PARP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)6.45291614
2regulation of isotype switching to IgG isotypes (GO:0048302)5.85613525
3regulation of B cell receptor signaling pathway (GO:0050855)5.69522281
4positive regulation of gamma-delta T cell activation (GO:0046645)4.77408582
5interferon-gamma production (GO:0032609)4.67790037
6positive regulation of isotype switching (GO:0045830)4.67618665
7cellular response to exogenous dsRNA (GO:0071360)4.31840293
8positive regulation of DNA recombination (GO:0045911)4.24522176
9neural tube formation (GO:0001841)3.97169663
10regulation of gamma-delta T cell activation (GO:0046643)3.91575498
11lens fiber cell development (GO:0070307)3.87580593
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.85618068
13regulation of gamma-delta T cell differentiation (GO:0045586)3.81599419
14negative T cell selection (GO:0043383)3.66681934
15B cell receptor signaling pathway (GO:0050853)3.66185583
16positive regulation of B cell mediated immunity (GO:0002714)3.63027235
17positive regulation of immunoglobulin mediated immune response (GO:0002891)3.63027235
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61604066
19negative regulation of cell killing (GO:0031342)3.60694168
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.60694168
21dopamine transport (GO:0015872)3.60104351
22negative thymic T cell selection (GO:0045060)3.59574384
23leukotriene biosynthetic process (GO:0019370)3.47085633
24mast cell degranulation (GO:0043303)3.46127477
25mast cell activation involved in immune response (GO:0002279)3.46127477
26positive regulation of defense response to virus by host (GO:0002230)3.43140408
27regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.40028614
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38405792
29antigen processing and presentation of endogenous antigen (GO:0019883)3.32108803
30mast cell activation (GO:0045576)3.30963267
31positive regulation of immunoglobulin production (GO:0002639)3.26990296
32regulation of isotype switching (GO:0045191)3.15916115
33negative regulation of T-helper cell differentiation (GO:0045623)3.12301315
34negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.12301315
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.10092263
36cellular response to interleukin-15 (GO:0071350)3.07350898
37regulation of germinal center formation (GO:0002634)3.06066538
38indole-containing compound catabolic process (GO:0042436)3.04667455
39indolalkylamine catabolic process (GO:0046218)3.04667455
40tryptophan catabolic process (GO:0006569)3.04667455
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.03469381
42lymphocyte migration (GO:0072676)3.01256650
43positive regulation of developmental pigmentation (GO:0048087)3.00764249
44regulation of B cell mediated immunity (GO:0002712)2.96914105
45positive regulation of calcium-mediated signaling (GO:0050850)2.96349926
46regulation of immunoglobulin mediated immune response (GO:0002889)2.96057650
47monoubiquitinated protein deubiquitination (GO:0035520)2.95006518
48histamine transport (GO:0051608)2.93209529
49indolalkylamine metabolic process (GO:0006586)2.93167453
50regulation of B cell differentiation (GO:0045577)2.89557270
51positive regulation of granulocyte differentiation (GO:0030854)2.89343830
52toxin transport (GO:1901998)2.89279696
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88533259
54response to interleukin-15 (GO:0070672)2.88460353
55regulation of necroptotic process (GO:0060544)2.85482941
56regulation of alpha-beta T cell proliferation (GO:0046640)2.84917226
57T cell migration (GO:0072678)2.84513801
58antigen receptor-mediated signaling pathway (GO:0050851)2.83477839
59regulation of interleukin-12 biosynthetic process (GO:0045075)2.81297050
60positive T cell selection (GO:0043368)2.80987384
61regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.79196244
62positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.79196244
63cellular response to ethanol (GO:0071361)2.78834345
64negative regulation of calcium ion transport into cytosol (GO:0010523)2.78439825
65signal peptide processing (GO:0006465)2.76049449
66macrophage activation involved in immune response (GO:0002281)2.75876083
