PARP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.12859419
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78739089
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.46437392
4male meiosis I (GO:0007141)5.40047792
5synaptonemal complex assembly (GO:0007130)5.38139600
6piRNA metabolic process (GO:0034587)5.37962076
7locomotory exploration behavior (GO:0035641)5.20651496
8vocalization behavior (GO:0071625)5.13888186
9chromosome organization involved in meiosis (GO:0070192)5.10589761
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.10044529
11synapsis (GO:0007129)5.08205118
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.00228184
13synaptic vesicle exocytosis (GO:0016079)4.93660035
14DNA methylation involved in gamete generation (GO:0043046)4.90738621
15glutamate secretion (GO:0014047)4.90089952
16synaptonemal complex organization (GO:0070193)4.83307009
17histone H3-K9 demethylation (GO:0033169)4.76219427
18regulation of NFAT protein import into nucleus (GO:0051532)4.72176721
19regulation of synaptic vesicle exocytosis (GO:2000300)4.68874574
20protein localization to synapse (GO:0035418)4.65888374
21neuron cell-cell adhesion (GO:0007158)4.64554816
22regulation of glutamate receptor signaling pathway (GO:1900449)4.62029249
23proline transport (GO:0015824)4.57560631
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.52326305
25layer formation in cerebral cortex (GO:0021819)4.51360349
26male meiosis (GO:0007140)4.43239847
27exploration behavior (GO:0035640)4.28459125
28regulation of synapse structural plasticity (GO:0051823)4.17650815
29regulation of synaptic vesicle transport (GO:1902803)4.15407488
30histone H3-K36 demethylation (GO:0070544)4.09875994
31neurotransmitter secretion (GO:0007269)4.06539729
32ionotropic glutamate receptor signaling pathway (GO:0035235)4.04520238
33regulation of neuronal synaptic plasticity (GO:0048168)4.01221405
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.95291410
35dendritic spine morphogenesis (GO:0060997)3.93278204
36synaptic transmission, glutamatergic (GO:0035249)3.93115426
37meiosis I (GO:0007127)3.88413178
38positive regulation of synapse maturation (GO:0090129)3.87534728
39neurotransmitter-gated ion channel clustering (GO:0072578)3.82604518
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80987764
41neuron recognition (GO:0008038)3.68475027
42glutamate receptor signaling pathway (GO:0007215)3.67329387
43meiotic nuclear division (GO:0007126)3.66137696
44ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.63144970
45neuronal action potential propagation (GO:0019227)3.62183882
46cell migration in hindbrain (GO:0021535)3.62108208
47neuron-neuron synaptic transmission (GO:0007270)3.60056257
48dendrite morphogenesis (GO:0048813)3.59299189
49DNA synthesis involved in DNA repair (GO:0000731)3.58405803
50axonal fasciculation (GO:0007413)3.55173609
51establishment of mitochondrion localization (GO:0051654)3.50629083
52establishment of nucleus localization (GO:0040023)3.49449473
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48623275
54pyrimidine nucleobase catabolic process (GO:0006208)3.46845192
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44928201
56positive regulation of membrane potential (GO:0045838)3.42436817
57central nervous system neuron axonogenesis (GO:0021955)3.41843373
58activation of protein kinase A activity (GO:0034199)3.40521235
59macroautophagy (GO:0016236)3.39599339
60urinary tract smooth muscle contraction (GO:0014848)3.38610372
61long-term memory (GO:0007616)3.37367764
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.36611181
63postsynaptic membrane organization (GO:0001941)3.34086465
64regulation of dendritic spine morphogenesis (GO:0061001)3.30034923
65neurotransmitter transport (GO:0006836)3.26099166
66regulation of postsynaptic membrane potential (GO:0060078)3.22323924
67synaptic vesicle endocytosis (GO:0048488)3.21738777
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20923222
69presynaptic membrane assembly (GO:0097105)3.20188254
70central nervous system projection neuron axonogenesis (GO:0021952)3.19909585
71cerebellar Purkinje cell differentiation (GO:0021702)3.19231373
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18686889
73presynaptic membrane organization (GO:0097090)3.18171226
74auditory behavior (GO:0031223)3.18146430
75gamma-aminobutyric acid transport (GO:0015812)3.16959098
76regulation of neurotransmitter secretion (GO:0046928)3.15770857
77regulation of synaptic plasticity (GO:0048167)3.15504598
78innervation (GO:0060384)3.12144152
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.11545230
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10414618
81neuronal ion channel clustering (GO:0045161)3.10168740
82membrane depolarization during action potential (GO:0086010)3.09340350
83cerebellar granule cell differentiation (GO:0021707)3.06654312
84behavioral defense response (GO:0002209)3.06438036
85behavioral fear response (GO:0001662)3.06438036
