PARK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.93645527
2telomere maintenance via semi-conservative replication (GO:0032201)4.65708067
3proteasome assembly (GO:0043248)4.58445635
4rRNA modification (GO:0000154)4.42355196
5telomere maintenance via recombination (GO:0000722)4.35749939
6regulation of nuclear cell cycle DNA replication (GO:0033262)4.32812742
7DNA replication initiation (GO:0006270)4.22852735
8DNA deamination (GO:0045006)4.21228282
9fucose catabolic process (GO:0019317)4.15012762
10L-fucose metabolic process (GO:0042354)4.15012762
11L-fucose catabolic process (GO:0042355)4.15012762
12transcription elongation from RNA polymerase III promoter (GO:0006385)4.10587453
13termination of RNA polymerase III transcription (GO:0006386)4.10587453
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.03237797
15kinetochore assembly (GO:0051382)4.01239910
16ribosome biogenesis (GO:0042254)3.99455445
17purine nucleobase biosynthetic process (GO:0009113)3.98180480
18maturation of 5.8S rRNA (GO:0000460)3.87759150
19neuronal action potential propagation (GO:0019227)3.83333961
207-methylguanosine mRNA capping (GO:0006370)3.82473045
21mitotic recombination (GO:0006312)3.82247960
22transcription from RNA polymerase I promoter (GO:0006360)3.79898226
23ribosome assembly (GO:0042255)3.78873484
247-methylguanosine RNA capping (GO:0009452)3.78225343
25RNA capping (GO:0036260)3.78225343
26DNA replication checkpoint (GO:0000076)3.73705162
27telomere maintenance via telomere lengthening (GO:0010833)3.69012460
28termination of RNA polymerase I transcription (GO:0006363)3.66358609
29kinetochore organization (GO:0051383)3.64944756
30rRNA methylation (GO:0031167)3.64574149
31DNA strand elongation involved in DNA replication (GO:0006271)3.62901399
32nucleobase biosynthetic process (GO:0046112)3.60737057
33CENP-A containing nucleosome assembly (GO:0034080)3.56531044
34DNA strand elongation (GO:0022616)3.56001063
35platelet dense granule organization (GO:0060155)3.53067128
36transcription elongation from RNA polymerase I promoter (GO:0006362)3.52865405
37cellular ketone body metabolic process (GO:0046950)3.49574317
38regulation of double-strand break repair via homologous recombination (GO:0010569)3.49034821
39replication fork processing (GO:0031297)3.48768699
40DNA-dependent DNA replication (GO:0006261)3.48359212
41meiotic chromosome segregation (GO:0045132)3.45276174
42chromatin remodeling at centromere (GO:0031055)3.44169590
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43004080
44maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.42785631
45gamma-aminobutyric acid transport (GO:0015812)3.41301894
46transcription-coupled nucleotide-excision repair (GO:0006283)3.41182093
47pseudouridine synthesis (GO:0001522)3.38343036
48negative regulation of cytosolic calcium ion concentration (GO:0051481)3.38262936
49DNA double-strand break processing (GO:0000729)3.36619000
50transcription initiation from RNA polymerase I promoter (GO:0006361)3.34124673
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33820756
52regulation of mitochondrial translation (GO:0070129)3.28708914
53regulation of action potential (GO:0098900)3.25836571
54tRNA methylation (GO:0030488)3.24542931
55negative regulation of DNA-dependent DNA replication (GO:2000104)3.23218576
56DNA synthesis involved in DNA repair (GO:0000731)3.21930901
57mitotic metaphase plate congression (GO:0007080)3.20945029
58response to pheromone (GO:0019236)3.17991076
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15885365
60regulation of mitotic spindle checkpoint (GO:1903504)3.15885365
61membrane depolarization during action potential (GO:0086010)3.14759060
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14567388
63piRNA metabolic process (GO:0034587)3.14499101
64ketone body metabolic process (GO:1902224)3.12555749
65regulation of skeletal muscle contraction (GO:0014819)3.11162140
66synaptic transmission, cholinergic (GO:0007271)3.10666231
67centriole assembly (GO:0098534)3.08012385
68DNA catabolic process, exonucleolytic (GO:0000738)3.07774628
69axoneme assembly (GO:0035082)3.07136388
70neuronal action potential (GO:0019228)3.06353389
71water-soluble vitamin biosynthetic process (GO:0042364)3.06074974
72viral mRNA export from host cell nucleus (GO:0046784)3.05929515
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05764953
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05646982
75DNA integration (GO:0015074)3.05393054
76detection of light stimulus involved in sensory perception (GO:0050962)3.04926614
77detection of light stimulus involved in visual perception (GO:0050908)3.04926614
78glycerophospholipid catabolic process (GO:0046475)3.03648803
79deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.01639546
80telomere maintenance (GO:0000723)3.00429641
81protein polyglutamylation (GO:0018095)3.00427337
82ribonucleoprotein complex biogenesis (GO:0022613)3.00382241
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00359559
84telomere organization (GO:0032200)2.99166065
85regulation of centriole replication (GO:0046599)2.98425963
86epithelial cilium movement (GO:0003351)2.97895025
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95906650
88reciprocal DNA recombination (GO:0035825)2.93597156
89reciprocal meiotic recombination (GO:0007131)2.93597156
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91856397
91C4-dicarboxylate transport (GO:0015740)2.90822434
92deoxyribonucleotide biosynthetic process (GO:0009263)2.90253253
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.89496764
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.89496764
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.89496764
96guanosine-containing compound biosynthetic process (GO:1901070)2.88830444
97transcription elongation from RNA polymerase II promoter (GO:0006368)2.88393413
98protein complex biogenesis (GO:0070271)2.88044944
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86620198
100muscle filament sliding (GO:0030049)2.85113561
101actin-myosin filament sliding (GO:0033275)2.85113561
102proline transport (GO:0015824)2.84314148
103neuromuscular synaptic transmission (GO:0007274)2.84065680
104DNA replication-independent nucleosome assembly (GO:0006336)2.83795393
105DNA replication-independent nucleosome organization (GO:0034724)2.83795393
106regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.83384203
107postsynaptic membrane organization (GO:0001941)2.83137201
108replicative senescence (GO:0090399)2.82724008
109histone exchange (GO:0043486)2.82614387
110ubiquinone biosynthetic process (GO:0006744)2.81434825
111nephron tubule morphogenesis (GO:0072078)2.81287868
112nephron epithelium morphogenesis (GO:0072088)2.81287868
