PARD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.84650472
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.84650472
3L-phenylalanine metabolic process (GO:0006558)4.50436696
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.50436696
5aromatic amino acid family catabolic process (GO:0009074)3.88498308
6bile acid biosynthetic process (GO:0006699)3.71747254
7cysteine metabolic process (GO:0006534)3.71214120
8glyoxylate metabolic process (GO:0046487)3.70416559
9mitotic chromosome condensation (GO:0007076)3.47188646
10negative regulation of fibrinolysis (GO:0051918)3.39894488
11sulfur amino acid catabolic process (GO:0000098)3.38572978
12regulation of fibrinolysis (GO:0051917)3.37379099
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.36720230
14bile acid metabolic process (GO:0008206)3.22434674
15peptidyl-glutamic acid carboxylation (GO:0017187)3.18129831
16protein carboxylation (GO:0018214)3.18129831
17fatty acid elongation (GO:0030497)3.17942102
18urea cycle (GO:0000050)3.16006626
19urea metabolic process (GO:0019627)3.16006626
20regulation of protein activation cascade (GO:2000257)3.15575394
21tyrosine metabolic process (GO:0006570)3.15083315
22kynurenine metabolic process (GO:0070189)3.14675358
23serine family amino acid catabolic process (GO:0009071)3.13823651
24high-density lipoprotein particle remodeling (GO:0034375)3.13223601
25hippo signaling (GO:0035329)3.13150013
26paraxial mesoderm development (GO:0048339)3.11996379
27alpha-linolenic acid metabolic process (GO:0036109)3.11862191
28cellular glucuronidation (GO:0052695)3.10980124
29homocysteine metabolic process (GO:0050667)3.05755031
30indole-containing compound catabolic process (GO:0042436)3.04075596
31indolalkylamine catabolic process (GO:0046218)3.04075596
32tryptophan catabolic process (GO:0006569)3.04075596
33tryptophan metabolic process (GO:0006568)3.02465979
34epoxygenase P450 pathway (GO:0019373)3.02130563
35acylglycerol homeostasis (GO:0055090)2.99557477
36triglyceride homeostasis (GO:0070328)2.99557477
37hemidesmosome assembly (GO:0031581)2.94705530
38regulation of complement activation (GO:0030449)2.94076563
39notochord development (GO:0030903)2.92650539
40nuclear pore complex assembly (GO:0051292)2.88779590
41desmosome organization (GO:0002934)2.88170811
42drug catabolic process (GO:0042737)2.87015438
43regulation of bile acid biosynthetic process (GO:0070857)2.86579362
44cellular ketone body metabolic process (GO:0046950)2.84866148
45negative regulation of lipase activity (GO:0060192)2.84426844
46response to nitrosative stress (GO:0051409)2.83565234
47coenzyme catabolic process (GO:0009109)2.82096565
48aromatic amino acid family metabolic process (GO:0009072)2.81995033
49nitrogen cycle metabolic process (GO:0071941)2.80857787
50amino-acid betaine metabolic process (GO:0006577)2.80831895
51complement activation, alternative pathway (GO:0006957)2.80284761
52uronic acid metabolic process (GO:0006063)2.78949672
53glucuronate metabolic process (GO:0019585)2.78949672
54bile acid and bile salt transport (GO:0015721)2.77854375
55fibrinolysis (GO:0042730)2.77728944
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77463441
57lateral sprouting from an epithelium (GO:0060601)2.75291833
58ethanol oxidation (GO:0006069)2.72506593
59regulation of triglyceride catabolic process (GO:0010896)2.72430269
60establishment of tissue polarity (GO:0007164)2.72295954
61establishment of planar polarity (GO:0001736)2.72295954
62gap junction assembly (GO:0016264)2.71231779
63reverse cholesterol transport (GO:0043691)2.71097307
64regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.70306087
65positive regulation of fatty acid beta-oxidation (GO:0032000)2.65910595
66regulation of transforming growth factor beta2 production (GO:0032909)2.65325850
67alpha-amino acid catabolic process (GO:1901606)2.65187739
68regulation of cholesterol esterification (GO:0010872)2.64556199
69serine family amino acid metabolic process (GO:0009069)2.62987293
70epithelial cell-cell adhesion (GO:0090136)2.61261545
71bundle of His cell to Purkinje myocyte communication (GO:0086069)2.61105223
72regulation of cardioblast differentiation (GO:0051890)2.60900794
73Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.59834589
74convergent extension (GO:0060026)2.59654192
75nuclear pore organization (GO:0006999)2.58630966
76regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57662228
77regulation of cholesterol biosynthetic process (GO:0045540)2.57536427
78embryonic foregut morphogenesis (GO:0048617)2.57321204
79glutamate metabolic process (GO:0006536)2.56449715
80regulation of hippo signaling (GO:0035330)2.56034015
81somite development (GO:0061053)2.54125051
82phospholipid efflux (GO:0033700)2.53464325
83intestinal cholesterol absorption (GO:0030299)2.52113005
84positive regulation of catenin import into nucleus (GO:0035413)2.51289456
85acetyl-CoA metabolic process (GO:0006084)2.51231106
86midgut development (GO:0007494)2.51073259
87mitotic sister chromatid cohesion (GO:0007064)2.50832536
88very long-chain fatty acid metabolic process (GO:0000038)2.50601595
89ketone body metabolic process (GO:1902224)2.49565404
90regulation of cholesterol homeostasis (GO:2000188)2.49374960
91serine family amino acid biosynthetic process (GO:0009070)2.49130120
92cellular amino acid catabolic process (GO:0009063)2.48894961
93regulation of establishment of planar polarity (GO:0090175)2.48548149
94plasma lipoprotein particle remodeling (GO:0034369)2.47909499
95protein-lipid complex remodeling (GO:0034368)2.47909499
96macromolecular complex remodeling (GO:0034367)2.47909499
97lysine metabolic process (GO:0006553)2.47665080
98lysine catabolic process (GO:0006554)2.47665080
99glycine metabolic process (GO:0006544)2.47175103
100G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.45531892
101cholesterol homeostasis (GO:0042632)2.44235403
