PARP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.21798488
2negative regulation of cell killing (GO:0031342)4.71787193
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.71787193
4positive regulation of interferon-alpha production (GO:0032727)4.64432974
5regulation of RIG-I signaling pathway (GO:0039535)4.47458297
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.38356078
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.38356078
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.38356078
9modulation by symbiont of host immune response (GO:0052553)4.38356078
10positive regulation by symbiont of host defense response (GO:0052509)4.38356078
11modulation by symbiont of host defense response (GO:0052031)4.38356078
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.36920834
13negative regulation of interleukin-12 production (GO:0032695)4.35413246
14regulation of interferon-alpha production (GO:0032647)4.35030784
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.30813702
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.30813702
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.03516901
18cellular response to virus (GO:0098586)4.03002965
19immunoglobulin mediated immune response (GO:0016064)3.95169252
20antigen processing and presentation of endogenous antigen (GO:0019883)3.92697420
21cellular response to type I interferon (GO:0071357)3.92048662
22type I interferon signaling pathway (GO:0060337)3.92048662
23response to interferon-alpha (GO:0035455)3.91295994
24response to type I interferon (GO:0034340)3.90053282
25regulation of gamma-delta T cell activation (GO:0046643)3.88979556
26detection of other organism (GO:0098543)3.86429420
27piRNA metabolic process (GO:0034587)3.83646675
28detection of bacterium (GO:0016045)3.75117014
29regulation of dendritic cell antigen processing and presentation (GO:0002604)3.75052525
30regulation of interferon-beta biosynthetic process (GO:0045357)3.55823327
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.53482467
32regulation of T cell tolerance induction (GO:0002664)3.52587616
33positive regulation of interferon-beta production (GO:0032728)3.51841089
34cellular response to interferon-alpha (GO:0035457)3.49058637
35regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.47168029
36regulation of mononuclear cell migration (GO:0071675)3.44192794
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.43635640
38T cell migration (GO:0072678)3.41273269
39negative regulation of T cell mediated immunity (GO:0002710)3.36788639
40defense response to protozoan (GO:0042832)3.35005808
41germinal center formation (GO:0002467)3.34114068
42natural killer cell mediated cytotoxicity (GO:0042267)3.31540162
43natural killer cell mediated immunity (GO:0002228)3.31540162
44detection of external biotic stimulus (GO:0098581)3.29120131
45regulation of antigen processing and presentation (GO:0002577)3.28448244
46regulation of gamma-delta T cell differentiation (GO:0045586)3.28083951
47negative regulation of cytokine production involved in immune response (GO:0002719)3.23122904
48regulation of B cell receptor signaling pathway (GO:0050855)3.19936708
49response to protozoan (GO:0001562)3.17423463
50regulation of tolerance induction (GO:0002643)3.16821439
51detection of molecule of bacterial origin (GO:0032490)3.14394691
52negative regulation of viral genome replication (GO:0045071)3.13501316
53leukocyte aggregation (GO:0070486)3.11659245
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.08226308
55response to peptidoglycan (GO:0032494)3.05139218
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.04853715
57regulation of female gonad development (GO:2000194)3.03622354
58myeloid dendritic cell activation (GO:0001773)3.02558034
59negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.97865337
60macrophage activation involved in immune response (GO:0002281)2.97690829
61growth hormone receptor signaling pathway (GO:0060396)2.97680576
62urea cycle (GO:0000050)2.96078815
63urea metabolic process (GO:0019627)2.96078815
64negative regulation of lipid storage (GO:0010888)2.96077812
65regulation of cholesterol storage (GO:0010885)2.94738479
66female gamete generation (GO:0007292)2.94089984
67interferon-gamma-mediated signaling pathway (GO:0060333)2.91628859
68regulation of type I interferon-mediated signaling pathway (GO:0060338)2.90756708
69response to interferon-gamma (GO:0034341)2.89520768
70cellular response to exogenous dsRNA (GO:0071360)2.88660154
71positive regulation of humoral immune response (GO:0002922)2.88519741
72regulation of type 2 immune response (GO:0002828)2.88480831
73B cell mediated immunity (GO:0019724)2.87466372
74regulation of T-helper 1 cell differentiation (GO:0045625)2.86845482
75regulation of macrophage chemotaxis (GO:0010758)2.86731830
76negative regulation of innate immune response (GO:0045824)2.86217491
77positive regulation of tolerance induction (GO:0002645)2.85796871
78myeloid cell activation involved in immune response (GO:0002275)2.84749036
79negative regulation of erythrocyte differentiation (GO:0045647)2.84327647
80detection of biotic stimulus (GO:0009595)2.83976888
81cellular extravasation (GO:0045123)2.82396189
82mitotic chromosome condensation (GO:0007076)2.81797489
83interferon-gamma secretion (GO:0072643)2.81649440
84negative regulation of leukocyte mediated immunity (GO:0002704)2.80041040