113metaphase plate congression (GO:0051310)2.81274359
114cell cycle G1/S phase transition (GO:0044843)2.80778656
115G1/S transition of mitotic cell cycle (GO:0000082)2.80778656
116establishment of chromosome localization (GO:0051303)2.80344063
117IMP biosynthetic process (GO:0006188)2.79588215
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78616245
119cytochrome complex assembly (GO:0017004)2.78331759
120regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78198550
121sarcoplasmic reticulum calcium ion transport (GO:0070296)2.77973525
122negative regulation of mitotic sister chromatid separation (GO:2000816)2.77107819
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77107819
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77107819
125negative regulation of sister chromatid segregation (GO:0033046)2.77107819
126DNA-templated transcription, elongation (GO:0006354)2.76450534
127negative regulation of telomere maintenance (GO:0032205)2.76016106
128signal transduction involved in cell cycle checkpoint (GO:0072395)2.75767875
129intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75133339
130signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75133339
131DNA biosynthetic process (GO:0071897)2.75097145
132regulation of neurotransmitter uptake (GO:0051580)2.74798757
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74752554
134auditory receptor cell stereocilium organization (GO:0060088)2.74520128
135ribosomal large subunit biogenesis (GO:0042273)2.74303378
136pyrimidine nucleobase catabolic process (GO:0006208)2.74076799
137signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74056991
138signal transduction involved in DNA damage checkpoint (GO:0072422)2.74056991
139regulation of membrane repolarization (GO:0060306)2.73299370
140spindle checkpoint (GO:0031577)2.73045866
141negative regulation of chromosome segregation (GO:0051985)2.72882924
142rRNA processing (GO:0006364)2.72604090
143kynurenine metabolic process (GO:0070189)2.71873796
144spliceosomal snRNP assembly (GO:0000387)2.71692310
145regulation of relaxation of muscle (GO:1901077)2.70966938
146DNA replication (GO:0006260)2.69989120
147alanine transport (GO:0032328)2.69984657
148mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.69117274
149primary amino compound metabolic process (GO:1901160)2.69061223
150superoxide anion generation (GO:0042554)2.69058765
151action potential (GO:0001508)2.66535075
152ubiquinone metabolic process (GO:0006743)2.63897328
153somite development (GO:0061053)2.63401966
154regulation of cell communication by electrical coupling (GO:0010649)2.62426393
155transmission of nerve impulse (GO:0019226)2.60042690
156mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60029039
157mitochondrial respiratory chain complex I assembly (GO:0032981)2.60029039
158NADH dehydrogenase complex assembly (GO:0010257)2.60029039
159G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59927756
160aspartate family amino acid catabolic process (GO:0009068)2.58987364
161indolalkylamine catabolic process (GO:0046218)2.58855135
162tryptophan catabolic process (GO:0006569)2.58855135
163indole-containing compound catabolic process (GO:0042436)2.58855135
164serotonin metabolic process (GO:0042428)2.58119289
165DNA methylation involved in gamete generation (GO:0043046)2.57173944
166positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56555459
167protein K11-linked deubiquitination (GO:0035871)2.56139176
168cAMP catabolic process (GO:0006198)2.55826683
169mitochondrial respiratory chain complex assembly (GO:0033108)2.53969366
170cilium movement (GO:0003341)2.52667392
171nucleobase catabolic process (GO:0046113)2.51669165
172indolalkylamine metabolic process (GO:0006586)2.51377987
173positive regulation of sodium ion transmembrane transport (GO:1902307)2.50915092
174protein-cofactor linkage (GO:0018065)2.50190536
175behavioral response to ethanol (GO:0048149)2.49467786
176inner ear receptor stereocilium organization (GO:0060122)2.46194233
177renal tubule morphogenesis (GO:0061333)2.45738940
178detection of calcium ion (GO:0005513)2.44799530
179reflex (GO:0060004)2.44621403
180auditory behavior (GO:0031223)2.44070932
181protein localization to cilium (GO:0061512)2.43784003
182sulfation (GO:0051923)2.42329478
183retinal cone cell development (GO:0046549)2.42322914
184cyclic nucleotide catabolic process (GO:0009214)2.41680953
185regulation of cilium movement (GO:0003352)2.40297558
186nonmotile primary cilium assembly (GO:0035058)2.40206210
187actin-mediated cell contraction (GO:0070252)2.40065415
188positive regulation of action potential (GO:0045760)2.38328424
189negative regulation of heart rate (GO:0010459)2.37647598
190cornea development in camera-type eye (GO:0061303)2.37092110
191cilium or flagellum-dependent cell motility (GO:0001539)2.36102012
192photoreceptor cell development (GO:0042461)2.35443859
193positive regulation of potassium ion transmembrane transport (GO:1901381)2.35071367
194regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.34589064
195indole-containing compound metabolic process (GO:0042430)2.34535785
196dendritic spine morphogenesis (GO:0060997)2.34257346
197regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.32588698
198L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.30696990
199presynaptic membrane assembly (GO:0097105)2.30481713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.21510359
2EZH2_22144423_ChIP-Seq_EOC_Human4.66252241
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.46161214
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.70311691
5GBX2_23144817_ChIP-Seq_PC3_Human3.26793291
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.22222709
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.20252004
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13951807
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.12447018
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.06530185
11ZNF274_21170338_ChIP-Seq_K562_Hela3.01398677
12VDR_22108803_ChIP-Seq_LS180_Human2.94209617
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.83382015
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76391238
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.73536171
16* GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70295233
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.67901170
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50202494
19* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49268899
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47113162
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.44751593
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39057311