102apical protein localization (GO:0045176)2.44122531
103cholesterol efflux (GO:0033344)2.43521456
104sterol homeostasis (GO:0055092)2.43440204
105cholesterol biosynthetic process (GO:0006695)2.43087624
106branching involved in salivary gland morphogenesis (GO:0060445)2.42907289
107heterochromatin organization (GO:0070828)2.41841323
108negative regulation of protein activation cascade (GO:2000258)2.41476495
109cellular modified amino acid catabolic process (GO:0042219)2.40862067
110non-canonical Wnt signaling pathway (GO:0035567)2.40467409
111retinal metabolic process (GO:0042574)2.39836235
112negative regulation of keratinocyte proliferation (GO:0010839)2.39267571
113embryonic retina morphogenesis in camera-type eye (GO:0060059)2.38670829
114heme transport (GO:0015886)2.38206962
115negative regulation of fatty acid biosynthetic process (GO:0045717)2.38003374
116dorsal/ventral axis specification (GO:0009950)2.37688928
117establishment of apical/basal cell polarity (GO:0035089)2.37245146
118fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.36530586
119benzene-containing compound metabolic process (GO:0042537)2.35848764
120linoleic acid metabolic process (GO:0043651)2.35562513
121polarized epithelial cell differentiation (GO:0030859)2.34938239
122anterior/posterior axis specification, embryo (GO:0008595)2.34715532
123intestinal absorption (GO:0050892)2.34652718
124glycerophospholipid catabolic process (GO:0046475)2.33808297
125glutathione derivative biosynthetic process (GO:1901687)2.33160655
126glutathione derivative metabolic process (GO:1901685)2.33160655
127establishment of skin barrier (GO:0061436)2.32510513
128regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.28565643
129regulation of gene silencing by RNA (GO:0060966)2.28263557
130regulation of posttranscriptional gene silencing (GO:0060147)2.28263557
131regulation of gene silencing by miRNA (GO:0060964)2.28263557
132otic vesicle formation (GO:0030916)2.28011117
133establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.27784563
134axon extension involved in axon guidance (GO:0048846)2.25712396
135neuron projection extension involved in neuron projection guidance (GO:1902284)2.25712396
136mitotic metaphase plate congression (GO:0007080)2.24526538
137genitalia morphogenesis (GO:0035112)2.23425991
138asymmetric protein localization (GO:0008105)2.22902749
139chromatin remodeling at centromere (GO:0031055)2.21168927
140negative regulation of chondrocyte differentiation (GO:0032331)2.19464549
141regulation of water loss via skin (GO:0033561)2.18392339
142metaphase plate congression (GO:0051310)2.17449084
143regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.16384938
144regulation of non-canonical Wnt signaling pathway (GO:2000050)2.13761505
145establishment or maintenance of monopolar cell polarity (GO:0061339)2.13680660
146establishment of monopolar cell polarity (GO:0061162)2.13680660
147ventricular cardiac muscle cell development (GO:0055015)2.13310661
148CENP-A containing nucleosome assembly (GO:0034080)2.12522218
149substrate-independent telencephalic tangential migration (GO:0021826)2.12371116
150substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.12371116
151maturation of SSU-rRNA (GO:0030490)2.12147602
152establishment or maintenance of apical/basal cell polarity (GO:0035088)2.11938542
153establishment or maintenance of bipolar cell polarity (GO:0061245)2.11938542
154protein localization to chromosome, centromeric region (GO:0071459)2.10183357
155muscle cell migration (GO:0014812)2.09767828
156camera-type eye morphogenesis (GO:0048593)2.08921106
157gastrulation with mouth forming second (GO:0001702)2.07841901
158cochlea morphogenesis (GO:0090103)2.07726605
159ribosomal small subunit biogenesis (GO:0042274)2.06871242
160protein localization to kinetochore (GO:0034501)2.05146368
161regulation of stem cell maintenance (GO:2000036)2.04834678
162mesodermal cell differentiation (GO:0048333)2.03596651
163cell migration involved in gastrulation (GO:0042074)2.02942217
164body morphogenesis (GO:0010171)2.02642878
165reproductive system development (GO:0061458)2.01884767
166atrial septum morphogenesis (GO:0060413)2.01763158
167NLS-bearing protein import into nucleus (GO:0006607)2.00751519
168plasma membrane repair (GO:0001778)2.00508385
169mitotic sister chromatid segregation (GO:0000070)2.00326479
170lung epithelium development (GO:0060428)2.00199273
171sister chromatid segregation (GO:0000819)1.98614971
172negative regulation of DNA repair (GO:0045738)1.98389913
173chromosome condensation (GO:0030261)1.98269999
174cell migration involved in sprouting angiogenesis (GO:0002042)1.98168358
175lung-associated mesenchyme development (GO:0060484)1.96473644
176regulation of catenin import into nucleus (GO:0035412)1.95967268
177cell-substrate junction assembly (GO:0007044)1.95037207
178pore complex assembly (GO:0046931)1.94291545
179regulation of attachment of spindle microtubules to kinetochore (GO:0051988)1.93996348
180mesenchyme development (GO:0060485)1.93906044
181atrioventricular valve morphogenesis (GO:0003181)1.91905322
182protein localization to microtubule (GO:0035372)1.91387778
183embryonic body morphogenesis (GO:0010172)1.91338982
184mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)1.90290129
185regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.90019631
186mitotic cytokinesis (GO:0000281)1.89789350
187male genitalia development (GO:0030539)1.89699402
188morphogenesis of an epithelial sheet (GO:0002011)1.88923638
189doxorubicin metabolic process (GO:0044598)1.88638344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.95725856
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.69247397
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.62805207
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.45372141
5E2F7_22180533_ChIP-Seq_HELA_Human3.41025926
