PARG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.09866946
2nuclear pore organization (GO:0006999)5.89819489
3DNA unwinding involved in DNA replication (GO:0006268)4.63235545
4regulation of RNA export from nucleus (GO:0046831)4.57735330
5pore complex assembly (GO:0046931)4.56056540
6mitotic sister chromatid cohesion (GO:0007064)4.47406843
7protein localization to kinetochore (GO:0034501)4.38371933
8mitotic nuclear envelope disassembly (GO:0007077)4.32510016
9mitotic chromosome condensation (GO:0007076)4.31646790
10regulation of histone H3-K9 methylation (GO:0051570)4.21038469
11regulation of spindle organization (GO:0090224)4.14214753
12nuclear envelope disassembly (GO:0051081)4.13560956
13membrane disassembly (GO:0030397)4.13560956
14DNA replication-dependent nucleosome assembly (GO:0006335)4.12529399
15DNA replication-dependent nucleosome organization (GO:0034723)4.12529399
16pre-miRNA processing (GO:0031054)4.09842916
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.06338359
18mitotic metaphase plate congression (GO:0007080)4.04344629
19negative regulation of histone methylation (GO:0031061)3.97352329
20folic acid-containing compound biosynthetic process (GO:0009396)3.91899803
21double-strand break repair via nonhomologous end joining (GO:0006303)3.87642837
22non-recombinational repair (GO:0000726)3.87642837
23DNA synthesis involved in DNA repair (GO:0000731)3.85992153
24DNA geometric change (GO:0032392)3.85110010
25histone H2A monoubiquitination (GO:0035518)3.83878231
26DNA duplex unwinding (GO:0032508)3.83694139
27regulation of mitotic spindle organization (GO:0060236)3.82998035
28establishment of integrated proviral latency (GO:0075713)3.79895155
29sister chromatid segregation (GO:0000819)3.78207252
30metaphase plate congression (GO:0051310)3.76866816
31regulation of DNA endoreduplication (GO:0032875)3.75788219
32positive regulation of chromosome segregation (GO:0051984)3.71978136
33DNA double-strand break processing (GO:0000729)3.71293285
34telomere maintenance via semi-conservative replication (GO:0032201)3.70058712
35regulation of nucleobase-containing compound transport (GO:0032239)3.66723880
36protein localization to chromosome, centromeric region (GO:0071459)3.63697673
37monoubiquitinated protein deubiquitination (GO:0035520)3.56708384
38regulation of helicase activity (GO:0051095)3.53522700
39chromatin assembly (GO:0031497)3.52694687
40IMP biosynthetic process (GO:0006188)3.50351578
41mitotic sister chromatid segregation (GO:0000070)3.50335536
42nucleobase biosynthetic process (GO:0046112)3.49859401
43heterochromatin organization (GO:0070828)3.48925838
44synapsis (GO:0007129)3.47855179
45DNA replication initiation (GO:0006270)3.47412231
46ribosome assembly (GO:0042255)3.42005359
47telomere maintenance via recombination (GO:0000722)3.39011626
48positive regulation of mitotic sister chromatid separation (GO:1901970)3.38445126
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.38445126
50positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.38445126
51mitotic recombination (GO:0006312)3.37894993
52nuclear envelope organization (GO:0006998)3.34116195
53purine nucleobase biosynthetic process (GO:0009113)3.33814974
54regulation of sister chromatid cohesion (GO:0007063)3.33219056
55DNA replication checkpoint (GO:0000076)3.32426925
56histone exchange (GO:0043486)3.31145668
57regulation of chromosome segregation (GO:0051983)3.30780981
58protein K6-linked ubiquitination (GO:0085020)3.29751536
59kinetochore organization (GO:0051383)3.29385764
60paraxial mesoderm development (GO:0048339)3.28691295
61chromatin assembly or disassembly (GO:0006333)3.28149576
62regulation of centrosome cycle (GO:0046605)3.28020363
63regulation of translational termination (GO:0006449)3.25412294
64dosage compensation (GO:0007549)3.20702380
65establishment of chromosome localization (GO:0051303)3.20684984
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20419789
67meiotic chromosome segregation (GO:0045132)3.18795038
68spindle checkpoint (GO:0031577)3.18046851
69regulation of translational fidelity (GO:0006450)3.14815857
70regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12343123
71ATP-dependent chromatin remodeling (GO:0043044)3.11962736
72attachment of spindle microtubules to kinetochore (GO:0008608)3.11753492
73spindle assembly checkpoint (GO:0071173)3.11467709
74gene silencing by RNA (GO:0031047)3.09681627
75DNA replication-independent nucleosome assembly (GO:0006336)3.08971335
76DNA replication-independent nucleosome organization (GO:0034724)3.08971335
77regulation of centrosome duplication (GO:0010824)3.08943965
78DNA conformation change (GO:0071103)3.08894683
79chromatin remodeling at centromere (GO:0031055)3.08846955
80mitotic spindle checkpoint (GO:0071174)3.08304564
81spindle assembly involved in mitosis (GO:0090307)3.08211481
82DNA strand elongation involved in DNA replication (GO:0006271)3.07893582
83IMP metabolic process (GO:0046040)3.05872894
84mitotic spindle assembly checkpoint (GO:0007094)3.04854428
85negative regulation of chromosome segregation (GO:0051985)3.04770152
86regulation of posttranscriptional gene silencing (GO:0060147)3.04131629
87regulation of gene silencing by miRNA (GO:0060964)3.04131629
88regulation of gene silencing by RNA (GO:0060966)3.04131629
89protein complex localization (GO:0031503)3.03489475
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03464174
91somatic hypermutation of immunoglobulin genes (GO:0016446)3.01477234
92somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01477234
93DNA ligation (GO:0006266)2.99990737
94negative regulation of mitotic sister chromatid separation (GO:2000816)2.98390216
95negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98390216
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98390216
97negative regulation of sister chromatid segregation (GO:0033046)2.98390216
98sister chromatid cohesion (GO:0007062)2.97638363
99protein localization to chromosome (GO:0034502)2.97144142
100histone mRNA catabolic process (GO:0071044)2.96187198
101regulation of centriole replication (GO:0046599)2.95670077
102NLS-bearing protein import into nucleus (GO:0006607)2.94822612
103regulation of mitotic sister chromatid separation (GO:0010965)2.93442718
104regulation of mitotic sister chromatid segregation (GO:0033047)2.93442718
105regulation of sister chromatid segregation (GO:0033045)2.93442718
106translesion synthesis (GO:0019985)2.93374203
107regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92690761
108regulation of mitotic spindle checkpoint (GO:1903504)2.92690761
109negative regulation of DNA repair (GO:0045738)2.92459162
110DNA topological change (GO:0006265)2.91645443
111mRNA transport (GO:0051028)2.91271964
112resolution of meiotic recombination intermediates (GO:0000712)2.89664200
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.88850578
114chromosome condensation (GO:0030261)2.87918317
115DNA strand elongation (GO:0022616)2.87730121
116histone-serine phosphorylation (GO:0035404)2.87515877
117CENP-A containing nucleosome assembly (GO:0034080)2.87481614
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87310190
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87022272
120formation of translation preinitiation complex (GO:0001731)2.85911520
121telomere maintenance (GO:0000723)2.85263626
122regulation of telomere maintenance via telomerase (GO:0032210)2.84502728
123negative regulation of fibroblast apoptotic process (GO:2000270)2.83379410
124telomere organization (GO:0032200)2.83195279
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.79833327
126DNA packaging (GO:0006323)2.76669666
127telomere maintenance via telomere lengthening (GO:0010833)2.75175988
128positive regulation of cell cycle checkpoint (GO:1901978)2.72499252
129regulation of spindle checkpoint (GO:0090231)2.66665842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.23715684
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.18390504
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.96840048
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.61284820
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.26857893
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.00689670
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90219129
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.63274483
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51134147
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.32314623
11AR_21909140_ChIP-Seq_LNCAP_Human2.31187420
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28288470
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23580914
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22174004
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21332197
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19364819
17MYC_22102868_ChIP-Seq_BL_Human2.14705086
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04145293
19E2F7_22180533_ChIP-Seq_HELA_Human10.3175700
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95860221
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86053071
22FUS_26573619_Chip-Seq_HEK293_Human1.84289739
23* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81340748
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79753243
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75393974
26IGF1R_20145208_ChIP-Seq_DFB_Human1.73623433
27XRN2_22483619_ChIP-Seq_HELA_Human1.73053316
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71324765
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68130763
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68124198
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64537729
32VDR_23849224_ChIP-Seq_CD4+_Human1.64030093
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63791670
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61307797
35KDM5A_27292631_Chip-Seq_BREAST_Human1.61085102
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58804276
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54164670
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53013417
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50195709
40CIITA_25753668_ChIP-Seq_RAJI_Human1.49158549
41EWS_26573619_Chip-Seq_HEK293_Human1.48999402
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48514627
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.47861724
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.45361852
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44714706
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.43536510
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41895465
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41259580
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39781369
50ELK1_19687146_ChIP-ChIP_HELA_Human1.39206964
51FOXP3_21729870_ChIP-Seq_TREG_Human1.38269238
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34960546
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.34176366
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34080533
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33530493
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33530493
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33530493
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32458419
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30557068
60SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30459948
61* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28892798
62TFEB_21752829_ChIP-Seq_HELA_Human1.28308628
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27279148
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25841022
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.22721312
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22533856
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.21720790
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21292420
69GABP_19822575_ChIP-Seq_HepG2_Human1.17518653
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16809909
71* NANOG_16153702_ChIP-ChIP_HESCs_Human1.16328263
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14670287
73TTF2_22483619_ChIP-Seq_HELA_Human1.14301814
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.14293742
75DCP1A_22483619_ChIP-Seq_HELA_Human1.14180463
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12678658
77MYC_18940864_ChIP-ChIP_HL60_Human1.12469829
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09733025
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09674590
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09344456
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09318460
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08430848
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07662300
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07408296
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06937718
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06878302
87CHD1_26751641_Chip-Seq_LNCaP_Human1.06479568
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06429785
89* SOX2_16153702_ChIP-ChIP_HESCs_Human1.05999881
90* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03959201
91* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03290329
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.02338547
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02175433
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00881739
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00692621
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00200839
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00089047
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98568365
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98566940
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98315048
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97063530
102FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96895352
103SOX9_26525672_Chip-Seq_HEART_Mouse0.96177631
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93346231
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92737230
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91352076
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91102626
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90984925
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90592384
110MYB_26560356_Chip-Seq_TH1_Human0.88337249
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88308116
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87160521
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87148018
114EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87055139
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85802728
116THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85491926
117TCF7_22412390_ChIP-Seq_EML_Mouse0.85272373
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84619901
119ZNF263_19887448_ChIP-Seq_K562_Human0.84371245
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83834426
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82979096
122POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82498727
123MYB_26560356_Chip-Seq_TH2_Human0.81950743
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81360620
125P300_19829295_ChIP-Seq_ESCs_Human0.80919851
126VDR_21846776_ChIP-Seq_THP-1_Human0.80617148
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80182425
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.79168647
129TAF15_26573619_Chip-Seq_HEK293_Human0.76887825
130TBX3_20139965_ChIP-Seq_ESCs_Mouse0.75332609
131IRF1_19129219_ChIP-ChIP_H3396_Human0.75137908
132TBX3_20139965_ChIP-Seq_MESCs_Mouse0.73762463
133* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73092450
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.71889908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.91102187
2* MP0003693_abnormal_embryo_hatching3.75040305
3MP0003111_abnormal_nucleus_morphology3.66746741
4MP0010352_gastrointestinal_tract_polyps3.64102407
5MP0004957_abnormal_blastocyst_morpholog3.57284154
6MP0008057_abnormal_DNA_replication3.54009245
7MP0003077_abnormal_cell_cycle3.38108649
8MP0010307_abnormal_tumor_latency3.11420054
9MP0003123_paternal_imprinting2.97399913
10MP0005076_abnormal_cell_differentiation2.66441634
11MP0008877_abnormal_DNA_methylation2.62919919
12MP0001730_embryonic_growth_arrest2.60057313
13MP0008058_abnormal_DNA_repair2.42284280
14* MP0000350_abnormal_cell_proliferation2.36937422
15MP0008007_abnormal_cellular_replicative2.31603944
16MP0003941_abnormal_skin_development2.31336751
17MP0003705_abnormal_hypodermis_morpholog2.15816361
18MP0004233_abnormal_muscle_weight2.08631358
19MP0001672_abnormal_embryogenesis/_devel1.97428732
20MP0005380_embryogenesis_phenotype1.97428732
21MP0002396_abnormal_hematopoietic_system1.95336383
22MP0008932_abnormal_embryonic_tissue1.95065124
23MP0002084_abnormal_developmental_patter1.91788600
24MP0001697_abnormal_embryo_size1.90299593
25MP0009697_abnormal_copulation1.87020660
26MP0003984_embryonic_growth_retardation1.81974338
27MP0002086_abnormal_extraembryonic_tissu1.80882198
28MP0002088_abnormal_embryonic_growth/wei1.80209544
29MP0003890_abnormal_embryonic-extraembry1.79398134
30MP0004197_abnormal_fetal_growth/weight/1.79127176
31MP0003121_genomic_imprinting1.75854766
32MP0002085_abnormal_embryonic_tissue1.72019371
33MP0000537_abnormal_urethra_morphology1.63152402
34MP0003136_yellow_coat_color1.62317063
35MP0002080_prenatal_lethality1.61917744
36MP0003786_premature_aging1.60049564
37MP0004808_abnormal_hematopoietic_stem1.55818145
38MP0010234_abnormal_vibrissa_follicle1.55410860
39MP0000569_abnormal_digit_pigmentation1.50232706
40MP0003385_abnormal_body_wall1.37909764
41MP0002233_abnormal_nose_morphology1.37232896
42MP0003646_muscle_fatigue1.34505204
43MP0006054_spinal_hemorrhage1.32417702
44MP0003567_abnormal_fetal_cardiomyocyte1.29466875
45MP0009703_decreased_birth_body1.29338079
46MP0003300_gastrointestinal_ulcer1.26514132
47MP0000490_abnormal_crypts_of1.24211432
48MP0003566_abnormal_cell_adhesion1.23865290
49MP0001849_ear_inflammation1.21077561
50MP0001293_anophthalmia1.20201455
51MP0001286_abnormal_eye_development1.20079008
52MP0000428_abnormal_craniofacial_morphol1.19939035
53MP0009672_abnormal_birth_weight1.18360131
54* MP0000313_abnormal_cell_death1.18169699
55MP0009053_abnormal_anal_canal1.15846775
56MP0006035_abnormal_mitochondrial_morpho1.15012975
57MP0002166_altered_tumor_susceptibility1.14907399
58MP0000733_abnormal_muscle_development1.14331359
59MP0002019_abnormal_tumor_incidence1.14306858
60MP0004185_abnormal_adipocyte_glucose1.13997175
61MP0001299_abnormal_eye_distance/1.13499413
62MP0002210_abnormal_sex_determination1.11526515
63MP0000579_abnormal_nail_morphology1.09908075
64MP0002009_preneoplasia1.09242343
65MP0010030_abnormal_orbit_morphology1.07786031
66MP0003937_abnormal_limbs/digits/tail_de1.07585343
67MP0002269_muscular_atrophy1.06285219
68MP0004264_abnormal_extraembryonic_tissu1.05644365
69MP0001915_intracranial_hemorrhage1.05148414
70MP0000703_abnormal_thymus_morphology1.04392503
71MP0004084_abnormal_cardiac_muscle1.03746590
72MP0001145_abnormal_male_reproductive1.03678820
73MP0003763_abnormal_thymus_physiology1.02646049
74MP0003787_abnormal_imprinting1.02528801
75MP0000749_muscle_degeneration1.01745482
76MP0005248_abnormal_Harderian_gland1.01378774
77MP0002092_abnormal_eye_morphology1.01164761
78MP0002877_abnormal_melanocyte_morpholog1.00955752
79MP0005621_abnormal_cell_physiology1.00061403
80MP0005023_abnormal_wound_healing0.99549837
81MP0004272_abnormal_basement_membrane0.99236730
82MP0003119_abnormal_digestive_system0.96763127
83MP0002006_tumorigenesis0.96610262
84MP0002160_abnormal_reproductive_system0.96334624
85MP0000358_abnormal_cell_content/0.91989144
86MP0005384_cellular_phenotype0.91146398
87MP0003755_abnormal_palate_morphology0.90286034
88MP0001929_abnormal_gametogenesis0.89547865
89MP0009278_abnormal_bone_marrow0.88680984
90MP0006072_abnormal_retinal_apoptosis0.86015612
91MP0005397_hematopoietic_system_phenotyp0.85965615
92MP0001545_abnormal_hematopoietic_system0.85965615
93MP0005623_abnormal_meninges_morphology0.83958432
94MP0002398_abnormal_bone_marrow0.83548937
95MP0000653_abnormal_sex_gland0.82855413
96MP0010678_abnormal_skin_adnexa0.82372189
97MP0003091_abnormal_cell_migration0.82018474
98MP0001661_extended_life_span0.80024859
99MP0000647_abnormal_sebaceous_gland0.79019497
100MP0004036_abnormal_muscle_relaxation0.77654018
101MP0000427_abnormal_hair_cycle0.77152632
102MP0002925_abnormal_cardiovascular_devel0.76828283
103MP0000371_diluted_coat_color0.76076700
104MP0003698_abnormal_male_reproductive0.75986518
105MP0002697_abnormal_eye_size0.75028388
106MP0001346_abnormal_lacrimal_gland0.74957785
107MP0002254_reproductive_system_inflammat0.73628917
108MP0008789_abnormal_olfactory_epithelium0.73530430
109MP0000432_abnormal_head_morphology0.73424792
110MP0000751_myopathy0.73333936
111MP0003315_abnormal_perineum_morphology0.73235817
112MP0005391_vision/eye_phenotype0.73230785
113MP0003718_maternal_effect0.72925680
114MP0003115_abnormal_respiratory_system0.72909932
115MP0003935_abnormal_craniofacial_develop0.72545305
116MP0002111_abnormal_tail_morphology0.71829210
117MP0005499_abnormal_olfactory_system0.71159258
118MP0005394_taste/olfaction_phenotype0.71159258
119MP0002722_abnormal_immune_system0.71130909
120MP0002102_abnormal_ear_morphology0.71072173
121MP0003448_altered_tumor_morphology0.69412785
122MP0000383_abnormal_hair_follicle0.68106287
123MP0004087_abnormal_muscle_fiber0.67572128
124MP0010630_abnormal_cardiac_muscle0.67234106
125MP0000858_altered_metastatic_potential0.66809602
126MP0003221_abnormal_cardiomyocyte_apopto0.66525307
127MP0002114_abnormal_axial_skeleton0.66327822
128MP0002938_white_spotting0.65803250
129MP0000477_abnormal_intestine_morphology0.65258945
130MP0005187_abnormal_penis_morphology0.65129448
131MP0000689_abnormal_spleen_morphology0.61846291
132MP0005367_renal/urinary_system_phenotyp0.61309549
133MP0000516_abnormal_urinary_system0.61309549
134MP0000377_abnormal_hair_follicle0.60225907
135MP0000627_abnormal_mammary_gland0.59978684
136MP0008770_decreased_survivor_rate0.59814869
137MP0003861_abnormal_nervous_system0.59409204

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.11006658
2Colon cancer (HP:0003003)3.71082214
3Abnormality of the astrocytes (HP:0100707)3.35086259
4Astrocytoma (HP:0009592)3.35086259
5Nephroblastoma (Wilms tumor) (HP:0002667)3.28361442
6Volvulus (HP:0002580)3.19297499
7Embryonal renal neoplasm (HP:0011794)3.12563746
8Medulloblastoma (HP:0002885)3.05440449
9Biliary tract neoplasm (HP:0100574)3.03460873
10Abnormality of the labia minora (HP:0012880)2.92581302
11High anterior hairline (HP:0009890)2.88327459
12Birth length less than 3rd percentile (HP:0003561)2.87727543
13Rhabdomyosarcoma (HP:0002859)2.86180300
14Selective tooth agenesis (HP:0001592)2.85243645
15Agnosia (HP:0010524)2.84273419
16Glioma (HP:0009733)2.83828375
17Chromsome breakage (HP:0040012)2.83337037
18Abnormality of chromosome stability (HP:0003220)2.78160686
19Neoplasm of the oral cavity (HP:0100649)2.75492107
20Prominent nose (HP:0000448)2.69899604
21Deviation of the thumb (HP:0009603)2.68423685
22Impulsivity (HP:0100710)2.65219994
23Proximal placement of thumb (HP:0009623)2.62318732
24Pelvic girdle muscle weakness (HP:0003749)2.55473936
25Basal cell carcinoma (HP:0002671)2.48779446
26Sandal gap (HP:0001852)2.42327185
27Abnormality of the fingertips (HP:0001211)2.39887705
28Rimmed vacuoles (HP:0003805)2.39885655
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37053554
30Short 4th metacarpal (HP:0010044)2.37053554
31Malignant gastrointestinal tract tumors (HP:0006749)2.35673023
32Gastrointestinal carcinoma (HP:0002672)2.35673023
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30734012
34Cafe-au-lait spot (HP:0000957)2.28384683
35Sparse lateral eyebrow (HP:0005338)2.26959350
36Facial hemangioma (HP:0000329)2.26205519
37Cortical dysplasia (HP:0002539)2.26001796
38Hepatoblastoma (HP:0002884)2.24011309
39Neoplasm of striated muscle (HP:0009728)2.21480386
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.20900133
41Heterotopia (HP:0002282)2.20696446
42Gonadotropin excess (HP:0000837)2.19989038
43Shoulder girdle muscle weakness (HP:0003547)2.18930650
44Abnormal lung lobation (HP:0002101)2.16132759
45Neoplasm of the pancreas (HP:0002894)2.15595602
46Absent radius (HP:0003974)2.15508274
47Ankle contracture (HP:0006466)2.13933240
48Degeneration of anterior horn cells (HP:0002398)2.13815570
49Abnormality of the anterior horn cell (HP:0006802)2.13815570
50Patellar aplasia (HP:0006443)2.13176733
51Amaurosis fugax (HP:0100576)2.12711900
52Long eyelashes (HP:0000527)2.12260159
53Abnormal biliary tract morphology (HP:0012440)2.12170362
54Missing ribs (HP:0000921)2.11171767
55Increased nuchal translucency (HP:0010880)2.08157346
56Ectopic kidney (HP:0000086)2.07279781
57Spinal muscular atrophy (HP:0007269)2.06693366
58Abnormality of the musculature of the pelvis (HP:0001469)2.03207986
59Abnormality of the hip-girdle musculature (HP:0001445)2.03207986
60High pitched voice (HP:0001620)2.02974889
61Breast hypoplasia (HP:0003187)2.02229837
62Aplasia involving forearm bones (HP:0009822)2.01348162
63Absent forearm bone (HP:0003953)2.01348162
64Aplasia/Hypoplasia of the patella (HP:0006498)1.99346772
65Fibular aplasia (HP:0002990)1.98975652
66Facial cleft (HP:0002006)1.96974032
67Anal stenosis (HP:0002025)1.95609283
68Cerebral aneurysm (HP:0004944)1.93442185
69Sloping forehead (HP:0000340)1.93264081
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91954193
71Abnormality of the duodenum (HP:0002246)1.91829061
72Meckel diverticulum (HP:0002245)1.90395935
73Neoplasm of the small intestine (HP:0100833)1.89622296
74Truncal obesity (HP:0001956)1.88873750
75Myelodysplasia (HP:0002863)1.87598858
76Resting tremor (HP:0002322)1.86548451
77Multiple enchondromatosis (HP:0005701)1.86460454
78Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85434111
79Broad thumb (HP:0011304)1.85334872
8011 pairs of ribs (HP:0000878)1.85106042
81Short humerus (HP:0005792)1.84275115
82Abnormality of the ileum (HP:0001549)1.84177562
83Absent thumb (HP:0009777)1.83751141
84Exercise-induced muscle cramps (HP:0003710)1.83240713
85Capillary hemangiomas (HP:0005306)1.82483484
86Subacute progressive viral hepatitis (HP:0006572)1.82111612
87Embryonal neoplasm (HP:0002898)1.81923806
88Neoplasm of the colon (HP:0100273)1.81762796
89Duplication of thumb phalanx (HP:0009942)1.81457110
90Entropion (HP:0000621)1.79681450
91Abnormality of the shoulder girdle musculature (HP:0001435)1.79093403
92Uterine neoplasm (HP:0010784)1.77933655
93Thyroid carcinoma (HP:0002890)1.77739744
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.76709621
95Oligodactyly (hands) (HP:0001180)1.76649547
96Low anterior hairline (HP:0000294)1.76348362
97Aplasia/hypoplasia of the humerus (HP:0006507)1.76143178
98Shallow orbits (HP:0000586)1.75488818
99Absent eyebrow (HP:0002223)1.75342420
100Abnormality of the preputium (HP:0100587)1.74032381
101Ulnar bowing (HP:0003031)1.73431405
102Abnormality of the lower motor neuron (HP:0002366)1.73179053
103Abnormality of the columella (HP:0009929)1.72858979
104Amyotrophic lateral sclerosis (HP:0007354)1.72680629
105Ovarian neoplasm (HP:0100615)1.72631839
106Abnormality of the calcaneus (HP:0008364)1.72184761
107Atrophy/Degeneration involving motor neurons (HP:0007373)1.72110207
108Neoplasm of the rectum (HP:0100743)1.72011176
109Oligodactyly (HP:0012165)1.71857563
110Pseudobulbar signs (HP:0002200)1.69867904
111Delayed puberty (HP:0000823)1.67517672
112Right ventricular cardiomyopathy (HP:0011663)1.67500857
113Carpal bone hypoplasia (HP:0001498)1.67487038
114Obsessive-compulsive behavior (HP:0000722)1.66737662
115Overlapping toe (HP:0001845)1.66649240
116Abnormality of the 4th metacarpal (HP:0010012)1.66284264
117Papillary thyroid carcinoma (HP:0002895)1.66243648
118Angiofibromas (HP:0010615)1.65543293
119Adenoma sebaceum (HP:0009720)1.65543293
120Termporal pattern (HP:0011008)1.65123624
121Insidious onset (HP:0003587)1.65123624
122Skull defect (HP:0001362)1.64768507
123Atresia of the external auditory canal (HP:0000413)1.64239968
124Abnormality of the carotid arteries (HP:0005344)1.64206643
125Urethral obstruction (HP:0000796)1.63973246
126Duodenal stenosis (HP:0100867)1.63635680
127Small intestinal stenosis (HP:0012848)1.63635680
128Freckling (HP:0001480)1.63203681
129Microvesicular hepatic steatosis (HP:0001414)1.62115835
130Broad alveolar ridges (HP:0000187)1.62103069
131Deep philtrum (HP:0002002)1.61822252
132Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.59723605
133Choanal atresia (HP:0000453)1.56840722
134Cutaneous syndactyly (HP:0012725)1.54164576
135Curly hair (HP:0002212)1.53546951
136Vertebral arch anomaly (HP:0008438)1.52031218
137Partial agenesis of the corpus callosum (HP:0001338)1.51902719
138Microglossia (HP:0000171)1.51648791
139Neoplasm of the adrenal cortex (HP:0100641)1.51502141
140Long clavicles (HP:0000890)1.51387017
141Arteriovenous malformation (HP:0100026)1.49676870
142Cutaneous finger syndactyly (HP:0010554)1.49345485
143Triphalangeal thumb (HP:0001199)1.49314327
144Progressive muscle weakness (HP:0003323)1.49067891
145Hypospadias (HP:0000047)1.48278004
146Septate vagina (HP:0001153)1.46454398
147Hypoplastic labia majora (HP:0000059)1.46299930
148Broad nasal tip (HP:0000455)1.43823180
149Median cleft lip (HP:0000161)1.43692826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.31789335
2CDK123.93386404
3WEE13.31162681
4NEK23.04430749
5PBK2.79884428
6ACVR1B2.44506946
7STK38L2.29697721
8SCYL22.27831017
9TRIM282.17212967
10BUB12.12856966
11TSSK62.08181742
12TTK2.00007089
13NEK11.98717116
14EEF2K1.96673410
15PKN21.88803492
16MAP2K71.85060964
17MAP3K101.80915531
18BRSK21.74952817
19MAP3K41.72273634
20OBSCN1.71745527
21STK101.67689580
22FLT31.67451793
23MELK1.66556262
24EIF2AK11.66500426
25TLK11.65699331
26PLK11.63407582
27TAF11.59355829
28RPS6KB21.59013942
29BRD41.58540777
30SRPK11.57513605
31PASK1.57269169
32ATR1.56330943
33PLK31.52618039
34CHEK11.51475583
35PINK11.50638636
36STK241.48849778
37AURKB1.46190108
38EPHA21.43432299
39CAMK1G1.43027303
40MAP3K91.38938506
41LATS11.37491443
42CHEK21.34914954
43CDK41.34105402
44BCR1.33623147
45STK31.32429462
46ALK1.30891553
47MAP3K81.30205851
48CDK71.29324858
49EIF2AK31.25495196
50RPS6KA41.23072518
51DYRK31.22208096
52STK41.19671135
53ATM1.18605186
54MTOR1.14662010
55PDGFRA1.12713988
56PNCK1.06741065
57CDK61.04995722
58FGFR21.03633172
59MAP4K11.02901683
60CDK21.02740958
61KSR11.01061240
62BRAF0.99872649
63TTN0.95976861
64MKNK10.94038375
65CASK0.92773935
66CAMK1D0.91726878
67AKT30.91366546
68CSNK1G30.87163362
69CDK30.85787681
70PIM10.84845221
71PLK40.81820883
72ERBB40.80350841
73PDK30.79239013
74PDK40.79239013
75CDK10.78407739
76FGFR10.76324895
77CSNK1G20.76022395
78TGFBR10.75947483
79FGFR30.74583349
80RPS6KB10.74567117
81ICK0.73958906
82NUAK10.72383062
83CCNB10.70540389
84PDGFRB0.70260279
85ZAK0.69061846
86TRIB30.68975808
87CSNK1D0.68227718
88TESK20.68004908
89MKNK20.67976856
90MET0.67259095
91BRSK10.65602002
92EIF2AK20.65370140
93CDK90.64368810
94STK160.64358321
95MAP4K20.63325409
96FRK0.62553065
97PRKDC0.61902062
98CSNK1E0.61822146
99PAK20.61404509
100PTK60.59965936
101AURKA0.58550072
102WNK30.55719816
103KSR20.54489745
104STK390.53707436
105LRRK20.52036236
106CSNK2A20.51738798
107MARK30.51634415
108NME10.51553311
109NEK60.50873995
110RET0.50733906
111NLK0.50359864
112JAK30.50282779
113MAPK140.48249561
114ITK0.47723392
115MST1R0.47455427
116PLK20.47204207
117FGFR40.46821110
118TYRO30.46460114
119AKT20.46155396
120ARAF0.46147722
121RPS6KA50.45490706
122LATS20.45475375
123TNIK0.45119899
124VRK10.43333286
125CSF1R0.42516380
126CHUK0.41971080
127CSNK1A1L0.38107047
128ERBB30.38026403
129GRK60.37453955
130GSK3B0.35998206
131CSNK1G10.34056512
132PDK20.33673551
133MAPK100.33119123
134MAPK10.32643765
135AKT10.31108445
136PRKCI0.30212501
137PAK40.30159664
138RAF10.29771606

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.61620315
2RNA transport_Homo sapiens_hsa030133.18377254
3Mismatch repair_Homo sapiens_hsa034303.17763609
4DNA replication_Homo sapiens_hsa030303.12698317
5Cell cycle_Homo sapiens_hsa041102.86605007
6Spliceosome_Homo sapiens_hsa030402.57795279
7One carbon pool by folate_Homo sapiens_hsa006702.40621261
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40151522
9mRNA surveillance pathway_Homo sapiens_hsa030152.27848550
10Systemic lupus erythematosus_Homo sapiens_hsa053222.17314070
11Homologous recombination_Homo sapiens_hsa034402.12597649
12RNA polymerase_Homo sapiens_hsa030202.05143459
13Non-homologous end-joining_Homo sapiens_hsa034501.98786456
14Nucleotide excision repair_Homo sapiens_hsa034201.94281432
15Fanconi anemia pathway_Homo sapiens_hsa034601.86002331
16Base excision repair_Homo sapiens_hsa034101.76798180
17p53 signaling pathway_Homo sapiens_hsa041151.71366450
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.68399147
19Viral carcinogenesis_Homo sapiens_hsa052031.63492639
20Antigen processing and presentation_Homo sapiens_hsa046121.60280901
21Propanoate metabolism_Homo sapiens_hsa006401.55740139
22RNA degradation_Homo sapiens_hsa030181.51392793
23Basal transcription factors_Homo sapiens_hsa030221.48167398
24MicroRNAs in cancer_Homo sapiens_hsa052061.44941824
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.44794471
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.44435684
27Oocyte meiosis_Homo sapiens_hsa041141.34611356
28mTOR signaling pathway_Homo sapiens_hsa041501.30760312
29Epstein-Barr virus infection_Homo sapiens_hsa051691.30397673
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27746629
31Small cell lung cancer_Homo sapiens_hsa052221.22443679
32Selenocompound metabolism_Homo sapiens_hsa004501.20625145
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14157178
34Pyruvate metabolism_Homo sapiens_hsa006201.13741097
35Colorectal cancer_Homo sapiens_hsa052101.12067108
36Pyrimidine metabolism_Homo sapiens_hsa002401.11331479
37HTLV-I infection_Homo sapiens_hsa051661.10632434
38Adherens junction_Homo sapiens_hsa045201.10104013
39Herpes simplex infection_Homo sapiens_hsa051681.09028313
40Chronic myeloid leukemia_Homo sapiens_hsa052201.08729480
41Alcoholism_Homo sapiens_hsa050341.06429268
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05004123
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03717074
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03328402
45Vitamin B6 metabolism_Homo sapiens_hsa007501.02793413
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01154720
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00228683
48Carbon metabolism_Homo sapiens_hsa012000.95537934
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95274376
50Hippo signaling pathway_Homo sapiens_hsa043900.93083137
51Dorso-ventral axis formation_Homo sapiens_hsa043200.90384497
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89819678
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89054425
54TGF-beta signaling pathway_Homo sapiens_hsa043500.88689605
55Lysine degradation_Homo sapiens_hsa003100.88675915
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87546987
57Pancreatic cancer_Homo sapiens_hsa052120.83456329
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.83370822
59Thyroid cancer_Homo sapiens_hsa052160.81813866
60Proteoglycans in cancer_Homo sapiens_hsa052050.78429681
61Prostate cancer_Homo sapiens_hsa052150.77778219
62Non-small cell lung cancer_Homo sapiens_hsa052230.77330983
63Steroid biosynthesis_Homo sapiens_hsa001000.77186614
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76143288
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.74396402
66Endometrial cancer_Homo sapiens_hsa052130.73298138
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72390073
68Hepatitis B_Homo sapiens_hsa051610.70400936
69FoxO signaling pathway_Homo sapiens_hsa040680.69532027
70Circadian rhythm_Homo sapiens_hsa047100.68729643
71Renal cell carcinoma_Homo sapiens_hsa052110.68117035
72T cell receptor signaling pathway_Homo sapiens_hsa046600.68098861
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66498579
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66495069
75Apoptosis_Homo sapiens_hsa042100.65223366
76Proteasome_Homo sapiens_hsa030500.63224428
77Basal cell carcinoma_Homo sapiens_hsa052170.62725990
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.62659229
79B cell receptor signaling pathway_Homo sapiens_hsa046620.61223938
80Pathways in cancer_Homo sapiens_hsa052000.60340734
81Viral myocarditis_Homo sapiens_hsa054160.60148195
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58962182
83Legionellosis_Homo sapiens_hsa051340.58831029
84Bladder cancer_Homo sapiens_hsa052190.58648850
85Notch signaling pathway_Homo sapiens_hsa043300.57251765
86Primary immunodeficiency_Homo sapiens_hsa053400.56759319
87Ribosome_Homo sapiens_hsa030100.56015436
88Measles_Homo sapiens_hsa051620.55831064
89Melanoma_Homo sapiens_hsa052180.55731983
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55047811
91Arginine biosynthesis_Homo sapiens_hsa002200.54833166
92HIF-1 signaling pathway_Homo sapiens_hsa040660.54815368
93Glioma_Homo sapiens_hsa052140.52184857
94Focal adhesion_Homo sapiens_hsa045100.51882630
95Acute myeloid leukemia_Homo sapiens_hsa052210.51747827
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51485539
97Tight junction_Homo sapiens_hsa045300.50975929
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50341038
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49971307
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.49517491
101Influenza A_Homo sapiens_hsa051640.49377358
102Purine metabolism_Homo sapiens_hsa002300.49152791
103Insulin signaling pathway_Homo sapiens_hsa049100.48735453
104Gap junction_Homo sapiens_hsa045400.48335075
105Pentose phosphate pathway_Homo sapiens_hsa000300.47774007
106Inositol phosphate metabolism_Homo sapiens_hsa005620.46713750
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46182521
108Glucagon signaling pathway_Homo sapiens_hsa049220.45325628
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44877484
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44873653
111Wnt signaling pathway_Homo sapiens_hsa043100.44799844
112Hedgehog signaling pathway_Homo sapiens_hsa043400.43194353
113ErbB signaling pathway_Homo sapiens_hsa040120.42965095
114Shigellosis_Homo sapiens_hsa051310.42948043
115Toxoplasmosis_Homo sapiens_hsa051450.42577100
116AMPK signaling pathway_Homo sapiens_hsa041520.42371959
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40372158
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39435261
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38271127
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37489584
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36058161
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35690458
123Fatty acid metabolism_Homo sapiens_hsa012120.35666951
124Prolactin signaling pathway_Homo sapiens_hsa049170.34990790
125Biosynthesis of amino acids_Homo sapiens_hsa012300.34957070
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34408795
127VEGF signaling pathway_Homo sapiens_hsa043700.33872483
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33275527
129Fatty acid biosynthesis_Homo sapiens_hsa000610.29831702
130N-Glycan biosynthesis_Homo sapiens_hsa005100.29251731
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28248082
132Choline metabolism in cancer_Homo sapiens_hsa052310.26763724
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26555183
134Dilated cardiomyopathy_Homo sapiens_hsa054140.25414504

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