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38347124
24VDR_23849224_ChIP-Seq_CD4+_Human2.36847062
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33612138
26IGF1R_20145208_ChIP-Seq_DFB_Human2.31678359
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24846189
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23568610
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21172805
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20900342
31ELK1_19687146_ChIP-ChIP_HELA_Human2.18222223
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15801042
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.14272970
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08160471
35MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05754145
36TAF15_26573619_Chip-Seq_HEK293_Human2.05185208
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04871792
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00082409
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99923173
40* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98628223
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.98579906
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97155688
43FUS_26573619_Chip-Seq_HEK293_Human1.96263165
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95650015
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91633140
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90670105
47* P300_19829295_ChIP-Seq_ESCs_Human1.89513403
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85983888
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85466492
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82476166
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81907813
52FOXP3_21729870_ChIP-Seq_TREG_Human1.78132683
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.77780450
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77254252
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.72490461
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71782906
57DCP1A_22483619_ChIP-Seq_HELA_Human1.70636684
58* REST_21632747_ChIP-Seq_MESCs_Mouse1.69376336
59ER_23166858_ChIP-Seq_MCF-7_Human1.69250457
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63671534
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.62405833
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.61205718
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59926492
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59041728
65* SMAD4_21799915_ChIP-Seq_A2780_Human1.58068709
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57858163
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57481881
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.57151380
69* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57123182
70BCAT_22108803_ChIP-Seq_LS180_Human1.56908259
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55426184
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54152673
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53537709
74* EWS_26573619_Chip-Seq_HEK293_Human1.52661704
75GABP_19822575_ChIP-Seq_HepG2_Human1.51896348
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51336483
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49685939
78* STAT3_23295773_ChIP-Seq_U87_Human1.48698380
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47749460
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47130299
81* TCF4_23295773_ChIP-Seq_U87_Human1.45843799
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.44938268
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44638904
84AR_25329375_ChIP-Seq_VCAP_Human1.44586081
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44263141
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.43877617
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43586137
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42996958
89CBP_20019798_ChIP-Seq_JUKART_Human1.42400499
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42400499
91IRF1_19129219_ChIP-ChIP_H3396_Human1.41740985
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38467257
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.38160713
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37731870
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.37676151
96* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37379212
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.36929324
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36423473
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36282297
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35765026
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35425842
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.35367379
103SOX2_19829295_ChIP-Seq_ESCs_Human1.34297966
104NANOG_19829295_ChIP-Seq_ESCs_Human1.34297966
105TTF2_22483619_ChIP-Seq_HELA_Human1.34120751
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33553157
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33019859
108* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32454683
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31400820
110RNF2_27304074_Chip-Seq_NSC_Mouse1.31321289
111JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29330698
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28763561
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28593009
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28593009
115KAP1_22055183_ChIP-Seq_ESCs_Mouse1.28167858
116* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27024100
117* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26440109
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25689954
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.25552200
120TP53_22573176_ChIP-Seq_HFKS_Human1.25078405
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24040067
122EZH2_27294783_Chip-Seq_ESCs_Mouse1.23779170
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.22604868
124FOXM1_23109430_ChIP-Seq_U2OS_Human1.21805494
125XRN2_22483619_ChIP-Seq_HELA_Human1.20891750
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20634542
127PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19598173
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.15802413
129EED_16625203_ChIP-ChIP_MESCs_Mouse1.15202587
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.15100662
131* TCF4_22108803_ChIP-Seq_LS180_Human1.14676304
132AR_21572438_ChIP-Seq_LNCaP_Human1.13874748
133DROSHA_22980978_ChIP-Seq_HELA_Human1.13555253
134ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13405014
135RUNX2_22187159_ChIP-Seq_PCA_Human1.13394063
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11504067
137* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09915216
138JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09400379
139PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08764935
140NCOR_22424771_ChIP-Seq_293T_Human1.08413111
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07836551
142* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06471981
143SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06016110
144ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05114016
145CRX_20693478_ChIP-Seq_RETINA_Mouse1.05047406
146NANOG_18555785_Chip-Seq_ESCs_Mouse1.04656717
147PRDM14_20953172_ChIP-Seq_ESCs_Human1.04407926
148SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03798784
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02414596
150P53_22387025_ChIP-Seq_ESCs_Mouse1.01881772
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01673179
152IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01241596
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01000866
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00742846
155STAT3_18555785_Chip-Seq_ESCs_Mouse1.00307038
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99798611
157FOXA1_25329375_ChIP-Seq_VCAP_Human0.99798611
158KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99719169
159KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99719169
160KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99719169
161SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98874947
162* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98176895
163MYC_18940864_ChIP-ChIP_HL60_Human0.96166223
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.96044424
165AR_21909140_ChIP-Seq_LNCAP_Human0.94243911
166SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94132179
167NMYC_18555785_Chip-Seq_ESCs_Mouse0.92810784
168ELK1_22589737_ChIP-Seq_MCF10A_Human0.89186427
169SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88443233
170* IRF8_21731497_ChIP-ChIP_J774_Mouse0.87700077
171RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87602149
172E2F1_18555785_Chip-Seq_ESCs_Mouse0.87342186
173NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87312772
174RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86101620
175ZFX_18555785_Chip-Seq_ESCs_Mouse0.82910019
176SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82379880
177BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82024211
178KLF4_18555785_Chip-Seq_ESCs_Mouse0.81496795
179OCT4_18555785_Chip-Seq_ESCs_Mouse0.81349938
180DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80770000
181SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80386712
182NANOG_16153702_ChIP-ChIP_HESCs_Human0.80070562
183P300_18555785_Chip-Seq_ESCs_Mouse0.79889888
184SMAD1_18555785_Chip-Seq_ESCs_Mouse0.79657585
185EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.79009944
186SOX17_20123909_ChIP-Seq_XEN_Mouse0.78675342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.11221166
2MP0008058_abnormal_DNA_repair3.91705250
3MP0006292_abnormal_olfactory_placode3.84750214
4MP0008057_abnormal_DNA_replication3.26958230
5MP0010094_abnormal_chromosome_stability3.21078045
6MP0002837_dystrophic_cardiac_calcinosis3.10054241
7MP0004145_abnormal_muscle_electrophysio3.08604890
8MP0003111_abnormal_nucleus_morphology3.02033790
9MP0003136_yellow_coat_color2.95639773
10MP0001188_hyperpigmentation2.94634938
11MP0003786_premature_aging2.83043578
12MP0008007_abnormal_cellular_replicative2.61102875
13MP0003718_maternal_effect2.49599256
14MP0003880_abnormal_central_pattern2.45631394
15MP0005171_absent_coat_pigmentation2.41173789
16MP0003077_abnormal_cell_cycle2.40081592
17MP0003941_abnormal_skin_development2.38569761
18MP0000015_abnormal_ear_pigmentation2.37587147
19MP0008877_abnormal_DNA_methylation2.37549095
20MP0003195_calcinosis2.34136508
21MP0001968_abnormal_touch/_nociception2.15374865
22MP0008932_abnormal_embryonic_tissue2.13924574
23MP0004957_abnormal_blastocyst_morpholog2.12259219
24MP0005551_abnormal_eye_electrophysiolog2.11021125
25MP0002132_abnormal_respiratory_system2.09287815
26MP0009697_abnormal_copulation2.08474282
27MP0004885_abnormal_endolymph2.07685683
28MP0006072_abnormal_retinal_apoptosis2.07018513
29* MP0002272_abnormal_nervous_system2.06429138
30* MP0009745_abnormal_behavioral_response2.06348805
31MP0009046_muscle_twitch2.06063358
32MP0001984_abnormal_olfaction1.93998772
33MP0004215_abnormal_myocardial_fiber1.90307402
34MP0002277_abnormal_respiratory_mucosa1.87079026
35MP0005075_abnormal_melanosome_morpholog1.83902697
36MP0002160_abnormal_reproductive_system1.82274137
37MP0005423_abnormal_somatic_nervous1.78759184
38MP0002638_abnormal_pupillary_reflex1.77459722
39MP0002736_abnormal_nociception_after1.75569385
40MP0004142_abnormal_muscle_tone1.72224255
41MP0000372_irregular_coat_pigmentation1.66547852
42MP0006276_abnormal_autonomic_nervous1.65494750
43MP0000566_synostosis1.65173448
44MP0001501_abnormal_sleep_pattern1.65161626
45MP0002064_seizures1.61947786
46* MP0001486_abnormal_startle_reflex1.61323260
47MP0001485_abnormal_pinna_reflex1.60462643
48MP0002876_abnormal_thyroid_physiology1.60243865
49MP0004270_analgesia1.60234970
50MP0005253_abnormal_eye_physiology1.59244151
51MP0003011_delayed_dark_adaptation1.58192897
52MP0001986_abnormal_taste_sensitivity1.56830349
53MP0005389_reproductive_system_phenotype1.56618842
54MP0005367_renal/urinary_system_phenotyp1.56500099
55MP0000516_abnormal_urinary_system1.56500099
56MP0004130_abnormal_muscle_cell1.56011234
57MP0004043_abnormal_pH_regulation1.53710012
58MP0005646_abnormal_pituitary_gland1.53569391
59* MP0003635_abnormal_synaptic_transmissio1.53303421
60MP0005409_darkened_coat_color1.51030445
61MP0002396_abnormal_hematopoietic_system1.50265862
62MP0002095_abnormal_skin_pigmentation1.49906217
63MP0002210_abnormal_sex_determination1.48313355
64* MP0002572_abnormal_emotion/affect_behav1.47249884
65MP0008872_abnormal_physiological_respon1.47035188
66MP0003137_abnormal_impulse_conducting1.41685143
67MP0003283_abnormal_digestive_organ1.38534067
68MP0002734_abnormal_mechanical_nocicepti1.37452944
69MP0000749_muscle_degeneration1.36272168
70MP0004084_abnormal_cardiac_muscle1.34372353
71MP0002735_abnormal_chemical_nociception1.33787205
72MP0004782_abnormal_surfactant_physiolog1.33414133
73* MP0002063_abnormal_learning/memory/cond1.31696280
74MP0001119_abnormal_female_reproductive1.31539274
75MP0004036_abnormal_muscle_relaxation1.30342513
76MP0003123_paternal_imprinting1.29869570
77MP0001186_pigmentation_phenotype1.28165691
78MP0000631_abnormal_neuroendocrine_gland1.27462731
79MP0001919_abnormal_reproductive_system1.25970662
80MP0002067_abnormal_sensory_capabilities1.24963640
81MP0002557_abnormal_social/conspecific_i1.23953988
82MP0003879_abnormal_hair_cell1.23829044
83MP0002653_abnormal_ependyma_morphology1.23395454
84MP0008995_early_reproductive_senescence1.21003508
85MP0003122_maternal_imprinting1.20936988
86MP0001970_abnormal_pain_threshold1.20228570
87MP0008775_abnormal_heart_ventricle1.19544590
88MP0003315_abnormal_perineum_morphology1.17970660
89MP0008875_abnormal_xenobiotic_pharmacok1.17905503
90MP0002938_white_spotting1.17753551
91* MP0003186_abnormal_redox_activity1.16202545
92MP0000678_abnormal_parathyroid_gland1.16088697
93MP0004924_abnormal_behavior1.16082813
94MP0005386_behavior/neurological_phenoty1.16082813
95MP0002733_abnormal_thermal_nociception1.15238512
96MP0005620_abnormal_muscle_contractility1.14423096
97MP0001835_abnormal_antigen_presentation1.14111333
98MP0005377_hearing/vestibular/ear_phenot1.11985039
99MP0003878_abnormal_ear_physiology1.11985039
100MP0005174_abnormal_tail_pigmentation1.11262400
101MP0000013_abnormal_adipose_tissue1.10611945
102MP0002106_abnormal_muscle_physiology1.10126544
103MP0001529_abnormal_vocalization1.10081101
104MP0004484_altered_response_of1.09896398
105MP0002148_abnormal_hypersensitivity_rea1.09396860
106MP0002102_abnormal_ear_morphology1.07224482
107MP0004085_abnormal_heartbeat1.06601370
108MP0001145_abnormal_male_reproductive1.06470078
109MP0004742_abnormal_vestibular_system1.06152488
110MP0002928_abnormal_bile_duct1.06130393
111MP0004859_abnormal_synaptic_plasticity1.05525977
112MP0001929_abnormal_gametogenesis1.04902384
113MP0005379_endocrine/exocrine_gland_phen1.04618774
114MP0009780_abnormal_chondrocyte_physiolo1.02613696
115MP0001764_abnormal_homeostasis1.02220565
116MP0002184_abnormal_innervation1.01393430
117MP0001440_abnormal_grooming_behavior1.01299695
118MP0009333_abnormal_splenocyte_physiolog1.00741179
119MP0002909_abnormal_adrenal_gland0.99959425
120MP0000653_abnormal_sex_gland0.99886265
121* MP0006036_abnormal_mitochondrial_physio0.99546285
122MP0004147_increased_porphyrin_level0.99131234
123MP0003121_genomic_imprinting0.98724277
124MP0001542_abnormal_bone_strength0.96932139
125MP0000778_abnormal_nervous_system0.96782555
126MP0002075_abnormal_coat/hair_pigmentati0.96547865
127MP0008260_abnormal_autophagy0.96205065
128MP0000751_myopathy0.95511951
129MP0001963_abnormal_hearing_physiology0.93722264
130MP0000490_abnormal_crypts_of0.93520557
131MP0005369_muscle_phenotype0.93385578
132MP0002751_abnormal_autonomic_nervous0.92891647
133MP0002234_abnormal_pharynx_morphology0.92757027
134MP0001502_abnormal_circadian_rhythm0.91192158
135MP0001293_anophthalmia0.90390549
136MP0000049_abnormal_middle_ear0.89746921
137MP0000681_abnormal_thyroid_gland0.89472331
138MP0005332_abnormal_amino_acid0.89311375
139MP0002752_abnormal_somatic_nervous0.87770941
140MP0008789_abnormal_olfactory_epithelium0.87657041
141MP0000313_abnormal_cell_death0.86441115
142MP0003890_abnormal_embryonic-extraembry0.85368863
143MP0001545_abnormal_hematopoietic_system0.84964748
144MP0005397_hematopoietic_system_phenotyp0.84964748
145MP0005167_abnormal_blood-brain_barrier0.84357570
146MP0005084_abnormal_gallbladder_morpholo0.84053613
147MP0000427_abnormal_hair_cycle0.83275293
148MP0000569_abnormal_digit_pigmentation0.82651752
149* MP0002229_neurodegeneration0.82639928
150MP0000230_abnormal_systemic_arterial0.81911266
151MP0005195_abnormal_posterior_eye0.81418461
152MP0002163_abnormal_gland_morphology0.81102441
153MP0003646_muscle_fatigue0.80588760
154MP0004133_heterotaxia0.80409510
155MP0003698_abnormal_male_reproductive0.78412905
156MP0005395_other_phenotype0.75390608
157MP0005394_taste/olfaction_phenotype0.75130660
158MP0005499_abnormal_olfactory_system0.75130660
159MP0005671_abnormal_response_to0.74587078
160MP0005670_abnormal_white_adipose0.74559816
161MP0003938_abnormal_ear_development0.72598012
162MP0001177_atelectasis0.70947372
163MP0000371_diluted_coat_color0.70681432
164MP0005645_abnormal_hypothalamus_physiol0.70627200
165MP0000350_abnormal_cell_proliferation0.70337418
166MP0004381_abnormal_hair_follicle0.69945628
167MP0002177_abnormal_outer_ear0.69469801
168MP0003787_abnormal_imprinting0.68728211
169MP0003936_abnormal_reproductive_system0.66746017
170MP0009785_altered_susceptibility_to0.64149982
171MP0010386_abnormal_urinary_bladder0.63105287
172MP0001672_abnormal_embryogenesis/_devel0.63035967
173MP0005380_embryogenesis_phenotype0.63035967
174MP0005408_hypopigmentation0.62520938
175MP0000026_abnormal_inner_ear0.61275093
176MP0004808_abnormal_hematopoietic_stem0.59023965
177MP0002419_abnormal_innate_immunity0.58387799
178MP0005410_abnormal_fertilization0.58181711
179MP0005257_abnormal_intraocular_pressure0.57160853

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.22245325
2Chromsome breakage (HP:0040012)4.88058917
3Birth length less than 3rd percentile (HP:0003561)4.25482218
4Molar tooth sign on MRI (HP:0002419)3.45443899
5Abnormality of midbrain morphology (HP:0002418)3.45443899
6Type I transferrin isoform profile (HP:0003642)3.31283015
7Meckel diverticulum (HP:0002245)3.30253509
8Breast hypoplasia (HP:0003187)3.30186900
9Congenital stationary night blindness (HP:0007642)3.30130066
10Nephronophthisis (HP:0000090)3.17627469
11Abnormality of the ileum (HP:0001549)3.16358489
12Febrile seizures (HP:0002373)3.06121462
13Abnormality of the renal cortex (HP:0011035)3.05570360
14Abnormality of the preputium (HP:0100587)3.03545702
15Type II lissencephaly (HP:0007260)3.02850051
16Abnormal drinking behavior (HP:0030082)2.98237096
17Polydipsia (HP:0001959)2.98237096
18Muscle hypertrophy of the lower extremities (HP:0008968)2.95227958
19Muscle fiber inclusion bodies (HP:0100299)2.90211845
20Medial flaring of the eyebrow (HP:0010747)2.88579279
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.85212658
22Pancreatic fibrosis (HP:0100732)2.83676095
23True hermaphroditism (HP:0010459)2.83562227
24Carpal bone hypoplasia (HP:0001498)2.82843815
25Abnormality of chromosome stability (HP:0003220)2.82091344
26Abnormality of the renal medulla (HP:0100957)2.80195554
27Duplicated collecting system (HP:0000081)2.78100517
28Calf muscle hypertrophy (HP:0008981)2.76520610
29Nemaline bodies (HP:0003798)2.76170721
30Abnormality of the renal collecting system (HP:0004742)2.75257646
31Progressive cerebellar ataxia (HP:0002073)2.74769403
32Microvesicular hepatic steatosis (HP:0001414)2.73073256
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.69655224
34Focal motor seizures (HP:0011153)2.67802311
35Ectopic kidney (HP:0000086)2.67357411
36Pancreatic cysts (HP:0001737)2.66367227
37Acute necrotizing encephalopathy (HP:0006965)2.65671628
38Rough bone trabeculation (HP:0100670)2.58563593
39Type 2 muscle fiber atrophy (HP:0003554)2.57391045
40Bone marrow hypocellularity (HP:0005528)2.56516442
41Genetic anticipation (HP:0003743)2.53937230