85T-helper 1 type immune response (GO:0042088)2.79895892
86regulation of regulatory T cell differentiation (GO:0045589)2.78289324
87positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.78105640
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77879983
89response to host immune response (GO:0052572)2.77879983
90response to host (GO:0075136)2.77582698
91response to host defenses (GO:0052200)2.77582698
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77582698
93regulation of interferon-beta production (GO:0032648)2.76416379
94positive regulation of natural killer cell differentiation (GO:0032825)2.76229972
95regulation of interleukin-12 production (GO:0032655)2.75512613
96negative thymic T cell selection (GO:0045060)2.74984580
97regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74931692
98granulocyte activation (GO:0036230)2.74677008
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73599577
100lymphocyte chemotaxis (GO:0048247)2.72287446
101positive regulation of Cdc42 GTPase activity (GO:0043089)2.72114000
102macrophage activation (GO:0042116)2.71713559
103regulation of hypersensitivity (GO:0002883)2.71491625
104regulation of interleukin-2 biosynthetic process (GO:0045076)2.71083113
105positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.69877993
106positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.69768466
107regulation of activation of Janus kinase activity (GO:0010533)2.68975318
108positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.68584983
109regulation of vitamin D biosynthetic process (GO:0060556)2.67955581
110tolerance induction (GO:0002507)2.66699216
111positive regulation of defense response to virus by host (GO:0002230)2.66445898
112neutrophil activation (GO:0042119)2.66418480
113regulation of T-helper 2 cell differentiation (GO:0045628)2.66146283
114triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.65071432
115dendritic cell differentiation (GO:0097028)2.63661295
116positive regulation of B cell differentiation (GO:0045579)2.63653010
117dendritic cell chemotaxis (GO:0002407)2.63048730
118regulation of necroptotic process (GO:0060544)2.63009619
119negative T cell selection (GO:0043383)2.62884955
120low-density lipoprotein particle clearance (GO:0034383)2.62172011
121nitrogen cycle metabolic process (GO:0071941)2.60547180
122neutrophil activation involved in immune response (GO:0002283)2.59203870
123NIK/NF-kappaB signaling (GO:0038061)2.57753879
124hydrogen peroxide biosynthetic process (GO:0050665)2.52023805
125positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.50631837
126positive regulation of interleukin-12 production (GO:0032735)2.49347355
127cellular response to growth hormone stimulus (GO:0071378)2.48344096
128regulation of defense response to virus by host (GO:0050691)2.47891285
129JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46950571
130histone H2A monoubiquitination (GO:0035518)2.46128586
131myeloid dendritic cell differentiation (GO:0043011)2.44177603
132positive regulation of T cell apoptotic process (GO:0070234)2.42121624
133complement activation, alternative pathway (GO:0006957)2.41758440
134regulation of cytokine secretion involved in immune response (GO:0002739)2.41424294
135production of molecular mediator involved in inflammatory response (GO:0002532)2.41085787
136peptidyl-glutamic acid carboxylation (GO:0017187)2.40664688
137protein carboxylation (GO:0018214)2.40664688
138meiotic cell cycle (GO:0051321)2.40663876
139response to interferon-beta (GO:0035456)2.40163440
140positive regulation of antigen processing and presentation (GO:0002579)2.38774313
141plasma lipoprotein particle clearance (GO:0034381)2.38030234
142defense response to virus (GO:0051607)2.37030876
143positive regulation of type 2 immune response (GO:0002830)2.36762248
144microglial cell activation (GO:0001774)2.35460420
145regulation of response to interferon-gamma (GO:0060330)2.35442992
146striated muscle atrophy (GO:0014891)2.32596676
147cellular response to interferon-gamma (GO:0071346)2.32205547
148regulation of interleukin-12 biosynthetic process (GO:0045075)2.31903434
149response to muramyl dipeptide (GO:0032495)2.30463709
150positive regulation of toll-like receptor signaling pathway (GO:0034123)2.30128364
151monoubiquitinated protein deubiquitination (GO:0035520)2.29135593
152positive regulation of chemokine biosynthetic process (GO:0045080)2.27775521
153DNA damage induced protein phosphorylation (GO:0006975)2.27650282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.64211467
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.47239439
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.07282422
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.68038238
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.40819340
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.24937011
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15286184
8* RXR_22158963_ChIP-Seq_LIVER_Mouse3.05468070
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.05105901
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.01408483
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69627039
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68879981
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.62736920
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.59212511
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54727575
