PASD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.94039987
2nuclear pore organization (GO:0006999)6.04308457
3regulation of translational fidelity (GO:0006450)5.66516530
4mitotic chromosome condensation (GO:0007076)5.56256795
5pore complex assembly (GO:0046931)5.14814039
6DNA unwinding involved in DNA replication (GO:0006268)5.13087147
7gonadal mesoderm development (GO:0007506)5.10507892
8formation of translation preinitiation complex (GO:0001731)4.65489115
9mitotic nuclear envelope disassembly (GO:0007077)4.62507770
10DNA replication initiation (GO:0006270)4.40141442
11DNA replication checkpoint (GO:0000076)4.37423368
12mitotic sister chromatid segregation (GO:0000070)4.35101673
13membrane disassembly (GO:0030397)4.33695412
14nuclear envelope disassembly (GO:0051081)4.33695412
15ribosomal small subunit biogenesis (GO:0042274)4.30167940
16homocysteine metabolic process (GO:0050667)4.27782710
17Golgi transport vesicle coating (GO:0048200)4.27511022
18COPI coating of Golgi vesicle (GO:0048205)4.27511022
19meiotic chromosome segregation (GO:0045132)4.24116399
20DNA strand elongation involved in DNA replication (GO:0006271)4.14288884
21sister chromatid segregation (GO:0000819)4.10119190
22DNA methylation involved in gamete generation (GO:0043046)4.09268063
23DNA strand elongation (GO:0022616)4.05597571
24viral transcription (GO:0019083)4.03001528
25ribosomal large subunit biogenesis (GO:0042273)4.02328667
26regulation of mitotic spindle organization (GO:0060236)3.98275141
27ribosome assembly (GO:0042255)3.97878825
28translational termination (GO:0006415)3.93518920
29regulation of RNA export from nucleus (GO:0046831)3.90737068
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.83322533
31midgut development (GO:0007494)3.82714080
32regulation of histone H3-K27 methylation (GO:0061085)3.81040638
33telomere maintenance via semi-conservative replication (GO:0032201)3.77485020
34ribonucleoprotein complex biogenesis (GO:0022613)3.70769509
35DNA topological change (GO:0006265)3.66817405
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.64654860
37chromosome condensation (GO:0030261)3.61830066
38purine nucleobase biosynthetic process (GO:0009113)3.58099308
39tRNA aminoacylation for protein translation (GO:0006418)3.56374963
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54192449
41regulation of translational elongation (GO:0006448)3.52052038
42translational initiation (GO:0006413)3.51992511
43nucleobase biosynthetic process (GO:0046112)3.51966162
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.48626397
45ribosome biogenesis (GO:0042254)3.47696618
46proline biosynthetic process (GO:0006561)3.46226738
47regulation of histone H3-K4 methylation (GO:0051569)3.44620975
48amino acid activation (GO:0043038)3.42876419
49tRNA aminoacylation (GO:0043039)3.42876419
50folic acid-containing compound biosynthetic process (GO:0009396)3.41601721
51nuclear envelope organization (GO:0006998)3.40841112
52translational elongation (GO:0006414)3.40799024
53cotranslational protein targeting to membrane (GO:0006613)3.39025422
54folic acid metabolic process (GO:0046655)3.38302252
55synapsis (GO:0007129)3.38086339
56protein targeting to ER (GO:0045047)3.36360168
57piRNA metabolic process (GO:0034587)3.36207002
58IMP biosynthetic process (GO:0006188)3.35771098
59regulation of spindle organization (GO:0090224)3.29947953
60resolution of meiotic recombination intermediates (GO:0000712)3.28183181
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.28148338
62protein export from nucleus (GO:0006611)3.25605698
63cellular protein complex disassembly (GO:0043624)3.25199249
64nucleobase-containing small molecule interconversion (GO:0015949)3.24981920
65regulation of nucleobase-containing compound transport (GO:0032239)3.24177738
66telomere maintenance via recombination (GO:0000722)3.23504931
67DNA packaging (GO:0006323)3.22649415
68protein localization to endoplasmic reticulum (GO:0070972)3.20919729
69maturation of SSU-rRNA (GO:0030490)3.18276477
70mitotic recombination (GO:0006312)3.18209372
71protein localization to chromosome, centromeric region (GO:0071459)3.16410838
