PATE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of clathrin-mediated endocytosis (GO:2000369)9.85276171
2regulation of acrosome reaction (GO:0060046)8.24570923
3regulation of antigen processing and presentation (GO:0002577)8.16149239
4fusion of sperm to egg plasma membrane (GO:0007342)7.64507115
5regulation of hydrogen peroxide metabolic process (GO:0010310)6.48269502
6response to misfolded protein (GO:0051788)6.10335098
7negative regulation of receptor-mediated endocytosis (GO:0048261)5.97267027
8plasma membrane fusion (GO:0045026)5.84011003
9regulation of Cdc42 GTPase activity (GO:0043088)5.73983346
10GPI anchor biosynthetic process (GO:0006506)5.28580838
11GPI anchor metabolic process (GO:0006505)4.70862024
12complement activation, alternative pathway (GO:0006957)4.68440251
13macroautophagy (GO:0016236)4.57558403
14misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.47117481
15behavioral response to nicotine (GO:0035095)4.30792380
16negative regulation of metanephros development (GO:0072217)4.25161092
17sulfur amino acid catabolic process (GO:0000098)4.13325645
18valine metabolic process (GO:0006573)4.02476959
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.97575245
20cellular ketone body metabolic process (GO:0046950)3.92462152
21detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.89702550
22respiratory burst (GO:0045730)3.89384788
23negative regulation of cytosolic calcium ion concentration (GO:0051481)3.87162320
24detection of light stimulus involved in visual perception (GO:0050908)3.84335501
25detection of light stimulus involved in sensory perception (GO:0050962)3.84335501
26fucose catabolic process (GO:0019317)3.75129146
27L-fucose metabolic process (GO:0042354)3.75129146
28L-fucose catabolic process (GO:0042355)3.75129146
29negative regulation of endopeptidase activity (GO:0010951)3.72207041
30regulation of cilium movement (GO:0003352)3.72076803
31brown fat cell differentiation (GO:0050873)3.69111018
32piRNA metabolic process (GO:0034587)3.68439741
33tryptophan catabolic process (GO:0006569)3.68161178
34indole-containing compound catabolic process (GO:0042436)3.68161178
35indolalkylamine catabolic process (GO:0046218)3.68161178
36indolalkylamine metabolic process (GO:0006586)3.67989206
37photoreceptor cell maintenance (GO:0045494)3.58944794
38negative regulation of peptidase activity (GO:0010466)3.58735986
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.54634102
40axoneme assembly (GO:0035082)3.54552745
41ketone body metabolic process (GO:1902224)3.54388914
42kynurenine metabolic process (GO:0070189)3.49110995
43signal peptide processing (GO:0006465)3.46832322
44positive regulation of response to oxidative stress (GO:1902884)3.45401500
45positive regulation of cellular response to oxidative stress (GO:1900409)3.45401500
46response to pheromone (GO:0019236)3.45111036
47cilium or flagellum-dependent cell motility (GO:0001539)3.42813072
48DNA deamination (GO:0045006)3.42646582
49regulation of hexokinase activity (GO:1903299)3.40637636
50regulation of glucokinase activity (GO:0033131)3.40637636
51regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.38138187
52retinal cone cell development (GO:0046549)3.31252843
53epithelial cilium movement (GO:0003351)3.30377713
54proline transport (GO:0015824)3.28979068
55behavioral response to ethanol (GO:0048149)3.21410314
56cytolysis (GO:0019835)3.20679442
57regulation of respiratory burst (GO:0060263)3.19262480
58mannose metabolic process (GO:0006013)3.12988757
59positive regulation of digestive system process (GO:0060456)3.12204594
60regulation of calcium ion-dependent exocytosis (GO:0017158)3.08846893
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07548185
62protein complex biogenesis (GO:0070271)3.05380422
63response to lipoprotein particle (GO:0055094)3.02916722
64folic acid-containing compound biosynthetic process (GO:0009396)3.02878464
65positive regulation of fatty acid transport (GO:2000193)3.02387559
66negative regulation of endocytosis (GO:0045806)3.01737184
67auditory receptor cell stereocilium organization (GO:0060088)2.99853831
68pyrimidine ribonucleoside catabolic process (GO:0046133)2.93174597
69cilium movement (GO:0003341)2.91632825
70positive regulation of prostaglandin secretion (GO:0032308)2.89948376
71DNA methylation involved in gamete generation (GO:0043046)2.88482012
72water-soluble vitamin biosynthetic process (GO:0042364)2.88178861
73tryptophan metabolic process (GO:0006568)2.87067456
74glycolipid biosynthetic process (GO:0009247)2.86540293
75regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.85868775
76negative regulation of reactive oxygen species metabolic process (GO:2000378)2.84708004
77positive regulation of respiratory burst (GO:0060267)2.83469289