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.29303218
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.09952630
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.00236265
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.96423366
10* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.31805733
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15344225
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09506628
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89083230
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80334438
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80043965
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78645908
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.74674477
18* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68128069
19ZNF263_19887448_ChIP-Seq_K562_Human1.66051733
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.63161004
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60678661
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60448297
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.59552935
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.56351881
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.55589219
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.53931144
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53144939
28* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50642282
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48566815
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.47274045
31* EP300_21415370_ChIP-Seq_HL-1_Mouse1.46561835
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45066241
33* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.44423136
34CLOCK_20551151_ChIP-Seq_293T_Human1.43949466
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43563466
36ISL1_27105846_Chip-Seq_CPCs_Mouse1.42070114
37* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37621574
38* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36032617
39* FOXA2_19822575_ChIP-Seq_HepG2_Human1.32397838
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.32094555
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31276543
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31276543
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31276543
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30263197
45* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28684229
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26391357
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.25409816
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25328012
49STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25170711
50TCF3_18692474_ChIP-Seq_MESCs_Mouse1.24404467
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.24358312
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.23967069
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22675011
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21398033
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20047781
56CJUN_26792858_Chip-Seq_BT549_Human1.19937348
57* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18881981
58VDR_22108803_ChIP-Seq_LS180_Human1.18805857
59AR_21909140_ChIP-Seq_LNCAP_Human1.16909452
60* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16044261
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15486145
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15241421
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14249701
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13557646
65* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13381113
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12487603
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12487603
68* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.12070600
69AHR_22903824_ChIP-Seq_MCF-7_Human1.11720973
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10502951
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10215760
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08176507
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06007568
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05149821
75SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04607145
76EZH2_22144423_ChIP-Seq_EOC_Human1.04600123
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.03429544
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03160470
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.01621515
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01591930
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.01550429
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01507067
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00960116
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00542309
85* GATA4_25053715_ChIP-Seq_YYC3_Human1.00520051
86TP53_16413492_ChIP-PET_HCT116_Human1.00116254
87BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99168531
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.98960297
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98614446
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98614446
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.98010162
92RING1B_27294783_Chip-Seq_NPCs_Mouse0.96994511
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96285239
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95695473
95WT1_19549856_ChIP-ChIP_CCG9911_Human0.95225669
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94985877
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94802574
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94707906
99* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94380234
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.94145552
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93265233
102RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93231806
103* TP63_23658742_ChIP-Seq_EP156T_Human0.92940809
104* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92385364
105TP63_19390658_ChIP-ChIP_HaCaT_Human0.91795830
106CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91052817
107* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90178225
108FUS_26573619_Chip-Seq_HEK293_Human0.89989872
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89599168
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89565278
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88915109
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.88749200
113RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88374932
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88370447
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87508638
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87282737
117HTT_18923047_ChIP-ChIP_STHdh_Human0.87182186
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87009178
119SOX9_26525672_Chip-Seq_HEART_Mouse0.86918556
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86764344
121TP53_20018659_ChIP-ChIP_R1E_Mouse0.86374238
122TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85792408
123* GATA6_25053715_ChIP-Seq_YYC3_Human0.85301784
124* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84982039
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84861164
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.84652273
127MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84358939
128TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.84317893
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84290738
130EZH2_27304074_Chip-Seq_ESCs_Mouse0.84181593
131* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84090375
132TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83715113
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83542939
134RNF2_27304074_Chip-Seq_NSC_Mouse0.83423974
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83401077
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.83305239
137* BCAT_22108803_ChIP-Seq_LS180_Human0.83121180
138* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82618279
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.82442720
140RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82289091
141EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82289091
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81852969
143AR_21572438_ChIP-Seq_LNCaP_Human0.81641412
144* SOX2_20726797_ChIP-Seq_SW620_Human0.81577198
145* HNF4A_19822575_ChIP-Seq_HepG2_Human0.81366442
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80713642
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80102072
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79630140
149TP53_18474530_ChIP-ChIP_U2OS_Human0.79589037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.16326942
2MP0005360_urolithiasis3.65715684
3MP0005085_abnormal_gallbladder_physiolo3.41700178
4MP0005365_abnormal_bile_salt3.20845217
5MP0005451_abnormal_body_composition2.91935836
6MP0008875_abnormal_xenobiotic_pharmacok2.55721693
7MP0010030_abnormal_orbit_morphology2.50202920
8MP0000566_synostosis2.49426042
9MP0006292_abnormal_olfactory_placode2.46272021
10MP0009379_abnormal_foot_pigmentation2.16449259
11MP0003252_abnormal_bile_duct2.15788274
12MP0003806_abnormal_nucleotide_metabolis2.09636987
13MP0000579_abnormal_nail_morphology2.08302173
14MP0002796_impaired_skin_barrier2.02912000
15MP0009053_abnormal_anal_canal1.94933793
16MP0010234_abnormal_vibrissa_follicle1.94372398
17MP0002249_abnormal_larynx_morphology1.94139329
18MP0003705_abnormal_hypodermis_morpholog1.93962440
19MP0003937_abnormal_limbs/digits/tail_de1.89811697
20MP0009384_cardiac_valve_regurgitation1.79956902
21MP0001293_anophthalmia1.79648410
22MP0003941_abnormal_skin_development1.78311698
23MP0010678_abnormal_skin_adnexa1.73544608
24MP0005275_abnormal_skin_tensile1.63303694
25MP0000762_abnormal_tongue_morphology1.59720409
26MP0000462_abnormal_digestive_system1.56961592
27MP0001346_abnormal_lacrimal_gland1.53592139
28MP0005248_abnormal_Harderian_gland1.51717991
29MP0003566_abnormal_cell_adhesion1.51652665
30MP0004272_abnormal_basement_membrane1.51420683
31MP0000537_abnormal_urethra_morphology1.49201255
32MP0002233_abnormal_nose_morphology1.47263170
33MP0000383_abnormal_hair_follicle1.46984719
34MP0005408_hypopigmentation1.46685105
35MP0003195_calcinosis1.44076140
36MP0009250_abnormal_appendicular_skeleto1.43369557
37MP0010329_abnormal_lipoprotein_level1.42995233
38MP0002098_abnormal_vibrissa_morphology1.39739688
39MP0003755_abnormal_palate_morphology1.38696976
40MP0003136_yellow_coat_color1.38566787
41MP0003718_maternal_effect1.38527742
42MP0000647_abnormal_sebaceous_gland1.35180650
43MP0001666_abnormal_nutrient_absorption1.33446052
44MP0002060_abnormal_skin_morphology1.33394733
45MP0004957_abnormal_blastocyst_morpholog1.33247561
46MP0003385_abnormal_body_wall1.31233581
47MP0002084_abnormal_developmental_patter1.30512149
48MP0010352_gastrointestinal_tract_polyps1.30487022
49MP0009780_abnormal_chondrocyte_physiolo1.29791534
50MP0008932_abnormal_embryonic_tissue1.29364733
51MP0003693_abnormal_embryo_hatching1.29170134
52MP0002102_abnormal_ear_morphology1.28829433
53MP0003122_maternal_imprinting1.26534729
54MP0002085_abnormal_embryonic_tissue1.24011428
55MP0005332_abnormal_amino_acid1.22247432
56MP0000751_myopathy1.21436613
57MP0004264_abnormal_extraembryonic_tissu1.21266675
58MP0003950_abnormal_plasma_membrane1.21033056
59MP0004185_abnormal_adipocyte_glucose1.18956071
60MP0005083_abnormal_biliary_tract1.17077511
61MP0010368_abnormal_lymphatic_system1.14500369
62MP0009840_abnormal_foam_cell1.14335056
63MP0005187_abnormal_penis_morphology1.13798027
64MP0003942_abnormal_urinary_system1.12953505
65MP0005409_darkened_coat_color1.09347697
66MP0003890_abnormal_embryonic-extraembry1.07953492
67MP0008789_abnormal_olfactory_epithelium1.05231751
68MP0000733_abnormal_muscle_development1.05012099
69MP0002089_abnormal_postnatal_growth/wei1.04381990
70MP0000534_abnormal_ureter_morphology1.02485775
71MP0002254_reproductive_system_inflammat1.01984952
72MP0001340_abnormal_eyelid_morphology1.00985837
73MP0003123_paternal_imprinting1.00094319
74MP0003453_abnormal_keratinocyte_physiol0.99989658
75MP0005623_abnormal_meninges_morphology0.99843831
76MP0000467_abnormal_esophagus_morphology0.99320950
77MP0002697_abnormal_eye_size0.98692460
78MP0003119_abnormal_digestive_system0.98296164
79MP0005395_other_phenotype0.97680622
80MP0001730_embryonic_growth_arrest0.97671478
81MP0004381_abnormal_hair_follicle0.96508439
82* MP0003861_abnormal_nervous_system0.96412076
83MP0005257_abnormal_intraocular_pressure0.95752079
84MP0003935_abnormal_craniofacial_develop0.95656844
85MP0008438_abnormal_cutaneous_collagen0.95458767
86MP0003077_abnormal_cell_cycle0.94878055
87MP0005508_abnormal_skeleton_morphology0.94572959
88MP0000049_abnormal_middle_ear0.94505785
89MP0000432_abnormal_head_morphology0.94497615
90MP0005501_abnormal_skin_physiology0.93716073
91* MP0001672_abnormal_embryogenesis/_devel0.93693877
92* MP0005380_embryogenesis_phenotype0.93693877
93MP0001661_extended_life_span0.93250613
94MP0000427_abnormal_hair_cycle0.92951405
95MP0001697_abnormal_embryo_size0.92877971
96MP0000778_abnormal_nervous_system0.92324753
97MP0001849_ear_inflammation0.92120688
98MP0002932_abnormal_joint_morphology0.91665403
99MP0009703_decreased_birth_body0.90113686
100MP0002282_abnormal_trachea_morphology0.90016636
101MP0000749_muscle_degeneration0.89726015
102MP0000377_abnormal_hair_follicle0.88848263
103MP0002938_white_spotting0.88600088
104* MP0003984_embryonic_growth_retardation0.87322234
105MP0002116_abnormal_craniofacial_bone0.86753343
106MP0001286_abnormal_eye_development0.86197299
107MP0004197_abnormal_fetal_growth/weight/0.85830910
108MP0002108_abnormal_muscle_morphology0.85758112
109MP0004019_abnormal_vitamin_homeostasis0.85502939
110MP0005076_abnormal_cell_differentiation0.84572279
111MP0004087_abnormal_muscle_fiber0.83950091
112MP0002118_abnormal_lipid_homeostasis0.83780247
113* MP0002088_abnormal_embryonic_growth/wei0.83528317
114MP0003315_abnormal_perineum_morphology0.83481954
115* MP0002111_abnormal_tail_morphology0.83009464
116MP0009697_abnormal_copulation0.82502153
117MP0005023_abnormal_wound_healing0.81500134
118MP0004084_abnormal_cardiac_muscle0.80154718
119MP0006138_congestive_heart_failure0.79742527
120MP0003115_abnormal_respiratory_system0.79146001
121MP0001299_abnormal_eye_distance/0.78896884
122MP0004133_heterotaxia0.78556536
123MP0003938_abnormal_ear_development0.78372505
124MP0003111_abnormal_nucleus_morphology0.77465422
125MP0002092_abnormal_eye_morphology0.75775223
126MP0002295_abnormal_pulmonary_circulatio0.75209205
127MP0001216_abnormal_epidermal_layer0.74276247
128MP0000163_abnormal_cartilage_morphology0.74210598
129MP0000428_abnormal_craniofacial_morphol0.73241241
130MP0009672_abnormal_birth_weight0.73149050
131MP0002177_abnormal_outer_ear0.72143168
132MP0002653_abnormal_ependyma_morphology0.72021262
133MP0000613_abnormal_salivary_gland0.71537704
134MP0005394_taste/olfaction_phenotype0.70808520
135MP0005499_abnormal_olfactory_system0.70808520
136MP0003868_abnormal_feces_composition0.70106691
137MP0002234_abnormal_pharynx_morphology0.68760288
138MP0005220_abnormal_exocrine_pancreas0.68633354
139MP0005647_abnormal_sex_gland0.67482717
140MP0005503_abnormal_tendon_morphology0.67231052
141MP0002896_abnormal_bone_mineralization0.66322152
142MP0010771_integument_phenotype0.65538093

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.00065186
2Deep venous thrombosis (HP:0002625)4.49929401
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.68626134
4Xanthomatosis (HP:0000991)3.57206707
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.49793002
6Hypobetalipoproteinemia (HP:0003563)3.21798886
7Prolonged partial thromboplastin time (HP:0003645)2.97815659
8Hypoalphalipoproteinemia (HP:0003233)2.91575976
9Hypolipoproteinemia (HP:0010981)2.88238077
10Epidermoid cyst (HP:0200040)2.87163540
11Hyperlipoproteinemia (HP:0010980)2.83048194
12Hyperglycinemia (HP:0002154)2.78254118
13Right ventricular cardiomyopathy (HP:0011663)2.74154766
14Abnormality of methionine metabolism (HP:0010901)2.65700392
15Hypoglycemic coma (HP:0001325)2.64338955
16Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56649703
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.55300516
18Abnormality of glycine metabolism (HP:0010895)2.49271108
19Abnormality of serine family amino acid metabolism (HP:0010894)2.49271108
20Ketosis (HP:0001946)2.43093301
21Coronal craniosynostosis (HP:0004440)2.43053387
22Missing ribs (HP:0000921)2.43012044
23Fat malabsorption (HP:0002630)2.41964379
24Abnormality of sulfur amino acid metabolism (HP:0004339)2.41523428
25Hyperglycinuria (HP:0003108)2.38971582
26Hyperglycemia (HP:0003074)2.37898290
27Turricephaly (HP:0000262)2.34056856
28Hyperammonemia (HP:0001987)2.33553461
29Hypoplastic labia majora (HP:0000059)2.29975309
30Aplasia involving bones of the upper limbs (HP:0009823)2.28954602
31Aplasia of the phalanges of the hand (HP:0009802)2.28954602
32Aplasia involving bones of the extremities (HP:0009825)2.28954602
33Complement deficiency (HP:0004431)2.27581879
34Pterygium (HP:0001059)2.25105218
35Conjugated hyperbilirubinemia (HP:0002908)2.21622628
36Abnormality of the labia majora (HP:0012881)2.17561701
37Abnormality of the nasal septum (HP:0000419)2.16474623
38Reticulocytopenia (HP:0001896)2.15976913
39Adrenal hypoplasia (HP:0000835)2.14192713
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11984380
41Lip pit (HP:0100267)2.09702071
42Hypophosphatemic rickets (HP:0004912)2.09595887
43Neonatal short-limb short stature (HP:0008921)2.07406886
44Bifid scrotum (HP:0000048)2.04723906
45Abnormality of the common coagulation pathway (HP:0010990)2.04446481
