PARP4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)8.64030930
2platelet dense granule organization (GO:0060155)7.86755977
3cellular response to interleukin-15 (GO:0071350)6.37649168
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.65099316
5negative regulation of cell killing (GO:0031342)5.56738498
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.56738498
7regulation of memory T cell differentiation (GO:0043380)5.37317046
8positive regulation of defense response to virus by host (GO:0002230)5.35686118
9DNA deamination (GO:0045006)5.21810833
10regulation of activation of Janus kinase activity (GO:0010533)4.92819014
11DNA damage response, detection of DNA damage (GO:0042769)4.69576243
12hair cycle (GO:0042633)4.56925374
13molting cycle (GO:0042303)4.56925374
14L-fucose catabolic process (GO:0042355)4.53392174
15fucose catabolic process (GO:0019317)4.53392174
16L-fucose metabolic process (GO:0042354)4.53392174
17response to interleukin-15 (GO:0070672)4.37578264
18positive regulation of interleukin-8 secretion (GO:2000484)4.37269229
19sequestering of actin monomers (GO:0042989)4.23968630
20positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.17762674
21valine metabolic process (GO:0006573)4.16820762
22positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.15819132
23regulation of interleukin-8 secretion (GO:2000482)4.07736877
24regulation of leukocyte mediated cytotoxicity (GO:0001910)4.07044199
25endothelial tube morphogenesis (GO:0061154)4.06566427
26morphogenesis of an endothelium (GO:0003159)4.06566427
27GTP biosynthetic process (GO:0006183)4.03075671
28negative regulation of telomere maintenance (GO:0032205)4.03018756
29interferon-gamma production (GO:0032609)3.99166561
30regulation of T cell mediated cytotoxicity (GO:0001914)3.93836670
31positive regulation of cell fate commitment (GO:0010455)3.93708268
32positive regulation of interleukin-17 production (GO:0032740)3.79518937
33regulation of telomere maintenance via telomerase (GO:0032210)3.78585164
34negative regulation of NF-kappaB import into nucleus (GO:0042347)3.78009962
35regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.76060071
36sulfation (GO:0051923)3.72382119
37nucleotide transmembrane transport (GO:1901679)3.71125908
38UTP metabolic process (GO:0046051)3.70563721
39cytidine metabolic process (GO:0046087)3.68364397
40cytidine catabolic process (GO:0006216)3.68364397
41cytidine deamination (GO:0009972)3.68364397
42regulation of defense response to virus by host (GO:0050691)3.62287729
43positive regulation of T cell mediated cytotoxicity (GO:0001916)3.62159576
44regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.57294591
45regulation of natural killer cell mediated immunity (GO:0002715)3.57294591
46secretory granule organization (GO:0033363)3.55450370
47adenine nucleotide transport (GO:0051503)3.49521927
48UTP biosynthetic process (GO:0006228)3.48701472
49regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.48015545
50regulation of cell killing (GO:0031341)3.47541297
51natural killer cell activation (GO:0030101)3.39415307
52behavioral response to nicotine (GO:0035095)3.35374744
53branched-chain amino acid catabolic process (GO:0009083)3.34943443
54purine ribonucleotide transport (GO:0015868)3.30849757
55regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.29326190
56positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.28352718
57positive regulation of T-helper 1 type immune response (GO:0002827)3.25355661
58negative regulation of interleukin-10 production (GO:0032693)3.23169396
59mitochondrial DNA replication (GO:0006264)3.22672884
60response to redox state (GO:0051775)3.15721170
61pericardium development (GO:0060039)3.14798996
62lymph node development (GO:0048535)3.05158162
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00338474
64fucose metabolic process (GO:0006004)2.99959103
65protein neddylation (GO:0045116)2.97108682
66dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.95567808
67pyrimidine ribonucleoside catabolic process (GO:0046133)2.94355772
68regulation of telomere maintenance (GO:0032204)2.92902775
69lipopolysaccharide biosynthetic process (GO:0009103)2.91572861
70behavioral response to ethanol (GO:0048149)2.91503272
71multicellular organism reproduction (GO:0032504)2.85567193
72anterograde synaptic vesicle transport (GO:0048490)2.84964076
73muscle organ morphogenesis (GO:0048644)2.84213550
74positive regulation of cell killing (GO:0031343)2.80936932
75negative regulation of T cell mediated immunity (GO:0002710)2.80764020
76positive regulation of cell cycle G2/M phase transition (GO:1902751)2.76323760
77positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.76323760
78branched-chain amino acid metabolic process (GO:0009081)2.73685558
79tumor necrosis factor-mediated signaling pathway (GO:0033209)2.71094703
80regulation of cell fate commitment (GO:0010453)2.69068099
81mannosylation (GO:0097502)2.67911210
82guanosine-containing compound biosynthetic process (GO:1901070)2.67813105
83metallo-sulfur cluster assembly (GO:0031163)2.66717825
84iron-sulfur cluster assembly (GO:0016226)2.66717825
85positive regulation of natural killer cell mediated immunity (GO:0002717)2.66218234
86regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.64248770
87kynurenine metabolic process (GO:0070189)2.62137398
88intra-S DNA damage checkpoint (GO:0031573)2.61949453
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61724129
903-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.61679581
91purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.61679581
92positive regulation of uterine smooth muscle contraction (GO:0070474)2.61260655
93positive regulation of T cell differentiation in thymus (GO:0033089)2.60231358
94nucleoside transmembrane transport (GO:1901642)2.59567843
95positive regulation of actin cytoskeleton reorganization (GO:2000251)2.59057062
96ubiquinone biosynthetic process (GO:0006744)2.58794920
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.57864430
98negative regulation of ligase activity (GO:0051352)2.57261076
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57261076
100purine nucleotide transport (GO:0015865)2.56769400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27500549
2VDR_22108803_ChIP-Seq_LS180_Human3.96711972
3NOTCH1_21737748_ChIP-Seq_TLL_Human3.08354093
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.80768800
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.65120741
6VDR_23849224_ChIP-Seq_CD4+_Human2.64958397
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61376329
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.55711918
9E2F7_22180533_ChIP-Seq_HELA_Human2.50636091
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33968458
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.33437530
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31604706
13IRF1_19129219_ChIP-ChIP_H3396_Human2.26530059
14ZNF274_21170338_ChIP-Seq_K562_Hela2.25083463
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.23343032
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18636705
17FOXP3_21729870_ChIP-Seq_TREG_Human2.17166754
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.16476530
19PADI4_21655091_ChIP-ChIP_MCF-7_Human2.15938118
20IGF1R_20145208_ChIP-Seq_DFB_Human2.15829187
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.13350952
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.09395688
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00473850
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99216239
25TAF15_26573619_Chip-Seq_HEK293_Human1.98321188
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95746612
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78397590
28EWS_26573619_Chip-Seq_HEK293_Human1.67004611
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66877533
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65757220
31FOXA1_21572438_ChIP-Seq_LNCaP_Human1.55004970
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52555313
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51798207
34TP53_22573176_ChIP-Seq_HFKS_Human1.49690698
35RUNX_20019798_ChIP-Seq_JUKART_Human1.49521543
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49250412
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.46107139
