PARN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.80817922
2protein localization to kinetochore (GO:0034501)4.66642622
3DNA strand elongation involved in DNA replication (GO:0006271)4.58835326
4DNA replication initiation (GO:0006270)4.45824094
5IMP biosynthetic process (GO:0006188)4.38413171
6mitotic metaphase plate congression (GO:0007080)4.37738613
7DNA strand elongation (GO:0022616)4.34256738
8nucleobase biosynthetic process (GO:0046112)4.32494954
9formation of translation preinitiation complex (GO:0001731)4.31818308
10regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.26733228
11DNA replication checkpoint (GO:0000076)4.11364872
12purine nucleobase biosynthetic process (GO:0009113)4.08237039
13folic acid-containing compound biosynthetic process (GO:0009396)4.07868741
14telomere maintenance via semi-conservative replication (GO:0032201)4.07333215
15metaphase plate congression (GO:0051310)3.97917351
16protein localization to chromosome, centromeric region (GO:0071459)3.95451689
17nuclear pore organization (GO:0006999)3.92854961
18regulation of centriole replication (GO:0046599)3.86883077
19mitotic nuclear envelope disassembly (GO:0007077)3.82707165
20IMP metabolic process (GO:0046040)3.72915977
21DNA replication-dependent nucleosome organization (GO:0034723)3.72292367
22DNA replication-dependent nucleosome assembly (GO:0006335)3.72292367
23telomere maintenance via recombination (GO:0000722)3.71857495
24nuclear pore complex assembly (GO:0051292)3.69777842
25ribosome biogenesis (GO:0042254)3.64406515
26histone H2A acetylation (GO:0043968)3.55747129
27ribosome assembly (GO:0042255)3.55712151
28regulation of spindle organization (GO:0090224)3.50894685
29maturation of 5.8S rRNA (GO:0000460)3.50834651
30nuclear envelope disassembly (GO:0051081)3.50088562
31membrane disassembly (GO:0030397)3.50088562
32CENP-A containing nucleosome assembly (GO:0034080)3.49785759
33double-strand break repair via nonhomologous end joining (GO:0006303)3.49667297
34non-recombinational repair (GO:0000726)3.49667297
35regulation of mitotic spindle checkpoint (GO:1903504)3.49362173
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.49362173
37mitotic recombination (GO:0006312)3.46882239
38establishment of chromosome localization (GO:0051303)3.45483186
39DNA ligation (GO:0006266)3.43419473
40viral mRNA export from host cell nucleus (GO:0046784)3.43401203
41mitotic chromosome condensation (GO:0007076)3.43170156
42positive regulation of chromosome segregation (GO:0051984)3.41081179
43DNA replication-independent nucleosome assembly (GO:0006336)3.40874894
44DNA replication-independent nucleosome organization (GO:0034724)3.40874894
45telomere maintenance via telomere lengthening (GO:0010833)3.39581528
46chromatin remodeling at centromere (GO:0031055)3.35943284
47mitotic sister chromatid cohesion (GO:0007064)3.34526441
48regulation of histone H3-K9 methylation (GO:0051570)3.33691327
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.32368820
50attachment of spindle microtubules to kinetochore (GO:0008608)3.30406101
51tRNA aminoacylation for protein translation (GO:0006418)3.23583467
52DNA duplex unwinding (GO:0032508)3.23262809
53ribosomal small subunit assembly (GO:0000028)3.20673336
54mitotic sister chromatid segregation (GO:0000070)3.20167055
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.18655515
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18655515
57DNA geometric change (GO:0032392)3.16551940
58tRNA aminoacylation (GO:0043039)3.16393759
59amino acid activation (GO:0043038)3.16393759
60regulation of centrosome duplication (GO:0010824)3.16132509
61regulation of translational fidelity (GO:0006450)3.15768446
62folic acid metabolic process (GO:0046655)3.13408060
63negative regulation of chromosome segregation (GO:0051985)3.12247066
64spindle assembly checkpoint (GO:0071173)3.11579039
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11201797
66negative regulation of sister chromatid segregation (GO:0033046)3.11201797
67negative regulation of mitotic sister chromatid separation (GO:2000816)3.11201797
68negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11201797
69peptidyl-arginine omega-N-methylation (GO:0035247)3.10665451
70mitotic spindle assembly checkpoint (GO:0007094)3.10216427
71maturation of SSU-rRNA (GO:0030490)3.08897728
72positive regulation of mitotic sister chromatid separation (GO:1901970)3.08314280
73positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08314280
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08314280
75regulation of sister chromatid cohesion (GO:0007063)3.08241612
76chromatin assembly or disassembly (GO:0006333)3.07912924
77spindle checkpoint (GO:0031577)3.07137186
78histone H4-K12 acetylation (GO:0043983)3.06172836
79DNA deamination (GO:0045006)3.05330875
80regulation of centrosome cycle (GO:0046605)3.03649211
81negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02476458
82regulation of nuclear cell cycle DNA replication (GO:0033262)3.02166161
83mitochondrial RNA metabolic process (GO:0000959)3.02006660
84establishment of integrated proviral latency (GO:0075713)3.01196418
85regulation of mitotic spindle organization (GO:0060236)3.00069199
86DNA topological change (GO:0006265)2.99629878
87intra-S DNA damage checkpoint (GO:0031573)2.99209512
88mismatch repair (GO:0006298)2.98877505
89somatic recombination of immunoglobulin gene segments (GO:0016447)2.98019882
90pteridine-containing compound biosynthetic process (GO:0042559)2.97545149
91DNA catabolic process, exonucleolytic (GO:0000738)2.96695425
92regulation of helicase activity (GO:0051095)2.96489493
93somatic diversification of immunoglobulins (GO:0016445)2.95175889
94histone exchange (GO:0043486)2.94522015
95kinetochore organization (GO:0051383)2.94424637
96somatic cell DNA recombination (GO:0016444)2.94043919
97somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.94043919
98regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94016963
99regulation of double-strand break repair via homologous recombination (GO:0010569)2.93407252
100somatic diversification of immune receptors (GO:0002200)2.92321254
101synapsis (GO:0007129)2.92170928
102translesion synthesis (GO:0019985)2.91552009
103negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91000185
104meiotic chromosome segregation (GO:0045132)2.89659581
105regulation of DNA damage checkpoint (GO:2000001)2.89546185
106regulation of mitotic sister chromatid separation (GO:0010965)2.89496071
107protein localization to chromosome (GO:0034502)2.89195377
108establishment of viral latency (GO:0019043)2.88423148
109positive regulation of cell cycle checkpoint (GO:1901978)2.88065941
110* RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87853132
111regulation of chromosome segregation (GO:0051983)2.87518731
112maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87052047
113spliceosomal snRNP assembly (GO:0000387)2.86985733
114positive regulation of histone H3-K4 methylation (GO:0051571)2.86917405
115regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85781468
116mitotic spindle checkpoint (GO:0071174)2.85023396
117chromosome segregation (GO:0007059)2.84930372
118somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.84247377
119somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.84247377
120isotype switching (GO:0045190)2.84247377
121deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83536565
122telomere organization (GO:0032200)2.83248309
123sister chromatid segregation (GO:0000819)2.81991775
124kinetochore assembly (GO:0051382)2.81707130
125telomere maintenance (GO:0000723)2.81067196
126histone arginine methylation (GO:0034969)2.80938951
127RNA export from nucleus (GO:0006405)2.80713471
128ribonucleoprotein complex biogenesis (GO:0022613)2.79840464
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79616895
130mRNA export from nucleus (GO:0006406)2.79217958
131ATP-dependent chromatin remodeling (GO:0043044)2.79130529
132histone H2A monoubiquitination (GO:0035518)2.76577349
133rRNA processing (GO:0006364)2.76549979
134negative regulation of histone methylation (GO:0031061)2.76475246
135pore complex assembly (GO:0046931)2.76400642
136regulation of sister chromatid segregation (GO:0033045)2.75066006
137regulation of mitotic sister chromatid segregation (GO:0033047)2.75066006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.28560550
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.08061724
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.96598006
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56410935
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24857103
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.24762799
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97126178
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70305611
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.67201671
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59669619
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57230389
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.54285248
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48559095
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.38948302
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26718877
16AR_21909140_ChIP-Seq_LNCAP_Human2.24585166
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24548780
18VDR_23849224_ChIP-Seq_CD4+_Human2.23144592
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.23066397
20FOXP3_21729870_ChIP-Seq_TREG_Human2.23021106
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20764905
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.20298325
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18997381
24XRN2_22483619_ChIP-Seq_HELA_Human2.18966596