46Bifid tongue (HP:0010297)1.98578399
47Cutaneous finger syndactyly (HP:0010554)1.95932083
48Hypochromic microcytic anemia (HP:0004840)1.95875305
49Ketoacidosis (HP:0001993)1.94713014
5011 pairs of ribs (HP:0000878)1.94425693
51Partial duplication of thumb phalanx (HP:0009944)1.93078162
52Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91958893
53Vertebral arch anomaly (HP:0008438)1.90421385
54Enlarged kidneys (HP:0000105)1.89669136
55Chromsome breakage (HP:0040012)1.87327459
56Cutaneous syndactyly (HP:0012725)1.86500696
57Hepatocellular carcinoma (HP:0001402)1.86234072
58Hypoglycemic seizures (HP:0002173)1.86093019
59Duplication of thumb phalanx (HP:0009942)1.85046499
60Papillary thyroid carcinoma (HP:0002895)1.84493880
61Hyperinsulinemic hypoglycemia (HP:0000825)1.82366214
62Limited hip movement (HP:0008800)1.81802355
63Parakeratosis (HP:0001036)1.81575585
64Abnormal number of incisors (HP:0011064)1.81554774
65Increased nuchal translucency (HP:0010880)1.80735439
66Popliteal pterygium (HP:0009756)1.80588121
67Hypoplastic ischia (HP:0003175)1.80245930
68Shawl scrotum (HP:0000049)1.79648229
69Malnutrition (HP:0004395)1.79343194
70Nemaline bodies (HP:0003798)1.79217080
71Short hallux (HP:0010109)1.79121825
72Rickets (HP:0002748)1.77880815
73Premature rupture of membranes (HP:0001788)1.77864141
74Fused cervical vertebrae (HP:0002949)1.77816841
75Preaxial foot polydactyly (HP:0001841)1.77609774
76Shallow orbits (HP:0000586)1.77236783
77Protrusio acetabuli (HP:0003179)1.76801499
78High anterior hairline (HP:0009890)1.75718308
79Abnormality of the ischium (HP:0003174)1.75683743
80Partial duplication of the phalanx of hand (HP:0009999)1.75153653
81Bronchomalacia (HP:0002780)1.74120177
82Facial cleft (HP:0002006)1.73169973
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.72883019
84Abnormality of the intrinsic pathway (HP:0010989)1.71949919
85Hyporeflexia of lower limbs (HP:0002600)1.71823278
86Muscle fiber inclusion bodies (HP:0100299)1.70557226
87Hypercholesterolemia (HP:0003124)1.70474967
88Abnormality of the calcaneus (HP:0008364)1.69214050
89Hepatoblastoma (HP:0002884)1.69112778
90Anophthalmia (HP:0000528)1.67790592
91Chorioretinal atrophy (HP:0000533)1.67302984
92Vertebral clefting (HP:0008428)1.66844427
93Ulnar bowing (HP:0003031)1.65948495
94Arterial tortuosity (HP:0005116)1.63825115
95Maternal diabetes (HP:0009800)1.61688005
96Synostosis of carpal bones (HP:0005048)1.61379343
97Steatorrhea (HP:0002570)1.61296165
98Natal tooth (HP:0000695)1.61034053
99Midline defect of the nose (HP:0004122)1.60877323
100Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.58860818
101Vertebral hypoplasia (HP:0008417)1.58860818
102Abnormality of the middle phalanges of the toes (HP:0010183)1.58728180
103Microglossia (HP:0000171)1.58379775
104Advanced eruption of teeth (HP:0006288)1.58102516
105Humeroradial synostosis (HP:0003041)1.57314875
106Synostosis involving the elbow (HP:0003938)1.57314875
107Alopecia of scalp (HP:0002293)1.55674307
108Abnormal cartilage morphology (HP:0002763)1.55169328
109Ectopic kidney (HP:0000086)1.55079914
110Abnormal lung lobation (HP:0002101)1.54774038
111Delayed CNS myelination (HP:0002188)1.54677964
112Rib fusion (HP:0000902)1.54615413
113Abnormality of the phalanges of the 2nd finger (HP:0009541)1.54213745
114Tarsal synostosis (HP:0008368)1.53943437
115Skin nodule (HP:0200036)1.53673978
116Type 1 muscle fiber predominance (HP:0003803)1.52757086
117Atrophic scars (HP:0001075)1.52734615
118Wide anterior fontanel (HP:0000260)1.52575168
119Vascular calcification (HP:0004934)1.51947150
120Abnormality of serum amino acid levels (HP:0003112)1.51858516
121Cardiovascular calcification (HP:0011915)1.51453247
122Ectopic anus (HP:0004397)1.51174608
123Capillary hemangiomas (HP:0005306)1.50426539
124Deviation of the thumb (HP:0009603)1.50359122
125Septo-optic dysplasia (HP:0100842)1.49598893
126Infantile muscular hypotonia (HP:0008947)1.49328985
127Synostosis involving bones of the lower limbs (HP:0009138)1.49152749
128Synostosis involving bones of the feet (HP:0009140)1.49152749
129Absent radius (HP:0003974)1.49082929
130Fragile nails (HP:0001808)1.48818466
131Aplasia/Hypoplasia of the hallux (HP:0008362)1.48471911
132Abnormality of the lacrimal duct (HP:0011481)1.48451036
133Back pain (HP:0003418)1.48424407
134Esophageal atresia (HP:0002032)1.47918569
135Myocardial infarction (HP:0001658)1.47821959
136Amniotic constriction ring (HP:0009775)1.47511683
137Abnormality of placental membranes (HP:0011409)1.47511683
138Pseudobulbar signs (HP:0002200)1.46091508
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.46049432
140Vitreoretinal degeneration (HP:0000655)1.45896136
141Labial hypoplasia (HP:0000066)1.45581406
142Focal segmental glomerulosclerosis (HP:0000097)1.45323499
143Hypotrichosis (HP:0001006)1.45022321
144Median cleft lip (HP:0000161)1.44937590
145Taurodontia (HP:0000679)1.44783878
146Abnormality of permanent molar morphology (HP:0011071)1.44783878
147Abnormality of the dental root (HP:0006486)1.44783878
148Broad metatarsal (HP:0001783)1.44555399
149Abnormality of the 2nd finger (HP:0004100)1.44420875
150Cupped ear (HP:0000378)1.43331145
151Hypoplastic female external genitalia (HP:0012815)1.43266552
152Abnormality of the distal phalanx of the thumb (HP:0009617)1.43150494
153Bicornuate uterus (HP:0000813)1.42318698
154Ankyloglossia (HP:0010296)1.41462549
155Nephroblastoma (Wilms tumor) (HP:0002667)1.41250292
156Renal duplication (HP:0000075)1.40734305
157Selective tooth agenesis (HP:0001592)1.40441323
158Osteomalacia (HP:0002749)1.39486976
159Abnormality of the aortic arch (HP:0012303)1.39404522
160Vascular tortuosity (HP:0004948)1.38839224
161Hip contracture (HP:0003273)1.38762646
162Proximal placement of thumb (HP:0009623)1.37806798
163Calcaneovalgus deformity (HP:0001848)1.37649468
164Abnormality of the salivary glands (HP:0010286)1.37093832