38STAT1_20625510_ChIP-Seq_HELA_Human1.45738439
39MYC_18940864_ChIP-ChIP_HL60_Human1.44732822
40AR_20517297_ChIP-Seq_VCAP_Human1.41395895
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40552331
42ER_23166858_ChIP-Seq_MCF-7_Human1.39415639
43GATA1_22025678_ChIP-Seq_K562_Human1.39321055
44NCOR_22424771_ChIP-Seq_293T_Human1.38392250
45GATA3_26560356_Chip-Seq_TH1_Human1.38254206
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37508629
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35631629
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33107754
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33049312
50FUS_26573619_Chip-Seq_HEK293_Human1.32571090
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27965136
52ELK1_19687146_ChIP-ChIP_HELA_Human1.27389236
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.26460037
54GATA3_26560356_Chip-Seq_TH2_Human1.25252000
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22948918
56FOXH1_21741376_ChIP-Seq_EPCs_Human1.22071365
57LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20463621
58TTF2_22483619_ChIP-Seq_HELA_Human1.20461705
59DCP1A_22483619_ChIP-Seq_HELA_Human1.19287683
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.18467609
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16622552
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12551472
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.12551472
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12165991
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11696230
66GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10135329
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08506819
68CBP_20019798_ChIP-Seq_JUKART_Human1.08506819
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06638777
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05970086
71AR_21572438_ChIP-Seq_LNCaP_Human1.05207023
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02515266
73P300_19829295_ChIP-Seq_ESCs_Human1.02091957
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.00736519
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00571635
76PHF8_20622853_ChIP-Seq_HELA_Human1.00304837
77AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99763181
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98811007
79GATA6_21074721_ChIP-Seq_CACO-2_Human0.97804514
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97599839
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97092975
82RBPJ_21746931_ChIP-Seq_IB4_Human0.96903273
83BCAT_22108803_ChIP-Seq_LS180_Human0.96626770
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96225789
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95733396
86HOXB7_26014856_ChIP-Seq_BT474_Human0.95128196
87HNFA_21074721_ChIP-Seq_CACO-2_Human0.95085485
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.94795147
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94384915
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92692914
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92672225
92NFYB_21822215_ChIP-Seq_K562_Human0.92377236
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91187745
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.90864056
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90640771
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.90528780
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90498420
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90433014
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88678426
100MYB_26560356_Chip-Seq_TH2_Human0.86795286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot4.36423853
2MP0003878_abnormal_ear_physiology4.36423853
3MP0003195_calcinosis4.26503188
4MP0003941_abnormal_skin_development3.84115606
5MP0006292_abnormal_olfactory_placode3.36592928
6MP0005671_abnormal_response_to3.26196823
7MP0006072_abnormal_retinal_apoptosis2.64907071
8MP0003787_abnormal_imprinting2.62693544
9MP0008877_abnormal_DNA_methylation2.48904102
10MP0002736_abnormal_nociception_after2.27173744
11MP0001529_abnormal_vocalization2.20861033
12MP0009785_altered_susceptibility_to2.14109843
13MP0005253_abnormal_eye_physiology1.96350066
14MP0003724_increased_susceptibility_to1.84551321
15MP0000427_abnormal_hair_cycle1.80476462
16MP0004147_increased_porphyrin_level1.76446997
17MP0009764_decreased_sensitivity_to1.70425865
18MP0010386_abnormal_urinary_bladder1.69952953
19MP0001968_abnormal_touch/_nociception1.68621906
20MP0000685_abnormal_immune_system1.66954242
21MP0005551_abnormal_eye_electrophysiolog1.61115157
22MP0003786_premature_aging1.60615543
23MP0002277_abnormal_respiratory_mucosa1.59995604
24MP0005084_abnormal_gallbladder_morpholo1.59233390
25MP0010094_abnormal_chromosome_stability1.49270074
26MP0003693_abnormal_embryo_hatching1.47776561
27MP0009765_abnormal_xenobiotic_induced1.47574891
28MP0005174_abnormal_tail_pigmentation1.47537695
29MP0001501_abnormal_sleep_pattern1.44074203
30MP0008007_abnormal_cellular_replicative1.42165657
31MP0000465_gastrointestinal_hemorrhage1.41500867
32MP0002928_abnormal_bile_duct1.41120508
33MP0003111_abnormal_nucleus_morphology1.40549817
34MP0004381_abnormal_hair_follicle1.40498333
35MP0003011_delayed_dark_adaptation1.33460946
36MP0005000_abnormal_immune_tolerance1.31847233
37MP0002876_abnormal_thyroid_physiology1.28106802
38MP0000358_abnormal_cell_content/1.26878352
39MP0001835_abnormal_antigen_presentation1.25071227
40MP0001324_abnormal_eye_pigmentation1.24975561
41MP0005085_abnormal_gallbladder_physiolo1.22547577
42MP0004947_skin_inflammation1.20931151
43MP0002102_abnormal_ear_morphology1.19589913
44MP0000647_abnormal_sebaceous_gland1.17916545
45MP0001243_abnormal_dermal_layer1.17523082
46MP0003567_abnormal_fetal_cardiomyocyte1.17064253
47MP0002075_abnormal_coat/hair_pigmentati1.09459798
48MP0005389_reproductive_system_phenotype1.09142627
49MP0004133_heterotaxia1.07830652
50MP0002723_abnormal_immune_serum1.07292329
51MP0008932_abnormal_embryonic_tissue1.06710912
52MP0003828_pulmonary_edema1.06112091
53MP0002148_abnormal_hypersensitivity_rea1.05837221
54MP0001986_abnormal_taste_sensitivity1.05069741
55MP0005025_abnormal_response_to1.04304583
56MP0001819_abnormal_immune_cell1.03730429
57MP0002420_abnormal_adaptive_immunity1.01659814
58MP0001293_anophthalmia1.00600298
59MP0001764_abnormal_homeostasis1.00420435
60MP0005075_abnormal_melanosome_morpholog0.99528468
61MP0003866_abnormal_defecation0.98061348
62MP0008469_abnormal_protein_level0.97337825
63MP0001851_eye_inflammation0.96484583
64MP0006035_abnormal_mitochondrial_morpho0.96218616
65MP0004885_abnormal_endolymph0.96109094
66MP0005386_behavior/neurological_phenoty0.95805343
67MP0004924_abnormal_behavior0.95805343
68MP0002006_tumorigenesis0.95738755
69MP0002638_abnormal_pupillary_reflex0.93976853
70MP0002933_joint_inflammation0.91128361
71MP0001485_abnormal_pinna_reflex0.90551357
72MP0000371_diluted_coat_color0.90440992
73MP0001661_extended_life_span0.90416971
74MP0005332_abnormal_amino_acid0.87160743
75MP0010155_abnormal_intestine_physiology0.86427398
76MP0001800_abnormal_humoral_immune0.85548939
77MP0005319_abnormal_enzyme/_coenzyme0.83340497
78MP0002735_abnormal_chemical_nociception0.81133710
79MP0003121_genomic_imprinting0.80661301
80MP0001666_abnormal_nutrient_absorption0.80354869
81MP0003252_abnormal_bile_duct0.79881054
82MP0003718_maternal_effect0.77798903
83MP0000538_abnormal_urinary_bladder0.77640328
84MP0002452_abnormal_antigen_presenting0.77049750
85MP0000689_abnormal_spleen_morphology0.76260688
86MP0002398_abnormal_bone_marrow0.75961811
87MP0009763_increased_sensitivity_to0.75928357
88MP0002722_abnormal_immune_system0.75112310
89MP0002234_abnormal_pharynx_morphology0.73957746
90MP0002009_preneoplasia0.73049909
91MP0008058_abnormal_DNA_repair0.72030113
92MP0000716_abnormal_immune_system0.71877658
93MP0005197_abnormal_uvea_morphology0.71738329
94MP0002139_abnormal_hepatobiliary_system0.71514289
95MP0001790_abnormal_immune_system0.71112599
96MP0005387_immune_system_phenotype0.71112599
97MP0000703_abnormal_thymus_morphology0.70242715
98MP0002095_abnormal_skin_pigmentation0.70171854
99MP0003936_abnormal_reproductive_system0.69586726
100MP0001919_abnormal_reproductive_system0.68609546

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.74639653
2Optic neuritis (HP:0100653)4.74639653
