ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.87223709
2	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.85942273
3	regulation of cell communication by electrical coupling (GO:0010649)	3.65656508
4	neuronal action potential propagation (GO:0019227)	3.63457747
5	insulin secretion (GO:0030073)	3.59934114
6	cell communication involved in cardiac conduction (GO:0086065)	3.58932924
7	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.58203932
8	auditory receptor cell differentiation (GO:0042491)	3.55211855
9	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.52760843
10	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.50039548
11	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.47689683
12	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	3.45435844
13	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.44638718
14	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.42677520
15	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	3.40754563
16	glycerophospholipid catabolic process (GO:0046475)	3.39599897
17	macroautophagy (GO:0016236)	3.37485757
18	positive regulation of respiratory burst (GO:0060267)	3.34469225
19	glucocorticoid biosynthetic process (GO:0006704)	3.32793729
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.24374634
21	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	3.23389112
22	peptide hormone processing (GO:0016486)	3.22933187
23	cellular ketone body metabolic process (GO:0046950)	3.22316216
24	endocrine pancreas development (GO:0031018)	3.20839792
25	positive regulation of glycolytic process (GO:0045821)	3.19816859
26	plasma membrane repair (GO:0001778)	3.17377429
27	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.14269405
28	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.10617264
29	synaptic vesicle exocytosis (GO:0016079)	3.08814840
30	sarcomere organization (GO:0045214)	3.05945433
31	positive regulation of insulin secretion (GO:0032024)	3.05126492
32	vocalization behavior (GO:0071625)	3.04596875
33	proline transport (GO:0015824)	3.04159835
34	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.02803215
35	ventricular cardiac muscle cell action potential (GO:0086005)	3.02487996
36	dendritic spine morphogenesis (GO:0060997)	3.01165337
37	neuron cell-cell adhesion (GO:0007158)	3.01152627
38	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.00991615
39	negative regulation of hormone biosynthetic process (GO:0032353)	3.00827669
40	membrane repolarization during action potential (GO:0086011)	3.00671422
41	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.99515026
42	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.99141222
43	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.98746379
44	nitric oxide mediated signal transduction (GO:0007263)	2.96899656
45	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.95502862
46	positive regulation of potassium ion transport (GO:0043268)	2.90742695
47	chemosensory behavior (GO:0007635)	2.90473428
48	synaptic vesicle maturation (GO:0016188)	2.88783544
49	regulation of actin filament-based movement (GO:1903115)	2.88734664
50	calcium-mediated signaling using intracellular calcium source (GO:0035584)	2.88500242
51	toxin metabolic process (GO:0009404)	2.86857429
52	neuronal action potential (GO:0019228)	2.86840009
53	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.85450951
54	thyroid hormone metabolic process (GO:0042403)	2.84942595
55	regulation of relaxation of muscle (GO:1901077)	2.84512567
56	glutamate secretion (GO:0014047)	2.84420722
57	ketone body metabolic process (GO:1902224)	2.82590502
58	respiratory electron transport chain (GO:0022904)	2.82281311
59	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.80736540
60	positive regulation of peptide hormone secretion (GO:0090277)	2.79457147
61	detection of calcium ion (GO:0005513)	2.79099511
62	peptide hormone secretion (GO:0030072)	2.78623841
63	mating behavior (GO:0007617)	2.77008361
64	positive regulation of action potential (GO:0045760)	2.76718087
65	regulation of calcium ion transmembrane transport (GO:1903169)	2.75740438
66	regulation of calcium ion transmembrane transporter activity (GO:1901019)	2.75740438
67	electron transport chain (GO:0022900)	2.74392219
68	cell communication by electrical coupling (GO:0010644)	2.72173166
69	positive regulation of peptide secretion (GO:0002793)	2.71763379
70	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.71753054
71	peptide secretion (GO:0002790)	2.71691969
72	cell migration in hindbrain (GO:0021535)	2.71381754
73	potassium ion export (GO:0071435)	2.71338352
74	inositol phosphate catabolic process (GO:0071545)	2.70300182
75	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.70177997
76	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.70177997
77	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.69995344
78	regulation of cardiac muscle cell contraction (GO:0086004)	2.69531821
79	glandular epithelial cell differentiation (GO:0002067)	2.69480317
80	neuron recognition (GO:0008038)	2.68974798
81	regulation of heart rate by cardiac conduction (GO:0086091)	2.68950052
82	membrane depolarization during action potential (GO:0086010)	2.68404849
83	regulation of membrane repolarization (GO:0060306)	2.67970671
84	negative regulation of hormone metabolic process (GO:0032351)	2.67830124
85	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.67604803
86	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.66799462
87	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	2.66449017
88	phenylpropanoid metabolic process (GO:0009698)	2.64780616
89	epithelial cell fate commitment (GO:0072148)	2.64291829
90	regulation of insulin secretion (GO:0050796)	2.63213368
91	neurofilament cytoskeleton organization (GO:0060052)	2.63139459
92	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.62107946
93	inositol phosphate dephosphorylation (GO:0046855)	2.62107946
94	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.62095332