86sister chromatid cohesion (GO:0007062)3.05979036
87histone demethylation (GO:0016577)3.05706549
88regulation of microtubule-based movement (GO:0060632)3.04258965
89histone lysine demethylation (GO:0070076)3.03643736
90neuromuscular process controlling balance (GO:0050885)3.03079437
91neurofilament cytoskeleton organization (GO:0060052)3.02807315
92regulation of vesicle fusion (GO:0031338)3.02770295
93histone H3-K4 trimethylation (GO:0080182)3.02547391
94signal complex assembly (GO:0007172)2.99832231
95negative regulation of microtubule polymerization (GO:0031115)2.98641178
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97886293
97synapse assembly (GO:0007416)2.97097650
98regulation of synaptic transmission, glutamatergic (GO:0051966)2.96392677
99positive regulation of neurotransmitter secretion (GO:0001956)2.96074261
100prepulse inhibition (GO:0060134)2.94617280
101regulation of synapse maturation (GO:0090128)2.94330317
102transmission of nerve impulse (GO:0019226)2.94244664
103nucleus localization (GO:0051647)2.93007307
104cellular potassium ion homeostasis (GO:0030007)2.92267699
105long-term synaptic potentiation (GO:0060291)2.92089058
106regulation of neurotransmitter levels (GO:0001505)2.91612260
107fear response (GO:0042596)2.90380519
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90233447
109membrane depolarization (GO:0051899)2.90063894
110cell communication by electrical coupling (GO:0010644)2.89977448
111organelle transport along microtubule (GO:0072384)2.89564271
112response to auditory stimulus (GO:0010996)2.89086088
113dendritic spine organization (GO:0097061)2.88737808
114cerebellum development (GO:0021549)2.88246527
115positive regulation of dendritic spine development (GO:0060999)2.86435207
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85200037
117dopamine receptor signaling pathway (GO:0007212)2.84749335
118regulation of meiosis I (GO:0060631)2.84265119
119positive regulation of action potential (GO:0045760)2.82987879
120response to pheromone (GO:0019236)2.82732451
121adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.82726856
122regulation of neurotransmitter transport (GO:0051588)2.82475603
123positive regulation of neurotransmitter transport (GO:0051590)2.81984691
124nucleobase catabolic process (GO:0046113)2.81424237
125synapse organization (GO:0050808)2.81351111
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81261908
127histone H4-K12 acetylation (GO:0043983)2.80586885
128social behavior (GO:0035176)2.77538573
129intraspecies interaction between organisms (GO:0051703)2.77538573
130protein dealkylation (GO:0008214)2.76854415
131protein demethylation (GO:0006482)2.76854415
132mitochondrion transport along microtubule (GO:0047497)2.76068218
133establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.76068218
134interkinetic nuclear migration (GO:0022027)2.75398006
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75030945
136DNA methylation (GO:0006306)2.73851028
137DNA alkylation (GO:0006305)2.73851028
138brain morphogenesis (GO:0048854)2.73730128
139cerebral cortex neuron differentiation (GO:0021895)2.70316222
140vesicle transport along microtubule (GO:0047496)2.69657178
141regulation of glycogen (starch) synthase activity (GO:2000465)2.67525603
142peptidyl-lysine trimethylation (GO:0018023)2.64518776
143behavioral response to nicotine (GO:0035095)2.64514036
144histone H3-K9 modification (GO:0061647)2.64323671
145histone H4-K16 acetylation (GO:0043984)2.64111425
146cilium or flagellum-dependent cell motility (GO:0001539)2.54602992
147histone H3-K9 methylation (GO:0051567)2.54574736
148positive regulation of CREB transcription factor activity (GO:0032793)2.54187662
149microtubule nucleation (GO:0007020)2.53720091
150embryonic body morphogenesis (GO:0010172)2.53528642
151negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.51951180
152positive regulation of meiosis (GO:0045836)2.50976019
153neuromuscular synaptic transmission (GO:0007274)2.50631524
154regulation of respiratory system process (GO:0044065)2.49767083
155adult walking behavior (GO:0007628)2.49519873
156histone lysine methylation (GO:0034968)2.48198376
157meiotic cell cycle process (GO:1903046)2.46613433
158positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.45791495
159establishment of protein localization to Golgi (GO:0072600)2.45093657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.03137191
2GBX2_23144817_ChIP-Seq_PC3_Human3.10344808
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02451746
4REST_21632747_ChIP-Seq_MESCs_Mouse2.95199171
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85199000
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77440286
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73491488
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73491488
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.69213670
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57250678
