ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.00449040
2	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.56144208
3	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.56144208
4	regulation of translation, ncRNA-mediated (GO:0045974)	4.56144208
5	neural tube formation (GO:0001841)	4.18236695
6	replication fork processing (GO:0031297)	4.12935221
7	establishment of protein localization to Golgi (GO:0072600)	3.93540919
8	imidazole-containing compound metabolic process (GO:0052803)	3.70296141
9	prenylation (GO:0097354)	3.64639449
10	protein prenylation (GO:0018342)	3.64639449
11	protein K11-linked deubiquitination (GO:0035871)	3.61598996
12	protein targeting to Golgi (GO:0000042)	3.57989205
13	histone mRNA catabolic process (GO:0071044)	3.53409960
14	regulation of hexokinase activity (GO:1903299)	3.52678078
15	regulation of glucokinase activity (GO:0033131)	3.52678078
16	centriole replication (GO:0007099)	3.48522722
17	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.44838170
18	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.44611841
19	epithelial cilium movement (GO:0003351)	3.39345994
20	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.37298959
21	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.37172770
22	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.32053197
23	cytoplasmic mRNA processing body assembly (GO:0033962)	3.23811609
24	genitalia morphogenesis (GO:0035112)	3.18714826
25	resolution of meiotic recombination intermediates (GO:0000712)	3.17427967
26	rRNA catabolic process (GO:0016075)	3.16775969
27	positive regulation of glycolytic process (GO:0045821)	3.11210354
28	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.08984045
29	intraciliary transport (GO:0042073)	3.04772455
30	male meiosis (GO:0007140)	3.04343285
31	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.03534193
32	double-strand break repair via homologous recombination (GO:0000724)	3.02961199
33	histone H2A acetylation (GO:0043968)	3.01534906
34	cilium organization (GO:0044782)	3.01165150
35	centriole assembly (GO:0098534)	3.00695032
36	regulation of hippo signaling (GO:0035330)	2.99938969
37	cilium assembly (GO:0042384)	2.98863581
38	recombinational repair (GO:0000725)	2.98852716
39	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.98341240
40	L-fucose catabolic process (GO:0042355)	2.94771620
41	fucose catabolic process (GO:0019317)	2.94771620
42	L-fucose metabolic process (GO:0042354)	2.94771620
43	microtubule anchoring (GO:0034453)	2.93387723
44	DNA integration (GO:0015074)	2.91532786
45	response to pheromone (GO:0019236)	2.88009509
46	regulation of cofactor metabolic process (GO:0051193)	2.86647326
47	regulation of coenzyme metabolic process (GO:0051196)	2.86647326
48	intra-S DNA damage checkpoint (GO:0031573)	2.79112590
49	cilium morphogenesis (GO:0060271)	2.78624445
50	monoubiquitinated protein deubiquitination (GO:0035520)	2.77572361
51	translesion synthesis (GO:0019985)	2.76659797
52	behavioral response to nicotine (GO:0035095)	2.75544936
53	DNA demethylation (GO:0080111)	2.73855342
54	cilium movement (GO:0003341)	2.71216527
55	protein localization to Golgi apparatus (GO:0034067)	2.70373287
56	sperm motility (GO:0030317)	2.67772209
57	positive regulation of developmental pigmentation (GO:0048087)	2.67362325
58	L-methionine salvage (GO:0071267)	2.67335772
59	L-methionine biosynthetic process (GO:0071265)	2.67335772
60	amino acid salvage (GO:0043102)	2.67335772
61	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.66584764
62	negative regulation of DNA recombination (GO:0045910)	2.65616813
63	ncRNA catabolic process (GO:0034661)	2.64327015
64	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.63080861
65	atrial cardiac muscle cell action potential (GO:0086014)	2.62000226
66	limb bud formation (GO:0060174)	2.60816135
67	photoreceptor cell maintenance (GO:0045494)	2.59478027
68	nonmotile primary cilium assembly (GO:0035058)	2.58714867
69	multicellular organism reproduction (GO:0032504)	2.58621429
70	cellular component assembly involved in morphogenesis (GO:0010927)	2.57964581
71	methionine biosynthetic process (GO:0009086)	2.57572004
72	peptidyl-lysine trimethylation (GO:0018023)	2.57162412
73	acrosome reaction (GO:0007340)	2.56507982
74	protein polyglutamylation (GO:0018095)	2.55831189