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.12618372
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06087498
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.00457461
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99403627
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.98205322
30CIITA_25753668_ChIP-Seq_RAJI_Human1.98200705
31MYC_22102868_ChIP-Seq_BL_Human1.93924465
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93179843
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90413591
34* GABP_19822575_ChIP-Seq_HepG2_Human1.89747879
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89423635
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88542961
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84965400
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77905287
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75995528
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72559137
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70842676
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67816583
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.66349200
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63442527
45TTF2_22483619_ChIP-Seq_HELA_Human1.62759778
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62274689
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61588081
48KDM5A_27292631_Chip-Seq_BREAST_Human1.61538341
49ELK1_19687146_ChIP-ChIP_HELA_Human1.58821070
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55483407
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48625932
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.48409302
53DCP1A_22483619_ChIP-Seq_HELA_Human1.45239154
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42419082
55* SRF_21415370_ChIP-Seq_HL-1_Mouse1.39922073
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39053581
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36649748
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33290549
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29377120
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29259702
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28949914
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24928008
63* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22060661
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21131548
65IRF1_19129219_ChIP-ChIP_H3396_Human1.19684893
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18735104
67TFEB_21752829_ChIP-Seq_HELA_Human1.18063861
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15280002
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14196055
70SCL_19346495_ChIP-Seq_HPC-7_Human1.13297156
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12889593
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11121891
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10846056
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.08219693
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08073703
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06684383
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03912393
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03476130
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01707741
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01032193
81* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00166157
82MYB_26560356_Chip-Seq_TH2_Human0.98674077
83MYC_18940864_ChIP-ChIP_HL60_Human0.97837322
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97643243
85RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94836334
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92398830
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92305100
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90449246
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89821113
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88361287
91VDR_21846776_ChIP-Seq_THP-1_Human0.87324539
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86970476
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85215186
94SALL1_21062744_ChIP-ChIP_HESCs_Human0.84557717
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.83777117
96MYB_26560356_Chip-Seq_TH1_Human0.83116505
97SPI1_23547873_ChIP-Seq_NB4_Human0.82133927
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80832382
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80269238
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80269238
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80269238
102NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78848103
103TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77788260
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77612339
105GATA1_22025678_ChIP-Seq_K562_Human0.77460044
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76832240