72chromosome organization involved in meiosis (GO:0070192)3.13822333
73mitotic metaphase plate congression (GO:0007080)3.13645464
74viral life cycle (GO:0019058)3.12137000
75protein complex disassembly (GO:0043241)3.08962815
76protoporphyrinogen IX metabolic process (GO:0046501)3.07899256
77chromosome segregation (GO:0007059)3.07058238
78oxygen transport (GO:0015671)3.03332168
79ribosomal small subunit assembly (GO:0000028)3.02412049
80macromolecular complex disassembly (GO:0032984)3.01340228
81DNA synthesis involved in DNA repair (GO:0000731)2.99689422
82regulation of centrosome cycle (GO:0046605)2.99094347
83protein localization to kinetochore (GO:0034501)2.97767494
84IMP metabolic process (GO:0046040)2.97712062
85male meiosis (GO:0007140)2.96581933
86gas transport (GO:0015669)2.93745564
87regulation of translational termination (GO:0006449)2.92427345
88DNA conformation change (GO:0071103)2.92038300
89oxidative phosphorylation (GO:0006119)2.86878388
90synaptonemal complex assembly (GO:0007130)2.86507764
91tetrahydrofolate metabolic process (GO:0046653)2.84880229
92diterpenoid biosynthetic process (GO:0016102)2.84202534
93positive regulation of DNA-dependent DNA replication (GO:2000105)2.81509329
94DNA duplex unwinding (GO:0032508)2.81231183
95regulation of histone methylation (GO:0031060)2.80343699
96mitotic sister chromatid cohesion (GO:0007064)2.78970756
97regulation of sister chromatid cohesion (GO:0007063)2.78182555
98negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.74628104
99regulation of chromosome segregation (GO:0051983)2.74613774
100kinetochore organization (GO:0051383)2.69104536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.53689299
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.26619684
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.90792939
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53809557
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.46475891
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25324618
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00403017
8ZNF263_19887448_ChIP-Seq_K562_Human2.93957975
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91119209
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70453337
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69807698
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68429185
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53691073
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50570488
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50378114
16XRN2_22483619_ChIP-Seq_HELA_Human2.50062677
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.37716811
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.33407072
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20281328
20DCP1A_22483619_ChIP-Seq_HELA_Human2.18519973
21AR_21909140_ChIP-Seq_LNCAP_Human2.12775473
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11744064
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.06742560
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.05565763
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.04967670
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.04962540
27TTF2_22483619_ChIP-Seq_HELA_Human2.04685928
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.97638711
29NCOR1_26117541_ChIP-Seq_K562_Human1.91836453
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89926252
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88760707
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.86484174
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85308201
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67900878
35KDM5A_27292631_Chip-Seq_BREAST_Human1.65997653
36GABP_19822575_ChIP-Seq_HepG2_Human1.65540073
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64252218
38CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62010666
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60346555
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58834421
41MYC_22102868_ChIP-Seq_BL_Human1.57628242
42KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55632497