75	synapsis (GO:0007129)	2.55274404
76	microtubule organizing center organization (GO:0031023)	2.53772063
77	centrosome duplication (GO:0051298)	2.52508861
78	mRNA cleavage (GO:0006379)	2.52093044
79	regulation of telomere maintenance (GO:0032204)	2.51221918
80	mitotic sister chromatid cohesion (GO:0007064)	2.50248443
81	DNA replication-dependent nucleosome organization (GO:0034723)	2.50057317
82	DNA replication-dependent nucleosome assembly (GO:0006335)	2.50057317
83	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.49773493
84	DNA catabolic process, exonucleolytic (GO:0000738)	2.49688645
85	axoneme assembly (GO:0035082)	2.48604603
86	presynaptic membrane assembly (GO:0097105)	2.48582469
87	regulation of sulfur metabolic process (GO:0042762)	2.48281408
88	DNA dealkylation (GO:0035510)	2.48103679
89	detection of light stimulus involved in visual perception (GO:0050908)	2.47103013
90	detection of light stimulus involved in sensory perception (GO:0050962)	2.47103013
91	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.46996636
92	postreplication repair (GO:0006301)	2.46345731
93	negative regulation of mast cell activation (GO:0033004)	2.45107396
94	regulation of centrosome duplication (GO:0010824)	2.43948145
95	histone H3-K9 methylation (GO:0051567)	2.43827472
96	reciprocal meiotic recombination (GO:0007131)	2.43419298
97	reciprocal DNA recombination (GO:0035825)	2.43419298
98	centrosome organization (GO:0051297)	2.42409782
99	regulation of relaxation of muscle (GO:1901077)	2.42100361
100	cAMP catabolic process (GO:0006198)	2.41919542

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.47565047
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.36211517
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.33247550
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.90577838
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79835118
6	FUS_26573619_Chip-Seq_HEK293_Human	2.71370964
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.69988738
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.68939450
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.60600673
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.59813221
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51200129
12	VDR_22108803_ChIP-Seq_LS180_Human	2.50268587
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.14857983
14	EWS_26573619_Chip-Seq_HEK293_Human	2.12214428
15	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.11781100
16	P300_19829295_ChIP-Seq_ESCs_Human	2.09215373
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08935695
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.98998543
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.98345967
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97643183
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.95885805
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.90111029
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86514576
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.77624732
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77285358
26	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.72418351
27	STAT3_23295773_ChIP-Seq_U87_Human	1.72259259
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.65896356
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65896356
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.60386032
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59347099
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.56978930
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56602025
34	TCF4_23295773_ChIP-Seq_U87_Human	1.55419551
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53618093
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.50311136
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50238482
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.48618991
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.48346761
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.48162347
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47134307
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44171615
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44171615
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42423550
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42095353
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39449264
47	AR_25329375_ChIP-Seq_VCAP_Human	1.37429558
48	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37318435
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35749921
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35525100
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35303443
52	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.32341941
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30283629
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28015214
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26195882
56	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25043719
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23489137
58	E2F7_22180533_ChIP-Seq_HELA_Human	1.22987621
59	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.21920915
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20998756
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18641672
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18579004
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18211404
64	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.18165262
65	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17890623
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17572482
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16229098
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.15279513
69	GATA1_22025678_ChIP-Seq_K562_Human	1.14780775
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13968073
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.13926751
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13159816
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11765713
74	TP53_22573176_ChIP-Seq_HFKS_Human	1.11531066
75	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10809883
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09957169
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07548957
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.07154460
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05776668
80	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.04566193
81	RXR_22108803_ChIP-Seq_LS180_Human	1.04306056
82	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.04115444
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03858930
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03151491
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02258067
86	TBL1_22424771_ChIP-Seq_293T_Human	1.01369543
87	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.01361819
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00752031
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.00391581
90	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00321728
91	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00321728
92	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99415247
93	TP53_16413492_ChIP-PET_HCT116_Human	0.98976236
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97255385
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97144730
96	AHR_22903824_ChIP-Seq_MCF-7_Human	0.96704186
97	MYC_18940864_ChIP-ChIP_HL60_Human	0.95522941
98	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.95354590
99	P300_18555785_Chip-Seq_ESCs_Mouse	0.94567612
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.94254846

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.36197449
2	MP0008057_abnormal_DNA_replication	2.96918123
3	MP0002102_abnormal_ear_morphology	2.88832720
4	MP0001984_abnormal_olfaction	2.81811475
5	MP0008058_abnormal_DNA_repair	2.78088975
6	MP0008877_abnormal_DNA_methylation	2.63355410
7	MP0003787_abnormal_imprinting	2.53696967
8	MP0009697_abnormal_copulation	2.45222097
9	MP0010094_abnormal_chromosome_stability	2.24407705
10	MP0003646_muscle_fatigue	2.17856611
11	MP0005253_abnormal_eye_physiology	2.15371300
12	MP0009046_muscle_twitch	2.02862560
13	MP0006072_abnormal_retinal_apoptosis	2.02196273
14	MP0002735_abnormal_chemical_nociception	1.93654636
15	MP0005187_abnormal_penis_morphology	1.83934576
16	MP0000372_irregular_coat_pigmentation	1.77179608
17	MP0005551_abnormal_eye_electrophysiolog	1.74292144
18	MP0005410_abnormal_fertilization	1.70084232
19	MP0005499_abnormal_olfactory_system	1.68219196
20	MP0005394_taste/olfaction_phenotype	1.68219196
21	MP0005075_abnormal_melanosome_morpholog	1.65942244
22	MP0003890_abnormal_embryonic-extraembry	1.61784430
23	MP0002160_abnormal_reproductive_system	1.59358459
24	MP0004484_altered_response_of	1.56663070
25	MP0008995_early_reproductive_senescence	1.52546215
26	MP0001929_abnormal_gametogenesis	1.48544942
27	MP0002837_dystrophic_cardiac_calcinosis	1.48481993
28	MP0003195_calcinosis	1.48346540
29	MP0002638_abnormal_pupillary_reflex	1.47442110
30	MP0000749_muscle_degeneration	1.46979095
31	MP0003698_abnormal_male_reproductive	1.42717047
32	MP0003221_abnormal_cardiomyocyte_apopto	1.40901159
33	MP0003693_abnormal_embryo_hatching	1.38830244
34	MP0003121_genomic_imprinting	1.34925222
35	MP0005646_abnormal_pituitary_gland	1.34212609
36	MP0002009_preneoplasia	1.33903459
37	MP0005174_abnormal_tail_pigmentation	1.31609063
38	MP0004084_abnormal_cardiac_muscle	1.30837478
39	MP0008789_abnormal_olfactory_epithelium	1.30422068
40	MP0002751_abnormal_autonomic_nervous	1.25720291
41	MP0003136_yellow_coat_color	1.25667838
42	MP0003718_maternal_effect	1.25423001
43	MP0000631_abnormal_neuroendocrine_gland	1.24954944
44	MP0006276_abnormal_autonomic_nervous	1.20838502
45	MP0000427_abnormal_hair_cycle	1.19804880
46	MP0002127_abnormal_cardiovascular_syste	1.19501491
47	MP0001529_abnormal_vocalization	1.18741817
48	MP0001968_abnormal_touch/_nociception	1.16895500
49	MP0002233_abnormal_nose_morphology	1.16780867
50	MP0004145_abnormal_muscle_electrophysio	1.16242948
51	MP0005391_vision/eye_phenotype	1.15978701
52	MP0005171_absent_coat_pigmentation	1.08033623
53	MP0002736_abnormal_nociception_after	1.07262161
54	MP0002210_abnormal_sex_determination	1.03422337
55	MP0005248_abnormal_Harderian_gland	1.02002626
56	MP0005647_abnormal_sex_gland	1.01971444
57	MP0003315_abnormal_perineum_morphology	1.01534182
58	MP0005389_reproductive_system_phenotype	0.99738770
59	MP0003283_abnormal_digestive_organ	0.99727782
60	MP0000653_abnormal_sex_gland	0.98746568
61	MP0001145_abnormal_male_reproductive	0.98107366
62	MP0001486_abnormal_startle_reflex	0.97583889
63	MP0002272_abnormal_nervous_system	0.96078254
64	MP0004215_abnormal_myocardial_fiber	0.94981471
65	MP0003937_abnormal_limbs/digits/tail_de	0.94979312
66	MP0003077_abnormal_cell_cycle	0.94436031
67	MP0004134_abnormal_chest_morphology	0.93733311
68	MP0000383_abnormal_hair_follicle	0.93306787
69	MP0002108_abnormal_muscle_morphology	0.89875856
70	MP0008872_abnormal_physiological_respon	0.89050498
71	MP0006292_abnormal_olfactory_placode	0.88951650
72	MP0003786_premature_aging	0.85485253
73	MP0002184_abnormal_innervation	0.84640760
74	MP0003950_abnormal_plasma_membrane	0.83743573
75	MP0002938_white_spotting	0.82615478
76	MP0003567_abnormal_fetal_cardiomyocyte	0.81933283
77	MP0005645_abnormal_hypothalamus_physiol	0.81725024
78	MP0004924_abnormal_behavior	0.81271684
79	MP0005386_behavior/neurological_phenoty	0.81271684
80	MP0005620_abnormal_muscle_contractility	0.80255373
81	MP0002067_abnormal_sensory_capabilities	0.79489156
82	MP0004036_abnormal_muscle_relaxation	0.78256680
83	MP0003111_abnormal_nucleus_morphology	0.78024308
84	MP0002095_abnormal_skin_pigmentation	0.77038485
85	MP0000015_abnormal_ear_pigmentation	0.76755123
86	MP0000778_abnormal_nervous_system	0.75990715
87	MP0002752_abnormal_somatic_nervous	0.75833637
88	MP0004085_abnormal_heartbeat	0.75438480
89	MP0001324_abnormal_eye_pigmentation	0.74920945
90	MP0000371_diluted_coat_color	0.74835639
91	MP0004133_heterotaxia	0.74274270
92	MP0010678_abnormal_skin_adnexa	0.73765045
93	MP0000516_abnormal_urinary_system	0.73743366
94	MP0005367_renal/urinary_system_phenotyp	0.73743366
95	MP0002269_muscular_atrophy	0.73701240
96	MP0004043_abnormal_pH_regulation	0.72009825
97	MP0009745_abnormal_behavioral_response	0.71944454
98	MP0001485_abnormal_pinna_reflex	0.70588743
99	MP0000647_abnormal_sebaceous_gland	0.70459131
100	MP0009115_abnormal_fat_cell	0.70158109

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.82847116
2	Chronic hepatic failure (HP:0100626)	3.59954364
3	Hyperventilation (HP:0002883)	3.57536806
4	Pancreatic fibrosis (HP:0100732)	3.55383275
5	True hermaphroditism (HP:0010459)	3.49218713
6	Volvulus (HP:0002580)	3.00699054
7	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.96378702
8	Molar tooth sign on MRI (HP:0002419)	2.82766294
9	Abnormality of midbrain morphology (HP:0002418)	2.82766294
10	Chromsome breakage (HP:0040012)	2.80345105
11	Abnormality of the renal cortex (HP:0011035)	2.76114269
12	Intestinal atresia (HP:0011100)	2.75896453
13	Gaze-evoked nystagmus (HP:0000640)	2.70137650
14	Abnormality of chromosome stability (HP:0003220)	2.68056386
15	Nephronophthisis (HP:0000090)	2.65840031
16	Abnormal biliary tract physiology (HP:0012439)	2.65510608
17	Bile duct proliferation (HP:0001408)	2.65510608
18	Renal cortical cysts (HP:0000803)	2.63934063
19	Type II lissencephaly (HP:0007260)	2.59815476
20	Tubulointerstitial nephritis (HP:0001970)	2.57686106
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.57627934
22	Cerebellar dysplasia (HP:0007033)	2.56426271
23	Abnormality of the ileum (HP:0001549)	2.53914518
24	Hypothermia (HP:0002045)	2.53156499
25	Medial flaring of the eyebrow (HP:0010747)	2.51456392
26	Cystic liver disease (HP:0006706)	2.50075095
27	Inability to walk (HP:0002540)	2.42617652
28	Abnormality of the renal medulla (HP:0100957)	2.41776691
29	Thyroiditis (HP:0100646)	2.34269040
30	Protruding tongue (HP:0010808)	2.33350964
31	Long clavicles (HP:0000890)	2.32995217
32	Abnormality of the labia minora (HP:0012880)	2.30354782
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.29966223
34	Meckel diverticulum (HP:0002245)	2.29897817
35	Febrile seizures (HP:0002373)	2.23911048
36	Absent speech (HP:0001344)	2.23017257
37	Sloping forehead (HP:0000340)	2.22584170
38	Duplicated collecting system (HP:0000081)	2.19147073
39	Congenital primary aphakia (HP:0007707)	2.18130556
40	Calf muscle hypertrophy (HP:0008981)	2.17811636
41	Birth length less than 3rd percentile (HP:0003561)	2.16720311
42	Progressive cerebellar ataxia (HP:0002073)	2.15874398
43	Genital tract atresia (HP:0001827)	2.13153719
44	Small hand (HP:0200055)	2.12923063
45	Abnormality of the renal collecting system (HP:0004742)	2.12913222
46	Clubbing of toes (HP:0100760)	2.12428614
47	Gait imbalance (HP:0002141)	2.10211331
48	Abnormality of the pons (HP:0007361)	2.09827839
49	Progressive inability to walk (HP:0002505)	2.09361518
50	Neoplasm of the adrenal cortex (HP:0100641)	2.09293943
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.09004744
52	Nephrogenic diabetes insipidus (HP:0009806)	2.07187924
53	Hepatoblastoma (HP:0002884)	2.05209970
54	Poor coordination (HP:0002370)	2.04828197
55	Widely spaced teeth (HP:0000687)	2.02166648
56	Postaxial foot polydactyly (HP:0001830)	2.00029616
57	Broad-based gait (HP:0002136)	1.98724553
58	Vaginal atresia (HP:0000148)	1.97506226
59	Male pseudohermaphroditism (HP:0000037)	1.96448502
60	Cupped ear (HP:0000378)	1.96440648
61	Abnormality of the preputium (HP:0100587)	1.95079690
62	Anencephaly (HP:0002323)	1.93007785
63	Fair hair (HP:0002286)	1.92811982
64	Ectopic kidney (HP:0000086)	1.92333439
65	Lissencephaly (HP:0001339)	1.91053640
66	Atonic seizures (HP:0010819)	1.88389844
67	Oligodactyly (hands) (HP:0001180)	1.87646774
68	Astigmatism (HP:0000483)	1.86099263
69	Drooling (HP:0002307)	1.85159663
70	Muscle hypertrophy of the lower extremities (HP:0008968)	1.83585702
71	Attenuation of retinal blood vessels (HP:0007843)	1.82642653
72	Hypoplasia of the pons (HP:0012110)	1.81888584
73	Pancreatic islet-cell hyperplasia (HP:0004510)	1.80780204
74	Gastrointestinal atresia (HP:0002589)	1.80388347
75	Decreased lacrimation (HP:0000633)	1.80226948
76	Papillary thyroid carcinoma (HP:0002895)	1.80172403
77	Abnormality of the columella (HP:0009929)	1.79788784
78	Congenital stationary night blindness (HP:0007642)	1.79656094
79	Sensory axonal neuropathy (HP:0003390)	1.79250859
80	Dyskinesia (HP:0100660)	1.78631286
81	Hypoplastic labia majora (HP:0000059)	1.78175561
82	Congenital hepatic fibrosis (HP:0002612)	1.77866941
83	Postaxial hand polydactyly (HP:0001162)	1.77835149
84	Large for gestational age (HP:0001520)	1.76833095
85	Stomach cancer (HP:0012126)	1.74795958
86	Truncal obesity (HP:0001956)	1.73217632
87	Occipital encephalocele (HP:0002085)	1.72930230
88	Preaxial hand polydactyly (HP:0001177)	1.72604275
89	Abnormality of DNA repair (HP:0003254)	1.71056932
90	Furrowed tongue (HP:0000221)	1.69326560
91	Neoplasm of the oral cavity (HP:0100649)	1.64683010
92	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.64307492
93	Tented upper lip vermilion (HP:0010804)	1.64018263
94	Retinal dysplasia (HP:0007973)	1.63296113
95	Rimmed vacuoles (HP:0003805)	1.63081047
96	Excessive salivation (HP:0003781)	1.62934029
97	Abnormality of the astrocytes (HP:0100707)	1.62124186
98	Astrocytoma (HP:0009592)	1.62124186
99	Abnormality of the labia majora (HP:0012881)	1.61981444
100	Abnormality of the duodenum (HP:0002246)	1.61911714

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.74332554
2	PINK1	3.57124636
3	TRIM28	3.30970169
4	MAP4K2	3.02682215
5	MAP2K7	2.75801567
6	MAP3K4	2.65742416
7	BMPR1B	2.60288718
8	OBSCN	2.43082660
9	MARK3	2.41295606
10	ZAK	2.14765470
11	TNIK	2.12810251
12	WNK3	2.01066178
13	ACVR1B	1.93542762
14	EIF2AK3	1.83905294
15	STK38L	1.77140839
16	CSNK1A1L	1.74836763
17	CSNK1G1	1.73486156
18	LATS1	1.65682302
19	CASK	1.54457029
20	CSNK1G3	1.47982260
21	AKT3	1.44985907
22	MAPK13	1.41407479
23	NUAK1	1.39380376
24	FGFR2	1.37624946
25	INSRR	1.28733155
26	NEK2	1.26833387
27	CSNK1G2	1.25492603
28	ERBB3	1.25087704
29	GRK1	1.24374415
30	SRPK1	1.20453305
31	BCR	1.20379827
32	ADRBK2	1.20372441
33	STK39	1.19870615
34	MKNK2	1.18655104
35	CCNB1	1.14562427
36	NLK	1.14366905
37	TLK1	1.13751353
38	BRD4	1.12815673
39	PAK3	1.09718691
40	SGK2	1.09094199
41	BRSK2	1.05847015
42	PLK4	1.03882157
43	CDK3	1.00213433
44	TGFBR1	0.89717384
45	CDC7	0.88755136
46	ATM	0.81229981
47	CAMK1G	0.78233139
48	DYRK3	0.76547366
49	SGK223	0.75921617
50	SGK494	0.75921617
51	WNK4	0.75044800
52	ATR	0.74190840
53	MKNK1	0.73561970
54	PLK2	0.73358289
55	RPS6KB1	0.70523921
56	EPHA4	0.69701606
57	VRK1	0.64632097
58	PLK1	0.62994736
59	NEK1	0.61672455
60	RPS6KA5	0.61519686
61	MAP2K4	0.60164045
62	OXSR1	0.59599831
63	PTK2B	0.57422879
64	STK3	0.54679224
65	FER	0.53217091
66	CSNK1D	0.52736622
67	WEE1	0.49241394
68	PNCK	0.48789029
69	PLK3	0.48285081
70	RPS6KA4	0.47653003
71	TEC	0.46917449
72	PRKAA1	0.44640131
73	WNK1	0.43850892
74	PRKCQ	0.43741603
75	PRKCE	0.43176388
76	CSNK1A1	0.42671863
77	CAMK1D	0.42255543
78	TRPM7	0.40740214
79	SGK3	0.39976907
80	KSR1	0.39564797
81	PIK3CG	0.38624000
82	CAMK4	0.37266706
83	CHEK1	0.37115757
84	MARK1	0.36421936
85	PRKACB	0.36124423
86	MELK	0.35062730
87	MST4	0.34205435
88	PKN1	0.33907044
89	EGFR	0.33407891
90	TXK	0.32169722
91	AURKB	0.31246865
92	DAPK2	0.30190921
93	NTRK2	0.29603393
94	CAMKK2	0.29177893
95	PIK3CA	0.28741344
96	ADRBK1	0.28534966
97	PHKG1	0.27715954
98	PHKG2	0.27715954
99	PIM1	0.27674540
100	PRKG1	0.26987070

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	3.37222371
2	Non-homologous end-joining_Homo sapiens_hsa03450	2.82332591
3	Homologous recombination_Homo sapiens_hsa03440	2.81891029
4	Olfactory transduction_Homo sapiens_hsa04740	2.73088503
5	Phototransduction_Homo sapiens_hsa04744	2.71377832
6	Butanoate metabolism_Homo sapiens_hsa00650	2.47306119
7	Basal transcription factors_Homo sapiens_hsa03022	2.45716991
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.26684442
9	Propanoate metabolism_Homo sapiens_hsa00640	2.15016747
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.02769674
11	RNA degradation_Homo sapiens_hsa03018	1.99055388
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.85026593
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.76526304
14	Circadian rhythm_Homo sapiens_hsa04710	1.64453281
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.63745977
16	Taste transduction_Homo sapiens_hsa04742	1.55755208
17	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.51019047
18	Regulation of autophagy_Homo sapiens_hsa04140	1.43355633
19	Oocyte meiosis_Homo sapiens_hsa04114	1.39793067
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.39666619
21	Protein export_Homo sapiens_hsa03060	1.38190197
22	Nicotine addiction_Homo sapiens_hsa05033	1.36029928
23	Mismatch repair_Homo sapiens_hsa03430	1.33749258
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.32148716
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32080649
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.31262643
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.30678047
28	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.28829363
29	Histidine metabolism_Homo sapiens_hsa00340	1.24797589
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.22539865
