PARGP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.00449040
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.56144208
3regulation of translation, ncRNA-mediated (GO:0045974)4.56144208
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.56144208
5neural tube formation (GO:0001841)4.18236695
6replication fork processing (GO:0031297)4.12935221
7establishment of protein localization to Golgi (GO:0072600)3.93540919
8imidazole-containing compound metabolic process (GO:0052803)3.70296141
9protein prenylation (GO:0018342)3.64639449
10prenylation (GO:0097354)3.64639449
11protein K11-linked deubiquitination (GO:0035871)3.61598996
12protein targeting to Golgi (GO:0000042)3.57989205
13histone mRNA catabolic process (GO:0071044)3.53409960
14regulation of hexokinase activity (GO:1903299)3.52678078
15regulation of glucokinase activity (GO:0033131)3.52678078
16centriole replication (GO:0007099)3.48522722
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.44838170
18regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.44611841
19epithelial cilium movement (GO:0003351)3.39345994
20regulation of acyl-CoA biosynthetic process (GO:0050812)3.37298959
21maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.37172770
22retrograde transport, vesicle recycling within Golgi (GO:0000301)3.32053197
23cytoplasmic mRNA processing body assembly (GO:0033962)3.23811609
24genitalia morphogenesis (GO:0035112)3.18714826
25resolution of meiotic recombination intermediates (GO:0000712)3.17427967
26rRNA catabolic process (GO:0016075)3.16775969
27positive regulation of glycolytic process (GO:0045821)3.11210354
28negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08984045
29intraciliary transport (GO:0042073)3.04772455
30male meiosis (GO:0007140)3.04343285
31regulation of phosphoprotein phosphatase activity (GO:0043666)3.03534193
32double-strand break repair via homologous recombination (GO:0000724)3.02961199
33histone H2A acetylation (GO:0043968)3.01534906
34cilium organization (GO:0044782)3.01165150
35centriole assembly (GO:0098534)3.00695032
36regulation of hippo signaling (GO:0035330)2.99938969
37cilium assembly (GO:0042384)2.98863581
38recombinational repair (GO:0000725)2.98852716
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98341240
40fucose catabolic process (GO:0019317)2.94771620
41L-fucose metabolic process (GO:0042354)2.94771620
42L-fucose catabolic process (GO:0042355)2.94771620
43microtubule anchoring (GO:0034453)2.93387723
44DNA integration (GO:0015074)2.91532786
45response to pheromone (GO:0019236)2.88009509
46regulation of cofactor metabolic process (GO:0051193)2.86647326
47regulation of coenzyme metabolic process (GO:0051196)2.86647326
48intra-S DNA damage checkpoint (GO:0031573)2.79112590
49cilium morphogenesis (GO:0060271)2.78624445
50monoubiquitinated protein deubiquitination (GO:0035520)2.77572361
51translesion synthesis (GO:0019985)2.76659797
52behavioral response to nicotine (GO:0035095)2.75544936
53DNA demethylation (GO:0080111)2.73855342
54cilium movement (GO:0003341)2.71216527
55protein localization to Golgi apparatus (GO:0034067)2.70373287
56sperm motility (GO:0030317)2.67772209
57positive regulation of developmental pigmentation (GO:0048087)2.67362325
58amino acid salvage (GO:0043102)2.67335772
59L-methionine salvage (GO:0071267)2.67335772
60L-methionine biosynthetic process (GO:0071265)2.67335772
61detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.66584764
62negative regulation of DNA recombination (GO:0045910)2.65616813
63ncRNA catabolic process (GO:0034661)2.64327015
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63080861
65atrial cardiac muscle cell action potential (GO:0086014)2.62000226
66limb bud formation (GO:0060174)2.60816135
67photoreceptor cell maintenance (GO:0045494)2.59478027
68nonmotile primary cilium assembly (GO:0035058)2.58714867
69multicellular organism reproduction (GO:0032504)2.58621429
70cellular component assembly involved in morphogenesis (GO:0010927)2.57964581
71methionine biosynthetic process (GO:0009086)2.57572004
72peptidyl-lysine trimethylation (GO:0018023)2.57162412
73acrosome reaction (GO:0007340)2.56507982
74protein polyglutamylation (GO:0018095)2.55831189
75synapsis (GO:0007129)2.55274404
76microtubule organizing center organization (GO:0031023)2.53772063
77centrosome duplication (GO:0051298)2.52508861
78mRNA cleavage (GO:0006379)2.52093044
79regulation of telomere maintenance (GO:0032204)2.51221918
80mitotic sister chromatid cohesion (GO:0007064)2.50248443
81DNA replication-dependent nucleosome organization (GO:0034723)2.50057317
82DNA replication-dependent nucleosome assembly (GO:0006335)2.50057317
83phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.49773493
84DNA catabolic process, exonucleolytic (GO:0000738)2.49688645
85axoneme assembly (GO:0035082)2.48604603
86presynaptic membrane assembly (GO:0097105)2.48582469
87regulation of sulfur metabolic process (GO:0042762)2.48281408
88DNA dealkylation (GO:0035510)2.48103679
89detection of light stimulus involved in sensory perception (GO:0050962)2.47103013
90detection of light stimulus involved in visual perception (GO:0050908)2.47103013
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46996636
92postreplication repair (GO:0006301)2.46345731
93negative regulation of mast cell activation (GO:0033004)2.45107396
94regulation of centrosome duplication (GO:0010824)2.43948145
95histone H3-K9 methylation (GO:0051567)2.43827472
96reciprocal meiotic recombination (GO:0007131)2.43419298
97reciprocal DNA recombination (GO:0035825)2.43419298
98centrosome organization (GO:0051297)2.42409782
99regulation of relaxation of muscle (GO:1901077)2.42100361
100cAMP catabolic process (GO:0006198)2.41919542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.47565047
2IGF1R_20145208_ChIP-Seq_DFB_Human3.36211517
3GBX2_23144817_ChIP-Seq_PC3_Human3.33247550
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.90577838
5ZNF274_21170338_ChIP-Seq_K562_Hela2.79835118
6FUS_26573619_Chip-Seq_HEK293_Human2.71370964
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.69988738
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68939450
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.60600673
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.59813221
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51200129
12VDR_22108803_ChIP-Seq_LS180_Human2.50268587
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14857983
14EWS_26573619_Chip-Seq_HEK293_Human2.12214428
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11781100
16P300_19829295_ChIP-Seq_ESCs_Human2.09215373
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08935695
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98998543
19ER_23166858_ChIP-Seq_MCF-7_Human1.98345967
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97643183
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95885805
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90111029
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.86514576
24TAF15_26573619_Chip-Seq_HEK293_Human1.77624732
25SMAD4_21799915_ChIP-Seq_A2780_Human1.77285358
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72418351
27STAT3_23295773_ChIP-Seq_U87_Human1.72259259
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65896356
29CBP_20019798_ChIP-Seq_JUKART_Human1.65896356
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60386032
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59347099
32BCAT_22108803_ChIP-Seq_LS180_Human1.56978930
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56602025
34TCF4_23295773_ChIP-Seq_U87_Human1.55419551
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53618093
36AR_21572438_ChIP-Seq_LNCaP_Human1.50311136
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.50238482
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.48618991
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48346761
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48162347
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.47134307
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44171615
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44171615
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42423550
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42095353
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39449264
47AR_25329375_ChIP-Seq_VCAP_Human1.37429558
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37318435
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35749921
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35525100
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.35303443
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32341941
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30283629
54IRF1_19129219_ChIP-ChIP_H3396_Human1.28015214
55RUNX2_22187159_ChIP-Seq_PCA_Human1.26195882
56ELK1_19687146_ChIP-ChIP_HELA_Human1.25043719
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23489137
58E2F7_22180533_ChIP-Seq_HELA_Human1.22987621
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21920915
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.20998756
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18641672
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.18579004
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18211404
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18165262
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17890623
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17572482
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16229098
68TCF4_22108803_ChIP-Seq_LS180_Human1.15279513
69GATA1_22025678_ChIP-Seq_K562_Human1.14780775
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13968073
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13926751
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.13159816
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11765713
74TP53_22573176_ChIP-Seq_HFKS_Human1.11531066
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.10809883
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.09957169
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07548957
78CDX2_22108803_ChIP-Seq_LS180_Human1.07154460
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05776668
80WDR5_24793694_ChIP-Seq_LNCAP_Human1.04566193
81RXR_22108803_ChIP-Seq_LS180_Human1.04306056
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.04115444
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.03858930
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03151491
85P53_22387025_ChIP-Seq_ESCs_Mouse1.02258067
86TBL1_22424771_ChIP-Seq_293T_Human1.01369543
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01361819
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.00752031
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00391581
90SOX2_19829295_ChIP-Seq_ESCs_Human1.00321728
91NANOG_19829295_ChIP-Seq_ESCs_Human1.00321728
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.99415247
93TP53_16413492_ChIP-PET_HCT116_Human0.98976236
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97255385
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97144730
96AHR_22903824_ChIP-Seq_MCF-7_Human0.96704186
97MYC_18940864_ChIP-ChIP_HL60_Human0.95522941
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.95354590
99P300_18555785_Chip-Seq_ESCs_Mouse0.94567612
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94254846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.36197449
2MP0008057_abnormal_DNA_replication2.96918123
3MP0002102_abnormal_ear_morphology2.88832720
4MP0001984_abnormal_olfaction2.81811475
5MP0008058_abnormal_DNA_repair2.78088975
6MP0008877_abnormal_DNA_methylation2.63355410
7MP0003787_abnormal_imprinting2.53696967
8MP0009697_abnormal_copulation2.45222097
9MP0010094_abnormal_chromosome_stability2.24407705
10MP0003646_muscle_fatigue2.17856611
11MP0005253_abnormal_eye_physiology2.15371300
12MP0009046_muscle_twitch2.02862560
13MP0006072_abnormal_retinal_apoptosis2.02196273
14MP0002735_abnormal_chemical_nociception1.93654636
15MP0005187_abnormal_penis_morphology1.83934576
16MP0000372_irregular_coat_pigmentation1.77179608
17MP0005551_abnormal_eye_electrophysiolog1.74292144
18MP0005410_abnormal_fertilization1.70084232
19MP0005394_taste/olfaction_phenotype1.68219196
20MP0005499_abnormal_olfactory_system1.68219196
21MP0005075_abnormal_melanosome_morpholog1.65942244
22MP0003890_abnormal_embryonic-extraembry1.61784430
23MP0002160_abnormal_reproductive_system1.59358459
24MP0004484_altered_response_of1.56663070
25MP0008995_early_reproductive_senescence1.52546215
26MP0001929_abnormal_gametogenesis1.48544942
27MP0002837_dystrophic_cardiac_calcinosis1.48481993
28MP0003195_calcinosis1.48346540
29MP0002638_abnormal_pupillary_reflex1.47442110
30MP0000749_muscle_degeneration1.46979095
31MP0003698_abnormal_male_reproductive1.42717047
32MP0003221_abnormal_cardiomyocyte_apopto1.40901159
33MP0003693_abnormal_embryo_hatching1.38830244
34MP0003121_genomic_imprinting1.34925222
35MP0005646_abnormal_pituitary_gland1.34212609
36MP0002009_preneoplasia1.33903459
37MP0005174_abnormal_tail_pigmentation1.31609063
38MP0004084_abnormal_cardiac_muscle1.30837478
39MP0008789_abnormal_olfactory_epithelium1.30422068
40MP0002751_abnormal_autonomic_nervous1.25720291
41MP0003136_yellow_coat_color1.25667838
42MP0003718_maternal_effect1.25423001
43MP0000631_abnormal_neuroendocrine_gland1.24954944
44MP0006276_abnormal_autonomic_nervous1.20838502
45MP0000427_abnormal_hair_cycle1.19804880
46MP0002127_abnormal_cardiovascular_syste1.19501491
47MP0001529_abnormal_vocalization1.18741817
48MP0001968_abnormal_touch/_nociception1.16895500
49MP0002233_abnormal_nose_morphology1.16780867
50MP0004145_abnormal_muscle_electrophysio1.16242948
51MP0005391_vision/eye_phenotype1.15978701
52MP0005171_absent_coat_pigmentation1.08033623
53MP0002736_abnormal_nociception_after1.07262161
54MP0002210_abnormal_sex_determination1.03422337
55MP0005248_abnormal_Harderian_gland1.02002626
56MP0005647_abnormal_sex_gland1.01971444
57MP0003315_abnormal_perineum_morphology1.01534182
58MP0005389_reproductive_system_phenotype0.99738770
59MP0003283_abnormal_digestive_organ0.99727782
60MP0000653_abnormal_sex_gland0.98746568
61MP0001145_abnormal_male_reproductive0.98107366
62MP0001486_abnormal_startle_reflex0.97583889
63MP0002272_abnormal_nervous_system0.96078254
64MP0004215_abnormal_myocardial_fiber0.94981471
65MP0003937_abnormal_limbs/digits/tail_de0.94979312
66MP0003077_abnormal_cell_cycle0.94436031
67MP0004134_abnormal_chest_morphology0.93733311
68MP0000383_abnormal_hair_follicle0.93306787
69MP0002108_abnormal_muscle_morphology0.89875856
70MP0008872_abnormal_physiological_respon0.89050498
71MP0006292_abnormal_olfactory_placode0.88951650
72MP0003786_premature_aging0.85485253
73MP0002184_abnormal_innervation0.84640760
74MP0003950_abnormal_plasma_membrane0.83743573
75MP0002938_white_spotting0.82615478
76MP0003567_abnormal_fetal_cardiomyocyte0.81933283
77MP0005645_abnormal_hypothalamus_physiol0.81725024
78MP0004924_abnormal_behavior0.81271684
79MP0005386_behavior/neurological_phenoty0.81271684
80MP0005620_abnormal_muscle_contractility0.80255373
81MP0002067_abnormal_sensory_capabilities0.79489156
82MP0004036_abnormal_muscle_relaxation0.78256680
83MP0003111_abnormal_nucleus_morphology0.78024308
84MP0002095_abnormal_skin_pigmentation0.77038485
85MP0000015_abnormal_ear_pigmentation0.76755123
86MP0000778_abnormal_nervous_system0.75990715
87MP0002752_abnormal_somatic_nervous0.75833637
88MP0004085_abnormal_heartbeat0.75438480
89MP0001324_abnormal_eye_pigmentation0.74920945
90MP0000371_diluted_coat_color0.74835639
91MP0004133_heterotaxia0.74274270
92MP0010678_abnormal_skin_adnexa0.73765045
93MP0000516_abnormal_urinary_system0.73743366
94MP0005367_renal/urinary_system_phenotyp0.73743366
95MP0002269_muscular_atrophy0.73701240
96MP0004043_abnormal_pH_regulation0.72009825
97MP0009745_abnormal_behavioral_response0.71944454
98MP0001485_abnormal_pinna_reflex0.70588743
99MP0000647_abnormal_sebaceous_gland0.70459131
100MP0009115_abnormal_fat_cell0.70158109

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.82847116
2Chronic hepatic failure (HP:0100626)3.59954364
3Hyperventilation (HP:0002883)3.57536806
4Pancreatic fibrosis (HP:0100732)3.55383275
5True hermaphroditism (HP:0010459)3.49218713
6Volvulus (HP:0002580)3.00699054
7Aplasia/Hypoplasia of the uvula (HP:0010293)2.96378702
8Abnormality of midbrain morphology (HP:0002418)2.82766294
9Molar tooth sign on MRI (HP:0002419)2.82766294
10Chromsome breakage (HP:0040012)2.80345105
11Abnormality of the renal cortex (HP:0011035)2.76114269
12Intestinal atresia (HP:0011100)2.75896453
13Gaze-evoked nystagmus (HP:0000640)2.70137650
14Abnormality of chromosome stability (HP:0003220)2.68056386
15Nephronophthisis (HP:0000090)2.65840031
16Abnormal biliary tract physiology (HP:0012439)2.65510608
17Bile duct proliferation (HP:0001408)2.65510608
18Renal cortical cysts (HP:0000803)2.63934063
19Type II lissencephaly (HP:0007260)2.59815476
20Tubulointerstitial nephritis (HP:0001970)2.57686106
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57627934
22Cerebellar dysplasia (HP:0007033)2.56426271
23Abnormality of the ileum (HP:0001549)2.53914518
24Hypothermia (HP:0002045)2.53156499
25Medial flaring of the eyebrow (HP:0010747)2.51456392
26Cystic liver disease (HP:0006706)2.50075095
27Inability to walk (HP:0002540)2.42617652
28Abnormality of the renal medulla (HP:0100957)2.41776691
29Thyroiditis (HP:0100646)2.34269040
30Protruding tongue (HP:0010808)2.33350964
31Long clavicles (HP:0000890)2.32995217
32Abnormality of the labia minora (HP:0012880)2.30354782
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.29966223
34Meckel diverticulum (HP:0002245)2.29897817
35Febrile seizures (HP:0002373)2.23911048
36Absent speech (HP:0001344)2.23017257
37Sloping forehead (HP:0000340)2.22584170
38Duplicated collecting system (HP:0000081)2.19147073
39Congenital primary aphakia (HP:0007707)2.18130556
40Calf muscle hypertrophy (HP:0008981)2.17811636
41Birth length less than 3rd percentile (HP:0003561)2.16720311
42Progressive cerebellar ataxia (HP:0002073)2.15874398
43Genital tract atresia (HP:0001827)2.13153719
44Small hand (HP:0200055)2.12923063
45Abnormality of the renal collecting system (HP:0004742)2.12913222
46Clubbing of toes (HP:0100760)2.12428614
47Gait imbalance (HP:0002141)2.10211331
48Abnormality of the pons (HP:0007361)2.09827839
49Progressive inability to walk (HP:0002505)2.09361518
50Neoplasm of the adrenal cortex (HP:0100641)2.09293943
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.09004744
52Nephrogenic diabetes insipidus (HP:0009806)2.07187924
53Hepatoblastoma (HP:0002884)2.05209970
54Poor coordination (HP:0002370)2.04828197
55Widely spaced teeth (HP:0000687)2.02166648
56Postaxial foot polydactyly (HP:0001830)2.00029616
57Broad-based gait (HP:0002136)1.98724553
58Vaginal atresia (HP:0000148)1.97506226
59Male pseudohermaphroditism (HP:0000037)1.96448502
60Cupped ear (HP:0000378)1.96440648
61Abnormality of the preputium (HP:0100587)1.95079690
62Anencephaly (HP:0002323)1.93007785
63Fair hair (HP:0002286)1.92811982
64Ectopic kidney (HP:0000086)1.92333439
65Lissencephaly (HP:0001339)1.91053640
66Atonic seizures (HP:0010819)1.88389844
67Oligodactyly (hands) (HP:0001180)1.87646774
68Astigmatism (HP:0000483)1.86099263
69Drooling (HP:0002307)1.85159663
70Muscle hypertrophy of the lower extremities (HP:0008968)1.83585702
71Attenuation of retinal blood vessels (HP:0007843)1.82642653
72Hypoplasia of the pons (HP:0012110)1.81888584
73Pancreatic islet-cell hyperplasia (HP:0004510)1.80780204
74Gastrointestinal atresia (HP:0002589)1.80388347
75Decreased lacrimation (HP:0000633)1.80226948
76Papillary thyroid carcinoma (HP:0002895)1.80172403
77Abnormality of the columella (HP:0009929)1.79788784
78Congenital stationary night blindness (HP:0007642)1.79656094
79Sensory axonal neuropathy (HP:0003390)1.79250859
80Dyskinesia (HP:0100660)1.78631286
81Hypoplastic labia majora (HP:0000059)1.78175561
82Congenital hepatic fibrosis (HP:0002612)1.77866941
83Postaxial hand polydactyly (HP:0001162)1.77835149
84Large for gestational age (HP:0001520)1.76833095
85Stomach cancer (HP:0012126)1.74795958
86Truncal obesity (HP:0001956)1.73217632
87Occipital encephalocele (HP:0002085)1.72930230
88Preaxial hand polydactyly (HP:0001177)1.72604275
89Abnormality of DNA repair (HP:0003254)1.71056932
90Furrowed tongue (HP:0000221)1.69326560
91Neoplasm of the oral cavity (HP:0100649)1.64683010
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.64307492
93Tented upper lip vermilion (HP:0010804)1.64018263
94Retinal dysplasia (HP:0007973)1.63296113
95Rimmed vacuoles (HP:0003805)1.63081047
96Excessive salivation (HP:0003781)1.62934029
97Abnormality of the astrocytes (HP:0100707)1.62124186
98Astrocytoma (HP:0009592)1.62124186
99Abnormality of the labia majora (HP:0012881)1.61981444
100Abnormality of the duodenum (HP:0002246)1.61911714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.74332554
2PINK13.57124636
3TRIM283.30970169
4MAP4K23.02682215
5MAP2K72.75801567
6MAP3K42.65742416
7BMPR1B2.60288718
8OBSCN2.43082660
9MARK32.41295606
10ZAK2.14765470
11TNIK2.12810251
12WNK32.01066178
13ACVR1B1.93542762
14EIF2AK31.83905294
15STK38L1.77140839
16CSNK1A1L1.74836763
17CSNK1G11.73486156
18LATS11.65682302
19CASK1.54457029
20CSNK1G31.47982260
21AKT31.44985907
22MAPK131.41407479
23NUAK11.39380376
24FGFR21.37624946
25INSRR1.28733155
26NEK21.26833387
27CSNK1G21.25492603
28ERBB31.25087704
29GRK11.24374415
30SRPK11.20453305
31BCR1.20379827
32ADRBK21.20372441
33STK391.19870615
34MKNK21.18655104
35CCNB11.14562427
36NLK1.14366905
37TLK11.13751353
38BRD41.12815673
39PAK31.09718691
40SGK21.09094199
41BRSK21.05847015
42PLK41.03882157
43CDK31.00213433
44TGFBR10.89717384
45CDC70.88755136
46ATM0.81229981
47CAMK1G0.78233139
48DYRK30.76547366
49SGK4940.75921617
50SGK2230.75921617
51WNK40.75044800
52ATR0.74190840
53MKNK10.73561970
54PLK20.73358289
55RPS6KB10.70523921
56EPHA40.69701606
57VRK10.64632097
58PLK10.62994736
59NEK10.61672455
60RPS6KA50.61519686
61MAP2K40.60164045
62OXSR10.59599831
63PTK2B0.57422879
64STK30.54679224
65FER0.53217091
66CSNK1D0.52736622
67WEE10.49241394
68PNCK0.48789029
69PLK30.48285081
70RPS6KA40.47653003
71TEC0.46917449
72PRKAA10.44640131
73WNK10.43850892
74PRKCQ0.43741603
75PRKCE0.43176388
76CSNK1A10.42671863
77CAMK1D0.42255543
78TRPM70.40740214
79SGK30.39976907
80KSR10.39564797
81PIK3CG0.38624000
82CAMK40.37266706
83CHEK10.37115757
84MARK10.36421936
85PRKACB0.36124423
86MELK0.35062730
87MST40.34205435
88PKN10.33907044
89EGFR0.33407891
90TXK0.32169722
91AURKB0.31246865
92DAPK20.30190921
93NTRK20.29603393
94CAMKK20.29177893
95PIK3CA0.28741344
96ADRBK10.28534966
97PHKG20.27715954
98PHKG10.27715954
99PIM10.27674540
100PRKG10.26987070

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.37222371
2Non-homologous end-joining_Homo sapiens_hsa034502.82332591
3Homologous recombination_Homo sapiens_hsa034402.81891029
4Olfactory transduction_Homo sapiens_hsa047402.73088503
5Phototransduction_Homo sapiens_hsa047442.71377832
6Butanoate metabolism_Homo sapiens_hsa006502.47306119
7Basal transcription factors_Homo sapiens_hsa030222.45716991
8Nitrogen metabolism_Homo sapiens_hsa009102.26684442
9Propanoate metabolism_Homo sapiens_hsa006402.15016747
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02769674
11RNA degradation_Homo sapiens_hsa030181.99055388
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85026593
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.76526304
14Circadian rhythm_Homo sapiens_hsa047101.64453281
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63745977
16Taste transduction_Homo sapiens_hsa047421.55755208
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51019047
18Regulation of autophagy_Homo sapiens_hsa041401.43355633
19Oocyte meiosis_Homo sapiens_hsa041141.39793067
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39666619
21Protein export_Homo sapiens_hsa030601.38190197
22Nicotine addiction_Homo sapiens_hsa050331.36029928
23Mismatch repair_Homo sapiens_hsa034301.33749258
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32148716
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32080649
26Nucleotide excision repair_Homo sapiens_hsa034201.31262643
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30678047
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28829363
29Histidine metabolism_Homo sapiens_hsa003401.24797589
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22539865
31RNA transport_Homo sapiens_hsa030131.22169077
32Selenocompound metabolism_Homo sapiens_hsa004501.21627006
33Systemic lupus erythematosus_Homo sapiens_hsa053221.16048020
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11952971
35Lysine degradation_Homo sapiens_hsa003101.08933508
36Hedgehog signaling pathway_Homo sapiens_hsa043401.07619987
37Caffeine metabolism_Homo sapiens_hsa002321.06671976
38Alcoholism_Homo sapiens_hsa050341.05782214
39mRNA surveillance pathway_Homo sapiens_hsa030151.04225402
40ABC transporters_Homo sapiens_hsa020101.02324858
41TGF-beta signaling pathway_Homo sapiens_hsa043500.99563306
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.99268561
43Peroxisome_Homo sapiens_hsa041460.95581573
44Circadian entrainment_Homo sapiens_hsa047130.94690160
45Salivary secretion_Homo sapiens_hsa049700.94385489
46Dorso-ventral axis formation_Homo sapiens_hsa043200.93983608
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.92730104
48Linoleic acid metabolism_Homo sapiens_hsa005910.88546874
49DNA replication_Homo sapiens_hsa030300.87036688
50Calcium signaling pathway_Homo sapiens_hsa040200.86359372
51Purine metabolism_Homo sapiens_hsa002300.84932538
52FoxO signaling pathway_Homo sapiens_hsa040680.81270509
53Chemical carcinogenesis_Homo sapiens_hsa052040.81156237
54Cell cycle_Homo sapiens_hsa041100.79261175
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76682170
56Ether lipid metabolism_Homo sapiens_hsa005650.73366445
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.72717152
58Oxytocin signaling pathway_Homo sapiens_hsa049210.71832504
59GABAergic synapse_Homo sapiens_hsa047270.71645717
60Renin secretion_Homo sapiens_hsa049240.70503901
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70190426
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69369458
63Dopaminergic synapse_Homo sapiens_hsa047280.68713810
64Morphine addiction_Homo sapiens_hsa050320.67225099
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67146728
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.66554748
67beta-Alanine metabolism_Homo sapiens_hsa004100.65819017
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62573429
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62214315
70p53 signaling pathway_Homo sapiens_hsa041150.60547303
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58883196
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57971451
73Spliceosome_Homo sapiens_hsa030400.57191064
74Glucagon signaling pathway_Homo sapiens_hsa049220.56692826
75Glycerolipid metabolism_Homo sapiens_hsa005610.55155438
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55090500
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54538138
78Insulin secretion_Homo sapiens_hsa049110.54112402
79Amphetamine addiction_Homo sapiens_hsa050310.53390959
80cAMP signaling pathway_Homo sapiens_hsa040240.50791617
81Wnt signaling pathway_Homo sapiens_hsa043100.49073980
82Primary immunodeficiency_Homo sapiens_hsa053400.48440346
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47935357
84One carbon pool by folate_Homo sapiens_hsa006700.47469700
85Retinol metabolism_Homo sapiens_hsa008300.47016935
86Renin-angiotensin system_Homo sapiens_hsa046140.46273568
87Inositol phosphate metabolism_Homo sapiens_hsa005620.45992132
88Glutamatergic synapse_Homo sapiens_hsa047240.44526154
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44123975
90Long-term depression_Homo sapiens_hsa047300.44108843
91RNA polymerase_Homo sapiens_hsa030200.43749239
92Tryptophan metabolism_Homo sapiens_hsa003800.43660787
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42969969
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42907005
95Melanoma_Homo sapiens_hsa052180.41785002
96Asthma_Homo sapiens_hsa053100.41043459
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.40554785
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39938150
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.38767551
100Ovarian steroidogenesis_Homo sapiens_hsa049130.38472659

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