PARP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.98924287
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.98924287
3antigen processing and presentation of endogenous antigen (GO:0019883)5.66803661
4type I interferon signaling pathway (GO:0060337)5.49606454
5cellular response to type I interferon (GO:0071357)5.49606454
6response to type I interferon (GO:0034340)5.45747168
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.09733054
8positive regulation of gamma-delta T cell activation (GO:0046645)4.72917327
9positive regulation of interferon-alpha production (GO:0032727)4.50274680
10response to interferon-alpha (GO:0035455)4.48581984
11positive regulation by symbiont of host defense response (GO:0052509)4.44442401
12modulation by symbiont of host defense response (GO:0052031)4.44442401
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.44442401
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.44442401
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.44442401
16modulation by symbiont of host immune response (GO:0052553)4.44442401
17regulation of interferon-alpha production (GO:0032647)4.20678336
18T cell migration (GO:0072678)4.19689933
19response to host immune response (GO:0052572)4.08673904
20response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.08673904
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08376055
22negative regulation of cell killing (GO:0031342)4.08376055
23interferon-gamma-mediated signaling pathway (GO:0060333)4.00646695
24negative regulation of viral genome replication (GO:0045071)4.00276590
25behavioral response to nicotine (GO:0035095)3.98780518
26positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.95318339
27cellular response to interferon-beta (GO:0035458)3.90068203
28establishment of protein localization to Golgi (GO:0072600)3.88351293
29sperm motility (GO:0030317)3.87506514
30centriole replication (GO:0007099)3.87176628
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.77643351
32epithelial cilium movement (GO:0003351)3.77336413
33response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.68644492
34response to host (GO:0075136)3.68644492
35response to host defenses (GO:0052200)3.68644492
36nonmotile primary cilium assembly (GO:0035058)3.65994292
37regulation of type I interferon-mediated signaling pathway (GO:0060338)3.64630896
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.64234081
39negative regulation of translation, ncRNA-mediated (GO:0040033)3.64234081
40regulation of translation, ncRNA-mediated (GO:0045974)3.64234081
41regulation of cilium movement (GO:0003352)3.63913530
42neural tube formation (GO:0001841)3.62183718
43defense response to protozoan (GO:0042832)3.58214686
44regulation of RIG-I signaling pathway (GO:0039535)3.58143649
45cellular ketone body metabolic process (GO:0046950)3.57834949
46regulation of B cell receptor signaling pathway (GO:0050855)3.57371732
47regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.51864053
48regulation of interferon-beta biosynthetic process (GO:0045357)3.51731483
49regulation of sarcomere organization (GO:0060297)3.49542500
50protein targeting to Golgi (GO:0000042)3.49421428
51detection of light stimulus involved in sensory perception (GO:0050962)3.44400264
52detection of light stimulus involved in visual perception (GO:0050908)3.44400264
53protein polyglutamylation (GO:0018095)3.44263242
54negative T cell selection (GO:0043383)3.44246529
55negative thymic T cell selection (GO:0045060)3.42407049
56acrosome reaction (GO:0007340)3.41723371
57indolalkylamine metabolic process (GO:0006586)3.40473689
58cellular response to exogenous dsRNA (GO:0071360)3.37697261
59response to pheromone (GO:0019236)3.36292120
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33129253
61microtubule depolymerization (GO:0007019)3.31833565
62cellular response to interferon-gamma (GO:0071346)3.31415490
63regulation of alpha-beta T cell proliferation (GO:0046640)3.31261681
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31255497
65immunoglobulin mediated immune response (GO:0016064)3.28661199
66cilium or flagellum-dependent cell motility (GO:0001539)3.28625149
67cellular response to interferon-alpha (GO:0035457)3.27271679
68tryptophan catabolic process (GO:0006569)3.27160134
69indole-containing compound catabolic process (GO:0042436)3.27160134
70indolalkylamine catabolic process (GO:0046218)3.27160134
71response to interferon-beta (GO:0035456)3.25783982
72positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.22471101
73cilium movement (GO:0003341)3.19746187
74pyrimidine nucleobase catabolic process (GO:0006208)3.17911219
75ketone body metabolic process (GO:1902224)3.17749124
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16365397
77protein localization to cilium (GO:0061512)3.16258452
78positive regulation of antigen processing and presentation (GO:0002579)3.15864861
79retrograde transport, vesicle recycling within Golgi (GO:0000301)3.10485979
80regulation of T-helper 1 cell differentiation (GO:0045625)3.07500683
81NIK/NF-kappaB signaling (GO:0038061)3.06741147
82protein localization to Golgi apparatus (GO:0034067)3.05336876
83kynurenine metabolic process (GO:0070189)3.05178666
84B cell receptor signaling pathway (GO:0050853)3.04619172
85natural killer cell mediated cytotoxicity (GO:0042267)3.04023540
86natural killer cell mediated immunity (GO:0002228)3.04023540
87regulation of gamma-delta T cell activation (GO:0046643)3.03735603
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02959363
89multicellular organism reproduction (GO:0032504)3.02732973
90positive regulation of type 2 immune response (GO:0002830)2.99275582
91DNA deamination (GO:0045006)2.98834939
92response to protozoan (GO:0001562)2.97543210
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.96622390
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95733708
95cilium organization (GO:0044782)2.95083399
96monoubiquitinated protein deubiquitination (GO:0035520)2.91580935
97cilium assembly (GO:0042384)2.91425454
98response to interleukin-15 (GO:0070672)2.91226062
99cilium morphogenesis (GO:0060271)2.91092874
100positive T cell selection (GO:0043368)2.90033876
101defense response to virus (GO:0051607)2.89987793
102fucose catabolic process (GO:0019317)2.87840961
103L-fucose metabolic process (GO:0042354)2.87840961
104L-fucose catabolic process (GO:0042355)2.87840961
105T cell selection (GO:0045058)2.87468505
106positive regulation of interleukin-12 production (GO:0032735)2.86563614
107tryptophan metabolic process (GO:0006568)2.85808172
108positive regulation of natural killer cell differentiation (GO:0032825)2.84700144