42Anterior segment dysgenesis (HP:0007700)2.51031960
43Tubular atrophy (HP:0000092)2.47925542
44Exercise-induced muscle cramps (HP:0003710)2.46765104
45Polyuria (HP:0000103)2.45834678
46Duodenal stenosis (HP:0100867)2.45744041
47Small intestinal stenosis (HP:0012848)2.45744041
48Absent radius (HP:0003974)2.45557143
49Patellar aplasia (HP:0006443)2.45292980
50Rectovaginal fistula (HP:0000143)2.44893374
51Rectal fistula (HP:0100590)2.44893374
52Abolished electroretinogram (ERG) (HP:0000550)2.44461726
53Abnormal spermatogenesis (HP:0008669)2.43457332
54Abnormal rod and cone electroretinograms (HP:0008323)2.42793660
55Hemiparesis (HP:0001269)2.42093242
56Reduced antithrombin III activity (HP:0001976)2.41831729
57Progressive macrocephaly (HP:0004481)2.41709805
58Hyperventilation (HP:0002883)2.41243964
59Facial cleft (HP:0002006)2.39691032
60Absent thumb (HP:0009777)2.37555493
61Clubbing of toes (HP:0100760)2.37511819
62Aplasia/Hypoplasia involving the musculature (HP:0001460)2.34650785
63Cystic liver disease (HP:0006706)2.33915937
64Intestinal fistula (HP:0100819)2.33421467
65Chronic hepatic failure (HP:0100626)2.33119154
66Hypoplasia of the fovea (HP:0007750)2.32750112
67Aplasia/Hypoplasia of the fovea (HP:0008060)2.32750112
68Abnormal lung lobation (HP:0002101)2.31424937
69Attenuation of retinal blood vessels (HP:0007843)2.31399279
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29877085
71Abnormality of alanine metabolism (HP:0010916)2.29877085
72Hyperalaninemia (HP:0003348)2.29877085
73Aplasia/Hypoplasia of the patella (HP:0006498)2.28328361
74Abnormal mitochondria in muscle tissue (HP:0008316)2.28306044
75Pendular nystagmus (HP:0012043)2.27470470
76Gaze-evoked nystagmus (HP:0000640)2.26537553
77Focal seizures (HP:0007359)2.26447455
78Absent forearm bone (HP:0003953)2.25740093
79Aplasia involving forearm bones (HP:0009822)2.25740093
80Gait imbalance (HP:0002141)2.25093806
81Acute encephalopathy (HP:0006846)2.24600924
82Premature graying of hair (HP:0002216)2.23900819
83Hyperglycinuria (HP:0003108)2.22259131
84Supernumerary spleens (HP:0009799)2.21288274
85Large for gestational age (HP:0001520)2.20533421
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18859920
87Myelodysplasia (HP:0002863)2.18568961
88Nephroblastoma (Wilms tumor) (HP:0002667)2.17139821
89Mitochondrial inheritance (HP:0001427)2.16034117
90Abnormal trabecular bone morphology (HP:0100671)2.14919736
91Median cleft lip (HP:0000161)2.14270133
923-Methylglutaconic aciduria (HP:0003535)2.13946532
93Inability to walk (HP:0002540)2.13712250
94Azoospermia (HP:0000027)2.13427965
95Prolonged neonatal jaundice (HP:0006579)2.12103899
96Increased CSF lactate (HP:0002490)2.09363208
97Decreased central vision (HP:0007663)2.09042377
98Prostate neoplasm (HP:0100787)2.07864044
99Preaxial hand polydactyly (HP:0001177)2.07457342
100Embryonal renal neoplasm (HP:0011794)2.07256357
101Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07150857
102Congenital primary aphakia (HP:0007707)2.06747316
103Renal cortical cysts (HP:0000803)2.06238325
104Prolonged QT interval (HP:0001657)2.05860900
105Severe muscular hypotonia (HP:0006829)2.05474431
106Aplastic anemia (HP:0001915)2.05376963
107Abnormal protein glycosylation (HP:0012346)2.03982231
108Abnormal glycosylation (HP:0012345)2.03982231
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03982231
110Abnormal protein N-linked glycosylation (HP:0012347)2.03982231
111Broad-based gait (HP:0002136)2.03932305
112Dialeptic seizures (HP:0011146)2.02271591
113Muscle fiber atrophy (HP:0100295)2.01459102
114Abnormal urine output (HP:0012590)2.01313058
115Bundle branch block (HP:0011710)2.00856158
116Left ventricular hypertrophy (HP:0001712)2.00701580
117Optic disc pallor (HP:0000543)2.00502111
118Dynein arm defect of respiratory motile cilia (HP:0012255)2.00214638
119Absent/shortened dynein arms (HP:0200106)2.00214638
120Congenital hepatic fibrosis (HP:0002612)1.99596092
121Methylmalonic acidemia (HP:0002912)1.98638330
122Atonic seizures (HP:0010819)1.98439085
123Abnormality of DNA repair (HP:0003254)1.97826261
124Agitation (HP:0000713)1.96549635
125Sclerocornea (HP:0000647)1.96496867
126Abnormal biliary tract physiology (HP:0012439)1.96260307
127Bile duct proliferation (HP:0001408)1.96260307
128Nephrogenic diabetes insipidus (HP:0009806)1.95934299
129Keratoconus (HP:0000563)1.95724548
130Increased corneal curvature (HP:0100692)1.95724548
131Intestinal atresia (HP:0011100)1.95091153
132Progressive inability to walk (HP:0002505)1.94926575
133Abnormality of the duodenum (HP:0002246)1.94741931
134Vaginal fistula (HP:0004320)1.93460607
135Hypergonadotropic hypogonadism (HP:0000815)1.92421177
136Ketoacidosis (HP:0001993)1.92021235
137Adrenal hypoplasia (HP:0000835)1.91566754
138Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90882454
139Syncope (HP:0001279)1.90144357
140Degeneration of anterior horn cells (HP:0002398)1.89823870
141Abnormality of the anterior horn cell (HP:0006802)1.89823870
142Sloping forehead (HP:0000340)1.89587742
143Impulsivity (HP:0100710)1.89046649
144Decreased circulating renin level (HP:0003351)1.89043558
145Cerebellar dysplasia (HP:0007033)1.88959446
146Aplasia of the musculature (HP:0100854)1.88785525
147Optic nerve coloboma (HP:0000588)1.88703840
148Anencephaly (HP:0002323)1.88331999
149Hypomagnesemia (HP:0002917)1.87994351
150Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87374511
151Aplasia/hypoplasia of the uterus (HP:0008684)1.86867112
152Lissencephaly (HP:0001339)1.86482290
153Absent speech (HP:0001344)1.85757881
154Abnormality of glycine metabolism (HP:0010895)1.85608999
155Abnormality of serine family amino acid metabolism (HP:0010894)1.85608999
156Postaxial foot polydactyly (HP:0001830)1.85290768
157Congenital, generalized hypertrichosis (HP:0004540)1.85277940
158Triphalangeal thumb (HP:0001199)1.85083412
159Stomach cancer (HP:0012126)1.84002379
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83603404
161Ketosis (HP:0001946)1.83432685
162Epileptic encephalopathy (HP:0200134)1.83416549
163Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82773259
164Pancytopenia (HP:0001876)1.82582888
165Irregular epiphyses (HP:0010582)1.82428989
166Hepatic necrosis (HP:0002605)1.81676976
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.81633970
168Osteomalacia (HP:0002749)1.81082135
169Absence seizures (HP:0002121)1.80525536
170Pachygyria (HP:0001302)1.79832788
171Genital tract atresia (HP:0001827)1.78471028
172Poor head control (HP:0002421)1.77898437
173Microretrognathia (HP:0000308)1.77616651
174Submucous cleft hard palate (HP:0000176)1.75993826
175Abnormal respiratory epithelium morphology (HP:0012253)1.75512066