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53827362
44ELK1_19687146_ChIP-ChIP_HELA_Human1.53085674
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52298551
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52171523
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51843733
48FOXP3_21729870_ChIP-Seq_TREG_Human1.44251981
49CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43913278
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40991238
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39490839
52TFEB_21752829_ChIP-Seq_HELA_Human1.36626329
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34756989
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34346316
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29984402
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29908676
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27926768
58VDR_23849224_ChIP-Seq_CD4+_Human1.27454941
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26952128
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.23660366
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22853231
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19248244
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17657623
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.16615034
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15653298
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14929360
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13733864
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11523368
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10620201
70CIITA_25753668_ChIP-Seq_RAJI_Human1.09975769
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07382654
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06704634
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05941473
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02365201
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99505882
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97540968
77GATA1_19941826_ChIP-Seq_K562_Human0.95694777
78TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95628419
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94136539
80CHD1_26751641_Chip-Seq_LNCaP_Human0.92733951
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92223520
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91299673
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90543920
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90076357
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89758095
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89244343
87CLOCK_20551151_ChIP-Seq_293T_Human0.87982386
88ATF3_27146783_Chip-Seq_COLON_Human0.86848593
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86336326
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84959150
91GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84026168
92TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82949110
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80068548
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.79507139
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79294299
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.79291912
97SCL_19346495_ChIP-Seq_HPC-7_Human0.79138683
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.79058691
99TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78161171
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.77757263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.07776932
2MP0004957_abnormal_blastocyst_morpholog3.98885986
3MP0003111_abnormal_nucleus_morphology3.74987999
4MP0003693_abnormal_embryo_hatching3.63407561
5MP0008058_abnormal_DNA_repair3.43031567
6MP0008057_abnormal_DNA_replication3.13214732
7MP0003077_abnormal_cell_cycle3.08433122
8MP0004233_abnormal_muscle_weight3.02499273
9MP0005451_abnormal_body_composition2.77466251
10MP0008995_early_reproductive_senescence2.61746594
11MP0008932_abnormal_embryonic_tissue2.51737443
12MP0003786_premature_aging2.50499705
13MP0009697_abnormal_copulation2.49167375
14MP0008007_abnormal_cellular_replicative2.37421526
15MP0004147_increased_porphyrin_level2.30331401
16MP0002877_abnormal_melanocyte_morpholog2.18357613
17MP0001348_abnormal_lacrimal_gland2.15798330
18MP0010307_abnormal_tumor_latency2.15106870
19MP0000350_abnormal_cell_proliferation1.98905834
20MP0001730_embryonic_growth_arrest1.86652012
21MP0000678_abnormal_parathyroid_gland1.84436623
22MP0003656_abnormal_erythrocyte_physiolo1.81465191
23MP0005076_abnormal_cell_differentiation1.80275288
24MP0001697_abnormal_embryo_size1.77886021
25MP0003806_abnormal_nucleotide_metabolis1.72913787
26MP0003705_abnormal_hypodermis_morpholog1.69793394
27MP0001672_abnormal_embryogenesis/_devel1.67580573
28MP0005380_embryogenesis_phenotype1.67580573
29MP0006035_abnormal_mitochondrial_morpho1.65143404
30MP0003718_maternal_effect1.64192076
31MP0002080_prenatal_lethality1.64060296
32MP0003984_embryonic_growth_retardation1.62746453
33MP0002210_abnormal_sex_determination1.58498065
34MP0010234_abnormal_vibrissa_follicle1.58427388
35MP0002088_abnormal_embryonic_growth/wei1.57159728
36MP0001661_extended_life_span1.56413125
37MP0004808_abnormal_hematopoietic_stem1.50531948
38MP0000313_abnormal_cell_death1.49308104
39MP0005083_abnormal_biliary_tract1.48277920
40MP0000003_abnormal_adipose_tissue1.46383095
41MP0002396_abnormal_hematopoietic_system1.45665647
42MP0001929_abnormal_gametogenesis1.40363868
43MP0002086_abnormal_extraembryonic_tissu1.37349798
44MP0000358_abnormal_cell_content/1.36326105
45MP0003959_abnormal_lean_body1.35877329
46MP0003186_abnormal_redox_activity1.34817912
47MP0005408_hypopigmentation1.34534327
48MP0006036_abnormal_mitochondrial_physio1.33641559
49MP0005171_absent_coat_pigmentation1.24475411
50MP0005058_abnormal_lysosome_morphology1.23590134
51MP0009379_abnormal_foot_pigmentation1.22600578
52MP0001145_abnormal_male_reproductive1.14633208
53MP0002084_abnormal_developmental_patter1.09750676
54MP0002269_muscular_atrophy1.06360903
55MP0000372_irregular_coat_pigmentation1.05907882
56MP0001873_stomach_inflammation1.05468984
57MP0009672_abnormal_birth_weight1.05439323
58MP0003698_abnormal_male_reproductive1.04733592
59MP0000653_abnormal_sex_gland1.01886138
60MP0002085_abnormal_embryonic_tissue0.99633377
61MP0002019_abnormal_tumor_incidence0.95113915
62MP0004185_abnormal_adipocyte_glucose0.89489721
63MP0003385_abnormal_body_wall0.88751569
64MP0000647_abnormal_sebaceous_gland0.87949992
65MP0003699_abnormal_female_reproductive0.87521380
66MP0005501_abnormal_skin_physiology0.87087068
67MP0002161_abnormal_fertility/fecundity0.86313116
68MP0004197_abnormal_fetal_growth/weight/0.85953557
69MP0000377_abnormal_hair_follicle0.84052645
70MP0002009_preneoplasia0.82908218
71MP0005621_abnormal_cell_physiology0.81813802
72MP0005384_cellular_phenotype0.81290691
73MP0001545_abnormal_hematopoietic_system0.80903848
74MP0005397_hematopoietic_system_phenotyp0.80903848
75MP0001881_abnormal_mammary_gland0.80883248
76MP0009703_decreased_birth_body0.79608236
77MP0003950_abnormal_plasma_membrane0.79034864
78MP0002970_abnormal_white_adipose0.78773102
79MP0003221_abnormal_cardiomyocyte_apopto0.78572056
80MP0008877_abnormal_DNA_methylation0.77645089
81MP0002938_white_spotting0.77436271
82MP0005410_abnormal_fertilization0.76699857
83MP0008260_abnormal_autophagy0.75446447
84MP0003136_yellow_coat_color0.73535604
85MP0010630_abnormal_cardiac_muscle0.72287690
86MP0000747_muscle_weakness0.72286155
87MP0002160_abnormal_reproductive_system0.70884972
88MP0000681_abnormal_thyroid_gland0.69619180
89MP0000490_abnormal_crypts_of0.67604370
90MP0005375_adipose_tissue_phenotype0.66963034
91MP0003453_abnormal_keratinocyte_physiol0.65150824
92MP0005409_darkened_coat_color0.63418386
93MP0001243_abnormal_dermal_layer0.63156048
94MP0010352_gastrointestinal_tract_polyps0.62940567
95MP0001186_pigmentation_phenotype0.62370481
96MP0000703_abnormal_thymus_morphology0.60940192
97MP0009931_abnormal_skin_appearance0.60620447
98MP0003942_abnormal_urinary_system0.60118265
99MP0004858_abnormal_nervous_system0.59621779
100MP0008770_decreased_survivor_rate0.58616044

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)4.60007235
2Abnormal gallbladder physiology (HP:0012438)4.60007235
3Truncus arteriosus (HP:0001660)4.59752174
4Ankyloglossia (HP:0010296)4.34470916
5Reticulocytosis (HP:0001923)4.34165826
6Abnormality of reticulocytes (HP:0004312)4.16830029
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.07630465
8Chromsome breakage (HP:0040012)4.05025868
9Hyperthyroidism (HP:0000836)3.85674853
10Pallor (HP:0000980)3.84388186
11Reticulocytopenia (HP:0001896)3.80232237
12Birth length less than 3rd percentile (HP:0003561)3.68412530
13Abnormality of cells of the erythroid lineage (HP:0012130)3.50200026
14Polycythemia (HP:0001901)3.33987712
15Abnormality of oral frenula (HP:0000190)3.25488802
16Abnormality of glycolysis (HP:0004366)3.19023623
17Abnormal hemoglobin (HP:0011902)3.14763771
18Bowel incontinence (HP:0002607)3.12767955
19Macrocytic anemia (HP:0001972)3.03899440
20Abnormality of homocysteine metabolism (HP:0010919)2.98104251
21Homocystinuria (HP:0002156)2.98104251
22Abnormal large intestine physiology (HP:0012700)2.97680332
23Overlapping toe (HP:0001845)2.96431522
24Abnormality of the tricuspid valve (HP:0001702)2.96050991
25Ileus (HP:0002595)2.87313590
26Increased serum pyruvate (HP:0003542)2.77226222
27Hypoparathyroidism (HP:0000829)2.76624779
28Upper limb muscle weakness (HP:0003484)2.68502046
29Progressive muscle weakness (HP:0003323)2.55575618
30Abnormal number of erythroid precursors (HP:0012131)2.53613185
31Breast hypoplasia (HP:0003187)2.53581336
32Increased nuchal translucency (HP:0010880)2.52836998
33Seborrheic dermatitis (HP:0001051)2.45808997
34Cortical dysplasia (HP:0002539)2.45503359
35Abnormality of cochlea (HP:0000375)2.44349098
36Cholelithiasis (HP:0001081)2.43091523
37Relative macrocephaly (HP:0004482)2.39196805
38Abnormality of the heme biosynthetic pathway (HP:0010472)2.39095113
39Dysmetric saccades (HP:0000641)2.38613625
40Microvesicular hepatic steatosis (HP:0001414)2.38140377
41Hypertensive crisis (HP:0100735)2.37973332
42Abnormality of DNA repair (HP:0003254)2.31989677
43Abnormality of pyrimidine metabolism (HP:0004353)2.28419697
44Abnormality of the preputium (HP:0100587)2.21045282
45Submucous cleft hard palate (HP:0000176)2.19881780
46Acute myeloid leukemia (HP:0004808)2.19008092
47Insomnia (HP:0100785)2.16943624
48Myelodysplasia (HP:0002863)2.13937640
49Deep philtrum (HP:0002002)2.13930543
50Increased connective tissue (HP:0009025)2.12902463
51Premature ovarian failure (HP:0008209)2.10985896
52Ragged-red muscle fibers (HP:0003200)2.10781918
53Sandal gap (HP:0001852)2.08839453
54Atelectasis (HP:0100750)2.08434417
55Decreased subcutaneous fat (HP:0001002)2.07983037
56Entropion (HP:0000621)2.04820003
57Abnormal gallbladder morphology (HP:0012437)2.03899346
58Duplicated collecting system (HP:0000081)2.01979401
59Attention deficit hyperactivity disorder (HP:0007018)2.01562689
60Hyperacusis (HP:0010780)1.97533875
61Patellar dislocation (HP:0002999)1.94257925
62Abnormally folded helix (HP:0008544)1.93789788
63Breech presentation (HP:0001623)1.90002550
64Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89741088
65Orthostatic hypotension (HP:0001278)1.89528046
66Abnormality of sulfur amino acid metabolism (HP:0004339)1.89501915
67Esophageal neoplasm (HP:0100751)1.88811072
68Neoplasm of head and neck (HP:0012288)1.88811072
69Abnormality of the gallbladder (HP:0005264)1.87940547
70Aplasia/Hypoplasia of the uvula (HP:0010293)1.87775117
71Aplasia/Hypoplasia of the earlobes (HP:0009906)1.86313346
72Morphological abnormality of the inner ear (HP:0011390)1.84437309
73Flat cornea (HP:0007720)1.83724720
74Poikiloderma (HP:0001029)1.81315177
75Abnormality of subcutaneous fat tissue (HP:0001001)1.81008425
76Abnormality of chromosome stability (HP:0003220)1.80114179
77Small intestinal stenosis (HP:0012848)1.79748819
78Duodenal stenosis (HP:0100867)1.79748819
79Squamous cell carcinoma (HP:0002860)1.79260483
80Ureteral duplication (HP:0000073)1.78157091
81Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77503980
82Cerebral edema (HP:0002181)1.76695150
83Abnormality of the renal collecting system (HP:0004742)1.76373638
84Cheekbone underdevelopment (HP:0010669)1.76368946
85Heterotopia (HP:0002282)1.76017852
86Obsessive-compulsive behavior (HP:0000722)1.75482180
87Hyperbilirubinemia (HP:0002904)1.73259687
88Poikilocytosis (HP:0004447)1.73209488
89Cerebellar dysplasia (HP:0007033)1.71630843
90Cafe-au-lait spot (HP:0000957)1.70160863
91Short middle phalanx of the 5th finger (HP:0004220)1.69341544
92Abnormality of the calcaneus (HP:0008364)1.69322178
93Sparse lateral eyebrow (HP:0005338)1.69100377
94Calcaneovalgus deformity (HP:0001848)1.68962693
95Secondary amenorrhea (HP:0000869)1.68638405
96Hyperammonemia (HP:0001987)1.67857084
97Cortical visual impairment (HP:0100704)1.66645672
98Distal upper limb amyotrophy (HP:0007149)1.65806726
99Upper limb amyotrophy (HP:0009129)1.65806726
100Disproportionate tall stature (HP:0001519)1.65775650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.87424280
2PBK3.87136318
3PDK23.16061062
4TTK3.01088954
5EEF2K2.75008543
6NEK12.74131292
7IRAK32.71979534
8ICK2.61261418
9WEE12.60931310
10NME22.59086642
11KSR22.52076663
12CDK122.51330696
13CDC72.27013247
14BUB12.01657727
15RAF11.92721378
16SCYL21.86745290
17MST1R1.78447433
18BRAF1.75779993
19RPS6KB21.74190676
20MAP3K21.71561741
21BRSK21.70142786
22TRIB31.68606105
23CLK11.67643328
24BMPR21.64559928
25AKT31.57659918
26NEK21.55928080
27SRPK11.55765798
28CHEK21.52978368
29RIPK41.49995668
30PLK41.47608922
31TSSK61.44950457
32MAP3K81.44775404
33BRSK11.31456273
34PAK41.24818541
35MET1.23877545
36KSR11.22290185
37NME11.20371881
38LATS21.18856175
39EIF2AK31.18297510
40CHEK11.17107110
41BMX1.11865726
42CCNB11.06964726
43MST41.05058427
44AURKB1.03023678
45ERBB41.02626654
46SMG11.01939564
47CDK71.01362559
48ATR0.96895804
49STK40.96766332
50MTOR0.95956843
51CDK80.88590158
52PLK10.87655645
53NTRK30.87125692
54CDK40.85991798
55BRD40.82343704
56PNCK0.80692665
57CDK10.79223381
58AURKA0.77617613
59MARK30.77313020
60ERN10.75757217
61CDK20.74601699
62STK30.73688612
63NEK60.70635545
64ATM0.67075883
65PLK30.63714842
66AKT20.63501453
67LATS10.62421828
68ALK0.61074954
69TTN0.60961126
70YES10.58136983
71PAK10.56961341
72PRPF4B0.56929384
73CSNK2A20.55695856
74LRRK20.54337333
75PTK60.54309363
76PKN20.53775767
77CSNK1E0.53571831
78PRKG20.52366615
79TAOK20.51566368
80PASK0.49157645
81NTRK10.48976840
82ILK0.48297096
83MAPK110.47800990
84STK100.47049732
85MAP3K90.46754309
86MAP2K10.44138292
87CDK30.43579553
88PIM10.43352401
89SIK10.42032061
90ARAF0.38739194
91MAPK100.38685691
92RPS6KA40.37944212
93IRAK20.37053599
94MAP3K100.36160369
95MAPKAPK50.34392047
96MAP3K10.34378497
97RET0.34152979
98PTK20.33976497
99MAPK140.33802387
100CSNK2A10.33632822

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.08184761
2DNA replication_Homo sapiens_hsa030304.00383443
3Mismatch repair_Homo sapiens_hsa034303.56140739
4Ribosome_Homo sapiens_hsa030103.33808217
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83980612
6One carbon pool by folate_Homo sapiens_hsa006702.74685096
7RNA transport_Homo sapiens_hsa030132.56253653
8Nucleotide excision repair_Homo sapiens_hsa034202.56190980
9Cell cycle_Homo sapiens_hsa041102.44026382
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34796183
11Homologous recombination_Homo sapiens_hsa034402.32029618
12Spliceosome_Homo sapiens_hsa030402.19397385
13Biosynthesis of amino acids_Homo sapiens_hsa012302.05451327
14Folate biosynthesis_Homo sapiens_hsa007901.93014068
15Fanconi anemia pathway_Homo sapiens_hsa034601.81338731
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73990954
17mRNA surveillance pathway_Homo sapiens_hsa030151.71770611
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.67520240
19Carbon metabolism_Homo sapiens_hsa012001.62884376
20Base excision repair_Homo sapiens_hsa034101.62360216
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61067977
22Arginine biosynthesis_Homo sapiens_hsa002201.59037003
23Thyroid cancer_Homo sapiens_hsa052161.58720417
24Pyruvate metabolism_Homo sapiens_hsa006201.56768743
25Pentose phosphate pathway_Homo sapiens_hsa000301.50121446
26Basal transcription factors_Homo sapiens_hsa030221.45965979
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33248095
28N-Glycan biosynthesis_Homo sapiens_hsa005101.32311930