109positive regulation of alpha-beta T cell proliferation (GO:0046641)2.84381978
110activated T cell proliferation (GO:0050798)2.84134074
111gamma-aminobutyric acid transport (GO:0015812)2.83545540
112somite development (GO:0061053)2.83358441
113single strand break repair (GO:0000012)2.82533582
114regulation of gamma-delta T cell differentiation (GO:0045586)2.82287915
115lymphocyte chemotaxis (GO:0048247)2.81399494
116regulation of female gonad development (GO:2000194)2.80946391
117mast cell activation (GO:0045576)2.79652658
118cellular response to zinc ion (GO:0071294)2.79429944
119amine catabolic process (GO:0009310)2.78292375
120cellular biogenic amine catabolic process (GO:0042402)2.78292375
121antigen processing and presentation via MHC class Ib (GO:0002475)2.77937171
122positive regulation of chemokine biosynthetic process (GO:0045080)2.76970500
123response to interferon-gamma (GO:0034341)2.76680647
124regulation of telomere maintenance (GO:0032204)2.76500510
125cellular response to virus (GO:0098586)2.75140925
126regulation of dendritic cell antigen processing and presentation (GO:0002604)2.75093930
127response to peptidoglycan (GO:0032494)2.74891945
128axoneme assembly (GO:0035082)2.73996043
129regulation of interferon-gamma biosynthetic process (GO:0045072)2.73605526
130cell wall macromolecule metabolic process (GO:0044036)2.73327063
131reflex (GO:0060004)2.73192707
132positive regulation of interferon-beta production (GO:0032728)2.73181177
133interferon-gamma production (GO:0032609)2.73140633
134cellular response to interleukin-15 (GO:0071350)2.71580508
135DNA double-strand break processing (GO:0000729)2.70973103
136regulation of isotype switching to IgG isotypes (GO:0048302)2.70800451
137regulation of collateral sprouting (GO:0048670)2.70325611
138negative regulation of interleukin-17 production (GO:0032700)2.69900576
139cAMP catabolic process (GO:0006198)2.69802607
140positive regulation of interleukin-2 production (GO:0032743)2.69710000
141regulation of antigen processing and presentation (GO:0002577)2.69659219
142microtubule polymerization or depolymerization (GO:0031109)2.69055654
143macrophage activation involved in immune response (GO:0002281)2.68369176
144positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68332203
145spermatid development (GO:0007286)2.68312144
146positive regulation of T cell cytokine production (GO:0002726)2.68230710
147neutrophil activation involved in immune response (GO:0002283)2.67844119
148myeloid dendritic cell activation (GO:0001773)2.67485503
149intraciliary transport (GO:0042073)2.67203663
150positive regulation of defense response to virus by host (GO:0002230)2.67097190
151protein K63-linked deubiquitination (GO:0070536)2.66500276
152T-helper 1 type immune response (GO:0042088)2.66115757
153negative regulation of telomere maintenance (GO:0032205)2.66015397
154hindbrain development (GO:0030902)2.65205584
155B cell mediated immunity (GO:0019724)2.64398870
156sequestering of actin monomers (GO:0042989)2.63969718
157regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.63296511
158myeloid cell activation involved in immune response (GO:0002275)2.63218711
159forebrain neuron differentiation (GO:0021879)2.62975656
160natural killer cell activation (GO:0030101)2.62763423
161positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.62443532
162regulation of defense response to virus by virus (GO:0050690)2.62384904
163regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62050623
164piRNA metabolic process (GO:0034587)2.61354698
165positive regulation of mRNA catabolic process (GO:0061014)2.60664855
166regulation of microtubule-based movement (GO:0060632)2.60306233
167centriole assembly (GO:0098534)2.59720194
168positive regulation of interleukin-1 beta secretion (GO:0050718)2.59375718
169regulation of viral genome replication (GO:0045069)2.59163559
170lymphocyte costimulation (GO:0031294)2.58564531
171axonemal dynein complex assembly (GO:0070286)2.58096450
172regulation of MHC class II biosynthetic process (GO:0045346)2.56159996
173photoreceptor cell maintenance (GO:0045494)2.54806476
174seminiferous tubule development (GO:0072520)2.52536792
175positive regulation of T cell differentiation in thymus (GO:0033089)2.50785559
176histone H3-K9 methylation (GO:0051567)2.50309329
177spinal cord motor neuron differentiation (GO:0021522)2.49220139
178nucleobase catabolic process (GO:0046113)2.47609265
179limb development (GO:0060173)2.46299045
180appendage development (GO:0048736)2.46299045
181negative regulation of systemic arterial blood pressure (GO:0003085)2.45885109
182positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.44117663
183regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.44117663
184indole-containing compound metabolic process (GO:0042430)2.40382073
185glycosphingolipid biosynthetic process (GO:0006688)2.39461253
186cyclic nucleotide catabolic process (GO:0009214)2.39373956
187recombinational repair (GO:0000725)2.36709762
188regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.35815638
189positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.35815638
190cerebral cortex radially oriented cell migration (GO:0021799)2.35151993
191neuronal action potential (GO:0019228)2.35080126
192photoreceptor cell development (GO:0042461)2.34538606
193DNA demethylation (GO:0080111)2.34421533
194kidney morphogenesis (GO:0060993)2.34420711
195platelet dense granule organization (GO:0060155)2.32897190
196dentate gyrus development (GO:0021542)2.32831382
197brain morphogenesis (GO:0048854)2.32121844
198rRNA catabolic process (GO:0016075)2.31634434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.90644869
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.96716677
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.86564763
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.84287796
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.67713177
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.70350178
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.29369357
8ZNF274_21170338_ChIP-Seq_K562_Hela3.17141096
9* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.17045188
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06639675
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.05689957
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.02020814
13VDR_22108803_ChIP-Seq_LS180_Human2.82067909
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74513702
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.58410549
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53378018