78mitotic metaphase plate congression (GO:0007080)2.83214734
79arginine catabolic process (GO:0006527)2.81715628
80reflex (GO:0060004)2.80807838
81white fat cell differentiation (GO:0050872)2.79952146
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79588808
83phosphatidylinositol acyl-chain remodeling (GO:0036149)2.77616834
84positive regulation of glomerulus development (GO:0090193)2.77570067
85regulation of histone H3-K27 methylation (GO:0061085)2.75502531
86triglyceride catabolic process (GO:0019433)2.73772633
87cytochrome complex assembly (GO:0017004)2.73535838
88alanine transport (GO:0032328)2.72011109
89protein K11-linked deubiquitination (GO:0035871)2.71491269
90negative regulation of proteolysis (GO:0045861)2.70697114
91regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.70646982
92regulation of female gonad development (GO:2000194)2.70434405
93superoxide anion generation (GO:0042554)2.68061365
94positive regulation of receptor biosynthetic process (GO:0010870)2.67615058
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67546550
96mitochondrial respiratory chain complex I assembly (GO:0032981)2.67546550
97NADH dehydrogenase complex assembly (GO:0010257)2.67546550
98indole-containing compound metabolic process (GO:0042430)2.66040764
99inner ear receptor stereocilium organization (GO:0060122)2.65113720
100mitochondrial respiratory chain complex assembly (GO:0033108)2.65106534
101low-density lipoprotein particle clearance (GO:0034383)2.65054348
102inositol phosphate catabolic process (GO:0071545)2.64740466
103negative regulation of protein autophosphorylation (GO:0031953)2.64269826
104respiratory chain complex IV assembly (GO:0008535)2.64244819
105cell differentiation involved in metanephros development (GO:0072202)2.64003856
106regulation of glycogen (starch) synthase activity (GO:2000465)2.63891940
107regulation of microtubule-based movement (GO:0060632)2.62910171
108production of molecular mediator involved in inflammatory response (GO:0002532)2.62783451
109dopamine transport (GO:0015872)2.62676618
110cilium organization (GO:0044782)2.62201749
111cellular response to heat (GO:0034605)2.61850816
112oxaloacetate metabolic process (GO:0006107)2.61565777
113glycerophospholipid catabolic process (GO:0046475)2.61257196
114male meiosis (GO:0007140)2.60560771
115nephron tubule morphogenesis (GO:0072078)2.59552137
116nephron epithelium morphogenesis (GO:0072088)2.59552137
117cilium morphogenesis (GO:0060271)2.59438393
118coenzyme catabolic process (GO:0009109)2.59419426
119nonmotile primary cilium assembly (GO:0035058)2.58456456
120regulation of bile acid biosynthetic process (GO:0070857)2.58116223
121negative regulation of epidermal cell differentiation (GO:0045605)2.57972452
122negative regulation of protein processing (GO:0010955)2.57889372
123negative regulation of protein maturation (GO:1903318)2.57889372
124negative regulation of cAMP-mediated signaling (GO:0043951)2.57450562
125L-methionine salvage (GO:0071267)2.57351245
126L-methionine biosynthetic process (GO:0071265)2.57351245
127amino acid salvage (GO:0043102)2.57351245
128glycerolipid catabolic process (GO:0046503)2.56469702
129negative regulation of transcription by competitive promoter binding (GO:0010944)2.56411252
130positive regulation of cholesterol transport (GO:0032376)2.55459707
131positive regulation of sterol transport (GO:0032373)2.55459707
132binding of sperm to zona pellucida (GO:0007339)2.55336498
133cellular biogenic amine catabolic process (GO:0042402)2.55151206
134amine catabolic process (GO:0009310)2.55151206
135adenosine metabolic process (GO:0046085)2.52805175
136C4-dicarboxylate transport (GO:0015740)2.52562188
137transmission of nerve impulse (GO:0019226)2.52494913
138cilium assembly (GO:0042384)2.52253471
139photoreceptor cell development (GO:0042461)2.51719670
140cAMP catabolic process (GO:0006198)2.51338280
141positive regulation of icosanoid secretion (GO:0032305)2.50371652
142multicellular organism reproduction (GO:0032504)2.49411607
143regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49333323
144regulation of hydrogen peroxide-induced cell death (GO:1903205)2.49041806
145positive regulation of cAMP-mediated signaling (GO:0043950)2.48632087
146cyclic nucleotide catabolic process (GO:0009214)2.46142627
147visual perception (GO:0007601)2.45246811
148intra-S DNA damage checkpoint (GO:0031573)2.44886033
149L-serine metabolic process (GO:0006563)2.44818932
150double-strand break repair via homologous recombination (GO:0000724)2.44108677
151rhodopsin mediated signaling pathway (GO:0016056)2.44105066
152adaptation of signaling pathway (GO:0023058)2.43949449
153recombinational repair (GO:0000725)2.43481714
154sensory perception of light stimulus (GO:0050953)2.43394359
