PARP16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.96037436
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.86556296
3L-phenylalanine catabolic process (GO:0006559)6.86556296
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.65497718
5L-phenylalanine metabolic process (GO:0006558)6.65497718
6regulation of meiosis I (GO:0060631)6.24608975
7aromatic amino acid family catabolic process (GO:0009074)5.92628496
8cysteine metabolic process (GO:0006534)5.52764864
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50278149
10glyoxylate metabolic process (GO:0046487)5.22633340
11sulfur amino acid catabolic process (GO:0000098)5.21654998
12indole-containing compound catabolic process (GO:0042436)5.13830495
13indolalkylamine catabolic process (GO:0046218)5.13830495
14tryptophan catabolic process (GO:0006569)5.13830495
15kynurenine metabolic process (GO:0070189)5.11240152
16bile acid biosynthetic process (GO:0006699)5.03934281
17alpha-linolenic acid metabolic process (GO:0036109)5.02376483
18regulation of DNA methylation (GO:0044030)4.96032259
19tryptophan metabolic process (GO:0006568)4.92369419
20high-density lipoprotein particle remodeling (GO:0034375)4.91546617
21urea cycle (GO:0000050)4.86785567
22urea metabolic process (GO:0019627)4.86785567
23DNA methylation involved in gamete generation (GO:0043046)4.78057174
24serine family amino acid catabolic process (GO:0009071)4.76142044
25negative regulation of fibrinolysis (GO:0051918)4.72160872
26intestinal cholesterol absorption (GO:0030299)4.71255581
27glycine metabolic process (GO:0006544)4.62985223
28peptidyl-glutamic acid carboxylation (GO:0017187)4.60428309
29protein carboxylation (GO:0018214)4.60428309
30lysine catabolic process (GO:0006554)4.58481990
31lysine metabolic process (GO:0006553)4.58481990
32complement activation, alternative pathway (GO:0006957)4.57302521
33homocysteine metabolic process (GO:0050667)4.56492634
34regulation of protein activation cascade (GO:2000257)4.52545902
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.51046684
36nitrogen cycle metabolic process (GO:0071941)4.50980213
37regulation of fibrinolysis (GO:0051917)4.41554790
38regulation of female gonad development (GO:2000194)4.40704196
39aromatic amino acid family metabolic process (GO:0009072)4.35660941
40bile acid metabolic process (GO:0008206)4.35638737
41amino-acid betaine metabolic process (GO:0006577)4.33501370
42serine family amino acid biosynthetic process (GO:0009070)4.33152060
43serine family amino acid metabolic process (GO:0009069)4.31815691
44reverse cholesterol transport (GO:0043691)4.27630049
45regulation of triglyceride catabolic process (GO:0010896)4.25940193
46regulation of cholesterol esterification (GO:0010872)4.24707742
47meiotic cell cycle (GO:0051321)4.22270747
48regulation of complement activation (GO:0030449)4.22073880
49alpha-amino acid catabolic process (GO:1901606)4.20018832
50triglyceride homeostasis (GO:0070328)4.17769680
51acylglycerol homeostasis (GO:0055090)4.17769680
52valine metabolic process (GO:0006573)4.15815286
53gene silencing by RNA (GO:0031047)4.15775197
54plasma lipoprotein particle remodeling (GO:0034369)4.13286600
55protein-lipid complex remodeling (GO:0034368)4.13286600
56macromolecular complex remodeling (GO:0034367)4.13286600
57tyrosine metabolic process (GO:0006570)4.11177920
58phospholipid efflux (GO:0033700)4.03803253
59metallo-sulfur cluster assembly (GO:0031163)4.01823261
60iron-sulfur cluster assembly (GO:0016226)4.01823261
61cellular modified amino acid catabolic process (GO:0042219)3.97594393
62cellular amino acid catabolic process (GO:0009063)3.95382847
63negative regulation of sterol transport (GO:0032372)3.91566442
64negative regulation of cholesterol transport (GO:0032375)3.91566442
65coenzyme catabolic process (GO:0009109)3.84306510
66bile acid and bile salt transport (GO:0015721)3.82579300
67regulation of B cell receptor signaling pathway (GO:0050855)3.81946680
68plasma lipoprotein particle clearance (GO:0034381)3.81621114
69imidazole-containing compound metabolic process (GO:0052803)3.79840966
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.79193496
71histone H2A acetylation (GO:0043968)3.78969464
72male meiosis I (GO:0007141)3.74229955
73indolalkylamine metabolic process (GO:0006586)3.71338709
74protein kinase C signaling (GO:0070528)3.65389496
75regulation of cholesterol homeostasis (GO:2000188)3.64339340
762-oxoglutarate metabolic process (GO:0006103)3.62621625
77plasma lipoprotein particle assembly (GO:0034377)3.60571297
78ethanol oxidation (GO:0006069)3.60356141
79benzene-containing compound metabolic process (GO:0042537)3.58947138
80cholesterol efflux (GO:0033344)3.56883693
81organic acid catabolic process (GO:0016054)3.55848960
82carboxylic acid catabolic process (GO:0046395)3.55848960
83cellular ketone body metabolic process (GO:0046950)3.52831385
84amine catabolic process (GO:0009310)3.52028394
85cellular biogenic amine catabolic process (GO:0042402)3.52028394
86glutamate metabolic process (GO:0006536)3.51794526
87aldehyde catabolic process (GO:0046185)3.44474763
88fatty acid beta-oxidation (GO:0006635)3.43920695
89cellular glucuronidation (GO:0052695)3.43237218
90fatty acid oxidation (GO:0019395)3.41681806
91positive regulation of triglyceride lipase activity (GO:0061365)3.40885896
92positive regulation of lipoprotein lipase activity (GO:0051006)3.40885896
93regulation of histone H3-K9 methylation (GO:0051570)3.37925176
94L-serine metabolic process (GO:0006563)3.37110201
95monocarboxylic acid catabolic process (GO:0072329)3.36362387
96cholesterol homeostasis (GO:0042632)3.35935741
97short-chain fatty acid metabolic process (GO:0046459)3.35185801
98one-carbon metabolic process (GO:0006730)3.35154606
99fatty acid catabolic process (GO:0009062)3.33421394
100lipid oxidation (GO:0034440)3.32847156
101synapsis (GO:0007129)3.32566780
102phospholipid homeostasis (GO:0055091)3.32563655
103positive regulation of histone H3-K4 methylation (GO:0051571)3.31958366
104branched-chain amino acid catabolic process (GO:0009083)3.31775364
105regulation of acrosome reaction (GO:0060046)3.31315451
106sterol homeostasis (GO:0055092)3.29824590
107aspartate family amino acid catabolic process (GO:0009068)3.29063969
108complement activation, classical pathway (GO:0006958)3.27939956
109multicellular organism reproduction (GO:0032504)3.27912691
110negative regulation of lipase activity (GO:0060192)3.27644851