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46941594
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46795482
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42293011
20E2F7_22180533_ChIP-Seq_HELA_Human2.39475209
21IGF1R_20145208_ChIP-Seq_DFB_Human2.36937815
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34749882
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.33069417
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.30297005
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.28374124
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.18909062
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.13327155
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.08194574
29FUS_26573619_Chip-Seq_HEK293_Human2.04760190
30MYB_26560356_Chip-Seq_TH2_Human2.03811916
31SCL_19346495_ChIP-Seq_HPC-7_Human2.02153786
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98879616
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97727092
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87737387
35ER_23166858_ChIP-Seq_MCF-7_Human1.86372685
36RUNX_20019798_ChIP-Seq_JUKART_Human1.84421299
37* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.77084668
38* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77084668
39MYC_22102868_ChIP-Seq_BL_Human1.76772647
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76760137
41* SPI1_23547873_ChIP-Seq_NB4_Human1.76340763
42AR_21572438_ChIP-Seq_LNCaP_Human1.75874838
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75265141
44EWS_26573619_Chip-Seq_HEK293_Human1.75014791
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71782229
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69931291
47CBP_20019798_ChIP-Seq_JUKART_Human1.68370924
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68370924
49MAF_26560356_Chip-Seq_TH1_Human1.68032550
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67158478
51VDR_21846776_ChIP-Seq_THP-1_Human1.65665045
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.64271147
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61923922
54STAT3_23295773_ChIP-Seq_U87_Human1.61826369
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61340279
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59945453
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58247948
58MYB_26560356_Chip-Seq_TH1_Human1.56879356
59VDR_24763502_ChIP-Seq_THP-1_Human1.55734082
60BCAT_22108803_ChIP-Seq_LS180_Human1.54587569
61UTX_26944678_Chip-Seq_JUKART_Human1.54217264
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.53173763
63AR_25329375_ChIP-Seq_VCAP_Human1.53164774
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52959734
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52119365
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48634781
67* TCF4_23295773_ChIP-Seq_U87_Human1.47060862
68* PRDM14_20953172_ChIP-Seq_ESCs_Human1.44957040
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.44917894
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44432715
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44245457
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43091828
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41972382
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.40406993
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39628138
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39508103
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39254721
78RUNX2_22187159_ChIP-Seq_PCA_Human1.39119175
79SPI1_23127762_ChIP-Seq_K562_Human1.38786067
80RNF2_27304074_Chip-Seq_NSC_Mouse1.38106335
81IRF1_19129219_ChIP-ChIP_H3396_Human1.36567798
82NANOG_19829295_ChIP-Seq_ESCs_Human1.33665452
83SOX2_19829295_ChIP-Seq_ESCs_Human1.33665452
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33102212
85* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32416494
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32223801
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.31347472
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30970556
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30605469
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.30431377
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.30228532
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30075393
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28846129
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.27547244
95* GATA3_27048872_Chip-Seq_THYMUS_Human1.27448367
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27089694
97TCF4_22108803_ChIP-Seq_LS180_Human1.26880655
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25608868
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.24314257
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23732146
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.23389283
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.21976859
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19335794
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18914233
105* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17982238
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15221309
107DROSHA_22980978_ChIP-Seq_HELA_Human1.14663715
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14192003
109CIITA_25753668_ChIP-Seq_RAJI_Human1.14132780
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13363304
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12826952
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11649959
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11235255
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09838860
115TP63_19390658_ChIP-ChIP_HaCaT_Human1.08919052
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08422449
117EZH2_22144423_ChIP-Seq_EOC_Human1.07492415
118PU_27001747_Chip-Seq_BMDM_Mouse1.07482438
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06191035
120HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05629024
121ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05306591
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05213208
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05032866
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.03999866
125BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03867358
126P53_22387025_ChIP-Seq_ESCs_Mouse1.03579117
127FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03332468
128FOXA1_25329375_ChIP-Seq_VCAP_Human1.03332468
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02816600
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01622561
131TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01551408
132EZH2_27304074_Chip-Seq_ESCs_Mouse1.01119830
133KDM2B_26808549_Chip-Seq_REH_Human1.00820651
134GATA1_22025678_ChIP-Seq_K562_Human1.00458840
135* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99875150
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.99605784
137* GATA3_26560356_Chip-Seq_TH2_Human0.99156690
138CDX2_22108803_ChIP-Seq_LS180_Human0.99043703
139OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97218813
140* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96664563
141VDR_24787735_ChIP-Seq_THP-1_Human0.96521491
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.96235092
143GATA3_21878914_ChIP-Seq_MCF-7_Human0.96127052
144* MAF_26560356_Chip-Seq_TH2_Human0.95652608
145* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95310747
146GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95308946
147HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94935203
148* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94630292
149STAT3_18555785_Chip-Seq_ESCs_Mouse0.93701280
150GBX2_23144817_ChIP-Seq_PC3_Human0.93441937
151P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92967825
152SMRT_27268052_Chip-Seq_Bcells_Human0.92910002
153TCF7_22412390_ChIP-Seq_EML_Mouse0.89307428
154* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88584160
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87893914
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86526683
157GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82582780
158MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82531246
159* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81967966
160CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81350375
161CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80894669
162KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77816922
163EGR1_19032775_ChIP-ChIP_M12_Human0.77812585
164ELF1_17652178_ChIP-ChIP_JURKAT_Human0.77249548
165ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74572907
166* GATA1_19941827_ChIP-Seq_MEL_Mouse0.74540673
167TAF15_26573619_Chip-Seq_HEK293_Human0.72497888
168PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72215180
169THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70872748
170ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69071247
171KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.67564956
172PU.1_20513432_ChIP-Seq_Bcells_Mouse0.65957781
173PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.65344868
174CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.64903959
175KDM2B_26808549_Chip-Seq_DND41_Human0.64641965
176* P300_19829295_ChIP-Seq_ESCs_Human0.64618408
177PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63851076
178RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.62402386
179KDM2B_26808549_Chip-Seq_SUP-B15_Human0.60492291
180TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.59499184
181CTCF_26484167_Chip-Seq_Bcells_Mouse0.59073807
182REST_21632747_ChIP-Seq_MESCs_Mouse0.57896539
183CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.57862591
184CBX2_27304074_Chip-Seq_ESCs_Mouse0.56662743
185TP53_22573176_ChIP-Seq_HFKS_Human0.56611582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.20736045
2MP0000569_abnormal_digit_pigmentation3.76517083
3MP0009785_altered_susceptibility_to3.70360791
4MP0005671_abnormal_response_to3.36966735
5MP0000685_abnormal_immune_system3.31561126
6MP0005387_immune_system_phenotype2.92142695
7MP0001790_abnormal_immune_system2.92142695
8MP0001800_abnormal_humoral_immune2.88403492
9MP0002148_abnormal_hypersensitivity_rea2.76961150
10MP0004510_myositis2.76566001
11MP0005025_abnormal_response_to2.76536622
12MP0005000_abnormal_immune_tolerance2.70737722
13MP0002452_abnormal_antigen_presenting2.66939539
14MP0002723_abnormal_immune_serum2.57625917
15MP0001819_abnormal_immune_cell2.45224410
16MP0002420_abnormal_adaptive_immunity2.40566704
17MP0003763_abnormal_thymus_physiology2.30497710
18MP0002419_abnormal_innate_immunity2.28130513
19MP0002398_abnormal_bone_marrow2.25887599
20MP0006082_CNS_inflammation2.24466199
21MP0003195_calcinosis2.21347764
22MP0003303_peritoneal_inflammation2.21071927
23MP0003436_decreased_susceptibility_to2.15620007
24MP0004142_abnormal_muscle_tone2.13334358
25MP0005551_abnormal_eye_electrophysiolog2.10721489
26MP0003172_abnormal_lysosome_physiology2.02670270
27MP0000716_abnormal_immune_system2.01990594
28MP0001501_abnormal_sleep_pattern1.96357821
29MP0003724_increased_susceptibility_to1.94940284
30MP0003136_yellow_coat_color1.92873278
31MP0002166_altered_tumor_susceptibility1.87186113
32MP0008057_abnormal_DNA_replication1.84533612
33MP0002006_tumorigenesis1.81390160
34MP0003880_abnormal_central_pattern1.75175152
35MP0001486_abnormal_startle_reflex1.71562225
36MP0005174_abnormal_tail_pigmentation1.70106134
37MP0004885_abnormal_endolymph1.69315184
38MP0005377_hearing/vestibular/ear_phenot1.69229017
39MP0003878_abnormal_ear_physiology1.69229017
40MP0003183_abnormal_peptide_metabolism1.68888647
41MP0000015_abnormal_ear_pigmentation1.68145041
42MP0003787_abnormal_imprinting1.68122567
43MP0004742_abnormal_vestibular_system1.67424300
44MP0005464_abnormal_platelet_physiology1.66104280
45MP0003646_muscle_fatigue1.65962219
46MP0001485_abnormal_pinna_reflex1.63963160
47MP0002429_abnormal_blood_cell1.63838430
48MP0009745_abnormal_behavioral_response1.61435973
49MP0005423_abnormal_somatic_nervous1.58772716
50MP0005253_abnormal_eye_physiology1.58265053
51MP0000689_abnormal_spleen_morphology1.57287486
52MP0002138_abnormal_hepatobiliary_system1.50748925
53MP0002722_abnormal_immune_system1.50616465
54MP0003698_abnormal_male_reproductive1.50148619
55MP0005084_abnormal_gallbladder_morpholo1.48589112
56MP0000703_abnormal_thymus_morphology1.46526639
57MP0004808_abnormal_hematopoietic_stem1.43361715
58MP0001845_abnormal_inflammatory_respons1.43187426
59MP0008872_abnormal_physiological_respon1.42829157
60MP0002272_abnormal_nervous_system1.42660783
61MP0002405_respiratory_system_inflammati1.41650144
62MP0009764_decreased_sensitivity_to1.39845019
63MP0002653_abnormal_ependyma_morphology1.39813941
64MP0002557_abnormal_social/conspecific_i1.34592180
65MP0010155_abnormal_intestine_physiology1.33662666
66MP0002572_abnormal_emotion/affect_behav1.33526608
67MP0001905_abnormal_dopamine_level1.33339722
68MP0004947_skin_inflammation1.33222763
69MP0009278_abnormal_bone_marrow1.32981188
70MP0002938_white_spotting1.32318628
71MP0001440_abnormal_grooming_behavior1.30610632
72MP0002067_abnormal_sensory_capabilities1.29969513
73MP0002396_abnormal_hematopoietic_system1.29359832
74MP0003448_altered_tumor_morphology1.29020764
