PARP4P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)7.88895377
2regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)7.08762065
3DNA deamination (GO:0045006)6.40973164
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.66102119
5regulation of hypersensitivity (GO:0002883)5.11030066
6cytidine metabolic process (GO:0046087)4.92061283
7cytidine catabolic process (GO:0006216)4.92061283
8cytidine deamination (GO:0009972)4.92061283
9cellular response to interleukin-15 (GO:0071350)4.46090217
10regulation of acute inflammatory response to antigenic stimulus (GO:0002864)4.32745642
11pyrimidine ribonucleoside catabolic process (GO:0046133)4.23203530
12positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.12068442
13positive regulation of interleukin-17 production (GO:0032740)4.11491882
14positive regulation of mast cell activation involved in immune response (GO:0033008)4.00487524
15positive regulation of mast cell degranulation (GO:0043306)4.00487524
16sleep (GO:0030431)3.80006931
17somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.78100520
18somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.78100520
19isotype switching (GO:0045190)3.78100520
20protein neddylation (GO:0045116)3.76860126
21response to interleukin-15 (GO:0070672)3.70806960
22regulation of defense response to virus by host (GO:0050691)3.63669261
23positive regulation of mast cell activation (GO:0033005)3.37114283
24positive regulation of alpha-beta T cell proliferation (GO:0046641)3.29234418
25ATP synthesis coupled proton transport (GO:0015986)3.22661586
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22661586
27regulation of chronic inflammatory response (GO:0002676)3.22038931
28ribosomal small subunit assembly (GO:0000028)3.17158714
29mitochondrial DNA replication (GO:0006264)3.13906655
30proteasome assembly (GO:0043248)3.08201274
31platelet dense granule organization (GO:0060155)3.06366252
32positive regulation of defense response to virus by host (GO:0002230)3.04302813
33T-helper 1 type immune response (GO:0042088)2.97606374
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.93776665
35phosphorylated carbohydrate dephosphorylation (GO:0046838)2.93735626
36inositol phosphate dephosphorylation (GO:0046855)2.93735626
37T cell migration (GO:0072678)2.92537915
38centriole replication (GO:0007099)2.91518860
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91482606
40organic cation transport (GO:0015695)2.90782076
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89326252
42negative regulation of cell killing (GO:0031342)2.89326252
43antigen processing and presentation via MHC class Ib (GO:0002475)2.87295129
44DNA catabolic process, exonucleolytic (GO:0000738)2.84690103
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81166925
46somatic hypermutation of immunoglobulin genes (GO:0016446)2.79340554
47somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79340554
48positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.77409464
49somatic diversification of immunoglobulins (GO:0016445)2.76738572
50cellular response to dsRNA (GO:0071359)2.72661094
51somatic recombination of immunoglobulin gene segments (GO:0016447)2.71978321
52positive regulation of T cell mediated cytotoxicity (GO:0001916)2.68486145
53regulation of alpha-beta T cell proliferation (GO:0046640)2.67929627
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67586404
55metallo-sulfur cluster assembly (GO:0031163)2.66748394
56iron-sulfur cluster assembly (GO:0016226)2.66748394
57chaperone-mediated protein transport (GO:0072321)2.66575172
58synapsis (GO:0007129)2.66394237
59regulation of germinal center formation (GO:0002634)2.65667850
60establishment of protein localization to mitochondrial membrane (GO:0090151)2.63171841
61regulation of mast cell degranulation (GO:0043304)2.60815427
62positive regulation of DNA repair (GO:0045739)2.60486534
63natural killer cell activation (GO:0030101)2.58650294
64B cell activation involved in immune response (GO:0002312)2.56060550
65regulation of inflammatory response to antigenic stimulus (GO:0002861)2.55956044
66regulation of T cell mediated cytotoxicity (GO:0001914)2.54995485
67mast cell activation (GO:0045576)2.52574674
68meiotic chromosome segregation (GO:0045132)2.51316640
69signal peptide processing (GO:0006465)2.46520926
70regulation of mast cell activation involved in immune response (GO:0033006)2.45960373
71negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.45686652
72regulation of activation of Janus kinase activity (GO:0010533)2.44615705
73nucleotide transmembrane transport (GO:1901679)2.44444082
74organelle disassembly (GO:1903008)2.43602256
75response to interferon-beta (GO:0035456)2.42736175
76positive regulation of leukocyte degranulation (GO:0043302)2.41883145
77histone mRNA metabolic process (GO:0008334)2.41170365
78cytokine biosynthetic process (GO:0042089)2.41145111
79glycerol ether metabolic process (GO:0006662)2.39921029
80interferon-gamma production (GO:0032609)2.38273617
81rRNA catabolic process (GO:0016075)2.37923074
82positive regulation of NF-kappaB import into nucleus (GO:0042346)2.37471985
83kynurenine metabolic process (GO:0070189)2.36633096
84inositol phosphate catabolic process (GO:0071545)2.36260488
85response to redox state (GO:0051775)2.35020547
86branched-chain amino acid catabolic process (GO:0009083)2.33790465
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.32945129
88L-fucose catabolic process (GO:0042355)2.30868661
89fucose catabolic process (GO:0019317)2.30868661
90L-fucose metabolic process (GO:0042354)2.30868661
91regulation of cellular amino acid metabolic process (GO:0006521)2.29683835
92tryptophan catabolic process (GO:0006569)2.29232312
93indole-containing compound catabolic process (GO:0042436)2.29232312
94indolalkylamine catabolic process (GO:0046218)2.29232312
95DNA ligation (GO:0006266)2.28402209
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.27558776
97dendritic cell chemotaxis (GO:0002407)2.27341577
98positive regulation of mitochondrial fission (GO:0090141)2.27090497
99cellular response to interferon-beta (GO:0035458)2.27008068
100negative regulation of viral genome replication (GO:0045071)2.27004308

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.61069911
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.39746855
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.32760111
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.68410921
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.41023844
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.10918212
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93666827
8VDR_23849224_ChIP-Seq_CD4+_Human2.80676907
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59168062
10ELK1_19687146_ChIP-ChIP_HELA_Human2.51529755
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.49694928
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49364208
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43592799
14E2F7_22180533_ChIP-Seq_HELA_Human2.36642984
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.25948584
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23567432
17VDR_22108803_ChIP-Seq_LS180_Human2.23170793
18FOXP3_21729870_ChIP-Seq_TREG_Human2.21276544
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18031849
20GATA1_22025678_ChIP-Seq_K562_Human2.15391635
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14740549
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.14472743
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.99502035
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.93364185
25IRF1_19129219_ChIP-ChIP_H3396_Human1.92593088
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82877767
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.82146346
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73018685
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70210602
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66204766
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62458691
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57991860
33MYC_18940864_ChIP-ChIP_HL60_Human1.57215523
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56704131
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53630344
36DCP1A_22483619_ChIP-Seq_HELA_Human1.52923199
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52773254
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.49101691
39ZNF274_21170338_ChIP-Seq_K562_Hela1.45771423
40GATA3_26560356_Chip-Seq_TH2_Human1.45757273
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44545068
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39770012
43EWS_26573619_Chip-Seq_HEK293_Human1.37790434
44TAF15_26573619_Chip-Seq_HEK293_Human1.37034937
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32893671
46MYB_26560356_Chip-Seq_TH2_Human1.31753962
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30960544
48FUS_26573619_Chip-Seq_HEK293_Human1.29588221
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29575108
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.29575108
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29529379
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.27409500
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27011884
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23643385
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23069990
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22707614
57SPI1_23547873_ChIP-Seq_NB4_Human1.21855654
58ER_23166858_ChIP-Seq_MCF-7_Human1.20907822
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17762877
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15424417
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14973456
62IGF1R_20145208_ChIP-Seq_DFB_Human1.11167321
63TP53_22573176_ChIP-Seq_HFKS_Human1.10341234
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09787675
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07357487
66SCL_19346495_ChIP-Seq_HPC-7_Human1.06307064
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05848487
68GATA3_27048872_Chip-Seq_THYMUS_Human1.05098381
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04362438
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04341218
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.04115614
72SOX2_19829295_ChIP-Seq_ESCs_Human1.03393524
73NANOG_19829295_ChIP-Seq_ESCs_Human1.03393524
74SALL4_22934838_ChIP-ChIP_CD34+_Human1.02353453
75GABP_19822575_ChIP-Seq_HepG2_Human1.01026834
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00178164
77NCOR_22424771_ChIP-Seq_293T_Human0.98829601
78SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98175148
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95617300
80MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94336698
81TTF2_22483619_ChIP-Seq_HELA_Human0.94283724
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94272113
83P300_19829295_ChIP-Seq_ESCs_Human0.93990891
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93762250
85NFE2_27457419_Chip-Seq_LIVER_Mouse0.93624456
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.93181478
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92264486
88ERG_20517297_ChIP-Seq_VCAP_Human0.91464457
89RBPJ_21746931_ChIP-Seq_IB4_Human0.91290871
90MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91289445
91AR_20517297_ChIP-Seq_VCAP_Human0.91183615
92CBP_20019798_ChIP-Seq_JUKART_Human0.90979930
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90979930
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89346292
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89312176
96MYB_26560356_Chip-Seq_TH1_Human0.89193589
97GATA3_26560356_Chip-Seq_TH1_Human0.88361896
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86367050
99PHF8_20622853_ChIP-Seq_HELA_Human0.85901257
100NANOG_20526341_ChIP-Seq_ESCs_Human0.85688879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.74113558
2MP0005084_abnormal_gallbladder_morpholo3.19182351
3MP0005075_abnormal_melanosome_morpholog2.73061665
4MP0000465_gastrointestinal_hemorrhage2.70156597
5MP0003724_increased_susceptibility_to2.63467988
6MP0001835_abnormal_antigen_presentation2.61277720
7MP0002148_abnormal_hypersensitivity_rea2.51621328
8MP0004147_increased_porphyrin_level2.37369964
9MP0002876_abnormal_thyroid_physiology2.34368736
10MP0008875_abnormal_xenobiotic_pharmacok2.33544741
11MP0009785_altered_susceptibility_to2.20658097
12MP0000685_abnormal_immune_system2.11446100
13MP0003011_delayed_dark_adaptation2.00338448
14MP0005000_abnormal_immune_tolerance1.99134377
15MP0008058_abnormal_DNA_repair1.98558106
16MP0000569_abnormal_digit_pigmentation1.89457688
17MP0006072_abnormal_retinal_apoptosis1.84234455
18MP0002928_abnormal_bile_duct1.79097013
19MP0001800_abnormal_humoral_immune1.77918540
20MP0002723_abnormal_immune_serum1.69275914
21MP0003786_premature_aging1.68492987
22MP0002452_abnormal_antigen_presenting1.67262945
23MP0008877_abnormal_DNA_methylation1.64289926
24MP0005377_hearing/vestibular/ear_phenot1.63911766
25MP0003878_abnormal_ear_physiology1.63911766
26MP0003436_decreased_susceptibility_to1.56701627
27MP0003252_abnormal_bile_duct1.50018595
28MP0001819_abnormal_immune_cell1.48943716
29MP0010094_abnormal_chromosome_stability1.48660744
30MP0002420_abnormal_adaptive_immunity1.46794855
31MP0005379_endocrine/exocrine_gland_phen1.46569582
32MP0001873_stomach_inflammation1.44373568
33MP0002877_abnormal_melanocyte_morpholog1.42360883
34MP0003718_maternal_effect1.41846678
35MP0002419_abnormal_innate_immunity1.41816904
36MP0009764_decreased_sensitivity_to1.41773803
37MP0006292_abnormal_olfactory_placode1.39440172
38MP0004885_abnormal_endolymph1.38789508
39MP0002006_tumorigenesis1.37735650
40MP0005174_abnormal_tail_pigmentation1.37355896
41MP0002166_altered_tumor_susceptibility1.37118446
42MP0002254_reproductive_system_inflammat1.35652439
43MP0003136_yellow_coat_color1.34774821
44MP0005025_abnormal_response_to1.34143178
45MP0002102_abnormal_ear_morphology1.33439702
46MP0002095_abnormal_skin_pigmentation1.33249251
47MP0003806_abnormal_nucleotide_metabolis1.31937606
48MP0003763_abnormal_thymus_physiology1.30793516
49MP0005464_abnormal_platelet_physiology1.30354946
50MP0002163_abnormal_gland_morphology1.29311706
51MP0006035_abnormal_mitochondrial_morpho1.29209098
52MP0002138_abnormal_hepatobiliary_system1.26296054
53MP0003787_abnormal_imprinting1.25990067
54MP0002398_abnormal_bone_marrow1.24418394
55MP0005387_immune_system_phenotype1.23670635
56MP0001790_abnormal_immune_system1.23670635
57MP0008469_abnormal_protein_level1.19711139
58MP0005551_abnormal_eye_electrophysiolog1.18243874
59MP0006082_CNS_inflammation1.18086190
60MP0001188_hyperpigmentation1.17341713
61MP0006054_spinal_hemorrhage1.14615623
62MP0000716_abnormal_immune_system1.14189867
63MP0001845_abnormal_inflammatory_respons1.12150270
64MP0002736_abnormal_nociception_after1.11401837
65MP0002938_white_spotting1.10364800
66MP0000689_abnormal_spleen_morphology1.08082302
67MP0000427_abnormal_hair_cycle1.08017599
68MP0002405_respiratory_system_inflammati1.05234287
69MP0002837_dystrophic_cardiac_calcinosis1.03689630
70MP0010386_abnormal_urinary_bladder1.02903200
71MP0009765_abnormal_xenobiotic_induced1.01588551
72MP0001765_abnormal_ion_homeostasis0.99991580
73MP0005253_abnormal_eye_physiology0.99825140
74MP0005389_reproductive_system_phenotype0.99319842
75MP0010155_abnormal_intestine_physiology0.99310322
76MP0001764_abnormal_homeostasis0.97759579
77MP0003195_calcinosis0.97674403
78MP0002429_abnormal_blood_cell0.96189942
79MP0001905_abnormal_dopamine_level0.95177169
80MP0000681_abnormal_thyroid_gland0.93049195
81MP0002722_abnormal_immune_system0.92149098
82MP0001533_abnormal_skeleton_physiology0.90805105
83MP0005410_abnormal_fertilization0.90060822
84MP0004381_abnormal_hair_follicle0.89200980
85MP0003186_abnormal_redox_activity0.88983653
86MP0000703_abnormal_thymus_morphology0.88875863
87MP0003191_abnormal_cellular_cholesterol0.88161516
88MP0003866_abnormal_defecation0.87659240
89MP0006036_abnormal_mitochondrial_physio0.87176487
90MP0003303_peritoneal_inflammation0.87125246
91MP0003943_abnormal_hepatobiliary_system0.86543322
92MP0000358_abnormal_cell_content/0.85975473
93MP0002160_abnormal_reproductive_system0.85802729
94MP0005310_abnormal_salivary_gland0.85165404
95MP0005332_abnormal_amino_acid0.85062170
96MP0001501_abnormal_sleep_pattern0.84541402
97MP0001968_abnormal_touch/_nociception0.80521186
98MP0002019_abnormal_tumor_incidence0.76525214
99MP0001853_heart_inflammation0.76056216
100MP0004947_skin_inflammation0.75647171

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)3.60255878
2Absent rod-and cone-mediated responses on ERG (HP:0007688)3.40278137
3Abnormality of midbrain morphology (HP:0002418)3.40155097
4Molar tooth sign on MRI (HP:0002419)3.40155097
5Short tibia (HP:0005736)3.36434291
6Increased hepatocellular lipid droplets (HP:0006565)3.30499798
7Renal Fanconi syndrome (HP:0001994)3.22568786
8Lipid accumulation in hepatocytes (HP:0006561)3.15880159
9Medial flaring of the eyebrow (HP:0010747)3.12544608
10Abnormality of the renal cortex (HP:0011035)3.05634265
11Aplasia/Hypoplasia of the tibia (HP:0005772)3.02635271
12IgG deficiency (HP:0004315)2.90443465
13Hyperglycinemia (HP:0002154)2.86190487
14Pancreatic fibrosis (HP:0100732)2.83707363
15Increased CSF lactate (HP:0002490)2.79405383
16Stomach cancer (HP:0012126)2.77180854
17Congenital, generalized hypertrichosis (HP:0004540)2.72837693
18Methylmalonic acidemia (HP:0002912)2.72815397
19Hepatocellular necrosis (HP:0001404)2.72286629
20Papilledema (HP:0001085)2.71293294
21Nephronophthisis (HP:0000090)2.68824048
22Retrobulbar optic neuritis (HP:0100654)2.68279064
23Optic neuritis (HP:0100653)2.68279064
24Abnormal rod and cone electroretinograms (HP:0008323)2.65883766
25Hepatic necrosis (HP:0002605)2.63262665
26Pancreatic cysts (HP:0001737)2.62743881
27Mitochondrial inheritance (HP:0001427)2.60359696
28Severe combined immunodeficiency (HP:0004430)2.60279965
29Abnormality of T cell number (HP:0011839)2.56555929
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.53958841
31Abnormal biliary tract physiology (HP:0012439)2.52264338
32Bile duct proliferation (HP:0001408)2.52264338
33Aplasia/Hypoplasia of the spleen (HP:0010451)2.51292144
34T lymphocytopenia (HP:0005403)2.47946060
35Facial diplegia (HP:0001349)2.44283990
36Abnormality of eosinophils (HP:0001879)2.41673903
37Asplenia (HP:0001746)2.39908771
38Increased serum lactate (HP:0002151)2.38618094
39Myositis (HP:0100614)2.38567536
40Metaphyseal dysplasia (HP:0100255)2.32497788
41Elevated erythrocyte sedimentation rate (HP:0003565)2.27849387
42True hermaphroditism (HP:0010459)2.27725932
43Prolonged neonatal jaundice (HP:0006579)2.26749745
44Increased intramyocellular lipid droplets (HP:0012240)2.24340399
45Stomatitis (HP:0010280)2.23445238
46Abnormality of the renal medulla (HP:0100957)2.23042953
47Hyperglycinuria (HP:0003108)2.21427902
48Anhidrosis (HP:0000970)2.20859187
49Sensory axonal neuropathy (HP:0003390)2.19568953
50Abnormality of alanine metabolism (HP:0010916)2.19008161
51Hyperalaninemia (HP:0003348)2.19008161
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19008161
53Abnormality of T cells (HP:0002843)2.18289836
54Thyroiditis (HP:0100646)2.16427820
55Abnormality of serum amino acid levels (HP:0003112)2.15400749
56Combined immunodeficiency (HP:0005387)2.12415796
573-Methylglutaconic aciduria (HP:0003535)2.10836045
58Orchitis (HP:0100796)2.10522426
59Supernumerary spleens (HP:0009799)2.10383970
60Constricted visual fields (HP:0001133)2.09385748
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07350108
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05067194
63Lactic acidosis (HP:0003128)2.04471796
64Disinhibition (HP:0000734)2.00304892
65Aplastic anemia (HP:0001915)1.99180393
66Increased muscle lipid content (HP:0009058)1.98587651
67Exertional dyspnea (HP:0002875)1.98450761
68Acute necrotizing encephalopathy (HP:0006965)1.97651293
69Abnormality of glycine metabolism (HP:0010895)1.96602482
70Abnormality of serine family amino acid metabolism (HP:0010894)1.96602482
71Pancreatitis (HP:0001733)1.92346385
72Congenital primary aphakia (HP:0007707)1.91435866
73Poor head control (HP:0002421)1.91384553
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91192763
75Abolished electroretinogram (ERG) (HP:0000550)1.90917808
76Hypoglycemic seizures (HP:0002173)1.89754880
77Abnormal mitochondria in muscle tissue (HP:0008316)1.89159257
78Progressive inability to walk (HP:0002505)1.88468910
79Ketosis (HP:0001946)1.88375798
80Abnormality of the phalanges of the 2nd finger (HP:0009541)1.88187880
81Pulmonary fibrosis (HP:0002206)1.87988314
82Hypoglycemic coma (HP:0001325)1.87694211
83Abnormality of the prostate (HP:0008775)1.87426615
84Aplasia/hypoplasia of the uterus (HP:0008684)1.85323598
85Abnormality of renal resorption (HP:0011038)1.83746853
86Adrenal hypoplasia (HP:0000835)1.82235762
87Nephrogenic diabetes insipidus (HP:0009806)1.79441446
88Abnormality of T cell physiology (HP:0011840)1.79301487
89Progressive macrocephaly (HP:0004481)1.78790444
90Attenuation of retinal blood vessels (HP:0007843)1.76438488
91Abnormal delayed hypersensitivity skin test (HP:0002963)1.75798501
92Respiratory difficulties (HP:0002880)1.74105169
93Large for gestational age (HP:0001520)1.73282818
94Abnormality of macular pigmentation (HP:0008002)1.72372301
95Neoplasm of head and neck (HP:0012288)1.72007534
96Esophageal neoplasm (HP:0100751)1.72007534
97Abnormal number of erythroid precursors (HP:0012131)1.71888384
98Abnormality of vitamin B metabolism (HP:0004340)1.71047233
99Gait imbalance (HP:0002141)1.70077338
100Vacuolated lymphocytes (HP:0001922)1.69887583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.66298704
2MST43.32252867
3MAP4K23.30111693
4EIF2AK33.26754612
5NUAK12.77252984
6BUB12.62153059
7MAP3K142.42081066
8TIE12.25536901
9MATK2.21516463
10TESK22.02679233
11FRK1.98861154
12TAOK31.92406322
13ADRBK21.83069640
14TLK11.77196091
15FES1.72846739
16BCKDK1.66762288
17BMPR21.65122642
18PLK21.63651810
19GRK11.60714534
20SIK31.59228897
21IKBKB1.58502016
22STK161.55468712
23IKBKE1.55163776
24TBK11.53836171
25EIF2AK11.53216142
26ZAK1.48422723
27TRIM281.48087880
28KDR1.47602848
29KIT1.47139460
30PASK1.46732494
31INSRR1.39894752
32SRPK11.39271227
33VRK21.37241921
34EIF2AK21.36416455
35JAK11.27020947
36ERBB31.21346401
37MAP4K11.20856324
38PLK31.19368752
39MKNK11.14752104
40VRK11.14150064
41PLK41.04171095
42TEC1.01916208
43MARK30.99164073
44MAPK70.95413296
45CDK190.93852031
46GRK60.93184635
47TNK20.92036482
48TGFBR10.91256033
49JAK30.88903323
50CCNB10.88866983
51MAP3K120.85459344
52MAP2K20.80896915
53CDC70.79512821
54MAPKAPK30.77897860
55LYN0.76889487
56NME10.76623926
57LCK0.76171895
58OXSR10.75910802
59PRKCQ0.75019832
60PTK2B0.73806564
61DAPK10.73000782
62BCR0.70877472
63WNK30.69325054
64IRAK40.68535859
65STK100.68014113
66TNIK0.63452320
67PRKCI0.62710337
68ACVR1B0.61890365
69SYK0.61039245
70DAPK20.59671413
71FLT30.57475129
72SCYL20.53704089
73PHKG10.52085076
74PHKG20.52085076
75PAK30.52043995
76MAP2K60.50647348
77NEK10.50001722
78ALK0.47267344
79MAP3K100.44284752
80PRKG20.44057131
81CSNK2A10.43953977
82PRKCE0.42754814
83BTK0.42310847
84IGF1R0.41949636
85HCK0.36420722
86CSNK1G30.35828939
87ADRBK10.35350106
88PRKCD0.33462527
89ABL10.32472969
90MAP3K50.31370695
91CHUK0.30231795
92PIM10.30056859
93CAMKK20.29400032
94FGFR10.28106988
95CSK0.27979451
96PRKCG0.27158336
97ATR0.26714401
98PLK10.25521731
99MYLK0.24984211
100RPS6KA50.24794709

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.35817635
2Non-homologous end-joining_Homo sapiens_hsa034503.11636952
3Asthma_Homo sapiens_hsa053103.07359082
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.45110960
5Homologous recombination_Homo sapiens_hsa034402.40097716
6Graft-versus-host disease_Homo sapiens_hsa053322.35091739
7Protein export_Homo sapiens_hsa030602.25530068
8Oxidative phosphorylation_Homo sapiens_hsa001902.23849355
9Mismatch repair_Homo sapiens_hsa034302.19574219
10Primary immunodeficiency_Homo sapiens_hsa053402.18779004
11Ribosome_Homo sapiens_hsa030102.10784667
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08357085
13Base excision repair_Homo sapiens_hsa034102.05553357
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02808774
15DNA replication_Homo sapiens_hsa030302.00706107
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96054251
17Propanoate metabolism_Homo sapiens_hsa006401.90005121
18Allograft rejection_Homo sapiens_hsa053301.87492569
19Sulfur metabolism_Homo sapiens_hsa009201.83615207
20Autoimmune thyroid disease_Homo sapiens_hsa053201.83533155
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73109705
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68744536
23One carbon pool by folate_Homo sapiens_hsa006701.67005510
24Type I diabetes mellitus_Homo sapiens_hsa049401.66574629
25Antigen processing and presentation_Homo sapiens_hsa046121.65943653
26Parkinsons disease_Homo sapiens_hsa050121.62556515
27Nucleotide excision repair_Homo sapiens_hsa034201.57435731
28Rheumatoid arthritis_Homo sapiens_hsa053231.51633427
29Tryptophan metabolism_Homo sapiens_hsa003801.39694962
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36521264
31Fanconi anemia pathway_Homo sapiens_hsa034601.35451528
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35029293
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32488269
34Butanoate metabolism_Homo sapiens_hsa006501.27619041
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27615576
36RNA degradation_Homo sapiens_hsa030181.27457913
37RNA polymerase_Homo sapiens_hsa030201.19205720
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13389777
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12352905
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11229329
41Peroxisome_Homo sapiens_hsa041461.10207256
42RNA transport_Homo sapiens_hsa030131.08314073
43Caffeine metabolism_Homo sapiens_hsa002321.06699269
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04706034
45Hematopoietic cell lineage_Homo sapiens_hsa046401.01281227
46Fatty acid elongation_Homo sapiens_hsa000621.01244122
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00993576
48Selenocompound metabolism_Homo sapiens_hsa004500.99300657
49Huntingtons disease_Homo sapiens_hsa050160.92066634
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88938686
51Alzheimers disease_Homo sapiens_hsa050100.88596351
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87895126
53Pyrimidine metabolism_Homo sapiens_hsa002400.85818101
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85649087
55African trypanosomiasis_Homo sapiens_hsa051430.83558020
56Leishmaniasis_Homo sapiens_hsa051400.83153496
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.81478022
58Basal transcription factors_Homo sapiens_hsa030220.79119778
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77265158
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.75361114
61Legionellosis_Homo sapiens_hsa051340.74728575
62Nitrogen metabolism_Homo sapiens_hsa009100.73911919
63Herpes simplex infection_Homo sapiens_hsa051680.73281002
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73207923
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.70484746
66Purine metabolism_Homo sapiens_hsa002300.68975799
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67737493
68Spliceosome_Homo sapiens_hsa030400.65811450
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.63093772
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62875512
71Measles_Homo sapiens_hsa051620.60879557
72Circadian rhythm_Homo sapiens_hsa047100.58156690
73Carbon metabolism_Homo sapiens_hsa012000.56725776
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.56715653
75Malaria_Homo sapiens_hsa051440.56434761
76Metabolic pathways_Homo sapiens_hsa011000.55935764
77Linoleic acid metabolism_Homo sapiens_hsa005910.55319170
78Chemical carcinogenesis_Homo sapiens_hsa052040.53316048
79Epstein-Barr virus infection_Homo sapiens_hsa051690.52486436
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52114526
81ABC transporters_Homo sapiens_hsa020100.48991738
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46803021
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46426318
84Glycerolipid metabolism_Homo sapiens_hsa005610.44608766
85Regulation of autophagy_Homo sapiens_hsa041400.43604237
86Retinol metabolism_Homo sapiens_hsa008300.42820132
87Lysosome_Homo sapiens_hsa041420.41658775
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41215752
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40777941
90Phototransduction_Homo sapiens_hsa047440.40423369
91Fat digestion and absorption_Homo sapiens_hsa049750.40371798
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37538502
93Arachidonic acid metabolism_Homo sapiens_hsa005900.36860242
94Collecting duct acid secretion_Homo sapiens_hsa049660.35423647
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35152955
96Pyruvate metabolism_Homo sapiens_hsa006200.35071839
97Influenza A_Homo sapiens_hsa051640.34484930
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32329441
99Vitamin B6 metabolism_Homo sapiens_hsa007500.32158959
100Viral myocarditis_Homo sapiens_hsa054160.31007389

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