95	regulation of cardiac muscle contraction (GO:0055117)	2.61252912
96	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.59786382
97	ATP synthesis coupled proton transport (GO:0015986)	2.59786382
98	cellular response to epinephrine stimulus (GO:0071872)	2.59681339
99	positive regulation of calcium ion import (GO:0090280)	2.57629638
100	negative regulation of protein localization to cell surface (GO:2000009)	2.56442526
101	neurotransmitter catabolic process (GO:0042135)	2.56194126
102	regulation of potassium ion transmembrane transport (GO:1901379)	2.55812156
103	regulation of striated muscle contraction (GO:0006942)	2.55614460
104	transcytosis (GO:0045056)	2.54680076
105	regulation of voltage-gated calcium channel activity (GO:1901385)	2.54526386
106	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.54508771
107	response to dietary excess (GO:0002021)	2.54182215
108	cardiac muscle contraction (GO:0060048)	2.53918927
109	parturition (GO:0007567)	2.53617352
110	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.52730516
111	regulation of synaptic vesicle exocytosis (GO:2000300)	2.52667358
112	negative regulation of cation channel activity (GO:2001258)	2.52151943
113	positive regulation of digestive system process (GO:0060456)	2.50888558
114	cardiac conduction (GO:0061337)	2.50058127
115	membrane repolarization (GO:0086009)	2.50025518
116	positive regulation of neurotransmitter transport (GO:0051590)	2.47269112
117	sodium ion export (GO:0071436)	2.46910176
118	regulation of autophagic vacuole assembly (GO:2000785)	2.45955302
119	layer formation in cerebral cortex (GO:0021819)	2.45552895
120	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.45002652
121	cellular potassium ion homeostasis (GO:0030007)	2.44094268
122	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.43802635
123	action potential (GO:0001508)	2.43083578
124	nitric oxide biosynthetic process (GO:0006809)	2.42360923
125	response to epinephrine (GO:0071871)	2.40451976
126	regulation of energy homeostasis (GO:2000505)	2.40388709
127	positive regulation of gluconeogenesis (GO:0045722)	2.39706792
128	neuronal ion channel clustering (GO:0045161)	2.39654870
129	negative regulation of ion transmembrane transporter activity (GO:0032413)	2.39556365
130	regulation of peptide hormone secretion (GO:0090276)	2.39431904
131	multicellular organismal signaling (GO:0035637)	2.39428241
132	cardiac myofibril assembly (GO:0055003)	2.39068274
133	positive regulation of macroautophagy (GO:0016239)	2.38989207
134	axon ensheathment in central nervous system (GO:0032291)	2.38689797
135	central nervous system myelination (GO:0022010)	2.38689797
136	activation of protein kinase A activity (GO:0034199)	2.38443602
137	axonal fasciculation (GO:0007413)	2.38125116
138	glucocorticoid metabolic process (GO:0008211)	2.37826018
139	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.37758346
140	detection of temperature stimulus involved in sensory perception (GO:0050961)	2.37715096
141	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	2.37715096
142	thyroid hormone generation (GO:0006590)	2.37343781
143	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.37212666
144	protein localization to synapse (GO:0035418)	2.36572681
145	type B pancreatic cell development (GO:0003323)	2.36402888
146	peptide transport (GO:0015833)	2.36148022
147	cardiac muscle cell action potential involved in contraction (GO:0086002)	2.35820516
148	detection of temperature stimulus (GO:0016048)	2.35652958
149	regulation of peptide secretion (GO:0002791)	2.35124837
150	positive regulation of sodium ion transport (GO:0010765)	2.33876745
151	locomotory exploration behavior (GO:0035641)	2.33535167
152	L-alpha-amino acid transmembrane transport (GO:1902475)	2.32449428
153	cardiac muscle cell action potential (GO:0086001)	2.31596961
154	establishment of mitochondrion localization (GO:0051654)	2.30512055
155	regulation of cation channel activity (GO:2001257)	2.28807671
156	membrane assembly (GO:0071709)	2.27924924
157	negative regulation of dendrite morphogenesis (GO:0050774)	2.27866109
158	regulation of heart rate (GO:0002027)	2.26628072
159	potassium ion homeostasis (GO:0055075)	2.26171632
160	potassium ion import (GO:0010107)	2.26149673
161	cerebellar Purkinje cell layer development (GO:0021680)	2.25909226
162	regulation of Rac protein signal transduction (GO:0035020)	2.20085725
163	negative regulation of neurological system process (GO:0031645)	2.19847811
164	regulation of vacuole organization (GO:0044088)	2.19297616
165	hormone secretion (GO:0046879)	2.18623126
166	calcium ion import (GO:0070509)	2.17014342
167	neurotransmitter secretion (GO:0007269)	2.17005147
168	sphingomyelin metabolic process (GO:0006684)	2.16956573
169	regulation of protein glycosylation (GO:0060049)	2.15991701
170	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.15468433
171	negative regulation of complement activation (GO:0045916)	2.15327138
172	regulation of hexokinase activity (GO:1903299)	2.14472544
173	regulation of glucokinase activity (GO:0033131)	2.14472544
174	polyol catabolic process (GO:0046174)	2.14092441

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.17146396
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.04970297
3	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.99569086
4	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.89261627
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.76098952
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.66870159
7	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.61572842
8	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.61572842
9	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.57598007
10	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.48195792
11	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.43028378
12	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.37947139
13	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.29260597
