PARP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA modification (GO:0000154)4.97124615
2rRNA methylation (GO:0031167)4.71106390
3CENP-A containing nucleosome assembly (GO:0034080)4.52811453
4regulation of centriole replication (GO:0046599)4.41199549
5chromatin remodeling at centromere (GO:0031055)4.40927903
6establishment of integrated proviral latency (GO:0075713)4.28680501
7histone exchange (GO:0043486)4.02527714
8DNA replication checkpoint (GO:0000076)4.01338334
9IMP biosynthetic process (GO:0006188)3.94791516
10DNA strand elongation involved in DNA replication (GO:0006271)3.83259216
11DNA strand elongation (GO:0022616)3.73270111
12DNA ligation (GO:0006266)3.67050241
13DNA damage response, detection of DNA damage (GO:0042769)3.65760123
14ribosome assembly (GO:0042255)3.58162428
15DNA replication-dependent nucleosome organization (GO:0034723)3.55005034
16DNA replication-dependent nucleosome assembly (GO:0006335)3.55005034
17telomere maintenance via semi-conservative replication (GO:0032201)3.54956264
18nucleobase biosynthetic process (GO:0046112)3.50723358
19energy coupled proton transport, down electrochemical gradient (GO:0015985)3.49610416
20ATP synthesis coupled proton transport (GO:0015986)3.49610416
21DNA replication-independent nucleosome organization (GO:0034724)3.48978782
22DNA replication-independent nucleosome assembly (GO:0006336)3.48978782
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.48696195
24termination of RNA polymerase III transcription (GO:0006386)3.48696195
25IMP metabolic process (GO:0046040)3.45288855
26mannosylation (GO:0097502)3.44882410
27spliceosomal snRNP assembly (GO:0000387)3.44792901
28chaperone-mediated protein transport (GO:0072321)3.39836606
29proteasome assembly (GO:0043248)3.38863636
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36906000
31purine nucleobase biosynthetic process (GO:0009113)3.35781698
32DNA replication initiation (GO:0006270)3.34628550
33ribosomal small subunit assembly (GO:0000028)3.34486728
34establishment of viral latency (GO:0019043)3.33164316
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28896533
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28880514
37pseudouridine synthesis (GO:0001522)3.27864186
38maternal placenta development (GO:0001893)3.20772540
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18296330
40lysine metabolic process (GO:0006553)3.17302923
41lysine catabolic process (GO:0006554)3.17302923
42DNA catabolic process, exonucleolytic (GO:0000738)3.17278034
43regulation of mitotic spindle checkpoint (GO:1903504)3.16240019
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16240019
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14288366
46preassembly of GPI anchor in ER membrane (GO:0016254)3.13990980
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13364371
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.13364371
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12265643
50negative regulation of ligase activity (GO:0051352)3.12265643
51mitotic sister chromatid segregation (GO:0000070)3.08226582
52protein neddylation (GO:0045116)3.08205373
53GTP biosynthetic process (GO:0006183)3.05645337
54mitochondrial RNA metabolic process (GO:0000959)3.05171555
55folic acid-containing compound biosynthetic process (GO:0009396)3.04303902
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.03502867
57DNA unwinding involved in DNA replication (GO:0006268)3.02986752
58replication fork processing (GO:0031297)3.02739477
59DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98417920
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97779050
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97779050
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97779050
63non-recombinational repair (GO:0000726)2.97231620
64double-strand break repair via nonhomologous end joining (GO:0006303)2.97231620
65establishment of protein localization to mitochondrial membrane (GO:0090151)2.95968431
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94441815
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94441815
68ATP-dependent chromatin remodeling (GO:0043044)2.92441514
69signal transduction involved in DNA damage checkpoint (GO:0072422)2.90791769
70signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90791769
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.88914337
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.88914337
73UTP metabolic process (GO:0046051)2.87707618
74pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.87393085
75transcription-coupled nucleotide-excision repair (GO:0006283)2.84481706
76protein localization to kinetochore (GO:0034501)2.83038416
77pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.82764738
78regulation of cellular amino acid metabolic process (GO:0006521)2.81380669
79biotin metabolic process (GO:0006768)2.81023020
80nucleotide-excision repair, DNA gap filling (GO:0006297)2.80329637
81tRNA aminoacylation for protein translation (GO:0006418)2.79049567
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.78928251
837-methylguanosine mRNA capping (GO:0006370)2.78345646
84UTP biosynthetic process (GO:0006228)2.78263207
85GPI anchor biosynthetic process (GO:0006506)2.77649087
86DNA deamination (GO:0045006)2.76996061
87guanosine-containing compound biosynthetic process (GO:1901070)2.76799609
88tRNA aminoacylation (GO:0043039)2.76423389
89amino acid activation (GO:0043038)2.76423389
90iron-sulfur cluster assembly (GO:0016226)2.76390500
91metallo-sulfur cluster assembly (GO:0031163)2.76390500
92maturation of 5.8S rRNA (GO:0000460)2.75904946
93telomere maintenance via telomere lengthening (GO:0010833)2.75274439
94telomere maintenance via recombination (GO:0000722)2.74726276
95respiratory chain complex IV assembly (GO:0008535)2.74026347
96negative regulation of RNA splicing (GO:0033119)2.72122258
97regulation of helicase activity (GO:0051095)2.71640095
98formation of translation preinitiation complex (GO:0001731)2.71378180
997-methylguanosine RNA capping (GO:0009452)2.70926444
100RNA capping (GO:0036260)2.70926444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.68370537
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.91023388
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.30099292
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82585388
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.81337514
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.76496174
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.67368332
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.22796161
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11401674
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99655317
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.97478168
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.89380733
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.86866330
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.83967716
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62772381
16ELK1_19687146_ChIP-ChIP_HELA_Human2.62567544
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62473394
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53263504
19VDR_23849224_ChIP-Seq_CD4+_Human2.42949873
20FOXP3_21729870_ChIP-Seq_TREG_Human2.40231090
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36308598
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34495874
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27576487
24ZNF274_21170338_ChIP-Seq_K562_Hela2.25827627
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20840819
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14280110
27XRN2_22483619_ChIP-Seq_HELA_Human2.08763042
28YY1_21170310_ChIP-Seq_MESCs_Mouse2.08641723
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.07252083
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.07078302
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.00784638
32TTF2_22483619_ChIP-Seq_HELA_Human1.97409947
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96317160
34MYC_18940864_ChIP-ChIP_HL60_Human1.95607316
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.90517071
36VDR_22108803_ChIP-Seq_LS180_Human1.90356301
37DCP1A_22483619_ChIP-Seq_HELA_Human1.84898222
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84856687
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84666084
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84658502