165Absent eyelashes (HP:0000561)1.35587449
166Long clavicles (HP:0000890)1.35186878
167Abnormality of the nasolacrimal system (HP:0000614)1.34770404
168Aplasia involving forearm bones (HP:0009822)1.34657991
169Absent forearm bone (HP:0003953)1.34657991
170Myelomeningocele (HP:0002475)1.34525779
171Abnormality of molar morphology (HP:0011070)1.34321345
172Abnormality of molar (HP:0011077)1.34321345
173Atresia of the external auditory canal (HP:0000413)1.33965018
174Volvulus (HP:0002580)1.33436009
175Aplasia/Hypoplasia of the sternum (HP:0006714)1.33142433
176Heterotopia (HP:0002282)1.31944930
177Tibial bowing (HP:0002982)1.31188343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.06452727
2STK38L3.22083851
3LATS23.21530523
4ERBB43.16674577
5MET2.20681533
6STK392.05017258
7EPHA21.99595903
8EPHB21.97454993
9CDC71.80959664
10SIK11.68302565
11NUAK11.68223569
12FGFR21.66420755
13STK31.61418988
14LMTK21.60788593
15TTK1.56755170
16STK241.56049488
17DDR21.55712487
18MAPKAPK31.53770760
19INSRR1.49607585
20MST1R1.49077765
21PLK41.43569268
22PAK31.39943597
23MAP3K91.39083853
24EEF2K1.38702515
25ICK1.32422918
26AKT31.28761358
27BCR1.25043086
28WEE11.22783713
29TRPM71.21719604
30NEK21.20184913
31MAP3K101.18305166
32BRSK21.16267724
33FER1.15808113
34NEK11.15114624
35BUB11.14866191
36FRK1.11026396
37NTRK11.09876002
38PDGFRA1.08777801
39MAPK151.08586928
40RPS6KB21.07860545
41MELK1.07730246
42BCKDK1.07388440
43PLK11.07274127
44DMPK1.05259402
45PTK21.03862066
46MAP3K31.03191830
47TNIK1.02935699
48SRPK11.01822937
49PRKD31.00539162
50* AURKB0.97197335
51MAPKAPK50.94674188
52TAOK10.94321142
53OBSCN0.94200633
54CAMK1G0.94047104
55PRKAA20.91838647
56OXSR10.91811670
57BRAF0.90404326
58MYLK0.89827443
59DYRK20.89580850
60MST40.88976811
61MUSK0.88971836
62RIPK10.88317076
63CDK80.87496037
64MAP3K60.87230957
65CSNK1G10.85662542
66ERBB20.84438816
67KSR20.84135292
68WNK40.81231049
69MTOR0.81037027
70PHKG10.80231125
71PHKG20.80231125
72BRSK10.79892178
73PIK3CA0.77301357
74MKNK20.76475505
75PLK30.75891718
76CSNK1A1L0.75191631
77PKN10.75127235
78TAOK30.74807196
79CHEK10.74503023
80EIF2AK10.74397080
81CAMK1D0.73653813
82CDK120.73642698
83CASK0.73438981
84PBK0.70958841
85* AURKA0.70932648
86MAP3K20.70508755
87PAK40.70291519
88TYRO30.70232438
89STK160.69792747
90FGFR10.68945470
91PTK60.68650606
92TTN0.68276035
93PNCK0.67233947
94CDK70.66853397
95ILK0.64021160
96MAP2K20.63823980
97PRKAA10.63385526
98PRKCI0.63360271
99GSK3A0.61737323
100SGK4940.61596762
101SGK2230.61596762
102MOS0.61011862
103MKNK10.60508443
104ABL20.58820865
105PRKD20.58464416
106EPHB10.58320295
107PRKD10.58209001
108CDK90.57411986
109ARAF0.57347427
110CSNK1G30.56404993
111MAPK110.56108044
112MAP2K10.56064950
113TGFBR10.55595899
114FGFR40.55500086
115MAP3K70.53910924
116CSNK1E0.53807929
117NME10.53788658
118TSSK60.52161222
119CSNK1D0.51157349
120AKT20.51105102
121* CDK10.51064509
122PDGFRB0.50803760
123PAK20.50786464
124ATM0.50326148
125BMX0.49472466
126CAMK2G0.48976282
127TAF10.48527475
128EPHA40.47442609
129TRIM280.47420622
130MAPK130.46951155
131CSNK1G20.46608607
132EPHA30.45905183
133PAK60.45791461
134STK380.45245177
135PKN20.44877424
136ZAK0.44605040
137MAP3K40.44532430
138CDK60.44332933
139SGK30.43823651
140MAP2K70.42817789
141STK40.42295411
142BMPR1B0.41596379
143PINK10.41558147
144TRIB30.40962438
145CHEK20.39778308
146CDK20.39047479
147CDK30.38632408
148CAMK2A0.38163152
149SMG10.37528672
150PRKDC0.37474374
151CAMK2D0.37351939
152MAPK140.36163658
153MAP3K80.35515908
154ROCK20.35303388
155KSR10.34790432
156PRKCE0.33879718

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.41014201
2Nitrogen metabolism_Homo sapiens_hsa009103.22010913
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90680263
4Butanoate metabolism_Homo sapiens_hsa006502.36058775
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.31290725
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30017671
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26014114
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22971553
9Arginine biosynthesis_Homo sapiens_hsa002202.21343470
10Tryptophan metabolism_Homo sapiens_hsa003802.19716465
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15149470
12Histidine metabolism_Homo sapiens_hsa003402.14569469
13Fatty acid degradation_Homo sapiens_hsa000712.12703547
14Steroid biosynthesis_Homo sapiens_hsa001002.08661808
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01369550
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00179880
17Sulfur metabolism_Homo sapiens_hsa009201.96165717
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.87514215
19Chemical carcinogenesis_Homo sapiens_hsa052041.86874116
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.85514069
21Complement and coagulation cascades_Homo sapiens_hsa046101.83746450
22Retinol metabolism_Homo sapiens_hsa008301.78479695
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78215729
24Fatty acid elongation_Homo sapiens_hsa000621.72702980
25Mismatch repair_Homo sapiens_hsa034301.71487902
26Propanoate metabolism_Homo sapiens_hsa006401.71219053
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70186215
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67129821
29Fatty acid metabolism_Homo sapiens_hsa012121.65756407
30PPAR signaling pathway_Homo sapiens_hsa033201.52398784
31beta-Alanine metabolism_Homo sapiens_hsa004101.51051274
32Peroxisome_Homo sapiens_hsa041461.51003609
33Ribosome_Homo sapiens_hsa030101.49376914
34Tyrosine metabolism_Homo sapiens_hsa003501.48526776
35Cell cycle_Homo sapiens_hsa041101.42503813
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41915079
37Phenylalanine metabolism_Homo sapiens_hsa003601.38011436
38DNA replication_Homo sapiens_hsa030301.37285106
39Thyroid cancer_Homo sapiens_hsa052161.30878067
40Linoleic acid metabolism_Homo sapiens_hsa005911.27802265
41Arginine and proline metabolism_Homo sapiens_hsa003301.26335405
