PARP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.21586705
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.01566133
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.01566133
4antigen processing and presentation of endogenous antigen (GO:0019883)4.91427969
5positive regulation of gamma-delta T cell activation (GO:0046645)4.84589239
6regulation of gamma-delta T cell differentiation (GO:0045586)3.84415002
7regulation of interleukin-12 biosynthetic process (GO:0045075)3.79520444
8regulation of gamma-delta T cell activation (GO:0046643)3.78025932
9modulation by symbiont of host defense response (GO:0052031)3.68701628
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.68701628
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.68701628
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.68701628
13modulation by symbiont of host immune response (GO:0052553)3.68701628
14positive regulation by symbiont of host defense response (GO:0052509)3.68701628
15hypotonic response (GO:0006971)3.53672942
16positive regulation of interferon-alpha production (GO:0032727)3.41628051
17regulation of interferon-beta biosynthetic process (GO:0045357)3.41381156
18response to type I interferon (GO:0034340)3.36332515
19negative regulation of cell killing (GO:0031342)3.35059140
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.35059140
21positive thymic T cell selection (GO:0045059)3.32040322
22regulation of interferon-alpha production (GO:0032647)3.31048309
23positive regulation of natural killer cell differentiation (GO:0032825)3.27807683
24cellular response to type I interferon (GO:0071357)3.27520215
25type I interferon signaling pathway (GO:0060337)3.27520215
26detection of other organism (GO:0098543)3.26735602
27pinocytosis (GO:0006907)3.23575843
28leukocyte aggregation (GO:0070486)3.20889744
29detection of molecule of bacterial origin (GO:0032490)3.17601148
30JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.17100323
31negative thymic T cell selection (GO:0045060)3.14341141
32NIK/NF-kappaB signaling (GO:0038061)3.12184657
33neutrophil activation involved in immune response (GO:0002283)3.10532407
34negative T cell selection (GO:0043383)3.06231498
35response to muramyl dipeptide (GO:0032495)3.02089102
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01286929
37regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.00367726
38regulation of B cell receptor signaling pathway (GO:0050855)2.99571058
39detection of bacterium (GO:0016045)2.99149631
40detection of external biotic stimulus (GO:0098581)2.98700631
41cellular extravasation (GO:0045123)2.96564566
42growth hormone receptor signaling pathway (GO:0060396)2.94844185
43positive regulation of humoral immune response (GO:0002922)2.90831851
44interferon-gamma-mediated signaling pathway (GO:0060333)2.88680496
45positive regulation of B cell differentiation (GO:0045579)2.87475171
46thymic T cell selection (GO:0045061)2.87192950
47membrane raft organization (GO:0031579)2.87119457
48Golgi transport vesicle coating (GO:0048200)2.87109370
49COPI coating of Golgi vesicle (GO:0048205)2.87109370
50antigen processing and presentation via MHC class Ib (GO:0002475)2.85387573
51immunoglobulin mediated immune response (GO:0016064)2.84465497
52protein localization to endosome (GO:0036010)2.83273207
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.83086322
54leukocyte cell-cell adhesion (GO:0007159)2.81013815
55neutrophil activation (GO:0042119)2.80717933
56macrophage activation involved in immune response (GO:0002281)2.80226016
57T cell migration (GO:0072678)2.79978160
58positive regulation of Cdc42 GTPase activity (GO:0043089)2.76538356
59response to interleukin-15 (GO:0070672)2.76253986
60regulation of B cell differentiation (GO:0045577)2.76124847
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.75736967
62granulocyte activation (GO:0036230)2.72031799
63positive regulation of antigen processing and presentation (GO:0002579)2.70677693
64embryonic process involved in female pregnancy (GO:0060136)2.69003151
65peptide catabolic process (GO:0043171)2.68620138
66response to peptidoglycan (GO:0032494)2.67696721
67myeloid dendritic cell differentiation (GO:0043011)2.67351969
68cellular response to zinc ion (GO:0071294)2.67295231
69T cell selection (GO:0045058)2.67063719
70interferon-gamma production (GO:0032609)2.66443070
71tolerance induction (GO:0002507)2.65462698
72response to host immune response (GO:0052572)2.64963953
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64963953
74response to laminar fluid shear stress (GO:0034616)2.63861705
75myeloid dendritic cell activation (GO:0001773)2.63429563
76barbed-end actin filament capping (GO:0051016)2.63410389
77positive regulation of interferon-beta production (GO:0032728)2.63071528
78regulation of response to interferon-gamma (GO:0060330)2.62178039
79T-helper 1 type immune response (GO:0042088)2.61047631
80regulation of alpha-beta T cell proliferation (GO:0046640)2.60333707
81positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.56361439
82regulation of natural killer cell differentiation (GO:0032823)2.56027897
83regulation of RIG-I signaling pathway (GO:0039535)2.55882995
84regulation of necroptotic process (GO:0060544)2.53635816
85regulation of T cell tolerance induction (GO:0002664)2.53617761
86regulation of leukocyte degranulation (GO:0043300)2.52854126
87mature B cell differentiation (GO:0002335)2.52768387
88cellular response to growth hormone stimulus (GO:0071378)2.52052823
89B cell receptor signaling pathway (GO:0050853)2.52009279
90regulation of dendritic cell antigen processing and presentation (GO:0002604)2.51937100
91detection of biotic stimulus (GO:0009595)2.51403094
92lipopolysaccharide-mediated signaling pathway (GO:0031663)2.50857902
93response to host (GO:0075136)2.50667022
94response to host defenses (GO:0052200)2.50667022
95response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.50667022
96response to protozoan (GO:0001562)2.50631430
97positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49564694
98positive regulation of interleukin-12 production (GO:0032735)2.49238799
99regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.49004550
100negative regulation of erythrocyte differentiation (GO:0045647)2.48332825
101defense response to protozoan (GO:0042832)2.47112746
102hepatocyte apoptotic process (GO:0097284)2.45891645
103regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.44429720
104response to interferon-alpha (GO:0035455)2.44388864
105negative regulation of interleukin-12 production (GO:0032695)2.43319936
106regulation of type I interferon-mediated signaling pathway (GO:0060338)2.43308465
107positive regulation of interleukin-2 production (GO:0032743)2.42820996
108positive T cell selection (GO:0043368)2.42623698
109positive regulation of immunoglobulin mediated immune response (GO:0002891)2.40424792
110positive regulation of B cell mediated immunity (GO:0002714)2.40424792
111regulation of myeloid leukocyte mediated immunity (GO:0002886)2.39266203
112germinal center formation (GO:0002467)2.38283936
113positive regulation of isotype switching (GO:0045830)2.38193620
114B cell mediated immunity (GO:0019724)2.38127156
115glomerular visceral epithelial cell development (GO:0072015)2.37625384
116positive regulation of histone deacetylation (GO:0031065)2.36903995
117cytokine secretion (GO:0050663)2.36636283
118regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35948640
119cellular response to interleukin-15 (GO:0071350)2.35740214
120regulation of interleukin-12 production (GO:0032655)2.35338262
121T-helper cell differentiation (GO:0042093)2.35271735
122CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.35271735
123positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34968078
124regulation of cholesterol storage (GO:0010885)2.33499442
125regulation of mast cell degranulation (GO:0043304)2.33355502
126skin morphogenesis (GO:0043589)2.24556437
127definitive hemopoiesis (GO:0060216)2.24407270
128mannose metabolic process (GO:0006013)2.23053089
129cellular response to ethanol (GO:0071361)2.21627160
130positive regulation of macrophage differentiation (GO:0045651)2.21145514
131cell adhesion mediated by integrin (GO:0033627)2.21115538
132glycosphingolipid catabolic process (GO:0046479)2.21006154
133production of molecular mediator involved in inflammatory response (GO:0002532)2.19373413
134iron ion import (GO:0097286)2.18998193
135mature B cell differentiation involved in immune response (GO:0002313)2.18014607
136nuclear pore complex assembly (GO:0051292)2.17849503
137positive regulation of leukocyte degranulation (GO:0043302)2.17379983
138regulation of tolerance induction (GO:0002643)2.16053655
139myeloid cell activation involved in immune response (GO:0002275)2.13839663
140stress fiber assembly (GO:0043149)2.13468971
141positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.12891627
142histone H3-K36 demethylation (GO:0070544)2.12505444
143negative regulation of lymphocyte mediated immunity (GO:0002707)2.12005025
144regulation of extracellular matrix disassembly (GO:0010715)2.11954051
145dendritic cell migration (GO:0036336)2.11875376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.25860226
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.68542973
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.16863473
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.89672177
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.84135637
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.74616131
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.13049186
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.00071275
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.96871389
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.87605520
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78945102
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.76799717
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74096417
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.66929531
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.49153019
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46443482
17RUNX_20019798_ChIP-Seq_JUKART_Human2.40899837
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.36184435
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21000388
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.18306261
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14178631
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.10875604
23SCL_19346495_ChIP-Seq_HPC-7_Human1.99056733
24MYB_26560356_Chip-Seq_TH2_Human1.97873469
25* MAF_26560356_Chip-Seq_TH1_Human1.96031123
26GATA1_22025678_ChIP-Seq_K562_Human1.92025969
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89261226
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89256069
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85256826
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.80675005
31* MYB_26560356_Chip-Seq_TH1_Human1.78546088
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.72801030
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66510879
34VDR_21846776_ChIP-Seq_THP-1_Human1.62819875
35VDR_24763502_ChIP-Seq_THP-1_Human1.62816552
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61734594
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60911401
38SPI1_23127762_ChIP-Seq_K562_Human1.57361176
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.56627090
40TCF7_22412390_ChIP-Seq_EML_Mouse1.55377498
41* LXR_22158963_ChIP-Seq_LIVER_Mouse1.52286548
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.51163861
43MYC_22102868_ChIP-Seq_BL_Human1.51026936
44UTX_26944678_Chip-Seq_JUKART_Human1.50624593
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50030521
46* SPI1_23547873_ChIP-Seq_NB4_Human1.49085411
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47936381
48E2F7_22180533_ChIP-Seq_HELA_Human1.47734307
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46926608
50PU_27001747_Chip-Seq_BMDM_Mouse1.46831995
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46179292
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44709423
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43569903
54VDR_24787735_ChIP-Seq_THP-1_Human1.35838802
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34954365
56* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34063418
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32998493
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.30953780
59GATA3_27048872_Chip-Seq_THYMUS_Human1.28871785
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.26078898
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25103392
62* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24603094
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22992354
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21476957
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20015322
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.19973792
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19642908
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18628165
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.16952887
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16559338
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16433845
72KDM2B_26808549_Chip-Seq_DND41_Human1.16236420
73* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16228070
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16120869
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14472161
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14411663
77* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13443230
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.12465238
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11808740
80GATA2_19941826_ChIP-Seq_K562_Human1.09062599
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08614207
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.08594260
83* GATA6_25053715_ChIP-Seq_YYC3_Human1.07575522
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07263877
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06524061
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06451187
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06223026
