PARP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.36286615
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.36286615
3antigen processing and presentation of endogenous antigen (GO:0019883)5.62612626
4positive regulation of gamma-delta T cell activation (GO:0046645)4.88547351
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.49273797
6negative regulation of cell killing (GO:0031342)4.49273797
7detection of bacterium (GO:0016045)4.34329285
8proline biosynthetic process (GO:0006561)4.33133518
9detection of other organism (GO:0098543)4.29409044
10macrophage activation involved in immune response (GO:0002281)4.06478440
11regulation of gamma-delta T cell differentiation (GO:0045586)4.00095466
12response to peptidoglycan (GO:0032494)3.91768005
13regulation of gamma-delta T cell activation (GO:0046643)3.81389955
14positive regulation of protein homooligomerization (GO:0032464)3.72965461
15embryonic process involved in female pregnancy (GO:0060136)3.70296020
16response to type I interferon (GO:0034340)3.69448966
17leukocyte aggregation (GO:0070486)3.67971211
18neutrophil activation involved in immune response (GO:0002283)3.66414874
19type I interferon signaling pathway (GO:0060337)3.64976310
20cellular response to type I interferon (GO:0071357)3.64976310
21germinal center formation (GO:0002467)3.61653416
22cellular response to zinc ion (GO:0071294)3.59776461
23proline metabolic process (GO:0006560)3.57710623
24regulation of dendritic cell antigen processing and presentation (GO:0002604)3.57483770
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.56282818
26detection of external biotic stimulus (GO:0098581)3.51824283
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.45797888
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.45461620
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.36422534
30regulation of integrin activation (GO:0033623)3.34835103
31response to muramyl dipeptide (GO:0032495)3.31760312
32antigen processing and presentation via MHC class Ib (GO:0002475)3.28263100
33positive thymic T cell selection (GO:0045059)3.22563578
34T cell migration (GO:0072678)3.19978269
35NIK/NF-kappaB signaling (GO:0038061)3.19880905
36negative regulation of T cell mediated immunity (GO:0002710)3.18372830
37negative regulation of leukocyte mediated immunity (GO:0002704)3.16293239
38regulation of T cell tolerance induction (GO:0002664)3.14030369
39defense response to protozoan (GO:0042832)3.10704154
40negative regulation of cytokine production involved in immune response (GO:0002719)3.10509489
41regulation of antigen processing and presentation (GO:0002577)3.09585527
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.09062180
43positive regulation of humoral immune response (GO:0002922)3.08244388
44lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06889051
45regulation of B cell receptor signaling pathway (GO:0050855)3.06349954
46regulation of type I interferon-mediated signaling pathway (GO:0060338)3.06132756
47detection of biotic stimulus (GO:0009595)3.04042045
48positive regulation of type 2 immune response (GO:0002830)3.04005423
49response to interferon-alpha (GO:0035455)3.01768852
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.01451290
51positive regulation of interferon-alpha production (GO:0032727)3.01179750
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.01142076
53response to host immune response (GO:0052572)3.01142076
54negative regulation of interleukin-12 production (GO:0032695)2.96408002
55sulfur amino acid catabolic process (GO:0000098)2.96067156
56negative thymic T cell selection (GO:0045060)2.94701725
57negative T cell selection (GO:0043383)2.94600710
58mannose metabolic process (GO:0006013)2.94088647
59response to protozoan (GO:0001562)2.93512316
60detection of molecule of bacterial origin (GO:0032490)2.92120034
61* negative regulation of viral genome replication (GO:0045071)2.91213060
62regulation of mast cell degranulation (GO:0043304)2.90675413
63regulation of tolerance induction (GO:0002643)2.89862919
64negative regulation of type 2 immune response (GO:0002829)2.88756936
65regulation of type 2 immune response (GO:0002828)2.88478218
66response to host (GO:0075136)2.85908535
67response to host defenses (GO:0052200)2.85908535
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.85908535
69myeloid dendritic cell differentiation (GO:0043011)2.84931947
70cellular response to interferon-gamma (GO:0071346)2.84816423
71regulation of interferon-alpha production (GO:0032647)2.84660984
72regulation of cholesterol homeostasis (GO:2000188)2.84421961
73regulation of T-helper 1 cell differentiation (GO:0045625)2.84304538
74regulation of protein homooligomerization (GO:0032462)2.83606546
75regulation of interleukin-12 biosynthetic process (GO:0045075)2.82921666
76regulation of T-helper 2 cell differentiation (GO:0045628)2.82847699
77immunoglobulin mediated immune response (GO:0016064)2.79637627
78myeloid cell activation involved in immune response (GO:0002275)2.79014883
79negative regulation of fatty acid biosynthetic process (GO:0045717)2.77351168