67T cell selection (GO:0045058)2.75603873
68interkinetic nuclear migration (GO:0022027)2.75264366
69cytoplasmic mRNA processing body assembly (GO:0033962)2.74022117
70negative regulation of T cell mediated immunity (GO:0002710)2.72788036
71negative regulation of B cell proliferation (GO:0030889)2.72520248
72regulation of MHC class I biosynthetic process (GO:0045343)2.72457259
73negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.72069912
74positive regulation of mRNA catabolic process (GO:0061014)2.69900679
75negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.69511524
76negative regulation of translation, ncRNA-mediated (GO:0040033)2.69511524
77regulation of translation, ncRNA-mediated (GO:0045974)2.69511524
78microglial cell activation (GO:0001774)2.68298636
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67786818
80negative regulation of lymphocyte mediated immunity (GO:0002707)2.66379883
81positive regulation of T cell cytokine production (GO:0002726)2.64694535
82NAD biosynthetic process (GO:0009435)2.63403281
83pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.63304089
84UMP biosynthetic process (GO:0006222)2.63304089
85pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.63304089
86UMP metabolic process (GO:0046049)2.63304089
87negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.63279258
88kynurenine metabolic process (GO:0070189)2.62581672
89positive thymic T cell selection (GO:0045059)2.60642151
90regulation of establishment of cell polarity (GO:2000114)2.59906452
91positive regulation of B cell activation (GO:0050871)2.59173043
92T cell proliferation (GO:0042098)2.58159724
93regulation of regulatory T cell differentiation (GO:0045589)2.57768856
94leukocyte aggregation (GO:0070486)2.57689601
95positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.57422670
96response to type I interferon (GO:0034340)2.57325274
97positive regulation of lymphocyte mediated immunity (GO:0002708)2.57133278
98positive regulation of B cell differentiation (GO:0045579)2.54016316
99regulation of pigment cell differentiation (GO:0050932)2.53184202
100tryptophan metabolic process (GO:0006568)2.52072539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.23951169
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.73862663
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.75334900
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43732049
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41924049
6RUNX_20019798_ChIP-Seq_JUKART_Human2.29442243
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.29251460
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21348139
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.16177553
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13212702
11GBX2_23144817_ChIP-Seq_PC3_Human2.09518379
12ZNF274_21170338_ChIP-Seq_K562_Hela2.05401068
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94796381
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.92218390
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90653098
16EZH2_22144423_ChIP-Seq_EOC_Human1.89917731
17VDR_22108803_ChIP-Seq_LS180_Human1.88076696
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.84560891
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.80448078
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79574337
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74741743
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74049256
23MYB_26560356_Chip-Seq_TH2_Human1.71690173
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.67603952
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67078760
26GATA3_26560356_Chip-Seq_TH2_Human1.66862965
27DROSHA_22980978_ChIP-Seq_HELA_Human1.66459805
28SCL_19346495_ChIP-Seq_HPC-7_Human1.55565553
29VDR_24787735_ChIP-Seq_THP-1_Human1.51736943
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49293211
31GATA3_27048872_Chip-Seq_THYMUS_Human1.48650139
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47899359
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46938472
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.45714929
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44607932
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44508023
37* BCAT_22108803_ChIP-Seq_LS180_Human1.43485551
38AR_21572438_ChIP-Seq_LNCaP_Human1.43036961
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42360633
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39920362
41STAT3_23295773_ChIP-Seq_U87_Human1.37879833
42ER_23166858_ChIP-Seq_MCF-7_Human1.37666444
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37399816
44TAF15_26573619_Chip-Seq_HEK293_Human1.36912526
45IGF1R_20145208_ChIP-Seq_DFB_Human1.36630297
46MYB_26560356_Chip-Seq_TH1_Human1.36584729
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36357990
48* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31910472
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30370164
50TCF4_23295773_ChIP-Seq_U87_Human1.26335194
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24532909
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21772638
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.20447070
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20363348
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18639182
56P300_19829295_ChIP-Seq_ESCs_Human1.18111272
57* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18014553
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17927674
59SMRT_27268052_Chip-Seq_Bcells_Human1.14521982
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12757198
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12757198
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.12396842
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.11702852
64EWS_26573619_Chip-Seq_HEK293_Human1.11240182
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10597707
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10372812
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09892275
68SMAD4_21799915_ChIP-Seq_A2780_Human1.09882675
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09587510
70CBP_20019798_ChIP-Seq_JUKART_Human1.08038597
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08038597
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07917821
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06689955
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05658007
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05291637
76TCF4_22108803_ChIP-Seq_LS180_Human1.04846782
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.04201688
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.03287659
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02770997
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02068061
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.01914890
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00777481
83GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00073832
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99539976
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99198924
86OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98850726
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98496014
88AR_25329375_ChIP-Seq_VCAP_Human0.98398530
89RUNX2_22187159_ChIP-Seq_PCA_Human0.97583216
90AHR_22903824_ChIP-Seq_MCF-7_Human0.97458023
91NANOG_19829295_ChIP-Seq_ESCs_Human0.97094532
92SOX2_19829295_ChIP-Seq_ESCs_Human0.97094532
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.95551541
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93915678
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93122351
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91925713
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91684117
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.91684117
99GATA1_22025678_ChIP-Seq_K562_Human0.91655644
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91194715

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation4.75031145
2MP0002132_abnormal_respiratory_system4.05998953
3MP0005671_abnormal_response_to3.69624041
4MP0001800_abnormal_humoral_immune3.30682432
5MP0003763_abnormal_thymus_physiology3.04476651
6MP0001835_abnormal_antigen_presentation2.95534745
7MP0001873_stomach_inflammation2.88906167
8MP0005000_abnormal_immune_tolerance2.48162858
9MP0000685_abnormal_immune_system2.38296083
10MP0003724_increased_susceptibility_to2.37656656
11MP0005387_immune_system_phenotype2.35991243
12MP0001790_abnormal_immune_system2.35991243
13MP0002723_abnormal_immune_serum2.31375849
14MP0002452_abnormal_antigen_presenting2.22331416
15MP0000569_abnormal_digit_pigmentation2.21443558
16MP0002405_respiratory_system_inflammati2.21165240
17MP0003646_muscle_fatigue2.19250436
18MP0009785_altered_susceptibility_to2.09593861
19MP0002420_abnormal_adaptive_immunity2.09117512
20MP0001819_abnormal_immune_cell2.06235842
21MP0010155_abnormal_intestine_physiology2.01826424
22MP0005025_abnormal_response_to1.93066138
23MP0008057_abnormal_DNA_replication1.84311523
24MP0003195_calcinosis1.84303592
25MP0002138_abnormal_hepatobiliary_system1.81834910
26MP0003045_fibrosis1.81397029
27MP0002419_abnormal_innate_immunity1.73468223
28MP0003436_decreased_susceptibility_to1.69338960
29MP0005167_abnormal_blood-brain_barrier1.69108383
30MP0000716_abnormal_immune_system1.68097751
31MP0002398_abnormal_bone_marrow1.65366890
32MP0005310_abnormal_salivary_gland1.62004742
33MP0003252_abnormal_bile_duct1.50596404
34MP0000689_abnormal_spleen_morphology1.50185013
35MP0001501_abnormal_sleep_pattern1.47792857
36MP0002148_abnormal_hypersensitivity_rea1.47517944
37MP0003300_gastrointestinal_ulcer1.44376129
38MP0002928_abnormal_bile_duct1.42481968
39MP0001845_abnormal_inflammatory_respons1.42364819
40MP0004142_abnormal_muscle_tone1.40877201
41MP0009764_decreased_sensitivity_to1.33853573
42MP0001986_abnormal_taste_sensitivity1.33850913
43MP0003866_abnormal_defecation1.30168094
44MP0002722_abnormal_immune_system1.29572101
45MP0005075_abnormal_melanosome_morpholog1.28336469
46MP0005645_abnormal_hypothalamus_physiol1.27669440
47MP0000858_altered_metastatic_potential1.26727117
48MP0008961_abnormal_basal_metabolism1.24239812
49MP0009333_abnormal_splenocyte_physiolog1.23098237
50MP0004883_abnormal_blood_vessel1.18636519
51MP0000703_abnormal_thymus_morphology1.18168366
52MP0003303_peritoneal_inflammation1.17759645
53MP0001663_abnormal_digestive_system1.17564592
54MP0002429_abnormal_blood_cell1.16005152
55MP0005408_hypopigmentation1.15092303
56MP0004130_abnormal_muscle_cell1.13645973
57MP0008469_abnormal_protein_level1.12807264
58MP0004381_abnormal_hair_follicle1.10985359
59MP0001968_abnormal_touch/_nociception1.08401044
60MP0005464_abnormal_platelet_physiology1.06785260
61MP0003183_abnormal_peptide_metabolism1.05043003
62MP0004043_abnormal_pH_regulation1.03543949
63MP0008872_abnormal_physiological_respon0.97820328
64MP0002933_joint_inflammation0.95868355
65MP0008877_abnormal_DNA_methylation0.92863575
66MP0002166_altered_tumor_susceptibility0.90890383
67MP0002693_abnormal_pancreas_physiology0.89984303
68MP0003787_abnormal_imprinting0.89314794
69MP0005551_abnormal_eye_electrophysiolog0.89072756
70MP0002837_dystrophic_cardiac_calcinosis0.85179936
71MP0009697_abnormal_copulation0.84122266
72MP0000230_abnormal_systemic_arterial0.83872508
73MP0004145_abnormal_muscle_electrophysio0.82395537
74MP0002736_abnormal_nociception_after0.82037801
75MP0005647_abnormal_sex_gland0.81350408
76MP0000427_abnormal_hair_cycle0.78510727
77MP0003828_pulmonary_edema0.78357207
78MP0003690_abnormal_glial_cell0.76473353
79MP0000372_irregular_coat_pigmentation0.75288489
80MP0009745_abnormal_behavioral_response0.74517710
81MP0000470_abnormal_stomach_morphology0.74397966
82MP0009046_muscle_twitch0.73575045
83MP0000249_abnormal_blood_vessel0.70831477
84MP0003633_abnormal_nervous_system0.70708686
85MP0002168_other_aberrant_phenotype0.70614189
86MP0001533_abnormal_skeleton_physiology0.68638065
87MP0000465_gastrointestinal_hemorrhage0.68341262
88MP0005174_abnormal_tail_pigmentation0.67908854
89MP0005397_hematopoietic_system_phenotyp0.67687251
90MP0001545_abnormal_hematopoietic_system0.67687251
91MP0004084_abnormal_cardiac_muscle0.67135464
92MP0002277_abnormal_respiratory_mucosa0.66618268
93MP0002009_preneoplasia0.65701708
94MP0004036_abnormal_muscle_relaxation0.63345064
95MP0004947_skin_inflammation0.61740903
96MP0005381_digestive/alimentary_phenotyp0.61659158
97MP0002396_abnormal_hematopoietic_system0.61652718
98MP0005266_abnormal_metabolism0.60010494
99MP0002136_abnormal_kidney_physiology0.59207474
100MP0005085_abnormal_gallbladder_physiolo0.56770285

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)4.70122875
2Elevated erythrocyte sedimentation rate (HP:0003565)4.54446009
3Myositis (HP:0100614)4.11241711
4Abnormality of T cell physiology (HP:0011840)3.94528519
5Genetic anticipation (HP:0003743)3.94477401
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.80148765
7Abnormality of the nasal mucosa (HP:0000433)3.75308923
8Abnormality of T cells (HP:0002843)3.69114155
9Stomach cancer (HP:0012126)3.41068852
10Abnormality of T cell number (HP:0011839)3.38706856
11Abnormality of pyrimidine metabolism (HP:0004353)3.36980243
12Panhypogammaglobulinemia (HP:0003139)3.13915784
13T lymphocytopenia (HP:0005403)3.12759993
14Encephalitis (HP:0002383)3.08114862
15Attenuation of retinal blood vessels (HP:0007843)3.05197147
16Recurrent fungal infections (HP:0002841)3.04749251
17Progressive cerebellar ataxia (HP:0002073)3.01432707
18Stomatitis (HP:0010280)3.00817614
19Agammaglobulinemia (HP:0004432)3.00755826
20Pancreatic cysts (HP:0001737)2.98141887
21Hyperventilation (HP:0002883)2.97323538
22Hemiplegia (HP:0002301)2.94460676
23Retrobulbar optic neuritis (HP:0100654)2.90679532
24Optic neuritis (HP:0100653)2.90679532
25Recurrent cutaneous fungal infections (HP:0011370)2.87853050
26Chronic mucocutaneous candidiasis (HP:0002728)2.87853050
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87401279
28Gaze-evoked nystagmus (HP:0000640)2.86725778
29Clumsiness (HP:0002312)2.81173851
30Fair hair (HP:0002286)2.81155069
31Zonular cataract (HP:0010920)2.80494076
32Recurrent bacterial skin infections (HP:0005406)2.80001337
33Meningitis (HP:0001287)2.78440751
34Pustule (HP:0200039)2.78324209
35Congenital stationary night blindness (HP:0007642)2.78143879
36Protruding tongue (HP:0010808)2.70539418
37Recurrent bronchitis (HP:0002837)2.61215564
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.59721028
39IgG deficiency (HP:0004315)2.55881895
40Chronic diarrhea (HP:0002028)2.55376161
41Vasculitis (HP:0002633)2.54273883
42Orchitis (HP:0100796)2.52046221
43Inability to walk (HP:0002540)2.47452492
44Recurrent abscess formation (HP:0002722)2.42893776
45Autoimmune hemolytic anemia (HP:0001890)2.41943511
46Facial diplegia (HP:0001349)2.38831054
47Autoimmune thrombocytopenia (HP:0001973)2.35403235
48Recurrent sinusitis (HP:0011108)2.32665949
49True hermaphroditism (HP:0010459)2.32514865
50Abnormality of midbrain morphology (HP:0002418)2.32289785
51Molar tooth sign on MRI (HP:0002419)2.32289785
52Generalized hypopigmentation of hair (HP:0011358)2.28426988
53Pancreatic fibrosis (HP:0100732)2.28320071
54Progressive inability to walk (HP:0002505)2.24959399
55Keratoconjunctivitis (HP:0001096)2.24350218
56Thrombocytosis (HP:0001894)2.23337429
57Recurrent skin infections (HP:0001581)2.21642729
58Poikilocytosis (HP:0004447)2.20634683
59Hypoproteinemia (HP:0003075)2.20593055
60Mediastinal lymphadenopathy (HP:0100721)2.20363444
61Abnormality of the renal cortex (HP:0011035)2.17249054
62Hemoptysis (HP:0002105)2.16888137
63Pulmonary infiltrates (HP:0002113)2.15489390
64Thyroiditis (HP:0100646)2.14605236
65Recurrent viral infections (HP:0004429)2.13568617
66Decreased circulating renin level (HP:0003351)2.13529502
67Keratoconjunctivitis sicca (HP:0001097)2.13449655
68Severe combined immunodeficiency (HP:0004430)2.12620912
69Lymphopenia (HP:0001888)2.09298865
70Hypsarrhythmia (HP:0002521)2.08496115
71Abnormality of B cell number (HP:0010975)2.07979159
72Inflammation of the large intestine (HP:0002037)2.07073831
73Increased cerebral lipofuscin (HP:0011813)2.06936099
74Abnormality of binocular vision (HP:0011514)2.04831937
75Diplopia (HP:0000651)2.04831937
76Abolished electroretinogram (ERG) (HP:0000550)2.02898174
77Abnormality of eosinophils (HP:0001879)2.02896979
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.02480457
79Abnormality of monocarboxylic acid metabolism (HP:0010996)2.02177359
80Abnormality of macrophages (HP:0004311)2.01705226
81EEG with generalized epileptiform discharges (HP:0011198)2.01231562
82Eczematoid dermatitis (HP:0000976)1.99931668
83Chest pain (HP:0100749)1.99137153
84Epileptiform EEG discharges (HP:0011182)1.98801821
85Gastrointestinal stroma tumor (HP:0100723)1.96191234
86Colitis (HP:0002583)1.93690630
