PARP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.15930244
2DNA strand elongation involved in DNA replication (GO:0006271)4.67861232
3telomere maintenance via semi-conservative replication (GO:0032201)4.59751791
4DNA strand elongation (GO:0022616)4.55573853
5DNA replication initiation (GO:0006270)4.46403947
6telomere maintenance via recombination (GO:0000722)4.28167717
7nucleobase biosynthetic process (GO:0046112)4.13871003
8CENP-A containing nucleosome assembly (GO:0034080)4.13455407
9mitotic recombination (GO:0006312)4.12565922
10purine nucleobase biosynthetic process (GO:0009113)4.11931280
11maturation of SSU-rRNA (GO:0030490)4.11799016
12DNA deamination (GO:0045006)4.06792715
13DNA replication checkpoint (GO:0000076)4.04179662
14chromatin remodeling at centromere (GO:0031055)4.01167135
15DNA unwinding involved in DNA replication (GO:0006268)3.98091904
16telomere maintenance via telomere lengthening (GO:0010833)3.90300012
17kinetochore organization (GO:0051383)3.88153853
18mitotic metaphase plate congression (GO:0007080)3.85748127
19IMP biosynthetic process (GO:0006188)3.78038723
20protein localization to kinetochore (GO:0034501)3.72063436
21kinetochore assembly (GO:0051382)3.65388429
22DNA replication-independent nucleosome assembly (GO:0006336)3.61120580
23DNA replication-independent nucleosome organization (GO:0034724)3.61120580
24formation of translation preinitiation complex (GO:0001731)3.60453348
25DNA double-strand break processing (GO:0000729)3.58664743
26metaphase plate congression (GO:0051310)3.51905577
27nucleotide-excision repair, DNA gap filling (GO:0006297)3.48302089
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.47383786
29establishment of integrated proviral latency (GO:0075713)3.40737553
30establishment of chromosome localization (GO:0051303)3.39253084
31ribosomal large subunit biogenesis (GO:0042273)3.38022051
32mitotic nuclear envelope disassembly (GO:0007077)3.37868990
33microtubule depolymerization (GO:0007019)3.34842730
34ribosome biogenesis (GO:0042254)3.34256637
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.33612824
36telomere maintenance (GO:0000723)3.32706222
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31759060
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31198855
39telomere organization (GO:0032200)3.30637612
40sister chromatid segregation (GO:0000819)3.29583326
41regulation of centriole replication (GO:0046599)3.28471131
42IMP metabolic process (GO:0046040)3.28053918
43meiotic chromosome segregation (GO:0045132)3.27545496
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25894469
45protein localization to chromosome, centromeric region (GO:0071459)3.25673496
46protein K6-linked ubiquitination (GO:0085020)3.25108772
47ribonucleoprotein complex biogenesis (GO:0022613)3.24014468
48attachment of spindle microtubules to kinetochore (GO:0008608)3.21274315
49pseudouridine synthesis (GO:0001522)3.21206599
50viral mRNA export from host cell nucleus (GO:0046784)3.18474790
51histone exchange (GO:0043486)3.17186541
52transcription-coupled nucleotide-excision repair (GO:0006283)3.17117176
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.12497319
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12497319
55cullin deneddylation (GO:0010388)3.10770080
56resolution of meiotic recombination intermediates (GO:0000712)3.09426176
57mismatch repair (GO:0006298)3.08143365
58mitotic chromosome condensation (GO:0007076)3.08060778
59regulation of DNA endoreduplication (GO:0032875)3.07477420
60nuclear envelope disassembly (GO:0051081)3.07144504
61membrane disassembly (GO:0030397)3.07144504
62RNA-dependent DNA replication (GO:0006278)3.06841804
63rRNA processing (GO:0006364)3.06228463
64proteasome assembly (GO:0043248)3.05248520
65regulation of double-strand break repair via homologous recombination (GO:0010569)3.01447640
66viral transcription (GO:0019083)3.01395428
67telomere maintenance via telomerase (GO:0007004)2.98872634
68negative regulation of DNA-dependent DNA replication (GO:2000104)2.97158162
69translational termination (GO:0006415)2.96626568
70nuclear pore organization (GO:0006999)2.96304673
71centriole replication (GO:0007099)2.96027890
72DNA replication-dependent nucleosome organization (GO:0034723)2.95655486
73DNA replication-dependent nucleosome assembly (GO:0006335)2.95655486
74rRNA metabolic process (GO:0016072)2.95561299
75regulation of spindle organization (GO:0090224)2.94973445
76maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94179627
77DNA damage response, detection of DNA damage (GO:0042769)2.93644656
78DNA topological change (GO:0006265)2.93183416
79ribosomal small subunit biogenesis (GO:0042274)2.93171724
80spliceosomal snRNP assembly (GO:0000387)2.92140552
81synapsis (GO:0007129)2.90191024
82regulation of mitochondrial translation (GO:0070129)2.89861273
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88861063
84ribosome assembly (GO:0042255)2.87633938
85nuclear pore complex assembly (GO:0051292)2.87016826
86protein complex biogenesis (GO:0070271)2.86231347
87translational elongation (GO:0006414)2.86155679
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86051276
89protein deneddylation (GO:0000338)2.84336768
90mitotic sister chromatid segregation (GO:0000070)2.84316046
91G1/S transition of mitotic cell cycle (GO:0000082)2.84020344
92cell cycle G1/S phase transition (GO:0044843)2.84020344
93mitochondrial respiratory chain complex assembly (GO:0033108)2.83857242
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83733974
95negative regulation of DNA recombination (GO:0045910)2.81747296
96rRNA modification (GO:0000154)2.81398147
97intra-S DNA damage checkpoint (GO:0031573)2.81281927
98DNA duplex unwinding (GO:0032508)2.80982558
99L-serine metabolic process (GO:0006563)2.80741714
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.79483424
101termination of RNA polymerase III transcription (GO:0006386)2.79483424
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.79431067
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79431067
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79431067
105negative regulation of sister chromatid segregation (GO:0033046)2.79431067
106spindle checkpoint (GO:0031577)2.79146760
107DNA geometric change (GO:0032392)2.78777908
108replication fork processing (GO:0031297)2.77981202
109SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.77232237
110negative regulation of chromosome segregation (GO:0051985)2.77200631
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.76878177
112spindle assembly checkpoint (GO:0071173)2.76560999
113non-recombinational repair (GO:0000726)2.76230213
114double-strand break repair via nonhomologous end joining (GO:0006303)2.76230213
115DNA catabolic process, exonucleolytic (GO:0000738)2.76097480
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75798065
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.75798065
118NADH dehydrogenase complex assembly (GO:0010257)2.75798065
119spliceosomal complex assembly (GO:0000245)2.74880473
120positive regulation of mitochondrial fission (GO:0090141)2.74633543
121mitotic sister chromatid cohesion (GO:0007064)2.73956029
122DNA ligation (GO:0006266)2.73493551
123translational initiation (GO:0006413)2.71053026
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70728615
125regulation of mitotic spindle checkpoint (GO:1903504)2.70728615
126mitotic spindle assembly checkpoint (GO:0007094)2.70312471
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70057596
128regulation of helicase activity (GO:0051095)2.69983020
1297-methylguanosine mRNA capping (GO:0006370)2.69477153
130DNA replication (GO:0006260)2.69269147
131mitotic spindle checkpoint (GO:0071174)2.68612660
132microtubule polymerization or depolymerization (GO:0031109)2.68263223
133histone H2A acetylation (GO:0043968)2.68078182
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.67877599
135maturation of 5.8S rRNA (GO:0000460)2.66786523
136protein-cofactor linkage (GO:0018065)2.65107416
137pyrimidine nucleobase catabolic process (GO:0006208)2.64278343
138establishment of viral latency (GO:0019043)2.61854595
139postreplication repair (GO:0006301)2.59459788
140protein localization to chromosome (GO:0034502)2.59098432
141regulation of chromosome segregation (GO:0051983)2.56704024
142nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56288610
143chromosome segregation (GO:0007059)2.55746830
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53520572
145DNA strand renaturation (GO:0000733)2.49562669
146establishment of protein localization to mitochondrial membrane (GO:0090151)2.46659749
147regulation of centrosome cycle (GO:0046605)2.46355913
148respiratory chain complex IV assembly (GO:0008535)2.44209316
149regulation of mitotic sister chromatid segregation (GO:0033047)2.44005161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.89166909
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.05448845
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.77012000
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.70776596
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48217832
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34032320
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21700477
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.12875493
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.95038919
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92863664
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72149247
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71697673
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.70950542
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62151868
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58946886
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.56644277
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55305298
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54896916
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53901617
20ZNF274_21170338_ChIP-Seq_K562_Hela2.45088639
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44934336
22* VDR_23849224_ChIP-Seq_CD4+_Human2.36376407
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26393365
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22637814
25FOXP3_21729870_ChIP-Seq_TREG_Human2.20275840
26XRN2_22483619_ChIP-Seq_HELA_Human2.17361250
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15333889
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.09358299
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04920122
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00375241
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99914804
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95962591
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95516112
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93771371
35* DCP1A_22483619_ChIP-Seq_HELA_Human1.90890027
36ELK1_19687146_ChIP-ChIP_HELA_Human1.86791427
37IGF1R_20145208_ChIP-Seq_DFB_Human1.86503776
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85079450
39AR_21909140_ChIP-Seq_LNCAP_Human1.80724636
40* TTF2_22483619_ChIP-Seq_HELA_Human1.79758727
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78775121
42GABP_19822575_ChIP-Seq_HepG2_Human1.77085037
43EWS_26573619_Chip-Seq_HEK293_Human1.76033915
44* SRF_21415370_ChIP-Seq_HL-1_Mouse1.75544955
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75151248
46CIITA_25753668_ChIP-Seq_RAJI_Human1.74784223
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.74515516
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72805416
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71605014
50* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70753097
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70152300
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69983039
53FUS_26573619_Chip-Seq_HEK293_Human1.66730309
54TAF15_26573619_Chip-Seq_HEK293_Human1.66561528
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66393489
56* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65804793
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65136923
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.63966173
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59607126
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59042073
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58972276
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56642142
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.52197188
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51883354
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.51290925
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49214480
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47949813
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47208193
69MYC_22102868_ChIP-Seq_BL_Human1.46219936
70GBX2_23144817_ChIP-Seq_PC3_Human1.43904889
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42350299
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41266874
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38405802
74KDM5A_27292631_Chip-Seq_BREAST_Human1.34697538
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31786252
76SPI1_23547873_ChIP-Seq_NB4_Human1.31785627
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31442219
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30343486
79IRF1_19129219_ChIP-ChIP_H3396_Human1.29198047
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.27731453
81VDR_22108803_ChIP-Seq_LS180_Human1.26576149
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25657067
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24596549
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24305133
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.21663731
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21256137
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19885309
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18776684
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17575459
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16740096
91* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15348959
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11880111
93TFEB_21752829_ChIP-Seq_HELA_Human1.11535512
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09843453
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09217606
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09104593
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.09096717
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.08218095
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.06127447
100MYC_18940864_ChIP-ChIP_HL60_Human1.04285541
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02410537
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01281112
103P300_19829295_ChIP-Seq_ESCs_Human0.99913691
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94569648
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93347220
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92374116
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90501681
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90308013
109TP53_22573176_ChIP-Seq_HFKS_Human0.90140881
110RNF2_27304074_Chip-Seq_NSC_Mouse0.90078523
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89930027
112VDR_21846776_ChIP-Seq_THP-1_Human0.89658273
113* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89234545
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88602908
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86971996
116SCL_19346495_ChIP-Seq_HPC-7_Human0.86938387
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86346994
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86122189
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84529035
120SOX9_26525672_Chip-Seq_HEART_Mouse0.83630754
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83493514
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81875778
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.79757818
124KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77662941
125ELK1_22589737_ChIP-Seq_MCF10A_Human0.77587455
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76692291
127FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75980291
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74649306
129* CBP_20019798_ChIP-Seq_JUKART_Human0.74642300
130* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.74642300
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74481835
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.74387196
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74173226
134* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73428218
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73245004
136SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.72321995
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72060775
138MYB_26560356_Chip-Seq_TH1_Human0.71940049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.10026076
2* MP0010094_abnormal_chromosome_stability4.38277507
3MP0008057_abnormal_DNA_replication4.14532619
4MP0003111_abnormal_nucleus_morphology3.97461794
5MP0004957_abnormal_blastocyst_morpholog3.75206820
6* MP0003077_abnormal_cell_cycle3.70418362
7* MP0008058_abnormal_DNA_repair3.55341648
8MP0002396_abnormal_hematopoietic_system3.42996360
9MP0008007_abnormal_cellular_replicative3.03126939
10MP0001529_abnormal_vocalization2.63378121
11MP0003880_abnormal_central_pattern2.50465377
12MP0003123_paternal_imprinting2.49215515
13MP0008932_abnormal_embryonic_tissue2.32004347
14MP0003786_premature_aging2.07300104
15MP0002102_abnormal_ear_morphology2.05537080
16MP0001984_abnormal_olfaction2.00230979
17MP0008877_abnormal_DNA_methylation1.99516137
18MP0000490_abnormal_crypts_of1.98763280
19MP0001835_abnormal_antigen_presentation1.85722905
20MP0008995_early_reproductive_senescence1.85587926
21MP0003122_maternal_imprinting1.83538053
22MP0004808_abnormal_hematopoietic_stem1.83515335
23MP0006276_abnormal_autonomic_nervous1.83481050
24MP0000350_abnormal_cell_proliferation1.71597260
25MP0004859_abnormal_synaptic_plasticity1.71177453
26MP0006292_abnormal_olfactory_placode1.70871162
27MP0005499_abnormal_olfactory_system1.69557584
28MP0005394_taste/olfaction_phenotype1.69557584
29MP0002822_catalepsy1.64724565
30MP0001730_embryonic_growth_arrest1.63480583
31MP0008789_abnormal_olfactory_epithelium1.58783047
32MP0003763_abnormal_thymus_physiology1.58183868
33MP0002398_abnormal_bone_marrow1.57058428
34MP0005075_abnormal_melanosome_morpholog1.55444614
35MP0002132_abnormal_respiratory_system1.55146258
36MP0009333_abnormal_splenocyte_physiolog1.52968084
37MP0004270_analgesia1.51672947
38MP0009046_muscle_twitch1.50536449
39MP0003890_abnormal_embryonic-extraembry1.47655410
40* MP0000313_abnormal_cell_death1.45904258
41MP0006035_abnormal_mitochondrial_morpho1.45744895
42MP0000778_abnormal_nervous_system1.45343925
43MP0003121_genomic_imprinting1.44627075
44MP0005397_hematopoietic_system_phenotyp1.44141085
45MP0001545_abnormal_hematopoietic_system1.44141085
46MP0002019_abnormal_tumor_incidence1.43571880
47MP0002736_abnormal_nociception_after1.42230854
48MP0005671_abnormal_response_to1.42072499
49MP0002234_abnormal_pharynx_morphology1.41364263
50MP0005174_abnormal_tail_pigmentation1.36300069
51MP0000689_abnormal_spleen_morphology1.35351212
52MP0002722_abnormal_immune_system1.34612390
53MP0003186_abnormal_redox_activity1.34219426
54MP0000015_abnormal_ear_pigmentation1.33602976
55MP0001697_abnormal_embryo_size1.29923044
56MP0002638_abnormal_pupillary_reflex1.28891252
57MP0006072_abnormal_retinal_apoptosis1.28507940
58MP0003937_abnormal_limbs/digits/tail_de1.28358803
59MP0005380_embryogenesis_phenotype1.25124195
60MP0001672_abnormal_embryogenesis/_devel1.25124195
61MP0002429_abnormal_blood_cell1.23742418
62MP0010307_abnormal_tumor_latency1.23674648
63MP0000647_abnormal_sebaceous_gland1.23594846
64MP0003567_abnormal_fetal_cardiomyocyte1.23211162
65MP0000703_abnormal_thymus_morphology1.22477145
66MP0009785_altered_susceptibility_to1.22152193
67MP0003787_abnormal_imprinting1.21030651
68MP0000716_abnormal_immune_system1.20463299
69MP0001800_abnormal_humoral_immune1.19754694
70MP0002095_abnormal_skin_pigmentation1.19513489
71MP0002452_abnormal_antigen_presenting1.18196383
72MP0005551_abnormal_eye_electrophysiolog1.17926435
73MP0002080_prenatal_lethality1.17666333
74MP0002420_abnormal_adaptive_immunity1.17482487
75MP0002751_abnormal_autonomic_nervous1.16915774
76MP0001819_abnormal_immune_cell1.16241510
77MP0003718_maternal_effect1.15074447
78MP0002148_abnormal_hypersensitivity_rea1.14463327
79MP0003984_embryonic_growth_retardation1.13754002
80MP0003635_abnormal_synaptic_transmissio1.13686963
81MP0010352_gastrointestinal_tract_polyps1.12527521
82MP0002272_abnormal_nervous_system1.12153720
83MP0005187_abnormal_penis_morphology1.11719234
84MP0002233_abnormal_nose_morphology1.10978311
85MP0000631_abnormal_neuroendocrine_gland1.10951188
86MP0009697_abnormal_copulation1.10424390
87MP0002088_abnormal_embryonic_growth/wei1.10392213
88MP0005253_abnormal_eye_physiology1.09696135
89MP0001486_abnormal_startle_reflex1.08799304
90MP0001853_heart_inflammation1.08718421
91MP0003698_abnormal_male_reproductive1.08353689
92MP0009745_abnormal_behavioral_response1.08070471
93MP0006054_spinal_hemorrhage1.08033275
94MP0004811_abnormal_neuron_physiology1.07168073
95MP0001968_abnormal_touch/_nociception1.05740748
96MP0005645_abnormal_hypothalamus_physiol1.03599028
97MP0003861_abnormal_nervous_system1.03337129
98MP0004147_increased_porphyrin_level1.03260287
99MP0002723_abnormal_immune_serum1.03213121
100MP0005423_abnormal_somatic_nervous1.02657409
101MP0000049_abnormal_middle_ear1.01158899
102MP0004142_abnormal_muscle_tone1.00861149
103MP0005025_abnormal_response_to1.00699916
104MP0002572_abnormal_emotion/affect_behav1.00065876
105MP0002734_abnormal_mechanical_nocicepti0.98360396
106MP0002210_abnormal_sex_determination0.98289947
107MP0002557_abnormal_social/conspecific_i0.98109215
108MP0002184_abnormal_innervation0.97962420
109MP0000858_altered_metastatic_potential0.97743758
110MP0001119_abnormal_female_reproductive0.97478616
111MP0000685_abnormal_immune_system0.97466833
112MP0002086_abnormal_extraembryonic_tissu0.97007275
113MP0000955_abnormal_spinal_cord0.96858482
114MP0003119_abnormal_digestive_system0.96434513
115MP0003941_abnormal_skin_development0.95353622
116MP0001286_abnormal_eye_development0.95110054
117MP0003943_abnormal_hepatobiliary_system0.94221936
118MP0002735_abnormal_chemical_nociception0.94004981
119MP0002085_abnormal_embryonic_tissue0.93771244
120MP0003136_yellow_coat_color0.93467286
121MP0002063_abnormal_learning/memory/cond0.92969499
122MP0005386_behavior/neurological_phenoty0.92628079
123MP0004924_abnormal_behavior0.92628079
124MP0002405_respiratory_system_inflammati0.92506295
125MP0005000_abnormal_immune_tolerance0.92277585
126MP0002006_tumorigenesis0.91276547
127MP0010155_abnormal_intestine_physiology0.91192416
128MP0003315_abnormal_perineum_morphology0.90667776
129MP0005084_abnormal_gallbladder_morpholo0.90652742
130MP0001346_abnormal_lacrimal_gland0.90255194
131MP0002419_abnormal_innate_immunity0.88454194
132MP0002938_white_spotting0.87980017
133MP0002084_abnormal_developmental_patter0.86971272
134MP0001293_anophthalmia0.86693713
135MP0002152_abnormal_brain_morphology0.86552218
136MP0002064_seizures0.86525546
137MP0002653_abnormal_ependyma_morphology0.86197789
138MP0002160_abnormal_reproductive_system0.85744205
139MP0000465_gastrointestinal_hemorrhage0.84914945
140MP0002882_abnormal_neuron_morphology0.84448451
141MP0002752_abnormal_somatic_nervous0.82776081
142MP0003755_abnormal_palate_morphology0.81771386
143MP0001188_hyperpigmentation0.81124314
144MP0005389_reproductive_system_phenotype0.81035337
145MP0004197_abnormal_fetal_growth/weight/0.78999617
146MP0002166_altered_tumor_susceptibility0.78763508
147MP0001145_abnormal_male_reproductive0.78318690
148MP0001764_abnormal_homeostasis0.78024788
149MP0005391_vision/eye_phenotype0.77825244
150MP0009703_decreased_birth_body0.77216898
151MP0000358_abnormal_cell_content/0.76991785
152MP0003436_decreased_susceptibility_to0.75216681
153MP0005464_abnormal_platelet_physiology0.74248708
154MP0006036_abnormal_mitochondrial_physio0.73544200
155MP0001186_pigmentation_phenotype0.69435999
156MP0005384_cellular_phenotype0.69427851
157MP0000653_abnormal_sex_gland0.68835632
158MP0004133_heterotaxia0.68350686
159MP0005387_immune_system_phenotype0.68052513
160MP0001790_abnormal_immune_system0.68052513
161MP0001929_abnormal_gametogenesis0.67713439
162MP0000371_diluted_coat_color0.66605707
163MP0001873_stomach_inflammation0.65259981

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.50993451
2Chromsome breakage (HP:0040012)4.45801971
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.04622418
4Reticulocytopenia (HP:0001896)3.97263084
5Aplastic anemia (HP:0001915)3.65898700
6Abnormal number of erythroid precursors (HP:0012131)3.52832865
7Abnormality of the anterior horn cell (HP:0006802)3.49369150
8Degeneration of anterior horn cells (HP:0002398)3.49369150
9Abnormality of the preputium (HP:0100587)3.44831267
10Abnormality of chromosome stability (HP:0003220)3.42823251
11Abnormality of the labia minora (HP:0012880)3.41907484
12Abnormality of cells of the erythroid lineage (HP:0012130)3.37094323
13Oral leukoplakia (HP:0002745)3.33339636
14Meckel diverticulum (HP:0002245)3.29407648
15Colon cancer (HP:0003003)3.27471531
16Thrombocytosis (HP:0001894)3.25904016
17Acute necrotizing encephalopathy (HP:0006965)3.24949120
18Abnormality of the ileum (HP:0001549)3.17881068
19Myelodysplasia (HP:0002863)3.12281665
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.10292242
21Abnormal mitochondria in muscle tissue (HP:0008316)3.01759898
22IgM deficiency (HP:0002850)2.98839610
2311 pairs of ribs (HP:0000878)2.97397162
24Acute encephalopathy (HP:0006846)2.95158566
25Type I transferrin isoform profile (HP:0003642)2.91487163
26Cortical dysplasia (HP:0002539)2.87770876
27Bone marrow hypocellularity (HP:0005528)2.86402520
28Abnormality of DNA repair (HP:0003254)2.77715463
29Patellar aplasia (HP:0006443)2.74326715
30Progressive macrocephaly (HP:0004481)2.73770760
31Poikiloderma (HP:0001029)2.72520380
32Agnosia (HP:0010524)2.68682564
33Rough bone trabeculation (HP:0100670)2.67085480
34Premature graying of hair (HP:0002216)2.65504814
35Increased CSF lactate (HP:0002490)2.61734071
36Mitochondrial inheritance (HP:0001427)2.58753056
37Breast hypoplasia (HP:0003187)2.58642744
38Small intestinal stenosis (HP:0012848)2.58341679
39Duodenal stenosis (HP:0100867)2.58341679
40Aplasia/Hypoplasia of the patella (HP:0006498)2.58216927
41Medulloblastoma (HP:0002885)2.51398721
42Hepatic necrosis (HP:0002605)2.49561110
43Microretrognathia (HP:0000308)2.48330585
44Absent thumb (HP:0009777)2.47977877
45True hermaphroditism (HP:0010459)2.45709206
46Medial flaring of the eyebrow (HP:0010747)2.41444762
47Lymphoma (HP:0002665)2.41289143
48Optic nerve coloboma (HP:0000588)2.40634596
49Gait imbalance (HP:0002141)2.40632552
50Clubbing of toes (HP:0100760)2.40613076
51Congenital primary aphakia (HP:0007707)2.40315965
52Nephrogenic diabetes insipidus (HP:0009806)2.38767998
53Retinal dysplasia (HP:0007973)2.36210934
54Abnormality of midbrain morphology (HP:0002418)2.33451814
55Molar tooth sign on MRI (HP:0002419)2.33451814
56Pancreatic fibrosis (HP:0100732)2.32965406
57Carpal bone hypoplasia (HP:0001498)2.32874573
58Pancreatic cysts (HP:0001737)2.31730236
59Increased serum pyruvate (HP:0003542)2.30436882
60Ectopic kidney (HP:0000086)2.29757834
61Reduced antithrombin III activity (HP:0001976)2.27412568
62Abnormality of glycolysis (HP:0004366)2.26711806
63Abnormal lung lobation (HP:0002101)2.25798759
64Hyperglycinemia (HP:0002154)2.22858166
65Amaurosis fugax (HP:0100576)2.21995734
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.21242612
67Selective tooth agenesis (HP:0001592)2.20316960
68Abnormality of the prostate (HP:0008775)2.20134221
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19333476
70Abnormality of the duodenum (HP:0002246)2.18742229
71Pallor (HP:0000980)2.18624469
72Volvulus (HP:0002580)2.17881141
73Cerebral edema (HP:0002181)2.16020349
74Entropion (HP:0000621)2.13723990
75Type 2 muscle fiber atrophy (HP:0003554)2.13355813
76Sloping forehead (HP:0000340)2.13039223
77Abnormality of alanine metabolism (HP:0010916)2.12353954
78Hyperalaninemia (HP:0003348)2.12353954
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12353954
80Myositis (HP:0100614)2.12300400
81Intestinal atresia (HP:0011100)2.09584133
82Macrocytic anemia (HP:0001972)2.07186394
83Petechiae (HP:0000967)2.06785585
84Pancytopenia (HP:0001876)2.06531499
85Lissencephaly (HP:0001339)2.05493360
86Oligodactyly (hands) (HP:0001180)2.05440050
87Methylmalonic acidemia (HP:0002912)2.05235355
88Abnormal trabecular bone morphology (HP:0100671)2.04316967
89Gonadotropin excess (HP:0000837)2.04254427
90Nephroblastoma (Wilms tumor) (HP:0002667)2.03524899
91Recurrent abscess formation (HP:0002722)2.03352122
92Increased nuchal translucency (HP:0010880)2.02890553
93Spinal muscular atrophy (HP:0007269)2.01639921
94Cellular immunodeficiency (HP:0005374)2.01629799
95Pulmonary fibrosis (HP:0002206)2.01207631
96Nephronophthisis (HP:0000090)2.01084209
97Muscle fiber atrophy (HP:0100295)2.00793636
98Acute myeloid leukemia (HP:0004808)2.00501015
99Ependymoma (HP:0002888)1.99640730
100Neoplasm of the pancreas (HP:0002894)1.99622380
101Genital tract atresia (HP:0001827)1.99314225
102Embryonal renal neoplasm (HP:0011794)1.98331879
103Increased serum lactate (HP:0002151)1.97473632
104Triphalangeal thumb (HP:0001199)1.97177829
105Tracheoesophageal fistula (HP:0002575)1.96013806
106Elevated erythrocyte sedimentation rate (HP:0003565)1.95223684
107Vaginal atresia (HP:0000148)1.94222704
108Abnormality of the carotid arteries (HP:0005344)1.93537657
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93035008
110Abnormal protein N-linked glycosylation (HP:0012347)1.93035008
111Abnormal protein glycosylation (HP:0012346)1.93035008
112Abnormal glycosylation (HP:0012345)1.93035008
113Impulsivity (HP:0100710)1.92934735
114Supernumerary spleens (HP:0009799)1.92810393
115Lipid accumulation in hepatocytes (HP:0006561)1.92330080
116IgG deficiency (HP:0004315)1.89844720
117Increased hepatocellular lipid droplets (HP:0006565)1.88025205
118Acute lymphatic leukemia (HP:0006721)1.87392938
119Glioma (HP:0009733)1.86717152
120Tubulointerstitial nephritis (HP:0001970)1.85888025
121Microvesicular hepatic steatosis (HP:0001414)1.83126073
122Basal cell carcinoma (HP:0002671)1.80369871
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.79979621
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79087736
125Hypoplasia of the pons (HP:0012110)1.78697503
126Astrocytoma (HP:0009592)1.78202600
127Abnormality of the astrocytes (HP:0100707)1.78202600
128Duplicated collecting system (HP:0000081)1.77572662
129Cleft eyelid (HP:0000625)1.76905244
130Absent forearm bone (HP:0003953)1.76860164
131Aplasia involving forearm bones (HP:0009822)1.76860164
132Chronic otitis media (HP:0000389)1.76746030
133Absent radius (HP:0003974)1.76227516
134Abnormality of the renal collecting system (HP:0004742)1.76119630
135Astigmatism (HP:0000483)1.76025746
136Hepatocellular necrosis (HP:0001404)1.75725251
137Hypoplastic pelvis (HP:0008839)1.74820200
138Leukopenia (HP:0001882)1.74796877
139Exertional dyspnea (HP:0002875)1.73541148
140Squamous cell carcinoma (HP:0002860)1.73366626
141Preaxial hand polydactyly (HP:0001177)1.73309694
142Bifid tongue (HP:0010297)1.71648048
143Poor head control (HP:0002421)1.71246205
144Lactic acidosis (HP:0003128)1.71073624
145Short middle phalanx of the 5th finger (HP:0004220)1.71026811
146Oligodactyly (HP:0012165)1.71022548
147Optic disc pallor (HP:0000543)1.70799499
148Broad foot (HP:0001769)1.70577157
149Horseshoe kidney (HP:0000085)1.70300462
150Poor coordination (HP:0002370)1.70256429
151Drooling (HP:0002307)1.68260745
152Cutaneous melanoma (HP:0012056)1.67957557
153Neoplasm of the colon (HP:0100273)1.67441205
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.67037802
155Cerebral hypomyelination (HP:0006808)1.66534572
156Aseptic necrosis (HP:0010885)1.66442337
157Missing ribs (HP:0000921)1.66195240
158Abnormal spermatogenesis (HP:0008669)1.66029670
159Abnormality of serine family amino acid metabolism (HP:0010894)1.65623494
160Abnormality of glycine metabolism (HP:0010895)1.65623494
161Abnormality of the renal medulla (HP:0100957)1.63962825
162Aganglionic megacolon (HP:0002251)1.62983161
163Postaxial foot polydactyly (HP:0001830)1.62477374
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.61555352
165Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.61555352
166Abnormality of serum amino acid levels (HP:0003112)1.61230258
167Specific learning disability (HP:0001328)1.61077706
168Short tibia (HP:0005736)1.59314954
169Hyperglycinuria (HP:0003108)1.58820793
170Shoulder girdle muscle weakness (HP:0003547)1.58403015
171Abnormal biliary tract physiology (HP:0012439)1.58173571
172Bile duct proliferation (HP:0001408)1.58173571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.83162933
2BUB13.81655711
3EIF2AK13.35311496
4CDC73.02179916
5SRPK12.83015030
6STK162.79718435
7TRIM282.62251293
8BRSK22.61003216
9PLK42.41381774
10NEK22.34409640
11WNK32.32736961
12VRK12.18822062
13VRK22.14602610
14BCR2.11577352
15ACVR1B2.09887733
16EIF2AK32.06875323
17MAP4K22.05611771
18CASK2.04390417
19TSSK62.02088589
20MKNK11.97758735
21PASK1.94622249
22MARK11.92494118
23ZAK1.84298731
24PLK11.82031574
25PNCK1.80036764
26MAP3K41.79459943
27MAP4K11.78044636
28BRSK11.76341644
29CCNB11.75797328
30ATR1.69769978
31PLK31.69020577
32NME21.64215900
33MAP2K71.63027589
34TTK1.63027560
35TNIK1.56690340
36AURKB1.56221269
37TGFBR11.50591015
38TEC1.49542606
39EIF2AK21.46321154
40CDK71.45699894
41EPHA41.44169907
42DYRK31.42517537
43MKNK21.37418389
44CSNK1G31.37293662
45NEK11.36196917
46RPS6KA41.35071382
47TLK11.34204186
48PIM21.33521238
49PLK21.32481885
50MAPK131.32480936
51DYRK21.31471497
52RPS6KB21.30703644
53AKT31.29925356
54CSNK1G21.29591714
55IRAK41.28014466
56CDK81.26644193
57CSNK1G11.23972475
58BCKDK1.22717287
59CSNK1A1L1.21247846
60BMPR1B1.20747284
61KIT1.20577334
62BTK1.17973025
63TXK1.15487132
64CHEK21.15272712
65MAP2K31.09178874
66BRD41.08861111
67FLT31.08182337
68MINK11.05896977
69NME11.05656937
70PDK21.03954254
71STK101.02635530
72MAP3K141.00315171
73UHMK10.93980782
74STK40.93774334
75CHEK10.93711119
76CDK40.91022250
77AURKA0.90637596
78PIM10.89633624
79FRK0.86867706
80IRAK30.86346602
81PRKCG0.80355774
82JAK30.80177141
83CDK120.79489684
84ERBB30.78842236
85ATM0.77138730
86CLK10.76308637
87CSF1R0.74448553
88CDK190.73248494
89PAK60.72187240
90CSNK2A10.71560570
91BRAF0.71460122
92CDK180.71277991
93MAP3K120.71238460
94MAP3K80.68537525
95PAK40.67208418
96YES10.66668604
97CDK150.65019655
98CDK140.65004571
99CDK20.64407048
100CDK11A0.63586935
101CDK30.60196821
102TAF10.59695686
103CSNK1E0.59517205
104CSNK2A20.57908171
105DAPK10.57850457
106MAP3K110.57769532
107NEK90.56712555
108IKBKB0.56283892
109TESK20.56205030
110BLK0.53521444
111EEF2K0.52862772
112CHUK0.51396009
113SYK0.51263560
114LYN0.51226189
115STK38L0.51194099
116ZAP700.50418516
117RPS6KC10.49522171
118RPS6KL10.49522171
119MAP3K30.49118954
120RPS6KA60.48964307
121PAK30.48957859
122CDK10.47667077
123PRKDC0.46901469
124KDR0.44905241
125LATS10.43899325
126INSRR0.42917299
127PHKG20.42399564
128PHKG10.42399564
129CDK60.42197739
130DYRK1A0.41451363
131PRKCE0.40641161
132PAK10.40590469
133CSNK1A10.40543876
134PRKCI0.40228652
135MYLK0.40218946
136MARK30.40117473
137GRK10.39761530
138MAPKAPK30.39696868
139SIK30.39512930
140ERBB40.38625672
141RPS6KB10.38031455
142PINK10.37857765
143MAPKAPK50.37258199
144CAMK2A0.37212516
145CSNK1D0.36902477
146STK30.35589002
147CDK90.35235524
148SIK20.33338422
149PBK0.33167200
150RPS6KA50.29597421
151STK240.28962269
152EPHA20.28835285
153NUAK10.28634506
154MAPKAPK20.28458154
155SCYL20.28371136
156MST40.28268614

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.98980144
2Mismatch repair_Homo sapiens_hsa034304.28961486
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.33745218
4Homologous recombination_Homo sapiens_hsa034403.32246623
5* Base excision repair_Homo sapiens_hsa034103.24639456
6Ribosome_Homo sapiens_hsa030103.18314133
7RNA polymerase_Homo sapiens_hsa030203.18247189
8Proteasome_Homo sapiens_hsa030503.06092156
9Spliceosome_Homo sapiens_hsa030403.00138253
10Nucleotide excision repair_Homo sapiens_hsa034202.90243519
11RNA transport_Homo sapiens_hsa030132.64370162
12Cell cycle_Homo sapiens_hsa041102.57589056
13Fanconi anemia pathway_Homo sapiens_hsa034602.49911535
14Pyrimidine metabolism_Homo sapiens_hsa002402.49828669
15Non-homologous end-joining_Homo sapiens_hsa034502.39799668
16One carbon pool by folate_Homo sapiens_hsa006702.33027922
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18675848
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03648628
19RNA degradation_Homo sapiens_hsa030182.01540203
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97000444
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90743427
22Basal transcription factors_Homo sapiens_hsa030221.87064928
23Propanoate metabolism_Homo sapiens_hsa006401.73007927
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69074204
25p53 signaling pathway_Homo sapiens_hsa041151.52733727
26Steroid biosynthesis_Homo sapiens_hsa001001.51591980
27Nicotine addiction_Homo sapiens_hsa050331.51235770
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49508142
29Purine metabolism_Homo sapiens_hsa002301.46776639
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45807265
31mRNA surveillance pathway_Homo sapiens_hsa030151.45581785
32Fatty acid elongation_Homo sapiens_hsa000621.42079626
33Butanoate metabolism_Homo sapiens_hsa006501.37199879
34Pyruvate metabolism_Homo sapiens_hsa006201.26061391
35Herpes simplex infection_Homo sapiens_hsa051681.25669962
36Protein export_Homo sapiens_hsa030601.24662109
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24433160
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18788906
39Primary immunodeficiency_Homo sapiens_hsa053401.17730915
40Epstein-Barr virus infection_Homo sapiens_hsa051691.17190090
41Phototransduction_Homo sapiens_hsa047441.13667786
42Antigen processing and presentation_Homo sapiens_hsa046121.03994502
43Legionellosis_Homo sapiens_hsa051340.99183056
44Alzheimers disease_Homo sapiens_hsa050100.97741840
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95661808
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95475698
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91085234
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90849230
49Systemic lupus erythematosus_Homo sapiens_hsa053220.86828249
50Measles_Homo sapiens_hsa051620.82804087
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81657275
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.81177813
53Selenocompound metabolism_Homo sapiens_hsa004500.76981498
54Fatty acid metabolism_Homo sapiens_hsa012120.76941946
55Cardiac muscle contraction_Homo sapiens_hsa042600.76873318
56Synaptic vesicle cycle_Homo sapiens_hsa047210.76518553
57Peroxisome_Homo sapiens_hsa041460.75811176
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.74813867
59Viral carcinogenesis_Homo sapiens_hsa052030.74121596
60Pentose phosphate pathway_Homo sapiens_hsa000300.70276828
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68597334
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68331964
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67903464
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67031385
65HTLV-I infection_Homo sapiens_hsa051660.66348159
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66155089
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.65944837
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65871822
69Hematopoietic cell lineage_Homo sapiens_hsa046400.65685948
70Allograft rejection_Homo sapiens_hsa053300.65539937
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65417747
72Oocyte meiosis_Homo sapiens_hsa041140.65345361
73Folate biosynthesis_Homo sapiens_hsa007900.65101757
74N-Glycan biosynthesis_Homo sapiens_hsa005100.64149109
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60918827
76GABAergic synapse_Homo sapiens_hsa047270.60072793
77Circadian rhythm_Homo sapiens_hsa047100.59019814
78Collecting duct acid secretion_Homo sapiens_hsa049660.57078831
79Influenza A_Homo sapiens_hsa051640.57016814
80Taste transduction_Homo sapiens_hsa047420.56351736
81Thyroid cancer_Homo sapiens_hsa052160.55966614
82beta-Alanine metabolism_Homo sapiens_hsa004100.55285801
83Lysine degradation_Homo sapiens_hsa003100.54359230
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50902215
85Huntingtons disease_Homo sapiens_hsa050160.50883881
86Leishmaniasis_Homo sapiens_hsa051400.50837733
87Galactose metabolism_Homo sapiens_hsa000520.47677404
88Olfactory transduction_Homo sapiens_hsa047400.47337467
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46056321
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.45503059
91Arginine and proline metabolism_Homo sapiens_hsa003300.45223058
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43924619
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43725595
94Hippo signaling pathway_Homo sapiens_hsa043900.43497806
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43453993
96Graft-versus-host disease_Homo sapiens_hsa053320.42945532
97Shigellosis_Homo sapiens_hsa051310.42756660
98Hedgehog signaling pathway_Homo sapiens_hsa043400.42559280
99* Apoptosis_Homo sapiens_hsa042100.42276097
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.41774453
101Hepatitis B_Homo sapiens_hsa051610.41054573
102Dopaminergic synapse_Homo sapiens_hsa047280.38666970
103Parkinsons disease_Homo sapiens_hsa050120.38306471
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37550636
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37221225
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.35555877
107Type I diabetes mellitus_Homo sapiens_hsa049400.34909954
108Basal cell carcinoma_Homo sapiens_hsa052170.34359994
109Biosynthesis of amino acids_Homo sapiens_hsa012300.33486154
110Vibrio cholerae infection_Homo sapiens_hsa051100.32469190
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.31722461
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31708555
113Vitamin B6 metabolism_Homo sapiens_hsa007500.31541829
114Ether lipid metabolism_Homo sapiens_hsa005650.31267584
115Regulation of autophagy_Homo sapiens_hsa041400.30700452
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30494700
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.30444869
118Arachidonic acid metabolism_Homo sapiens_hsa005900.30239469
119Small cell lung cancer_Homo sapiens_hsa052220.29739178
120Glutathione metabolism_Homo sapiens_hsa004800.29709741
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29308721
122Circadian entrainment_Homo sapiens_hsa047130.29185435
123Wnt signaling pathway_Homo sapiens_hsa043100.28243291
124Autoimmune thyroid disease_Homo sapiens_hsa053200.27907010
125B cell receptor signaling pathway_Homo sapiens_hsa046620.27787337
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27724881
127MicroRNAs in cancer_Homo sapiens_hsa052060.27721047
128Asthma_Homo sapiens_hsa053100.27423616
129Glutamatergic synapse_Homo sapiens_hsa047240.27361003
130Acute myeloid leukemia_Homo sapiens_hsa052210.27209131
131Fatty acid degradation_Homo sapiens_hsa000710.27008496
132TGF-beta signaling pathway_Homo sapiens_hsa043500.26925871
133Fructose and mannose metabolism_Homo sapiens_hsa000510.26893312
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24851268
135Amphetamine addiction_Homo sapiens_hsa050310.24798273
136Tryptophan metabolism_Homo sapiens_hsa003800.24696871
137Viral myocarditis_Homo sapiens_hsa054160.23619368
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23044222
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22288684
140Morphine addiction_Homo sapiens_hsa050320.22047321
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21067854
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19736210
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19636793
144Alcoholism_Homo sapiens_hsa050340.19550918
145Metabolic pathways_Homo sapiens_hsa011000.18657954
146Other glycan degradation_Homo sapiens_hsa005110.16903978
147Colorectal cancer_Homo sapiens_hsa052100.16709075
148Notch signaling pathway_Homo sapiens_hsa043300.15590445
149Pertussis_Homo sapiens_hsa051330.15207395
150Carbon metabolism_Homo sapiens_hsa012000.14582734
151Sulfur relay system_Homo sapiens_hsa041220.13942189
152Tuberculosis_Homo sapiens_hsa051520.13911918
153Oxidative phosphorylation_Homo sapiens_hsa001900.13258959

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