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76754876
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.76521432
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76262325
110* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74020086
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69669243
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69666998
113ZNF274_21170338_ChIP-Seq_K562_Hela0.69390716
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.68575461
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68320912
116CHD1_26751641_Chip-Seq_LNCaP_Human0.67004186
117* ELK1_22589737_ChIP-Seq_MCF10A_Human0.65886440
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.65301145
119ELF5_23300383_ChIP-Seq_T47D_Human0.64913774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.94957413
2MP0010094_abnormal_chromosome_stability4.39075862
3MP0003111_abnormal_nucleus_morphology4.13312853
4MP0004957_abnormal_blastocyst_morpholog3.82610013
5MP0008057_abnormal_DNA_replication3.60227492
6MP0003077_abnormal_cell_cycle3.50707182
7MP0008058_abnormal_DNA_repair3.43698265
8MP0002396_abnormal_hematopoietic_system3.28032384
9MP0008007_abnormal_cellular_replicative2.88997951
10MP0008877_abnormal_DNA_methylation2.77755181
11MP0000566_synostosis2.43794055
12MP0006292_abnormal_olfactory_placode2.30544449
13MP0003123_paternal_imprinting2.24355204
14MP0008932_abnormal_embryonic_tissue2.12007660
15MP0000350_abnormal_cell_proliferation2.07452233
16MP0001730_embryonic_growth_arrest2.01732253
17MP0006035_abnormal_mitochondrial_morpho2.00996029
18MP0010352_gastrointestinal_tract_polyps2.00118578
19MP0003121_genomic_imprinting1.85082501
20MP0003786_premature_aging1.72716330
21MP0004147_increased_porphyrin_level1.65443702
22MP0000490_abnormal_crypts_of1.64045237
23MP0005380_embryogenesis_phenotype1.63951047
24MP0001672_abnormal_embryogenesis/_devel1.63951047
25MP0004808_abnormal_hematopoietic_stem1.52102924
26MP0010307_abnormal_tumor_latency1.51906415
27MP0002084_abnormal_developmental_patter1.51530279
28MP0001697_abnormal_embryo_size1.51421893
29MP0003984_embryonic_growth_retardation1.50923596
30MP0002088_abnormal_embryonic_growth/wei1.42370220
31MP0002080_prenatal_lethality1.40963466
32MP0001853_heart_inflammation1.40356896
33MP0002085_abnormal_embryonic_tissue1.39911763
34MP0009697_abnormal_copulation1.39572997
35MP0000313_abnormal_cell_death1.38974039
36MP0005257_abnormal_intraocular_pressure1.38461181
37MP0002019_abnormal_tumor_incidence1.38230087
38MP0001293_anophthalmia1.37301609
39MP0004133_heterotaxia1.35082671
40MP0003806_abnormal_nucleotide_metabolis1.34546793
41MP0002254_reproductive_system_inflammat1.34069202
42MP0001545_abnormal_hematopoietic_system1.33444676
43MP0005397_hematopoietic_system_phenotyp1.33444676
44MP0002086_abnormal_extraembryonic_tissu1.29917239
45MP0002210_abnormal_sex_determination1.27499558
46MP0002009_preneoplasia1.26946800
47MP0001849_ear_inflammation1.26905447
48MP0002166_altered_tumor_susceptibility1.26825890
49MP0003186_abnormal_redox_activity1.26526308
50MP0002006_tumorigenesis1.25832093
51MP0003763_abnormal_thymus_physiology1.25396810
52MP0003890_abnormal_embryonic-extraembry1.24770030
53MP0004233_abnormal_muscle_weight1.24138075
54MP0010030_abnormal_orbit_morphology1.24051798
55MP0001346_abnormal_lacrimal_gland1.20464195
56MP0002163_abnormal_gland_morphology1.16987232
57MP0001145_abnormal_male_reproductive1.16745849
58MP0001119_abnormal_female_reproductive1.13226433
59MP0000653_abnormal_sex_gland1.12222204
60MP0003787_abnormal_imprinting1.11092239
61MP0002877_abnormal_melanocyte_morpholog1.09800743
62MP0004197_abnormal_fetal_growth/weight/1.09360873
63MP0005075_abnormal_melanosome_morpholog1.02535173
64MP0001929_abnormal_gametogenesis1.02284604
65MP0000703_abnormal_thymus_morphology1.01069827
66MP0003119_abnormal_digestive_system0.99448943
67MP0005621_abnormal_cell_physiology0.99406097
68MP0003718_maternal_effect0.97406554
69MP0000372_irregular_coat_pigmentation0.96013270
70MP0002398_abnormal_bone_marrow0.95815530
71MP0005384_cellular_phenotype0.94282200
72MP0009672_abnormal_birth_weight0.93834684
73MP0004264_abnormal_extraembryonic_tissu0.91581694
74MP0003221_abnormal_cardiomyocyte_apopto0.91512101
75MP0003941_abnormal_skin_development0.90048742
76MP0000689_abnormal_spleen_morphology0.89553130
77MP0001919_abnormal_reproductive_system0.88721473
78MP0001661_extended_life_span0.88713688
79MP0006036_abnormal_mitochondrial_physio0.86768705
80MP0003943_abnormal_hepatobiliary_system0.85891153
81MP0002722_abnormal_immune_system0.85764320
82MP0009703_decreased_birth_body0.85540175
83MP0005408_hypopigmentation0.83193541
84MP0003937_abnormal_limbs/digits/tail_de0.82802481
85MP0005023_abnormal_wound_healing0.81904472
86MP0003699_abnormal_female_reproductive0.80803039
87MP0005501_abnormal_skin_physiology0.80198487
88MP0001800_abnormal_humoral_immune0.79446361