75MP0001348_abnormal_lacrimal_gland1.28929958
76MP0001929_abnormal_gametogenesis1.27816478
77MP0001545_abnormal_hematopoietic_system1.26436121
78MP0005397_hematopoietic_system_phenotyp1.26436121
79MP0008995_early_reproductive_senescence1.26208563
80MP0002102_abnormal_ear_morphology1.24697669
81MP0002733_abnormal_thermal_nociception1.24257963
82MP0009333_abnormal_splenocyte_physiolog1.23999130
83MP0002277_abnormal_respiratory_mucosa1.23779907
84MP0003283_abnormal_digestive_organ1.21421782
85MP0006072_abnormal_retinal_apoptosis1.21129536
86MP0002837_dystrophic_cardiac_calcinosis1.20848546
87MP0001970_abnormal_pain_threshold1.17792775
88MP0005310_abnormal_salivary_gland1.17497261
89MP0002638_abnormal_pupillary_reflex1.16641001
90MP0002163_abnormal_gland_morphology1.15967765
91MP0000631_abnormal_neuroendocrine_gland1.13742247
92MP0001986_abnormal_taste_sensitivity1.11831093
93MP0004858_abnormal_nervous_system1.11003746
94MP0000858_altered_metastatic_potential1.10818341
95MP0001533_abnormal_skeleton_physiology1.09097157
96MP0004859_abnormal_synaptic_plasticity1.08793832
97MP0001529_abnormal_vocalization1.07709114
98MP0000026_abnormal_inner_ear1.06750057
99MP0002928_abnormal_bile_duct1.06459785
100MP0005646_abnormal_pituitary_gland1.05931678
101MP0002822_catalepsy1.05681091
102MP0008469_abnormal_protein_level1.05451197
103MP0000681_abnormal_thyroid_gland1.03308726
104MP0000371_diluted_coat_color1.01903683
105MP0005076_abnormal_cell_differentiation1.01413086
106MP0002095_abnormal_skin_pigmentation1.00310836
107MP0001963_abnormal_hearing_physiology1.00025415
108MP0003121_genomic_imprinting0.99506131
109MP0000465_gastrointestinal_hemorrhage0.98372099
110MP0002064_seizures0.97689418
111MP0005195_abnormal_posterior_eye0.96076082
112MP0004133_heterotaxia0.95136125
113MP0004043_abnormal_pH_regulation0.94659609
114MP0009046_muscle_twitch0.93039522
115MP0001873_stomach_inflammation0.92438427
116MP0003718_maternal_effect0.91516610
117MP0001324_abnormal_eye_pigmentation0.91495882
118MP0002752_abnormal_somatic_nervous0.90772682
119MP0004811_abnormal_neuron_physiology0.90448703
120MP0002734_abnormal_mechanical_nocicepti0.89366854
121MP0008789_abnormal_olfactory_epithelium0.88716908
122MP0002210_abnormal_sex_determination0.87878302
123MP0003943_abnormal_hepatobiliary_system0.86675054
124MP0002229_neurodegeneration0.85424943
125MP0003011_delayed_dark_adaptation0.84572986
126MP0000049_abnormal_middle_ear0.84432881
127MP0002998_abnormal_bone_remodeling0.84354102
128MP0008058_abnormal_DNA_repair0.83507553
129MP0004924_abnormal_behavior0.83181785
130MP0005386_behavior/neurological_phenoty0.83181785
131MP0006276_abnormal_autonomic_nervous0.82348346
132MP0003890_abnormal_embryonic-extraembry0.80932874
133MP0001853_heart_inflammation0.80687837
134MP0005645_abnormal_hypothalamus_physiol0.79650154
135MP0004782_abnormal_surfactant_physiolog0.79361436
136MP0002234_abnormal_pharynx_morphology0.78404375
137MP0002751_abnormal_autonomic_nervous0.77408809
138MP0000653_abnormal_sex_gland0.77212631
139MP0003091_abnormal_cell_migration0.77146562
140MP0005391_vision/eye_phenotype0.75909589
141MP0002735_abnormal_chemical_nociception0.74533130
142MP0010386_abnormal_urinary_bladder0.74528704
143MP0004147_increased_porphyrin_level0.74190812
144MP0000778_abnormal_nervous_system0.73794338
145MP0002063_abnormal_learning/memory/cond0.73074702
146MP0001145_abnormal_male_reproductive0.72515233
147MP0001188_hyperpigmentation0.71902276
148MP0002882_abnormal_neuron_morphology0.71564327
149MP0005167_abnormal_blood-brain_barrier0.71212595
150MP0006292_abnormal_olfactory_placode0.68530254
151MP0002933_joint_inflammation0.66372242
152MP0005058_abnormal_lysosome_morphology0.66325981
153MP0003300_gastrointestinal_ulcer0.66078684
154MP0003866_abnormal_defecation0.66001474
155MP0002736_abnormal_nociception_after0.62754197
156MP0001663_abnormal_digestive_system0.61982496
157MP0008877_abnormal_DNA_methylation0.60640189
158MP0000490_abnormal_crypts_of0.59198374
159MP0003122_maternal_imprinting0.57960557
160MP0002019_abnormal_tumor_incidence0.56809872
161MP0003635_abnormal_synaptic_transmissio0.55756430
162MP0001984_abnormal_olfaction0.55436204
163MP0003077_abnormal_cell_cycle0.53096007
164MP0008007_abnormal_cellular_replicative0.52939105
165MP0001968_abnormal_touch/_nociception0.51953331
166MP0005410_abnormal_fertilization0.51857408
167MP0000313_abnormal_cell_death0.51408867
168MP0000372_irregular_coat_pigmentation0.50197071
169MP0005075_abnormal_melanosome_morpholog0.49507337
170MP0008569_lethality_at_weaning0.49322853

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)4.45813664
2Recurrent bronchitis (HP:0002837)4.30728599
3Elevated erythrocyte sedimentation rate (HP:0003565)4.18183183
4Pancreatic cysts (HP:0001737)3.93299004
5Recurrent viral infections (HP:0004429)3.87668787
6True hermaphroditism (HP:0010459)3.84069789
7Recurrent abscess formation (HP:0002722)3.74195593
8Molar tooth sign on MRI (HP:0002419)3.72023641
9Abnormality of midbrain morphology (HP:0002418)3.72023641
10Chronic sinusitis (HP:0011109)3.65280529
11Pancreatic fibrosis (HP:0100732)3.60050704
12Congenital stationary night blindness (HP:0007642)3.59266480
13Nephronophthisis (HP:0000090)3.54810741
14Nasal polyposis (HP:0100582)3.52735409
15Recurrent bacterial skin infections (HP:0005406)3.51443085
16Recurrent fungal infections (HP:0002841)3.47077294
17Increased IgM level (HP:0003496)3.43928120
18Mediastinal lymphadenopathy (HP:0100721)3.43389743
19Medial flaring of the eyebrow (HP:0010747)3.41008633
20Vasculitis (HP:0002633)3.26927070
21Recurrent cutaneous fungal infections (HP:0011370)3.23205761
22Chronic mucocutaneous candidiasis (HP:0002728)3.23205761
23Myositis (HP:0100614)3.19537287
24Autoimmune thrombocytopenia (HP:0001973)3.16661104
25Cortical dysplasia (HP:0002539)3.16534451
26Gait imbalance (HP:0002141)3.16040719
27Genetic anticipation (HP:0003743)3.14008863
28Eczematoid dermatitis (HP:0000976)3.12887330
29Abnormal rod and cone electroretinograms (HP:0008323)3.10947409
30Nephrogenic diabetes insipidus (HP:0009806)3.07716151
31Congenital primary aphakia (HP:0007707)3.07528486
32Hyperventilation (HP:0002883)3.07144541
33Chronic hepatic failure (HP:0100626)3.07058887
34Agammaglobulinemia (HP:0004432)3.05377598
35Abnormality of the renal medulla (HP:0100957)3.05105124
36Periodontitis (HP:0000704)3.02814058
37Thyroiditis (HP:0100646)2.95962686
38Attenuation of retinal blood vessels (HP:0007843)2.92158476
39Abnormality of T cell number (HP:0011839)2.91260455
40Abnormality of the renal cortex (HP:0011035)2.86899458
41Progressive cerebellar ataxia (HP:0002073)2.86360923