41EWS_26573619_Chip-Seq_HEK293_Human1.84013498
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83247537
43IGF1R_20145208_ChIP-Seq_DFB_Human1.80457348
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80270857
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.79184694
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79117090
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.70466040
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70246960
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68401700
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66783363
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63785531
52GABP_19822575_ChIP-Seq_HepG2_Human1.63761099
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60238375
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57490890
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56037501
56FUS_26573619_Chip-Seq_HEK293_Human1.51819449
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46892030
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44335590
59AR_21909140_ChIP-Seq_LNCAP_Human1.42279104
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35959271
61TAF15_26573619_Chip-Seq_HEK293_Human1.33493779
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.32843663
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.27056233
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.19146130
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15243967
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13764250
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13439558
68CIITA_25753668_ChIP-Seq_RAJI_Human1.12850599
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11236897
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08707303
71IRF1_19129219_ChIP-ChIP_H3396_Human1.05076667
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.02938958
73KDM5A_27292631_Chip-Seq_BREAST_Human1.02210810
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99462974
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98248296
76TP63_19390658_ChIP-ChIP_HaCaT_Human0.97334368
77ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96084925
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95533599
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94716705
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91088943
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87731533
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87504828
83PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87322700
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83482069
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83272720
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83214372
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79404340
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76818236
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75598035
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75559225
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74441572
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.73828109
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73616737
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72806473
95P300_19829295_ChIP-Seq_ESCs_Human0.70990024
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.67555462
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.67538807
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.67206576
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67203223
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.67070004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.80562116
2MP0008058_abnormal_DNA_repair4.59032064
3MP0003718_maternal_effect3.53022568
4MP0003111_abnormal_nucleus_morphology3.31858666
5MP0003693_abnormal_embryo_hatching3.08842770
6MP0003806_abnormal_nucleotide_metabolis2.94811956
7MP0006292_abnormal_olfactory_placode2.93582570
8MP0002102_abnormal_ear_morphology2.87703875
9MP0004957_abnormal_blastocyst_morpholog2.65248740
10MP0008877_abnormal_DNA_methylation2.55266361
11MP0003077_abnormal_cell_cycle2.40135176
12MP0001293_anophthalmia2.35678767
13MP0002938_white_spotting2.31079836
14MP0000372_irregular_coat_pigmentation2.29234837
15MP0001529_abnormal_vocalization2.20160994
16MP0000566_synostosis2.15769084
17MP0006072_abnormal_retinal_apoptosis2.09746431
18MP0003787_abnormal_imprinting1.86235396
19MP0006035_abnormal_mitochondrial_morpho1.80499639
20MP0008932_abnormal_embryonic_tissue1.80023182
21MP0002277_abnormal_respiratory_mucosa1.76058871
22MP0003786_premature_aging1.73152819
23MP0008057_abnormal_DNA_replication1.69971339
24MP0008007_abnormal_cellular_replicative1.61805852
25MP0006276_abnormal_autonomic_nervous1.60369197
26MP0009697_abnormal_copulation1.53941392
27MP0002160_abnormal_reproductive_system1.42338692
28MP0003121_genomic_imprinting1.41975529
29MP0002234_abnormal_pharynx_morphology1.38938436
30MP0003890_abnormal_embryonic-extraembry1.36161282
31MP0001730_embryonic_growth_arrest1.30657903
32MP0005389_reproductive_system_phenotype1.30651646
33MP0003119_abnormal_digestive_system1.30469245
34MP0005646_abnormal_pituitary_gland1.29736494
35MP0002751_abnormal_autonomic_nervous1.29491645
36MP0005253_abnormal_eye_physiology1.27768491
37MP0003937_abnormal_limbs/digits/tail_de1.24571447
38MP0008789_abnormal_olfactory_epithelium1.23499732
39MP0001929_abnormal_gametogenesis1.20047695
40MP0001919_abnormal_reproductive_system1.19718670
41MP0000579_abnormal_nail_morphology1.18521255
42MP0001145_abnormal_male_reproductive1.14961202
43MP0009672_abnormal_birth_weight1.14605428
44MP0010030_abnormal_orbit_morphology1.12290781
45MP0002210_abnormal_sex_determination1.10835233
46MP0006036_abnormal_mitochondrial_physio1.09227161
47MP0000653_abnormal_sex_gland1.07456755
48MP0008872_abnormal_physiological_respon1.07345427
49MP0005391_vision/eye_phenotype1.07004641
50MP0002837_dystrophic_cardiac_calcinosis1.06762716
51MP0000049_abnormal_middle_ear1.05809609
52MP0009379_abnormal_foot_pigmentation1.05704621
53MP0002163_abnormal_gland_morphology1.05495358
54MP0003195_calcinosis1.04413218
55MP0000350_abnormal_cell_proliferation1.02767564
56MP0002084_abnormal_developmental_patter1.02667033
57MP0002233_abnormal_nose_morphology1.01479349
58MP0003011_delayed_dark_adaptation1.00214086
59MP0003941_abnormal_skin_development1.00098711
60MP0005499_abnormal_olfactory_system0.99647545
61MP0005394_taste/olfaction_phenotype0.99647545
62MP0000313_abnormal_cell_death0.99390311
63MP0002085_abnormal_embryonic_tissue0.99371268
64MP0001485_abnormal_pinna_reflex0.98560421
65MP0001286_abnormal_eye_development0.97871110
66MP0001905_abnormal_dopamine_level0.95773514
67MP0002396_abnormal_hematopoietic_system0.95634755
68MP0002736_abnormal_nociception_after0.95221268
69MP0003315_abnormal_perineum_morphology0.94360777
70MP0003938_abnormal_ear_development0.94313412
71MP0002009_preneoplasia0.92258669
72MP0001697_abnormal_embryo_size0.92178896
73MP0000631_abnormal_neuroendocrine_gland0.90864644
74MP0001661_extended_life_span0.89487877
75MP0000358_abnormal_cell_content/0.88892554
76MP0005395_other_phenotype0.88007267
77MP0003698_abnormal_male_reproductive0.87358012
78MP0000647_abnormal_sebaceous_gland0.87136928
79MP0002111_abnormal_tail_morphology0.85777881
80MP0003283_abnormal_digestive_organ0.85414337
81MP0003137_abnormal_impulse_conducting0.84646119
82MP0001672_abnormal_embryogenesis/_devel0.84472556
83MP0005380_embryogenesis_phenotype0.84472556
84MP0002697_abnormal_eye_size0.84063557
85MP0004197_abnormal_fetal_growth/weight/0.83727809
86MP0004215_abnormal_myocardial_fiber0.83611381
87MP0004142_abnormal_muscle_tone0.81694999
88MP0001764_abnormal_homeostasis0.81451639
89MP0004742_abnormal_vestibular_system0.80980568
90MP0005551_abnormal_eye_electrophysiolog0.80207887
91MP0002092_abnormal_eye_morphology0.79537845
92MP0002080_prenatal_lethality0.79444658
93MP0002282_abnormal_trachea_morphology0.75145695
94MP0001346_abnormal_lacrimal_gland0.73646494
95MP0000537_abnormal_urethra_morphology0.73417378
96MP0004133_heterotaxia0.70969895
97MP0004782_abnormal_surfactant_physiolog0.70644419
98MP0001177_atelectasis0.68189338
99MP0001119_abnormal_female_reproductive0.63772163
100MP0001324_abnormal_eye_pigmentation0.63095706

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.59277043
2Abnormality of the labia minora (HP:0012880)3.54826030
3Acute encephalopathy (HP:0006846)3.45320260
4Abnormal mitochondria in muscle tissue (HP:0008316)3.23669967
5Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19140878
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19140878
7Hyperglycinemia (HP:0002154)3.12005345
8Increased CSF lactate (HP:0002490)3.03374856
9Increased hepatocellular lipid droplets (HP:0006565)3.01779207
10Mitochondrial inheritance (HP:0001427)2.97098597
11Increased serum pyruvate (HP:0003542)2.93053135
12Hyperglycinuria (HP:0003108)2.90368969
13Lipid accumulation in hepatocytes (HP:0006561)2.88619713
14Progressive macrocephaly (HP:0004481)2.83381215
15Hepatocellular necrosis (HP:0001404)2.81328465
16Carpal bone hypoplasia (HP:0001498)2.77107452
17Abnormality of glycolysis (HP:0004366)2.74806445
18Hypothermia (HP:0002045)2.73327363
19Abnormality of glycine metabolism (HP:0010895)2.63761372
20Abnormality of serine family amino acid metabolism (HP:0010894)2.63761372
21Methylmalonic acidemia (HP:0002912)2.60280251
22Abnormal number of erythroid precursors (HP:0012131)2.52765932
23Colon cancer (HP:0003003)2.50881280
24Cerebral edema (HP:0002181)2.45485790
25Type I transferrin isoform profile (HP:0003642)2.45349180
26Patellar aplasia (HP:0006443)2.44915139
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.42947053
28Hepatic necrosis (HP:0002605)2.41497988
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41023979
30Increased serum lactate (HP:0002151)2.38350481
31Aplasia/Hypoplasia of the patella (HP:0006498)2.35085247
32Lactic acidosis (HP:0003128)2.33842643
33Abnormality of the preputium (HP:0100587)2.29277415
34Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27757342
35Abnormality of cells of the erythroid lineage (HP:0012130)2.24620557
36Abnormality of serum amino acid levels (HP:0003112)2.24004573
37Leukodystrophy (HP:0002415)2.23748700
38Reticulocytopenia (HP:0001896)2.23646599
39Cerebral hypomyelination (HP:0006808)2.23387773
40Birth length less than 3rd percentile (HP:0003561)2.22817066
41Gout (HP:0001997)2.18815109
42Meckel diverticulum (HP:0002245)2.18424802
43Nephronophthisis (HP:0000090)2.15730304
44Abnormality of the prostate (HP:0008775)2.14081996
45Pancreatic cysts (HP:0001737)2.13136128
46Limb hypertonia (HP:0002509)2.12596396
47Abnormal protein glycosylation (HP:0012346)2.12285526
48Abnormal glycosylation (HP:0012345)2.12285526
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12285526
50Abnormal protein N-linked glycosylation (HP:0012347)2.12285526
51Lethargy (HP:0001254)2.12144721
52Inability to walk (HP:0002540)2.10319229
53Delayed CNS myelination (HP:0002188)2.10123775
54Increased intramyocellular lipid droplets (HP:0012240)2.08964187
553-Methylglutaconic aciduria (HP:0003535)2.08524833
56Shoulder girdle muscle weakness (HP:0003547)2.06694858
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01992827
58Abnormality of methionine metabolism (HP:0010901)2.00350246
59Pancreatic fibrosis (HP:0100732)1.98897374
60Congenital, generalized hypertrichosis (HP:0004540)1.98823381
61Pendular nystagmus (HP:0012043)1.98439839
62Abnormality of the ileum (HP:0001549)1.98302303
63Renal Fanconi syndrome (HP:0001994)1.97675900
64Methylmalonic aciduria (HP:0012120)1.96580612
65Pancytopenia (HP:0001876)1.95505299
66Small intestinal stenosis (HP:0012848)1.92964294
67Duodenal stenosis (HP:0100867)1.92964294
68Microvesicular hepatic steatosis (HP:0001414)1.91885358
69Abolished electroretinogram (ERG) (HP:0000550)1.91423458
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90744069
71Macrocytic anemia (HP:0001972)1.90552295
72Aplasia of the musculature (HP:0100854)1.90258117
73Abnormal biliary tract physiology (HP:0012439)1.89928108
74Bile duct proliferation (HP:0001408)1.89928108
75Aplastic anemia (HP:0001915)1.89264538
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.88624275
77Stenosis of the external auditory canal (HP:0000402)1.86963023
78Triphalangeal thumb (HP:0001199)1.86832916
79True hermaphroditism (HP:0010459)1.85134069
80Molar tooth sign on MRI (HP:0002419)1.84184380
81Abnormality of midbrain morphology (HP:0002418)1.84184380
82Degeneration of anterior horn cells (HP:0002398)1.82093717
83Abnormality of the anterior horn cell (HP:0006802)1.82093717
84Fibular aplasia (HP:0002990)1.80736636
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79694334
86Abnormality of alanine metabolism (HP:0010916)1.79694334
87Hyperalaninemia (HP:0003348)1.79694334
88Multiple enchondromatosis (HP:0005701)1.79321871
89Epiphyseal stippling (HP:0010655)1.78255857
90Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77788851
91Lissencephaly (HP:0001339)1.77282156
92Optic disc pallor (HP:0000543)1.76112336
93Megaloblastic anemia (HP:0001889)1.75587034
94Horseshoe kidney (HP:0000085)1.75566411
95Chromsome breakage (HP:0040012)1.74270222
96Oral leukoplakia (HP:0002745)1.71585064
97Abnormality of the hip-girdle musculature (HP:0001445)1.71455536
98Abnormality of the musculature of the pelvis (HP:0001469)1.71455536
99Septo-optic dysplasia (HP:0100842)1.70504115
100Sclerocornea (HP:0000647)1.70292639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.95590440
2BUB13.60518446
3VRK23.51914486
4CDC73.31613557
5TRIM282.88429731
6MKNK12.79529433
7PLK42.70817347
8EIF2AK32.70514800
9TSSK62.69525889
10STK162.38073963
11TNIK2.33372296
12TAF12.29614710
13TXK2.29107956
14ZAK2.16087617
15BCKDK2.09711682
16PLK32.06692475
17VRK12.02240541
18NEK11.93120655
19ERBB31.92381636
20MST41.86856369
21MKNK21.84511918
22NUAK11.80172668
23TTK1.75112628
24WNK31.66586602
25PASK1.65789233
26EIF2AK11.65125573
27BMPR1B1.64485955
28TLK11.50735112
29PNCK1.47504628
30PBK1.31042514
31MAP2K71.31024020
32BCR1.28936546
33ATR1.21181354
34PLK11.20474507
35CDK61.12945279
36BRSK21.09235609
37AURKB1.00478344
38KDR0.98941854
39CHEK20.98841012
40MAPKAPK50.96954278
41BRSK10.94694713
42NEK20.92656814
43CSNK1G10.92310479
44CSNK1G30.90983459
45EIF2AK20.90923585
46CDK90.80876372
47OXSR10.80283456
48CCNB10.79606994
49PLK20.77587370
50AURKA0.76526496
51SIK30.76443724
52RPS6KA40.75387106
53CSNK1G20.71083301
54NEK90.70387680
55MAP3K100.70213071
56CDK30.69136628
57DYRK20.67519987
58GRK10.66787212
59ALK0.66171675
60ATM0.61936612
61TGFBR10.61598892
62WEE10.61188904
63CSNK2A10.60089100
64PHKG20.60019795
65PHKG10.60019795
66ADRBK20.58070749
67GRK50.53632620
68RPS6KB20.53265274
69CSNK2A20.52938328
70MAP3K40.52647072
71MINK10.50157124
72RPS6KA50.49937613
73CHEK10.49832315
74CSNK1A1L0.48491098
75SMG10.48387133
76CDK40.48122896
77FRK0.47828916
78LMTK20.43767992
79ERBB40.43020923
80STK390.42811916
81CSNK1E0.40044421
82CDK70.39195381
83DAPK10.38927269
84CDK20.38608774
85CDK10.32990542
86NME10.30314860
87KIT0.29469099
88BRD40.29001496
89TESK20.28291232
90TIE10.28152207
91CDK190.27949046
92PRKCG0.27093925
93CDK180.23772727
94TEC0.23505333
95FGFR20.23188303
96INSRR0.22569575
97PRKDC0.20925445
98PRKACB0.19780567
99MAPK130.19479751
100CSNK1A10.19317448

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.71573508
2Proteasome_Homo sapiens_hsa030503.70096377
3Mismatch repair_Homo sapiens_hsa034303.16921674
4RNA polymerase_Homo sapiens_hsa030203.04711831
5Base excision repair_Homo sapiens_hsa034102.68825764
6Non-homologous end-joining_Homo sapiens_hsa034502.67068165
7Basal transcription factors_Homo sapiens_hsa030222.64561621
8Protein export_Homo sapiens_hsa030602.54025032
9Spliceosome_Homo sapiens_hsa030402.44653248
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44281169
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37811689
12One carbon pool by folate_Homo sapiens_hsa006702.32911906
13Steroid biosynthesis_Homo sapiens_hsa001002.31682014
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27766593
15Ribosome_Homo sapiens_hsa030102.22918231
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21015451
17Homologous recombination_Homo sapiens_hsa034402.16872842
18RNA transport_Homo sapiens_hsa030132.09402813
19Oxidative phosphorylation_Homo sapiens_hsa001902.09034187
20Pyrimidine metabolism_Homo sapiens_hsa002401.97175427
21Parkinsons disease_Homo sapiens_hsa050121.95938189
22Nucleotide excision repair_Homo sapiens_hsa034201.91243408
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.80764596
24Fanconi anemia pathway_Homo sapiens_hsa034601.76313324
25RNA degradation_Homo sapiens_hsa030181.75078444
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66580304
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64468764
28Propanoate metabolism_Homo sapiens_hsa006401.59606141
29Pyruvate metabolism_Homo sapiens_hsa006201.55242522
30Cell cycle_Homo sapiens_hsa041101.52859096
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51516121
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50766722
33Purine metabolism_Homo sapiens_hsa002301.47585763
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44849234
35Sulfur metabolism_Homo sapiens_hsa009201.41817332
36Huntingtons disease_Homo sapiens_hsa050161.37161666
37Fatty acid elongation_Homo sapiens_hsa000621.32705545
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31906472
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24157397
40Biosynthesis of amino acids_Homo sapiens_hsa012301.13053916
41Tryptophan metabolism_Homo sapiens_hsa003801.12932637
42Alzheimers disease_Homo sapiens_hsa050101.08179658
43Selenocompound metabolism_Homo sapiens_hsa004501.07585245
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04621088
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98025639
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94549081
47Carbon metabolism_Homo sapiens_hsa012000.94534219
48Butanoate metabolism_Homo sapiens_hsa006500.90983468
49Phototransduction_Homo sapiens_hsa047440.86835965
50mRNA surveillance pathway_Homo sapiens_hsa030150.86534265
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78336316
52Oocyte meiosis_Homo sapiens_hsa041140.77498031
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.75788201
54Fatty acid degradation_Homo sapiens_hsa000710.71476310
55Peroxisome_Homo sapiens_hsa041460.68080497
56Sulfur relay system_Homo sapiens_hsa041220.66848891
57Metabolic pathways_Homo sapiens_hsa011000.66420646
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65899090
59Vitamin digestion and absorption_Homo sapiens_hsa049770.63191091
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59752021
61p53 signaling pathway_Homo sapiens_hsa041150.58377742
62Hedgehog signaling pathway_Homo sapiens_hsa043400.57975152
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57140720
64Fatty acid metabolism_Homo sapiens_hsa012120.53091150
65Nitrogen metabolism_Homo sapiens_hsa009100.51190837
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50686757
67Arginine and proline metabolism_Homo sapiens_hsa003300.50495197
68Folate biosynthesis_Homo sapiens_hsa007900.48924787
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46677570
70Epstein-Barr virus infection_Homo sapiens_hsa051690.45754317
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43146785
72Basal cell carcinoma_Homo sapiens_hsa052170.42637081
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.40620268
74beta-Alanine metabolism_Homo sapiens_hsa004100.40084685
75Glutathione metabolism_Homo sapiens_hsa004800.38381362
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.34433020
77Fatty acid biosynthesis_Homo sapiens_hsa000610.34223279
78Systemic lupus erythematosus_Homo sapiens_hsa053220.26572624
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25609708
80Cardiac muscle contraction_Homo sapiens_hsa042600.25196403
81Pentose phosphate pathway_Homo sapiens_hsa000300.24403329
82Taste transduction_Homo sapiens_hsa047420.24151411
83Herpes simplex infection_Homo sapiens_hsa051680.22162248
84N-Glycan biosynthesis_Homo sapiens_hsa005100.20039509
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19560636
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18875714
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18485844
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.18384242
89Arginine biosynthesis_Homo sapiens_hsa002200.17752107
90Linoleic acid metabolism_Homo sapiens_hsa005910.16971975
91Glycerolipid metabolism_Homo sapiens_hsa005610.16577366
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.13481916
93Olfactory transduction_Homo sapiens_hsa047400.11154603
94Ether lipid metabolism_Homo sapiens_hsa005650.09862362
95Phenylalanine metabolism_Homo sapiens_hsa003600.08795688
96Wnt signaling pathway_Homo sapiens_hsa043100.08687951
97Primary immunodeficiency_Homo sapiens_hsa053400.08642337
98Hippo signaling pathway_Homo sapiens_hsa043900.06065096
99Arachidonic acid metabolism_Homo sapiens_hsa005900.02827389
100Caffeine metabolism_Homo sapiens_hsa002320.02422892

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »