000579_abnormal_nail_morphology0.54802017
129MP0002082_postnatal_lethality0.51903849
130MP0010770_preweaning_lethality0.51903849

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.47667671
2Myokymia (HP:0002411)5.27573774
3Action tremor (HP:0002345)4.69573226
4Neurofibrillary tangles (HP:0002185)4.59453930
5Supranuclear gaze palsy (HP:0000605)4.23667206
6Focal seizures (HP:0007359)4.19648049
7Megalencephaly (HP:0001355)4.14709717
8Progressive cerebellar ataxia (HP:0002073)4.06727492
9Aplasia involving bones of the extremities (HP:0009825)3.96060573
10Aplasia involving bones of the upper limbs (HP:0009823)3.96060573
11Aplasia of the phalanges of the hand (HP:0009802)3.96060573
12Intention tremor (HP:0002080)3.93194762
13Dysmetria (HP:0001310)3.70803364
14Epileptic encephalopathy (HP:0200134)3.70511683
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.63495315
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.63495315
17Atonic seizures (HP:0010819)3.58152849
18Cerebral inclusion bodies (HP:0100314)3.57794115
19Ankle clonus (HP:0011448)3.55254466
20Dysdiadochokinesis (HP:0002075)3.48335787
21Abnormality of the corticospinal tract (HP:0002492)3.44923791
22Visual hallucinations (HP:0002367)3.40763793
23Abnormality of renin-angiotensin system (HP:0000847)3.37972165
24Scanning speech (HP:0002168)3.34220008
25Peripheral hypomyelination (HP:0007182)3.33008041
26Spastic gait (HP:0002064)3.20378420
27Hemiparesis (HP:0001269)3.19045136
28Gaze-evoked nystagmus (HP:0000640)3.12568311
29Papilledema (HP:0001085)3.11020048
30Diplopia (HP:0000651)3.08532299
31Abnormality of binocular vision (HP:0011514)3.08532299
32Generalized tonic-clonic seizures (HP:0002069)2.97912049
33Hemiplegia (HP:0002301)2.93892294
34Insidious onset (HP:0003587)2.91018337
35Termporal pattern (HP:0011008)2.91018337
36Confusion (HP:0001289)2.88839188
37Absence seizures (HP:0002121)2.87362072
38Decreased circulating renin level (HP:0003351)2.84726547
39Dialeptic seizures (HP:0011146)2.84251310
40Postural instability (HP:0002172)2.82052008
41Truncal ataxia (HP:0002078)2.79158925
42Broad-based gait (HP:0002136)2.73530548
43Annular pancreas (HP:0001734)2.72035119
44Abnormal eating behavior (HP:0100738)2.72016206
45Hyperaldosteronism (HP:0000859)2.67243928
46Limb dystonia (HP:0002451)2.66761325
47Increased circulating renin level (HP:0000848)2.65676792
48Urinary bladder sphincter dysfunction (HP:0002839)2.64874580
49Alkalosis (HP:0001948)2.61689685
50Febrile seizures (HP:0002373)2.60266898
51Pheochromocytoma (HP:0002666)2.56131499
52Urinary urgency (HP:0000012)2.54650427
53Impaired vibration sensation in the lower limbs (HP:0002166)2.52461920
54Depression (HP:0000716)2.51269329
55Clumsiness (HP:0002312)2.49186411
56Hyperactive renin-angiotensin system (HP:0000841)2.47922276
57Onion bulb formation (HP:0003383)2.46570869
58Anxiety (HP:0000739)2.44026974
59Cerebral hypomyelination (HP:0006808)2.43758897
60Lower limb muscle weakness (HP:0007340)2.39771562
61Sensory axonal neuropathy (HP:0003390)2.35298687
62Retinal dysplasia (HP:0007973)2.34271417
63Humeroradial synostosis (HP:0003041)2.28680529
64Synostosis involving the elbow (HP:0003938)2.28680529
65Hyperventilation (HP:0002883)2.28102578
66Split foot (HP:0001839)2.27538260
67Clonus (HP:0002169)2.22552297
68Alacrima (HP:0000522)2.22419434
69Abnormality of the middle phalanges of the toes (HP:0010183)2.20969154
70Abnormality of saccadic eye movements (HP:0000570)2.20420752
71Neuroendocrine neoplasm (HP:0100634)2.19854348
72Genetic anticipation (HP:0003743)2.19649746
73Hypokalemic alkalosis (HP:0001949)2.18306618
74Ventricular fibrillation (HP:0001663)2.16755202
75Abnormality of the periventricular white matter (HP:0002518)2.15649561
76Amblyopia (HP:0000646)2.13461313
77Mutism (HP:0002300)2.13423570
78Slow saccadic eye movements (HP:0000514)2.09271956
79Thickened helices (HP:0000391)2.08288539
80Epileptiform EEG discharges (HP:0011182)2.08119443
81Poor eye contact (HP:0000817)2.06486290
82Anteriorly placed anus (HP:0001545)2.04261678
83Polyphagia (HP:0002591)2.01650769
84Abnormality of glutamine family amino acid metabolism (HP:0010902)2.00508577
85Morphological abnormality of the inner ear (HP:0011390)1.98932646
86Neuronal loss in central nervous system (HP:0002529)1.96571750
87Akinesia (HP:0002304)1.96121814
88Postural tremor (HP:0002174)1.95413024
89Progressive inability to walk (HP:0002505)1.95385522
90Generalized myoclonic seizures (HP:0002123)1.93796216
91Impaired smooth pursuit (HP:0007772)1.93197183
92Abnormal social behavior (HP:0012433)1.92128101
93Impaired social interactions (HP:0000735)1.92128101
94Congenital sensorineural hearing impairment (HP:0008527)1.91185903
95Excessive salivation (HP:0003781)1.90849292
96Drooling (HP:0002307)1.90849292
97Memory impairment (HP:0002354)1.90267147
98Hyperglycinuria (HP:0003108)1.89945230
99Fetal akinesia sequence (HP:0001989)1.89909162
100Coronal craniosynostosis (HP:0004440)1.89072661
101Aqueductal stenosis (HP:0002410)1.88952929
102Obstructive sleep apnea (HP:0002870)1.88147890
103Hypokalemia (HP:0002900)1.86863097
104Metabolic alkalosis (HP:0200114)1.86007307
105Stereotypic behavior (HP:0000733)1.85928441
106Mixed hearing impairment (HP:0000410)1.83791148
107Status epilepticus (HP:0002133)1.83534537
108Spastic tetraparesis (HP:0001285)1.82907316
109Gait ataxia (HP:0002066)1.82161955
110Syncope (HP:0001279)1.80370321
111Abnormality of ocular smooth pursuit (HP:0000617)1.79509828
112Bradykinesia (HP:0002067)1.79344212
113Abnormality of cochlea (HP:0000375)1.78808200
114Choreoathetosis (HP:0001266)1.77834524
115Morphological abnormality of the pyramidal tract (HP:0002062)1.77184252
116EEG with generalized epileptiform discharges (HP:0011198)1.76998572
117Focal dystonia (HP:0004373)1.76895266
118Adrenal overactivity (HP:0002717)1.76828560
119Rigidity (HP:0002063)1.74962329
120Facial shape deformation (HP:0011334)1.74852262
121Potter facies (HP:0002009)1.74852262
122Relative macrocephaly (HP:0004482)1.74546362
123Insomnia (HP:0100785)1.74542648
124Psychosis (HP:0000709)1.74232658
125Impaired vibratory sensation (HP:0002495)1.73392270
126Sleep apnea (HP:0010535)1.72158437
127Hammertoe (HP:0001765)1.71734417
128Amyotrophic lateral sclerosis (HP:0007354)1.70847493
129Delusions (HP:0000746)1.70548229
130Decreased lacrimation (HP:0000633)1.70429642
131Torticollis (HP:0000473)1.70204093
132Tetraplegia (HP:0002445)1.69282142
133Hypsarrhythmia (HP:0002521)1.68318179
134Absent speech (HP:0001344)1.67501842
135Abnormality of magnesium homeostasis (HP:0004921)1.64341736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.42681337
2EPHA43.29751631
3STK393.24331402
4NTRK32.99196082
5OXSR12.64015644
6PAK62.40622729
7MAP3K92.40132262
8NTRK22.40053286
9PRKD32.25002979
10MARK12.21376394
11NTRK12.12980076
12CDK192.11490912
13MINK12.04921009
14MAP3K42.01767087
15WNK11.92767237
16FGFR21.80573085
17PRPF4B1.80387711
18LMTK21.74558885
19UHMK11.67647920
20ACVR1B1.67600602
21SIK21.66940073
22TYRO31.65247794
23PIK3CA1.64581011
24EPHB11.50712622
25SGK2231.50664132
26SGK4941.50664132
27MAP2K71.50016627
28KSR21.45432732
29CDK51.44751694
30PHKG11.42913654
31PHKG21.42913654
32CAMKK11.40490219
33PNCK1.38365772
34MAPKAPK51.35278010
35NEK61.35130915
36CASK1.31181477
37DAPK21.30091013
38WNK41.28079554
39MAPK131.25561388
40WNK31.25555337
41BCR1.21880284
42ROCK21.17172201
43ICK1.12939234
44FRK1.12538747
45MAP2K41.10070074
46CAMK2B1.08057096
47FGFR31.07023167
48CAMKK21.06319768
49PKN11.02026298
50CDK141.00128715
51CDK150.99449534
52PAK30.99001787
53CAMK2A0.96437375
54PRKCG0.96161824
55CDK180.95834457
56CSNK1G20.94449871
57STK380.90738630
58STK110.90047533
59ERBB20.89506678
60FES0.86031961
61CDK11A0.85981223
62FGR0.85927581
63CAMK2D0.84423595
64CAMK2G0.84306944
65PINK10.84133182
66PRKCH0.83791711
67GRK50.82940863
68ARAF0.82127575
69CAMK1G0.81996717
70SGK20.81868076
71MAP3K20.81612496
72MARK20.79976371
73PLK20.79484044
74DAPK10.78249270
75SGK30.77850261
76RIPK40.76972205
77KSR10.75637735
78CAMK10.73136655
79DDR20.71770684
80PRKCZ0.71659821
81MET0.71555091
82PRKG20.70465460
83CSNK1A1L0.69986265
84PDPK10.69893664
85RET0.69265931
86CAMK40.68555658
87LIMK10.68226277
88FYN0.65021589
89CSNK1G30.64270763
90ALK0.60817316
91BMPR20.60796185
92DYRK1A0.60754360
93SYK0.60548934
94MAP3K130.59836561
95DMPK0.59605792
96MUSK0.59513967
97SGK10.59043892
98PRKCE0.57860077
99PDK10.57714002
100PTK2B0.56534571
101MAPK120.55010591
102FGFR40.54259730
103PRKCQ0.53264666
104ROCK10.52591914
105PRKD10.52445455
106ITK0.50865615
107RIPK10.49310834
108JAK10.49141469
109PRKCA0.48894006
110MAP3K10.46904386
111RPS6KA30.46698304
112BMX0.46082435
113MAPK100.45573674
114CSNK1G10.45333927
115TNK20.44916549
116GRK10.44814002
117MAP3K120.44317828
118PRKG10.43672892
119TXK0.43020835
120MAP3K110.42492513
121PRKACA0.42353915
122JAK20.41950143
123PRKACG0.41397907
124SRC0.40701807
125MAP4K10.40008658
126CDC42BPA0.37145882
127CSNK1A10.36619105

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.51538390
2Nicotine addiction_Homo sapiens_hsa050333.05661340
3Glutamatergic synapse_Homo sapiens_hsa047242.60596010
4GABAergic synapse_Homo sapiens_hsa047272.60236852
5Synaptic vesicle cycle_Homo sapiens_hsa047212.34121356
6Circadian entrainment_Homo sapiens_hsa047132.30950608
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30677011
8Salivary secretion_Homo sapiens_hsa049702.16500968
9Morphine addiction_Homo sapiens_hsa050322.13746515
10Long-term potentiation_Homo sapiens_hsa047202.09365932
11Histidine metabolism_Homo sapiens_hsa003402.03632960
12Gastric acid secretion_Homo sapiens_hsa049712.03297710
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.98372891
14Olfactory transduction_Homo sapiens_hsa047401.91939791
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88570288
16Long-term depression_Homo sapiens_hsa047301.79374285
17Amphetamine addiction_Homo sapiens_hsa050311.76513392
18Dopaminergic synapse_Homo sapiens_hsa047281.68559698
19Insulin secretion_Homo sapiens_hsa049111.66538767
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63266254
21Cholinergic synapse_Homo sapiens_hsa047251.54890369
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51036034
23Serotonergic synapse_Homo sapiens_hsa047261.49348293
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45484075
25Taste transduction_Homo sapiens_hsa047421.42562374
26Axon guidance_Homo sapiens_hsa043601.41976740
27Fatty acid biosynthesis_Homo sapiens_hsa000611.40675952
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40268474
29Fat digestion and absorption_Homo sapiens_hsa049751.37009408
30Steroid biosynthesis_Homo sapiens_hsa001001.35940484
31Renin secretion_Homo sapiens_hsa049241.35780886
32Cocaine addiction_Homo sapiens_hsa050301.35666598
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.30144846
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27436867
35Dorso-ventral axis formation_Homo sapiens_hsa043201.25858233
36Calcium signaling pathway_Homo sapiens_hsa040201.25589306
37Oxytocin signaling pathway_Homo sapiens_hsa049211.23653238
38cAMP signaling pathway_Homo sapiens_hsa040241.20734396
39Ether lipid metabolism_Homo sapiens_hsa005651.17595890
40Gap junction_Homo sapiens_hsa045401.16967579
41Pancreatic secretion_Homo sapiens_hsa049721.14122262
42GnRH signaling pathway_Homo sapiens_hsa049121.12697032
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.09517013
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07506156
45Fatty acid elongation_Homo sapiens_hsa000621.07404301
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05971285
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03794872
48ErbB signaling pathway_Homo sapiens_hsa040121.01934126
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00129350
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96749792
51Arginine and proline metabolism_Homo sapiens_hsa003300.95152587
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91185614
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.90812328
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90234623
55Estrogen signaling pathway_Homo sapiens_hsa049150.89382182
56Cardiac muscle contraction_Homo sapiens_hsa042600.88990110
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88663874
58Arginine biosynthesis_Homo sapiens_hsa002200.88552254
59Melanogenesis_Homo sapiens_hsa049160.87586846
60Collecting duct acid secretion_Homo sapiens_hsa049660.83937994
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82834933
62Vitamin digestion and absorption_Homo sapiens_hsa049770.81061475
63Bile secretion_Homo sapiens_hsa049760.80896235
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.80606048
65Thyroid hormone synthesis_Homo sapiens_hsa049180.80500227
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80112796
67PPAR signaling pathway_Homo sapiens_hsa033200.80082468
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78586635
69Glioma_Homo sapiens_hsa052140.78393845
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76976638
71Type II diabetes mellitus_Homo sapiens_hsa049300.76408376
72Choline metabolism in cancer_Homo sapiens_hsa052310.76209580
73Renal cell carcinoma_Homo sapiens_hsa052110.75425240
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74721968
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73577474
76Endocytosis_Homo sapiens_hsa041440.72751058
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72356895
78Phototransduction_Homo sapiens_hsa047440.71747637
79Mineral absorption_Homo sapiens_hsa049780.70905620
80Ras signaling pathway_Homo sapiens_hsa040140.69063714
81Glycerolipid metabolism_Homo sapiens_hsa005610.68219673
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68147625
83Protein digestion and absorption_Homo sapiens_hsa049740.66550332
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65796762
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65543712
86Dilated cardiomyopathy_Homo sapiens_hsa054140.65004896
87Vibrio cholerae infection_Homo sapiens_hsa051100.64567381
88MAPK signaling pathway_Homo sapiens_hsa040100.60933678
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60037847
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.59736216
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58723714
92Renin-angiotensin system_Homo sapiens_hsa046140.58695485
93Tight junction_Homo sapiens_hsa045300.56631986
94Butanoate metabolism_Homo sapiens_hsa006500.55429747
95Rap1 signaling pathway_Homo sapiens_hsa040150.54822680
96Linoleic acid metabolism_Homo sapiens_hsa005910.54665182
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.53758345
98Ovarian steroidogenesis_Homo sapiens_hsa049130.53632974
99Inositol phosphate metabolism_Homo sapiens_hsa005620.51421608
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50555892
101Sphingolipid metabolism_Homo sapiens_hsa006000.48710308
102Oocyte meiosis_Homo sapiens_hsa041140.48614852
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.48318514
104beta-Alanine metabolism_Homo sapiens_hsa004100.45560299
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43957366
106Fatty acid metabolism_Homo sapiens_hsa012120.43914186
107Hedgehog signaling pathway_Homo sapiens_hsa043400.43852565
108Wnt signaling pathway_Homo sapiens_hsa043100.42793747
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42565346
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42405079
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42289677
112VEGF signaling pathway_Homo sapiens_hsa043700.41695529
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41525550
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40428510
115Tryptophan metabolism_Homo sapiens_hsa003800.40333713
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.40322228
117Fatty acid degradation_Homo sapiens_hsa000710.39834805
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39086260
119ABC transporters_Homo sapiens_hsa020100.38865837
120Type I diabetes mellitus_Homo sapiens_hsa049400.37683158
121Alcoholism_Homo sapiens_hsa050340.37081652
122Chemical carcinogenesis_Homo sapiens_hsa052040.35972865
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35385264
124Chemokine signaling pathway_Homo sapiens_hsa040620.35134802
125Retinol metabolism_Homo sapiens_hsa008300.34326483
126Sulfur metabolism_Homo sapiens_hsa009200.34225119
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33318119

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