29Fructose and mannose metabolism_Homo sapiens_hsa000511.26136130
30Non-homologous end-joining_Homo sapiens_hsa034501.25743752
31Proteasome_Homo sapiens_hsa030501.25383682
32RNA polymerase_Homo sapiens_hsa030201.24662185
33Pyrimidine metabolism_Homo sapiens_hsa002401.24571367
34Chronic myeloid leukemia_Homo sapiens_hsa052201.21643095
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.12772331
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10718879
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.09693196
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07635252
39Acute myeloid leukemia_Homo sapiens_hsa052211.02745520
40Oocyte meiosis_Homo sapiens_hsa041140.99147485
41Non-small cell lung cancer_Homo sapiens_hsa052230.95078497
42RNA degradation_Homo sapiens_hsa030180.94801252
43Vitamin B6 metabolism_Homo sapiens_hsa007500.91403208
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89058666
45Selenocompound metabolism_Homo sapiens_hsa004500.88226526
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88079690
47Purine metabolism_Homo sapiens_hsa002300.87800296
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86862286
49Viral carcinogenesis_Homo sapiens_hsa052030.84836104
50Bladder cancer_Homo sapiens_hsa052190.80282059
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77797782
52Pancreatic cancer_Homo sapiens_hsa052120.77300190
53Huntingtons disease_Homo sapiens_hsa050160.76916188
54Renal cell carcinoma_Homo sapiens_hsa052110.76505474
55Small cell lung cancer_Homo sapiens_hsa052220.74834433
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.73391408
57Galactose metabolism_Homo sapiens_hsa000520.72969285
58mTOR signaling pathway_Homo sapiens_hsa041500.70919830
59Parkinsons disease_Homo sapiens_hsa050120.67888932
60Protein export_Homo sapiens_hsa030600.64864407
61Endometrial cancer_Homo sapiens_hsa052130.62255934
62Oxidative phosphorylation_Homo sapiens_hsa001900.60676675
63ErbB signaling pathway_Homo sapiens_hsa040120.60516474
64HIF-1 signaling pathway_Homo sapiens_hsa040660.58390110
65Sulfur relay system_Homo sapiens_hsa041220.57051505
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56355824
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53911669
68Glioma_Homo sapiens_hsa052140.51308925
69Epstein-Barr virus infection_Homo sapiens_hsa051690.49930616
70Lysine degradation_Homo sapiens_hsa003100.49844603
71Insulin signaling pathway_Homo sapiens_hsa049100.49240596
72MicroRNAs in cancer_Homo sapiens_hsa052060.47564277
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45942761
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45345581
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44025882
76VEGF signaling pathway_Homo sapiens_hsa043700.42947029
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40285455
78Alzheimers disease_Homo sapiens_hsa050100.39635790
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39082678
80Prion diseases_Homo sapiens_hsa050200.38883546
81Other glycan degradation_Homo sapiens_hsa005110.37691306
82Steroid biosynthesis_Homo sapiens_hsa001000.37172090
83Colorectal cancer_Homo sapiens_hsa052100.36936565
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34795376
85Metabolic pathways_Homo sapiens_hsa011000.33955935
86Prostate cancer_Homo sapiens_hsa052150.31856726
87Glutathione metabolism_Homo sapiens_hsa004800.29990406
88Propanoate metabolism_Homo sapiens_hsa006400.29919671
89Melanoma_Homo sapiens_hsa052180.28730907
90AMPK signaling pathway_Homo sapiens_hsa041520.27266295
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.27252201
92Fatty acid elongation_Homo sapiens_hsa000620.27121904
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.26608371
94HTLV-I infection_Homo sapiens_hsa051660.25558736
95Olfactory transduction_Homo sapiens_hsa047400.25531068
96Adherens junction_Homo sapiens_hsa045200.24566486
97p53 signaling pathway_Homo sapiens_hsa041150.24368848
98Hepatitis B_Homo sapiens_hsa051610.23877009
99Phenylalanine metabolism_Homo sapiens_hsa003600.23795968
100Prolactin signaling pathway_Homo sapiens_hsa049170.22750596

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »