PARD6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.28941288
2chaperone-mediated protein transport (GO:0072321)4.63887669
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.61524268
4synaptic vesicle exocytosis (GO:0016079)4.45761156
5protein localization to synapse (GO:0035418)4.39784130
6ATP synthesis coupled proton transport (GO:0015986)4.35312057
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.35312057
8dendritic spine morphogenesis (GO:0060997)4.31660923
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.20597678
10neuronal ion channel clustering (GO:0045161)4.04379740
11vocalization behavior (GO:0071625)4.01135508
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.86909886
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.86705867
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.85903146
15presynaptic membrane assembly (GO:0097105)3.79942278
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.79865479
17neuronal action potential propagation (GO:0019227)3.69691929
18establishment of mitochondrion localization (GO:0051654)3.69640446
19regulation of synaptic vesicle exocytosis (GO:2000300)3.68624118
20protein complex biogenesis (GO:0070271)3.66624565
21central nervous system myelination (GO:0022010)3.66592595
22axon ensheathment in central nervous system (GO:0032291)3.66592595
23dendritic spine organization (GO:0097061)3.58792700
24negative regulation of microtubule polymerization (GO:0031115)3.54858184
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.51984340
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49566246
27postsynaptic membrane organization (GO:0001941)3.49417682
28presynaptic membrane organization (GO:0097090)3.47610195
29regulation of neuronal synaptic plasticity (GO:0048168)3.47495185
30substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.43135008
31substrate-independent telencephalic tangential migration (GO:0021826)3.43135008
32mitochondrial respiratory chain complex assembly (GO:0033108)3.40183567
33energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.37121875
34ATP hydrolysis coupled proton transport (GO:0015991)3.37121875
35negative regulation of appetite (GO:0032099)3.35618450
36negative regulation of response to food (GO:0032096)3.35618450
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35507862
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.35507862
39NADH dehydrogenase complex assembly (GO:0010257)3.35507862
40respiratory electron transport chain (GO:0022904)3.33686197
41electron transport chain (GO:0022900)3.29368253
42positive regulation of dendritic spine development (GO:0060999)3.25489279
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25165566
44protein polyglutamylation (GO:0018095)3.24438468
45GTP biosynthetic process (GO:0006183)3.23717860
46mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.23290752
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22624110
48synaptic transmission, glutamatergic (GO:0035249)3.21620854
49response to pheromone (GO:0019236)3.19876826
50regulation of synaptic vesicle transport (GO:1902803)3.19382359
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.17942321
52neuron-neuron synaptic transmission (GO:0007270)3.17306556
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.16719733
54neuromuscular synaptic transmission (GO:0007274)3.16451136
55cerebellar Purkinje cell layer development (GO:0021680)3.15214651
56glutamate secretion (GO:0014047)3.13987106
57establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.09323772
58mitochondrion transport along microtubule (GO:0047497)3.09323772
59guanosine-containing compound biosynthetic process (GO:1901070)3.07646333
60regulation of glutamate receptor signaling pathway (GO:1900449)3.07542700
61regulation of postsynaptic membrane potential (GO:0060078)3.07111017
62long-term memory (GO:0007616)3.06772511
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.06158730
64long-term synaptic potentiation (GO:0060291)3.04129283
65neurotransmitter secretion (GO:0007269)3.03720630
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03562294
67ionotropic glutamate receptor signaling pathway (GO:0035235)3.02212283
68regulation of neurotransmitter levels (GO:0001505)3.01316962
69positive regulation of synapse assembly (GO:0051965)3.00500674
70regulation of synapse maturation (GO:0090128)3.00256225
71cellular potassium ion homeostasis (GO:0030007)3.00174016
72cullin deneddylation (GO:0010388)2.99430636
73positive regulation of membrane potential (GO:0045838)2.98137639
74behavioral response to nicotine (GO:0035095)2.98106260
75glutamate receptor signaling pathway (GO:0007215)2.97645398
76positive regulation of synapse maturation (GO:0090129)2.94897115
77protein-cofactor linkage (GO:0018065)2.90168610
78sperm motility (GO:0030317)2.89506098
79transmission of nerve impulse (GO:0019226)2.89148115
80positive regulation of amino acid transport (GO:0051957)2.87375822
81purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.84261074
82transferrin transport (GO:0033572)2.84228006
83protein deneddylation (GO:0000338)2.81964353
84auditory behavior (GO:0031223)2.81496427
85positive regulation of neurotransmitter secretion (GO:0001956)2.81056542
86positive regulation of dendritic spine morphogenesis (GO:0061003)2.80883969
87acrosome reaction (GO:0007340)2.79683756
88UTP biosynthetic process (GO:0006228)2.78928654
89adult walking behavior (GO:0007628)2.78733835
90regulation of response to food (GO:0032095)2.77901554
91regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.77341838
92regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.77341838
93establishment of synaptic vesicle localization (GO:0097480)2.76576319
94synaptic vesicle transport (GO:0048489)2.76576319
95protein localization to cilium (GO:0061512)2.76571636
96exploration behavior (GO:0035640)2.76287720
97regulation of dendritic spine morphogenesis (GO:0061001)2.75849194
98layer formation in cerebral cortex (GO:0021819)2.75631654
99regulation of long-term neuronal synaptic plasticity (GO:0048169)2.75455151
100purine nucleoside triphosphate biosynthetic process (GO:0009145)2.75276556
101regulation of neurotransmitter transport (GO:0051588)2.75037674
102neuromuscular process controlling balance (GO:0050885)2.74712560
103cerebral cortex neuron differentiation (GO:0021895)2.73377341
104ATP biosynthetic process (GO:0006754)2.72987707
105regulation of voltage-gated calcium channel activity (GO:1901385)2.72747671
106regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.72597075
107serotonin metabolic process (GO:0042428)2.71477898
108adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.71444313
109detection of calcium ion (GO:0005513)2.71405214
110neurotransmitter-gated ion channel clustering (GO:0072578)2.70598868
111regulation of synaptic plasticity (GO:0048167)2.69668343
112hydrogen ion transmembrane transport (GO:1902600)2.68921628
113axonal fasciculation (GO:0007413)2.68098770
114inner mitochondrial membrane organization (GO:0007007)2.68087186
115startle response (GO:0001964)2.67755357
116neurofilament cytoskeleton organization (GO:0060052)2.67717137
117regulation of glutamate secretion (GO:0014048)2.67595398
118primary amino compound metabolic process (GO:1901160)2.67548463
119sodium ion export (GO:0071436)2.67167183
120neurotransmitter transport (GO:0006836)2.67133395
121gamma-aminobutyric acid transport (GO:0015812)2.66278345
122negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66100727
123response to misfolded protein (GO:0051788)2.65081788
124protein neddylation (GO:0045116)2.64925923
125protein targeting to mitochondrion (GO:0006626)2.63990331
126regulation of synapse structural plasticity (GO:0051823)2.63237393
127synaptic vesicle maturation (GO:0016188)2.62914122
128calcium ion-dependent exocytosis (GO:0017156)2.62787196
129synaptic vesicle endocytosis (GO:0048488)2.62522363
130membrane hyperpolarization (GO:0060081)2.62318073
131membrane depolarization (GO:0051899)2.62085519
132vesicle docking involved in exocytosis (GO:0006904)2.60110093
133acidic amino acid transport (GO:0015800)2.58356193
134establishment of protein localization to mitochondrion (GO:0072655)2.58295664
135locomotory exploration behavior (GO:0035641)2.57895489
136ferric iron transport (GO:0015682)2.57331293
137trivalent inorganic cation transport (GO:0072512)2.57331293
138chemosensory behavior (GO:0007635)2.57159268
139regulation of neurotransmitter secretion (GO:0046928)2.55978543
140ribosomal small subunit biogenesis (GO:0042274)2.55115995
141cerebellar Purkinje cell differentiation (GO:0021702)2.55111463
142regulation of dopamine metabolic process (GO:0042053)2.54531083
143regulation of catecholamine metabolic process (GO:0042069)2.54531083
144positive regulation of neurotransmitter transport (GO:0051590)2.54200198
145regulation of vesicle fusion (GO:0031338)2.53955656
146regulation of feeding behavior (GO:0060259)2.53949930
147response to auditory stimulus (GO:0010996)2.53565423
148response to histamine (GO:0034776)2.53485696
149cell migration in hindbrain (GO:0021535)2.53389638
150ribonucleoside triphosphate biosynthetic process (GO:0009201)2.53379090
151negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.53170596
152synapse assembly (GO:0007416)2.52450145
153dopamine transport (GO:0015872)2.52165983
154regulation of cilium movement (GO:0003352)2.51970361
155long-chain fatty acid biosynthetic process (GO:0042759)2.51952226
156regulation of neurotransmitter uptake (GO:0051580)2.51012421
157inositol phosphate catabolic process (GO:0071545)2.50966115
158cerebellar granule cell differentiation (GO:0021707)2.50577799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71491802
2GBX2_23144817_ChIP-Seq_PC3_Human3.17683641
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66781219
4REST_21632747_ChIP-Seq_MESCs_Mouse2.66016691
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64044849
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50305130
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36033070
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32217545
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29355093
10* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24034305
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.22485570
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.17318857
13TAF15_26573619_Chip-Seq_HEK293_Human2.16461074
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15582940
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10853884
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10033107
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10031979
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09593598
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.07250548
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.06863686
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06493669
22LXR_22292898_ChIP-Seq_THP-1_Human2.03936660
23* TET1_21451524_ChIP-Seq_MESCs_Mouse1.94936281
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.94568299
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91508067
26P68_20966046_ChIP-Seq_HELA_Human1.89339145
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87720732
28CTCF_27219007_Chip-Seq_Bcells_Human1.84499239
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80466757
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.80325447
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79958411
32CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.78608880
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.72737982
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71415088
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69498505
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69398661
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69275850
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69161573
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.69028638
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68270373
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67511117
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67373107
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63376485
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.61279310
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.60760436
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.58045219
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57346071
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53445665
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51260398
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49280870
51SMC4_20622854_ChIP-Seq_HELA_Human1.49214023
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49060740
53* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.49029676
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48731029
55* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.47967818
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.47915069
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47081256
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47081256
59ZNF274_21170338_ChIP-Seq_K562_Hela1.46501294
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46211509
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45742534
62VDR_22108803_ChIP-Seq_LS180_Human1.45173562
63RNF2_27304074_Chip-Seq_NSC_Mouse1.44951416
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43141744
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.42410149
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42187386
67* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42017582
68* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41404647
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.40818702
70FUS_26573619_Chip-Seq_HEK293_Human1.39548293
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.39211065
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38236573
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36294064
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33062141
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32395035
76FOXP1_21924763_ChIP-Seq_HESCs_Human1.31842906
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31764954
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.31725883
79BCL6_27268052_Chip-Seq_Bcells_Human1.31119227
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30006284
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27681609
82OCT4_19829295_ChIP-Seq_ESCs_Human1.27133985
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27129546
84XRN2_22483619_ChIP-Seq_HELA_Human1.26463230
85KDM2B_26808549_Chip-Seq_K562_Human1.24906362
86PHF8_20622854_ChIP-Seq_HELA_Human1.24882459
87* SA1_27219007_Chip-Seq_ERYTHROID_Human1.24216532
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24051014
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23968806
90SA1_27219007_Chip-Seq_Bcells_Human1.22779896
91TET1_21490601_ChIP-Seq_MESCs_Mouse1.22235155
92* SRF_21415370_ChIP-Seq_HL-1_Mouse1.20623969
93* CTCF_20526341_ChIP-Seq_ESCs_Human1.19641392
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19052091
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18802920
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17353317
97* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16253495
98E2F1_20622854_ChIP-Seq_HELA_Human1.15564923
99SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14617911
100DROSHA_22980978_ChIP-Seq_HELA_Human1.14122193
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14077451
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13275743
103BCOR_27268052_Chip-Seq_Bcells_Human1.12593414
104GATA1_26923725_Chip-Seq_HPCs_Mouse1.11528707
105* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11456065
106P300_19829295_ChIP-Seq_ESCs_Human1.11205123
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09918425
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07801584
109CREB1_26743006_Chip-Seq_LNCaP_Human1.07084282
110VDR_21846776_ChIP-Seq_THP-1_Human1.06688135
111CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06384562
112MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06188714
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.06014228
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05269480
115NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.05157039
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04237432
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03950344
118ERA_21632823_ChIP-Seq_H3396_Human1.03014724
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02456722
120DCP1A_22483619_ChIP-Seq_HELA_Human1.02086920
121SMAD4_21799915_ChIP-Seq_A2780_Human1.01958528
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01488057
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00505003
124TAF2_19829295_ChIP-Seq_ESCs_Human1.00449254
125RARA_24833708_ChIP-Seq_LIVER_Mouse1.00110608
126REST_19997604_ChIP-ChIP_NEURONS_Mouse0.99741219
127* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99279903
128ER_23166858_ChIP-Seq_MCF-7_Human0.98517970
129VDR_23849224_ChIP-Seq_CD4+_Human0.98030340
130YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98013444
131GABP_19822575_ChIP-Seq_HepG2_Human0.97092018
132SOX9_26525672_Chip-Seq_HEART_Mouse0.96051453
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96023850
134IGF1R_20145208_ChIP-Seq_DFB_Human0.95535324
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95032593
136TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94324802
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94288396
138KDM2B_26808549_Chip-Seq_DND41_Human0.93523443
139CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90715630
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.90669995
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90515868
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90515868
143ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90052358
144MYC_18555785_ChIP-Seq_MESCs_Mouse0.89157415
145PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87040478
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86734831
147JUN_21703547_ChIP-Seq_K562_Human0.85721802
148DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85685976
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82848405
150RING1B_27294783_Chip-Seq_ESCs_Mouse0.82381370
151IRF1_19129219_ChIP-ChIP_H3396_Human0.82018572
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81936170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.41573218
2MP0004859_abnormal_synaptic_plasticity3.46367811
3MP0003635_abnormal_synaptic_transmissio3.05653939
4MP0009046_muscle_twitch3.02559697
5MP0004270_analgesia2.84948779
6MP0001529_abnormal_vocalization2.75597569
7MP0002064_seizures2.74201275
8MP0001968_abnormal_touch/_nociception2.59813061
9MP0009745_abnormal_behavioral_response2.58998291
10MP0002734_abnormal_mechanical_nocicepti2.57874044
11MP0002272_abnormal_nervous_system2.55367370
12MP0002063_abnormal_learning/memory/cond2.52989271
13MP0002735_abnormal_chemical_nociception2.50256759
14MP0001984_abnormal_olfaction2.42702044
15MP0002572_abnormal_emotion/affect_behav2.40518868
16MP0002736_abnormal_nociception_after2.36788188
17MP0005423_abnormal_somatic_nervous2.34280796
18MP0001486_abnormal_startle_reflex2.26190588
19MP0003123_paternal_imprinting2.25128843
20MP0002184_abnormal_innervation2.12114600
21MP0006276_abnormal_autonomic_nervous2.10877688
22MP0001905_abnormal_dopamine_level2.10811541
23MP0004142_abnormal_muscle_tone2.00030939
24MP0005646_abnormal_pituitary_gland1.97648400
25MP0002067_abnormal_sensory_capabilities1.93039801
26MP0009379_abnormal_foot_pigmentation1.92318055
27MP0006072_abnormal_retinal_apoptosis1.88061338
28MP0001501_abnormal_sleep_pattern1.83135539
29MP0001188_hyperpigmentation1.80759605
30MP0001440_abnormal_grooming_behavior1.80598445
31MP0010386_abnormal_urinary_bladder1.76762584
32MP0001970_abnormal_pain_threshold1.75378200
33MP0008877_abnormal_DNA_methylation1.71423308
34MP0005410_abnormal_fertilization1.70239794
35MP0002557_abnormal_social/conspecific_i1.67077971
36MP0008569_lethality_at_weaning1.66808103
37MP0005386_behavior/neurological_phenoty1.64720321
38MP0004924_abnormal_behavior1.64720321
39MP0005551_abnormal_eye_electrophysiolog1.64564055
40MP0001502_abnormal_circadian_rhythm1.63704943
41MP0002822_catalepsy1.62609138
42MP0002733_abnormal_thermal_nociception1.61911289
43MP0001986_abnormal_taste_sensitivity1.56008740
44MP0000778_abnormal_nervous_system1.55986568
45MP0002653_abnormal_ependyma_morphology1.52099680