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43613651
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38879082
18VDR_21846776_ChIP-Seq_THP-1_Human2.33763941
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.26531060
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24940339
21VDR_24763502_ChIP-Seq_THP-1_Human2.19013256
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14281103
23RUNX_20019798_ChIP-Seq_JUKART_Human2.14034350
24* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97298085
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96744438
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.94150805
27MYC_22102868_ChIP-Seq_BL_Human1.85169418
28SCL_19346495_ChIP-Seq_HPC-7_Human1.83376390
29* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.79170662
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.75215093
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70869355
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68322147
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67614643
34UTX_26944678_Chip-Seq_JUKART_Human1.66633364
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58643934
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.56515900
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52439754
38MAF_26560356_Chip-Seq_TH2_Human1.51896992
39FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.50481526
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.49254779
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.48332224
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48228852
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44803499
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44302730
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43509736
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.42249688
47* KDM2B_26808549_Chip-Seq_DND41_Human1.41978999
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40386285
49AR_21909140_ChIP-Seq_LNCAP_Human1.36388941
50LXR_22292898_ChIP-Seq_THP-1_Human1.33284413
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32403362
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.31913341
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31109659
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30912070
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27990390
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27114160
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25685486
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24556140
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24411765
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.24335730
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23609731
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.23199890
63GATA1_19941826_ChIP-Seq_K562_Human1.22604165
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20340172
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19900762
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19792144
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19255056
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15649364
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13746068
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13455642
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12628117
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11499017
73PU_27001747_Chip-Seq_BMDM_Mouse1.11447332
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11140252
75VDR_24787735_ChIP-Seq_THP-1_Human1.10959836
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.10675527
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10470387
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10163161
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09438183
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05591373
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05205010
82GATA1_22025678_ChIP-Seq_K562_Human1.04909658
83CJUN_26792858_Chip-Seq_BT549_Human1.04275450
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02759387
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01976977
86GATA6_25053715_ChIP-Seq_YYC3_Human1.01762897
87* MYB_26560356_Chip-Seq_TH2_Human1.01712650
88* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01534488
89MYB_26560356_Chip-Seq_TH1_Human1.01239544
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99037504
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98760488
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98035710
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97992220
94* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97816476
95BCL6_27268052_Chip-Seq_Bcells_Human0.97284272
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96506872
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95762536
98BCOR_27268052_Chip-Seq_Bcells_Human0.95755492
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.95699860
100SPI1_23547873_ChIP-Seq_NB4_Human0.95199015
101* RACK7_27058665_Chip-Seq_MCF-7_Human0.94506249
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94415666
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94405234
104GATA3_27048872_Chip-Seq_THYMUS_Human0.94380202
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94113948
106GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93239635
107* GATA4_25053715_ChIP-Seq_YYC3_Human0.92737029
108STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92717255
109* SOX2_20726797_ChIP-Seq_SW620_Human0.92185250
110* NCOR1_26117541_ChIP-Seq_K562_Human0.92029850
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90460662
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90227565
113MAF_26560356_Chip-Seq_TH1_Human0.89963793
114* GATA3_26560356_Chip-Seq_TH2_Human0.88266123
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.87645279
116CDX2_22108803_ChIP-Seq_LS180_Human0.86772350
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86475234
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86023608
119GATA2_19941826_ChIP-Seq_K562_Human0.85962696
120TFEB_21752829_ChIP-Seq_HELA_Human0.85185714
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84875151
122STAT1_20625510_ChIP-Seq_HELA_Human0.84703164
123SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84552357
124* FOXA2_19822575_ChIP-Seq_HepG2_Human0.84389113
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84174987
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83548152
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.83203934
128TCF7_22412390_ChIP-Seq_EML_Mouse0.81377551
129* TP63_23658742_ChIP-Seq_EP156T_Human0.81101122
130* ATF3_27146783_Chip-Seq_COLON_Human0.78097444
131PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77677229
132RUNX1_22412390_ChIP-Seq_EML_Mouse0.77056026
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76606808
134STAT1_17558387_ChIP-Seq_HELA_Human0.75655650
135CLOCK_20551151_ChIP-Seq_293T_Human0.75440274
136GATA3_26560356_Chip-Seq_TH1_Human0.75122694
137SPI1_23127762_ChIP-Seq_K562_Human0.74738742
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74042201
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.73555151
140SOX2_27498859_Chip-Seq_STOMACH_Mouse0.73309811
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73243616
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.72338012
143* SMRT_27268052_Chip-Seq_Bcells_Human0.71757612
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.71305375
145ESR1_21235772_ChIP-Seq_MCF-7_Human0.71194948
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.70795313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.21920519
2MP0002139_abnormal_hepatobiliary_system3.05166953
3MP0009840_abnormal_foam_cell3.04537218
4MP0005451_abnormal_body_composition2.96217399
5MP0001835_abnormal_antigen_presentation2.86071717
6MP0009785_altered_susceptibility_to2.62446261
7MP0003718_maternal_effect2.51339011
8MP0003724_increased_susceptibility_to2.36548532
9MP0003646_muscle_fatigue2.30102537
10MP0003436_decreased_susceptibility_to2.25502333
11MP0006082_CNS_inflammation2.20681958
12MP0005365_abnormal_bile_salt2.08903592
13MP0004510_myositis2.04571490
14MP0003303_peritoneal_inflammation2.03428698
15MP0003191_abnormal_cellular_cholesterol2.00365689
16MP0003763_abnormal_thymus_physiology1.98371301
17MP0003705_abnormal_hypodermis_morpholog1.95622852
18MP0000685_abnormal_immune_system1.95284293
19MP0005085_abnormal_gallbladder_physiolo1.94792418
20MP0005310_abnormal_salivary_gland1.85970755
21MP0005025_abnormal_response_to1.85393290
22MP0002419_abnormal_innate_immunity1.82338522
23MP0008875_abnormal_xenobiotic_pharmacok1.80101644
24MP0005408_hypopigmentation1.76871599
25MP0003172_abnormal_lysosome_physiology1.76673086
26MP0003252_abnormal_bile_duct1.76596936
27MP0005387_immune_system_phenotype1.73699656
28MP0001790_abnormal_immune_system1.73699656
29MP0002148_abnormal_hypersensitivity_rea1.72050767
30MP0005058_abnormal_lysosome_morphology1.71724501
31MP0005000_abnormal_immune_tolerance1.67842739
32MP0009764_decreased_sensitivity_to1.66088056
33MP0002877_abnormal_melanocyte_morpholog1.56527267
34MP0004947_skin_inflammation1.55616739
35MP0010307_abnormal_tumor_latency1.55520010
36MP0005395_other_phenotype1.52925615
37MP0002138_abnormal_hepatobiliary_system1.52004785
38MP0002452_abnormal_antigen_presenting1.50963882
39MP0001800_abnormal_humoral_immune1.48274708
40MP0010234_abnormal_vibrissa_follicle1.44827439
41MP0005464_abnormal_platelet_physiology1.43544117
42MP0002723_abnormal_immune_serum1.43436511
43MP0004185_abnormal_adipocyte_glucose1.42224562
44MP0003806_abnormal_nucleotide_metabolis1.41846648
45MP0005671_abnormal_response_to1.39989327
46MP0008260_abnormal_autophagy1.38261898
47MP0004782_abnormal_surfactant_physiolog1.35185288
48MP0003453_abnormal_keratinocyte_physiol1.34520621
49MP0002006_tumorigenesis1.34500804
50MP0008469_abnormal_protein_level1.34470507
51MP0003183_abnormal_peptide_metabolism1.32230224
52MP0002998_abnormal_bone_remodeling1.31747139
53MP0000609_abnormal_liver_physiology1.31361615
54MP0002429_abnormal_blood_cell1.30500694
55MP0001533_abnormal_skeleton_physiology1.29908894
56MP0001873_stomach_inflammation1.29560988
57MP0001845_abnormal_inflammatory_respons1.29249990
58MP0001545_abnormal_hematopoietic_system1.28958263
59MP0005397_hematopoietic_system_phenotyp1.28958263
60MP0002722_abnormal_immune_system1.27827976
61MP0000465_gastrointestinal_hemorrhage1.25834441
62MP0003866_abnormal_defecation1.24778969
63MP0010329_abnormal_lipoprotein_level1.24766710
64MP0005166_decreased_susceptibility_to1.22373267
65MP0010155_abnormal_intestine_physiology1.22114601
66MP0008004_abnormal_stomach_pH1.20865198
67MP0003448_altered_tumor_morphology1.20359688
68MP0001819_abnormal_immune_cell1.18675467
69MP0009763_increased_sensitivity_to1.16808950
70MP0001119_abnormal_female_reproductive1.16634800
71MP0000343_altered_response_to1.15357562
72MP0002420_abnormal_adaptive_immunity1.12800527
73MP0001915_intracranial_hemorrhage1.12309219
74MP0003828_pulmonary_edema1.10117618
75MP0005257_abnormal_intraocular_pressure1.09088648
76MP0010368_abnormal_lymphatic_system1.09076486
77MP0001851_eye_inflammation1.09065658
78MP0003699_abnormal_female_reproductive1.08617930
79MP0003186_abnormal_redox_activity1.08593043
80MP0009278_abnormal_bone_marrow1.07919519
81MP0003300_gastrointestinal_ulcer1.06874919
82MP0002405_respiratory_system_inflammati1.04223126
83MP0003091_abnormal_cell_migration1.02505269
84MP0009333_abnormal_splenocyte_physiolog1.00832019
85MP0005167_abnormal_blood-brain_barrier1.00156601
86MP0000703_abnormal_thymus_morphology0.99248199
87MP0002254_reproductive_system_inflammat0.99177518
88MP0005164_abnormal_response_to0.97909139
89MP0003690_abnormal_glial_cell0.96270718
90MP0000604_amyloidosis0.95313648
91MP0005076_abnormal_cell_differentiation0.94810632
92MP0003195_calcinosis0.94577874
93MP0004883_abnormal_blood_vessel0.94321498
94MP0005083_abnormal_biliary_tract0.92598823
95MP0005023_abnormal_wound_healing0.91505371
96MP0004808_abnormal_hematopoietic_stem0.90773563
97MP0001663_abnormal_digestive_system0.90623030
98MP0002332_abnormal_exercise_endurance0.90119465
99MP0000716_abnormal_immune_system0.89626194
100MP0000579_abnormal_nail_morphology0.89589915
101MP0004264_abnormal_extraembryonic_tissu0.86495767
102MP0001666_abnormal_nutrient_absorption0.86459020
103MP0003075_altered_response_to0.85826519
104MP0000767_abnormal_smooth_muscle0.84554615
105MP0000598_abnormal_liver_morphology0.83898202
106MP0002398_abnormal_bone_marrow0.83806595
107MP0000858_altered_metastatic_potential0.83265072
108MP0005647_abnormal_sex_gland0.82502944
109MP0001853_heart_inflammation0.82424495
110MP0003566_abnormal_cell_adhesion0.82079878
111MP0003693_abnormal_embryo_hatching0.81844848
112MP0002166_altered_tumor_susceptibility0.81528291
113MP0005319_abnormal_enzyme/_coenzyme0.81162430
114MP0005390_skeleton_phenotype0.80850989
115MP0000490_abnormal_crypts_of0.78161378
116MP0002277_abnormal_respiratory_mucosa0.77756276
117MP0002933_joint_inflammation0.76677064
118MP0002168_other_aberrant_phenotype0.76449985
119MP0003656_abnormal_erythrocyte_physiolo0.76363277
120MP0001849_ear_inflammation0.75856800
121MP0000689_abnormal_spleen_morphology0.75552178
122MP0002118_abnormal_lipid_homeostasis0.75303871
123MP0010352_gastrointestinal_tract_polyps0.75206106
124MP0001881_abnormal_mammary_gland0.74817598
125MP0000249_abnormal_blood_vessel0.73033699
126MP0002653_abnormal_ependyma_morphology0.71406183
127MP0002132_abnormal_respiratory_system0.70350024
128MP0003795_abnormal_bone_structure0.66356932
129MP0004381_abnormal_hair_follicle0.64310585
130MP0006054_spinal_hemorrhage0.64117263
131MP0002396_abnormal_hematopoietic_system0.63603380
132MP0003045_fibrosis0.63058513
133MP0009765_abnormal_xenobiotic_induced0.63048096
134MP0008874_decreased_physiological_sensi0.62645941
135MP0005381_digestive/alimentary_phenotyp0.53650296

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)5.01513924
2Recurrent bacterial skin infections (HP:0005406)4.44535012
3Male infertility (HP:0003251)4.33040958
4Recurrent gram-negative bacterial infections (HP:0005420)4.31643651
5Stomatitis (HP:0010280)4.18722368
6Recurrent abscess formation (HP:0002722)4.13129869
7Eczematoid dermatitis (HP:0000976)4.13016022
8Deep venous thrombosis (HP:0002625)4.04984418
9Systemic lupus erythematosus (HP:0002725)3.91881718
10Myocardial infarction (HP:0001658)3.76367577
11Prostate neoplasm (HP:0100787)3.62684318
12Loss of speech (HP:0002371)3.36934395
13Keratoconjunctivitis sicca (HP:0001097)3.28900290
14Gastrointestinal infarctions (HP:0005244)3.27849984
15Complement deficiency (HP:0004431)3.21833301
16Meningitis (HP:0001287)3.18664320
17Recurrent cutaneous fungal infections (HP:0011370)3.18482314
18Chronic mucocutaneous candidiasis (HP:0002728)3.18482314
19Tetraparesis (HP:0002273)3.17287092
20Intrahepatic cholestasis (HP:0001406)3.10613178
21Hemoptysis (HP:0002105)3.09045336
22Chronic obstructive pulmonary disease (HP:0006510)3.08226985
23Obstructive lung disease (HP:0006536)3.08226985
24Myositis (HP:0100614)3.05932248
25Esophageal varix (HP:0002040)3.01881217
26Orchitis (HP:0100796)3.01171064
27T lymphocytopenia (HP:0005403)3.01004707
28Cortical dysplasia (HP:0002539)3.00189975
29Keratoconjunctivitis (HP:0001096)2.97040342
30Papillary thyroid carcinoma (HP:0002895)2.93300222
31Spontaneous abortion (HP:0005268)2.93173583
32Increased cerebral lipofuscin (HP:0011813)2.92249826
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.91382141
34Abnormality of T cell number (HP:0011839)2.90899625
35Encephalitis (HP:0002383)2.89416418
36Dysostosis multiplex (HP:0000943)2.88151627
37Abnormality of macrophages (HP:0004311)2.81369046
38Glomerulonephritis (HP:0000099)2.78645001
39Recurrent skin infections (HP:0001581)2.76332655
40Increased IgE level (HP:0003212)2.74236529
41Xanthomatosis (HP:0000991)2.72247990
42Polycythemia (HP:0001901)2.69804002
43Peritonitis (HP:0002586)2.69509992
44Abnormality of the nasal mucosa (HP:0000433)2.66796783
45Hematochezia (HP:0002573)2.65994811
46Elevated erythrocyte sedimentation rate (HP:0003565)2.65279427
47Nephritis (HP:0000123)2.65273910
48Nasal polyposis (HP:0100582)2.64165405