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05813489
89* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05630434
90* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05630434
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05302424
92TFEB_21752829_ChIP-Seq_HELA_Human1.04630333
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04432228
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02836108
95CDX2_20551321_ChIP-Seq_CACO-2_Human1.01770761
96* MAF_26560356_Chip-Seq_TH2_Human0.99444817
97GATA1_19941826_ChIP-Seq_K562_Human0.99411422
98P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98583873
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98196523
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98156946
101* RACK7_27058665_Chip-Seq_MCF-7_Human0.97437719
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97400668
103AR_21909140_ChIP-Seq_LNCAP_Human0.97287810
104GATA3_26560356_Chip-Seq_TH2_Human0.96959045
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96390259
106CLOCK_20551151_ChIP-Seq_293T_Human0.93921937
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92088788
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91055584
109SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90218189
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89946565
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89254053
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.87641005
113TBX20_22328084_ChIP-Seq_HEART_Mouse0.87641005
114* SOX2_20726797_ChIP-Seq_SW620_Human0.87381866
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87177848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.46397946
2MP0000685_abnormal_immune_system2.95205531
3MP0005387_immune_system_phenotype2.78842475
4MP0001790_abnormal_immune_system2.78842475
5MP0009785_altered_susceptibility_to2.77675406
6MP0003436_decreased_susceptibility_to2.67357556
7MP0005671_abnormal_response_to2.56568264
8MP0001800_abnormal_humoral_immune2.51894220
9MP0003300_gastrointestinal_ulcer2.39240399
10MP0005000_abnormal_immune_tolerance2.37745050
11MP0003303_peritoneal_inflammation2.35946267
12MP0004510_myositis2.31613712
13MP0003724_increased_susceptibility_to2.30126331
14MP0005025_abnormal_response_to2.27187127
15MP0002452_abnormal_antigen_presenting2.24070977
16MP0002166_altered_tumor_susceptibility2.23993895
17MP0002148_abnormal_hypersensitivity_rea2.20848550
18MP0006082_CNS_inflammation2.20753456
19MP0002419_abnormal_innate_immunity2.17775507
20MP0002723_abnormal_immune_serum2.17518357
21MP0005451_abnormal_body_composition2.03673129
22MP0004947_skin_inflammation2.00089426
23MP0001819_abnormal_immune_cell1.98080693
24MP0002420_abnormal_adaptive_immunity1.97181839
25MP0010155_abnormal_intestine_physiology1.92764053
26MP0005464_abnormal_platelet_physiology1.86763721
27MP0010234_abnormal_vibrissa_follicle1.86688617
28MP0003763_abnormal_thymus_physiology1.84058022
29MP0002006_tumorigenesis1.81245347
30MP0001853_heart_inflammation1.77381881
31MP0001873_stomach_inflammation1.75957986
32MP0008260_abnormal_autophagy1.75099884
33MP0002405_respiratory_system_inflammati1.74548117
34MP0008438_abnormal_cutaneous_collagen1.66439491
35MP0001845_abnormal_inflammatory_respons1.60019612
36MP0002398_abnormal_bone_marrow1.57781964
37MP0003566_abnormal_cell_adhesion1.57654133
38MP0000716_abnormal_immune_system1.56475488
39MP0009278_abnormal_bone_marrow1.54559273
40MP0005058_abnormal_lysosome_morphology1.53529005
41MP0002138_abnormal_hepatobiliary_system1.52773340
42MP0002254_reproductive_system_inflammat1.52395513
43MP0004264_abnormal_extraembryonic_tissu1.49116950
44MP0003866_abnormal_defecation1.43577567
45MP0009764_decreased_sensitivity_to1.42282579
46MP0003191_abnormal_cellular_cholesterol1.40712797
47MP0001533_abnormal_skeleton_physiology1.40493649
48MP0009840_abnormal_foam_cell1.40019550
49MP0008469_abnormal_protein_level1.38864369
50MP0003828_pulmonary_edema1.34903183
51MP0000689_abnormal_spleen_morphology1.32681724
52MP0005310_abnormal_salivary_gland1.30846234
53MP0001545_abnormal_hematopoietic_system1.30661085
54MP0005397_hematopoietic_system_phenotyp1.30661085
55MP0005164_abnormal_response_to1.29639565
56MP0003448_altered_tumor_morphology1.28677613
57MP0002722_abnormal_immune_system1.28407298
58MP0009333_abnormal_splenocyte_physiolog1.28076557
59MP0002429_abnormal_blood_cell1.26315740
60MP0003045_fibrosis1.23025067
61MP0000343_altered_response_to1.22190908
62MP0004883_abnormal_blood_vessel1.22146993
63MP0002139_abnormal_hepatobiliary_system1.20198935
64MP0004808_abnormal_hematopoietic_stem1.17963691
65MP0010352_gastrointestinal_tract_polyps1.14516633
66MP0005360_urolithiasis1.13790380
67MP0002396_abnormal_hematopoietic_system1.12942472
68MP0003656_abnormal_erythrocyte_physiolo1.12825834
69MP0000569_abnormal_digit_pigmentation1.10954756
70MP0008004_abnormal_stomach_pH1.10654272
71MP0002933_joint_inflammation1.08923579
72MP0002998_abnormal_bone_remodeling1.08596362
73MP0000858_altered_metastatic_potential1.07373967
74MP0003453_abnormal_keratinocyte_physiol1.07240956
75MP0005409_darkened_coat_color1.05790637
76MP0003252_abnormal_bile_duct1.05156380
77MP0003183_abnormal_peptide_metabolism1.04006374
78MP0005076_abnormal_cell_differentiation1.03664371
79MP0005023_abnormal_wound_healing0.99816796
80MP0003172_abnormal_lysosome_physiology0.99267264
81MP0003705_abnormal_hypodermis_morpholog0.99227632
82MP0004272_abnormal_basement_membrane0.97917564
83MP0003091_abnormal_cell_migration0.97751680
84MP0000465_gastrointestinal_hemorrhage0.95590582
85MP0000703_abnormal_thymus_morphology0.94878899
86MP0003950_abnormal_plasma_membrane0.92872150
87MP0001915_intracranial_hemorrhage0.92762328
88MP0001849_ear_inflammation0.92547887
89MP0000609_abnormal_liver_physiology0.92220173
90MP0009763_increased_sensitivity_to0.91092017
91MP0004185_abnormal_adipocyte_glucose0.88785355
92MP0005621_abnormal_cell_physiology0.88221536
93MP0001879_abnormal_lymphatic_vessel0.88043448
94MP0000767_abnormal_smooth_muscle0.86904029
95MP0003075_altered_response_to0.86808384
96MP0000249_abnormal_blood_vessel0.86532628
97MP0002136_abnormal_kidney_physiology0.86530073
98MP0008057_abnormal_DNA_replication0.84998433
99MP0000490_abnormal_crypts_of0.84661067
100MP0001851_eye_inflammation0.82981047
101MP0005165_increased_susceptibility_to0.82508610
102MP0002877_abnormal_melanocyte_morpholog0.81536766
103MP0003279_aneurysm0.79691409
104MP0000604_amyloidosis0.78754200
105MP0002009_preneoplasia0.77357723
106MP0005670_abnormal_white_adipose0.76025462
107MP0009643_abnormal_urine_homeostasis0.74678401
108MP0005174_abnormal_tail_pigmentation0.73009825
109MP0005166_decreased_susceptibility_to0.72701266
110MP0004130_abnormal_muscle_cell0.71820093
111MP0010630_abnormal_cardiac_muscle0.70674874
112MP0004084_abnormal_cardiac_muscle0.70604471
113MP0005365_abnormal_bile_salt0.70601816
114MP0002060_abnormal_skin_morphology0.69916340
115MP0010307_abnormal_tumor_latency0.69639181
116MP0005167_abnormal_blood-brain_barrier0.66988165
117MP0001666_abnormal_nutrient_absorption0.66136802
118MP0001663_abnormal_digestive_system0.65001770
119MP0001958_emphysema0.64459387
120MP0005390_skeleton_phenotype0.63857423
121MP0006054_spinal_hemorrhage0.63411975

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.72849580
2Autoimmune thrombocytopenia (HP:0001973)4.54901527
3Recurrent abscess formation (HP:0002722)4.35223848
4Recurrent bacterial skin infections (HP:0005406)4.22967814
5Recurrent fungal infections (HP:0002841)3.95085667
6Recurrent viral infections (HP:0004429)3.63438084
7Myositis (HP:0100614)3.55555806
8Recurrent gram-negative bacterial infections (HP:0005420)3.32170957
9Pustule (HP:0200039)3.23904900
10Orchitis (HP:0100796)3.23123424
11Vasculitis (HP:0002633)3.20469665
12Recurrent skin infections (HP:0001581)3.17601028
13Colitis (HP:0002583)3.16153720
14Spontaneous hematomas (HP:0007420)3.15229025
15Abnormality of macrophages (HP:0004311)3.12232039
16Elevated erythrocyte sedimentation rate (HP:0003565)3.08580222
17Mediastinal lymphadenopathy (HP:0100721)3.06658616
18Inflammation of the large intestine (HP:0002037)3.05524278
19Abnormality of the fingertips (HP:0001211)3.00638182
20Chronic otitis media (HP:0000389)2.98087137
21Retrobulbar optic neuritis (HP:0100654)2.97851333
22Optic neuritis (HP:0100653)2.97851333
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.97275301
24Myocardial infarction (HP:0001658)2.96324636
25Hematochezia (HP:0002573)2.94561063
26Chronic mucocutaneous candidiasis (HP:0002728)2.94252007
27Recurrent cutaneous fungal infections (HP:0011370)2.94252007
28Stomatitis (HP:0010280)2.90735204
29Abnormality of T cell number (HP:0011839)2.90669505
30Gingivitis (HP:0000230)2.86199815
31Gingival bleeding (HP:0000225)2.84346293
32T lymphocytopenia (HP:0005403)2.83580743
33Gastrointestinal inflammation (HP:0004386)2.81265412
34Interstitial pulmonary disease (HP:0006530)2.80259732
35Increased IgE level (HP:0003212)2.78361705
36Periodontitis (HP:0000704)2.78302840
37Arterial thrombosis (HP:0004420)2.72407360
38Flat acetabular roof (HP:0003180)2.70375420
39Abnormality of the nasal mucosa (HP:0000433)2.66908820
40Subacute progressive viral hepatitis (HP:0006572)2.65862121
41Cellulitis (HP:0100658)2.62121253
42Meningitis (HP:0001287)2.59922340
43Abnormality of T cells (HP:0002843)2.58496524
44IgM deficiency (HP:0002850)2.54399632
45Recurrent bronchitis (HP:0002837)2.52285438
46Chronic diarrhea (HP:0002028)2.51771438
47Nasal polyposis (HP:0100582)2.49133668
48Agammaglobulinemia (HP:0004432)2.48195044
49Spondylolisthesis (HP:0003302)2.47338153
50Pulmonary infiltrates (HP:0002113)2.45569196
51Abnormality of T cell physiology (HP:0011840)2.44942419
52Esophageal varix (HP:0002040)2.43339604
53Viral hepatitis (HP:0006562)2.38731821
54Leukocytosis (HP:0001974)2.38310656
55Abnormality of glycolipid metabolism (HP:0010969)2.35478895
56Abnormality of liposaccharide metabolism (HP:0010968)2.35478895
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.35478895
58Gastrointestinal stroma tumor (HP:0100723)2.34960774
59IgA deficiency (HP:0002720)2.33896982
60Thyroiditis (HP:0100646)2.33746753
61Protrusio acetabuli (HP:0003179)2.32915011
62Panhypogammaglobulinemia (HP:0003139)2.32760492
63Obstructive lung disease (HP:0006536)2.32637367
64Chronic obstructive pulmonary disease (HP:0006510)2.32637367
65Vertebral compression fractures (HP:0002953)2.31919206
66Vacuolated lymphocytes (HP:0001922)2.31375648
67Autoimmune hemolytic anemia (HP:0001890)2.31326216
68Eosinophilia (HP:0001880)2.31089659
69Hemoptysis (HP:0002105)2.30959087
70Arterial tortuosity (HP:0005116)2.30906629
71Epistaxis (HP:0000421)2.30254270
72Gastrointestinal infarctions (HP:0005244)2.28792902
73Osteolytic defects of the hand bones (HP:0009699)2.28067861
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.28067861
75Hemorrhage of the eye (HP:0011885)2.25780202
76Osteomyelitis (HP:0002754)2.25643351
77Broad face (HP:0000283)2.24370886
78Prolonged bleeding time (HP:0003010)2.22146928
79Severe combined immunodeficiency (HP:0004430)2.14692905
80Right ventricular cardiomyopathy (HP:0011663)2.14689347
81Vascular tortuosity (HP:0004948)2.13764394
82Increased IgM level (HP:0003496)2.12479435
83Abnormal platelet volume (HP:0011876)2.11773556
84Keratoconjunctivitis sicca (HP:0001097)2.10127674
85Emphysema (HP:0002097)2.09910770
86Polycythemia (HP:0001901)2.09854836
87Abnormality of eosinophils (HP:0001879)2.09282749
88Lymphopenia (HP:0001888)2.08798946
89Chest pain (HP:0100749)2.07688787
90Spinal cord lesions (HP:0100561)2.06488122
91Syringomyelia (HP:0003396)2.06488122
92Pulmonary embolism (HP:0002204)2.06357926
93Hypergammaglobulinemia (HP:0010702)2.05992570
94Keratoconjunctivitis (HP:0001096)2.05506160
95Combined immunodeficiency (HP:0005387)2.04356848
96Aortic aneurysm (HP:0004942)2.04281338
97Nephritis (HP:0000123)2.03345548
98Abnormality of cells of the lymphoid lineage (HP:0012140)2.02765403
99Cervical subluxation (HP:0003308)2.02557466
100Increased cerebral lipofuscin (HP:0011813)1.99756079
101Dysostosis multiplex (HP:0000943)1.99690966
102Joint swelling (HP:0001386)1.98579272
103Premature rupture of membranes (HP:0001788)1.98462802
104Dilatation of the ascending aorta (HP:0005111)1.97799363
105B lymphocytopenia (HP:0010976)1.97256132
106Abnormality of B cell number (HP:0010975)1.97256132
107Systemic lupus erythematosus (HP:0002725)1.96969857
108Peritonitis (HP:0002586)1.96928139
109Amyloidosis (HP:0011034)1.95331633
110Impaired platelet aggregation (HP:0003540)1.93408539
111Abnormal platelet function (HP:0011869)1.93408539
112Encephalitis (HP:0002383)1.93343714
113Restrictive lung disease (HP:0002091)1.93336933
114Abnormality of oral frenula (HP:0000190)1.92976801
115Granulocytopenia (HP:0001913)1.92491238
116Tetraparesis (HP:0002273)1.91881790
117Urticaria (HP:0001025)1.89767072
118Aortic dissection (HP:0002647)1.89037015
119Skin ulcer (HP:0200042)1.89010010
120Thick nail (HP:0001805)1.88785855
121Loss of speech (HP:0002371)1.88760715
122Petechiae (HP:0000967)1.88632530
123Increased mean platelet volume (HP:0011877)1.87722544
124Mitral stenosis (HP:0001718)1.87540955
125Abnormality of the common coagulation pathway (HP:0010990)1.87392363
126Mucopolysacchariduria (HP:0008155)1.86397655
127Urinary glycosaminoglycan excretion (HP:0003541)1.86397655
128Increased neuronal autofluorescent lipopigment (HP:0002074)1.84979618
129Micronodular cirrhosis (HP:0001413)1.83427458
130Aneurysm (HP:0002617)1.82147633
131Ankyloglossia (HP:0010296)1.81103090
132Fatigue (HP:0012378)1.77696561
133Abnormality of the peritoneum (HP:0002585)1.77434471
134Wormian bones (HP:0002645)1.77342049
135Absent frontal sinuses (HP:0002688)1.76219904
136Glucose intolerance (HP:0000833)1.75465429
137Deep venous thrombosis (HP:0002625)1.75054338
138Malnutrition (HP:0004395)1.74502934
139Abnormality of complement system (HP:0005339)1.74498317
140Cerebral aneurysm (HP:0004944)1.72908215
141Abnormal glucose tolerance (HP:0001952)1.72613319
142Short nail (HP:0001799)1.72424063
143Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71432351
144Abnormality of polysaccharide metabolism (HP:0011012)1.71432351
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71432351
146Thin bony cortex (HP:0002753)1.71117814
147Coarse hair (HP:0002208)1.70076241
148Abnormality of monocarboxylic acid metabolism (HP:0010996)1.68162140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.51476857
2MAP3K143.16984981
3TXK2.79847205
4TYK22.77424995
5PRPF4B2.63343475
6JAK32.62262821
7IRAK32.51858083
8TBK12.47973730
9JAK12.46718294
10IKBKE2.33522468
11ERN12.31609294
12IRAK42.15978057
13EPHB12.12378895
14FGFR42.08834534
15TAOK31.95413227
16TGFBR21.92549929
17SMG11.90510650
18STK101.88645743
19EPHA21.79591429
20IKBKB1.77744561
21ZAP701.76936183
22FGFR31.74975197
23BLK1.74879826
24SCYL21.67541562
25MST41.64930042
26CDK121.60526344
27TTN1.56674943
28CHUK1.53308592
29KIT1.52615555
30ITK1.51980838
31CSK1.43934210
32LMTK21.39062228
33MAP3K131.38396367
34PDGFRA1.37043053
35BTK1.35682081
36TEC1.35492633
37MET1.32578175
38TRIB31.29500422
39PTK61.28789719
40BMPR21.28530837
41MAP3K101.28124145
42RIPK41.27004282
43TRPM71.25732250
44ICK1.23793880
45NEK91.23144136
46SIK11.22819672
47PAK41.21512188
48CAMK1D1.18500342
49EPHA31.17007632
50HCK1.14534812
51LRRK21.14251138
52MAP2K31.14194008
53JAK21.09801254
54FGR1.07786877
55LCK1.07742217
56SYK1.07677641
57PIM11.05942191
58CSF1R1.05246526
59MELK1.01524104
60YES11.01506773
61NLK1.01458809
62RPS6KA41.01012129
63MAP3K21.00263364
64PKN20.93249062
65RIPK10.92142746
66MAP3K10.91395655
67DMPK0.88457249
68STK40.85213513
69MARK30.84708957
70GRK60.84680609
71MAP3K70.83828103
72CDC42BPA0.83063704
73CAMK1G0.74467567
74KDR0.71018691
75PIK3CG0.70981027
76PRKCQ0.70476637
77TIE10.69898056
78KSR20.69896041
79MAP3K60.68686363
80NME20.68120818
81CDK40.67544523
82PRKG20.66731408
83LYN0.64388025
84PRKAA20.62435416
85EEF2K0.62196551
86MAP3K80.61505830
87WNK10.61125294
88FLT30.60774280
89PIK3CA0.60677196
90PDGFRB0.60353441
91PIM20.60321278
92IRAK10.59590478
93MATK0.59571199
94BMX0.58966086
95PRKD20.58889328
96STK240.58434947
97FRK0.57106826
98RPS6KB20.55808063
99STK30.55770410
100CDK60.55106583
101RET0.54770831
102TESK20.54226805
103NUAK10.54177322
104STK380.54122577
105CDK90.53195289
106MAPKAPK20.52309956
107ABL10.51769416
108SIK20.49191615
109MARK20.48397383
110MAP3K30.47775202
111PDK10.46093647
112EGFR0.45848658
113NEK60.45306632
114MOS0.45161414
115HIPK20.44716261
116MAPK70.43604431
117RPS6KA60.42043347
118MYLK0.41207230
119SGK30.40741548
120MAPK110.39269461
121PRKD10.35623177
122BRD40.35195303
123MTOR0.32923974
124CLK10.32467657
125FES0.32427527
126SIK30.32249384
127PDPK10.32045165
128PRKCH0.31389896
129OBSCN0.30904086
130PTK20.30764407
131MAPK120.30178026
132MST1R0.30169911

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.70388321
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.66527121
3Primary immunodeficiency_Homo sapiens_hsa053402.65832419
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.36163242
5Caffeine metabolism_Homo sapiens_hsa002322.35319828
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29891420
7Staphylococcus aureus infection_Homo sapiens_hsa051502.22680162
8Osteoclast differentiation_Homo sapiens_hsa043802.19228316
9Allograft rejection_Homo sapiens_hsa053302.11870337
10Measles_Homo sapiens_hsa051622.10537092
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01782731
12B cell receptor signaling pathway_Homo sapiens_hsa046621.97417022
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94883186
14Toxoplasmosis_Homo sapiens_hsa051451.84806238
15Graft-versus-host disease_Homo sapiens_hsa053321.81022254
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80782236
17Hematopoietic cell lineage_Homo sapiens_hsa046401.74027592
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.67513820
19TNF signaling pathway_Homo sapiens_hsa046681.63461651
20Malaria_Homo sapiens_hsa051441.53701151
21Viral myocarditis_Homo sapiens_hsa054161.53007119
22Influenza A_Homo sapiens_hsa051641.49355628
23Antigen processing and presentation_Homo sapiens_hsa046121.44871428
24Non-small cell lung cancer_Homo sapiens_hsa052231.44044508
25T cell receptor signaling pathway_Homo sapiens_hsa046601.41320988
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.38145450
27Tuberculosis_Homo sapiens_hsa051521.38109409
28Pertussis_Homo sapiens_hsa051331.37934683
29Herpes simplex infection_Homo sapiens_hsa051681.35604684
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33305288
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32527361
32Autoimmune thyroid disease_Homo sapiens_hsa053201.30326603
33Legionellosis_Homo sapiens_hsa051341.26521007
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26328441
35Asthma_Homo sapiens_hsa053101.22907016
36Thyroid cancer_Homo sapiens_hsa052161.19402002
37* Apoptosis_Homo sapiens_hsa042101.17316472
38Chemokine signaling pathway_Homo sapiens_hsa040621.17257751
39Acute myeloid leukemia_Homo sapiens_hsa052211.17162976
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16014168
41Hepatitis C_Homo sapiens_hsa051601.14944674
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13805632
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13267281
44Small cell lung cancer_Homo sapiens_hsa052221.08026387
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08003569
46Hepatitis B_Homo sapiens_hsa051611.05606578
47Insulin resistance_Homo sapiens_hsa049311.04608854
48Shigellosis_Homo sapiens_hsa051311.02147719
49Platelet activation_Homo sapiens_hsa046111.01103637
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.98439258
51Salmonella infection_Homo sapiens_hsa051320.98290590
52Chronic myeloid leukemia_Homo sapiens_hsa052200.96886891
53Complement and coagulation cascades_Homo sapiens_hsa046100.96564589
54Renal cell carcinoma_Homo sapiens_hsa052110.94361928
55Amoebiasis_Homo sapiens_hsa051460.93206907
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92353279
57ABC transporters_Homo sapiens_hsa020100.91925583
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.90341972
59Prolactin signaling pathway_Homo sapiens_hsa049170.88569863
60Endometrial cancer_Homo sapiens_hsa052130.88371376
61Bladder cancer_Homo sapiens_hsa052190.87580037
62Lysosome_Homo sapiens_hsa041420.81313645
63Galactose metabolism_Homo sapiens_hsa000520.80697144
64Lysine degradation_Homo sapiens_hsa003100.80046469
65Pancreatic cancer_Homo sapiens_hsa052120.78642604
66Rheumatoid arthritis_Homo sapiens_hsa053230.76111435
67Pentose phosphate pathway_Homo sapiens_hsa000300.75858027
68African trypanosomiasis_Homo sapiens_hsa051430.74857944
69Other glycan degradation_Homo sapiens_hsa005110.72949897
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72607884
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71776446
72PPAR signaling pathway_Homo sapiens_hsa033200.70693965
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.70569350
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69426849
75Inositol phosphate metabolism_Homo sapiens_hsa005620.68070074
76Focal adhesion_Homo sapiens_hsa045100.65685059
77Starch and sucrose metabolism_Homo sapiens_hsa005000.64986449
78Renin-angiotensin system_Homo sapiens_hsa046140.63232286
79Fatty acid degradation_Homo sapiens_hsa000710.62083316
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61881062
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61312401
82mTOR signaling pathway_Homo sapiens_hsa041500.61153480
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61152661
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.61050375
85Tryptophan metabolism_Homo sapiens_hsa003800.60596108
86Colorectal cancer_Homo sapiens_hsa052100.59759320
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.59660500
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58546453
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58176240
90Fructose and mannose metabolism_Homo sapiens_hsa000510.57929233
91Endocytosis_Homo sapiens_hsa041440.57461399
92Choline metabolism in cancer_Homo sapiens_hsa052310.56814742
93Proteoglycans in cancer_Homo sapiens_hsa052050.56679328
94Notch signaling pathway_Homo sapiens_hsa043300.54915872
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53278063
96ECM-receptor interaction_Homo sapiens_hsa045120.52995440
97Adherens junction_Homo sapiens_hsa045200.52883532
98Histidine metabolism_Homo sapiens_hsa003400.52662379
99Epstein-Barr virus infection_Homo sapiens_hsa051690.52298092
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51033711
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50940624
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50779896
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50725308
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.49163277
105FoxO signaling pathway_Homo sapiens_hsa040680.48695372
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48105610
107Type I diabetes mellitus_Homo sapiens_hsa049400.48062169
108Dorso-ventral axis formation_Homo sapiens_hsa043200.46755738
109HTLV-I infection_Homo sapiens_hsa051660.45412160
110Vitamin digestion and absorption_Homo sapiens_hsa049770.43948333
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41681793
112HIF-1 signaling pathway_Homo sapiens_hsa040660.41239949
113Type II diabetes mellitus_Homo sapiens_hsa049300.39572270
114Fat digestion and absorption_Homo sapiens_hsa049750.39370821
115VEGF signaling pathway_Homo sapiens_hsa043700.38880888
116Phagosome_Homo sapiens_hsa041450.38876334
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38192335
118Viral carcinogenesis_Homo sapiens_hsa052030.36687108
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.35551262
120MicroRNAs in cancer_Homo sapiens_hsa052060.35432321
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34722055
122Prostate cancer_Homo sapiens_hsa052150.34004625

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