89MP0000428_abnormal_craniofacial_morphol0.79040453
90MP0006054_spinal_hemorrhage0.78380478
91MP0001835_abnormal_antigen_presentation0.77646890
92MP0005389_reproductive_system_phenotype0.77365127
93MP0000537_abnormal_urethra_morphology0.76869331
94MP0003698_abnormal_male_reproductive0.76642928
95MP0001915_intracranial_hemorrhage0.76097883
96MP0005379_endocrine/exocrine_gland_phen0.75422864
97MP0005395_other_phenotype0.74760307
98MP0001881_abnormal_mammary_gland0.73911044
99MP0003567_abnormal_fetal_cardiomyocyte0.73153764
100MP0009333_abnormal_splenocyte_physiolog0.70099702
101MP0000639_abnormal_adrenal_gland0.69618229
102MP0002938_white_spotting0.69351931
103MP0001286_abnormal_eye_development0.69137247
104MP0002429_abnormal_blood_cell0.68627374
105MP0005220_abnormal_exocrine_pancreas0.68254614
106MP0002111_abnormal_tail_morphology0.67770729
107MP0002092_abnormal_eye_morphology0.67582767
108MP0001764_abnormal_homeostasis0.67413144
109MP0003566_abnormal_cell_adhesion0.67229612
110MP0005365_abnormal_bile_salt0.66097769
111MP0000003_abnormal_adipose_tissue0.65479177
112MP0001727_abnormal_embryo_implantation0.65334170
113MP0001243_abnormal_dermal_layer0.64842122
114MP0002160_abnormal_reproductive_system0.63452571
115MP0008995_early_reproductive_senescence0.62809259
116MP0000358_abnormal_cell_content/0.62360042
117MP0001986_abnormal_taste_sensitivity0.62274780
118MP0002161_abnormal_fertility/fecundity0.61760592
119MP0000678_abnormal_parathyroid_gland0.61094114
120MP0005076_abnormal_cell_differentiation0.61065516
121MP0003283_abnormal_digestive_organ0.60512116
122MP0008260_abnormal_autophagy0.59661324
123MP0000627_abnormal_mammary_gland0.59366809
124MP0000598_abnormal_liver_morphology0.59074020
125MP0003656_abnormal_erythrocyte_physiolo0.58215449
126MP0002075_abnormal_coat/hair_pigmentati0.58015151
127MP0000477_abnormal_intestine_morphology0.57606988
128MP0002420_abnormal_adaptive_immunity0.57564741
129MP0000716_abnormal_immune_system0.57082708
130MP0000015_abnormal_ear_pigmentation0.56709985
131MP0002723_abnormal_immune_serum0.56636919
132MP0002452_abnormal_antigen_presenting0.56262416
133MP0001819_abnormal_immune_cell0.54894392

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.40751410
2Microvesicular hepatic steatosis (HP:0001414)4.18156693
3Breast hypoplasia (HP:0003187)4.09827870
4Aplastic anemia (HP:0001915)3.75433455
5Colon cancer (HP:0003003)3.58821711
6Chromsome breakage (HP:0040012)3.41226825
7Oral leukoplakia (HP:0002745)3.40348135
8Ependymoma (HP:0002888)3.31861322
9Medulloblastoma (HP:0002885)3.17470669
10Type I transferrin isoform profile (HP:0003642)3.17165050
11Abnormality of the fingertips (HP:0001211)3.17119904
12Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.13766337
13Abnormal protein N-linked glycosylation (HP:0012347)3.13766337
14Abnormal protein glycosylation (HP:0012346)3.13766337
15Abnormal glycosylation (HP:0012345)3.13766337
16Impulsivity (HP:0100710)3.13110063
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09335243
18Embryonal renal neoplasm (HP:0011794)3.07644758
19Patellar aplasia (HP:0006443)3.04051109
20Clubbing of toes (HP:0100760)3.00994643
21Nephroblastoma (Wilms tumor) (HP:0002667)2.98778209
22Premature ovarian failure (HP:0008209)2.90119572
23Pancreatic fibrosis (HP:0100732)2.76785698
24Myelodysplasia (HP:0002863)2.70493310
25Duplicated collecting system (HP:0000081)2.68620880
26Aplasia/Hypoplasia of the patella (HP:0006498)2.67383067
27Progressive inability to walk (HP:0002505)2.62345740
28Neoplasm of the oral cavity (HP:0100649)2.61127792
29Rough bone trabeculation (HP:0100670)2.60639557
30Volvulus (HP:0002580)2.58778478
31Abnormality of the anterior horn cell (HP:0006802)2.56359584
32Degeneration of anterior horn cells (HP:0002398)2.56359584
3311 pairs of ribs (HP:0000878)2.55332388
34Abnormality of the labia minora (HP:0012880)2.53965589
35Abnormality of chromosome stability (HP:0003220)2.48420864
36Premature graying of hair (HP:0002216)2.44420167
37Shawl scrotum (HP:0000049)2.43649803
38Abnormality of the preputium (HP:0100587)2.42131803
39Sloping forehead (HP:0000340)2.39659335
40Reticulocytopenia (HP:0001896)2.35300734
41Abnormality of the renal collecting system (HP:0004742)2.35039684
42Secondary amenorrhea (HP:0000869)2.34265806
43Optic nerve coloboma (HP:0000588)2.32058522
44Prominent nose (HP:0000448)2.31712027
45Papillary thyroid carcinoma (HP:0002895)2.31224810
46Absent radius (HP:0003974)2.29869840
47Astrocytoma (HP:0009592)2.28975249
48Abnormality of the astrocytes (HP:0100707)2.28975249
49Bone marrow hypocellularity (HP:0005528)2.28458534
50Pendular nystagmus (HP:0012043)2.27644612
51Rhabdomyosarcoma (HP:0002859)2.24165758
52Hypoplasia of the pons (HP:0012110)2.22905491
53Agnosia (HP:0010524)2.22049614
54Abnormality of the columella (HP:0009929)2.20191027
55Selective tooth agenesis (HP:0001592)2.20071474
56Acute myeloid leukemia (HP:0004808)2.18016393
57Hypergonadotropic hypogonadism (HP:0000815)2.17643378
58Glioma (HP:0009733)2.14754170
59Meckel diverticulum (HP:0002245)2.14498572
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14076083
61Abnormality of alanine metabolism (HP:0010916)2.14076083
62Hyperalaninemia (HP:0003348)2.14076083
63Megaloblastic anemia (HP:0001889)2.13011292
64Abnormal trabecular bone morphology (HP:0100671)2.12135294
65Homocystinuria (HP:0002156)2.11354373
66Abnormality of homocysteine metabolism (HP:0010919)2.11354373
67Overlapping toe (HP:0001845)2.10972623
68Increased serum lactate (HP:0002151)2.09318534
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.08852868
70Abnormality of the pons (HP:0007361)2.08652974
71Ectopic kidney (HP:0000086)2.06992075
72Septo-optic dysplasia (HP:0100842)2.06954095
73Abnormality of the ileum (HP:0001549)2.05865824
74Progressive muscle weakness (HP:0003323)2.05702796
75IgG deficiency (HP:0004315)2.05134380
76Thrombocytosis (HP:0001894)2.04099420
77Aplasia involving forearm bones (HP:0009822)2.03309877
78Absent forearm bone (HP:0003953)2.03309877
79Reduced antithrombin III activity (HP:0001976)2.03204288
80Facial cleft (HP:0002006)2.01896185
81Abdominal situs inversus (HP:0003363)2.01597277
82Abnormality of abdominal situs (HP:0011620)2.01597277
83Agammaglobulinemia (HP:0004432)2.00741538
84Duodenal stenosis (HP:0100867)1.99244989
85Small intestinal stenosis (HP:0012848)1.99244989
86Gonadotropin excess (HP:0000837)1.98948916
87IgM deficiency (HP:0002850)1.98855566
88IgA deficiency (HP:0002720)1.96876149
89Lymphoma (HP:0002665)1.96271852
90Neutropenia (HP:0001875)1.94965860
91Combined immunodeficiency (HP:0005387)1.94311766
92Neoplasm of the pancreas (HP:0002894)1.93438588
93Cerebral hypomyelination (HP:0006808)1.91462396
94Abnormality of serum amino acid levels (HP:0003112)1.90860074
95Microretrognathia (HP:0000308)1.90840042
96Abnormality of B cell number (HP:0010975)1.90477266
97Slender long bone (HP:0003100)1.89131115
98Carpal bone hypoplasia (HP:0001498)1.86908135
99Neoplasm of striated muscle (HP:0009728)1.86307696
100Abnormality of the heme biosynthetic pathway (HP:0010472)1.85769810
101Prominent metopic ridge (HP:0005487)1.85740012
102B lymphocytopenia (HP:0010976)1.85083349
103Self-mutilation (HP:0000742)1.85074112
104Abnormality of the metopic suture (HP:0005556)1.84367620
105Abnormal spermatogenesis (HP:0008669)1.83939025
106Abnormality of the carotid arteries (HP:0005344)1.83572370
107Choanal atresia (HP:0000453)1.83396708
108Basal cell carcinoma (HP:0002671)1.82729041
109Chronic hepatic failure (HP:0100626)1.82725997
110Cleft eyelid (HP:0000625)1.82337618
111Impaired proprioception (HP:0010831)1.81897319
112Increased nuchal translucency (HP:0010880)1.81741533
113Neoplasm of the colon (HP:0100273)1.80958365
114Abnormality of the duodenum (HP:0002246)1.80781859
115Squamous cell carcinoma (HP:0002860)1.80699204
116Methylmalonic acidemia (HP:0002912)1.80585701
117Abnormality of pyrimidine metabolism (HP:0004353)1.80194188
118Abnormality of glycolysis (HP:0004366)1.78719177
119CNS hypomyelination (HP:0003429)1.78407132
120Missing ribs (HP:0000921)1.76496566
121Abnormal lung lobation (HP:0002101)1.76406809
122Cellular immunodeficiency (HP:0005374)1.75887355
123Horseshoe kidney (HP:0000085)1.74405768
124Abnormal number of erythroid precursors (HP:0012131)1.74121564
125Aseptic necrosis (HP:0010885)1.74059026
126Amaurosis fugax (HP:0100576)1.73684303
127High pitched voice (HP:0001620)1.72916634
128Progressive external ophthalmoplegia (HP:0000590)1.72427142
129Posterior subcapsular cataract (HP:0007787)1.72384187
130Panhypogammaglobulinemia (HP:0003139)1.72161945
131Pancytopenia (HP:0001876)1.71776744
132Preaxial hand polydactyly (HP:0001177)1.70807012
133Cafe-au-lait spot (HP:0000957)1.70472376
134Leukopenia (HP:0001882)1.70326429
135Abnormality of methionine metabolism (HP:0010901)1.69779189
136Median cleft lip (HP:0000161)1.68933932
137Long eyelashes (HP:0000527)1.68509792
138Triphalangeal thumb (HP:0001199)1.68208354
139Abnormality of DNA repair (HP:0003254)1.68137378
140Cystic liver disease (HP:0006706)1.67607774
141Poikiloderma (HP:0001029)1.67057019
142Multiple enchondromatosis (HP:0005701)1.66860247
143Occipital encephalocele (HP:0002085)1.66844867
144Increased serum pyruvate (HP:0003542)1.66725780
145Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.65868732
146Lipid accumulation in hepatocytes (HP:0006561)1.65848078
147Abnormal number of incisors (HP:0011064)1.65111963
148Hyperglycinemia (HP:0002154)1.64547876
149Absent thumb (HP:0009777)1.64256936
150Abnormality of cells of the erythroid lineage (HP:0012130)1.64195357
151Ureteral duplication (HP:0000073)1.63377088
152Embryonal neoplasm (HP:0002898)1.62829231
153Entropion (HP:0000621)1.62297997
154Acanthocytosis (HP:0001927)1.61976305
155T lymphocytopenia (HP:0005403)1.60034826
156Hyperglycinuria (HP:0003108)1.57570674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.29179651
2WEE13.24806815
3BUB13.24083633
4PBK3.10930080
5SRPK13.00566179
6PLK42.85614773
7MST42.83170569
8CDK82.82780755
9EEF2K2.69803767
10ACVR1B2.50840877
11NEK22.46544733
12FLT32.25144792
13BRSK22.22500864
14CDK122.16772146
15TTK2.12062019
16NUAK12.09757087
17PASK2.08226643
18CDK72.06772038
19VRK22.04829768
20NEK11.98097692
21RPS6KB21.97403515
22PDK21.93927971
23EIF2AK11.86627461
24ATR1.84276056
25MKNK11.82602579
26TSSK61.80601481
27TGFBR11.70402666
28PLK11.60574184
29VRK11.58839919
30STK101.57518329
31EIF2AK31.55150116
32BRSK11.54464640
33CHEK21.53398741
34BRD41.52121985
35AURKB1.42197183
36MKNK21.32250509
37RPS6KA41.31089865
38JAK31.30321743
39CHEK11.25186596
40CDK41.24520032
41MAPKAPK31.24199576
42DYRK31.23604976
43PIM11.15092824
44MELK1.15040830
45PLK31.14676542
46STK161.13645481
47TAF11.13006008
48CLK11.03592047
49PAK41.03432319
50CCNB11.02536723
51CDK191.02235955
52STK391.01453222
53ATM1.00009187
54MAP4K10.98032677
55TXK0.97389830
56CDK20.96799117
57TNIK0.92832186
58WNK40.92439032
59MAP3K100.91255585
60TRIM280.87271781
61SCYL20.86734219
62MAP3K80.84967942
63AURKA0.81931525
64NLK0.81907347
65STK40.77523148
66IRAK10.75040360
67CSF1R0.74000053
68KIT0.70614890
69CSNK2A20.67653414
70MAPK110.65815517
71TEC0.65487146
72CDK90.65413823
73MAPK150.65281122
74AKT20.65082863
75BTK0.64366341
76CDK10.64257633
77NEK60.62767281
78MAP3K60.62631926
79TESK20.62413807
80BCKDK0.61446395
81MET0.61309696
82STK38L0.61089977
83NME20.60142082
84NEK90.59431472
85EPHA20.59033051
86MTOR0.58629821
87ITK0.56005050
88TAOK30.55228378
89STK30.54292879
90BMPR1B0.53927577
91CDK60.53327309
92SIK30.51550542
93LATS10.50703929
94TNK20.50697414
95ZAK0.49137803
96MAP4K20.47485956
97HIPK20.47131955
98CSNK2A10.46473493
99TLK10.46204714
100ALK0.45068712
101RAF10.44573266
102CHUK0.44178168
103EIF2AK20.43839955
104MAPK140.43015374
105RPS6KA50.41710307
106MAPKAPK50.39685199
107SMG10.38884344
108CSNK1E0.37946044
109FGFR40.36594757
110BCR0.36575208
111MAP3K140.36459169
112RPS6KB10.34820689
113MAPK30.34635424
114PRKCI0.34468823
115AKT30.33777675
116MAP2K30.32988463
117FRK0.32353273
118TAOK10.29711308
119BRAF0.29400301
120ERBB40.29099959
121MAPK10.29096244
122GSK3B0.28637192
123PRKDC0.27587692
124ZAP700.27490357
125AKT10.27259372
126MAP3K40.25787806
127CDK30.25469419
128PAK10.25242435
129* MAPKAPK20.24702822
130LATS20.24601954
131PRKCQ0.23995090
132OXSR10.22936341

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.92140644
2Mismatch repair_Homo sapiens_hsa034304.35299818
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.48015446
4Spliceosome_Homo sapiens_hsa030403.16032596
5Base excision repair_Homo sapiens_hsa034103.07134855
6Cell cycle_Homo sapiens_hsa041103.01744508
7RNA transport_Homo sapiens_hsa030132.94934131
8Homologous recombination_Homo sapiens_hsa034402.92234375
9Basal transcription factors_Homo sapiens_hsa030222.79263980
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.76620742
11RNA polymerase_Homo sapiens_hsa030202.74384375
12Nucleotide excision repair_Homo sapiens_hsa034202.60347393
13One carbon pool by folate_Homo sapiens_hsa006702.59919331
14Non-homologous end-joining_Homo sapiens_hsa034502.42793309
15Pyrimidine metabolism_Homo sapiens_hsa002402.17801087
16* RNA degradation_Homo sapiens_hsa030182.09376556
17Proteasome_Homo sapiens_hsa030502.01288686
18Fanconi anemia pathway_Homo sapiens_hsa034601.86002778
19p53 signaling pathway_Homo sapiens_hsa041151.84504254
20Ribosome_Homo sapiens_hsa030101.83556681
21Folate biosynthesis_Homo sapiens_hsa007901.60854245
22mRNA surveillance pathway_Homo sapiens_hsa030151.58663442
23Protein export_Homo sapiens_hsa030601.46661530
24Propanoate metabolism_Homo sapiens_hsa006401.32708971
25Selenocompound metabolism_Homo sapiens_hsa004501.32493841
26Purine metabolism_Homo sapiens_hsa002301.29024828
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27874847
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27045844
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.25909806
30Herpes simplex infection_Homo sapiens_hsa051681.21376643
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.21251383
32Thyroid cancer_Homo sapiens_hsa052161.13674709
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10038623
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08128409
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07698387
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.04026695
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03133042
38Epstein-Barr virus infection_Homo sapiens_hsa051691.02625161
39Fatty acid elongation_Homo sapiens_hsa000621.00690135
40Primary immunodeficiency_Homo sapiens_hsa053400.96799709
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92233781
42Viral carcinogenesis_Homo sapiens_hsa052030.90148446
43Antigen processing and presentation_Homo sapiens_hsa046120.89642164
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.86562446
45Pyruvate metabolism_Homo sapiens_hsa006200.82501604
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81942623
47N-Glycan biosynthesis_Homo sapiens_hsa005100.80991807
48Biosynthesis of amino acids_Homo sapiens_hsa012300.79962573
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79811340
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79240222
51Small cell lung cancer_Homo sapiens_hsa052220.71486838
52HTLV-I infection_Homo sapiens_hsa051660.71459330
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70627162
54Oocyte meiosis_Homo sapiens_hsa041140.68762866
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66861561
56Sulfur relay system_Homo sapiens_hsa041220.66600552
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60842223
58Systemic lupus erythematosus_Homo sapiens_hsa053220.58912497
59Lysine degradation_Homo sapiens_hsa003100.58764744
60Steroid biosynthesis_Homo sapiens_hsa001000.57487447
61Peroxisome_Homo sapiens_hsa041460.56715984
62Fatty acid metabolism_Homo sapiens_hsa012120.56138837
63Butanoate metabolism_Homo sapiens_hsa006500.55969890
64Colorectal cancer_Homo sapiens_hsa052100.55820709
65TGF-beta signaling pathway_Homo sapiens_hsa043500.52617778
66MicroRNAs in cancer_Homo sapiens_hsa052060.52048406
67Pentose phosphate pathway_Homo sapiens_hsa000300.50202622
68Notch signaling pathway_Homo sapiens_hsa043300.49693504
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48071822
70Circadian rhythm_Homo sapiens_hsa047100.47366371
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43332903
72Hepatitis B_Homo sapiens_hsa051610.42789697
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41227550
74Vitamin digestion and absorption_Homo sapiens_hsa049770.40255765
75Galactose metabolism_Homo sapiens_hsa000520.39657403
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39270008
77Legionellosis_Homo sapiens_hsa051340.39060282
78Chronic myeloid leukemia_Homo sapiens_hsa052200.38359329
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38167825
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37975702
81Acute myeloid leukemia_Homo sapiens_hsa052210.37618297
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36253886
83Pancreatic cancer_Homo sapiens_hsa052120.34888826
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34555078
85Vitamin B6 metabolism_Homo sapiens_hsa007500.33956433
86Prostate cancer_Homo sapiens_hsa052150.32955886
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.32223715
88Measles_Homo sapiens_hsa051620.30967821
89Glutathione metabolism_Homo sapiens_hsa004800.30941946
90Regulation of autophagy_Homo sapiens_hsa041400.30525083
91mTOR signaling pathway_Homo sapiens_hsa041500.30457149
92Huntingtons disease_Homo sapiens_hsa050160.30235416
93Apoptosis_Homo sapiens_hsa042100.27739141
94Hippo signaling pathway_Homo sapiens_hsa043900.27568328
95beta-Alanine metabolism_Homo sapiens_hsa004100.25689360
96Adherens junction_Homo sapiens_hsa045200.25275424
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23993887
98Fructose and mannose metabolism_Homo sapiens_hsa000510.23851092
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23551056
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23354826
101Shigellosis_Homo sapiens_hsa051310.22367356
102Fatty acid degradation_Homo sapiens_hsa000710.22244948
103Carbon metabolism_Homo sapiens_hsa012000.21958281
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21937282
105Sphingolipid metabolism_Homo sapiens_hsa006000.21725540
106Pathways in cancer_Homo sapiens_hsa052000.21711311
107Hematopoietic cell lineage_Homo sapiens_hsa046400.21229152
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21109263
109Influenza A_Homo sapiens_hsa051640.21040227
110Caffeine metabolism_Homo sapiens_hsa002320.20789333
111Nitrogen metabolism_Homo sapiens_hsa009100.19884868
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.18521449
113FoxO signaling pathway_Homo sapiens_hsa040680.18267338
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16281681
115Alcoholism_Homo sapiens_hsa050340.16054482
116Non-small cell lung cancer_Homo sapiens_hsa052230.15651044
117Prolactin signaling pathway_Homo sapiens_hsa049170.15530681
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.14558626
119Basal cell carcinoma_Homo sapiens_hsa052170.14327026
120Wnt signaling pathway_Homo sapiens_hsa043100.14314409
121Metabolic pathways_Homo sapiens_hsa011000.13999450
122Tryptophan metabolism_Homo sapiens_hsa003800.13385002
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12378527
124Parkinsons disease_Homo sapiens_hsa050120.11800463
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.11626816
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10602813

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