49Joint hemorrhage (HP:0005261)2.63622681
50Mediastinal lymphadenopathy (HP:0100721)2.59716758
51Retrobulbar optic neuritis (HP:0100654)2.59070424
52Optic neuritis (HP:0100653)2.59070424
53Urticaria (HP:0001025)2.58614838
54Cellulitis (HP:0100658)2.54504623
55Colitis (HP:0002583)2.54425625
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.53347110
57Vasculitis (HP:0002633)2.50794196
58Chronic otitis media (HP:0000389)2.50068436
59Gingival bleeding (HP:0000225)2.48864428
60Inflammation of the large intestine (HP:0002037)2.48662585
61Increased serum ferritin (HP:0003281)2.46750021
62Gastrointestinal inflammation (HP:0004386)2.45702949
63Pustule (HP:0200039)2.45621105
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.45261578
65Arterial thrombosis (HP:0004420)2.42093827
66Acute myeloid leukemia (HP:0004808)2.42057496
67Abnormality of complement system (HP:0005339)2.40921721
68Gangrene (HP:0100758)2.40452314
69Abnormality of glutamine family amino acid metabolism (HP:0010902)2.40384596
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.39387844
71Abnormality of the common coagulation pathway (HP:0010990)2.37421770
72Hemorrhage of the eye (HP:0011885)2.37278915
73Purpura (HP:0000979)2.36435353
74Disinhibition (HP:0000734)2.35039542
75Recurrent bronchitis (HP:0002837)2.32106082
76Pulmonary embolism (HP:0002204)2.31685643
77Abnormality of the fingertips (HP:0001211)2.31238433
78Chest pain (HP:0100749)2.30726430
79Increased IgM level (HP:0003496)2.29334665
80Epidermoid cyst (HP:0200040)2.28335334
81Petechiae (HP:0000967)2.27120421
82Hypoalphalipoproteinemia (HP:0003233)2.26704556
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.24552089
84Abnormality of T cells (HP:0002843)2.24217681
85Gingivitis (HP:0000230)2.22916381
86Osteomyelitis (HP:0002754)2.20559994
87Abnormality of polysaccharide metabolism (HP:0011012)2.20183190
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20183190
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20183190
90Prolonged bleeding time (HP:0003010)2.19749332
91Epistaxis (HP:0000421)2.18903752
92Interstitial pulmonary disease (HP:0006530)2.18415796
93Abnormality of the pleura (HP:0002103)2.16706965
94Abnormality of lateral ventricle (HP:0030047)2.16494369
95Recurrent viral infections (HP:0004429)2.16406093
96Recurrent fungal infections (HP:0002841)2.15989903
97Periodontitis (HP:0000704)2.15655314
98Basal ganglia calcification (HP:0002135)2.15211196
99Abnormality of iron homeostasis (HP:0011031)2.14102961
100Hypercholesterolemia (HP:0003124)2.13838887
101Joint swelling (HP:0001386)2.13541968
102Mucopolysacchariduria (HP:0008155)2.12829929
103Urinary glycosaminoglycan excretion (HP:0003541)2.12829929
104Osteolytic defects of the hand bones (HP:0009699)2.11108293
105Osteolytic defects of the phalanges of the hand (HP:0009771)2.11108293
106Cheilitis (HP:0100825)2.10221881
107Pulmonary infiltrates (HP:0002113)2.10033902
108Gastrointestinal stroma tumor (HP:0100723)2.09270891
109Prolonged partial thromboplastin time (HP:0003645)2.06162057
110Abnormality of the prostate (HP:0008775)2.06109107
111Hypolipoproteinemia (HP:0010981)2.04095631
112Sensorimotor neuropathy (HP:0007141)2.03984705
113Granulocytopenia (HP:0001913)2.03098136
114Hypobetalipoproteinemia (HP:0003563)2.02677531
115Abnormality of purine metabolism (HP:0004352)2.02133621
116Abnormality of the vasculature of the conjunctiva (HP:0008054)2.01542882
117Abnormality of the endocardium (HP:0004306)2.01174944
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01165600
119Thick nail (HP:0001805)2.00494304
120Chronic diarrhea (HP:0002028)1.99928124
121Episodic fever (HP:0001954)1.99555607
122Abnormality of sulfur amino acid metabolism (HP:0004339)1.99216966
123Polyneuropathy (HP:0001271)1.99200345
124Glomerulopathy (HP:0100820)1.98467272
125Panhypogammaglobulinemia (HP:0003139)1.97587670
126Abnormality of glycolipid metabolism (HP:0010969)1.97074640
127Abnormality of liposaccharide metabolism (HP:0010968)1.97074640
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.97074640
129Acne (HP:0001061)1.94749935
130Amyloidosis (HP:0011034)1.94634766
131Fat malabsorption (HP:0002630)1.94232019
132Axonal loss (HP:0003447)1.94217270
133Hepatosplenomegaly (HP:0001433)1.93928349
134Thrombophlebitis (HP:0004418)1.93609711
135Lymphopenia (HP:0001888)1.92017118
136Hyperglycemia (HP:0003074)1.91242361
137Abnormality of the intrinsic pathway (HP:0010989)1.91083736
138Spontaneous hematomas (HP:0007420)1.90847984
139Autoimmune hemolytic anemia (HP:0001890)1.90292296
140Arthralgia (HP:0002829)1.89654383
141Skin ulcer (HP:0200042)1.89215163
142Abnormality of the hepatic vasculature (HP:0006707)1.88887679
143Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87929500
144Vacuolated lymphocytes (HP:0001922)1.87464570
145Conjunctival telangiectasia (HP:0000524)1.86817889
146Hyperlipoproteinemia (HP:0010980)1.86349552
147Pigmentary retinal degeneration (HP:0001146)1.85303523
148Leukocytosis (HP:0001974)1.84115861
149Arterial tortuosity (HP:0005116)1.83095313
150Abnormality of proline metabolism (HP:0010907)1.82799840
151Hydroxyprolinuria (HP:0003080)1.82799840
152Anorexia (HP:0002039)1.82622699
153Hypergammaglobulinemia (HP:0010702)1.80048977
154Malnutrition (HP:0004395)1.78806619
155Abnormality of nucleobase metabolism (HP:0010932)1.77956379
156Porencephaly (HP:0002132)1.77050040
157Insulin-resistant diabetes mellitus (HP:0000831)1.76073096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.70561777
2TAOK33.93273314
3TYK22.91986871
4LATS22.91011473
5MAP3K62.79535093
6STK38L2.73423211
7MAP3K132.72637440
8PRPF4B2.72569753
9KSR22.59620572
10ERBB42.58725386
11JAK32.51133616
12MOS2.34938628
13TBK12.30608412
14STK32.25492213
15IKBKE2.15405008
16MAP3K142.13131041
17MAP2K32.05583637
18BMPR21.85017310
19TXK1.80851822
20MAP3K31.75088820
21TAOK21.74431987
22ERN11.70879115
23JAK11.65366205
24NME21.60817719
25KIT1.60532534
26BTK1.60383103
27FGFR41.58484014
28PLK41.57747138
29ABL21.54942758
30MAP3K111.54676706
31GRK71.51087701
32FES1.47352064
33TRIB31.46743647
34ARAF1.38867309
35SYK1.35419345
36TAOK11.34959600
37MAP3K91.33635652
38RAF11.32870558
39PBK1.27361448
40STK101.27178532
41ACVR1B1.23021225
42CDC42BPA1.21763462
43LCK1.17009608
44EPHA31.16992099
45TEC1.16954587
46NEK91.16571597
47IKBKB1.16355162
48LYN1.16173732
49SIK31.14078587
50TNK21.13284088
51ITK1.12817021
52JAK21.09273181
53CHUK1.09257771
54GRK61.08594731
55EEF2K1.07561938
56MST1R1.07394887
57CDK81.04578580
58CDK91.04145667
59NEK21.00804295
60RPS6KA40.99100463
61MELK0.98198806
62PRKD30.96277808
63MAP3K50.95254242
64CDK120.95090401
65NLK0.93796846
66RIPK40.92375701
67FGFR30.92078562
68IRAK10.91766697
69DMPK0.89128836
70EPHB10.87414279
71BRAF0.86823774
72CDC70.86372858
73MAPK110.85997043
74PKN20.85797349
75RIPK10.84352512
76RET0.83935978
77IRAK40.80171417
78TTK0.79576415
79PRKAA20.76335849
80ABL10.76259787
81NUAK10.73465827
82BLK0.73435714
83MUSK0.73245352
84CSK0.72592424
85PDPK10.71104721
86CAMK1D0.69907193
87IRAK30.68516443
88PDK10.68453024
89PIM10.68111260
90MAPKAPK30.67764284
91IRAK20.66027736
92MAP3K10.66010152
93SMG10.65755735
94DDR20.65273865
95MAP3K80.64485609
96ZAP700.64184717
97BMX0.63491306
98FRK0.59368880
99MARK20.58931401
100TGFBR20.57086977
101CDK40.55975925
102DYRK20.53914815
103YES10.53568435
104PTK60.53256617
105PIM20.52911831
106CHEK20.52850149
107FLT30.52809261
108STK40.52641296
109STK240.52620229
110TESK20.51816373
111PRKAA10.50978127
112MAP4K10.50515089
113STK380.49459247
114MAP2K60.48544669
115MAPK70.45883401
116FGR0.45710864
117TRPM70.44924004
118FYN0.41817238
119CDK60.41522485
120TYRO30.40630536
121PTK20.37979301
122CSF1R0.37719929
123TIE10.37278821
124MAP3K100.36544159
125HCK0.36467366
126LRRK20.36040380
127HIPK20.35429471
128PRKCQ0.35169463
129MAPKAPK20.34915140
130PDGFRB0.33875179
131MARK30.33673209
132SIK20.33157006
133RPS6KC10.33106163
134RPS6KL10.33106163
135MATK0.31361525
136CAMKK20.30681806
137CLK10.30183316
138PRKD20.30129623
139KSR10.28086985
140TTN0.27480531
141EGFR0.27125784
142SIK10.25675796
143MAPK120.25607750

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.97383959
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.28370747
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22154437
4Leishmaniasis_Homo sapiens_hsa051402.13245173
5Caffeine metabolism_Homo sapiens_hsa002322.07163374
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06500858
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.00652791
8Complement and coagulation cascades_Homo sapiens_hsa046101.99026333
9Influenza A_Homo sapiens_hsa051641.96198882
10Primary immunodeficiency_Homo sapiens_hsa053401.87546592
11Arginine biosynthesis_Homo sapiens_hsa002201.82231058
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75733997
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74053721
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.69874297
15Herpes simplex infection_Homo sapiens_hsa051681.67591869
16Malaria_Homo sapiens_hsa051441.66502235
17Allograft rejection_Homo sapiens_hsa053301.64426057
18TNF signaling pathway_Homo sapiens_hsa046681.64083841
19Measles_Homo sapiens_hsa051621.63139578
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59742842
21Hematopoietic cell lineage_Homo sapiens_hsa046401.56751529
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55160810
23Graft-versus-host disease_Homo sapiens_hsa053321.52080581
24Nitrogen metabolism_Homo sapiens_hsa009101.43380619
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.43142716
26Pancreatic cancer_Homo sapiens_hsa052121.42996963
27Pertussis_Homo sapiens_hsa051331.41356687
28Osteoclast differentiation_Homo sapiens_hsa043801.41098277
29T cell receptor signaling pathway_Homo sapiens_hsa046601.39268550
30Toxoplasmosis_Homo sapiens_hsa051451.38279305
31Prolactin signaling pathway_Homo sapiens_hsa049171.28920746
32Ovarian steroidogenesis_Homo sapiens_hsa049131.22646931
33Tuberculosis_Homo sapiens_hsa051521.22527491
34Legionellosis_Homo sapiens_hsa051341.22414944
35Tryptophan metabolism_Homo sapiens_hsa003801.19648147
36Dorso-ventral axis formation_Homo sapiens_hsa043201.19253145
37Phagosome_Homo sapiens_hsa041451.19223513
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15696882
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.10341376
40Hepatitis C_Homo sapiens_hsa051601.09854704
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09497549
42Hepatitis B_Homo sapiens_hsa051611.05565145
43Folate biosynthesis_Homo sapiens_hsa007901.03656416
44PPAR signaling pathway_Homo sapiens_hsa033201.00909344
45Histidine metabolism_Homo sapiens_hsa003400.98025764
46Fatty acid degradation_Homo sapiens_hsa000710.95813868
47Apoptosis_Homo sapiens_hsa042100.95757697
48African trypanosomiasis_Homo sapiens_hsa051430.94144975
49Shigellosis_Homo sapiens_hsa051310.94038081
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93757703
51Peroxisome_Homo sapiens_hsa041460.90936493
52Antigen processing and presentation_Homo sapiens_hsa046120.85502029
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85475800
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.82815182
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82809802
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.82419314
57Small cell lung cancer_Homo sapiens_hsa052220.80332630
58Salmonella infection_Homo sapiens_hsa051320.79648898
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79180519
60Rheumatoid arthritis_Homo sapiens_hsa053230.78464237
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.77408223
62Lysosome_Homo sapiens_hsa041420.76735377
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76472695
64Chronic myeloid leukemia_Homo sapiens_hsa052200.76267137
65Epstein-Barr virus infection_Homo sapiens_hsa051690.76174993
66Amoebiasis_Homo sapiens_hsa051460.74869776
67Chemokine signaling pathway_Homo sapiens_hsa040620.74760209
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72714997
69p53 signaling pathway_Homo sapiens_hsa041150.71785344
70VEGF signaling pathway_Homo sapiens_hsa043700.70995020
71B cell receptor signaling pathway_Homo sapiens_hsa046620.70027289
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69973233
73Other glycan degradation_Homo sapiens_hsa005110.69939386
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69167486
75Type I diabetes mellitus_Homo sapiens_hsa049400.68819830
76Viral myocarditis_Homo sapiens_hsa054160.68031058
77TGF-beta signaling pathway_Homo sapiens_hsa043500.67857967
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67571626
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66779935
80MicroRNAs in cancer_Homo sapiens_hsa052060.66763924
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66592495
82Linoleic acid metabolism_Homo sapiens_hsa005910.65607411
83Insulin resistance_Homo sapiens_hsa049310.63106029
84Platelet activation_Homo sapiens_hsa046110.60430196
85Bile secretion_Homo sapiens_hsa049760.59844328
86Cell cycle_Homo sapiens_hsa041100.59027139
87Asthma_Homo sapiens_hsa053100.58465777
88ABC transporters_Homo sapiens_hsa020100.57274517
89Prion diseases_Homo sapiens_hsa050200.57071115
90beta-Alanine metabolism_Homo sapiens_hsa004100.56262067
91Selenocompound metabolism_Homo sapiens_hsa004500.56084932
92Lysine degradation_Homo sapiens_hsa003100.55240296
93Adherens junction_Homo sapiens_hsa045200.54981171
94Viral carcinogenesis_Homo sapiens_hsa052030.53940240
95Non-small cell lung cancer_Homo sapiens_hsa052230.53933758
96HTLV-I infection_Homo sapiens_hsa051660.53908487
97Fat digestion and absorption_Homo sapiens_hsa049750.53379722
98Chemical carcinogenesis_Homo sapiens_hsa052040.53072538
99Vitamin B6 metabolism_Homo sapiens_hsa007500.51635398
100mTOR signaling pathway_Homo sapiens_hsa041500.50880002
101Pentose phosphate pathway_Homo sapiens_hsa000300.50847248
102Starch and sucrose metabolism_Homo sapiens_hsa005000.50197237
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49789495
104Acute myeloid leukemia_Homo sapiens_hsa052210.49276314
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.49021000
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.48848999
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47930111
108Circadian rhythm_Homo sapiens_hsa047100.47816697
109Autoimmune thyroid disease_Homo sapiens_hsa053200.47555675
110Bladder cancer_Homo sapiens_hsa052190.47231576
111Retinol metabolism_Homo sapiens_hsa008300.47201277
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46776503
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.45697842
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45088327
115FoxO signaling pathway_Homo sapiens_hsa040680.44622678
116Mineral absorption_Homo sapiens_hsa049780.43223882
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42809288
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.42346667
119Vitamin digestion and absorption_Homo sapiens_hsa049770.42258874
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42151659
121Renal cell carcinoma_Homo sapiens_hsa052110.40254032
122Notch signaling pathway_Homo sapiens_hsa043300.39834104
123HIF-1 signaling pathway_Homo sapiens_hsa040660.39311692
124Endocytosis_Homo sapiens_hsa041440.37608430
125Fructose and mannose metabolism_Homo sapiens_hsa000510.36350250
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36064628
127Galactose metabolism_Homo sapiens_hsa000520.35397921
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35024726
129Renin-angiotensin system_Homo sapiens_hsa046140.32769899
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29774049
131Type II diabetes mellitus_Homo sapiens_hsa049300.29500133
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29093082
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.28056666
134Sphingolipid metabolism_Homo sapiens_hsa006000.25703783
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21584899
136Systemic lupus erythematosus_Homo sapiens_hsa053220.20638076
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19578191
138GnRH signaling pathway_Homo sapiens_hsa049120.18286224
139Choline metabolism in cancer_Homo sapiens_hsa052310.18062221
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.16297311

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