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25874645
43Selenocompound metabolism_Homo sapiens_hsa004501.25835870
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25169929
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23751184
46Bile secretion_Homo sapiens_hsa049761.19376847
47Fat digestion and absorption_Homo sapiens_hsa049751.18694796
48Vitamin B6 metabolism_Homo sapiens_hsa007501.18052052
49Basal cell carcinoma_Homo sapiens_hsa052171.16763294
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13421362
51Lysine degradation_Homo sapiens_hsa003101.12718944
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.08040733
53Non-homologous end-joining_Homo sapiens_hsa034501.07658485
54Nucleotide excision repair_Homo sapiens_hsa034201.07513771
55Starch and sucrose metabolism_Homo sapiens_hsa005001.07285556
56RNA transport_Homo sapiens_hsa030131.03380340
57Pyruvate metabolism_Homo sapiens_hsa006201.02533101
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.00860510
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00540373
60Vitamin digestion and absorption_Homo sapiens_hsa049771.00510922
61Glutathione metabolism_Homo sapiens_hsa004801.00239962
62Hedgehog signaling pathway_Homo sapiens_hsa043401.00151425
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99501171
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97688713
65Ovarian steroidogenesis_Homo sapiens_hsa049130.94764175
66Folate biosynthesis_Homo sapiens_hsa007900.93628620
67ABC transporters_Homo sapiens_hsa020100.91514289
68TGF-beta signaling pathway_Homo sapiens_hsa043500.90518629
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87495440
70* Hippo signaling pathway_Homo sapiens_hsa043900.87436080
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.84553716
72Notch signaling pathway_Homo sapiens_hsa043300.84257265
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.83963886
74Basal transcription factors_Homo sapiens_hsa030220.83552382
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82274124
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81427932
77mRNA surveillance pathway_Homo sapiens_hsa030150.80312211
78ECM-receptor interaction_Homo sapiens_hsa045120.80036466
79Ether lipid metabolism_Homo sapiens_hsa005650.79779967
80* Tight junction_Homo sapiens_hsa045300.78820725
81Fanconi anemia pathway_Homo sapiens_hsa034600.78644244
82Biosynthesis of amino acids_Homo sapiens_hsa012300.78491299
83Caffeine metabolism_Homo sapiens_hsa002320.77502801
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75934567
85Fatty acid biosynthesis_Homo sapiens_hsa000610.75851007
86Galactose metabolism_Homo sapiens_hsa000520.75172191
87p53 signaling pathway_Homo sapiens_hsa041150.74089503
88Pathways in cancer_Homo sapiens_hsa052000.71716934
89Endometrial cancer_Homo sapiens_hsa052130.68186512
90Homologous recombination_Homo sapiens_hsa034400.67358663
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66550270
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65730105
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65644283
94Alcoholism_Homo sapiens_hsa050340.65163327
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64530843
96* Adherens junction_Homo sapiens_hsa045200.63849767
97Carbon metabolism_Homo sapiens_hsa012000.62181146
98Spliceosome_Homo sapiens_hsa030400.62032362
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60392053
100Colorectal cancer_Homo sapiens_hsa052100.58554942
101Gap junction_Homo sapiens_hsa045400.58326087
102One carbon pool by folate_Homo sapiens_hsa006700.57481548
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57074612
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56915800
105Sulfur relay system_Homo sapiens_hsa041220.55582375
106Glycerolipid metabolism_Homo sapiens_hsa005610.54811777
107Insulin signaling pathway_Homo sapiens_hsa049100.52211501
108Oocyte meiosis_Homo sapiens_hsa041140.51232143
109Base excision repair_Homo sapiens_hsa034100.50359728
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50121794
111Cardiac muscle contraction_Homo sapiens_hsa042600.49975884
112ErbB signaling pathway_Homo sapiens_hsa040120.49554579
113Pentose phosphate pathway_Homo sapiens_hsa000300.49317560
114Thyroid hormone synthesis_Homo sapiens_hsa049180.48930271
115Protein digestion and absorption_Homo sapiens_hsa049740.47988783
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47841507
117Circadian rhythm_Homo sapiens_hsa047100.46520358
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44452764
119Bladder cancer_Homo sapiens_hsa052190.42703476
120Arachidonic acid metabolism_Homo sapiens_hsa005900.41004057
121MicroRNAs in cancer_Homo sapiens_hsa052060.38869266
122Metabolic pathways_Homo sapiens_hsa011000.37066523
123Prostate cancer_Homo sapiens_hsa052150.35838093
124AMPK signaling pathway_Homo sapiens_hsa041520.32927355
125Wnt signaling pathway_Homo sapiens_hsa043100.32668235
126Staphylococcus aureus infection_Homo sapiens_hsa051500.31158824
127Axon guidance_Homo sapiens_hsa043600.30482154
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30357244
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.30337709
130Focal adhesion_Homo sapiens_hsa045100.30110860
131Insulin resistance_Homo sapiens_hsa049310.26775682
132Dorso-ventral axis formation_Homo sapiens_hsa043200.26332760
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26182546
134Sphingolipid metabolism_Homo sapiens_hsa006000.25548456
135Proteoglycans in cancer_Homo sapiens_hsa052050.24597208
136Prion diseases_Homo sapiens_hsa050200.23727194
137Melanogenesis_Homo sapiens_hsa049160.21811283
138Small cell lung cancer_Homo sapiens_hsa052220.21418689
139Dilated cardiomyopathy_Homo sapiens_hsa054140.21091399
140Melanoma_Homo sapiens_hsa052180.19542543
141Renal cell carcinoma_Homo sapiens_hsa052110.17307345

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