31	RNA transport_Homo sapiens_hsa03013	1.22169077
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.21627006
33	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.16048020
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11952971
35	Lysine degradation_Homo sapiens_hsa00310	1.08933508
36	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.07619987
37	Caffeine metabolism_Homo sapiens_hsa00232	1.06671976
38	Alcoholism_Homo sapiens_hsa05034	1.05782214
39	mRNA surveillance pathway_Homo sapiens_hsa03015	1.04225402
40	ABC transporters_Homo sapiens_hsa02010	1.02324858
41	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.99563306
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.99268561
43	Peroxisome_Homo sapiens_hsa04146	0.95581573
44	Circadian entrainment_Homo sapiens_hsa04713	0.94690160
45	Salivary secretion_Homo sapiens_hsa04970	0.94385489
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.93983608
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92730104
48	Linoleic acid metabolism_Homo sapiens_hsa00591	0.88546874
49	DNA replication_Homo sapiens_hsa03030	0.87036688
50	Calcium signaling pathway_Homo sapiens_hsa04020	0.86359372
51	Purine metabolism_Homo sapiens_hsa00230	0.84932538
52	FoxO signaling pathway_Homo sapiens_hsa04068	0.81270509
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81156237
54	Cell cycle_Homo sapiens_hsa04110	0.79261175
55	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.76682170
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.73366445
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72717152
58	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.71832504
59	GABAergic synapse_Homo sapiens_hsa04727	0.71645717
60	Renin secretion_Homo sapiens_hsa04924	0.70503901
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.70190426
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.69369458
63	Dopaminergic synapse_Homo sapiens_hsa04728	0.68713810
64	Morphine addiction_Homo sapiens_hsa05032	0.67225099
65	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.67146728
66	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.66554748
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65819017
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62573429
69	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.62214315
70	p53 signaling pathway_Homo sapiens_hsa04115	0.60547303
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58883196
72	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.57971451
73	Spliceosome_Homo sapiens_hsa03040	0.57191064
74	Glucagon signaling pathway_Homo sapiens_hsa04922	0.56692826
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55155438
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55090500
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54538138
78	Insulin secretion_Homo sapiens_hsa04911	0.54112402
79	Amphetamine addiction_Homo sapiens_hsa05031	0.53390959
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.50791617
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.49073980
82	Primary immunodeficiency_Homo sapiens_hsa05340	0.48440346
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47935357
84	One carbon pool by folate_Homo sapiens_hsa00670	0.47469700
85	Retinol metabolism_Homo sapiens_hsa00830	0.47016935
86	Renin-angiotensin system_Homo sapiens_hsa04614	0.46273568
87	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.45992132
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.44526154
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44123975
90	Long-term depression_Homo sapiens_hsa04730	0.44108843
91	RNA polymerase_Homo sapiens_hsa03020	0.43749239
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.43660787
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42969969
94	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.42907005
95	Melanoma_Homo sapiens_hsa05218	0.41785002
96	Asthma_Homo sapiens_hsa05310	0.41043459
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40554785
98	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.39938150
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.38767551
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38472659

PARGP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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