42IgM deficiency (HP:0002850)2.85817925
43Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.84713444
44Panhypogammaglobulinemia (HP:0003139)2.83460117
45Abnormality of the nasal mucosa (HP:0000433)2.81775865
46Abnormality of T cells (HP:0002843)2.77203424
47T lymphocytopenia (HP:0005403)2.75016240
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.74811647
49IgG deficiency (HP:0004315)2.74415069
50Recurrent skin infections (HP:0001581)2.72819209
51Genital tract atresia (HP:0001827)2.72730354
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.72634759
53Retinal dysplasia (HP:0007973)2.70581634
54Stomatitis (HP:0010280)2.69618433
55Severe visual impairment (HP:0001141)2.69277114
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.69098508
57Absent/shortened dynein arms (HP:0200106)2.69098508
58Recurrent gram-negative bacterial infections (HP:0005420)2.68753893
59Vaginal atresia (HP:0000148)2.68162095
60Abnormal hair whorl (HP:0010721)2.67042590
61Retrobulbar optic neuritis (HP:0100654)2.66463201
62Optic neuritis (HP:0100653)2.66463201
63Bronchitis (HP:0012387)2.66244763
64Large eyes (HP:0001090)2.64888973
65Recurrent sinusitis (HP:0011108)2.64397029
66Lymphopenia (HP:0001888)2.63420075
67Decreased central vision (HP:0007663)2.59380334
68Meningitis (HP:0001287)2.57701967
69Abnormality of macular pigmentation (HP:0008002)2.57429267
70Severe combined immunodeficiency (HP:0004430)2.57381034
71Gingivitis (HP:0000230)2.57074893
72Abolished electroretinogram (ERG) (HP:0000550)2.56561726
73Hypergammaglobulinemia (HP:0010702)2.54366660
74Poor coordination (HP:0002370)2.53605918
75Cystic liver disease (HP:0006706)2.52179992
76Sclerocornea (HP:0000647)2.50187307
77Gastrointestinal inflammation (HP:0004386)2.49081727
78Orchitis (HP:0100796)2.46204019
79Basal ganglia calcification (HP:0002135)2.44681531
80Inflammation of the large intestine (HP:0002037)2.39711807
81Absent speech (HP:0001344)2.38256204
82Bony spicule pigmentary retinopathy (HP:0007737)2.35886794
83Volvulus (HP:0002580)2.35354976
84Disinhibition (HP:0000734)2.35015969
85Abnormality of T cell physiology (HP:0011840)2.33570855
86Hypoplastic ischia (HP:0003175)2.33261143
87Chronic obstructive pulmonary disease (HP:0006510)2.32699386
88Obstructive lung disease (HP:0006536)2.32699386
89Inappropriate behavior (HP:0000719)2.31610804
90Stomach cancer (HP:0012126)2.30212149
91Recurrent pneumonia (HP:0006532)2.30202429
92Porencephaly (HP:0002132)2.30049408
93Tubulointerstitial nephritis (HP:0001970)2.27672483
94Abnormality of the fingertips (HP:0001211)2.25217860
95Type II lissencephaly (HP:0007260)2.24702410
96Chronic diarrhea (HP:0002028)2.23748730
97Recurrent lower respiratory tract infections (HP:0002783)2.22768585
98Gaze-evoked nystagmus (HP:0000640)2.22411542
99Abnormal respiratory epithelium morphology (HP:0012253)2.22221263
100Abnormal respiratory motile cilium morphology (HP:0005938)2.22221263
101Abnormal ciliary motility (HP:0012262)2.21232228
102Abnormality of eosinophils (HP:0001879)2.20302243
103Chest pain (HP:0100749)2.19040649
104Anencephaly (HP:0002323)2.18408031
105Optic nerve hypoplasia (HP:0000609)2.17996808
106Congenital hepatic fibrosis (HP:0002612)2.17802340
107Combined immunodeficiency (HP:0005387)2.17457621
108Renal cortical cysts (HP:0000803)2.14380083
109Aplasia/Hypoplasia of the tongue (HP:0010295)2.13553344
110Cleft eyelid (HP:0000625)2.10704742
111Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09719681
112B lymphocytopenia (HP:0010976)2.09473444
113Abnormality of B cell number (HP:0010975)2.09473444
114Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07214208
115Thrombocytosis (HP:0001894)2.07201548
116Leukocytosis (HP:0001974)2.06725323
117Polydipsia (HP:0001959)2.05526862
118Abnormal drinking behavior (HP:0030082)2.05526862
119Tubular atrophy (HP:0000092)2.04838554
120Cellulitis (HP:0100658)2.03822432
121Autoimmune hemolytic anemia (HP:0001890)2.03782382
122Gastrointestinal stroma tumor (HP:0100723)2.03007238
123Febrile seizures (HP:0002373)2.02808458
124Male pseudohermaphroditism (HP:0000037)2.02570925
125Intestinal atresia (HP:0011100)2.02259497
126Abnormality of the ischium (HP:0003174)2.02185304
127Petechiae (HP:0000967)2.01820253
128Diminished motivation (HP:0000745)2.00714633
129Eosinophilia (HP:0001880)1.99904119
130Hemoptysis (HP:0002105)1.99636358
131Absent frontal sinuses (HP:0002688)1.98548194
132Polyphagia (HP:0002591)1.98353028
133Postaxial foot polydactyly (HP:0001830)1.98291313
134Pulmonary infiltrates (HP:0002113)1.96426414
135Increased cerebral lipofuscin (HP:0011813)1.95333314
136Emphysema (HP:0002097)1.92984790
137Abnormality of the endocardium (HP:0004306)1.91364268
138Pendular nystagmus (HP:0012043)1.90923470
139Abnormal respiratory motile cilium physiology (HP:0012261)1.90096887
140Joint swelling (HP:0001386)1.89848149
141Abnormality of macrophages (HP:0004311)1.89792985
142Broad-based gait (HP:0002136)1.89121995
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.88344627
144Inability to walk (HP:0002540)1.87911932
145Gingival bleeding (HP:0000225)1.87783669
146Postaxial hand polydactyly (HP:0001162)1.87508767
147Arterial thrombosis (HP:0004420)1.87178828
148Increased neuronal autofluorescent lipopigment (HP:0002074)1.86319077
149Progressive inability to walk (HP:0002505)1.84635509
150Tubulointerstitial abnormality (HP:0001969)1.84611445
151IgA deficiency (HP:0002720)1.84231643
152Hypoplasia of the thymus (HP:0000778)1.84226769
153Lissencephaly (HP:0001339)1.84154048
154Protruding tongue (HP:0010808)1.83531461
155Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82693260
156Hypoplasia of the pons (HP:0012110)1.82332900
157Interstitial pulmonary disease (HP:0006530)1.80261521
158Hypoplasia of the fovea (HP:0007750)1.79926200
159Aplasia/Hypoplasia of the fovea (HP:0008060)1.79926200
160Lymphoma (HP:0002665)1.79314508
161Prolonged bleeding time (HP:0003010)1.79233190
162Aplasia/Hypoplasia of the lens (HP:0008063)1.78229353
163Apathy (HP:0000741)1.78184246
164Thyroid-stimulating hormone excess (HP:0002925)1.78149420
165Abnormality of the pons (HP:0007361)1.77593633
166Focal motor seizures (HP:0011153)1.77486999
167Poor head control (HP:0002421)1.77157083
168Congenital, generalized hypertrichosis (HP:0004540)1.75899659
169Astigmatism (HP:0000483)1.75776689
170Gastrointestinal infarctions (HP:0005244)1.74612098
171Osteomyelitis (HP:0002754)1.73997063
172Atonic seizures (HP:0010819)1.73678092
173Narrow forehead (HP:0000341)1.73126064
174Loss of speech (HP:0002371)1.72675304
175Specific learning disability (HP:0001328)1.72472750
176Syringomyelia (HP:0003396)1.72076831
177Spinal cord lesions (HP:0100561)1.72076831
178Dyskinesia (HP:0100660)1.70685764
179Polyuria (HP:0000103)1.70540709
180Widely spaced teeth (HP:0000687)1.70519325
181Drooling (HP:0002307)1.70345098
182Anterior segment dysgenesis (HP:0007700)1.69733555
183Increased corneal curvature (HP:0100692)1.67304173
184Keratoconus (HP:0000563)1.67304173
185Abnormality of the labia minora (HP:0012880)1.67252979
186Retinitis pigmentosa (HP:0000510)1.67199235
187Growth hormone deficiency (HP:0000824)1.66400421
188Oligodactyly (hands) (HP:0001180)1.64238071
189Clumsiness (HP:0002312)1.63355893
190Cupped ear (HP:0000378)1.63275704
191Macular degeneration (HP:0000608)1.62386911
192Broad foot (HP:0001769)1.61824637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.33016879
2SIK33.64024630
3PBK3.62665343
4TYK23.61018031
5MAP4K13.42836097
6TXK3.09413030
7KIT3.03380315
8BMPR1B2.89000759
9MAP3K142.81696372
10MARK12.67239412
11JAK32.66239704
12IKBKE2.65522042
13MAP4K22.63581414
14TBK12.54755064
15INSRR2.45928969
16BLK2.38909586
17ERBB32.17196215
18JAK12.15336991
19SYK2.14478192
20SIK22.13926704
21FGFR42.07459285
22NUAK12.06784157
23TAOK31.87389284
24WNK31.79829909
25ZAP701.74377687
26GRK11.71322635
27PNCK1.70677759
28FGFR31.61480015
29MAP3K101.61065811
30CSF1R1.60618542
31PLK41.60439094
32TNIK1.51093741
33ZAK1.48949010
34CAMKK21.48398505
35MAP3K131.45466641
36MKNK21.44245084
37HCK1.43718343
38PINK11.38790227
39IRAK41.38630603
40FES1.35731544
41RIPK41.35330879
42CASK1.30880126
43EPHB21.27019033
44DYRK21.23834816
45MAPK131.23033052
46LMTK21.22524796
47KSR11.21960563
48IKBKB1.20009023
49TRIM281.18777790
50BCKDK1.15186011
51NTRK21.14284274
52CHUK1.13226198
53BTK1.12183195
54IRAK11.11745529
55OXSR11.09813221
56LCK1.09672954
57RPS6KA41.08595058
58MAP2K71.07639170
59MAPK151.06837014
60WNK41.06235055
61LYN1.06190666
62EIF2AK21.05105985
63STK391.04030970
64NTRK31.03551998
65NLK1.03322924
66TNK21.02039925
67CAMK1G1.00297671
68MAP3K120.98878102
69PAK30.98833612
70STK38L0.95627348
71PRKCE0.93798091
72TGFBR10.92927854
73BRSK20.87702512
74VRK10.87180040
75ATR0.84787144
76DAPK10.84027093
77EEF2K0.83791551
78YES10.82302714
79TESK10.78418297
80CCNB10.73028117
81MINK10.72879120
82EPHA30.72390744
83CAMK1D0.72196259
84PRKCG0.70677005
85CDK30.70303758
86SGK20.69679051
87ADRBK10.67866946
88BMPR20.67646154
89PASK0.67222629
90TEC0.64577408
91JAK20.60334983
92PLK20.60007861
93MAP3K50.59906686
94DAPK20.59505922
95STK40.58589277
96ITK0.55848126
97EPHA40.55585759
98WNK10.55467215
99MKNK10.55433950
100PKN10.54594628
101DYRK1B0.53457580
102CDK190.53321781
103MAP3K40.52978656
104PIM20.52953370
105ACVR1B0.52396527
106GRK60.51020274
107BCR0.48863006
108FYN0.48381987
109TYRO30.48184224
110CAMKK10.46291648
111CAMK10.45540504
112PIK3CA0.45008967
113MAP3K90.44776383
114STK110.44696548
115ADRBK20.44557791
116CAMK40.44120676
117PIK3CG0.43683742
118PRKCD0.43420017
119SGK2230.43113389
120SGK4940.43113389
121TLK10.42048142
122GRK70.41750785
123TIE10.41655472
124IRAK30.41357162
125MATK0.41268365
126CLK10.40628048
127CSNK1G10.39725012
128SGK30.39546137
129CDK40.39473251
130SRPK10.39442518
131PRKCH0.37193006
132PRKAA20.36899096
133IGF1R0.36762940
134EGFR0.36615623
135CSK0.36123362
136NEK20.35364586
137AKT30.35040222
138STK240.34652453
139BRD40.33404976
140PRKACA0.33316708
141SRC0.32013331
142PIM10.31978292
143PRKG20.29888580
144MARK30.28744006
145SCYL20.28518555
146DYRK30.28227700
147CDK50.27942322
148PKN20.26956991
149CSNK1A1L0.25314738
150PRKCQ0.24278439
151CSNK1G20.23433970
152CSNK1G30.23333800
153ERBB20.23230967
154RET0.22936768
155CDK180.20982988
156CDK60.20888974

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.25932014
2Phototransduction_Homo sapiens_hsa047443.03666361
3Primary immunodeficiency_Homo sapiens_hsa053402.94077201
4Measles_Homo sapiens_hsa051622.51731404
5Allograft rejection_Homo sapiens_hsa053302.46127605
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.41461683
7Butanoate metabolism_Homo sapiens_hsa006502.40409209
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.32373645
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30739714
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.27492904
11Autoimmune thyroid disease_Homo sapiens_hsa053202.24223150
12Leishmaniasis_Homo sapiens_hsa051402.22920592
13Graft-versus-host disease_Homo sapiens_hsa053322.16664588
14Influenza A_Homo sapiens_hsa051642.11036577
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.10638605
16Herpes simplex infection_Homo sapiens_hsa051682.05922265
17Selenocompound metabolism_Homo sapiens_hsa004502.03042287
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99420148
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.96093239
20Linoleic acid metabolism_Homo sapiens_hsa005911.94016070
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85720382
22Type I diabetes mellitus_Homo sapiens_hsa049401.79449284
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77602863
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74619922
25Legionellosis_Homo sapiens_hsa051341.72043816
26B cell receptor signaling pathway_Homo sapiens_hsa046621.69445628
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68729540
28Osteoclast differentiation_Homo sapiens_hsa043801.64031912
29Antigen processing and presentation_Homo sapiens_hsa046121.62012680
30Fanconi anemia pathway_Homo sapiens_hsa034601.60003121
31Taste transduction_Homo sapiens_hsa047421.58259314
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57575616
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54823404
34T cell receptor signaling pathway_Homo sapiens_hsa046601.52407106
35Nitrogen metabolism_Homo sapiens_hsa009101.49912273
36Homologous recombination_Homo sapiens_hsa034401.49837634
37Ether lipid metabolism_Homo sapiens_hsa005651.48571646
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.47054030
39Chemokine signaling pathway_Homo sapiens_hsa040621.46289213
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44756812
41GABAergic synapse_Homo sapiens_hsa047271.42537158
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40739570
43Tuberculosis_Homo sapiens_hsa051521.39601667
44Hematopoietic cell lineage_Homo sapiens_hsa046401.39423929
45TNF signaling pathway_Homo sapiens_hsa046681.38780285
46Tryptophan metabolism_Homo sapiens_hsa003801.37720002
47Hepatitis B_Homo sapiens_hsa051611.37360172
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35239183
49Viral myocarditis_Homo sapiens_hsa054161.35022717
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.33854263
51Pertussis_Homo sapiens_hsa051331.32333795
52Basal transcription factors_Homo sapiens_hsa030221.30358263
53Asthma_Homo sapiens_hsa053101.27741553