80transcription from mitochondrial promoter (GO:0006390)2.77196173
81JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.76349712
82regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75506208
83cellular response to interferon-alpha (GO:0035457)2.74474905
84cellular extravasation (GO:0045123)2.74253369
85positive regulation of Cdc42 GTPase activity (GO:0043089)2.69304075
86tolerance induction (GO:0002507)2.68397689
87regulation of leukocyte degranulation (GO:0043300)2.68024671
88myeloid dendritic cell activation (GO:0001773)2.67753809
89respiratory burst (GO:0045730)2.67589008
90response to interferon-gamma (GO:0034341)2.67145491
91cellular response to virus (GO:0098586)2.66707222
92positive regulation of interferon-beta production (GO:0032728)2.66581980
93neutrophil activation (GO:0042119)2.66408607
94regulation of T cell mediated cytotoxicity (GO:0001914)2.66135561
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.65251644
96regulation of cholesterol storage (GO:0010885)2.64570421
97macrophage activation (GO:0042116)2.64398708
98response to interferon-beta (GO:0035456)2.64301089
99lymphocyte chemotaxis (GO:0048247)2.63854537
100positive regulation by symbiont of host defense response (GO:0052509)2.62311865
101modulation by symbiont of host defense response (GO:0052031)2.62311865
102modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62311865
103modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62311865
104positive regulation by organism of defense response of other organism involved in symbiotic interact2.62311865
105modulation by symbiont of host immune response (GO:0052553)2.62311865
106regulation of mast cell activation involved in immune response (GO:0033006)2.60716479
107positive regulation of natural killer cell differentiation (GO:0032825)2.60549780
108regulation of response to interferon-gamma (GO:0060330)2.58877737
109positive regulation of protein oligomerization (GO:0032461)2.57967008
110regulation of B cell differentiation (GO:0045577)2.57871574
111negative regulation of type I interferon production (GO:0032480)2.57624424
112interferon-gamma-mediated signaling pathway (GO:0060333)2.57160962
113embryonic placenta development (GO:0001892)2.54993990
114thymic T cell selection (GO:0045061)2.54791382
115positive regulation of B cell differentiation (GO:0045579)2.48198259
116positive regulation of antigen processing and presentation (GO:0002579)2.46640238
117negative regulation of erythrocyte differentiation (GO:0045647)2.44609188
118low-density lipoprotein particle clearance (GO:0034383)2.44151347
119plasma lipoprotein particle assembly (GO:0034377)2.44003092
120valine metabolic process (GO:0006573)2.41726984
121negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.40819202
122leukocyte cell-cell adhesion (GO:0007159)2.40342641
123regulation of interferon-beta biosynthetic process (GO:0045357)2.40310000
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.39259951
125L-phenylalanine metabolic process (GO:0006558)2.38619728
126erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.38619728
127fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.37685689
128regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.37072600
129oxidative demethylation (GO:0070989)2.35153451
130triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.33692316
131glutamine family amino acid biosynthetic process (GO:0009084)2.33391057
132positive T cell selection (GO:0043368)2.32861825
133B cell mediated immunity (GO:0019724)2.32054601
134phospholipid efflux (GO:0033700)2.31005307
135T cell selection (GO:0045058)2.30643015
136very-low-density lipoprotein particle assembly (GO:0034379)2.29872996
137negative regulation of stress fiber assembly (GO:0051497)2.29756591
138B cell receptor signaling pathway (GO:0050853)2.28812311
139intestinal cholesterol absorption (GO:0030299)2.28422751
140negative regulation of innate immune response (GO:0045824)2.27662398
141regulation of isotype switching to IgG isotypes (GO:0048302)2.26994218
142negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.26852759
143protein carboxylation (GO:0018214)2.26195729
144peptidyl-glutamic acid carboxylation (GO:0017187)2.26195729
145positive regulation of isotype switching (GO:0045830)2.26027434
146cellular response to interferon-beta (GO:0035458)2.25613469
147complement activation, alternative pathway (GO:0006957)2.24574316
148alkaloid metabolic process (GO:0009820)2.24022528
149regulation of podosome assembly (GO:0071801)2.23937115
150mature B cell differentiation (GO:0002335)2.23754442
151cholesterol efflux (GO:0033344)2.23210815
152response to interleukin-15 (GO:0070672)2.22920238
153protein-lipid complex assembly (GO:0065005)2.22763822
154plasma lipoprotein particle clearance (GO:0034381)2.21035252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.65782560
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.40000782
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.16427751
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.97594310
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.87574170
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74969810
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72870639
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.70064237
9VDR_21846776_ChIP-Seq_THP-1_Human2.61404216
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.60645422
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.43823657
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31293590
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.28061434
14MYC_22102868_ChIP-Seq_BL_Human2.24831171
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15817967
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.15253351
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.08718550
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06905909
19MAF_26560356_Chip-Seq_TH1_Human2.06594072
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05824169
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.05510271
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04551026
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97779810
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94217628
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92655893
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90707386
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.90705055
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87914158
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83583041
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80281439
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.76620584
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.76509129
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74652445
34UTX_26944678_Chip-Seq_JUKART_Human1.69461508
35TCF7_22412390_ChIP-Seq_EML_Mouse1.68153793
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65680988
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.64399222
38* VDR_24763502_ChIP-Seq_THP-1_Human1.64114119
39MYB_26560356_Chip-Seq_TH1_Human1.64001531
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62616993
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62512340
42* LXR_22292898_ChIP-Seq_THP-1_Human1.62291598
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60529379
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.59400931
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.59146808
46* MYB_26560356_Chip-Seq_TH2_Human1.54410682
47SCL_19346495_ChIP-Seq_HPC-7_Human1.52437277
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47785417
49* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46671759
50* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46159263
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42764609
52SPI1_23547873_ChIP-Seq_NB4_Human1.41552490
53* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40672694
54MAF_26560356_Chip-Seq_TH2_Human1.39478121
55* KDM2B_26808549_Chip-Seq_DND41_Human1.38189173
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38086692
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37687480
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36746658
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36237881
60RUNX_20019798_ChIP-Seq_JUKART_Human1.33999795
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32976384
62* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31844301
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31624131
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30770686
65* KDM2B_26808549_Chip-Seq_JURKAT_Human1.29035724
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28993041
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27962663
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26596422
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.25402476
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25334873
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25099942
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24896274
73* P68_20966046_ChIP-Seq_HELA_Human1.23439822
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23311542
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.23017165
76RACK7_27058665_Chip-Seq_MCF-7_Human1.21176905
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20281489
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.19968599
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18605183
80GATA1_22025678_ChIP-Seq_K562_Human1.18551257
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16069949
82VDR_24787735_ChIP-Seq_THP-1_Human1.15133503
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15080493
84GATA1_19941826_ChIP-Seq_K562_Human1.14579192
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13551034
86SMC4_20622854_ChIP-Seq_HELA_Human1.12510186
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12173042
88* KDM2B_26808549_Chip-Seq_K562_Human1.11992080
89PU_27001747_Chip-Seq_BMDM_Mouse1.09206491
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09105814
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.08334880
92GATA3_27048872_Chip-Seq_THYMUS_Human1.06868530
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.06638374
94* SPI1_23127762_ChIP-Seq_K562_Human1.06559531
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05641283
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04690048
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03894305
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03571334
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00804938
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00156096
101CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99922014
102NCOR1_26117541_ChIP-Seq_K562_Human0.99506720
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99184825
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98820196
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97502789
106ZNF263_19887448_ChIP-Seq_K562_Human0.97448548
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96153834
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95532842
109BCOR_27268052_Chip-Seq_Bcells_Human0.95309733
110CTCF_26484167_Chip-Seq_Bcells_Mouse0.94791662
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94189264
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94168321
113CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93561002
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93478849
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92763974
116BCL6_27268052_Chip-Seq_Bcells_Human0.91993648
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89486067
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89229855
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88726597
120RXRA_24833708_ChIP-Seq_LIVER_Mouse0.88296335
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86637965
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85640755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system2.98330392
2MP0001835_abnormal_antigen_presentation2.85452694
3MP0009278_abnormal_bone_marrow2.46358917
4MP0003436_decreased_susceptibility_to2.43626481
5MP0005360_urolithiasis2.42764876
6MP0009785_altered_susceptibility_to2.38258740
7MP0002139_abnormal_hepatobiliary_system2.34911959
8MP0005365_abnormal_bile_salt2.33055712
9MP0006082_CNS_inflammation2.30130078
10MP0002166_altered_tumor_susceptibility2.28457780
11MP0009840_abnormal_foam_cell2.22211740
12MP0001790_abnormal_immune_system2.17279085
13MP0005387_immune_system_phenotype2.17279085
14MP0003191_abnormal_cellular_cholesterol2.17212665
15MP0005085_abnormal_gallbladder_physiolo2.14294049
16MP0001800_abnormal_humoral_immune2.07958401
17MP0005025_abnormal_response_to2.05772779
18MP0001545_abnormal_hematopoietic_system2.02742868
19MP0005397_hematopoietic_system_phenotyp2.02742868
20MP0003763_abnormal_thymus_physiology2.00098619
21MP0005451_abnormal_body_composition1.99270026
22MP0005058_abnormal_lysosome_morphology1.97205690
23MP0005671_abnormal_response_to1.96520640
24MP0005464_abnormal_platelet_physiology1.96031327
25MP0003724_increased_susceptibility_to1.96003579
26MP0002405_respiratory_system_inflammati1.86573286
27MP0005000_abnormal_immune_tolerance1.86206104
28MP0002723_abnormal_immune_serum1.80366948
29MP0002452_abnormal_antigen_presenting1.79298058
30MP0004947_skin_inflammation1.76782336
31MP0003303_peritoneal_inflammation1.76131936
32MP0010155_abnormal_intestine_physiology1.75889558
33MP0002419_abnormal_innate_immunity1.74029129
34MP0002006_tumorigenesis1.71456286
35MP0008260_abnormal_autophagy1.64983251
36MP0001819_abnormal_immune_cell1.63560393
37MP0002420_abnormal_adaptive_immunity1.62909119
38MP0003300_gastrointestinal_ulcer1.61463796
39MP0002148_abnormal_hypersensitivity_rea1.60473651
40MP0003172_abnormal_lysosome_physiology1.59912058
41MP0004510_myositis1.57187104
42MP0002398_abnormal_bone_marrow1.56865249
43MP0002138_abnormal_hepatobiliary_system1.53952626
44MP0002396_abnormal_hematopoietic_system1.51924744
45MP0001873_stomach_inflammation1.50965862
46MP0003453_abnormal_keratinocyte_physiol1.50147124
47MP0003183_abnormal_peptide_metabolism1.50047608
48MP0000689_abnormal_spleen_morphology1.49912125
49MP0001845_abnormal_inflammatory_respons1.48007430
50MP0000609_abnormal_liver_physiology1.44840208
51MP0009333_abnormal_splenocyte_physiolog1.44710238
52MP0000716_abnormal_immune_system1.44625997
53MP0010352_gastrointestinal_tract_polyps1.43558985
54MP0001853_heart_inflammation1.43243633
55MP0008469_abnormal_protein_level1.39138157
56MP0002998_abnormal_bone_remodeling1.38143238
57MP0002722_abnormal_immune_system1.36385516
58MP0008875_abnormal_xenobiotic_pharmacok1.34450442
59MP0003656_abnormal_erythrocyte_physiolo1.32777169
60MP0008057_abnormal_DNA_replication1.32189277
61MP0010329_abnormal_lipoprotein_level1.28919885
62MP0003252_abnormal_bile_duct1.27828140
63MP0002429_abnormal_blood_cell1.25744696
64MP0005174_abnormal_tail_pigmentation1.23023327
65MP0003705_abnormal_hypodermis_morpholog1.18724588
66MP0005083_abnormal_biliary_tract1.17737028
67MP0005166_decreased_susceptibility_to1.16563536
68MP0009764_decreased_sensitivity_to1.14767005
69MP0001533_abnormal_skeleton_physiology1.14189047
70MP0004381_abnormal_hair_follicle1.13283621
71MP0003866_abnormal_defecation1.12166396
72MP0005319_abnormal_enzyme/_coenzyme1.09979871
73MP0003566_abnormal_cell_adhesion1.09510757
74MP0003690_abnormal_glial_cell1.08139403
75MP0002009_preneoplasia1.08053065
76MP0002254_reproductive_system_inflammat1.08011263
77MP0001851_eye_inflammation1.07848436
78MP0005023_abnormal_wound_healing1.07268052
79MP0000604_amyloidosis1.05326204
80MP0001666_abnormal_nutrient_absorption1.04929783
81MP0003091_abnormal_cell_migration1.04164626
82MP0003045_fibrosis1.04150695
83MP0000858_altered_metastatic_potential1.02975019
84MP0000703_abnormal_thymus_morphology1.00851803
85MP0003448_altered_tumor_morphology1.00005874
86MP0000490_abnormal_crypts_of0.98976046
87MP0002132_abnormal_respiratory_system0.98914995
88MP0004883_abnormal_blood_vessel0.97842628
89MP0005075_abnormal_melanosome_morpholog0.97127016
90MP0000598_abnormal_liver_morphology0.96975314
91MP0005076_abnormal_cell_differentiation0.96705657
92MP0000343_altered_response_to0.96060367
93MP0003828_pulmonary_edema0.94425761
94MP0009763_increased_sensitivity_to0.93512693
95MP0000371_diluted_coat_color0.93511206
96MP0001663_abnormal_digestive_system0.93429878
97MP0005390_skeleton_phenotype0.92883910
98MP0002933_joint_inflammation0.90712741
99MP0010307_abnormal_tumor_latency0.87435485
100MP0004019_abnormal_vitamin_homeostasis0.87280623
101MP0005332_abnormal_amino_acid0.86927834
102MP0004808_abnormal_hematopoietic_stem0.86736522
103MP0003806_abnormal_nucleotide_metabolis0.86361255
104MP0002019_abnormal_tumor_incidence0.85965378
105MP0005164_abnormal_response_to0.85796646
106MP0002118_abnormal_lipid_homeostasis0.85323921
107MP0001849_ear_inflammation0.84500256
108MP0009643_abnormal_urine_homeostasis0.84381489
109MP0003075_altered_response_to0.84251040
110MP0002060_abnormal_skin_morphology0.80307908
111MP0003186_abnormal_redox_activity0.80024192
112MP0009115_abnormal_fat_cell0.79147572
113MP0000249_abnormal_blood_vessel0.78818801
114MP0002877_abnormal_melanocyte_morpholog0.78752799
115MP0000465_gastrointestinal_hemorrhage0.76433792
116MP0008004_abnormal_stomach_pH0.75963678
117MP0005310_abnormal_salivary_gland0.74925184
118MP0002796_impaired_skin_barrier0.74899247
119MP0005584_abnormal_enzyme/coenzyme_acti0.74591307
120MP0008874_decreased_physiological_sensi0.74539029
121MP0004858_abnormal_nervous_system0.74421116
122MP0003279_aneurysm0.73185159
123MP0003795_abnormal_bone_structure0.71689232
124MP0005666_abnormal_adipose_tissue0.68422411
125MP0005381_digestive/alimentary_phenotyp0.61490643
126MP0002277_abnormal_respiratory_mucosa0.59736774
127MP0001958_emphysema0.57994520

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)4.60912467
2Retrobulbar optic neuritis (HP:0100654)3.94972085
3Optic neuritis (HP:0100653)3.94972085
4Increased IgM level (HP:0003496)3.93540649
5Nasal polyposis (HP:0100582)3.80339274
6Autoimmune thrombocytopenia (HP:0001973)3.72628939
7Chronic otitis media (HP:0000389)3.70780538
8Abnormality of the nasal mucosa (HP:0000433)3.68516789
9Eczematoid dermatitis (HP:0000976)3.62531313
10Myocardial infarction (HP:0001658)3.36622238
11Elevated erythrocyte sedimentation rate (HP:0003565)3.35855693
12Recurrent fungal infections (HP:0002841)3.23486831
13Gingivitis (HP:0000230)3.14070534
14Chronic obstructive pulmonary disease (HP:0006510)3.13974149
15Obstructive lung disease (HP:0006536)3.13974149
16Stomatitis (HP:0010280)3.10934541
17Recurrent abscess formation (HP:0002722)3.05213005
18Colitis (HP:0002583)3.03824770
19Mucopolysacchariduria (HP:0008155)3.00015839
20Urinary glycosaminoglycan excretion (HP:0003541)3.00015839
21Recurrent bacterial skin infections (HP:0005406)2.93182752
22Myositis (HP:0100614)2.91524366
23Keratoconjunctivitis sicca (HP:0001097)2.91354477
24Recurrent viral infections (HP:0004429)2.90648907
25Recurrent gram-negative bacterial infections (HP:0005420)2.88415560
26Polycythemia (HP:0001901)2.87109315
27Abnormality of T cell number (HP:0011839)2.85988456
28Malnutrition (HP:0004395)2.82992477
29Pulmonary infiltrates (HP:0002113)2.81664902
30Encephalitis (HP:0002383)2.81556429
31T lymphocytopenia (HP:0005403)2.81496509
32Dysostosis multiplex (HP:0000943)2.81399045
33Loss of speech (HP:0002371)2.79345274
34Gastrointestinal stroma tumor (HP:0100723)2.78819621
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.77340331
36Abnormality of polysaccharide metabolism (HP:0011012)2.77340331
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.77340331
38Abnormality of T cells (HP:0002843)2.77140606
39Xanthomatosis (HP:0000991)2.74615536
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.73860113
41Abnormality of liposaccharide metabolism (HP:0010968)2.72883623
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.72883623
43Abnormality of glycolipid metabolism (HP:0010969)2.72883623
44Abnormality of T cell physiology (HP:0011840)2.70912525
45Albinism (HP:0001022)2.70172467
46Recurrent bronchitis (HP:0002837)2.68999936
47Hemoptysis (HP:0002105)2.68835725
48Poikiloderma (HP:0001029)2.67938052
49Deep venous thrombosis (HP:0002625)2.66438279
50Joint hemorrhage (HP:0005261)2.64756261
51Alopecia of scalp (HP:0002293)2.63921226
52Inflammation of the large intestine (HP:0002037)2.63768182
53Gingival bleeding (HP:0000225)2.62116358
54Keratoconjunctivitis (HP:0001096)2.60822578
55Hypochromic anemia (HP:0001931)2.60473341
56Agammaglobulinemia (HP:0004432)2.59556127
57Gastrointestinal inflammation (HP:0004386)2.59192843
58Epistaxis (HP:0000421)2.57445318
59Vacuolated lymphocytes (HP:0001922)2.55762541
60Abnormal platelet volume (HP:0011876)2.53494643
61Systemic lupus erythematosus (HP:0002725)2.53074879
62IgA deficiency (HP:0002720)2.49657573
63Hypergammaglobulinemia (HP:0010702)2.47495067
64Intrahepatic cholestasis (HP:0001406)2.46452932
65Hypobetalipoproteinemia (HP:0003563)2.44943194
66Emphysema (HP:0002097)2.44738945
67Complement deficiency (HP:0004431)2.42708704
68Prolonged bleeding time (HP:0003010)2.42630052
69Purpura (HP:0000979)2.42504527
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40980605
71Increased cerebral lipofuscin (HP:0011813)2.40709817
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.40413063
73Increased mean platelet volume (HP:0011877)2.39749968
74Ulnar bowing (HP:0003031)2.39415514
75Orchitis (HP:0100796)2.36270314
76Menorrhagia (HP:0000132)2.36060474
77Chest pain (HP:0100749)2.35880370
78Spontaneous hematomas (HP:0007420)2.35456936
79Hypochromic microcytic anemia (HP:0004840)2.34201143
80Abnormality of macrophages (HP:0004311)2.32105311
81Osteomyelitis (HP:0002754)2.28583156
82Interstitial pulmonary disease (HP:0006530)2.28272413
83Thrombocytosis (HP:0001894)2.26722203
84Recurrent skin infections (HP:0001581)2.26350032
85Glomerulonephritis (HP:0000099)2.25548953
86Pulmonary embolism (HP:0002204)2.23434626
87Abnormality of glutamine family amino acid metabolism (HP:0010902)2.22678672
88Vasculitis (HP:0002633)2.19934025
89Abnormality of complement system (HP:0005339)2.18980917
90Lymphopenia (HP:0001888)2.17940623
91Impaired platelet aggregation (HP:0003540)2.17900911
92Abnormal platelet function (HP:0011869)2.17900911
93Nephritis (HP:0000123)2.17576992
94Periodontitis (HP:0000704)2.17345843
95Hemorrhage of the eye (HP:0011885)2.16680334
96Increased IgE level (HP:0003212)2.15511291
97Abnormality of the common coagulation pathway (HP:0010990)2.14944856
98Restrictive lung disease (HP:0002091)2.13974004
99Amyloidosis (HP:0011034)2.13852400
100Mediastinal lymphadenopathy (HP:0100721)2.13212232
101Premature loss of primary teeth (HP:0006323)2.11528855
102Asymmetric septal hypertrophy (HP:0001670)2.11093238
103Anorexia (HP:0002039)2.09818913
104Granulocytopenia (HP:0001913)2.08149062
105Abnormal hemoglobin (HP:0011902)2.07389189
106Prolonged partial thromboplastin time (HP:0003645)2.06960101
107IgM deficiency (HP:0002850)2.06605375
108Abnormality of cells of the lymphoid lineage (HP:0012140)2.05610510
109Cheilitis (HP:0100825)2.03902285
110Increased serum ferritin (HP:0003281)2.03826196
111Combined immunodeficiency (HP:0005387)2.03799732
112Esophageal varix (HP:0002040)2.03577371
113Abnormality of the pleura (HP:0002103)2.02781203
114Increased neuronal autofluorescent lipopigment (HP:0002074)2.02571860
115Joint swelling (HP:0001386)2.00793792
116Cellulitis (HP:0100658)1.99962289
117Thin bony cortex (HP:0002753)1.99542690
118Recurrent cutaneous fungal infections (HP:0011370)1.99376736
119Chronic mucocutaneous candidiasis (HP:0002728)1.99376736
120Hyperlipoproteinemia (HP:0010980)1.99183673
121Sepsis (HP:0100806)1.98488479
122Cerebral aneurysm (HP:0004944)1.96959877
123Obstructive sleep apnea (HP:0002870)1.96893998
124Hepatosplenomegaly (HP:0001433)1.96630032
125Abnormality of iron homeostasis (HP:0011031)1.96127879
126Leukocytosis (HP:0001974)1.95752308
127Polygenic inheritance (HP:0010982)1.95555931
128Gangrene (HP:0100758)1.95513243
129Skin ulcer (HP:0200042)1.94057240
130Hematochezia (HP:0002573)1.93572121
131Arterial thrombosis (HP:0004420)1.92072163
132Lower limb hyperreflexia (HP:0002395)1.91070226
133Microcytic anemia (HP:0001935)1.91031719
134IgG deficiency (HP:0004315)1.89681840
135Urticaria (HP:0001025)1.87893918
136Meningitis (HP:0001287)1.87541883
137Panhypogammaglobulinemia (HP:0003139)1.87442638
138Autoimmune hemolytic anemia (HP:0001890)1.87234832
139Severe combined immunodeficiency (HP:0004430)1.86693980
140Petechiae (HP:0000967)1.86382383
141Arthralgia (HP:0002829)1.86117087
142Growth hormone excess (HP:0000845)1.85279046
143Hypertriglyceridemia (HP:0002155)1.85192972
144Gastrointestinal infarctions (HP:0005244)1.84541931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.25482747
2MAP4K13.22717817
3TYK22.92605324
4PRPF4B2.86942052
5ERN12.75150734
6CSK2.55068055
7FGFR42.53436564
8TBK12.36302327
9JAK32.35232937
10MAPK152.28291387
11ICK2.26792985
12MAP3K142.18209730
13IKBKE2.17118512
14TNK22.08457919
15JAK12.01337254
16MAP3K111.98597707
17MAP3K61.97543995
18TRIB31.96036001
19MAP3K101.91342216
20MATK1.90921517
21PIM21.87789636
22KIT1.83068424
23BLK1.71240225
24DDR21.66237973
25ZAP701.63409337
26IKBKB1.61567171
27SMG11.54150903
28TAOK11.51577390
29FES1.51321495
30PIM11.51000414
31TAOK31.50974034
32BMX1.48950086
33FGR1.48679930
34TXK1.47962469
35TGFBR21.45316550
36FLT31.42680016
37SIK11.31090911
38CDC42BPA1.31078915
39STK101.30209220
40SIK31.29908789
41PKN21.28658533
42MAPK111.27479418
43EPHB11.26352730
44BTK1.24320786
45RIPK11.24126695
46PRKD21.23143796
47TRPM71.22105100
48ITK1.19183480
49TAOK21.18820155
50CDK61.18641214
51NME21.18400139
52DYRK1B1.15045953
53PDGFRA1.14222040
54FGFR31.12818700
55LCK1.12623925
56JAK21.12502379
57MAP3K11.11182129
58IRAK31.07805556
59CHUK1.06811836
60GRK61.06598819
61MARK21.06329124
62MAP2K31.06136305
63IRAK41.05781423
64EEF2K1.01819136
65MAP3K131.00629310
66CSF1R0.98880994
67BCKDK0.97560687
68KDR0.95512381
69SYK0.93438117
70RPS6KA60.90342241
71PINK10.87571297
72LYN0.87514353
73HIPK20.87157333
74RPS6KC10.86747323
75RPS6KL10.86747323
76TTN0.85837943
77HCK0.85704235
78LRRK20.85269065
79TESK20.84940043
80PTK60.78018299
81DAPK10.75411752
82TYRO30.75205865
83GSK3A0.74581450
84MAPK70.74430836
85PDPK10.72081145
86PDK10.70778633
87TEC0.69946027
88RPS6KA40.68605458
89EPHA30.67545507
90GRK70.66545237
91MAP2K60.66335466
92MAP3K30.65494393
93YES10.65232894
94CDK70.63724192
95MAPK120.63474957
96CDK120.63193702
97IRAK10.60039260
98NLK0.59249504
99MAPK40.57920039
100EGFR0.56929727
101CDK40.54426360
102NEK90.53351058
103PRKAA20.52903197
104RPS6KA20.51740931
105TESK10.51451311
106KSR20.51033285
107IRAK20.49923212
108TGFBR10.49866409
109RPS6KA10.49469654
110FYN0.48080226
111MST1R0.47308029
112PDGFRB0.45518069
113SIK20.45511057
114CAMKK10.45205479
115CAMK1D0.44631604
116STK40.44615499
117RPS6KB20.43981341
118MTOR0.43363559
119MAPKAPK20.41826668
120MAP3K70.40326045
121ABL10.40020512
122MAPK30.38374886
123BMPR20.38274135
124MAPKAPK30.37904979
125PTK20.36747600
126RET0.36269630
127MARK30.34797876
128MAP2K20.33915586
129PRKCD0.33427061
130MOS0.32928523
131PRKCQ0.31688568

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.82960707
2Staphylococcus aureus infection_Homo sapiens_hsa051502.58952362
3Autoimmune thyroid disease_Homo sapiens_hsa053202.48442800
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.28123595
5Caffeine metabolism_Homo sapiens_hsa002322.22225576
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08412720
7Measles_Homo sapiens_hsa051621.96991616
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.94194629
9Asthma_Homo sapiens_hsa053101.89697584
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89256508
11Leishmaniasis_Homo sapiens_hsa051401.88876228
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85516548
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84951202
14Type I diabetes mellitus_Homo sapiens_hsa049401.81337612
15Fatty acid biosynthesis_Homo sapiens_hsa000611.80996490
16Arginine biosynthesis_Homo sapiens_hsa002201.76123162
17Complement and coagulation cascades_Homo sapiens_hsa046101.74755378
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.54297484
19B cell receptor signaling pathway_Homo sapiens_hsa046621.54003610
20Antigen processing and presentation_Homo sapiens_hsa046121.53438323
21Osteoclast differentiation_Homo sapiens_hsa043801.49865305
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49440437
23Herpes simplex infection_Homo sapiens_hsa051681.47181640
24Tryptophan metabolism_Homo sapiens_hsa003801.41365393
25Legionellosis_Homo sapiens_hsa051341.41360947
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39066844
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36155342
28ABC transporters_Homo sapiens_hsa020101.34840529
29Sulfur relay system_Homo sapiens_hsa041221.32423047
30Fatty acid degradation_Homo sapiens_hsa000711.28602239
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.23458742
32Influenza A_Homo sapiens_hsa051641.20695497
33African trypanosomiasis_Homo sapiens_hsa051431.19932359
34Acute myeloid leukemia_Homo sapiens_hsa052211.18376123
35Rheumatoid arthritis_Homo sapiens_hsa053231.17962081
36Fatty acid metabolism_Homo sapiens_hsa012121.16919040
37Folate biosynthesis_Homo sapiens_hsa007901.14360216
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13899305
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.13184202
40TNF signaling pathway_Homo sapiens_hsa046681.09806718
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09783040
42PPAR signaling pathway_Homo sapiens_hsa033201.06572353
43Toxoplasmosis_Homo sapiens_hsa051451.06229175
44Lysine degradation_Homo sapiens_hsa003101.05761763
45Base excision repair_Homo sapiens_hsa034101.04227178
46Shigellosis_Homo sapiens_hsa051311.03940277
47Allograft rejection_Homo sapiens_hsa053301.02628712
48Selenocompound metabolism_Homo sapiens_hsa004501.02470698
49Phagosome_Homo sapiens_hsa041451.00839804
50Malaria_Homo sapiens_hsa051440.99470729
51Hematopoietic cell lineage_Homo sapiens_hsa046400.98577556
52Apoptosis_Homo sapiens_hsa042100.97264949
53T cell receptor signaling pathway_Homo sapiens_hsa046600.93807916
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92311926
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.92130574
56Graft-versus-host disease_Homo sapiens_hsa053320.91960676
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91537193
58Pertussis_Homo sapiens_hsa051330.91475360
59Hepatitis C_Homo sapiens_hsa051600.91345212
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91259831
61Notch signaling pathway_Homo sapiens_hsa043300.90210671
62Peroxisome_Homo sapiens_hsa041460.89815253
63Viral myocarditis_Homo sapiens_hsa054160.88505187
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88319383
65Hepatitis B_Homo sapiens_hsa051610.87977874
66Other glycan degradation_Homo sapiens_hsa005110.87321539
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83070185
68Nitrogen metabolism_Homo sapiens_hsa009100.82785729
69Non-small cell lung cancer_Homo sapiens_hsa052230.82191077
70Histidine metabolism_Homo sapiens_hsa003400.81783596
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.81761442
72Tuberculosis_Homo sapiens_hsa051520.81624613
73Arginine and proline metabolism_Homo sapiens_hsa003300.79540493
74Lysosome_Homo sapiens_hsa041420.79497457
75Starch and sucrose metabolism_Homo sapiens_hsa005000.79168812
76Chronic myeloid leukemia_Homo sapiens_hsa052200.78722570
77Platelet activation_Homo sapiens_hsa046110.77083477
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76182264
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73747001
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73668237
81Small cell lung cancer_Homo sapiens_hsa052220.72398556
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71288821
83Epstein-Barr virus infection_Homo sapiens_hsa051690.71182021
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.70160634
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.69947675
86Insulin resistance_Homo sapiens_hsa049310.69654305
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69316995
88Biosynthesis of amino acids_Homo sapiens_hsa012300.68472808
89Chemokine signaling pathway_Homo sapiens_hsa040620.68102327
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66605061
91Prion diseases_Homo sapiens_hsa050200.66579728
92beta-Alanine metabolism_Homo sapiens_hsa004100.66301309
93Amoebiasis_Homo sapiens_hsa051460.65371991
94Viral carcinogenesis_Homo sapiens_hsa052030.65331129
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64299403
96Fat digestion and absorption_Homo sapiens_hsa049750.63428897
97HTLV-I infection_Homo sapiens_hsa051660.63189586
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62624919
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.62300591
100Chemical carcinogenesis_Homo sapiens_hsa052040.61925084
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61459954
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60925588
103p53 signaling pathway_Homo sapiens_hsa041150.60387857
104mTOR signaling pathway_Homo sapiens_hsa041500.58394047
105Prolactin signaling pathway_Homo sapiens_hsa049170.58285692
106Bladder cancer_Homo sapiens_hsa052190.57590588
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56301296
108Endocytosis_Homo sapiens_hsa041440.55863947
109Mismatch repair_Homo sapiens_hsa034300.55483144
110Fructose and mannose metabolism_Homo sapiens_hsa000510.54100303
111GnRH signaling pathway_Homo sapiens_hsa049120.53495509
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52984959
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.52198353
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51920282
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51332836
116Pancreatic cancer_Homo sapiens_hsa052120.51211373
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50978933
118Salmonella infection_Homo sapiens_hsa051320.50817994
119Galactose metabolism_Homo sapiens_hsa000520.50405161
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49462106
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.49342772
122Renal cell carcinoma_Homo sapiens_hsa052110.49302339
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.47965625
124VEGF signaling pathway_Homo sapiens_hsa043700.47351176
125One carbon pool by folate_Homo sapiens_hsa006700.46925991
126Pentose phosphate pathway_Homo sapiens_hsa000300.46381618
127Choline metabolism in cancer_Homo sapiens_hsa052310.46333446
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.44436769
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43398716
130FoxO signaling pathway_Homo sapiens_hsa040680.37745274
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37416222
132Systemic lupus erythematosus_Homo sapiens_hsa053220.36787151
133Insulin signaling pathway_Homo sapiens_hsa049100.36347258
134Endometrial cancer_Homo sapiens_hsa052130.35573027
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35279167
136HIF-1 signaling pathway_Homo sapiens_hsa040660.34013325
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33375829
138Type II diabetes mellitus_Homo sapiens_hsa049300.32927385
139MAPK signaling pathway_Homo sapiens_hsa040100.31578769
140Inositol phosphate metabolism_Homo sapiens_hsa005620.30802053
141Dorso-ventral axis formation_Homo sapiens_hsa043200.26187299

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