111sister chromatid cohesion (GO:0007062)3.24892041
112CENP-A containing nucleosome assembly (GO:0034080)3.24201963
113mitotic chromosome condensation (GO:0007076)3.23954504
114blood coagulation, intrinsic pathway (GO:0007597)3.23833188
115arginine metabolic process (GO:0006525)3.23321056
116response to nitrosative stress (GO:0051409)3.23231383
117low-density lipoprotein particle remodeling (GO:0034374)3.23101295
118very-low-density lipoprotein particle assembly (GO:0034379)3.22892960
119branched-chain amino acid metabolic process (GO:0009081)3.22592674
120cofactor catabolic process (GO:0051187)3.22205206
121carnitine metabolic process (GO:0009437)3.21862168
122drug catabolic process (GO:0042737)3.21847460
123meiosis I (GO:0007127)3.15040052
124DNA methylation (GO:0006306)3.14677152
125DNA alkylation (GO:0006305)3.14677152
126synaptonemal complex assembly (GO:0007130)3.14177130
127nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.12930508
128chromatin remodeling at centromere (GO:0031055)3.04047987
129pyrimidine dimer repair (GO:0006290)3.01252660
130telomere maintenance via semi-conservative replication (GO:0032201)3.00800612
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00696975
132meiotic nuclear division (GO:0007126)3.00410990
133chromosome organization involved in meiosis (GO:0070192)2.97823212
134nucleotide-excision repair, DNA gap filling (GO:0006297)2.97050828
135female gamete generation (GO:0007292)2.96676546
136protein localization to chromosome, centromeric region (GO:0071459)2.96619377
137protein localization to kinetochore (GO:0034501)2.95496435
138tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94489691
139RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94489691
140protoporphyrinogen IX biosynthetic process (GO:0006782)2.93600943
141ubiquinone biosynthetic process (GO:0006744)2.92150725
142negative regulation of execution phase of apoptosis (GO:1900118)2.90767479
143positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89468443
144microtubule severing (GO:0051013)2.88442289
145attachment of spindle microtubules to kinetochore (GO:0008608)2.88206070
146spermatid nucleus differentiation (GO:0007289)2.87024768
147positive regulation of humoral immune response (GO:0002922)2.86751773
148pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85033060
149negative regulation of reproductive process (GO:2000242)2.84307760
150base-excision repair, AP site formation (GO:0006285)2.82939962
151retinal cone cell development (GO:0046549)2.82930594
152male meiosis (GO:0007140)2.81351561
153neural tube formation (GO:0001841)2.80191638
154oocyte development (GO:0048599)2.79732821
155resolution of meiotic recombination intermediates (GO:0000712)2.79345090
156protein localization to chromosome (GO:0034502)2.78918095
157prenylation (GO:0097354)2.78296817
158protein prenylation (GO:0018342)2.78296817
159monoubiquitinated protein deubiquitination (GO:0035520)2.78222203
160base-excision repair (GO:0006284)2.75866425
161seminiferous tubule development (GO:0072520)2.72560929
1622-deoxyribonucleotide biosynthetic process (GO:0009265)2.70791237
163deoxyribose phosphate biosynthetic process (GO:0046385)2.70791237
164meiotic cell cycle process (GO:1903046)2.68015909
165binding of sperm to zona pellucida (GO:0007339)2.66950543
166histone H3-K9 demethylation (GO:0033169)2.66849598
167negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.66025883
168negative regulation of cell cycle G2/M phase transition (GO:1902750)2.65124882
169positive regulation of gastrulation (GO:2000543)2.64837869
170synaptonemal complex organization (GO:0070193)2.64472622
171negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.64201050
172telomere maintenance via recombination (GO:0000722)2.63511633
173DNA replication-independent nucleosome assembly (GO:0006336)2.63033285
174DNA replication-independent nucleosome organization (GO:0034724)2.63033285
175centriole replication (GO:0007099)2.62958399
176mitotic recombination (GO:0006312)2.62660552
177histone exchange (GO:0043486)2.60240006
178positive regulation of granulocyte differentiation (GO:0030854)2.59929292
179ubiquinone metabolic process (GO:0006743)2.59678227
180gene silencing (GO:0016458)2.58500911
181GMP metabolic process (GO:0046037)2.57324865
182translesion synthesis (GO:0019985)2.56881562
183pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.55774705
184DNA methylation or demethylation (GO:0044728)2.54451502
185positive regulation of gamma-delta T cell activation (GO:0046645)2.52575939
186viral protein processing (GO:0019082)2.51246775
187DNA replication checkpoint (GO:0000076)2.48903651
188N-terminal protein amino acid acetylation (GO:0006474)2.48088526
189DNA strand elongation involved in DNA replication (GO:0006271)2.46767404
190positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.45447772
191quinone biosynthetic process (GO:1901663)2.43742073
192DNA replication-dependent nucleosome organization (GO:0034723)2.43424762
193DNA replication-dependent nucleosome assembly (GO:0006335)2.43424762
194histone H3-K9 methylation (GO:0051567)2.43285075
195regulation of hypersensitivity (GO:0002883)2.43074205
196regulation of double-strand break repair via homologous recombination (GO:0010569)2.40126105
197gonadal mesoderm development (GO:0007506)2.38665158
198pyrimidine nucleotide catabolic process (GO:0006244)2.37990554
199preassembly of GPI anchor in ER membrane (GO:0016254)2.36443887
200DNA strand elongation (GO:0022616)2.36443035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.28943057
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.50878416
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.80825023
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.02548156
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.86116153
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.61353088
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.51633291
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47278734
9EZH2_22144423_ChIP-Seq_EOC_Human4.21906370
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.08484043
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.45939934
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.31581090
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.83420900
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.69779494
15VDR_23849224_ChIP-Seq_CD4+_Human2.66010533
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.63751027