14	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.26634590
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.22690986
16	* SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.22133942
17	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.05526879
18	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.99930512
19	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.98787383
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.94808851
21	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.91102842
22	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.90640434
23	DROSHA_22980978_ChIP-Seq_HELA_Human	1.86353607
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.76908157
25	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.68575374
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.66714000
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66204826
28	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.55019119
29	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.51437424
30	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.51077172
31	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.49142489
32	* REST_21632747_ChIP-Seq_MESCs_Mouse	1.46888578
33	* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44257144
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44125039
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43863300
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.42733227
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42483597
38	VDR_22108803_ChIP-Seq_LS180_Human	1.41381148
39	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.40912868
40	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.40734314
41	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.40474460
42	ZNF274_21170338_ChIP-Seq_K562_Hela	1.38646075
43	AHR_22903824_ChIP-Seq_MCF-7_Human	1.38298641
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37288487
45	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.32064922
46	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.31573013
47	* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31093893
48	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.30631276
49	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.28345105
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28067370
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27625400
52	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.25792023
53	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.25589523
54	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24662387
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24380008
56	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.23190285
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23094708
58	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.22355449
59	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.20167752
60	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.19903172
61	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.18824263
62	* P300_19829295_ChIP-Seq_ESCs_Human	1.18272664
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18092376
64	HTT_18923047_ChIP-ChIP_STHdh_Human	1.16563558
65	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16232600
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14108483
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14029965
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13860020
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13562745
70	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.13399422
71	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.13208176
72	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.12371624
73	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.12229493
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.11933103
75	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.11882960
76	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.11310888
77	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.11310888
78	TP53_18474530_ChIP-ChIP_U2OS_Human	1.08367984
79	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.07224938
80	* CDX2_22108803_ChIP-Seq_LS180_Human	1.06406998
81	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.05673647
82	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.05578271
83	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.04722908
84	AR_25329375_ChIP-Seq_VCAP_Human	1.04595437
85	SOX2_20726797_ChIP-Seq_SW620_Human	1.04497479
86	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.04035474
87	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03333863
88	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03267323
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02129466
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01330996
91	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01211122
92	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.01170454
93	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00663931
94	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.00636883
95	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00164023
96	* BCAT_22108803_ChIP-Seq_LS180_Human	0.99739373
97	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98871306
98	ER_23166858_ChIP-Seq_MCF-7_Human	0.98834254
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98348645
100	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.97864437
101	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97830609
102	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.97547976
103	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97300579
104	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.97221163
105	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.96637621
106	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.96303599
107	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96036812
108	* FOXA1_25552417_ChIP-Seq_VCAP_Human	0.95938151
109	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95933193
110	STAT3_23295773_ChIP-Seq_U87_Human	0.95915306
111	TP53_16413492_ChIP-PET_HCT116_Human	0.95422527
112	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.95037633
113	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.94818740
114	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94290633
115	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.94053151
116	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92940759
117	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.92471083
118	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.92076388
119	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.92047223
120	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.90911871
121	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.89623756
122	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.87841158
123	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.87301846
124	AR_19668381_ChIP-Seq_PC3_Human	0.87184151
125	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.87085817
126	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.84302181
127	CTCF_27219007_Chip-Seq_Bcells_Human	0.84227229
128	IGF1R_20145208_ChIP-Seq_DFB_Human	0.84020850
129	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.83958419
130	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.82971738
131	TCF4_23295773_ChIP-Seq_U87_Human	0.82943728
132	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.82615175
133	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.81884466
134	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.81690280
135	* RUNX2_22187159_ChIP-Seq_PCA_Human	0.81663217

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	3.88358955
2	MP0003787_abnormal_imprinting	3.67974671
3	MP0002735_abnormal_chemical_nociception	3.24109998
4	MP0004859_abnormal_synaptic_plasticity	3.23779001
5	MP0000751_myopathy	3.10598343
6	MP0005379_endocrine/exocrine_gland_phen	2.98781669
7	MP0003880_abnormal_central_pattern	2.96047557
8	MP0004270_analgesia	2.82005474
9	MP0001968_abnormal_touch/_nociception	2.73447882
10	MP0003283_abnormal_digestive_organ	2.61885821
11	MP0002163_abnormal_gland_morphology	2.55068776
12	MP0003123_paternal_imprinting	2.51565241
13	MP0002736_abnormal_nociception_after	2.50279503
14	MP0004084_abnormal_cardiac_muscle	2.38853351
15	MP0002734_abnormal_mechanical_nocicepti	2.37797927
16	MP0004036_abnormal_muscle_relaxation	2.28714625
17	MP0003635_abnormal_synaptic_transmissio	2.28016703
18	MP0003195_calcinosis	2.22176058
19	MP0004858_abnormal_nervous_system	2.19420163
20	MP0004215_abnormal_myocardial_fiber	2.15302496
21	MP0002733_abnormal_thermal_nociception	2.09358482
22	MP0001944_abnormal_pancreas_morphology	2.07845019
23	MP0006276_abnormal_autonomic_nervous	2.06203905
24	MP0000749_muscle_degeneration	2.04711462
25	MP0002272_abnormal_nervous_system	2.03754689
26	MP0003329_amyloid_beta_deposits	1.97861566
27	MP0002064_seizures	1.91831821
28	MP0001970_abnormal_pain_threshold	1.91062326
29	MP0009745_abnormal_behavioral_response	1.90621627
30	MP0004043_abnormal_pH_regulation	1.89306681
31	MP0005646_abnormal_pituitary_gland	1.88959084
32	MP0009046_muscle_twitch	1.84215327
33	MP0003646_muscle_fatigue	1.82885026
34	MP0002139_abnormal_hepatobiliary_system	1.81543412
35	MP0002693_abnormal_pancreas_physiology	1.77975346
36	MP0004145_abnormal_muscle_electrophysio	1.76411101
37	MP0002972_abnormal_cardiac_muscle	1.68582170
38	MP0010386_abnormal_urinary_bladder	1.67004294
39	MP0001440_abnormal_grooming_behavior	1.65726582
40	MP0002063_abnormal_learning/memory/cond	1.64228373
41	MP0000747_muscle_weakness	1.63463705
42	MP0004484_altered_response_of	1.61637802
43	MP0001756_abnormal_urination	1.60700868
44	MP0005330_cardiomyopathy	1.58312663
45	MP0001348_abnormal_lacrimal_gland	1.54313807
46	MP0005620_abnormal_muscle_contractility	1.52839225
47	MP0003011_delayed_dark_adaptation	1.51213976
48	MP0003137_abnormal_impulse_conducting	1.51154022
49	MP0002638_abnormal_pupillary_reflex	1.50131749
50	MP0002254_reproductive_system_inflammat	1.50029132
51	MP0001501_abnormal_sleep_pattern	1.48696681
52	MP0002572_abnormal_emotion/affect_behav	1.47563059
53	MP0002078_abnormal_glucose_homeostasis	1.47364323
54	MP0002067_abnormal_sensory_capabilities	1.47312759
55	MP0008775_abnormal_heart_ventricle	1.45530476
56	MP0009780_abnormal_chondrocyte_physiolo	1.45036560
57	MP0001765_abnormal_ion_homeostasis	1.44786444
58	MP0004087_abnormal_muscle_fiber	1.39052880
59	MP0004085_abnormal_heartbeat	1.37972109
60	MP0002184_abnormal_innervation	1.37686933
61	MP0004019_abnormal_vitamin_homeostasis	1.37630923
62	MP0005623_abnormal_meninges_morphology	1.37564231
63	MP0003868_abnormal_feces_composition	1.36545881
64	MP0001486_abnormal_startle_reflex	1.35347798
65	MP0002876_abnormal_thyroid_physiology	1.34182765
66	MP0006138_congestive_heart_failure	1.34060231
67	MP0002909_abnormal_adrenal_gland	1.33817272
68	MP0005645_abnormal_hypothalamus_physiol	1.31760821
69	MP0000003_abnormal_adipose_tissue	1.31718238
70	MP0000920_abnormal_myelination	1.28713764
71	MP0008569_lethality_at_weaning	1.28013577
72	MP0010329_abnormal_lipoprotein_level	1.26627702
73	MP0000462_abnormal_digestive_system	1.25673776
74	MP0000778_abnormal_nervous_system	1.24180883
75	MP0001905_abnormal_dopamine_level	1.24063123
76	MP0001984_abnormal_olfaction	1.23935994
77	MP0005503_abnormal_tendon_morphology	1.21335673
78	MP0008877_abnormal_DNA_methylation	1.20758862
79	MP0003953_abnormal_hormone_level	1.19477743
80	MP0004130_abnormal_muscle_cell	1.19329847
81	MP0001299_abnormal_eye_distance/	1.18119669
82	MP0005448_abnormal_energy_balance	1.17689538
83	MP0002106_abnormal_muscle_physiology	1.13539489
84	MP0000013_abnormal_adipose_tissue	1.12209714
85	MP0004510_myositis	1.11900763
86	MP0004924_abnormal_behavior	1.11743917
87	MP0005386_behavior/neurological_phenoty	1.11743917
88	MP0003122_maternal_imprinting	1.10929759
89	MP0005636_abnormal_mineral_homeostasis	1.09951044
90	MP0004272_abnormal_basement_membrane	1.09767447
91	MP0001986_abnormal_taste_sensitivity	1.09748582
92	MP0000230_abnormal_systemic_arterial	1.09501700
93	MP0003879_abnormal_hair_cell	1.08995662
94	MP0005369_muscle_phenotype	1.08007630
95	MP0003121_genomic_imprinting	1.07487128
96	MP0005332_abnormal_amino_acid	1.06535605
97	MP0000759_abnormal_skeletal_muscle	1.06455729
98	MP0005220_abnormal_exocrine_pancreas	1.06166817
99	MP0000639_abnormal_adrenal_gland	1.05462039
100	MP0005551_abnormal_eye_electrophysiolog	1.05035025
101	MP0001346_abnormal_lacrimal_gland	1.04213024
102	MP0001502_abnormal_circadian_rhythm	1.03107254
103	MP0004782_abnormal_surfactant_physiolog	1.02584201
104	MP0002269_muscular_atrophy	1.01998224
105	MP0001664_abnormal_digestion	0.99842068
106	MP0001485_abnormal_pinna_reflex	0.99797762
107	MP0005385_cardiovascular_system_phenoty	0.99360154
108	MP0001544_abnormal_cardiovascular_syste	0.99360154
109	MP0000955_abnormal_spinal_cord	0.98660079
110	MP0003045_fibrosis	0.98315963
111	MP0004233_abnormal_muscle_weight	0.97905290
112	MP0008004_abnormal_stomach_pH	0.97718667
113	MP0002066_abnormal_motor_capabilities/c	0.97580807
114	MP0001529_abnormal_vocalization	0.97197042
115	MP0005365_abnormal_bile_salt	0.96471511
116	MP0002882_abnormal_neuron_morphology	0.95993312
117	MP0002822_catalepsy	0.95875983
118	MP0003633_abnormal_nervous_system	0.92094677
119	MP0010678_abnormal_skin_adnexa	0.90985756
120	MP0000631_abnormal_neuroendocrine_gland	0.90346705
121	MP0006072_abnormal_retinal_apoptosis	0.89494710
122	MP0005423_abnormal_somatic_nervous	0.88801681
123	MP0002118_abnormal_lipid_homeostasis	0.87802508
124	MP0004811_abnormal_neuron_physiology	0.87576725
125	MP0002108_abnormal_muscle_morphology	0.86622903
126	MP0002295_abnormal_pulmonary_circulatio	0.85691301
127	MP0003634_abnormal_glial_cell	0.84420895
128	MP0005275_abnormal_skin_tensile	0.83905027
129	MP0002557_abnormal_social/conspecific_i	0.83653008
130	MP0002234_abnormal_pharynx_morphology	0.82575761
131	MP0009643_abnormal_urine_homeostasis	0.81754012
132	MP0002090_abnormal_vision	0.81126543
133	MP0000750_abnormal_muscle_regeneration	0.80940116
134	MP0002229_neurodegeneration	0.80894963
135	MP0002971_abnormal_brown_adipose	0.80687605
136	MP0005253_abnormal_eye_physiology	0.79883667
137	MP0003172_abnormal_lysosome_physiology	0.77000721
138	MP0000538_abnormal_urinary_bladder	0.76828989
139	MP0000604_amyloidosis	0.76569998
140	MP0004142_abnormal_muscle_tone	0.76267624
141	MP0001270_distended_abdomen	0.75965633
142	MP0002127_abnormal_cardiovascular_syste	0.75916189
143	MP0004742_abnormal_vestibular_system	0.74029190
144	MP0005670_abnormal_white_adipose	0.73467450
145	MP0010630_abnormal_cardiac_muscle	0.73408556
146	MP0009384_cardiac_valve_regurgitation	0.73045659
147	MP0004885_abnormal_endolymph	0.72979462
148	MP0005165_increased_susceptibility_to	0.71483533
149	MP0010352_gastrointestinal_tract_polyps	0.71263329
150	MP0004147_increased_porphyrin_level	0.69599426
151	MP0010234_abnormal_vibrissa_follicle	0.68764500
152	MP0005535_abnormal_body_temperature	0.68389176

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic seizures (HP:0002173)	4.37364120
2	Hyperinsulinemic hypoglycemia (HP:0000825)	4.33314771
3	Focal motor seizures (HP:0011153)	4.28423464
4	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	4.08694537
5	Sudden death (HP:0001699)	4.08335746
6	Pheochromocytoma (HP:0002666)	4.06257720
7	Right ventricular cardiomyopathy (HP:0011663)	4.04192038
8	Myokymia (HP:0002411)	4.01535143
9	Decreased circulating renin level (HP:0003351)	3.96396648
10	Hyperglycemia (HP:0003074)	3.94923654
11	Hypoglycemic coma (HP:0001325)	3.92029562
12	Abnormality of renin-angiotensin system (HP:0000847)	3.81226958
13	Neuroendocrine neoplasm (HP:0100634)	3.65681870
14	Hyporeflexia of lower limbs (HP:0002600)	3.64503800
15	Ketoacidosis (HP:0001993)	3.61706211
16	Hyperactive renin-angiotensin system (HP:0000841)	3.54719571
17	Double outlet right ventricle (HP:0001719)	3.53194525
18	Congenital malformation of the right heart (HP:0011723)	3.53194525
19	Enlarged penis (HP:0000040)	3.50584859
20	Atonic seizures (HP:0010819)	3.48896396
21	Abnormal pancreas size (HP:0012094)	3.37488661
22	Muscle hypertrophy of the lower extremities (HP:0008968)	3.37433633
23	Late onset (HP:0003584)	3.31125964
24	Calf muscle hypertrophy (HP:0008981)	3.29894755
25	Muscle fiber splitting (HP:0003555)	3.27080756
26	Termporal pattern (HP:0011008)	3.21958558
27	Insidious onset (HP:0003587)	3.21958558
28	Increased circulating renin level (HP:0000848)	3.19660281
29	Large for gestational age (HP:0001520)	3.19240071
30	Insulin-resistant diabetes mellitus (HP:0000831)	3.17106352
31	Focal seizures (HP:0007359)	3.15196036
32	Ulnar claw (HP:0001178)	3.12915264
33	Exercise-induced myalgia (HP:0003738)	3.10446820
34	Metabolic alkalosis (HP:0200114)	3.08790253
35	Myotonia (HP:0002486)	3.07342122
36	Abnormality of the calf musculature (HP:0001430)	3.06614638
37	Ventricular tachycardia (HP:0004756)	3.04452256
38	Hyperphosphatemia (HP:0002905)	3.03212546
39	Ventricular fibrillation (HP:0001663)	3.03128810
40	Syncope (HP:0001279)	3.00797779
41	Palpitations (HP:0001962)	3.00344282
42	Congenital sensorineural hearing impairment (HP:0008527)	2.89725466
43	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.87779376
44	Symptomatic seizures (HP:0011145)	2.86614010
45	Hyperthyroidism (HP:0000836)	2.86437665
46	Acute necrotizing encephalopathy (HP:0006965)	2.82811362
47	Hypokalemia (HP:0002900)	2.79594991
48	Hyperaldosteronism (HP:0000859)	2.79145151
49	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.78516438
50	Agitation (HP:0000713)	2.75639592
51	Atrial fibrillation (HP:0005110)	2.74648484
52	Foot dorsiflexor weakness (HP:0009027)	2.70545726
53	EMG: myopathic abnormalities (HP:0003458)	2.68959215
54	Epileptiform EEG discharges (HP:0011182)	2.68733701
55	EEG with generalized epileptiform discharges (HP:0011198)	2.67218280
56	Hypothermia (HP:0002045)	2.64744698
57	Primary atrial arrhythmia (HP:0001692)	2.63376403
58	Abnormal mitochondria in muscle tissue (HP:0008316)	2.62686548
59	Prolonged QT interval (HP:0001657)	2.61916081
60	Exercise-induced muscle cramps (HP:0003710)	2.59822680
61	Goiter (HP:0000853)	2.59154308
62	Metaphyseal dysplasia (HP:0100255)	2.54041563
63	Action tremor (HP:0002345)	2.51930037
64	Progressive macrocephaly (HP:0004481)	2.51515902
65	Abnormality of the foot musculature (HP:0001436)	2.50681265
66	Supranuclear gaze palsy (HP:0000605)	2.49843012
67	Supraventricular tachycardia (HP:0004755)	2.48777610
68	Increased CSF protein (HP:0002922)	2.48718361
69	Visual hallucinations (HP:0002367)	2.48438314
70	Abnormality of potassium homeostasis (HP:0011042)	2.48350720
71	Supraventricular arrhythmia (HP:0005115)	2.46587080
72	Ventricular arrhythmia (HP:0004308)	2.44964606
73	Febrile seizures (HP:0002373)	2.44332542
74	Hypsarrhythmia (HP:0002521)	2.43978198
75	Abnormality of vitamin B metabolism (HP:0004340)	2.43483345
76	Fetal akinesia sequence (HP:0001989)	2.42502792
77	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.41580138
78	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.41580138
79	Hemiparesis (HP:0001269)	2.40190383
80	Cerebral hemorrhage (HP:0001342)	2.38465994
81	Absence seizures (HP:0002121)	2.38374885
82	Testicular neoplasm (HP:0010788)	2.37607980
83	Bundle branch block (HP:0011710)	2.37483240
84	Abnormality of the pancreatic islet cells (HP:0006476)	2.37382453
85	Abnormality of endocrine pancreas physiology (HP:0012093)	2.37382453
86	Hypercortisolism (HP:0001578)	2.36481348
87	Onion bulb formation (HP:0003383)	2.35487414
88	Neurofibrillary tangles (HP:0002185)	2.33522582
89	Ketosis (HP:0001946)	2.32638092
90	Cerebral inclusion bodies (HP:0100314)	2.31426882
91	Steppage gait (HP:0003376)	2.31043643
92	Hypomagnesemia (HP:0002917)	2.28091949
93	Abnormality of vitamin metabolism (HP:0100508)	2.26442616
94	Difficulty running (HP:0009046)	2.26218866
95	Abnormality of chloride homeostasis (HP:0011422)	2.25002015
96	Proximal tubulopathy (HP:0000114)	2.22485960
97	Adrenal overactivity (HP:0002717)	2.21100673
98	Increased variability in muscle fiber diameter (HP:0003557)	2.20389277
99	Lipoatrophy (HP:0100578)	2.18478055
100	Macroorchidism (HP:0000053)	2.18424875
101	Acute encephalopathy (HP:0006846)	2.16783183
102	Urinary glycosaminoglycan excretion (HP:0003541)	2.13500823
103	Mucopolysacchariduria (HP:0008155)	2.13500823
104	Mitochondrial inheritance (HP:0001427)	2.12570533
105	Dialeptic seizures (HP:0011146)	2.11574897
106	Abnormality of the corticospinal tract (HP:0002492)	2.10989620
107	Myoglobinuria (HP:0002913)	2.10762517
108	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.09686614
109	Abnormality of polysaccharide metabolism (HP:0011012)	2.09686614
110	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.09686614
111	Epileptic encephalopathy (HP:0200134)	2.09539868
112	Abnormality of magnesium homeostasis (HP:0004921)	2.09105459
113	Neoplasm of the peripheral nervous system (HP:0100007)	2.08428309
114	Polydipsia (HP:0001959)	2.07349867
115	Abnormal drinking behavior (HP:0030082)	2.07349867
116	Menstrual irregularities (HP:0000858)	2.07312345
117	Bradycardia (HP:0001662)	2.06092262
118	Hepatoblastoma (HP:0002884)	2.05752392
119	Generalized tonic-clonic seizures (HP:0002069)	2.05372114
120	Tubular atrophy (HP:0000092)	2.03941961
121	Limb dystonia (HP:0002451)	2.02821537
122	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.02641646
123	Muscle stiffness (HP:0003552)	2.01630982
124	Hammertoe (HP:0001765)	2.00802640
125	Hematochezia (HP:0002573)	1.95595700
126	Rapidly progressive (HP:0003678)	1.95246434
127	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.94898017
128	Postural tremor (HP:0002174)	1.94706796
129	Progressive cerebellar ataxia (HP:0002073)	1.93639499
130	Abnormal EKG (HP:0003115)	1.92755600
131	Hyperparathyroidism (HP:0000843)	1.92390710
132	Distal arthrogryposis (HP:0005684)	1.91220115
133	Intention tremor (HP:0002080)	1.91080439
134	Sensory axonal neuropathy (HP:0003390)	1.90255687
135	Increased connective tissue (HP:0009025)	1.89616160
136	Ankle clonus (HP:0011448)	1.89173443
137	Malnutrition (HP:0004395)	1.88295408
138	Hyperkalemia (HP:0002153)	1.87504843
139	Dysmetria (HP:0001310)	1.87259936
140	Progressive neurologic deterioration (HP:0002344)	1.86182337
141	Asymmetric septal hypertrophy (HP:0001670)	1.85905086
142	Anxiety (HP:0000739)	1.85751120
143	Diminished movement (HP:0002374)	1.85526325
144	Hepatocellular necrosis (HP:0001404)	1.85029393
145	Dilated cardiomyopathy (HP:0001644)	1.84907855
146	Neoplasm of the adrenal cortex (HP:0100641)	1.84380030
147	Hypokinesia (HP:0002375)	1.83604263
148	Tachypnea (HP:0002789)	1.83557200
149	Hypoventilation (HP:0002791)	1.82605153
150	Retinal dysplasia (HP:0007973)	1.82160339
151	Atrophic scars (HP:0001075)	1.80804254
152	Glycosuria (HP:0003076)	1.80004367
153	Abnormality of urine glucose concentration (HP:0011016)	1.80004367
154	Peripheral hypomyelination (HP:0007182)	1.79639139
155	Synostosis involving the elbow (HP:0003938)	1.79210325
156	Humeroradial synostosis (HP:0003041)	1.79210325
157	Progressive inability to walk (HP:0002505)	1.77585644
158	Scanning speech (HP:0002168)	1.77414294
159	Vascular calcification (HP:0004934)	1.76860830
160	Papilledema (HP:0001085)	1.76645658
161	Urinary urgency (HP:0000012)	1.74215165
162	Polyphagia (HP:0002591)	1.73700357
163	Abnormality of skeletal muscle fiber size (HP:0012084)	1.73687823
164	Abnormality of pain sensation (HP:0010832)	1.72984616
165	Impaired pain sensation (HP:0007328)	1.72984616
166	Decreased motor nerve conduction velocity (HP:0003431)	1.72107543
167	Growth hormone excess (HP:0000845)	1.70807336
168	Increased CSF lactate (HP:0002490)	1.70341142
169	Hyponatremia (HP:0002902)	1.70119908
170	Abnormality of renal excretion (HP:0011036)	1.69838481
171	Scapular winging (HP:0003691)	1.69556375
172	Akinesia (HP:0002304)	1.69553952
173	Hyperphosphaturia (HP:0003109)	1.68968395
174	Intestinal atresia (HP:0011100)	1.67772068
175	Truncal ataxia (HP:0002078)	1.67689887
176	Hypotension (HP:0002615)	1.66702963
177	Abnormality of the vocal cords (HP:0008777)	1.66196133
178	Delayed gross motor development (HP:0002194)	1.64264776
179	Abnormality of glycolysis (HP:0004366)	1.64125160
180	Increased serum pyruvate (HP:0003542)	1.64125160
181	Heart block (HP:0012722)	1.63619316
182	Spastic gait (HP:0002064)	1.61111662
183	Failure to thrive in infancy (HP:0001531)	1.60834064

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LMTK2	3.14112424
2	STK39	2.88927609
3	NTRK3	2.86895969
4	MAP3K9	2.68424964
5	KSR2	2.36221349
6	PHKG1	2.33139670
7	PHKG2	2.33139670
8	NTRK1	2.30184617
9	WNK3	2.15059084
10	MYLK	2.02425383
11	WNK4	1.96467742
12	LIMK1	1.94824566
13	ARAF	1.91989208
14	GRK5	1.91294848
15	AKT3	1.90584174
16	MINK1	1.88054503
17	ACVR1B	1.87305571
18	MAP3K2	1.80951065
19	TRPM7	1.80191335
20	MAP3K4	1.73497093
21	FGFR3	1.71318483
22	MAP3K12	1.68623344
23	PAK3	1.66920183
24	TTN	1.61597623
25	PIK3CA	1.59000935
26	LATS2	1.58894859
27	GRK1	1.56764760
28	FER	1.55085845
29	STK24	1.54606378
30	NME1	1.53135991
31	MAPKAPK5	1.52554782
32	PTK2B	1.43155323
33	WNK1	1.42115843
34	CAMK2D	1.41614888
35	RET	1.38394380
36	EPHA4	1.37862326
37	NLK	1.34447340
38	PAK6	1.33853301
39	OXSR1	1.31849940
40	MAP2K6	1.31805469
41	ROCK2	1.24733186
42	EPHB1	1.23905456
43	CASK	1.21642545
44	CAMK2A	1.19884406
45	MAP2K7	1.19693179
46	BCR	1.16947269
47	MAP2K1	1.11995698
48	MAP2K4	1.11729696
49	CAMK2B	1.09833425
50	DDR2	1.07879077
51	STK3	1.07683253
52	SGK2	1.07281768
53	DMPK	1.06195031
54	PDK3	1.03876458
55	PDK4	1.03876458
56	PLK2	1.01914628
57	RIPK1	1.01562521
58	MST4	1.01476658
59	PRKAA2	1.01294996
60	PNCK	1.01112732
61	STK11	1.00585518
62	CDK5	1.00253483
63	OBSCN	0.98609782
64	PRKCG	0.98606779
65	PRKCE	0.98477739
66	CAMK2G	0.98370320
67	STK38L	0.97614952
68	CDC42BPA	0.97107442
69	PRKAA1	0.91122704
70	UHMK1	0.90679707
71	ADRBK2	0.90443703
72	MAP3K1	0.88430823
73	CAMK1G	0.86894435
74	CSNK1G1	0.84947431
75	PKN1	0.84470035
76	ROCK1	0.83027150
77	FRK	0.81882088
78	GRK7	0.80752383
79	EPHB2	0.79124452
80	HIPK2	0.78579343
81	MUSK	0.78444631
82	EPHA3	0.76928654
83	MAP2K2	0.76800002
84	SGK3	0.76711968
85	DAPK2	0.75082029
86	CDK14	0.71903591
87	TAOK1	0.71043919
88	ADRBK1	0.70777759
89	CSNK1G3	0.69524317
90	PTK2	0.69109855
91	PDPK1	0.68551603
92	MARK1	0.68500179
93	RIPK4	0.64750968
94	PINK1	0.64170871
95	PRKD1	0.62517480
96	CAMK1	0.62369012
97	CDK19	0.62342036
98	MAP3K7	0.61949376
99	JAK1	0.61665626
100	SGK1	0.61215597
101	CAMKK2	0.61174104
102	SGK223	0.61089021
103	SGK494	0.61089021
104	MAP3K13	0.61073719
105	YES1	0.60791921
106	FGFR4	0.60566826
107	MAP4K2	0.60095667
108	FGR	0.59437711
109	CSNK1G2	0.59430593
110	MET	0.57074442
111	MAPK13	0.56134686
112	TNIK	0.56037196
113	KSR1	0.55707916
114	PDK2	0.55405311
115	CDK18	0.53940400
116	TIE1	0.53684160
117	CDK15	0.52550530
118	ERBB4	0.52039454
119	PRKG1	0.51138287
120	CSNK1A1	0.49950897
121	PRKACA	0.49114327
122	BMPR1B	0.48578852
123	TESK1	0.47894260
124	INSRR	0.47772930
125	PDGFRA	0.46253978
126	PDK1	0.45641775
127	PRKCZ	0.45471110
128	FGFR2	0.45228363
129	PRKACB	0.44952312
130	PRKD3	0.44355795
131	CAMKK1	0.43255159
132	PRKCA	0.42713879
133	NTRK2	0.42601227
134	CDK11A	0.41715137
135	PRKCH	0.41617973
136	DAPK3	0.41343558
137	EPHA2	0.40364130
138	CAMK1D	0.38521165
139	PRKACG	0.38431626
140	TRIM28	0.38258244
141	IRAK1	0.36777049
142	RPS6KA3	0.34049486
143	PRKG2	0.33963540
144	STK4	0.33885314

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.71079428
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.79977680
3	Cardiac muscle contraction_Homo sapiens_hsa04260	2.61970977
4	Parkinsons disease_Homo sapiens_hsa05012	2.44184981
5	Alzheimers disease_Homo sapiens_hsa05010	2.14584006
6	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.09350818
7	Nicotine addiction_Homo sapiens_hsa05033	2.02596344
8	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.97175528
9	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.87775772
10	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.82987438
11	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.79827754
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.70837212
13	GABAergic synapse_Homo sapiens_hsa04727	1.70233278
14	Salivary secretion_Homo sapiens_hsa04970	1.63283304
15	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.61483652
16	Circadian entrainment_Homo sapiens_hsa04713	1.59294371
17	Taste transduction_Homo sapiens_hsa04742	1.57483846
18	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.57237640
19	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.55945584
20	Collecting duct acid secretion_Homo sapiens_hsa04966	1.53600819
21	Circadian rhythm_Homo sapiens_hsa04710	1.49999713
22	Long-term potentiation_Homo sapiens_hsa04720	1.48817659
23	Gastric acid secretion_Homo sapiens_hsa04971	1.47764022
24	Huntingtons disease_Homo sapiens_hsa05016	1.45894550
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.42116304
26	Morphine addiction_Homo sapiens_hsa05032	1.40930073
27	Amphetamine addiction_Homo sapiens_hsa05031	1.40522659
28	Serotonergic synapse_Homo sapiens_hsa04726	1.39086327
29	Glutamatergic synapse_Homo sapiens_hsa04724	1.38595395
30	Olfactory transduction_Homo sapiens_hsa04740	1.37773284
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.37708136
32	Protein export_Homo sapiens_hsa03060	1.37481309
33	Insulin secretion_Homo sapiens_hsa04911	1.30866499
34	Vibrio cholerae infection_Homo sapiens_hsa05110	1.30852387
35	Calcium signaling pathway_Homo sapiens_hsa04020	1.30026084
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29609893
37	Pancreatic secretion_Homo sapiens_hsa04972	1.27969893
38	Sphingolipid metabolism_Homo sapiens_hsa00600	1.25389784
39	Cholinergic synapse_Homo sapiens_hsa04725	1.21531852
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.21021558
41	Renin secretion_Homo sapiens_hsa04924	1.20945130
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.20584360
43	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.14070239
44	Long-term depression_Homo sapiens_hsa04730	1.13556958
45	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.13222508
46	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.12641861
47	Axon guidance_Homo sapiens_hsa04360	1.09758277
48	Type I diabetes mellitus_Homo sapiens_hsa04940	1.09412545
49	Fatty acid degradation_Homo sapiens_hsa00071	1.07968075
50	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.07672075
51	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.03392414
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02421414
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.02375206
54	Gap junction_Homo sapiens_hsa04540	1.01706461
55	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.01610491
56	Cocaine addiction_Homo sapiens_hsa05030	0.98756054
57	GnRH signaling pathway_Homo sapiens_hsa04912	0.97949609
58	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.97906591
59	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.96607765
60	Bile secretion_Homo sapiens_hsa04976	0.96218536
61	Arginine biosynthesis_Homo sapiens_hsa00220	0.94934595
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94856796
63	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.94499820
64	Fatty acid elongation_Homo sapiens_hsa00062	0.94279531
65	Histidine metabolism_Homo sapiens_hsa00340	0.88090976
66	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.88052568
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.87863980
68	Phototransduction_Homo sapiens_hsa04744	0.86734018
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.83825694
70	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.83795736
71	ECM-receptor interaction_Homo sapiens_hsa04512	0.83427705
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83394035
73	Tight junction_Homo sapiens_hsa04530	0.81821449
74	Melanogenesis_Homo sapiens_hsa04916	0.81189314
75	Propanoate metabolism_Homo sapiens_hsa00640	0.80518908
76	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.79802087
77	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.78997908
78	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.78919808
79	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.78679088
80	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.78578043
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.77967623
82	Butanoate metabolism_Homo sapiens_hsa00650	0.75840979
83	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.75168314
84	Estrogen signaling pathway_Homo sapiens_hsa04915	0.74783598
85	ABC transporters_Homo sapiens_hsa02010	0.74525657
86	Other glycan degradation_Homo sapiens_hsa00511	0.74416207
87	Peroxisome_Homo sapiens_hsa04146	0.74298499
88	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73227756
89	Sulfur metabolism_Homo sapiens_hsa00920	0.73100434
90	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.72755602
91	Folate biosynthesis_Homo sapiens_hsa00790	0.72657582
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68744175
93	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.66725585
94	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.66185089
95	Regulation of autophagy_Homo sapiens_hsa04140	0.64917113
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64429103
97	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.64078475
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.62676904
99	PPAR signaling pathway_Homo sapiens_hsa03320	0.62433189
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.62098872
101	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61658936
102	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.60914760
103	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.60498846
104	Focal adhesion_Homo sapiens_hsa04510	0.60308396
105	ErbB signaling pathway_Homo sapiens_hsa04012	0.60221557
106	Lysosome_Homo sapiens_hsa04142	0.58858828
107	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58235421
108	Retinol metabolism_Homo sapiens_hsa00830	0.57059437
109	Ras signaling pathway_Homo sapiens_hsa04014	0.57003218
110	Protein digestion and absorption_Homo sapiens_hsa04974	0.55823240
111	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55234393
112	Linoleic acid metabolism_Homo sapiens_hsa00591	0.54812306
113	Glioma_Homo sapiens_hsa05214	0.53911591
114	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.53580141
115	Melanoma_Homo sapiens_hsa05218	0.52755335
116	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.52612963
117	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.52584760
118	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50551569
119	Renal cell carcinoma_Homo sapiens_hsa05211	0.49950550
120	Rap1 signaling pathway_Homo sapiens_hsa04015	0.49647097
121	Mineral absorption_Homo sapiens_hsa04978	0.49508848
122	Insulin resistance_Homo sapiens_hsa04931	0.48994759
123	Choline metabolism in cancer_Homo sapiens_hsa05231	0.48345512
124	Glucagon signaling pathway_Homo sapiens_hsa04922	0.47348029
125	Insulin signaling pathway_Homo sapiens_hsa04910	0.46523726
126	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.46246400
127	VEGF signaling pathway_Homo sapiens_hsa04370	0.45754248
128	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45510721
129	MAPK signaling pathway_Homo sapiens_hsa04010	0.43862986
130	Endocytosis_Homo sapiens_hsa04144	0.43247158
131	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.41667940
132	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41564034
133	Fatty acid metabolism_Homo sapiens_hsa01212	0.40020247
134	Rheumatoid arthritis_Homo sapiens_hsa05323	0.39963940
135	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38806764
136	Amoebiasis_Homo sapiens_hsa05146	0.37682340
137	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.35971501
138	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35905433
139	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33132439

PARM1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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