87Chronic hepatic failure (HP:0100626)1.91144376
88Febrile seizures (HP:0002373)1.90664303
89Prolonged bleeding time (HP:0003010)1.89776072
90Chronic otitis media (HP:0000389)1.89120379
91Leukocytosis (HP:0001974)1.88946068
92Nephronophthisis (HP:0000090)1.88876671
93Eosinophilia (HP:0001880)1.88507631
94IgM deficiency (HP:0002850)1.87449321
95Abnormality of the renal medulla (HP:0100957)1.87400778
96Congenital sensorineural hearing impairment (HP:0008527)1.86362200
97Abnormality of the prostate (HP:0008775)1.85199627
98Hypochromic anemia (HP:0001931)1.84951897
99Bony spicule pigmentary retinopathy (HP:0007737)1.83541349
100Gastrointestinal inflammation (HP:0004386)1.81934049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.19836234
2ITK3.80938834
3MAP4K13.28577059
4TXK2.79283997
5PTK2B2.72214396
6ACVR1B2.57562622
7ZAP702.55074990
8TAOK32.31847285
9BLK2.10888147
10RIPK41.99442921
11BTK1.99404500
12SYK1.93140810
13INSRR1.88558880
14ADRBK21.84835054
15TEC1.74786627
16BMPR1B1.70053534
17MAP3K71.69177775
18TNK21.49868012
19FES1.45921185
20MAPK71.36621556
21TBK11.25727722
22GRK11.24494452
23PIK3CG1.23770157
24JAK11.22879432
25JAK31.21690793
26IKBKE1.19648357
27KIT1.17311017
28IKBKB1.16410748
29TYK21.16113654
30LYN1.12658567
31HCK1.10305129
32MAPK131.10071757
33SIK21.09743279
34PIM11.09677678
35CSK1.09328352
36LCK1.08551571
37IRAK41.02813878
38STK390.99110370
39CDK40.95598017
40MAP3K140.92835546
41CAMKK20.92032342
42WNK40.90882057
43PRKCQ0.90431263
44GRK60.89396366
45BMPR20.86020863
46MARK30.84838958
47ADRBK10.84409878
48NLK0.84384081
49CSF1R0.83922454
50TRPM70.81970753
51OXSR10.80887588
52IRAK10.78932662
53PRKAA20.76079473
54NUAK10.71241117
55CHUK0.68930885
56PIK3CA0.67943663
57PRKG20.65640822
58MELK0.65246862
59MAP4K20.65135175
60WNK30.64268047
61MAP3K130.64098834
62HIPK20.60260503
63TGFBR10.60228635
64SGK20.60029012
65JAK20.59607368
66PDGFRB0.58718657
67PDK10.57464599
68STK380.57126410
69MAP2K60.56619506
70CDC42BPA0.54693159
71GRK70.53460926
72PRKCZ0.53071598
73CAMKK10.52950911
74MAPK110.52809470
75GSK3A0.52646626
76AKT30.52517664
77PKN10.51845150
78ZAK0.51084328
79PRKCH0.50718406
80FGFR30.48447953
81DAPK20.46853935
82OBSCN0.45892366
83MKNK20.45266232
84CHEK20.45169164
85TLK10.44916124
86WNK10.43244840
87STK110.41984779
88TGFBR20.39251868
89RPS6KA60.36043673
90CAMK40.35203475
91PRKCE0.35079377
92FYN0.34118105
93NTRK30.32945234
94MATK0.31581438
95MAPK120.31403588
96PRKAA10.31219308
97CSNK1A10.29632500
98IGF1R0.28209653
99BRD40.27575945
100CAMK10.27385935

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.70866023
2Allograft rejection_Homo sapiens_hsa053303.14779829
3Autoimmune thyroid disease_Homo sapiens_hsa053203.00368794
4Primary immunodeficiency_Homo sapiens_hsa053402.97545118
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.83519811
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.78031308
7Type I diabetes mellitus_Homo sapiens_hsa049402.49505265
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.40954070
9Asthma_Homo sapiens_hsa053102.38760651
10Staphylococcus aureus infection_Homo sapiens_hsa051502.21285948
11Antigen processing and presentation_Homo sapiens_hsa046122.19583855
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.91900587
13T cell receptor signaling pathway_Homo sapiens_hsa046601.75222915
14Leishmaniasis_Homo sapiens_hsa051401.72112563
15Viral myocarditis_Homo sapiens_hsa054161.61373816
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51961548
17B cell receptor signaling pathway_Homo sapiens_hsa046621.49878693
18Hematopoietic cell lineage_Homo sapiens_hsa046401.44098568
19Osteoclast differentiation_Homo sapiens_hsa043801.35349395
20ABC transporters_Homo sapiens_hsa020101.34005000
21Linoleic acid metabolism_Homo sapiens_hsa005911.32453210
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30445780
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22056247
24Measles_Homo sapiens_hsa051621.17578011
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17170981
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15762818
27Phototransduction_Homo sapiens_hsa047441.12879190
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.08566605
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08372463
30Rheumatoid arthritis_Homo sapiens_hsa053231.06238887
31Toxoplasmosis_Homo sapiens_hsa051451.04222015
32Malaria_Homo sapiens_hsa051441.02021408
33Tuberculosis_Homo sapiens_hsa051520.99260791
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98722379
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97518763
36Platelet activation_Homo sapiens_hsa046110.97298297
37TNF signaling pathway_Homo sapiens_hsa046680.96176887
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.94868184
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92462117
40Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91864644
41Herpes simplex infection_Homo sapiens_hsa051680.91012983
42Ether lipid metabolism_Homo sapiens_hsa005650.90957739
43Chemokine signaling pathway_Homo sapiens_hsa040620.85949396
44Glycerolipid metabolism_Homo sapiens_hsa005610.84613477
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84358028
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84084245
47Taste transduction_Homo sapiens_hsa047420.83836873
48Olfactory transduction_Homo sapiens_hsa047400.83340376
49Influenza A_Homo sapiens_hsa051640.81646628
50Morphine addiction_Homo sapiens_hsa050320.79759127
51Nitrogen metabolism_Homo sapiens_hsa009100.78396698
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76590433
53African trypanosomiasis_Homo sapiens_hsa051430.74756930
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.74078274
55Calcium signaling pathway_Homo sapiens_hsa040200.72705717
56Dorso-ventral axis formation_Homo sapiens_hsa043200.72679860
57Ovarian steroidogenesis_Homo sapiens_hsa049130.71880965
58Nicotine addiction_Homo sapiens_hsa050330.69443325
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67392996
60Butanoate metabolism_Homo sapiens_hsa006500.66434080
61Choline metabolism in cancer_Homo sapiens_hsa052310.64938993
62Tryptophan metabolism_Homo sapiens_hsa003800.64727630
63Type II diabetes mellitus_Homo sapiens_hsa049300.63074251
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61840573
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60873399
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59571781
67Serotonergic synapse_Homo sapiens_hsa047260.56854328
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.56452067
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56444072
70Oxytocin signaling pathway_Homo sapiens_hsa049210.54660173
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.54090220
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.53781521
73Insulin resistance_Homo sapiens_hsa049310.53178446
74MAPK signaling pathway_Homo sapiens_hsa040100.52574008
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50451981
76Salivary secretion_Homo sapiens_hsa049700.50414615
77Arachidonic acid metabolism_Homo sapiens_hsa005900.49088389
78Cholinergic synapse_Homo sapiens_hsa047250.48841588
79Circadian entrainment_Homo sapiens_hsa047130.48272277
80Epstein-Barr virus infection_Homo sapiens_hsa051690.47282968
81Caffeine metabolism_Homo sapiens_hsa002320.45648991
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44159909
83FoxO signaling pathway_Homo sapiens_hsa040680.43379658
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43040797
85Selenocompound metabolism_Homo sapiens_hsa004500.41164071
86Prolactin signaling pathway_Homo sapiens_hsa049170.39575526
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39342290
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38504683
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38158353
90RNA degradation_Homo sapiens_hsa030180.37319447
91Glutamatergic synapse_Homo sapiens_hsa047240.37033897
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.36505324
93Hepatitis B_Homo sapiens_hsa051610.36063272
94Ras signaling pathway_Homo sapiens_hsa040140.35439458
95Acute myeloid leukemia_Homo sapiens_hsa052210.35357095
96Chemical carcinogenesis_Homo sapiens_hsa052040.33099883
97Hepatitis C_Homo sapiens_hsa051600.32758317
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32048181
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.31711184
100VEGF signaling pathway_Homo sapiens_hsa043700.31284999

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