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41881784
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38482901
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31563482
20* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27623910
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22544136
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09520750
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04960861
24* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04663257
25ZNF274_21170338_ChIP-Seq_K562_Hela2.04233041
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03579188
27GATA1_22025678_ChIP-Seq_K562_Human2.02615024
28* CIITA_25753668_ChIP-Seq_RAJI_Human2.02306677
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.92955980
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92169970
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87760702
32IGF1R_20145208_ChIP-Seq_DFB_Human1.84600908
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84209048
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80486705
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79351446
36IRF1_19129219_ChIP-ChIP_H3396_Human1.79100101
37CLOCK_20551151_ChIP-Seq_293T_Human1.73265921
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.70916355
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67837309
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67324732
41MYB_26560356_Chip-Seq_TH2_Human1.67101802
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66416916
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62899383
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.60915294
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59642399
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58052439
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46960883
48* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45651218
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32039680
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31365279
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30110748
52* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28309818
53SPI1_23547873_ChIP-Seq_NB4_Human1.27721597
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27483486
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27356149
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.27146427
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24822217
58MYB_26560356_Chip-Seq_TH1_Human1.23996777
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21981893
60XRN2_22483619_ChIP-Seq_HELA_Human1.21538671
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21321752
62* TTF2_22483619_ChIP-Seq_HELA_Human1.20964797
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19452187
64GATA3_26560356_Chip-Seq_TH1_Human1.19203053
65MYC_22102868_ChIP-Seq_BL_Human1.19151947
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17683556
67GATA3_27048872_Chip-Seq_THYMUS_Human1.17400812
68MYC_18940864_ChIP-ChIP_HL60_Human1.17194266
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15099034
70* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14267317
71* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12319929
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12168724
73MYC_18555785_ChIP-Seq_MESCs_Mouse1.12049713
74E2F1_17053090_ChIP-ChIP_MCF-7_Human1.10625853
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.10161999
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09527518
77HNF4A_19822575_ChIP-Seq_HepG2_Human1.08925842
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07564701
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07087733
80NANOG_20526341_ChIP-Seq_ESCs_Human1.06645568
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06286240
82RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05175009
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04992123
84E2F7_22180533_ChIP-Seq_HELA_Human1.03709116
85* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03003595
86ELK1_19687146_ChIP-ChIP_HELA_Human1.02388297
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.02094776
88RAC3_21632823_ChIP-Seq_H3396_Human1.01659044
89UTX_26944678_Chip-Seq_JUKART_Human1.00916347
90MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99677386
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98877842
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97976138
93ZNF263_19887448_ChIP-Seq_K562_Human0.96467778
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95956524
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95528295
96JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95509361
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95484215
98LXR_22292898_ChIP-Seq_THP-1_Human0.95462107
99SCL_19346495_ChIP-Seq_HPC-7_Human0.93852123
100E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93728923
101TP53_22573176_ChIP-Seq_HFKS_Human0.93643875
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92679846
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92228342
104* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91598283
105* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90220533
106* GATA4_25053715_ChIP-Seq_YYC3_Human0.88961952
107P300_27268052_Chip-Seq_Bcells_Human0.88955631
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88452719
109PHF8_20622854_ChIP-Seq_HELA_Human0.88286925
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88215118
111* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87835322
112* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87508638
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.87190153
114GATA3_26560356_Chip-Seq_TH2_Human0.87012607
115* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86828896
116MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86478885
117AR_20517297_ChIP-Seq_VCAP_Human0.85556531
118RARB_24833708_ChIP-Seq_LIVER_Mouse0.82889674
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82161509
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82019029
121GATA6_25053715_ChIP-Seq_YYC3_Human0.81290275
122RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80657255
123BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80499621
124KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.80180800
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79370815
126SRF_21415370_ChIP-Seq_HL-1_Mouse0.79217502
127GABP_17652178_ChIP-ChIP_JURKAT_Human0.78606015
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77894994
129* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77313829
130* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76943121
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76897422
132GABP_19822575_ChIP-Seq_HepG2_Human0.76703581
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.76251628
134* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75825625
135THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75132767
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74202095
137AR_21909140_ChIP-Seq_LNCAP_Human0.73779344
138CREB1_15753290_ChIP-ChIP_HEK293T_Human0.73779151
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.72776997
140FOXP3_21729870_ChIP-Seq_TREG_Human0.72734782
141MAF_26560356_Chip-Seq_TH1_Human0.71391896
142HTT_18923047_ChIP-ChIP_STHdh_Human0.71236578
143KDM5A_27292631_Chip-Seq_BREAST_Human0.71118554
144MYC_19030024_ChIP-ChIP_MESCs_Mouse0.70253679
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69653676
146NELFA_20434984_ChIP-Seq_ESCs_Mouse0.69646026
147GATA1_19941826_ChIP-Seq_K562_Human0.69134453
148VDR_21846776_ChIP-Seq_THP-1_Human0.67976577
149DCP1A_22483619_ChIP-Seq_HELA_Human0.67550143
150SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.67541475
151ATF3_27146783_Chip-Seq_COLON_Human0.66808759
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66763412
153MYB_21317192_ChIP-Seq_ERMYB_Mouse0.66109842
154TET1_21451524_ChIP-Seq_MESCs_Mouse0.66082191
155RACK7_27058665_Chip-Seq_MCF-7_Human0.64716556
156ETS1_20019798_ChIP-Seq_JURKAT_Human0.64497809
157TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.63970760
158ELK3_25401928_ChIP-Seq_HUVEC_Human0.63954418
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.63683667
160* NCOR1_26117541_ChIP-Seq_K562_Human0.63508208
161CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.63101048
162* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.62949276
163* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.60678968
164BCOR_27268052_Chip-Seq_Bcells_Human0.60414132
165BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60280068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.97052967
2MP0005360_urolithiasis6.27133337
3MP0005365_abnormal_bile_salt6.11572527
4MP0005085_abnormal_gallbladder_physiolo5.56198668
5MP0008875_abnormal_xenobiotic_pharmacok4.23428532
6MP0003806_abnormal_nucleotide_metabolis3.71258310
7MP0003252_abnormal_bile_duct3.65606740
8MP0005083_abnormal_biliary_tract3.49687373
9MP0001666_abnormal_nutrient_absorption3.29569233
10MP0010329_abnormal_lipoprotein_level3.21402802
11MP0009840_abnormal_foam_cell3.14708612
12MP0006292_abnormal_olfactory_placode3.07041576
13MP0008058_abnormal_DNA_repair3.02999738
14MP0001986_abnormal_taste_sensitivity2.71615151
15MP0003195_calcinosis2.55371935
16MP0005332_abnormal_amino_acid2.54958554
17MP0008789_abnormal_olfactory_epithelium2.50743821
18MP0010094_abnormal_chromosome_stability2.46075525
19MP0005499_abnormal_olfactory_system2.43588544
20MP0005394_taste/olfaction_phenotype2.43588544
21MP0003868_abnormal_feces_composition2.28764606
22MP0003191_abnormal_cellular_cholesterol2.25782211
23MP0003763_abnormal_thymus_physiology2.22902020
24MP0008877_abnormal_DNA_methylation2.22331965
25MP0000609_abnormal_liver_physiology2.21832384
26MP0002118_abnormal_lipid_homeostasis1.99980324
27MP0005220_abnormal_exocrine_pancreas1.99519622
28MP0001929_abnormal_gametogenesis1.92641359
29MP0002138_abnormal_hepatobiliary_system1.90596155
30MP0008260_abnormal_autophagy1.90432329
31MP0005319_abnormal_enzyme/_coenzyme1.88333044
32MP0004019_abnormal_vitamin_homeostasis1.80743379
33MP0003077_abnormal_cell_cycle1.80342036
34MP0005075_abnormal_melanosome_morpholog1.78580585
35MP0003111_abnormal_nucleus_morphology1.75075339
36MP0003183_abnormal_peptide_metabolism1.73356341
37MP0002210_abnormal_sex_determination1.72766027
38MP0001764_abnormal_homeostasis1.69232387
39MP0008995_early_reproductive_senescence1.60190111
40MP0009643_abnormal_urine_homeostasis1.57876546
41MP0002653_abnormal_ependyma_morphology1.52740044
42MP0000653_abnormal_sex_gland1.42089277
43MP0000598_abnormal_liver_morphology1.41306994
44MP0003186_abnormal_redox_activity1.40780069
45MP0002160_abnormal_reproductive_system1.40196775
46MP0003699_abnormal_female_reproductive1.39597446
47MP0004957_abnormal_blastocyst_morpholog1.38770159
48MP0003656_abnormal_erythrocyte_physiolo1.38007347
49MP0002396_abnormal_hematopoietic_system1.37384630
50MP0005584_abnormal_enzyme/coenzyme_acti1.34110765
51MP0003705_abnormal_hypodermis_morpholog1.32896356
52MP0001145_abnormal_male_reproductive1.32356431
53MP0003786_premature_aging1.32149097
54MP0003698_abnormal_male_reproductive1.31434717
55MP0000631_abnormal_neuroendocrine_gland1.27495117
56MP0001873_stomach_inflammation1.25327435
57MP0008057_abnormal_DNA_replication1.23441906
58MP0000703_abnormal_thymus_morphology1.21962801
59MP0008932_abnormal_embryonic_tissue1.21528469
60MP0000015_abnormal_ear_pigmentation1.21486700
61MP0005670_abnormal_white_adipose1.18199288
62MP0002234_abnormal_pharynx_morphology1.17484299
63MP0005084_abnormal_gallbladder_morpholo1.16234045
64MP0002398_abnormal_bone_marrow1.14029284
65MP0002722_abnormal_immune_system1.11894854
66MP0004264_abnormal_extraembryonic_tissu1.11712483
67MP0006036_abnormal_mitochondrial_physio1.11061979
68MP0009278_abnormal_bone_marrow1.09199262
69MP0000049_abnormal_middle_ear1.09094435
70MP0002161_abnormal_fertility/fecundity1.08559620
71MP0001800_abnormal_humoral_immune1.08057951
72MP0005636_abnormal_mineral_homeostasis1.07521440
73MP0002078_abnormal_glucose_homeostasis1.07366436
74MP0009763_increased_sensitivity_to1.06347507
75MP0009697_abnormal_copulation1.05211031
76MP0008469_abnormal_protein_level1.04053096
77MP0002132_abnormal_respiratory_system1.02747742
78MP0005410_abnormal_fertilization1.02443488
79MP0002420_abnormal_adaptive_immunity1.01598591
80MP0005397_hematopoietic_system_phenotyp1.01298996
81MP0001545_abnormal_hematopoietic_system1.01298996
82MP0005647_abnormal_sex_gland0.98231980
83MP0001819_abnormal_immune_cell0.97760047
84MP0009642_abnormal_blood_homeostasis0.95479503
85MP0005389_reproductive_system_phenotype0.95372648
86MP0002019_abnormal_tumor_incidence0.94923702
87MP0001119_abnormal_female_reproductive0.92370862
88MP0001730_embryonic_growth_arrest0.92016479
89MP0002723_abnormal_immune_serum0.91855963
90MP0005671_abnormal_response_to0.91575232
91MP0001944_abnormal_pancreas_morphology0.91279068
92MP0001790_abnormal_immune_system0.90774217
93MP0005387_immune_system_phenotype0.90774217
94MP0000681_abnormal_thyroid_gland0.88268543
95MP0000716_abnormal_immune_system0.87961813
96MP0005334_abnormal_fat_pad0.87296756
97MP0004381_abnormal_hair_follicle0.86804977
98MP0009765_abnormal_xenobiotic_induced0.86141571
99MP0009764_decreased_sensitivity_to0.85715407
100MP0006276_abnormal_autonomic_nervous0.85131015
101MP0002693_abnormal_pancreas_physiology0.83783552
102MP0001835_abnormal_antigen_presentation0.83290306
103MP0004142_abnormal_muscle_tone0.81864073
104MP0009333_abnormal_splenocyte_physiolog0.80987568
105MP0005464_abnormal_platelet_physiology0.80390901
106MP0002928_abnormal_bile_duct0.79072560
107MP0001756_abnormal_urination0.78776832
108MP0005408_hypopigmentation0.78381542
109MP0010386_abnormal_urinary_bladder0.78142687
110MP0005448_abnormal_energy_balance0.77571101
111MP0010352_gastrointestinal_tract_polyps0.77312479
112MP0010368_abnormal_lymphatic_system0.76872511
113MP0005451_abnormal_body_composition0.76592263
114MP0002452_abnormal_antigen_presenting0.76196037
115MP0002095_abnormal_skin_pigmentation0.76128423
116MP0005646_abnormal_pituitary_gland0.75755141
117MP0003011_delayed_dark_adaptation0.75126465
118MP0002429_abnormal_blood_cell0.73804327
119MP0002971_abnormal_brown_adipose0.72726923
120MP0003121_genomic_imprinting0.72232536
121MP0005376_homeostasis/metabolism_phenot0.70818473
122MP0000313_abnormal_cell_death0.70524225
123MP0000604_amyloidosis0.70370581
124MP0004130_abnormal_muscle_cell0.70344197
125MP0000639_abnormal_adrenal_gland0.70135626
126MP0002102_abnormal_ear_morphology0.68301641
127MP0001853_heart_inflammation0.68295040
128MP0002249_abnormal_larynx_morphology0.68215495
129MP0005266_abnormal_metabolism0.66585854
130MP0001661_extended_life_span0.65612862
131MP0002163_abnormal_gland_morphology0.64360007
132MP0003638_abnormal_response/metabolism_0.64163185
133MP0005666_abnormal_adipose_tissue0.63940969
134MP0003300_gastrointestinal_ulcer0.63003879
135MP0009672_abnormal_birth_weight0.63001878
136MP0003959_abnormal_lean_body0.62601898
137MP0008961_abnormal_basal_metabolism0.62461854
138MP0003953_abnormal_hormone_level0.62142114
139MP0003724_increased_susceptibility_to0.61737208
140MP0005535_abnormal_body_temperature0.61618942
141MP0003436_decreased_susceptibility_to0.60437337
142MP0002970_abnormal_white_adipose0.59058371
143MP0000685_abnormal_immune_system0.58982880
144MP0001845_abnormal_inflammatory_respons0.58744248
145MP0002136_abnormal_kidney_physiology0.56840152
146MP0002876_abnormal_thyroid_physiology0.53360389
147MP0008873_increased_physiological_sensi0.52007921
148MP0004147_increased_porphyrin_level0.50687041
149MP0005058_abnormal_lysosome_morphology0.49749420
150MP0006035_abnormal_mitochondrial_morpho0.46139441
151MP0005023_abnormal_wound_healing0.45094415
152MP0002877_abnormal_melanocyte_morpholog0.44936118
153MP0002135_abnormal_kidney_morphology0.44476611
154MP0010155_abnormal_intestine_physiology0.43348061
155MP0009115_abnormal_fat_cell0.42825383
156MP0004782_abnormal_surfactant_physiolog0.40357646
157MP0003693_abnormal_embryo_hatching0.39108834
158MP0005375_adipose_tissue_phenotype0.39061445
159MP0003943_abnormal_hepatobiliary_system0.39040536
160MP0005187_abnormal_penis_morphology0.37574602
161MP0004947_skin_inflammation0.37339592
162MP0005395_other_phenotype0.37226876
163MP0001243_abnormal_dermal_layer0.36520044
164MP0000689_abnormal_spleen_morphology0.36092131
165MP0002837_dystrophic_cardiac_calcinosis0.35593294
166MP0005025_abnormal_response_to0.35519264
167MP0004043_abnormal_pH_regulation0.33213998
168MP0009785_altered_susceptibility_to0.32964621
169MP0002166_altered_tumor_susceptibility0.32812842
170MP0003718_maternal_effect0.32377765
171MP0002269_muscular_atrophy0.31941515

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.91019011
2Abnormality of monocarboxylic acid metabolism (HP:0010996)6.07184635
3Intrahepatic cholestasis (HP:0001406)6.01400269
4Deep venous thrombosis (HP:0002625)5.95044789
5Hypobetalipoproteinemia (HP:0003563)5.48849829
6Xanthomatosis (HP:0000991)5.32714503
7Prolonged partial thromboplastin time (HP:0003645)5.28025469
8Hypoglycemic coma (HP:0001325)4.95519970
9Complement deficiency (HP:0004431)4.56008682
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.53297131
11Hyperlipoproteinemia (HP:0010980)4.50009176
12Ketosis (HP:0001946)4.40635980
13Hyperammonemia (HP:0001987)4.36905931
14Hyperglycinemia (HP:0002154)4.19929621
15Abnormality of the common coagulation pathway (HP:0010990)4.16965183
16Hypolipoproteinemia (HP:0010981)4.07168270
17Chromsome breakage (HP:0040012)4.06804224
18Abnormality of the intrinsic pathway (HP:0010989)4.05460057
19Fat malabsorption (HP:0002630)4.05180248
20Hyperglycinuria (HP:0003108)3.97374650
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.92384159
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.86694515
23Joint hemorrhage (HP:0005261)3.86640987
24Abnormality of serine family amino acid metabolism (HP:0010894)3.82242703
25Abnormality of glycine metabolism (HP:0010895)3.82242703
26B lymphocytopenia (HP:0010976)3.78505703
27Osteomalacia (HP:0002749)3.71860186
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.67808681
29Abnormality of fatty-acid metabolism (HP:0004359)3.63364094
30Abnormality of methionine metabolism (HP:0010901)3.57964302
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.56040819
32Abnormality of pyrimidine metabolism (HP:0004353)3.55555161
33Hypoglycemic seizures (HP:0002173)3.53802135
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.51543259
35Epidermoid cyst (HP:0200040)3.51369737
36Ketoacidosis (HP:0001993)3.48226128
37Hypoalphalipoproteinemia (HP:0003233)3.48134230
38Hyperbilirubinemia (HP:0002904)3.45300194
39Abnormality of B cell number (HP:0010975)3.40696825
40Conjugated hyperbilirubinemia (HP:0002908)3.37217866
41Abnormality of complement system (HP:0005339)3.27382720
42Steatorrhea (HP:0002570)3.21824536
43Abnormality of DNA repair (HP:0003254)3.16948917
44Retinal dysplasia (HP:0007973)3.15113964
45Gout (HP:0001997)3.10490377
46Generalized aminoaciduria (HP:0002909)3.09851577
47Abnormality of nucleobase metabolism (HP:0010932)3.09569932
48Panhypogammaglobulinemia (HP:0003139)3.07540470
49Hyperinsulinemic hypoglycemia (HP:0000825)3.05436268
50Hypoplasia of the uterus (HP:0000013)3.03621318
51Late onset (HP:0003584)3.01861402
52Abnormality of the preputium (HP:0100587)2.98975013
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.98078818
54Premature ovarian failure (HP:0008209)2.97813277
55Delayed CNS myelination (HP:0002188)2.95938583
56Microvesicular hepatic steatosis (HP:0001414)2.94448915
57Hypercholesterolemia (HP:0003124)2.94201230
58Dicarboxylic aciduria (HP:0003215)2.89429302
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.89429302
60Abnormality of serum amino acid levels (HP:0003112)2.88998268
61Abnormality of purine metabolism (HP:0004352)2.86577317
62Reticulocytopenia (HP:0001896)2.77421930
63Metabolic acidosis (HP:0001942)2.74716982
64Hepatocellular carcinoma (HP:0001402)2.74437446
65Combined immunodeficiency (HP:0005387)2.67744767
66Abnormality of the renal collecting system (HP:0004742)2.63613220
67Stomatitis (HP:0010280)2.61012006
68Severe combined immunodeficiency (HP:0004430)2.60154738
69Impulsivity (HP:0100710)2.59613551
70Gonadotropin excess (HP:0000837)2.57007772
71Abnormality of the ileum (HP:0001549)2.55715886
72Myocardial infarction (HP:0001658)2.54825325
73Tubulointerstitial nephritis (HP:0001970)2.53863016
74Hyperglycemia (HP:0003074)2.53049319
75Lethargy (HP:0001254)2.52251794
76Abnormality of chromosome stability (HP:0003220)2.51946143
77Hypophosphatemic rickets (HP:0004912)2.50618163
78Symptomatic seizures (HP:0011145)2.50292857
79Abnormality of the labia minora (HP:0012880)2.49887672
80Meckel diverticulum (HP:0002245)2.49323467
81Absent rod-and cone-mediated responses on ERG (HP:0007688)2.45742853
82Clubbing of toes (HP:0100760)2.44579232
83Facial hemangioma (HP:0000329)2.43800055
84Skin nodule (HP:0200036)2.42787546
85Duplicated collecting system (HP:0000081)2.41898462
86Abnormality of the pancreatic islet cells (HP:0006476)2.40938902
87Abnormality of endocrine pancreas physiology (HP:0012093)2.40938902
88Pancreatitis (HP:0001733)2.37445049
89Cholecystitis (HP:0001082)2.36679805
90Abnormal gallbladder physiology (HP:0012438)2.36679805
91Opisthotonus (HP:0002179)2.33581530
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.32194232
93Hypergonadotropic hypogonadism (HP:0000815)2.29653133
94Systemic lupus erythematosus (HP:0002725)2.29367200
95Myelodysplasia (HP:0002863)2.28420006
96Neutropenia (HP:0001875)2.27545658
97Irritability (HP:0000737)2.23985312
98Spastic diplegia (HP:0001264)2.23493142
99Abnormal gallbladder morphology (HP:0012437)2.21473660
100Medial flaring of the eyebrow (HP:0010747)2.21121143
101Severe visual impairment (HP:0001141)2.20924850
102Abnormality of male internal genitalia (HP:0000022)2.19419879
103Malnutrition (HP:0004395)2.19365798
104Spontaneous abortion (HP:0005268)2.18595747
105IgG deficiency (HP:0004315)2.18224118
106Hypochromic microcytic anemia (HP:0004840)2.17357341
107Small intestinal stenosis (HP:0012848)2.16344393
108Duodenal stenosis (HP:0100867)2.16344393
109Abnormal number of erythroid precursors (HP:0012131)2.16198122
110Brushfield spots (HP:0001088)2.15308272
111Acanthocytosis (HP:0001927)2.13496421
112Abnormality of lateral ventricle (HP:0030047)2.12889000
113Esophageal varix (HP:0002040)2.12532217
114Menorrhagia (HP:0000132)2.12033791
115Poikiloderma (HP:0001029)2.10981354
116Bone marrow hypocellularity (HP:0005528)2.10718925
117Anterior segment dysgenesis (HP:0007700)2.09738875
118Abnormality of transition element cation homeostasis (HP:0011030)2.09086864
119Abnormality of cells of the erythroid lineage (HP:0012130)2.08693030
120Neonatal onset (HP:0003623)2.06113971
121Cholelithiasis (HP:0001081)2.05823895
122Abnormality of the prostate (HP:0008775)2.04213303
123Aplasia/hypoplasia of the uterus (HP:0008684)2.02646599
124Papillary thyroid carcinoma (HP:0002895)2.02434275
125Vomiting (HP:0002013)2.01611873
126Abnormality of iron homeostasis (HP:0011031)2.00954946
127Poikilocytosis (HP:0004447)2.00568293
128Glomerulonephritis (HP:0000099)2.00019667
129Cerebral edema (HP:0002181)1.99617933
130Horseshoe kidney (HP:0000085)1.96802041
131Abnormal protein glycosylation (HP:0012346)1.96700034
132Abnormal glycosylation (HP:0012345)1.96700034
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96700034
134Abnormal protein N-linked glycosylation (HP:0012347)1.96700034
135Absent thumb (HP:0009777)1.96685552
136Elevated hepatic transaminases (HP:0002910)1.95745375
137Hemorrhage of the eye (HP:0011885)1.95277079
138Type I transferrin isoform profile (HP:0003642)1.93999761
139Encephalitis (HP:0002383)1.93816268
140Renal cortical cysts (HP:0000803)1.93667983
141Nausea (HP:0002018)1.93513458
142Enlarged kidneys (HP:0000105)1.91729577
143Sensorimotor neuropathy (HP:0007141)1.90486379
144Loss of speech (HP:0002371)1.90124697
145Pancytopenia (HP:0001876)1.90074407
146Gingival bleeding (HP:0000225)1.88584931
147Vascular calcification (HP:0004934)1.88086631
148Capillary hemangiomas (HP:0005306)1.87500646
149Insulin resistance (HP:0000855)1.87494296
150Thrombophlebitis (HP:0004418)1.87102595
151Increased purine levels (HP:0004368)1.85857222
152Hyperuricemia (HP:0002149)1.85857222
153Lymphopenia (HP:0001888)1.85276129
154Azoospermia (HP:0000027)1.85249266
155Limb hypertonia (HP:0002509)1.85113826
156Mitral stenosis (HP:0001718)1.84970654
157Proximal tubulopathy (HP:0000114)1.84791309
158Abnormality of the gallbladder (HP:0005264)1.84742148
159Agammaglobulinemia (HP:0004432)1.84468743
160Abnormal cartilage morphology (HP:0002763)1.83153984
161Abnormal enzyme/coenzyme activity (HP:0012379)1.82551730
162Acute hepatic failure (HP:0006554)1.82495220
163Supernumerary spleens (HP:0009799)1.81730454
164Aplasia/Hypoplasia of the thymus (HP:0010515)1.81008505
165Progressive microcephaly (HP:0000253)1.80723082
166Pancreatic islet-cell hyperplasia (HP:0004510)1.80370107
167Abnormal rod and cone electroretinograms (HP:0008323)1.79182695
168Glycosuria (HP:0003076)1.78826028
169Abnormality of urine glucose concentration (HP:0011016)1.78826028
170Elevated erythrocyte sedimentation rate (HP:0003565)1.78435862
171Reduced antithrombin III activity (HP:0001976)1.77680983
172Leukopenia (HP:0001882)1.77381728
173Degeneration of the lateral corticospinal tracts (HP:0002314)1.76157939
174Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76157939
175Oligodactyly (hands) (HP:0001180)1.74794366
176Sloping forehead (HP:0000340)1.73348655
177Attenuation of retinal blood vessels (HP:0007843)1.71939105
178Colon cancer (HP:0003003)1.70283521
179Lissencephaly (HP:0001339)1.69869460
180Male infertility (HP:0003251)1.69167204
181Recurrent fungal infections (HP:0002841)1.69127277
182Pendular nystagmus (HP:0012043)1.67450792
183Heterotopia (HP:0002282)1.67139625
184Neurodegeneration (HP:0002180)1.66489745
185Abnormal spermatogenesis (HP:0008669)1.66386786
186Cleft eyelid (HP:0000625)1.66196791
187Hypoplasia of the thymus (HP:0000778)1.64981467
188Prostate neoplasm (HP:0100787)1.61126937
189Abnormal biliary tract physiology (HP:0012439)1.60703517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.37211521
2ERN14.99055761
3MAP4K24.17816606
4CDK193.98650347
5INSRR3.19442976
6FLT33.06025196
7FGFR42.88046093
8SIK12.78236221
9PKN22.73950197
10TRIB32.63196978
11TRIM282.59333196
12TAOK32.46937599
13MAP3K132.33706081
14MAPK152.30988017
15ZAK2.14856199
16KDR2.06316618
17PNCK2.02782298
18TTK1.98130990
19ARAF1.93806638
20RAF11.85978333
21NUAK11.83294825
22TNK21.80399737
23PIK3CG1.72784411
24MAP3K41.71762578
25MAP3K91.70760224
26EIF2AK31.64033477
27KSR21.63029473
28TYK21.62019019
29FRK1.58712842
30CDK91.56655881
31PTK61.55151029
32BRAF1.54317221
33STK241.50435895
34MAPK111.46490842
35ZAP701.40092405
36AURKA1.39950189
37PASK1.38786459
38MAP2K31.34645779
39IRAK31.32981612
40CDC71.28842704
41MAP4K11.28287735
42CDK81.26294255
43MAP3K101.23542390
44EEF2K1.21908781
45TXK1.21424102
46LATS11.16271460
47MAP2K71.15258301
48RIPK11.15177155
49TGFBR21.15044807
50CSNK1G31.14289681
51DYRK1B1.13793488
52PLK11.10897315
53MAPKAPK31.10174258
54MAP3K111.09230657
55TBK11.08766590
56TESK21.03828798
57BTK0.98813403
58SRPK10.98144111
59TIE10.97870205
60SCYL20.96003210
61TGFBR10.95824416
62MAP2K20.95350574
63CCNB10.95007958
64GRK60.93513669
65JAK20.92603913
66MST1R0.92482139
67CSNK1A1L0.89729933
68EIF2AK10.88842330
69RIPK40.88528846
70CDK40.87588473
71CDK30.86384455
72CDK60.85849063
73SYK0.84227653
74NEK90.82555829
75CSNK1G20.80180260
76BUB10.79710918
77TAOK10.78745172
78RPS6KB20.77467932
79CSNK1G10.76832924
80CAMK1D0.73805311
81PIM20.73478659
82TEC0.73460765
83CAMK1G0.73356338
84MARK30.73007531
85BCR0.71700019
86ACVR1B0.71392180
87ERBB40.71067831
88KSR10.68796299
89IRAK10.67332125
90ITK0.67191123
91IKBKE0.66694232
92EPHA20.66096202
93STK100.65714021
94IRAK20.65516808
95MTOR0.65152872
96STK160.65033339
97NLK0.63291386
98CHEK20.63283748
99MELK0.62798961
100HCK0.62769490
101ATM0.62580608
102JAK30.62480290
103VRK10.61845056
104MAP2K60.60311825
105PIM10.59861980
106CSK0.59627599
107BRSK20.59136894
108LCK0.58855341
109MAP2K40.58564806
110MAP3K30.58486238
111PDGFRA0.58230914
112CHEK10.57731111
113DYRK30.57268663
114PRKAA20.55730776
115MET0.53620657
116TAOK20.53022502
117EPHA30.51617158
118PTK20.51499868
119NEK20.51002400
120KIT0.49007963
121BRSK10.47796818
122LRRK20.46850251
123NME20.46298993
124PLK40.46034424
125CDK20.45905483
126LYN0.45071754
127STK380.44370596
128MAPK40.44248951
129PRKCQ0.44248568
130JAK10.44155086
131ABL20.43504513
132CDK70.43204482
133MAP3K10.43050255
134CSF1R0.42844854
135IRAK40.42559427
136MAP3K70.42514268
137RPS6KA40.42389790
138MAP3K80.42235706
139ICK0.41536075
140PRKAA10.40511554
141VRK20.39709923
142PRKD20.39654082
143STK40.39598709
144CHUK0.38940307
145ERBB20.38591974
146CDK10.36811357
147MAP2K10.36646493
148MAPK70.33281152
149GRK10.32885620
150CDC42BPA0.32369532
151HIPK20.32329675
152IGF1R0.32258314
153MAP3K50.31564105
154MAPK30.30527980
155PINK10.29913560
156BRD40.28703635
157PRKACG0.27145510
158CDK120.25168996
159AURKB0.24095739
160ATR0.23634648

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.01471975
2Mismatch repair_Homo sapiens_hsa034303.59493865
3DNA replication_Homo sapiens_hsa030303.50870892
4Fanconi anemia pathway_Homo sapiens_hsa034603.34048185
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.19849519
6Homologous recombination_Homo sapiens_hsa034403.08794226
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87285957
8Nitrogen metabolism_Homo sapiens_hsa009102.81869984
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.65767899
10Arginine biosynthesis_Homo sapiens_hsa002202.62787769
11Tryptophan metabolism_Homo sapiens_hsa003802.59959983
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59435577
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.57689913
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55958489
15Fatty acid degradation_Homo sapiens_hsa000712.54364631
16Cell cycle_Homo sapiens_hsa041102.54123816
17Nucleotide excision repair_Homo sapiens_hsa034202.38058901
18Complement and coagulation cascades_Homo sapiens_hsa046102.36063015
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.30217423
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22913624
21Basal transcription factors_Homo sapiens_hsa030222.21196739
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20701806
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.16678613
24RNA degradation_Homo sapiens_hsa030182.16087815
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09837065
26Propanoate metabolism_Homo sapiens_hsa006401.99302360
27Selenocompound metabolism_Homo sapiens_hsa004501.98545645
28Peroxisome_Homo sapiens_hsa041461.97426598
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.94072880
30Folate biosynthesis_Homo sapiens_hsa007901.89429072
31Butanoate metabolism_Homo sapiens_hsa006501.88825057
32Oocyte meiosis_Homo sapiens_hsa041141.81075636
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80353191
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79214310
35RNA polymerase_Homo sapiens_hsa030201.78927282
36Fat digestion and absorption_Homo sapiens_hsa049751.76141294
37Histidine metabolism_Homo sapiens_hsa003401.73293581
38Fatty acid metabolism_Homo sapiens_hsa012121.68611435
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68465933
40Caffeine metabolism_Homo sapiens_hsa002321.67664747
41PPAR signaling pathway_Homo sapiens_hsa033201.67185024
42RNA transport_Homo sapiens_hsa030131.65273278
43beta-Alanine metabolism_Homo sapiens_hsa004101.64642129
44Chemical carcinogenesis_Homo sapiens_hsa052041.62787989
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59260868
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57829659
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55642680
48Sulfur metabolism_Homo sapiens_hsa009201.52113982
49Ribosome_Homo sapiens_hsa030101.48177960
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.47950792
51Biosynthesis of amino acids_Homo sapiens_hsa012301.46832013
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45925317
53Staphylococcus aureus infection_Homo sapiens_hsa051501.45513935
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.40776915
55Retinol metabolism_Homo sapiens_hsa008301.39147061
56Starch and sucrose metabolism_Homo sapiens_hsa005001.38324482
57Dorso-ventral axis formation_Homo sapiens_hsa043201.38162033
58Pyruvate metabolism_Homo sapiens_hsa006201.36561937
59Phenylalanine metabolism_Homo sapiens_hsa003601.36094680
60Ovarian steroidogenesis_Homo sapiens_hsa049131.34948254
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.33991249
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30250450
63Carbon metabolism_Homo sapiens_hsa012001.28816681
64Non-homologous end-joining_Homo sapiens_hsa034501.27788528
65Olfactory transduction_Homo sapiens_hsa047401.27383118
66One carbon pool by folate_Homo sapiens_hsa006701.24503788
67Ether lipid metabolism_Homo sapiens_hsa005651.24315532
68ABC transporters_Homo sapiens_hsa020101.23032812
69p53 signaling pathway_Homo sapiens_hsa041151.22422558
70mRNA surveillance pathway_Homo sapiens_hsa030151.19650067
71Tyrosine metabolism_Homo sapiens_hsa003501.19255883
72Spliceosome_Homo sapiens_hsa030401.17837153
73Bile secretion_Homo sapiens_hsa049761.15105570
74T cell receptor signaling pathway_Homo sapiens_hsa046601.14791360
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14688154
76Sulfur relay system_Homo sapiens_hsa041221.13667895
77Purine metabolism_Homo sapiens_hsa002301.04453381
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04353159
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02660655
80Arginine and proline metabolism_Homo sapiens_hsa003301.01046375
81Vitamin digestion and absorption_Homo sapiens_hsa049771.00862370
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98491864
83Glycerolipid metabolism_Homo sapiens_hsa005610.97313003
84Herpes simplex infection_Homo sapiens_hsa051680.96224655
85Lysine degradation_Homo sapiens_hsa003100.95851172
86Fatty acid elongation_Homo sapiens_hsa000620.91573342
87Pentose phosphate pathway_Homo sapiens_hsa000300.88505569
88Vitamin B6 metabolism_Homo sapiens_hsa007500.88018946
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82605800
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82201201
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80264288
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79984115
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79331542
94Steroid biosynthesis_Homo sapiens_hsa001000.74045623
95Phototransduction_Homo sapiens_hsa047440.72701395
96Protein export_Homo sapiens_hsa030600.71334455
97Colorectal cancer_Homo sapiens_hsa052100.71205133
98Galactose metabolism_Homo sapiens_hsa000520.69076988
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68593166
100Glutathione metabolism_Homo sapiens_hsa004800.66571368
101Acute myeloid leukemia_Homo sapiens_hsa052210.65632491
102B cell receptor signaling pathway_Homo sapiens_hsa046620.64367098
103Hepatitis B_Homo sapiens_hsa051610.64028606
104Inositol phosphate metabolism_Homo sapiens_hsa005620.63159707
105Viral carcinogenesis_Homo sapiens_hsa052030.62735296
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60953486
107mTOR signaling pathway_Homo sapiens_hsa041500.60314067
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60064990
109Fructose and mannose metabolism_Homo sapiens_hsa000510.59974259
110Sphingolipid metabolism_Homo sapiens_hsa006000.58903985
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58256819
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56533188
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56216320
114Pancreatic cancer_Homo sapiens_hsa052120.55909588
115Measles_Homo sapiens_hsa051620.55812398
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.54610506
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54064747
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53636109
119Metabolic pathways_Homo sapiens_hsa011000.52541089
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48723546
121HTLV-I infection_Homo sapiens_hsa051660.45721676
122Epstein-Barr virus infection_Homo sapiens_hsa051690.43778478
123Insulin resistance_Homo sapiens_hsa049310.42861350
124Osteoclast differentiation_Homo sapiens_hsa043800.41965070
125Arachidonic acid metabolism_Homo sapiens_hsa005900.38152577
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38020285
127Non-small cell lung cancer_Homo sapiens_hsa052230.35774069
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35744394
129Hematopoietic cell lineage_Homo sapiens_hsa046400.34719769
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34123104
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33405387
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32495214
133Huntingtons disease_Homo sapiens_hsa050160.31110318
134Linoleic acid metabolism_Homo sapiens_hsa005910.30242325
135Prion diseases_Homo sapiens_hsa050200.26573187
136Influenza A_Homo sapiens_hsa051640.26327479
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26149584
138Graft-versus-host disease_Homo sapiens_hsa053320.26080103
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.25475004
140N-Glycan biosynthesis_Homo sapiens_hsa005100.25149796
141Parkinsons disease_Homo sapiens_hsa050120.23686925
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23027991
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.22720345
144Fatty acid biosynthesis_Homo sapiens_hsa000610.20561259
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.18469562
146Glucagon signaling pathway_Homo sapiens_hsa049220.16692037
147Other glycan degradation_Homo sapiens_hsa005110.16654039
148Protein digestion and absorption_Homo sapiens_hsa049740.15611844
149Pancreatic secretion_Homo sapiens_hsa049720.14617202
150AMPK signaling pathway_Homo sapiens_hsa041520.14530423
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.14118784
152Renin-angiotensin system_Homo sapiens_hsa046140.12720258
153Regulation of autophagy_Homo sapiens_hsa041400.11699348
154Pyrimidine metabolism_Homo sapiens_hsa002400.10303721
155Insulin signaling pathway_Homo sapiens_hsa049100.01798551
156Legionellosis_Homo sapiens_hsa051340.01362275
157Bladder cancer_Homo sapiens_hsa05219-0.0820308
158Base excision repair_Homo sapiens_hsa03410-0.0812797
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0709225
160Antigen processing and presentation_Homo sapiens_hsa04612-0.0633314
161Primary immunodeficiency_Homo sapiens_hsa05340-0.0471476
162Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0350782
163Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0329303

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