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.52514867
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.47705877
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44147867
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41495600
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39596812
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39225502
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32561210
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.32091513
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31867224
20DROSHA_22980978_ChIP-Seq_HELA_Human2.31835948
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.28871493
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.26926903
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26568815
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25220381
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24464875
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12419425
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11774337
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.09288264
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.01510868
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00755769
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91667213
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75502396
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.62654016
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59168646
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56986256
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56974253
37IGF1R_20145208_ChIP-Seq_DFB_Human1.46442790
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45176410
39KDM2B_26808549_Chip-Seq_K562_Human1.43992516
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.43669537
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.42983873
42RNF2_27304074_Chip-Seq_NSC_Mouse1.41295943
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39559817
44SMAD4_21799915_ChIP-Seq_A2780_Human1.38465156
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36489515
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35260583
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34996102
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33183742
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32217150
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32002179
51AR_21572438_ChIP-Seq_LNCaP_Human1.30768069
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30362784
53* AR_19668381_ChIP-Seq_PC3_Human1.29527287
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.28833662
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23102794
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22118974
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21782174
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.19777025
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17914624
60* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17397524
61ER_23166858_ChIP-Seq_MCF-7_Human1.16908096
62STAT3_23295773_ChIP-Seq_U87_Human1.16409707
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15047235
64ZNF274_21170338_ChIP-Seq_K562_Hela1.15002080
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14738453
66TAF15_26573619_Chip-Seq_HEK293_Human1.13545697
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13089281
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12625961
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.09980635
70AHR_22903824_ChIP-Seq_MCF-7_Human1.09253715
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05416730
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04240237
73OCT4_19829295_ChIP-Seq_ESCs_Human1.04196296
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03336877
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03336877
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03018377
77* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01024077
78SMC4_20622854_ChIP-Seq_HELA_Human1.00744042
79AR_25329375_ChIP-Seq_VCAP_Human1.00461250
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.00284806
81WDR5_24793694_ChIP-Seq_LNCAP_Human1.00100465
82P300_19829295_ChIP-Seq_ESCs_Human0.99097594
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98683043
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98587790
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98362489
86KDM2B_26808549_Chip-Seq_DND41_Human0.98223656
87PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97370295
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96623648
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96476497
90* ERA_21632823_ChIP-Seq_H3396_Human0.95704951
91SMAD3_21741376_ChIP-Seq_HESCs_Human0.95441617
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.95264633
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95042864
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95032327