3Severe combined immunodeficiency (HP:0004430)4.51095923
4Aplastic anemia (HP:0001915)4.38617105
5Brittle hair (HP:0002299)4.34733823
6Congenital, generalized hypertrichosis (HP:0004540)4.31235984
7Orchitis (HP:0100796)4.24194021
8Albinism (HP:0001022)4.23162301
9Short tibia (HP:0005736)4.18556349
10Myositis (HP:0100614)3.90626409
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.82662388
12Aplasia/Hypoplasia of the tibia (HP:0005772)3.62577776
13Combined immunodeficiency (HP:0005387)3.62176113
14Pancreatic cysts (HP:0001737)3.59807299
15Selective tooth agenesis (HP:0001592)3.46847478
16Congenital stationary night blindness (HP:0007642)3.25130657
17Keratoconjunctivitis sicca (HP:0001097)3.13181636
18True hermaphroditism (HP:0010459)3.12323237
19Thyroiditis (HP:0100646)3.12038162
20Fibular hypoplasia (HP:0003038)3.10318606
21Bile duct proliferation (HP:0001408)3.10169304
22Abnormal biliary tract physiology (HP:0012439)3.10169304
23Microretrognathia (HP:0000308)3.07402235
24Abnormal number of incisors (HP:0011064)2.97807636
25Renal cortical cysts (HP:0000803)2.94531139
26Keratoconjunctivitis (HP:0001096)2.92186922
27Aplasia/Hypoplasia of the fibula (HP:0006492)2.92130534
28Pancreatic fibrosis (HP:0100732)2.87883635
29Slow-growing hair (HP:0002217)2.87435100
30Abnormality of hair growth rate (HP:0011363)2.87435100
31Nonimmune hydrops fetalis (HP:0001790)2.80995591
32Abnormal pupillary function (HP:0007686)2.74946599
33Aplasia/hypoplasia of the uterus (HP:0008684)2.74946365
34Hypotrichosis (HP:0001006)2.65272043
35T lymphocytopenia (HP:0005403)2.63414566
36Abnormality of T cell number (HP:0011839)2.55334703
37Glossoptosis (HP:0000162)2.54994358
38IgG deficiency (HP:0004315)2.53338961
39Renal Fanconi syndrome (HP:0001994)2.52128542
40Large eyes (HP:0001090)2.52055619
41Chronic hepatic failure (HP:0100626)2.49600361
42Poor head control (HP:0002421)2.45503107
43Chronic bronchitis (HP:0004469)2.43865095
44Abnormality of eosinophils (HP:0001879)2.39194383
45Delayed CNS myelination (HP:0002188)2.38549926
46Hypoplasia of the uterus (HP:0000013)2.36483543
47Abnormality of the umbilical cord (HP:0010881)2.30546903
48Premature loss of primary teeth (HP:0006323)2.29017731
49Oral leukoplakia (HP:0002745)2.28759820
50Encephalitis (HP:0002383)2.26403601
51Type I transferrin isoform profile (HP:0003642)2.26041824
52Humeroradial synostosis (HP:0003041)2.25222408
53Synostosis involving the elbow (HP:0003938)2.25222408
54Stomach cancer (HP:0012126)2.23447084
55Fibular aplasia (HP:0002990)2.20730031
56Hemoptysis (HP:0002105)2.19510530
57Abnormality of macular pigmentation (HP:0008002)2.18536108
58Pancreatic islet-cell hyperplasia (HP:0004510)2.16832749
59Hyperglycinuria (HP:0003108)2.13577818
60Single umbilical artery (HP:0001195)2.13008271
61Abnormality of the fetal cardiovascular system (HP:0010948)2.13008271
62Abnormal umbilical cord blood vessels (HP:0011403)2.13008271
63Anhidrosis (HP:0000970)2.10709770
64Hypoproteinemia (HP:0003075)2.10266968
65Furrowed tongue (HP:0000221)2.06957140
66Abnormality of the renal cortex (HP:0011035)2.05172987
67Nephronophthisis (HP:0000090)2.05066856
68Severe visual impairment (HP:0001141)2.04012988
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.03046605
70Molar tooth sign on MRI (HP:0002419)2.02752005
71Abnormality of midbrain morphology (HP:0002418)2.02752005
72Occipital encephalocele (HP:0002085)2.02136478
73Stomatitis (HP:0010280)2.01617355
74Cystic liver disease (HP:0006706)2.00853457
75Rhinitis (HP:0012384)1.99124845
76Pancytopenia (HP:0001876)1.97483940
77Increased hepatocellular lipid droplets (HP:0006565)1.96823601
78Arterial thrombosis (HP:0004420)1.95221009
79Reduced subcutaneous adipose tissue (HP:0003758)1.91275174
803-Methylglutaconic aciduria (HP:0003535)1.86583994
81Exertional dyspnea (HP:0002875)1.84895953
82Potter facies (HP:0002009)1.83253739
83Facial shape deformation (HP:0011334)1.83253739
84Abnormal auditory evoked potentials (HP:0006958)1.82932706
85Hypoplasia of the fovea (HP:0007750)1.82644726
86Aplasia/Hypoplasia of the fovea (HP:0008060)1.82644726
87Pulmonary fibrosis (HP:0002206)1.79025357
88Absent speech (HP:0001344)1.78974911
89Hypochromic microcytic anemia (HP:0004840)1.78453422
90Gangrene (HP:0100758)1.78082783
91Abnormality of the fibula (HP:0002991)1.77264635
92Abnormality of the fovea (HP:0000493)1.76214408
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75206783
94Abnormality of the pons (HP:0007361)1.73822657
95Abnormal protein glycosylation (HP:0012346)1.72542738
96Abnormal glycosylation (HP:0012345)1.72542738
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72542738
98Abnormal protein N-linked glycosylation (HP:0012347)1.72542738
99Abnormality of the renal medulla (HP:0100957)1.71238905
100Abnormality of lateral ventricle (HP:0030047)1.70975889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.45999170
2TLK14.41515301
3SIK33.99389454
4ZAK2.85637232
5SRPK12.82019366
6FES2.73962883
7KDR2.73300620
8TIE12.46410786
9BUB12.21927359
10GRK12.11581590
11TESK22.09679051
12NME11.96119931
13NUAK11.95750345
14MKNK21.85871015
15LIMK11.83294049
16MUSK1.81760227
17MAP3K141.77996590
18STK101.74043243
19DYRK31.70537015
20INSRR1.63064605
21GRK61.56073393
22MST41.52910330
23RPS6KA41.47702095
24MKNK11.46869984
25TESK11.41169651
26SIK21.38005104
27BCR1.24624100
28BMPR1B1.15923058
29ADRBK21.07198495
30MAP4K11.06101065
31TGFBR11.02655061
32CDC71.00442214
33PLK30.99849653
34TAOK30.99842491
35TBK10.99017707
36MARK30.97157640
37IKBKE0.96122529
38TRIM280.93380198
39VRK10.91930202
40JAK10.87160998
41BCKDK0.86671399
42ERBB30.85922667
43TNIK0.83925276
44STK160.77343887
45LMTK20.75016071
46GRK70.74258186
47EIF2AK30.72645629
48KIT0.68796631
49NEK10.67379547
50JAK30.65473491
51MYLK0.65420816
52BMPR20.65340992
53TEC0.64856792
54TGFBR20.64520068
55SIK10.64467094
56PLK20.61069227
57CCNB10.61006343
58FRK0.60905711
59CHEK20.60831397
60IKBKB0.59516039
61ALK0.55438939
62EIF2AK20.54095407
63CSK0.52428526
64ROCK10.48541662
65CDK30.48516056
66ATR0.48070084
67LCK0.47316827
68ACVR1B0.47241798
69CSNK1G30.47003012
70TTK0.45870106
71WEE10.44935868
72PLK10.43936798
73HCK0.41383843
74FER0.41377574
75PRKCE0.41305133
76MAP3K80.41081066
77IGF1R0.40001765
78VRK20.39938921
79ABL10.38418174
80CHUK0.37996763
81CSNK1A1L0.37627466
82LYN0.37140218
83ERBB40.36880483
84MAPKAPK20.36348671
85IRAK30.35713004
86SYK0.35388586
87PRKCQ0.34227847
88PBK0.33342899
89PASK0.33230428
90MAPKAPK30.32967866
91ROCK20.32113558
92ATM0.31738860
93PIK3CA0.31618590
94WNK30.30188699
95MET0.30061492
96AURKB0.29768150
97MAP4K20.29289569
98ADRBK10.28266483
99MATK0.28233383
100CSNK2A10.27156817

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.03000142
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.35669799
3Homologous recombination_Homo sapiens_hsa034403.09140836
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63160384
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57526386
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.57059879
7Non-homologous end-joining_Homo sapiens_hsa034502.52361864
8Primary immunodeficiency_Homo sapiens_hsa053402.48828901
9Butanoate metabolism_Homo sapiens_hsa006502.45360987
10Proteasome_Homo sapiens_hsa030502.37916534
11Nitrogen metabolism_Homo sapiens_hsa009102.32236301
12Sulfur metabolism_Homo sapiens_hsa009202.23793570
13Peroxisome_Homo sapiens_hsa041462.18418927
14Propanoate metabolism_Homo sapiens_hsa006402.05280508
15Base excision repair_Homo sapiens_hsa034102.00445997
16Circadian rhythm_Homo sapiens_hsa047101.85932898
17Fatty acid metabolism_Homo sapiens_hsa012121.80700848
18Protein export_Homo sapiens_hsa030601.80110062
19One carbon pool by folate_Homo sapiens_hsa006701.75862468
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62936204
21Phototransduction_Homo sapiens_hsa047441.62771393
22Fanconi anemia pathway_Homo sapiens_hsa034601.42428461
23Fatty acid elongation_Homo sapiens_hsa000621.37994546
24Tryptophan metabolism_Homo sapiens_hsa003801.35538134
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.35152709
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34894727
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34648105
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29251896
29Fat digestion and absorption_Homo sapiens_hsa049751.27950796
30Folate biosynthesis_Homo sapiens_hsa007901.22139968
31RNA polymerase_Homo sapiens_hsa030201.20527315
32Selenocompound metabolism_Homo sapiens_hsa004501.17903703
33Spliceosome_Homo sapiens_hsa030401.16962289
34Caffeine metabolism_Homo sapiens_hsa002321.16485631
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13477335
36Linoleic acid metabolism_Homo sapiens_hsa005911.13089762
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08884298
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07333518
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.06940167
40DNA replication_Homo sapiens_hsa030301.05269833
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03150659
42Steroid biosynthesis_Homo sapiens_hsa001001.02915303
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99585950
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96139734
45Pyrimidine metabolism_Homo sapiens_hsa002400.95396117
46Phenylalanine metabolism_Homo sapiens_hsa003600.92287022
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91585666
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90304449
49N-Glycan biosynthesis_Homo sapiens_hsa005100.84070654
50Oxidative phosphorylation_Homo sapiens_hsa001900.79507548
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78972382
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76415291
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73253144
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72169255
55Purine metabolism_Homo sapiens_hsa002300.69787324
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69093335
57Carbon metabolism_Homo sapiens_hsa012000.68746188
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68106031
59RNA transport_Homo sapiens_hsa030130.67665582
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66812557
61Pancreatic secretion_Homo sapiens_hsa049720.66375542
62beta-Alanine metabolism_Homo sapiens_hsa004100.65761703
63Hedgehog signaling pathway_Homo sapiens_hsa043400.63888214
64Vitamin digestion and absorption_Homo sapiens_hsa049770.63864908
65Arachidonic acid metabolism_Homo sapiens_hsa005900.62640363
66Mismatch repair_Homo sapiens_hsa034300.62638366
67Tyrosine metabolism_Homo sapiens_hsa003500.60212268
68RNA degradation_Homo sapiens_hsa030180.59344486
69Cell cycle_Homo sapiens_hsa041100.59240408
70Chemical carcinogenesis_Homo sapiens_hsa052040.57222961
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.56397603
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55461687
73Metabolic pathways_Homo sapiens_hsa011000.54665352
74Hematopoietic cell lineage_Homo sapiens_hsa046400.51552037
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.49788073
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49647609
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46632365
78African trypanosomiasis_Homo sapiens_hsa051430.44344001
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43760998
80ABC transporters_Homo sapiens_hsa020100.43328730
81Protein digestion and absorption_Homo sapiens_hsa049740.40807214
82Retinol metabolism_Homo sapiens_hsa008300.39775607
83Biosynthesis of amino acids_Homo sapiens_hsa012300.39115050
84p53 signaling pathway_Homo sapiens_hsa041150.38191110
85Glycerolipid metabolism_Homo sapiens_hsa005610.37934755
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37394140
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36489431
88Malaria_Homo sapiens_hsa051440.36454871
89Fructose and mannose metabolism_Homo sapiens_hsa000510.34939938
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33494547
91Nucleotide excision repair_Homo sapiens_hsa034200.33070450
92Shigellosis_Homo sapiens_hsa051310.31618866
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.31456281
94Basal cell carcinoma_Homo sapiens_hsa052170.31073032
95Fatty acid degradation_Homo sapiens_hsa000710.27738529
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27254663
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.26285788
98Arginine and proline metabolism_Homo sapiens_hsa003300.26248353
99Parkinsons disease_Homo sapiens_hsa050120.25926651
100Olfactory transduction_Homo sapiens_hsa047400.25664739

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