46MP0003878_abnormal_ear_physiology1.48621961
47MP0005377_hearing/vestibular/ear_phenot1.48621961
48MP0003122_maternal_imprinting1.45712452
49MP0001348_abnormal_lacrimal_gland1.43386184
50MP0005645_abnormal_hypothalamus_physiol1.42830793
51MP0000631_abnormal_neuroendocrine_gland1.42454552
52MP0004811_abnormal_neuron_physiology1.41863741
53MP0003879_abnormal_hair_cell1.40361685
54MP0000955_abnormal_spinal_cord1.40250216
55MP0002882_abnormal_neuron_morphology1.39160767
56MP0002066_abnormal_motor_capabilities/c1.34632809
57MP0005499_abnormal_olfactory_system1.24079704
58MP0005394_taste/olfaction_phenotype1.24079704
59MP0002229_neurodegeneration1.22491389
60MP0005253_abnormal_eye_physiology1.17981979
61MP0002152_abnormal_brain_morphology1.15515774
62MP0004145_abnormal_muscle_electrophysio1.15316463
63MP0002638_abnormal_pupillary_reflex1.15141640
64MP0006035_abnormal_mitochondrial_morpho1.14871791
65MP0003329_amyloid_beta_deposits1.13964986
66MP0004742_abnormal_vestibular_system1.12668653
67MP0006292_abnormal_olfactory_placode1.11435347
68MP0003698_abnormal_male_reproductive1.10073415
69MP0006036_abnormal_mitochondrial_physio1.08697982
70MP0002752_abnormal_somatic_nervous1.07922930
71MP0002837_dystrophic_cardiac_calcinosis1.07042963
72MP0003634_abnormal_glial_cell1.04923665
73MP0003787_abnormal_imprinting1.03555048
74MP0002160_abnormal_reproductive_system1.03040382
75MP0000920_abnormal_myelination1.00113143
76MP0000013_abnormal_adipose_tissue1.00066844
77MP0001963_abnormal_hearing_physiology1.00065221
78MP0008789_abnormal_olfactory_epithelium0.98789238
79MP0004858_abnormal_nervous_system0.94795571
80MP0004885_abnormal_endolymph0.93828083
81MP0002751_abnormal_autonomic_nervous0.93343279
82MP0008260_abnormal_autophagy0.91651400
83MP0002069_abnormal_eating/drinking_beha0.91555358
84MP0002909_abnormal_adrenal_gland0.90507071
85MP0005670_abnormal_white_adipose0.84685014
86MP0003136_yellow_coat_color0.83947827
87MP0003633_abnormal_nervous_system0.83454724
88MP0009780_abnormal_chondrocyte_physiolo0.82076342
89MP0002234_abnormal_pharynx_morphology0.81580460
90MP0005409_darkened_coat_color0.80889316
91MP0002102_abnormal_ear_morphology0.80866665
92MP0004133_heterotaxia0.79643018
93MP0003632_abnormal_nervous_system0.79288586
94MP0008872_abnormal_physiological_respon0.78050311
95MP0000751_myopathy0.77565843
96MP0001919_abnormal_reproductive_system0.76627487
97MP0005389_reproductive_system_phenotype0.75999629
98MP0005379_endocrine/exocrine_gland_phen0.75972029
99MP0002928_abnormal_bile_duct0.75562580
100MP0001727_abnormal_embryo_implantation0.74901994
101MP0001929_abnormal_gametogenesis0.74783493
102MP0005171_absent_coat_pigmentation0.73404854
103MP0001346_abnormal_lacrimal_gland0.73331245
104MP0002876_abnormal_thyroid_physiology0.73284955
105MP0003861_abnormal_nervous_system0.72696975
106MP0004043_abnormal_pH_regulation0.72373099
107MP0002210_abnormal_sex_determination0.71992007
108MP0003631_nervous_system_phenotype0.71617221
109MP0005195_abnormal_posterior_eye0.71241110
110MP0002090_abnormal_vision0.69729959
111MP0004215_abnormal_myocardial_fiber0.68017250
112MP0001485_abnormal_pinna_reflex0.67387251
113MP0003121_genomic_imprinting0.66602384
114MP0000015_abnormal_ear_pigmentation0.66367226
115MP0002161_abnormal_fertility/fecundity0.64506652
116MP0002163_abnormal_gland_morphology0.63433027
117MP0003646_muscle_fatigue0.63027490
118MP0005535_abnormal_body_temperature0.62530992
119MP0000026_abnormal_inner_ear0.61166955
120MP0005084_abnormal_gallbladder_morpholo0.60254228
121MP0008995_early_reproductive_senescence0.59517539
122MP0004085_abnormal_heartbeat0.59292423

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.64988070
2Acute necrotizing encephalopathy (HP:0006965)4.63921618
3Abnormal mitochondria in muscle tissue (HP:0008316)4.24846637
4Progressive macrocephaly (HP:0004481)3.98767690
5Myokymia (HP:0002411)3.89660945
6Atonic seizures (HP:0010819)3.86693992
7Mitochondrial inheritance (HP:0001427)3.81023380
8Visual hallucinations (HP:0002367)3.72349101
9Acute encephalopathy (HP:0006846)3.58801147
10Epileptic encephalopathy (HP:0200134)3.47201474
11Hepatocellular necrosis (HP:0001404)3.35023406
12Increased CSF lactate (HP:0002490)3.34614355
13Neuroendocrine neoplasm (HP:0100634)3.25136957
14Retinal dysplasia (HP:0007973)3.23398640
15Pheochromocytoma (HP:0002666)3.19428519
16Gait imbalance (HP:0002141)3.12811404
17Medial flaring of the eyebrow (HP:0010747)3.02790433
183-Methylglutaconic aciduria (HP:0003535)3.02427454
19Focal seizures (HP:0007359)3.02015099
20Abnormality of glycolysis (HP:0004366)2.99086936
21Increased serum pyruvate (HP:0003542)2.99086936
22Absence seizures (HP:0002121)2.96001871
23Febrile seizures (HP:0002373)2.94309623
24Hyperthyroidism (HP:0000836)2.92336101
25Limb dystonia (HP:0002451)2.86970168
26Hyperventilation (HP:0002883)2.85331103
27Congenital primary aphakia (HP:0007707)2.81855609
28Nephrogenic diabetes insipidus (HP:0009806)2.81011684
29Abnormal hair whorl (HP:0010721)2.78389443
30Dialeptic seizures (HP:0011146)2.77363448
31Supranuclear gaze palsy (HP:0000605)2.74083292
32Abnormal respiratory motile cilium morphology (HP:0005938)2.72279059
33Abnormal respiratory epithelium morphology (HP:0012253)2.72279059
34Papilledema (HP:0001085)2.69269953
35Leukodystrophy (HP:0002415)2.66449535
36Hepatic necrosis (HP:0002605)2.66437243
37Progressive cerebellar ataxia (HP:0002073)2.65307485
38Optic disc pallor (HP:0000543)2.63435494
39Intention tremor (HP:0002080)2.62264747
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.60463799
41Absent/shortened dynein arms (HP:0200106)2.60463799
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59936237
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59936237
44Increased hepatocellular lipid droplets (HP:0006565)2.58995266
45Polyphagia (HP:0002591)2.56722807
46Renal Fanconi syndrome (HP:0001994)2.54375290
47Cerebral hypomyelination (HP:0006808)2.54120810
48Long foot (HP:0001833)2.53388798
49Failure to thrive in infancy (HP:0001531)2.52178998
50Progressive inability to walk (HP:0002505)2.51746741
51Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.50183936
52Molar tooth sign on MRI (HP:0002419)2.49825444
53Abnormality of midbrain morphology (HP:0002418)2.49825444
54Peripheral hypomyelination (HP:0007182)2.49565542
55Abnormal respiratory motile cilium physiology (HP:0012261)2.45597335
56Poor eye contact (HP:0000817)2.43994923
57Abnormal ciliary motility (HP:0012262)2.42835584
58Poor suck (HP:0002033)2.41955250
59Impaired vibration sensation in the lower limbs (HP:0002166)2.41008854
60Status epilepticus (HP:0002133)2.40690738
61Vaginal atresia (HP:0000148)2.34492359
62Dysmetria (HP:0001310)2.34073663
63Exercise intolerance (HP:0003546)2.32984549
64Diplopia (HP:0000651)2.32032445
65Abnormality of binocular vision (HP:0011514)2.32032445
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31449464
67Severe visual impairment (HP:0001141)2.29186605
68Genital tract atresia (HP:0001827)2.28088991
69Increased serum lactate (HP:0002151)2.27841875
70Lactic acidosis (HP:0003128)2.27442163
71Lipid accumulation in hepatocytes (HP:0006561)2.25709202
72Generalized tonic-clonic seizures (HP:0002069)2.18897739
73Action tremor (HP:0002345)2.18798902
74Poor coordination (HP:0002370)2.16058533
75Pachygyria (HP:0001302)2.15508889
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15286914
77Spastic tetraplegia (HP:0002510)2.14909061
78Anxiety (HP:0000739)2.14800689
79Focal dystonia (HP:0004373)2.14712106
80Postural instability (HP:0002172)2.14032473
81Depression (HP:0000716)2.13772346
82Emotional lability (HP:0000712)2.11837654
83Delusions (HP:0000746)2.11717726
84Spastic gait (HP:0002064)2.08747719
85Epileptiform EEG discharges (HP:0011182)2.08633167
86Unsteady gait (HP:0002317)2.08094783
87Respiratory failure (HP:0002878)2.08068549
88Ankle clonus (HP:0011448)2.07953415
89Increased muscle lipid content (HP:0009058)2.07937420
90Neoplasm of the peripheral nervous system (HP:0100007)2.06132315
91Spastic tetraparesis (HP:0001285)2.05010463
92Pancreatic fibrosis (HP:0100732)2.03789532
93EEG with generalized epileptiform discharges (HP:0011198)2.03560804
94Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03128189
95Hemiparesis (HP:0001269)2.02788017
96Abnormal eating behavior (HP:0100738)2.01610953
97Gaze-evoked nystagmus (HP:0000640)2.01523137
98Abnormality of the corticospinal tract (HP:0002492)2.01179472
99Rhinitis (HP:0012384)1.99264324
100Fetal akinesia sequence (HP:0001989)1.98164772
101Agitation (HP:0000713)1.96845380
102Increased intramyocellular lipid droplets (HP:0012240)1.94802335
103Urinary urgency (HP:0000012)1.94322210
104Lissencephaly (HP:0001339)1.94206974
105Morphological abnormality of the pyramidal tract (HP:0002062)1.93833603
106Esotropia (HP:0000565)1.92855131
107Abnormality of the labia minora (HP:0012880)1.92831199
108Abnormality of renal resorption (HP:0011038)1.92603319
109Broad distal phalanx of finger (HP:0009836)1.91722261
110Akinesia (HP:0002304)1.91302838
111Cerebral edema (HP:0002181)1.91180283
112Type II lissencephaly (HP:0007260)1.90800847
113Annular pancreas (HP:0001734)1.90412056
114Hypsarrhythmia (HP:0002521)1.89988830
115Truncal ataxia (HP:0002078)1.89970501
116Specific learning disability (HP:0001328)1.88756295
117Hypoplasia of the brainstem (HP:0002365)1.87768688
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87768688
119Torticollis (HP:0000473)1.86491536
120Sensory axonal neuropathy (HP:0003390)1.86290634
121Broad-based gait (HP:0002136)1.85299905
122Severe global developmental delay (HP:0011344)1.85153747
123Sleep apnea (HP:0010535)1.84622224
124Generalized aminoaciduria (HP:0002909)1.84521125
125Septo-optic dysplasia (HP:0100842)1.84430468
126CNS hypomyelination (HP:0003429)1.83091011
127Muscular hypotonia of the trunk (HP:0008936)1.82104824
128Inability to walk (HP:0002540)1.80941729
129Abnormal social behavior (HP:0012433)1.80865260
130Impaired social interactions (HP:0000735)1.80865260
131Dysdiadochokinesis (HP:0002075)1.80314248
132True hermaphroditism (HP:0010459)1.80148716
133Craniofacial dystonia (HP:0012179)1.79909532
134Bradykinesia (HP:0002067)1.77295811
135Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76931679
136Urinary bladder sphincter dysfunction (HP:0002839)1.76733332
137Broad foot (HP:0001769)1.74744539
138Progressive microcephaly (HP:0000253)1.74703179
139Amblyopia (HP:0000646)1.74698642
140Reticulocytopenia (HP:0001896)1.72376831
141Double outlet right ventricle (HP:0001719)1.70348972
142Congenital malformation of the right heart (HP:0011723)1.70348972
143Amyotrophic lateral sclerosis (HP:0007354)1.68535607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.62063996
2CASK3.61787881
3MAP3K113.38208108
4CDK192.92112592
5PRPF4B2.55784348
6MAP3K42.55342394
7CCNB12.43498438
8MAP3K122.41924602
9MAP2K72.40582072
10NME12.40129148
11PNCK2.34503213
12NTRK31.97840438
13MINK11.93635801
14MAPK131.90724311
15UHMK11.90113080
16BRAF1.89579767
17STK161.85474818
18DYRK21.78335754
19CAMKK21.77673706
20BUB11.71905689
21OXSR11.64739844
22EPHA41.55359856
23NTRK21.53306978
24BCKDK1.53304804
25AKT31.49477946
26PLK21.43975288
27TESK21.41611887
28DAPK11.40476743
29BMPR1B1.34142112
30PAK61.33690948
31DAPK21.33599232
32TNIK1.33079933
33ARAF1.32361355
34MARK21.28534509
35PRKCG1.26895535
36BMPR21.26317457
37MAP2K41.24122300
38MAP3K91.23795528
39VRK21.22654556
40CDK51.21883210
41CDK181.19089036
42SGK4941.17312372
43SGK2231.17312372
44CDK151.16047354
45CDK141.10254530
46CDK11A1.07058761
47DYRK1A1.06821555
48VRK11.05713651
49GRK51.05459270
50TSSK61.03185101
51TYRO31.03093040
52MAP4K20.97734889
53KSR20.97654072
54PDK30.97450502
55PDK40.97450502
56PRKD30.94316603
57STK110.94198577
58CDK80.92697413
59CAMK2B0.91413418
60BCR0.90728302
61NEK10.90259292
62CSNK1G30.86588116
63SGK20.85148521
64SIK30.83623339
65STK390.83311927
66CAMK2A0.82978109
67PAK30.82335359
68WNK40.82144803
69ADRBK10.81528068
70ADRBK20.80810729
71MAPK120.80033675
72BRSK10.78909129
73RPS6KA20.78888761
74PTK2B0.76236592
75CSNK1G20.75645500
76PHKG10.75177668
77PHKG20.75177668
78PLK30.73893086
79PLK40.72672777
80PIM20.72594384
81CSNK1A1L0.71849138
82EIF2AK30.71580748
83TRIB30.68981134
84CAMKK10.68493101
85GRK70.68284114
86MAP2K60.68057501
87PRKCI0.67770067
88DYRK1B0.67551488
89ACVR1B0.67316846
90WNK30.65514443
91CAMK40.64298658
92PASK0.64151142
93TNK20.64130836
94ROCK20.63433132
95LRRK20.62040563
96AURKA0.61909036
97NTRK10.61439811
98MAP3K10.60987150
99ERBB30.60978195
100CAMK1G0.60221861
101FES0.59082210
102LIMK10.58373542
103YES10.58064207
104CAMK2D0.57889982
105RIPK40.55861664
106CAMK2G0.55580712
107DMPK0.55359074
108SIK20.53572203
109IRAK30.53406218
110PRKCE0.51629920
111KSR10.48899832
112CSNK1G10.48225270
113DYRK30.48192971
114CAMK1D0.46903915
115PINK10.46681339
116MAP3K60.45377733
117PDK10.45217448
118PRKACA0.44501035
119CDK30.44396890
120IRAK20.44085398
121PDPK10.43762480
122AKT20.43651889
123MAPK150.43300990
124MAP4K10.43161824
125PRKD20.43057811
126ABL20.41358883
127PKN10.41087965
128INSRR0.39726295
129STK380.38404246
130PRKAA10.37136466
131ERBB40.37099911
132TESK10.36448821
133PRKCH0.36255722
134PRKCZ0.33743080
135CAMK10.32569822
136NEK60.32372205
137DAPK30.32262018

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.93632459
2Nicotine addiction_Homo sapiens_hsa050333.52807633
3Synaptic vesicle cycle_Homo sapiens_hsa047213.46028594
4Parkinsons disease_Homo sapiens_hsa050123.24660238
5Proteasome_Homo sapiens_hsa030502.72134524
6Collecting duct acid secretion_Homo sapiens_hsa049662.68970052
7Huntingtons disease_Homo sapiens_hsa050162.52287534
8Alzheimers disease_Homo sapiens_hsa050102.50991287
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40359953
10Sulfur relay system_Homo sapiens_hsa041222.37584115
11GABAergic synapse_Homo sapiens_hsa047272.20128517
12Protein export_Homo sapiens_hsa030602.15666608
13Cardiac muscle contraction_Homo sapiens_hsa042602.07895403
14Morphine addiction_Homo sapiens_hsa050322.04628837
15Olfactory transduction_Homo sapiens_hsa047401.97894820
16Vibrio cholerae infection_Homo sapiens_hsa051101.96091843
17Circadian entrainment_Homo sapiens_hsa047131.85619055
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85290486
19Amphetamine addiction_Homo sapiens_hsa050311.82476532
20Glutamatergic synapse_Homo sapiens_hsa047241.77984182
21Taste transduction_Homo sapiens_hsa047421.72745424
22Dopaminergic synapse_Homo sapiens_hsa047281.71063127
23RNA polymerase_Homo sapiens_hsa030201.67221803
24Serotonergic synapse_Homo sapiens_hsa047261.61888063
25Insulin secretion_Homo sapiens_hsa049111.59214350
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57001926
27Long-term potentiation_Homo sapiens_hsa047201.53170014
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50970881
29Ribosome_Homo sapiens_hsa030101.41489611
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36558928
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33712004
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32277833
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30149140
34Cholinergic synapse_Homo sapiens_hsa047251.25061720
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24869699
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23340763
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22113389
38Butanoate metabolism_Homo sapiens_hsa006501.19082752
39Cocaine addiction_Homo sapiens_hsa050301.17797521
40Base excision repair_Homo sapiens_hsa034101.15172184