176Abnormal respiratory motile cilium morphology (HP:0005938)1.75512066
177Stenosis of the external auditory canal (HP:0000402)1.74567668
178Sparse eyelashes (HP:0000653)1.71180478
179Oligohydramnios (HP:0001562)1.70722012
180Short thumb (HP:0009778)1.70375375
181Optic nerve hypoplasia (HP:0000609)1.69988837
182Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.67789318
183Male pseudohermaphroditism (HP:0000037)1.66492514
184Ureteral duplication (HP:0000073)1.66203078
185Abnormality of the fovea (HP:0000493)1.65462980
186Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64850621
187Abnormality of the labia minora (HP:0012880)1.64819457
188Horseshoe kidney (HP:0000085)1.63490158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.78511867
2PLK44.21484538
3ZAK3.97226770
4AKT33.38607114
5STK163.13806405
6PHKG22.97131719
7PHKG12.97131719
8SRPK12.78251991
9IRAK32.77645619
10BUB12.70103948
11EIF2AK32.48913381
12EIF2AK12.47435877
13MKNK22.36508274
14MARK12.12595710
15VRK12.05237375
16MAP4K22.01604747
17EIF2AK21.99456064
18WEE11.96266780
19TAOK31.95235368
20STK38L1.94344875
21MKNK11.93734170
22PRPF4B1.89747269
23DAPK21.84996258
24WNK41.82450799
25PIM21.78681384
26MAP3K141.78448101
27IRAK41.77010745
28OXSR11.75149495
29PAK31.63721727
30PLK31.58988742
31NME21.58871701
32NTRK31.58367376
33MAP3K41.52399712
34CASK1.49234743
35TXK1.48648823
36STK391.44380435
37BMPR21.44132493
38NEK61.43089527
39PLK11.42248665
40MAPKAPK31.40957732
41YES11.36630558
42EPHA21.33593942
43TTK1.28806858
44NTRK21.28464182
45TNIK1.25044223
46PIK3CA1.22916332
47EPHA41.21837179
48PRKCG1.18387268
49MUSK1.16940541
50MAP2K71.15653441
51BRSK21.11753478
52BRAF1.11745017
53ATR1.09527440
54CCNB11.09378189
55ADRBK11.08280824
56ADRBK21.08264386
57* PINK11.08039309
58STK241.07943253
59PRKCE1.06472617
60BCKDK1.03050006
61CDK31.01600115
62SGK20.96824099
63CDC70.96461974
64ERBB30.93460544
65CHEK20.91656460
66CAMK2A0.90491155
67BMPR1B0.90027190
68PTK2B0.89428546
69EPHA30.89292992
70CAMK10.87580312
71TRIM280.87476534
72IKBKB0.87458509
73STK110.82482564
74TEC0.81956695
75CDK70.81468503
76GRK70.81159745
77BRSK10.80980708
78NUAK10.80101627
79ACVR1B0.79682852
80PIM10.79007223
81GRK10.78241004
82AURKB0.77501043
83FGFR20.77493665
84TSSK60.77423173
85CDK80.77047303
86PKN10.76534355
87NEK10.74291614
88NEK20.73891232
89CAMKK20.72225175
90TAOK20.71455622
91MAP2K60.70621988
92CSNK1G20.70597237
93MAP2K40.69279570
94PBK0.68059628
95TIE10.67652986
96SIK30.67433346
97NME10.67419656
98PRKACA0.66731267
99PNCK0.65793361
100CAMK2D0.65245776
101INSRR0.62742518
102PRKG10.60744128
103CSNK2A10.60601340
104NLK0.60524128
105PRKAA10.60047919
106PRKCQ0.59850925
107STK40.59801096
108TLK10.59575868
109TRPM70.58664213
110PIK3CG0.57224171
111MINK10.56824251
112IRAK10.56701738
113CSNK1G10.56373129
114FER0.55627675
115PDK20.54865411
116AURKA0.54288456
117MAPK130.53430476
118PRKAA20.52720703
119MAP3K70.51927997
120ATM0.51876014
121RPS6KA50.51805494
122CHEK10.50563899
123OBSCN0.50297718
124SGK2230.49066556
125SGK4940.49066556
126CHUK0.48564233
127CDK190.48449258
128RPS6KB10.48287027
129PAK60.48067614
130CLK10.47998755
131STK30.45506484
132WNK30.45481485
133CSNK1G30.45467671
134PRKCZ0.45306893
135BCR0.44197208
136CAMK40.44073635
137ARAF0.43988452
138SGK30.43216733
139DYRK20.43184308
140MAPKAPK50.42257429
141IRAK20.42184895
142PRKCI0.40728084
143MAPK70.40436296
144PRKCA0.40336234
145GRK50.38390258
146CAMK2B0.38032904
147NEK90.37809636
148RPS6KL10.37593427
149RPS6KC10.37593427
150PLK20.37432359
151LIMK10.37376975
152MARK30.37149893
153RPS6KA60.36083617
154MAPK120.35441943
155MST40.34817889
156CSNK1A1L0.34680513
157* CDK50.34211762
158* CSNK1A10.32866712
159CDK20.32841845
160PASK0.32093315
161CSNK2A20.31891945
162CDK10.31628515
163PRKACB0.31469469
164ROCK10.31264125
165LYN0.31184468
166CSNK1D0.30730904
167DYRK30.30229411
168MAPK150.30213632

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.16239982
2RNA polymerase_Homo sapiens_hsa030204.11529890
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.82852390
4Proteasome_Homo sapiens_hsa030503.48409048
5Homologous recombination_Homo sapiens_hsa034403.26129085
6Mismatch repair_Homo sapiens_hsa034303.05066160
7Pyrimidine metabolism_Homo sapiens_hsa002402.99297331
8Fanconi anemia pathway_Homo sapiens_hsa034602.90448472
9Base excision repair_Homo sapiens_hsa034102.83789594
10Nicotine addiction_Homo sapiens_hsa050332.55696839
11Basal transcription factors_Homo sapiens_hsa030222.47674107
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47627727
13Cardiac muscle contraction_Homo sapiens_hsa042602.45763506
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.40136506
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.39863952
16Nucleotide excision repair_Homo sapiens_hsa034202.38088485
17Butanoate metabolism_Homo sapiens_hsa006502.36163551
18Spliceosome_Homo sapiens_hsa030402.10690179
19RNA transport_Homo sapiens_hsa030132.05105159
20Ribosome_Homo sapiens_hsa030102.02306106
21Purine metabolism_Homo sapiens_hsa002302.00711747
22Vitamin B6 metabolism_Homo sapiens_hsa007501.98444075
23Nitrogen metabolism_Homo sapiens_hsa009101.97733057
24Non-homologous end-joining_Homo sapiens_hsa034501.95813807
25One carbon pool by folate_Homo sapiens_hsa006701.86877810
26RNA degradation_Homo sapiens_hsa030181.83443260
27Propanoate metabolism_Homo sapiens_hsa006401.83381464
28Insulin secretion_Homo sapiens_hsa049111.80409086
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76816188
30Cell cycle_Homo sapiens_hsa041101.75094717
31Tryptophan metabolism_Homo sapiens_hsa003801.70397257
32Selenocompound metabolism_Homo sapiens_hsa004501.68398761
33Morphine addiction_Homo sapiens_hsa050321.66615223
34GABAergic synapse_Homo sapiens_hsa047271.50861754
35Protein export_Homo sapiens_hsa030601.50367531
36Circadian entrainment_Homo sapiens_hsa047131.49017829
37Alzheimers disease_Homo sapiens_hsa050101.48130889
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39727781
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37964822
40Peroxisome_Homo sapiens_hsa041461.37418840
41Calcium signaling pathway_Homo sapiens_hsa040201.32179708
42Arachidonic acid metabolism_Homo sapiens_hsa005901.32146054
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29935072
44Olfactory transduction_Homo sapiens_hsa047401.29448282
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28451921
46Glutamatergic synapse_Homo sapiens_hsa047241.27266899
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26334629
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25233666
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22955232
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.19966713
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19668127
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15198494
53Amphetamine addiction_Homo sapiens_hsa050311.12946075
54p53 signaling pathway_Homo sapiens_hsa041151.09760831
55Salivary secretion_Homo sapiens_hsa049701.07347421
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05971687
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04656667
58Serotonergic synapse_Homo sapiens_hsa047261.02363345
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00408222
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99705252
61Gastric acid secretion_Homo sapiens_hsa049710.98004397
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97082755
63mRNA surveillance pathway_Homo sapiens_hsa030150.96761236
64Caffeine metabolism_Homo sapiens_hsa002320.95494006
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95431524
66Epstein-Barr virus infection_Homo sapiens_hsa051690.95162333
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.94734410
68Dopaminergic synapse_Homo sapiens_hsa047280.94341461
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93209870
70Chemical carcinogenesis_Homo sapiens_hsa052040.92791073
71Herpes simplex infection_Homo sapiens_hsa051680.92619849
72Dilated cardiomyopathy_Homo sapiens_hsa054140.92533258
73Renin secretion_Homo sapiens_hsa049240.92458184
74Vitamin digestion and absorption_Homo sapiens_hsa049770.91988299
75Huntingtons disease_Homo sapiens_hsa050160.91737700
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91179769
77Fatty acid degradation_Homo sapiens_hsa000710.90855066
78Oxytocin signaling pathway_Homo sapiens_hsa049210.89191195
79ABC transporters_Homo sapiens_hsa020100.89052657
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.88118850
81Ovarian steroidogenesis_Homo sapiens_hsa049130.87971685
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.84854577
83Synaptic vesicle cycle_Homo sapiens_hsa047210.84095785
84Cocaine addiction_Homo sapiens_hsa050300.81603721
85Allograft rejection_Homo sapiens_hsa053300.81298960
86Regulation of autophagy_Homo sapiens_hsa041400.81183731
87Graft-versus-host disease_Homo sapiens_hsa053320.81027739
88Oxidative phosphorylation_Homo sapiens_hsa001900.78926252
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.77151000
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76933758
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76832722
92cAMP signaling pathway_Homo sapiens_hsa040240.76732237
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76501923
94Histidine metabolism_Homo sapiens_hsa003400.75307061
95Rheumatoid arthritis_Homo sapiens_hsa053230.74442248
96Sphingolipid metabolism_Homo sapiens_hsa006000.73496062
97Autoimmune thyroid disease_Homo sapiens_hsa053200.73277734
98Linoleic acid metabolism_Homo sapiens_hsa005910.73183616
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71529007
100Sulfur metabolism_Homo sapiens_hsa009200.69909446
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69584598
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68447944
103Fatty acid metabolism_Homo sapiens_hsa012120.67936624
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67311557
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66448201
106Legionellosis_Homo sapiens_hsa051340.64589265
107Long-term depression_Homo sapiens_hsa047300.64505874
108Glycerolipid metabolism_Homo sapiens_hsa005610.63470386
109Cholinergic synapse_Homo sapiens_hsa047250.62234224
110Systemic lupus erythematosus_Homo sapiens_hsa053220.60549155
111Folate biosynthesis_Homo sapiens_hsa007900.60101305
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59451563
113Asthma_Homo sapiens_hsa053100.59179781
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59045646
115Fructose and mannose metabolism_Homo sapiens_hsa000510.58109499
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58063067
117Glucagon signaling pathway_Homo sapiens_hsa049220.57394194
118Fatty acid biosynthesis_Homo sapiens_hsa000610.57319653
119Other glycan degradation_Homo sapiens_hsa005110.57060360
120Dorso-ventral axis formation_Homo sapiens_hsa043200.57052980
121Measles_Homo sapiens_hsa051620.54816462
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54491800
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53584815
124Metabolic pathways_Homo sapiens_hsa011000.52105538
125* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51810480
126Sulfur relay system_Homo sapiens_hsa041220.51246709
127Parkinsons disease_Homo sapiens_hsa050120.50500512
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49362364
129Fat digestion and absorption_Homo sapiens_hsa049750.49293714
130Circadian rhythm_Homo sapiens_hsa047100.48760614
131Fatty acid elongation_Homo sapiens_hsa000620.43362120
132Type I diabetes mellitus_Homo sapiens_hsa049400.43254323
133Ether lipid metabolism_Homo sapiens_hsa005650.42932174
134Pyruvate metabolism_Homo sapiens_hsa006200.42239107
135Influenza A_Homo sapiens_hsa051640.41913793
136Collecting duct acid secretion_Homo sapiens_hsa049660.40097875
137Galactose metabolism_Homo sapiens_hsa000520.36471866
138Phagosome_Homo sapiens_hsa041450.36324477
139Hematopoietic cell lineage_Homo sapiens_hsa046400.35627330
140Glutathione metabolism_Homo sapiens_hsa004800.34874181
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31878535
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.28733596
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26379383
144Apoptosis_Homo sapiens_hsa042100.24974088
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23650271
146N-Glycan biosynthesis_Homo sapiens_hsa005100.22151230
147Primary immunodeficiency_Homo sapiens_hsa053400.21636842
148Phototransduction_Homo sapiens_hsa047440.21316354
149HTLV-I infection_Homo sapiens_hsa051660.20692936
150Retinol metabolism_Homo sapiens_hsa008300.19678528
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19190045
152Oocyte meiosis_Homo sapiens_hsa041140.18476426
153Leishmaniasis_Homo sapiens_hsa051400.17396856
154Glycosaminoglycan degradation_Homo sapiens_hsa005310.17185316
155Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17170984
156Arginine and proline metabolism_Homo sapiens_hsa003300.17111165
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16451003
158Taste transduction_Homo sapiens_hsa047420.16410751
159Viral carcinogenesis_Homo sapiens_hsa052030.16133129
160Cysteine and methionine metabolism_Homo sapiens_hsa002700.15743903
161Steroid hormone biosynthesis_Homo sapiens_hsa001400.15365279
162beta-Alanine metabolism_Homo sapiens_hsa004100.14800590
163Malaria_Homo sapiens_hsa051440.14722367
164Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13785667
165Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13708982

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