PARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of proline to tRNA molecules. Mutations have been found in this gene in some patients with Alpers syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.33607917
2DNA strand elongation (GO:0022616)5.22974763
3telomere maintenance via semi-conservative replication (GO:0032201)5.00262682
4DNA unwinding involved in DNA replication (GO:0006268)4.89726433
5DNA replication initiation (GO:0006270)4.89417939
6nucleobase biosynthetic process (GO:0046112)4.75100726
7purine nucleobase biosynthetic process (GO:0009113)4.53976726
8IMP biosynthetic process (GO:0006188)4.52090808
9DNA deamination (GO:0045006)4.48326860
10L-serine metabolic process (GO:0006563)4.37161259
11formation of translation preinitiation complex (GO:0001731)4.34403199
12telomere maintenance via recombination (GO:0000722)4.28244019
13telomere maintenance via telomere lengthening (GO:0010833)4.17736908
14maturation of 5.8S rRNA (GO:0000460)4.12953282
15kinetochore organization (GO:0051383)4.12170923
16viral mRNA export from host cell nucleus (GO:0046784)4.09339992
17folic acid-containing compound biosynthetic process (GO:0009396)4.08326489
18nucleotide-excision repair, DNA gap filling (GO:0006297)4.01170340
19ribosomal small subunit assembly (GO:0000028)3.99649992
20kinetochore assembly (GO:0051382)3.99442009
21mitotic recombination (GO:0006312)3.96730679
22IMP metabolic process (GO:0046040)3.89602131
23DNA replication checkpoint (GO:0000076)3.85048460
24protein localization to chromosome, centromeric region (GO:0071459)3.74043083
25somatic diversification of immune receptors via somatic mutation (GO:0002566)3.72169136
26somatic hypermutation of immunoglobulin genes (GO:0016446)3.72169136
27maturation of SSU-rRNA (GO:0030490)3.69046506
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.67313271
29regulation of mitochondrial translation (GO:0070129)3.66004951
30pseudouridine synthesis (GO:0001522)3.65299071
31ribosome biogenesis (GO:0042254)3.60859138
32rRNA processing (GO:0006364)3.55270716
33mitotic metaphase plate congression (GO:0007080)3.48146174
34folic acid metabolic process (GO:0046655)3.47976414
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44037920
36negative regulation of ligase activity (GO:0051352)3.43123490
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43123490
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42987892
39rRNA metabolic process (GO:0016072)3.38774841
40L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.38528088
41establishment of viral latency (GO:0019043)3.37815115
42telomere organization (GO:0032200)3.37297908
43* tRNA aminoacylation for protein translation (GO:0006418)3.36887658
44replication fork processing (GO:0031297)3.36843211
45negative regulation of histone methylation (GO:0031061)3.36026628
46regulation of helicase activity (GO:0051095)3.35755563
47telomere maintenance (GO:0000723)3.35198542
48CENP-A containing nucleosome assembly (GO:0034080)3.34367672
49DNA replication-dependent nucleosome assembly (GO:0006335)3.32934822
50DNA replication-dependent nucleosome organization (GO:0034723)3.32934822
51chromatin remodeling at centromere (GO:0031055)3.32020108
52cullin deneddylation (GO:0010388)3.31568562
53regulation of histone H3-K9 methylation (GO:0051570)3.30853624
54ribosomal large subunit biogenesis (GO:0042273)3.30554065
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.28997359
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27634734
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27634734
58* tRNA aminoacylation (GO:0043039)3.26814729
59* amino acid activation (GO:0043038)3.26814729
60mitotic sister chromatid segregation (GO:0000070)3.26619360
61ribonucleoprotein complex biogenesis (GO:0022613)3.24886667
62protein localization to kinetochore (GO:0034501)3.24436305
63regulation of double-strand break repair via homologous recombination (GO:0010569)3.23698832
64spliceosomal snRNP assembly (GO:0000387)3.23449382
65DNA replication-independent nucleosome assembly (GO:0006336)3.23431311
66DNA replication-independent nucleosome organization (GO:0034724)3.23431311
67mitotic nuclear envelope disassembly (GO:0007077)3.22095006
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20416278
69mismatch repair (GO:0006298)3.19935207
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19408956
71nuclear pore complex assembly (GO:0051292)3.18814124
72DNA duplex unwinding (GO:0032508)3.18670788
73translesion synthesis (GO:0019985)3.16904158
74DNA geometric change (GO:0032392)3.16489359
75negative regulation of chromosome segregation (GO:0051985)3.13833098
76protein deneddylation (GO:0000338)3.12293302
77negative regulation of mitotic sister chromatid separation (GO:2000816)3.10749668
78negative regulation of sister chromatid segregation (GO:0033046)3.10749668
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10749668
80negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10749668
81negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10749668
82positive regulation of chromosome segregation (GO:0051984)3.10563226
83transcription-coupled nucleotide-excision repair (GO:0006283)3.10337427
84regulation of chromosome segregation (GO:0051983)3.10211612
85DNA synthesis involved in DNA repair (GO:0000731)3.09465358
86DNA damage response, detection of DNA damage (GO:0042769)3.09098947
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08084186
88DNA catabolic process, exonucleolytic (GO:0000738)3.06113814
89rRNA modification (GO:0000154)3.05288250
90spindle checkpoint (GO:0031577)3.04818514
91mitotic spindle checkpoint (GO:0071174)3.03266252
92DNA ligation (GO:0006266)3.02495426
93proteasome assembly (GO:0043248)3.02002987
94postreplication repair (GO:0006301)3.01374640
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00715752
96establishment of integrated proviral latency (GO:0075713)3.00539585
97mitotic chromosome condensation (GO:0007076)2.99769704
98metaphase plate congression (GO:0051310)2.97467502
99pteridine-containing compound biosynthetic process (GO:0042559)2.97111211
100cell cycle G1/S phase transition (GO:0044843)2.96991927
101G1/S transition of mitotic cell cycle (GO:0000082)2.96991927
102positive regulation of ligase activity (GO:0051351)2.95572835
103regulation of ubiquitin-protein transferase activity (GO:0051438)2.95548050
104histone arginine methylation (GO:0034969)2.95118993
105regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94971333
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94971333
107mitochondrial RNA metabolic process (GO:0000959)2.94811628
108nuclear pore organization (GO:0006999)2.94687305
109L-methionine salvage (GO:0071267)2.94437283
110L-methionine biosynthetic process (GO:0071265)2.94437283
111amino acid salvage (GO:0043102)2.94437283
112mitotic spindle assembly checkpoint (GO:0007094)2.94399308
113establishment of chromosome localization (GO:0051303)2.94232253
114negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93996962
115serine family amino acid biosynthetic process (GO:0009070)2.93441015
116DNA replication (GO:0006260)2.92216991
117spliceosomal complex assembly (GO:0000245)2.90240522
118nuclear envelope disassembly (GO:0051081)2.90144793
119membrane disassembly (GO:0030397)2.90144793
120ncRNA processing (GO:0034470)2.89842259
121spindle assembly checkpoint (GO:0071173)2.89147807
122regulation of nuclear cell cycle DNA replication (GO:0033262)2.88590859
123ribosome assembly (GO:0042255)2.86963411
124tRNA methylation (GO:0030488)2.86754538
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.86395686
126mRNA splicing, via spliceosome (GO:0000398)2.86395686
127regulation of ligase activity (GO:0051340)2.85493356
128sister chromatid segregation (GO:0000819)2.85419904
129somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85052960
130somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85052960
131isotype switching (GO:0045190)2.85052960
132DNA strand renaturation (GO:0000733)2.84876524
133synapsis (GO:0007129)2.84715423
134RNA splicing, via transesterification reactions (GO:0000375)2.84524442
135translational initiation (GO:0006413)2.83340857
136histone exchange (GO:0043486)2.83104280
137double-strand break repair via nonhomologous end joining (GO:0006303)2.82612842
138non-recombinational repair (GO:0000726)2.82612842
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82145238
140viral transcription (GO:0019083)2.82087380
141regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81909515
142regulation of sister chromatid segregation (GO:0033045)2.80770003
143regulation of mitotic sister chromatid separation (GO:0010965)2.80770003
144regulation of mitotic sister chromatid segregation (GO:0033047)2.80770003
145base-excision repair (GO:0006284)2.80584852
146transcription elongation from RNA polymerase III promoter (GO:0006385)2.80316272
147pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.79899865
148transcription from mitochondrial promoter (GO:0006390)2.78642754
149regulation of spindle organization (GO:0090224)2.76861814
1507-methylguanosine mRNA capping (GO:0006370)2.75443756
151tricarboxylic acid cycle (GO:0006099)2.74443472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.57513646
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.76274617
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.28967013
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89659121
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53878414
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.19014557
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.09227636
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08599342
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00593508
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98948746
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94705556
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88965576
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.85525714
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.84186240
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74278531
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70663760
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.59583768
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47209291
19VDR_23849224_ChIP-Seq_CD4+_Human2.37503757
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33307363
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33108464
22XRN2_22483619_ChIP-Seq_HELA_Human2.30594953
23FOXP3_21729870_ChIP-Seq_TREG_Human2.16655880
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.15894625
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12598074
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09937041
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.08948689
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03372046
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02212520
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99789623
31* GABP_19822575_ChIP-Seq_HepG2_Human1.95028407
32MYC_22102868_ChIP-Seq_BL_Human1.94724412
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90811340
34DCP1A_22483619_ChIP-Seq_HELA_Human1.90686550
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89151632
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88484949
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85945255
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84454551
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81129631
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77130938
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76312200
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.74793844
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73744555
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73408926
45TTF2_22483619_ChIP-Seq_HELA_Human1.70503571
46CIITA_25753668_ChIP-Seq_RAJI_Human1.69424685
47AR_21909140_ChIP-Seq_LNCAP_Human1.65690666
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63255435
49* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61933774
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57224305
51* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55652390
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55617017
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54043777
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50865224
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.50088238
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45410599
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45171238
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44429585
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44267150
60* ELK1_19687146_ChIP-ChIP_HELA_Human1.43714476
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43710042
62KDM5A_27292631_Chip-Seq_BREAST_Human1.42791216
63* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37063724
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.35694920
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27860080
66* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26093362
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26014588
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19703891
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18138762
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17835295
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16747351
72* NOTCH1_21737748_ChIP-Seq_TLL_Human1.16114607
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14244376
74VDR_21846776_ChIP-Seq_THP-1_Human1.12324508
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12115363
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10254971
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09334894
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07954787
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05987674
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05945852
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05329941
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.04408558
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02394882
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99346630
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98906969
86TFEB_21752829_ChIP-Seq_HELA_Human0.97736307
87SOX17_20123909_ChIP-Seq_XEN_Mouse0.97637191
88MYC_18940864_ChIP-ChIP_HL60_Human0.96660433
89SPI1_23547873_ChIP-Seq_NB4_Human0.95463164
90TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94453218
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.94047522
92ZNF263_19887448_ChIP-Seq_K562_Human0.93078997
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92861715
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92741724
95CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92550404
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92032457
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91732771
98* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91561660
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88695461
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.87879068
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85630372
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85129110
103ELK1_22589737_ChIP-Seq_MCF10A_Human0.84703976
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83479476
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83479476
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83479476
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83203092
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82757305
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82225738
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82063649
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81971691
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81751461
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80819816
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80734181
115SALL1_21062744_ChIP-ChIP_HESCs_Human0.80445389
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79369991
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79334355
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77294846
119OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74898677
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.70896277
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.70593321
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.70135262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.48169391
2MP0003693_abnormal_embryo_hatching4.70023252
3MP0003111_abnormal_nucleus_morphology4.23352580
4MP0004957_abnormal_blastocyst_morpholog3.88395048
5MP0003077_abnormal_cell_cycle3.83286228
6MP0002396_abnormal_hematopoietic_system3.59672566
7MP0008057_abnormal_DNA_replication3.44804738
8MP0008058_abnormal_DNA_repair3.37967847
9MP0008877_abnormal_DNA_methylation2.92960655
10MP0008007_abnormal_cellular_replicative2.92795766
11MP0003123_paternal_imprinting2.87074845
12MP0003806_abnormal_nucleotide_metabolis2.81034088
13MP0004808_abnormal_hematopoietic_stem2.43243893
14MP0008932_abnormal_embryonic_tissue2.34841520
15MP0003763_abnormal_thymus_physiology2.30256001
16MP0003941_abnormal_skin_development2.23098426
17MP0003787_abnormal_imprinting2.22451131
18MP0002132_abnormal_respiratory_system2.15618273
19MP0008260_abnormal_autophagy2.12547834
20MP0003786_premature_aging2.03849712
21MP0000350_abnormal_cell_proliferation1.97641420
22MP0003121_genomic_imprinting1.93296991
23MP0006292_abnormal_olfactory_placode1.86131307
24MP0001730_embryonic_growth_arrest1.77638982
25MP0000490_abnormal_crypts_of1.76690936
26MP0003315_abnormal_perineum_morphology1.65418337
27MP0003718_maternal_effect1.62199118
28MP0001545_abnormal_hematopoietic_system1.61674873
29MP0005397_hematopoietic_system_phenotyp1.61674873
30MP0002398_abnormal_bone_marrow1.58051752
31MP0010030_abnormal_orbit_morphology1.55281767
32MP0003567_abnormal_fetal_cardiomyocyte1.53804503
33MP0010234_abnormal_vibrissa_follicle1.53355655
34MP0000313_abnormal_cell_death1.46982231
35MP0002080_prenatal_lethality1.45613397
36MP0001672_abnormal_embryogenesis/_devel1.45569370
37MP0005380_embryogenesis_phenotype1.45569370
38MP0004233_abnormal_muscle_weight1.44524017
39MP0000703_abnormal_thymus_morphology1.43022635
40MP0000689_abnormal_spleen_morphology1.42111424
41MP0001697_abnormal_embryo_size1.42025390
42MP0009672_abnormal_birth_weight1.41738737
43MP0009333_abnormal_splenocyte_physiolog1.39236623
44MP0003984_embryonic_growth_retardation1.36225242
45MP0002019_abnormal_tumor_incidence1.33463684
46MP0002722_abnormal_immune_system1.33113160
47MP0002088_abnormal_embryonic_growth/wei1.30355503
48MP0010352_gastrointestinal_tract_polyps1.29571407
49MP0002160_abnormal_reproductive_system1.28386859
50MP0006035_abnormal_mitochondrial_morpho1.27825349
51MP0010307_abnormal_tumor_latency1.23664474
52MP0006036_abnormal_mitochondrial_physio1.22132012
53MP0002429_abnormal_blood_cell1.19731319
54MP0004197_abnormal_fetal_growth/weight/1.13141360
55MP0002697_abnormal_eye_size1.09690571
56MP0002085_abnormal_embryonic_tissue1.09425869
57MP0000716_abnormal_immune_system1.09137800
58MP0003943_abnormal_hepatobiliary_system1.09060212
59MP0005395_other_phenotype1.08068900
60MP0002086_abnormal_extraembryonic_tissu1.07385399
61MP0000647_abnormal_sebaceous_gland1.06606619
62MP0002653_abnormal_ependyma_morphology1.06518677
63MP0001835_abnormal_antigen_presentation1.05892271
64MP0010678_abnormal_skin_adnexa1.05358420
65MP0004147_increased_porphyrin_level1.04600019
66MP0002210_abnormal_sex_determination1.03845549
67MP0001764_abnormal_homeostasis1.03175549
68MP0005501_abnormal_skin_physiology1.02297318
69MP0008789_abnormal_olfactory_epithelium1.01434373
70MP0001346_abnormal_lacrimal_gland1.00689215
71MP0002233_abnormal_nose_morphology0.99907919
72MP0003937_abnormal_limbs/digits/tail_de0.98106479
73MP0005389_reproductive_system_phenotype0.97662188
74MP0002163_abnormal_gland_morphology0.96223159
75MP0001661_extended_life_span0.95319992
76MP0003136_yellow_coat_color0.95255168
77MP0001800_abnormal_humoral_immune0.94888984
78MP0005174_abnormal_tail_pigmentation0.94343504
79MP0002269_muscular_atrophy0.92435854
80MP0005075_abnormal_melanosome_morpholog0.92255758
81MP0001145_abnormal_male_reproductive0.91559109
82MP0001529_abnormal_vocalization0.88976162
83MP0001286_abnormal_eye_development0.88412498
84MP0002090_abnormal_vision0.88252155
85MP0003656_abnormal_erythrocyte_physiolo0.88200851
86MP0002084_abnormal_developmental_patter0.87530588
87MP0002102_abnormal_ear_morphology0.86925181
88MP0000015_abnormal_ear_pigmentation0.85800608
89MP0003890_abnormal_embryonic-extraembry0.85307617
90MP0002111_abnormal_tail_morphology0.84173284
91MP0009703_decreased_birth_body0.83781398
92MP0000358_abnormal_cell_content/0.82494022
93MP0005499_abnormal_olfactory_system0.81788892
94MP0005394_taste/olfaction_phenotype0.81788892
95MP0003221_abnormal_cardiomyocyte_apopto0.81341782
96MP0000685_abnormal_immune_system0.80816981
97MP0001293_anophthalmia0.80789002
98MP0003119_abnormal_digestive_system0.80594334
99MP0000383_abnormal_hair_follicle0.80210633
100MP0002092_abnormal_eye_morphology0.79335570
101MP0002095_abnormal_skin_pigmentation0.79096794
102MP0001119_abnormal_female_reproductive0.78627353
103MP0003122_maternal_imprinting0.78356909
104MP0002254_reproductive_system_inflammat0.77521171
105MP0000749_muscle_degeneration0.77477132
106MP0002161_abnormal_fertility/fecundity0.76928145
107MP0001188_hyperpigmentation0.76739320
108MP0005384_cellular_phenotype0.76219612
109MP0002089_abnormal_postnatal_growth/wei0.75640995
110MP0004133_heterotaxia0.75532781
111MP0006054_spinal_hemorrhage0.75421042
112MP0005257_abnormal_intraocular_pressure0.75322267
113MP0003699_abnormal_female_reproductive0.75089141
114MP0003186_abnormal_redox_activity0.75007521
115MP0002420_abnormal_adaptive_immunity0.73599405
116MP0000653_abnormal_sex_gland0.73496344
117MP0009379_abnormal_foot_pigmentation0.72424580
118MP0003698_abnormal_male_reproductive0.71896523
119MP0009697_abnormal_copulation0.70910619
120MP0005671_abnormal_response_to0.70821211
121MP0000467_abnormal_esophagus_morphology0.70757324
122MP0001819_abnormal_immune_cell0.70646842
123MP0003755_abnormal_palate_morphology0.69189850
124MP0001929_abnormal_gametogenesis0.68398648
125MP0006072_abnormal_retinal_apoptosis0.68249759
126MP0005451_abnormal_body_composition0.68221668
127MP0003646_muscle_fatigue0.67250545
128MP0002452_abnormal_antigen_presenting0.66546125
129MP0002938_white_spotting0.65812462
130MP0002723_abnormal_immune_serum0.64946615
131MP0001485_abnormal_pinna_reflex0.64120303
132MP0000566_synostosis0.64066759
133MP0001919_abnormal_reproductive_system0.61575053
134MP0000762_abnormal_tongue_morphology0.61489956
135MP0000858_altered_metastatic_potential0.61373033
136MP0008995_early_reproductive_senescence0.60658506
137MP0005621_abnormal_cell_physiology0.60358712
138MP0002796_impaired_skin_barrier0.60174862
139MP0001986_abnormal_taste_sensitivity0.60150301
140MP0001348_abnormal_lacrimal_gland0.58022576
141MP0000598_abnormal_liver_morphology0.56621842

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.54095081
2Abnormality of the heme biosynthetic pathway (HP:0010472)4.34718337
3Colon cancer (HP:0003003)3.95107164
4Selective tooth agenesis (HP:0001592)3.83354285
5Abnormal number of erythroid precursors (HP:0012131)3.82669324
6Cerebral hypomyelination (HP:0006808)3.76261924
7Microvesicular hepatic steatosis (HP:0001414)3.64704363
8IgM deficiency (HP:0002850)3.58840470
9Abnormality of cells of the erythroid lineage (HP:0012130)3.56274868
10Breast hypoplasia (HP:0003187)3.43114754
11Thrombocytosis (HP:0001894)3.28201269
12Multiple enchondromatosis (HP:0005701)3.27909469
13Abnormal gallbladder physiology (HP:0012438)3.19514570
14Cholecystitis (HP:0001082)3.19514570
15Abnormality of the labia minora (HP:0012880)3.17494241
16Microglossia (HP:0000171)3.15681238
17Abnormality of glycolysis (HP:0004366)3.10120877
18Abnormal number of incisors (HP:0011064)3.07569867
19Increased serum pyruvate (HP:0003542)3.06986875
20Hyperglycinemia (HP:0002154)3.04149954
21Aplastic anemia (HP:0001915)3.03419698
22Degeneration of anterior horn cells (HP:0002398)2.95509712
23Abnormality of the anterior horn cell (HP:0006802)2.95509712
24Acute encephalopathy (HP:0006846)2.94619810
25Amaurosis fugax (HP:0100576)2.92623730
26Reticulocytopenia (HP:0001896)2.87002779
27Patellar aplasia (HP:0006443)2.86322933
28Rough bone trabeculation (HP:0100670)2.84055069
29Agnosia (HP:0010524)2.81027968
30Acute necrotizing encephalopathy (HP:0006965)2.80093904
31Abnormal mitochondria in muscle tissue (HP:0008316)2.78140820
32Supernumerary spleens (HP:0009799)2.76964268
33Aplasia/Hypoplasia of the patella (HP:0006498)2.74419019
34Carpal bone hypoplasia (HP:0001498)2.68690521
35B lymphocytopenia (HP:0010976)2.64739101
36Abnormality of B cell number (HP:0010975)2.64739101
37Acute lymphatic leukemia (HP:0006721)2.63500763
38Increased hepatocellular lipid droplets (HP:0006565)2.63427594
39Myelodysplasia (HP:0002863)2.61684112
40Abnormality of chromosome stability (HP:0003220)2.61268768
41Muscle fiber atrophy (HP:0100295)2.60277931
42Rhabdomyosarcoma (HP:0002859)2.58051573
43Medulloblastoma (HP:0002885)2.55488245
44Oral leukoplakia (HP:0002745)2.55054112
45Premature graying of hair (HP:0002216)2.54206423
46Increased CSF lactate (HP:0002490)2.50783684
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.49798044
48Ependymoma (HP:0002888)2.48588343
49Cellular immunodeficiency (HP:0005374)2.47539706
50Median cleft lip (HP:0000161)2.45720127
51Unsteady gait (HP:0002317)2.44961276
52Type 2 muscle fiber atrophy (HP:0003554)2.44814804
53Progressive muscle weakness (HP:0003323)2.44329192
54Cortical dysplasia (HP:0002539)2.42484577
55Panhypogammaglobulinemia (HP:0003139)2.42394670
56Chromsome breakage (HP:0040012)2.41496033
57Short tibia (HP:0005736)2.41310001
58Lymphoma (HP:0002665)2.40576442
59Pallor (HP:0000980)2.39990216
60Lipid accumulation in hepatocytes (HP:0006561)2.36004967
61Pancytopenia (HP:0001876)2.35624187
62Increased intramyocellular lipid droplets (HP:0012240)2.34579708
63Overlapping toe (HP:0001845)2.33558987
64Impulsivity (HP:0100710)2.33465265
65Neoplasm of the pancreas (HP:0002894)2.32959322
66Lactic acidosis (HP:0003128)2.32958826
67Abnormality of the columella (HP:0009929)2.32494337
68Horseshoe kidney (HP:0000085)2.28595396
69Bone marrow hypocellularity (HP:0005528)2.27988510
70Secondary amenorrhea (HP:0000869)2.27532453
71Hepatocellular necrosis (HP:0001404)2.27336915
72Progressive external ophthalmoplegia (HP:0000590)2.26458796
73Abnormality of serine family amino acid metabolism (HP:0010894)2.25440048
74Abnormality of glycine metabolism (HP:0010895)2.25440048
7511 pairs of ribs (HP:0000878)2.23558332
76Duodenal stenosis (HP:0100867)2.23108007
77Small intestinal stenosis (HP:0012848)2.23108007
783-Methylglutaconic aciduria (HP:0003535)2.21020369
79Diastasis recti (HP:0001540)2.20422015
80Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17345401
81Personality changes (HP:0000751)2.17083064
82Mitochondrial inheritance (HP:0001427)2.16867097
83Megaloblastic anemia (HP:0001889)2.16047237
84Exercise intolerance (HP:0003546)2.15628643
85Abnormal biliary tract physiology (HP:0012439)2.14554044
86Bile duct proliferation (HP:0001408)2.14554044
87Entropion (HP:0000621)2.14508726
88Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14158336
89Cerebral edema (HP:0002181)2.14012047
90Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13555772
91Macrocytic anemia (HP:0001972)2.13367283
92Nephroblastoma (Wilms tumor) (HP:0002667)2.11411230
93Meckel diverticulum (HP:0002245)2.11236504
94Abnormality of serum amino acid levels (HP:0003112)2.11013179
95Abnormality of the preputium (HP:0100587)2.10655190
96Abnormal trabecular bone morphology (HP:0100671)2.08896211
97Limb hypertonia (HP:0002509)2.08062341
98Poikiloderma (HP:0001029)2.06834855
99Abnormal lung lobation (HP:0002101)2.06703111
100Increased serum lactate (HP:0002151)2.06355233
101Abnormality of methionine metabolism (HP:0010901)2.05526745
102Abnormality of the duodenum (HP:0002246)2.04146136
103Pelvic girdle muscle weakness (HP:0003749)2.04038452
104Hepatic necrosis (HP:0002605)2.03409638
105Premature ovarian failure (HP:0008209)2.03286836
106Abnormality of the fingertips (HP:0001211)2.01098192
107Increased nuchal translucency (HP:0010880)2.01059121
108Progressive macrocephaly (HP:0004481)2.00751670
109CNS hypomyelination (HP:0003429)2.00485121
110Abnormality of DNA repair (HP:0003254)1.99760658
111Atrophy/Degeneration involving motor neurons (HP:0007373)1.99757996
112Absent thumb (HP:0009777)1.99193859
113Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95386511
114Abnormal spermatogenesis (HP:0008669)1.95024030
115Abnormality of abdominal situs (HP:0011620)1.94630276
116Abdominal situs inversus (HP:0003363)1.94630276
117Recurrent viral infections (HP:0004429)1.94536005
118Pendular nystagmus (HP:0012043)1.94474386
119Abnormality of the ileum (HP:0001549)1.94470105
120Sensory axonal neuropathy (HP:0003390)1.93996739
121Microretrognathia (HP:0000308)1.93544283
122Renal Fanconi syndrome (HP:0001994)1.92965655
123Reduced antithrombin III activity (HP:0001976)1.92441070
124Poor suck (HP:0002033)1.91992990
125Deviation of the thumb (HP:0009603)1.91681188
126Type I transferrin isoform profile (HP:0003642)1.91111455
127Embryonal renal neoplasm (HP:0011794)1.90795805
128Proximal placement of thumb (HP:0009623)1.89737711
129Hypochromic anemia (HP:0001931)1.89443210
130Hypoplasia of the thymus (HP:0000778)1.89426812
131Abnormality of lateral ventricle (HP:0030047)1.89304672
132Self-mutilation (HP:0000742)1.88866609
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88762506
134Abnormal protein N-linked glycosylation (HP:0012347)1.88762506
135Abnormal protein glycosylation (HP:0012346)1.88762506
136Abnormal glycosylation (HP:0012345)1.88762506
137Hyperglycinuria (HP:0003108)1.88618871
138Squamous cell carcinoma (HP:0002860)1.88439548
139Abnormality of alanine metabolism (HP:0010916)1.87622047
140Hyperalaninemia (HP:0003348)1.87622047
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87622047
142Asplenia (HP:0001746)1.86715125
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.86508213
144Sparse eyelashes (HP:0000653)1.85556857
145Hypoplastic pelvis (HP:0008839)1.85369046
146Glioma (HP:0009733)1.84366767
147Hypergonadotropic hypogonadism (HP:0000815)1.83192008
148Chronic otitis media (HP:0000389)1.83162458
149Dyskinesia (HP:0100660)1.83109455
150Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82819580
151Respiratory difficulties (HP:0002880)1.81899066
152Methylmalonic aciduria (HP:0012120)1.81348973
153Hypokinesia (HP:0002375)1.80848005
154Prominent metopic ridge (HP:0005487)1.80834451
155Shoulder girdle muscle weakness (HP:0003547)1.80416304
156Abnormal gallbladder morphology (HP:0012437)1.79542038
157Increased muscle lipid content (HP:0009058)1.79025778
158Cholelithiasis (HP:0001081)1.76090342
159Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75861633
160Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75861633
161Tongue fasciculations (HP:0001308)1.74635145
162Tinnitus (HP:0000360)1.74571778
163Hypoplasia of the pons (HP:0012110)1.74063962
164Neoplasm of the colon (HP:0100273)1.73956882
165Slender long bone (HP:0003100)1.73819014
166Aplasia/Hypoplasia of the tongue (HP:0010295)1.71905786
167Choanal atresia (HP:0000453)1.71778139
168Postnatal microcephaly (HP:0005484)1.71591382
169Neuroblastoma (HP:0003006)1.71571075
170Primitive neuroectodermal tumor (HP:0030065)1.71571075
171Neuroblastic tumors (HP:0004376)1.71571075
172Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.71571075

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.36730854
2BUB13.61317671
3CDC73.44890143
4PBK3.31296245
5EIF2AK12.82520913
6VRK22.79222617
7STK162.70279524
8NME22.50681507
9ACVR1B2.49692049
10NEK12.43880315
11BLK2.28397190
12TSSK62.05485417
13TLK12.03867157
14SRPK12.00058250
15MKNK11.97387720
16BRSK21.97150040
17EIF2AK31.96746205
18MST41.92677948
19TTK1.92047841
20MAP3K101.91940637
21BCKDK1.74868429
22EEF2K1.70963610
23ATR1.68351960
24PASK1.63898770
25PLK11.62709212
26CCNB11.56859906
27VRK11.55513952
28NEK21.53657352
29PLK41.53590821
30NME11.52031523
31CDK41.44966076
32ARAF1.44023050
33MAP4K11.40792665
34FLT31.32472892
35DAPK11.30411653
36PKN21.30377420
37TRIM281.28950125
38DYRK31.27796033
39CAMKK21.26153027
40RPS6KB21.25781044
41CDK71.23063644
42PIM21.18323333
43MKNK21.17616902
44AURKB1.14481919
45BRSK11.12672575
46MAPKAPK51.09115913
47SMG11.08618324
48PIM11.03034920
49WNK31.02433518
50TGFBR11.01915715
51PLK31.01708592
52SIK30.99984573
53CSNK1G10.99802020
54CHEK10.99222728
55GRK60.99061245
56MAP3K80.96423733
57BRAF0.96293448
58MAPKAPK30.93964575
59STK100.93408945
60PAK40.93044739
61CHEK20.93014041
62AURKA0.92426870
63CASK0.91658933
64ZAP700.89427681
65CDK80.89081132
66CLK10.88897978
67AKT30.88785764
68LIMK10.88668757
69MAP3K90.82020939
70BRD40.81998441
71PDK20.80486012
72JAK30.80111303
73CDK20.79919277
74KDR0.79859740
75CDK90.78323538
76EPHA20.78077354
77IRAK30.77443912
78RAF10.77371159
79TESK20.76180859
80PDK30.75221964
81PDK40.75221964
82ZAK0.75006820
83MAP2K30.70623516
84TYK20.69283969
85YES10.68906311
86ATM0.68447972
87STK40.67530530
88CSNK1G20.66892195
89KSR20.63650737
90CSF1R0.62348908
91CSNK2A20.60932465
92CSNK2A10.60472909
93ERBB30.59533917
94TESK10.58618257
95MAP3K60.58525563
96SCYL20.58386500
97CDK190.53370977
98IRAK40.52267138
99TAF10.51151591
100SYK0.50836698
101STK30.50735737
102DYRK20.50110037
103PRKCI0.50066543
104EIF2AK20.49361799
105CDK10.48891003
106MAP4K20.48701050
107TXK0.47507580
108NLK0.47351972
109RPS6KA50.47097918
110BTK0.46386681
111MAPK110.46016688
112KIT0.45174052
113PLK20.43337614
114MET0.43258483
115ADRBK20.43053361
116CSNK1E0.42818239
117CSNK1A1L0.42542997
118CDK11A0.42005363
119MELK0.41843507
120LRRK20.40863306
121NUAK10.40610074
122STK240.40575194
123STK38L0.40223226
124TAOK20.39946627
125CDK120.39660360
126KSR10.37930883
127ERBB40.37141857
128CDK150.36231897
129CDK180.36114278
130ALK0.36099228
131AKT20.35276700
132CDK140.33749839
133PRKD30.31397188
134PAK10.31078700
135RPS6KA40.30792233
136ILK0.30673658
137PRKDC0.28267175
138MUSK0.25509709
139LYN0.24405331
140CSNK1G30.22979258

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.49637352
2Mismatch repair_Homo sapiens_hsa034305.10068084
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.67631100
4Homologous recombination_Homo sapiens_hsa034403.55897706
5Base excision repair_Homo sapiens_hsa034103.38352202
6Spliceosome_Homo sapiens_hsa030403.16092484
7One carbon pool by folate_Homo sapiens_hsa006702.98645789
8Proteasome_Homo sapiens_hsa030502.94660712
9RNA polymerase_Homo sapiens_hsa030202.90931307
10RNA transport_Homo sapiens_hsa030132.78238249
11Nucleotide excision repair_Homo sapiens_hsa034202.76118882
12Ribosome_Homo sapiens_hsa030102.73550756
13Pyrimidine metabolism_Homo sapiens_hsa002402.56003051
14Cell cycle_Homo sapiens_hsa041102.52339665
15* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32454532
16Non-homologous end-joining_Homo sapiens_hsa034502.25764416
17Fatty acid elongation_Homo sapiens_hsa000622.22518669
18Steroid biosynthesis_Homo sapiens_hsa001002.12017950
19Fanconi anemia pathway_Homo sapiens_hsa034601.98108792
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87334184
21RNA degradation_Homo sapiens_hsa030181.80548626
22Basal transcription factors_Homo sapiens_hsa030221.66922189
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46800717
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42706212
25Folate biosynthesis_Homo sapiens_hsa007901.42628891
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.40599122
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40115983
28Purine metabolism_Homo sapiens_hsa002301.39880056
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.36458737
30mRNA surveillance pathway_Homo sapiens_hsa030151.35819283
31Biosynthesis of amino acids_Homo sapiens_hsa012301.34806894
32Primary immunodeficiency_Homo sapiens_hsa053401.32540713
33Propanoate metabolism_Homo sapiens_hsa006401.31986836
34p53 signaling pathway_Homo sapiens_hsa041151.29990344
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29649248
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26608055
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25716125
38Pentose phosphate pathway_Homo sapiens_hsa000301.13257286
39Systemic lupus erythematosus_Homo sapiens_hsa053221.07198346
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.06750177
41Sulfur metabolism_Homo sapiens_hsa009201.00145634
42Epstein-Barr virus infection_Homo sapiens_hsa051690.94936074
43Carbon metabolism_Homo sapiens_hsa012000.90389621
44Fatty acid metabolism_Homo sapiens_hsa012120.90226261
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85964092
46Herpes simplex infection_Homo sapiens_hsa051680.85666174
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85232292
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80876511
49Viral carcinogenesis_Homo sapiens_hsa052030.79289211
50Selenocompound metabolism_Homo sapiens_hsa004500.77909764
51Thyroid cancer_Homo sapiens_hsa052160.77179761
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73064088
53Parkinsons disease_Homo sapiens_hsa050120.72513552
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71857722
55Antigen processing and presentation_Homo sapiens_hsa046120.70077034
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67042409
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66858720
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65824149
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65022581
60Peroxisome_Homo sapiens_hsa041460.63775134
61HTLV-I infection_Homo sapiens_hsa051660.62585665
62Huntingtons disease_Homo sapiens_hsa050160.58991185
63Sulfur relay system_Homo sapiens_hsa041220.57413092
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55242627
65Oocyte meiosis_Homo sapiens_hsa041140.53156119
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51676174
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50689870
68Colorectal cancer_Homo sapiens_hsa052100.50420290
69Lysine degradation_Homo sapiens_hsa003100.49662160
70Fructose and mannose metabolism_Homo sapiens_hsa000510.48936774
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48286920
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47272208
73Measles_Homo sapiens_hsa051620.45914473
74Fatty acid degradation_Homo sapiens_hsa000710.44795377
75Alcoholism_Homo sapiens_hsa050340.42153903
76Basal cell carcinoma_Homo sapiens_hsa052170.38618627
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36827860
78Pyruvate metabolism_Homo sapiens_hsa006200.36159766
79Shigellosis_Homo sapiens_hsa051310.33169022
80Arginine biosynthesis_Homo sapiens_hsa002200.32282149
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.32170908
82Butanoate metabolism_Homo sapiens_hsa006500.31946238
83Acute myeloid leukemia_Homo sapiens_hsa052210.31052454
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29149380
85Protein export_Homo sapiens_hsa030600.28852521
86Galactose metabolism_Homo sapiens_hsa000520.28527648
87Phenylalanine metabolism_Homo sapiens_hsa003600.28511867
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.27578849
89Metabolic pathways_Homo sapiens_hsa011000.27025226
90Hepatitis B_Homo sapiens_hsa051610.26972224
91Vitamin B6 metabolism_Homo sapiens_hsa007500.24808338
92Glutathione metabolism_Homo sapiens_hsa004800.24604026
93Hippo signaling pathway_Homo sapiens_hsa043900.24547689
94Hedgehog signaling pathway_Homo sapiens_hsa043400.23772591
95Vibrio cholerae infection_Homo sapiens_hsa051100.23008467
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22275828
97Influenza A_Homo sapiens_hsa051640.22158501
98Legionellosis_Homo sapiens_hsa051340.21868053
99Oxidative phosphorylation_Homo sapiens_hsa001900.21698911
100beta-Alanine metabolism_Homo sapiens_hsa004100.21281336
101Apoptosis_Homo sapiens_hsa042100.20466363
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20448018
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20093736
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17664941
105Wnt signaling pathway_Homo sapiens_hsa043100.17404509
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16473469
107Adherens junction_Homo sapiens_hsa045200.14688805
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14469532
109N-Glycan biosynthesis_Homo sapiens_hsa005100.14460017
110TGF-beta signaling pathway_Homo sapiens_hsa043500.13482052
111Non-small cell lung cancer_Homo sapiens_hsa052230.13221245
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.12564316
113HIF-1 signaling pathway_Homo sapiens_hsa040660.12351231
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11638310
115MicroRNAs in cancer_Homo sapiens_hsa052060.11220189
116Hematopoietic cell lineage_Homo sapiens_hsa046400.11094450
117Viral myocarditis_Homo sapiens_hsa054160.10939266
118Tyrosine metabolism_Homo sapiens_hsa003500.10806455
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09502024
120Chronic myeloid leukemia_Homo sapiens_hsa052200.08668980
121Arginine and proline metabolism_Homo sapiens_hsa003300.08570594
122B cell receptor signaling pathway_Homo sapiens_hsa046620.08546004
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.07979317
124Regulation of autophagy_Homo sapiens_hsa041400.07596512
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.07145252
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07134538
127Notch signaling pathway_Homo sapiens_hsa043300.05892130
128Alzheimers disease_Homo sapiens_hsa050100.04638960
129FoxO signaling pathway_Homo sapiens_hsa040680.04551767
130Olfactory transduction_Homo sapiens_hsa047400.03192903
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.02973951
132T cell receptor signaling pathway_Homo sapiens_hsa046600.02380600

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