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13021849
42Long-term depression_Homo sapiens_hsa047301.09559740
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01202211
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00987299
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00217626
46Vitamin B6 metabolism_Homo sapiens_hsa007500.98496591
47Oocyte meiosis_Homo sapiens_hsa041140.98477165
48Calcium signaling pathway_Homo sapiens_hsa040200.96195636
49Phototransduction_Homo sapiens_hsa047440.95685579
50Salivary secretion_Homo sapiens_hsa049700.95210070
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92784005
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88665216
53Pyrimidine metabolism_Homo sapiens_hsa002400.86396048
54Oxytocin signaling pathway_Homo sapiens_hsa049210.86153361
55Purine metabolism_Homo sapiens_hsa002300.85753412
56Biosynthesis of amino acids_Homo sapiens_hsa012300.84581010
57Alcoholism_Homo sapiens_hsa050340.84456743
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84300426
59Spliceosome_Homo sapiens_hsa030400.84124501
60Fatty acid metabolism_Homo sapiens_hsa012120.80998338
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79722966
62Basal transcription factors_Homo sapiens_hsa030220.78665391
63Gastric acid secretion_Homo sapiens_hsa049710.78584694
64Folate biosynthesis_Homo sapiens_hsa007900.78523749
65Regulation of autophagy_Homo sapiens_hsa041400.78293673
66Nucleotide excision repair_Homo sapiens_hsa034200.76761459
67Fatty acid elongation_Homo sapiens_hsa000620.73028971
68Gap junction_Homo sapiens_hsa045400.70311654
69Fatty acid biosynthesis_Homo sapiens_hsa000610.70217946
70Steroid biosynthesis_Homo sapiens_hsa001000.70065092
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68061292
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66674895
73RNA degradation_Homo sapiens_hsa030180.65453284
74RNA transport_Homo sapiens_hsa030130.65209866
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64124078
76VEGF signaling pathway_Homo sapiens_hsa043700.62328972
77Notch signaling pathway_Homo sapiens_hsa043300.62059824
78Renin secretion_Homo sapiens_hsa049240.61903025
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61093295
80Mismatch repair_Homo sapiens_hsa034300.60955681
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60540993
82Pyruvate metabolism_Homo sapiens_hsa006200.60515414
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60300987
84Rheumatoid arthritis_Homo sapiens_hsa053230.58751817
85* Endocytosis_Homo sapiens_hsa041440.58320369
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58177613
87Axon guidance_Homo sapiens_hsa043600.53382806
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51585791
89Glioma_Homo sapiens_hsa052140.50498465
90Arginine and proline metabolism_Homo sapiens_hsa003300.49802834
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49762795
92N-Glycan biosynthesis_Homo sapiens_hsa005100.49729127
93Peroxisome_Homo sapiens_hsa041460.48764632
94DNA replication_Homo sapiens_hsa030300.44978345
95beta-Alanine metabolism_Homo sapiens_hsa004100.44540524
96cAMP signaling pathway_Homo sapiens_hsa040240.43785495
97Phagosome_Homo sapiens_hsa041450.43614232
98Carbon metabolism_Homo sapiens_hsa012000.43524862
99GnRH signaling pathway_Homo sapiens_hsa049120.43031868
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42439206
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.42051667
102Ether lipid metabolism_Homo sapiens_hsa005650.41976946
103Metabolic pathways_Homo sapiens_hsa011000.41743024
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38886110
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38406063
106Circadian rhythm_Homo sapiens_hsa047100.38198049
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36598280
108Type I diabetes mellitus_Homo sapiens_hsa049400.36498897
109Estrogen signaling pathway_Homo sapiens_hsa049150.36238818
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35705750
111AMPK signaling pathway_Homo sapiens_hsa041520.35116435
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34921771
113Sphingolipid metabolism_Homo sapiens_hsa006000.33417729
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.32102916
115ErbB signaling pathway_Homo sapiens_hsa040120.32067406
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31326120
117mRNA surveillance pathway_Homo sapiens_hsa030150.31064853
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29626580
119Renal cell carcinoma_Homo sapiens_hsa052110.28410306
120Pancreatic secretion_Homo sapiens_hsa049720.27228714
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.26840191
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26821691
123Glucagon signaling pathway_Homo sapiens_hsa049220.26747879
124Thyroid hormone synthesis_Homo sapiens_hsa049180.26419472
125Melanogenesis_Homo sapiens_hsa049160.24696077
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24172343
127MAPK signaling pathway_Homo sapiens_hsa040100.23567859
128Inositol phosphate metabolism_Homo sapiens_hsa005620.23480207
129Type II diabetes mellitus_Homo sapiens_hsa049300.22085647

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