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94793711
96SMAD3_21741376_ChIP-Seq_EPCs_Human0.93997406
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93736707
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.93481115
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92473222
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.92198238
101TCF4_23295773_ChIP-Seq_U87_Human0.90824754
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.90776825
103PRDM14_20953172_ChIP-Seq_ESCs_Human0.90129367
104TP53_20018659_ChIP-ChIP_R1E_Mouse0.90034041
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89998069
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89651601
107RUNX2_22187159_ChIP-Seq_PCA_Human0.89478668
108VDR_22108803_ChIP-Seq_LS180_Human0.89260065
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88701363
110* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88475461
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88167937
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87661830
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86023884
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85791277
115* CTCF_27219007_Chip-Seq_Bcells_Human0.85669312
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85381192
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85132058
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84148996
119TP63_19390658_ChIP-ChIP_HaCaT_Human0.83467557
120* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83201883
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82868784
122SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.81925559
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81442598
124CBP_20019798_ChIP-Seq_JUKART_Human0.81442598
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.81151428
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81118444
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79072734
128FUS_26573619_Chip-Seq_HEK293_Human0.78185602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.87105083
2MP0008877_abnormal_DNA_methylation4.22855072
3MP0004270_analgesia4.00472589
4MP0003635_abnormal_synaptic_transmissio3.83335014
5MP0003880_abnormal_central_pattern3.78364468
6MP0002063_abnormal_learning/memory/cond3.18886538
7MP0009745_abnormal_behavioral_response2.86121807
8MP0002572_abnormal_emotion/affect_behav2.69180497
9MP0002734_abnormal_mechanical_nocicepti2.68606256
10MP0002064_seizures2.64738993
11MP0005423_abnormal_somatic_nervous2.64479209
12MP0001968_abnormal_touch/_nociception2.62544907
13MP0004858_abnormal_nervous_system2.56605800
14MP0009046_muscle_twitch2.51655541
15MP0008995_early_reproductive_senescence2.40761398
16MP0001486_abnormal_startle_reflex2.37344481
17MP0002909_abnormal_adrenal_gland2.36827074
18MP0002272_abnormal_nervous_system2.22187300
19MP0002184_abnormal_innervation2.18193804
20MP0002733_abnormal_thermal_nociception2.18078327
21MP0000778_abnormal_nervous_system2.16894597
22MP0002735_abnormal_chemical_nociception2.11682613
23MP0002822_catalepsy2.08798643
24MP0003122_maternal_imprinting2.01405906
25MP0009780_abnormal_chondrocyte_physiolo1.98314764
26MP0005499_abnormal_olfactory_system1.93175039
27MP0005394_taste/olfaction_phenotype1.93175039
28MP0001970_abnormal_pain_threshold1.92881304
29MP0006276_abnormal_autonomic_nervous1.92435842
30MP0003787_abnormal_imprinting1.91579633
31MP0002736_abnormal_nociception_after1.90435107
32MP0004811_abnormal_neuron_physiology1.89377769
33MP0002557_abnormal_social/conspecific_i1.87445279
34MP0001984_abnormal_olfaction1.87352275
35MP0001440_abnormal_grooming_behavior1.85890716
36MP0002067_abnormal_sensory_capabilities1.81622499
37MP0000955_abnormal_spinal_cord1.77942965
38MP0001501_abnormal_sleep_pattern1.77334381
39MP0003646_muscle_fatigue1.74920792
40MP0003698_abnormal_male_reproductive1.69851185
41MP0008569_lethality_at_weaning1.68005161
42MP0002210_abnormal_sex_determination1.66051986
43MP0006292_abnormal_olfactory_placode1.61992250
44MP0005645_abnormal_hypothalamus_physiol1.61627538
45MP0008961_abnormal_basal_metabolism1.60430642
46MP0000383_abnormal_hair_follicle1.56338691
47MP0005386_behavior/neurological_phenoty1.55500614
48MP0004924_abnormal_behavior1.55500614
49MP0002882_abnormal_neuron_morphology1.51874636
50MP0000569_abnormal_digit_pigmentation1.51306381
51MP0005646_abnormal_pituitary_gland1.50789284
52MP0003183_abnormal_peptide_metabolism1.42665882
53MP0002653_abnormal_ependyma_morphology1.39058901
54MP0001929_abnormal_gametogenesis1.36414300
55MP0002066_abnormal_motor_capabilities/c1.31163018
56MP0004885_abnormal_endolymph1.26054684
57MP0005409_darkened_coat_color1.25538886
58MP0001502_abnormal_circadian_rhythm1.22703557
59MP0004130_abnormal_muscle_cell1.21677384
60MP0002152_abnormal_brain_morphology1.20414972
61MP0003329_amyloid_beta_deposits1.19350659
62MP0000015_abnormal_ear_pigmentation1.18521046
63MP0003283_abnormal_digestive_organ1.17954573
64MP0010386_abnormal_urinary_bladder1.17239303
65MP0003879_abnormal_hair_cell1.15521206
66MP0003890_abnormal_embryonic-extraembry1.14531722
67MP0001145_abnormal_male_reproductive1.11214308
68MP0000631_abnormal_neuroendocrine_gland1.10667126
69MP0000427_abnormal_hair_cycle1.07352519
70MP0005551_abnormal_eye_electrophysiolog1.03869341
71MP0003633_abnormal_nervous_system1.02747882
72MP0002069_abnormal_eating/drinking_beha1.02644794
73MP0002160_abnormal_reproductive_system1.01282801
74MP0003121_genomic_imprinting1.00408770
75MP0000653_abnormal_sex_gland0.98500714
76MP0002751_abnormal_autonomic_nervous0.96531548
77MP0008789_abnormal_olfactory_epithelium0.96503932
78MP0002752_abnormal_somatic_nervous0.96085574
79MP0004085_abnormal_heartbeat0.95782716
80MP0001905_abnormal_dopamine_level0.94980969
81MP0006072_abnormal_retinal_apoptosis0.94124031
82MP0004142_abnormal_muscle_tone0.92988577
83MP0004145_abnormal_muscle_electrophysio0.92215216
84MP0005174_abnormal_tail_pigmentation0.91095622
85MP0000013_abnormal_adipose_tissue0.90926050
86MP0001348_abnormal_lacrimal_gland0.90723795
87MP0000678_abnormal_parathyroid_gland0.90477185
88MP0008004_abnormal_stomach_pH0.89802319
89MP0001529_abnormal_vocalization0.89141311
90MP0003861_abnormal_nervous_system0.89018459
91MP0002229_neurodegeneration0.88850145
92MP0003137_abnormal_impulse_conducting0.88670609
93MP0002837_dystrophic_cardiac_calcinosis0.87596239
94MP0001188_hyperpigmentation0.82635136
95MP0001986_abnormal_taste_sensitivity0.81768386
96MP0002638_abnormal_pupillary_reflex0.81621979
97MP0003631_nervous_system_phenotype0.80673728
98MP0002161_abnormal_fertility/fecundity0.79379168
99MP0002928_abnormal_bile_duct0.78607711
100MP0003634_abnormal_glial_cell0.78143248
101MP0005253_abnormal_eye_physiology0.76125649
102MP0004043_abnormal_pH_regulation0.75852364
103MP0005535_abnormal_body_temperature0.75447578
104MP0003690_abnormal_glial_cell0.75086293
105MP0003948_abnormal_gas_homeostasis0.73501496
106MP0005448_abnormal_energy_balance0.71388074
107MP0008872_abnormal_physiological_respon0.71276078
108MP0005187_abnormal_penis_morphology0.68189132
109MP0000604_amyloidosis0.67197155
110MP0003172_abnormal_lysosome_physiology0.65730640
111MP0008874_decreased_physiological_sensi0.65371411
112MP0010678_abnormal_skin_adnexa0.65224276
113MP0005410_abnormal_fertilization0.64596107
114MP0002095_abnormal_skin_pigmentation0.64298176
115MP0000751_myopathy0.63502024
116MP0002249_abnormal_larynx_morphology0.63150884
117MP0003119_abnormal_digestive_system0.62801020
118MP0001963_abnormal_hearing_physiology0.62243174
119MP0005389_reproductive_system_phenotype0.59657512
120MP0010769_abnormal_survival0.58873111
121MP0004742_abnormal_vestibular_system0.58133229
122MP0003938_abnormal_ear_development0.57865528
123MP0003632_abnormal_nervous_system0.57754169
124MP0010770_preweaning_lethality0.57160213
125MP0002082_postnatal_lethality0.57160213
126MP0004215_abnormal_myocardial_fiber0.57091621
127MP0002081_perinatal_lethality0.56611632
128MP0005248_abnormal_Harderian_gland0.55936801

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.37831401
2Focal motor seizures (HP:0011153)5.37105205
3Focal seizures (HP:0007359)4.86325981
4Visual hallucinations (HP:0002367)4.73021042
5Epileptic encephalopathy (HP:0200134)4.58579681
6Febrile seizures (HP:0002373)4.28869782
7Abnormality of the lower motor neuron (HP:0002366)4.18123549
8Atonic seizures (HP:0010819)3.87778852
9Hyperventilation (HP:0002883)3.70092640
10Hepatoblastoma (HP:0002884)3.50666902
11Progressive cerebellar ataxia (HP:0002073)3.43737170
12Amblyopia (HP:0000646)3.40140865
13Ankle clonus (HP:0011448)3.39366981
14Amyotrophic lateral sclerosis (HP:0007354)3.39065697
15Supranuclear gaze palsy (HP:0000605)3.34404261
16Dialeptic seizures (HP:0011146)3.33455840
17Absence seizures (HP:0002121)3.29508318
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.27719860
19Degeneration of the lateral corticospinal tracts (HP:0002314)3.27719860
20Truncal obesity (HP:0001956)3.24284982
21Action tremor (HP:0002345)3.16856292
22Generalized tonic-clonic seizures (HP:0002069)3.13463581
23Drooling (HP:0002307)2.97687553
24Excessive salivation (HP:0003781)2.97687553
25Volvulus (HP:0002580)2.95307369
26Depression (HP:0000716)2.90240084
27Broad-based gait (HP:0002136)2.84747428
28Poor eye contact (HP:0000817)2.84365868
29Hemiparesis (HP:0001269)2.83138133
30Oligodactyly (hands) (HP:0001180)2.76938540
31Mutism (HP:0002300)2.69900172
32Neurofibrillary tangles (HP:0002185)2.64575958
33Widely spaced teeth (HP:0000687)2.64413249
34Impaired social interactions (HP:0000735)2.59901535
35Abnormal social behavior (HP:0012433)2.59901535
36Truncal ataxia (HP:0002078)2.59395612
37Impaired vibration sensation in the lower limbs (HP:0002166)2.57878792
38Tubulointerstitial nephritis (HP:0001970)2.54236706
39Abnormality of the corticospinal tract (HP:0002492)2.52920470
40Urinary bladder sphincter dysfunction (HP:0002839)2.50910537
41Epileptiform EEG discharges (HP:0011182)2.50837043
42Genetic anticipation (HP:0003743)2.50613311
43Absent speech (HP:0001344)2.48465408
44EEG with generalized epileptiform discharges (HP:0011198)2.48415346
45Failure to thrive in infancy (HP:0001531)2.47934552
46Papilledema (HP:0001085)2.45956868
47Limb dystonia (HP:0002451)2.45509416
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.42897728
49Neoplasm of the heart (HP:0100544)2.42464300
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.40932111
51Hypsarrhythmia (HP:0002521)2.39716428
52Heterotopia (HP:0002282)2.37434928
53Paraplegia (HP:0010550)2.37065719
54Inability to walk (HP:0002540)2.35903756
55Dysdiadochokinesis (HP:0002075)2.35544426
56Agitation (HP:0000713)2.35305655
57Spastic gait (HP:0002064)2.35259061
58Spastic paraplegia (HP:0001258)2.33797855
59Gaze-evoked nystagmus (HP:0000640)2.32162009
60Bilateral microphthalmos (HP:0007633)2.30781751
61Impaired smooth pursuit (HP:0007772)2.29981013
62Neonatal hypoglycemia (HP:0001998)2.28866102
63Nephronophthisis (HP:0000090)2.25357395
64Anxiety (HP:0000739)2.25110542
65Stereotypic behavior (HP:0000733)2.25019218
66Urinary urgency (HP:0000012)2.24674988
67Abnormal eating behavior (HP:0100738)2.24663318
68Pachygyria (HP:0001302)2.22145366
69Progressive inability to walk (HP:0002505)2.21053892
70Abnormality of midbrain morphology (HP:0002418)2.18947284
71Molar tooth sign on MRI (HP:0002419)2.18947284
72Apathy (HP:0000741)2.18766387
73Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18333078
74Postural instability (HP:0002172)2.15761861
75Abnormality of ocular smooth pursuit (HP:0000617)2.14933050
76Open mouth (HP:0000194)2.14613987
77Lower limb muscle weakness (HP:0007340)2.12598863
78Protruding tongue (HP:0010808)2.11513890
79Morphological abnormality of the pyramidal tract (HP:0002062)2.09033328
80Torticollis (HP:0000473)2.08733726
81Megalencephaly (HP:0001355)2.07299735
82Generalized hypotonia (HP:0001290)2.07069574
83Bradykinesia (HP:0002067)2.06314204
84Dysmetria (HP:0001310)2.06178141
85Inappropriate behavior (HP:0000719)2.06058643
86Hypoplastic iliac wings (HP:0002866)2.05749950
87Abnormality of the renal medulla (HP:0100957)2.05420699
88Hypoplasia of the corpus callosum (HP:0002079)2.03514143
89Lissencephaly (HP:0001339)2.03310133
90Prolonged QT interval (HP:0001657)2.03007269
91Hyperkalemia (HP:0002153)2.02399300
92Hypoplastic ischia (HP:0003175)2.01335588
93Aplasia/Hypoplasia of the brainstem (HP:0007362)2.01235725
94Hypoplasia of the brainstem (HP:0002365)2.01235725
95Macroorchidism (HP:0000053)2.00554807
96Clumsiness (HP:0002312)1.99296650
97Diminished motivation (HP:0000745)1.98221146
98Medial flaring of the eyebrow (HP:0010747)1.97161156
99Insomnia (HP:0100785)1.96488963
100Polyphagia (HP:0002591)1.94853384
101Cerebellar dysplasia (HP:0007033)1.94851888
102Congenital primary aphakia (HP:0007707)1.93856716
103Focal dystonia (HP:0004373)1.91685551
104Generalized myoclonic seizures (HP:0002123)1.91388946
105Diplopia (HP:0000651)1.89708467
106Abnormality of binocular vision (HP:0011514)1.89708467
107Clonus (HP:0002169)1.89644602
108Nephrogenic diabetes insipidus (HP:0009806)1.88855225
109Type II lissencephaly (HP:0007260)1.88546512
110Abnormality of the astrocytes (HP:0100707)1.88522659
111Astrocytoma (HP:0009592)1.88522659
112Tented upper lip vermilion (HP:0010804)1.88299058
113Abnormality of the fingertips (HP:0001211)1.87518946
114Status epilepticus (HP:0002133)1.86600026
115Abnormality of the aortic arch (HP:0012303)1.86030742
116Fetal akinesia sequence (HP:0001989)1.85178694
117Impaired vibratory sensation (HP:0002495)1.85118130
118Pheochromocytoma (HP:0002666)1.84580254
119Abnormality of salivation (HP:0100755)1.84125922
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83059154
121Horizontal nystagmus (HP:0000666)1.83015048
122Gait imbalance (HP:0002141)1.82871454
123Exotropia (HP:0000577)1.82808253
124Abnormal EKG (HP:0003115)1.82286610
125Tetraplegia (HP:0002445)1.81849254
126Poor coordination (HP:0002370)1.81217409
127Syncope (HP:0001279)1.80889582
128Abnormality of the ischium (HP:0003174)1.80550167
129Impaired pain sensation (HP:0007328)1.80036198
130Abnormality of pain sensation (HP:0010832)1.80036198
131Highly arched eyebrow (HP:0002553)1.79695191
132Thyroid-stimulating hormone excess (HP:0002925)1.79243312
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78003059
134Specific learning disability (HP:0001328)1.77889951
135Thick eyebrow (HP:0000574)1.77764395
136Scanning speech (HP:0002168)1.77095707
137Neuronal loss in central nervous system (HP:0002529)1.76727050
138Insidious onset (HP:0003587)1.76724817
139Termporal pattern (HP:0011008)1.76724817
140Resting tremor (HP:0002322)1.76721887
141Atrophy/Degeneration involving motor neurons (HP:0007373)1.75451897
142Hyperinsulinemic hypoglycemia (HP:0000825)1.74875574
143Intellectual disability, severe (HP:0010864)1.74610687
144Broad distal phalanx of finger (HP:0009836)1.74076271
145Spastic tetraparesis (HP:0001285)1.73704904
146Obsessive-compulsive behavior (HP:0000722)1.71214113
147Shoulder girdle muscle weakness (HP:0003547)1.68503373
148Macroglossia (HP:0000158)1.65743110
149Metaphyseal cupping (HP:0003021)1.64528640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.63786735
2NTRK33.85563885
3MAP3K93.46636868
4EPHA43.10270162
5MAP3K42.79647765
6GRK52.69787683
7MINK12.53987663
8DAPK22.37990017
9NTRK22.36840368
10MAP2K72.33537702
11MAP2K42.13694413
12NTRK12.05914543
13PAK62.00190520
14KSR11.85741011
15SIK21.85065735
16MAPK131.82783107
17TYRO31.74309041
18PRKD31.73298500
19FRK1.66050658
20KSR21.59921195
21PRPF4B1.58586383
22CASK1.46418030
23DAPK11.45147143
24CDK51.44858112
25CSF1R1.39514164
26MET1.39357315
27CAMKK11.39133525
28SIK31.37842386
29MARK21.32497799
30PHKG21.30890650
31PHKG11.30890650
32MAP3K121.29285618
33UHMK11.21868861
34CDK121.21168532
35PRKCG1.10910945
36FGR1.09060989
37TRIB31.06345511
38TNK21.03931316
39MAP3K101.03466808
40TNIK1.01031739
41DYRK1A0.98815651
42BMX0.95857928
43MAP3K20.95574189
44INSRR0.94866359
45PDGFRB0.94003256
46GRK60.92468830
47SGK2230.91427145
48SGK4940.91427145
49DYRK20.90220609
50TAOK10.89755522
51STK380.89501719
52CAMKK20.87575351
53LATS20.87226038
54RIPK40.87002010
55ERBB30.85026949
56MAP2K20.83744098
57PAK30.83438438
58PLK20.83355293
59CAMK40.83239313
60CDK180.82821924
61DYRK1B0.82172519
62ADRBK20.81768877
63CCNB10.80931969
64TAOK30.80721967
65SGK20.80190681
66WNK10.79878579
67MAPK150.79359770
68CDK150.76941760
69RET0.76920961
70WNK30.76571761
71OXSR10.76039133
72MAPK70.76037499
73HIPK20.75452606
74CDK140.75019671
75PRKCH0.73139430
76EPHA30.72984876
77CSNK1G20.72731346
78CAMK10.72143424
79SGK30.71799743
80BRD40.71582382
81MAP3K60.71408528
82FES0.69291006
83CDK11A0.67442779
84STK110.66219095
85CDK190.65574718
86CAMK2A0.63500453
87ARAF0.61362708
88PNCK0.60725554
89ALK0.60618754
90MAP3K70.60171048
91GRK10.59596446
92GRK70.59402062
93RPS6KA20.59165404
94MAPK120.58362101
95PRKCZ0.56595687
96MAP2K60.56533260
97PKN10.55514607
98CDK30.54188995
99CAMK1G0.53817082
100DDR20.53777891
101ADRBK10.52931096
102PDGFRA0.52695290
103RPS6KA60.52588981
104BMPR20.50031822
105SIK10.48565087
106RPS6KC10.48299494
107RPS6KL10.48299494
108MATK0.47941771
109SGK10.47540221
110RPS6KA30.46452959
111MAPK100.46450347
112MAPK30.45142893
113PDPK10.44074652
114RPS6KB10.43597587
115PDK10.42848852
116MAP3K130.42634278
117BLK0.40442044
118PINK10.39688473
119ERBB20.39355515
120CDC42BPA0.39310508
121BMPR1B0.38741936
122SYK0.38191928
123FGFR30.37952027
124GSK3B0.37706504
125CAMK1D0.37536057
126MTOR0.37145977
127CHUK0.36945755
128RAF10.36882017
129FYN0.36398582
130RIPK10.36354904
131PTK2B0.34855929
132CAMK2B0.34543507
133MAPK10.33956464
134MAPK80.33710193
135MAP3K10.33001463
136PRKAA10.32610924
137ICK0.32085803

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.14173111
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04562075
3Olfactory transduction_Homo sapiens_hsa047402.67972995
4Circadian entrainment_Homo sapiens_hsa047132.58318869
5GABAergic synapse_Homo sapiens_hsa047272.57565317
6Glutamatergic synapse_Homo sapiens_hsa047242.46486728
7Long-term potentiation_Homo sapiens_hsa047202.44723748
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39003875
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30700131
10Morphine addiction_Homo sapiens_hsa050322.27162049
11Amphetamine addiction_Homo sapiens_hsa050312.22575614
12Dopaminergic synapse_Homo sapiens_hsa047282.21967678
13Insulin secretion_Homo sapiens_hsa049112.17100894
14Cholinergic synapse_Homo sapiens_hsa047251.91413219
15Taste transduction_Homo sapiens_hsa047421.83462282
16Salivary secretion_Homo sapiens_hsa049701.82687842
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72785740
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70459851
19Serotonergic synapse_Homo sapiens_hsa047261.67132302
20Renin secretion_Homo sapiens_hsa049241.64526962
21Oxytocin signaling pathway_Homo sapiens_hsa049211.63192288
22Long-term depression_Homo sapiens_hsa047301.62995624
23Cocaine addiction_Homo sapiens_hsa050301.60534783
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58185892
25Gastric acid secretion_Homo sapiens_hsa049711.52187712
26GnRH signaling pathway_Homo sapiens_hsa049121.45039571
27Type II diabetes mellitus_Homo sapiens_hsa049301.44439108
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40877377
29Calcium signaling pathway_Homo sapiens_hsa040201.39383227
30Gap junction_Homo sapiens_hsa045401.36274144
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34467549
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29385903
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26701939
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25497543
35Phototransduction_Homo sapiens_hsa047441.24468412
36Axon guidance_Homo sapiens_hsa043601.23820801
37cAMP signaling pathway_Homo sapiens_hsa040241.23806894
38Glioma_Homo sapiens_hsa052141.20170746
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16658457
40ErbB signaling pathway_Homo sapiens_hsa040121.14896126
41Estrogen signaling pathway_Homo sapiens_hsa049151.13999280
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06473825
43Notch signaling pathway_Homo sapiens_hsa043301.02896683
44Melanogenesis_Homo sapiens_hsa049160.99103154
45Collecting duct acid secretion_Homo sapiens_hsa049660.99018083
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.97703852
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.94238474
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.93586669
49T cell receptor signaling pathway_Homo sapiens_hsa046600.92746267
50mTOR signaling pathway_Homo sapiens_hsa041500.92518760
51B cell receptor signaling pathway_Homo sapiens_hsa046620.92310672
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90492608
53Endometrial cancer_Homo sapiens_hsa052130.89867478
54ABC transporters_Homo sapiens_hsa020100.89844395
55Acute myeloid leukemia_Homo sapiens_hsa052210.86781276
56Ether lipid metabolism_Homo sapiens_hsa005650.86520224
57Choline metabolism in cancer_Homo sapiens_hsa052310.86454220
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84828806
59Oocyte meiosis_Homo sapiens_hsa041140.84147557
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82224659
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80395360
62VEGF signaling pathway_Homo sapiens_hsa043700.79999197
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78192832
64MAPK signaling pathway_Homo sapiens_hsa040100.77174142
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75398230
66Vibrio cholerae infection_Homo sapiens_hsa051100.75222872
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.75182198
68Dorso-ventral axis formation_Homo sapiens_hsa043200.74456088
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.72135669
70Colorectal cancer_Homo sapiens_hsa052100.71631557
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71261070
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70355289
73Non-small cell lung cancer_Homo sapiens_hsa052230.69934785
74Osteoclast differentiation_Homo sapiens_hsa043800.68171032
75Glucagon signaling pathway_Homo sapiens_hsa049220.67134207
76Dilated cardiomyopathy_Homo sapiens_hsa054140.67105815
77Cardiac muscle contraction_Homo sapiens_hsa042600.66827194
78Inositol phosphate metabolism_Homo sapiens_hsa005620.66779917
79Pancreatic secretion_Homo sapiens_hsa049720.66532058
80Ras signaling pathway_Homo sapiens_hsa040140.65846420
81Lysine degradation_Homo sapiens_hsa003100.64991995
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64412341
83Linoleic acid metabolism_Homo sapiens_hsa005910.64369140
84FoxO signaling pathway_Homo sapiens_hsa040680.63693073
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63055373
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62166892
87Insulin signaling pathway_Homo sapiens_hsa049100.61725660
88Wnt signaling pathway_Homo sapiens_hsa043100.61694054
89Thyroid hormone synthesis_Homo sapiens_hsa049180.60732587
90Rap1 signaling pathway_Homo sapiens_hsa040150.60633551
91TNF signaling pathway_Homo sapiens_hsa046680.60293508
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59086993
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.58926682
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58571552
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58196899
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57627732
97Circadian rhythm_Homo sapiens_hsa047100.56308300
98Endocytosis_Homo sapiens_hsa041440.55314639
99Alcoholism_Homo sapiens_hsa050340.54411844
100Platelet activation_Homo sapiens_hsa046110.54358425
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53765936
102Tuberculosis_Homo sapiens_hsa051520.53057793
103Renal cell carcinoma_Homo sapiens_hsa052110.52511857
104Insulin resistance_Homo sapiens_hsa049310.52301907
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51665761
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.50556339
107Prolactin signaling pathway_Homo sapiens_hsa049170.50476891
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49340560
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45823634
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.43517481
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43282594
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41608235
113Ovarian steroidogenesis_Homo sapiens_hsa049130.41154465
114Prion diseases_Homo sapiens_hsa050200.41092358
115Type I diabetes mellitus_Homo sapiens_hsa049400.39856889
116AMPK signaling pathway_Homo sapiens_hsa041520.39259817
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38427079
118Hedgehog signaling pathway_Homo sapiens_hsa043400.34638670
119Chemokine signaling pathway_Homo sapiens_hsa040620.32875503
120Regulation of autophagy_Homo sapiens_hsa041400.30370424
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30279468
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29277782

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