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25430538
55ABC transporters_Homo sapiens_hsa020101.23941077
56Salmonella infection_Homo sapiens_hsa051321.23829379
57Rheumatoid arthritis_Homo sapiens_hsa053231.22232800
58Serotonergic synapse_Homo sapiens_hsa047261.20436051
59Toxoplasmosis_Homo sapiens_hsa051451.19058172
60Circadian entrainment_Homo sapiens_hsa047131.18986295
61Dorso-ventral axis formation_Homo sapiens_hsa043201.17517697
62Regulation of autophagy_Homo sapiens_hsa041401.16359610
63Malaria_Homo sapiens_hsa051441.15647340
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15473904
65Propanoate metabolism_Homo sapiens_hsa006401.12371212
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12031109
67Glutamatergic synapse_Homo sapiens_hsa047241.11922383
68Hepatitis C_Homo sapiens_hsa051601.11458266
69Apoptosis_Homo sapiens_hsa042101.05702682
70Shigellosis_Homo sapiens_hsa051311.04869929
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03791748
72Caffeine metabolism_Homo sapiens_hsa002321.00725402
73Neurotrophin signaling pathway_Homo sapiens_hsa047221.00312164
74Phagosome_Homo sapiens_hsa041450.98275278
75Fatty acid biosynthesis_Homo sapiens_hsa000610.97477893
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.97402378
77RNA degradation_Homo sapiens_hsa030180.97142789
78Acute myeloid leukemia_Homo sapiens_hsa052210.96663024
79Cocaine addiction_Homo sapiens_hsa050300.96399685
80African trypanosomiasis_Homo sapiens_hsa051430.96179100
81Colorectal cancer_Homo sapiens_hsa052100.94725016
82Peroxisome_Homo sapiens_hsa041460.94358473
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94242552
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93794147
85Chronic myeloid leukemia_Homo sapiens_hsa052200.92992468
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92565345
87Epstein-Barr virus infection_Homo sapiens_hsa051690.89955287
88Prolactin signaling pathway_Homo sapiens_hsa049170.87196449
89Pancreatic cancer_Homo sapiens_hsa052120.86762602
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.80719157
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79962039
92Cholinergic synapse_Homo sapiens_hsa047250.78012110
93Staphylococcus aureus infection_Homo sapiens_hsa051500.76182344
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75741009
95Viral carcinogenesis_Homo sapiens_hsa052030.75714017
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75003565
97Hedgehog signaling pathway_Homo sapiens_hsa043400.74187398
98Glycerolipid metabolism_Homo sapiens_hsa005610.74152233
99Synaptic vesicle cycle_Homo sapiens_hsa047210.72655084
100Olfactory transduction_Homo sapiens_hsa047400.71569616
101Endometrial cancer_Homo sapiens_hsa052130.71135491
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70233322
103Insulin secretion_Homo sapiens_hsa049110.70022298
104Oxidative phosphorylation_Homo sapiens_hsa001900.69032531
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68013776
106Calcium signaling pathway_Homo sapiens_hsa040200.66912105
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66307531
108Dopaminergic synapse_Homo sapiens_hsa047280.65478018
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65118657
110Salivary secretion_Homo sapiens_hsa049700.65017949
111Chemical carcinogenesis_Homo sapiens_hsa052040.64901808
112RNA polymerase_Homo sapiens_hsa030200.64703865
113HTLV-I infection_Homo sapiens_hsa051660.64009281
114cAMP signaling pathway_Homo sapiens_hsa040240.63681076
115Amphetamine addiction_Homo sapiens_hsa050310.63106577
116Non-small cell lung cancer_Homo sapiens_hsa052230.62889478
117Notch signaling pathway_Homo sapiens_hsa043300.62477110
118Spliceosome_Homo sapiens_hsa030400.61662825
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60902113
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60307540
121Long-term depression_Homo sapiens_hsa047300.59898503
122Steroid biosynthesis_Homo sapiens_hsa001000.59740906
123Protein export_Homo sapiens_hsa030600.59502314
124Morphine addiction_Homo sapiens_hsa050320.59232444
125Type II diabetes mellitus_Homo sapiens_hsa049300.58913742
126Arachidonic acid metabolism_Homo sapiens_hsa005900.57045917
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.56759844
128Proteasome_Homo sapiens_hsa030500.56752985
129Ovarian steroidogenesis_Homo sapiens_hsa049130.55690749
130Nicotine addiction_Homo sapiens_hsa050330.55670216
131Retinol metabolism_Homo sapiens_hsa008300.54742579
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53386781
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53098645
134Base excision repair_Homo sapiens_hsa034100.53052691
135Circadian rhythm_Homo sapiens_hsa047100.52849592
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.51027212
137Non-homologous end-joining_Homo sapiens_hsa034500.49979270
138Glioma_Homo sapiens_hsa052140.49642303
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47412779
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46343735
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.46316260
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46278401
143Oxytocin signaling pathway_Homo sapiens_hsa049210.46241693
144Collecting duct acid secretion_Homo sapiens_hsa049660.45576383
145Platelet activation_Homo sapiens_hsa046110.45269133
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45166703
147Lysosome_Homo sapiens_hsa041420.44941427
148Purine metabolism_Homo sapiens_hsa002300.43705880
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42615407
150DNA replication_Homo sapiens_hsa030300.42278229
151Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41867060
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40636542
153Gastric acid secretion_Homo sapiens_hsa049710.40406807
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39769583
155Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39691394
156Basal cell carcinoma_Homo sapiens_hsa052170.39336964
157Systemic lupus erythematosus_Homo sapiens_hsa053220.38619091
158Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37366124
159mTOR signaling pathway_Homo sapiens_hsa041500.37273395
160HIF-1 signaling pathway_Homo sapiens_hsa040660.35874412
161Cell cycle_Homo sapiens_hsa041100.34769324
162FoxO signaling pathway_Homo sapiens_hsa040680.34415415
163Alcoholism_Homo sapiens_hsa050340.33795261
164Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33542777
165Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32870165
166MicroRNAs in cancer_Homo sapiens_hsa052060.30340217
167MAPK signaling pathway_Homo sapiens_hsa040100.29941249

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