155benzene-containing compound metabolic process (GO:0042537)2.43391612
156meiotic chromosome segregation (GO:0045132)2.43028097
157homocysteine metabolic process (GO:0050667)2.41532745
158regulation of receptor biosynthetic process (GO:0010869)2.41381460
159establishment of protein localization to Golgi (GO:0072600)2.41334129
160citrulline biosynthetic process (GO:0019240)2.40006494
161RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39451453
162mesenchymal cell differentiation involved in renal system development (GO:2001012)2.39273219
163mesenchymal cell differentiation involved in kidney development (GO:0072161)2.39273219
164neural tube formation (GO:0001841)2.39265483
165metanephric tubule development (GO:0072170)2.38909123
166metanephric nephron tubule development (GO:0072234)2.38909123
167phosphorylated carbohydrate dephosphorylation (GO:0046838)2.37813913
168inositol phosphate dephosphorylation (GO:0046855)2.37813913
169negative regulation of phagocytosis (GO:0050765)2.37808996
170negative regulation of telomere maintenance (GO:0032205)2.37807928
171RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37334872
172tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37334872
173poly(A)+ mRNA export from nucleus (GO:0016973)2.36402157
174nucleoside diphosphate catabolic process (GO:0009134)2.36176326
175regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.35550131
176kinetochore assembly (GO:0051382)2.34099243
177positive regulation of receptor recycling (GO:0001921)2.33619810
178neutral lipid catabolic process (GO:0046461)2.32943319
179acylglycerol catabolic process (GO:0046464)2.32943319
180mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.32451496
181platelet dense granule organization (GO:0060155)2.31293619
182negative regulation of oxidoreductase activity (GO:0051354)2.30525667
183meiotic cell cycle (GO:0051321)2.29789492
184epithelial cell differentiation involved in kidney development (GO:0035850)2.29421293
185metanephric nephron epithelium development (GO:0072243)2.28025430
186toxin transport (GO:1901998)2.26857515
187cellular anion homeostasis (GO:0030002)2.25997961
188positive regulation of smooth muscle cell migration (GO:0014911)2.25904762
189regulation of endopeptidase activity (GO:0052548)2.23686833
190antigen processing and presentation of endogenous peptide antigen (GO:0002483)19.5418950
191antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)19.5418950
192regulation of antigen processing and presentation of peptide antigen (GO:0002583)18.3430568
193antigen processing and presentation via MHC class Ib (GO:0002475)17.5962497
194antigen processing and presentation of endogenous antigen (GO:0019883)16.5455157
195positive regulation of antigen processing and presentation (GO:0002579)10.0808606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human5.80624707
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.83069676
3VDR_22108803_ChIP-Seq_LS180_Human3.41523456
4KAP1_22055183_ChIP-Seq_ESCs_Mouse3.40705723
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.95641810
6GBX2_23144817_ChIP-Seq_PC3_Human2.91344095
7EZH2_22144423_ChIP-Seq_EOC_Human2.70262164
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50071821
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46337495
10AR_21572438_ChIP-Seq_LNCaP_Human2.21181479
11* STAT1_17558387_ChIP-Seq_HELA_Human2.15402473
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09736556
13P300_19829295_ChIP-Seq_ESCs_Human2.07705522
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.06463312
15TAF15_26573619_Chip-Seq_HEK293_Human2.05753988
16RNF2_27304074_Chip-Seq_NSC_Mouse2.04665422
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.02385033
18GATA1_22025678_ChIP-Seq_K562_Human11.8964470
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93120784
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92878906
21ER_23166858_ChIP-Seq_MCF-7_Human1.92842811
22BCAT_22108803_ChIP-Seq_LS180_Human1.89891951
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87991801
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84336816
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81716215
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76406533
27CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72710832
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72339589
29STAT3_23295773_ChIP-Seq_U87_Human1.66945080
30HTT_18923047_ChIP-ChIP_STHdh_Human1.64735872
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62020037
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.61220068
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.60066663
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59327574
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.58204593
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.58204593
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58117570
38TCF4_23295773_ChIP-Seq_U87_Human1.57785759
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57405586
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56140039
41CBP_20019798_ChIP-Seq_JUKART_Human1.56120701
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56120701
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54161309
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53765283
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51424451
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51351801
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51351801
48KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.51274120
49TP53_22573176_ChIP-Seq_HFKS_Human1.51062117
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50823817
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50473988
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50420115
53MYC_19915707_ChIP-ChIP_AK7_Human1.50411594
54SOX2_19829295_ChIP-Seq_ESCs_Human1.48736160
55NANOG_19829295_ChIP-Seq_ESCs_Human1.48736160
56AR_25329375_ChIP-Seq_VCAP_Human1.48540670
57VDR_24787735_ChIP-Seq_THP-1_Human1.46582251
58TCF4_22108803_ChIP-Seq_LS180_Human1.46530610
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46346542
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.44753407
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42704484
62KLF4_18555785_Chip-Seq_ESCs_Mouse1.41289054
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.38486937
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37971080
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36071962
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34314018
67IRF1_19129219_ChIP-ChIP_H3396_Human1.33424966
68CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.31579458
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31207021
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30866823
71EWS_26573619_Chip-Seq_HEK293_Human1.30866052
72ZNF274_21170338_ChIP-Seq_K562_Hela1.28438171
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28027404
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.26312813
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.25273123
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24216884
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.22695467
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22001360
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.21283210
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.20728803
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20552798
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.19767734
83WDR5_24793694_ChIP-Seq_LNCAP_Human1.17978086
84REST_21632747_ChIP-Seq_MESCs_Mouse1.17477862
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17124638
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.16157923
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15477920
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.15383019
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14041230
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13656150
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12903781
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12762442
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12329331
94GATA3_21867929_ChIP-Seq_CD8_Mouse1.11050029
95KDM2B_26808549_Chip-Seq_REH_Human1.10322985
96CEBPB_22108803_ChIP-Seq_LS180_Human1.09933959
97SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09847955
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.09811579
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09613573
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09604229
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09297466
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.08940132
103MYC_18940864_ChIP-ChIP_HL60_Human1.08763356
104CBP_21632823_ChIP-Seq_H3396_Human1.08137332
105SMAD4_21799915_ChIP-Seq_A2780_Human1.06962813
106E2F7_22180533_ChIP-Seq_HELA_Human1.06747730
107TAF2_19829295_ChIP-Seq_ESCs_Human1.06213883
108POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06101220
109P53_22387025_ChIP-Seq_ESCs_Mouse1.05990371
110SMRT_27268052_Chip-Seq_Bcells_Human1.05784292
111ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05477837
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04981030
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04802348
114NCOR_22424771_ChIP-Seq_293T_Human1.04236664
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04138588
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03726353
117SOX2_18555785_Chip-Seq_ESCs_Mouse1.03348574
118FLI1_21867929_ChIP-Seq_CD8_Mouse1.02912798
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02876366
120SOX2_20726797_ChIP-Seq_SW620_Human1.02578645
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.02499046
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02372797
123ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01724915
124HOXB7_26014856_ChIP-Seq_BT474_Human1.01692712
125GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01311020
126OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00617231
127CSB_26484114_Chip-Seq_FIBROBLAST_Human1.00240362
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99893949
129AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98682820
130P53_21459846_ChIP-Seq_SAOS-2_Human0.98668601
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98562507
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97719474
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.97718613
134FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97491196
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.95323411
136JUN_21703547_ChIP-Seq_K562_Human0.95123622
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94381542
138NFE2_27457419_Chip-Seq_LIVER_Mouse0.93189273
139ZFX_18555785_Chip-Seq_ESCs_Mouse0.92810708
140EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92109778
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.92020367
142EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91119457
143GATA3_21867929_ChIP-Seq_TH1_Mouse0.90249779
144AR_20517297_ChIP-Seq_VCAP_Human0.90105165
145AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89984221
146SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89453539
147SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88250611
148CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88250472
149* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87626938
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87324552
151P300_18555785_Chip-Seq_ESCs_Mouse0.87062176
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86095951
153OCT4_18555785_Chip-Seq_ESCs_Mouse0.85933355
154RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85349395
155OCT1_27270436_Chip-Seq_PROSTATE_Human0.85349263
156AR_21909140_ChIP-Seq_LNCAP_Human0.84443446
157PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84138600
158CTCF_18555785_Chip-Seq_ESCs_Mouse0.83631004
159FUS_26573619_Chip-Seq_HEK293_Human0.82447958
160RUNX2_22187159_ChIP-Seq_PCA_Human0.82205798
161CDX2_22108803_ChIP-Seq_LS180_Human0.80769232
162* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80039049
163SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.79933601
164CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78805285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.38144478
2MP0010386_abnormal_urinary_bladder4.98377324
3MP0002102_abnormal_ear_morphology4.85204496
4MP0005670_abnormal_white_adipose4.84656833
5MP0002876_abnormal_thyroid_physiology4.37990176
6MP0009840_abnormal_foam_cell3.52613193
7MP0001853_heart_inflammation2.85222928
8MP0005551_abnormal_eye_electrophysiolog2.76830216
9MP0002638_abnormal_pupillary_reflex2.56499746
10MP0005645_abnormal_hypothalamus_physiol2.53314961
11MP0003656_abnormal_erythrocyte_physiolo2.52538591
12MP0002735_abnormal_chemical_nociception2.43211606
13MP0003880_abnormal_central_pattern2.30819139
14MP0002837_dystrophic_cardiac_calcinosis2.27270020
15MP0003646_muscle_fatigue2.21408660
16MP0008995_early_reproductive_senescence2.20149992
17MP0003183_abnormal_peptide_metabolism2.19249077
18MP0000685_abnormal_immune_system2.12756074
19MP0000462_abnormal_digestive_system2.11940498
20MP0005666_abnormal_adipose_tissue2.07620656
21MP0002736_abnormal_nociception_after2.03974670
22MP0001501_abnormal_sleep_pattern1.98306940
23MP0006276_abnormal_autonomic_nervous1.96492765
24MP0006072_abnormal_retinal_apoptosis1.94750279
25MP0005379_endocrine/exocrine_gland_phen1.94268401
26MP0008004_abnormal_stomach_pH1.87505102
27MP0001764_abnormal_homeostasis1.84640817
28MP0000427_abnormal_hair_cycle1.83113919
29MP0009745_abnormal_behavioral_response1.82847420
30MP0005310_abnormal_salivary_gland1.77274249
31MP0005253_abnormal_eye_physiology1.73115217
32MP0003136_yellow_coat_color1.72796445
33MP0009046_muscle_twitch1.71710770
34MP0009379_abnormal_foot_pigmentation1.68639393
35MP0003186_abnormal_redox_activity1.67968721
36MP0005375_adipose_tissue_phenotype1.66687558
37MP0001984_abnormal_olfaction1.63912178
38MP0000681_abnormal_thyroid_gland1.61532485
39MP0001485_abnormal_pinna_reflex1.54886057
40MP0003787_abnormal_imprinting1.54233649
41MP0005084_abnormal_gallbladder_morpholo1.53056823
42MP0002272_abnormal_nervous_system1.52536783
43MP0003172_abnormal_lysosome_physiology1.51054250
44MP0001486_abnormal_startle_reflex1.50680360
45MP0000003_abnormal_adipose_tissue1.49443424
46MP0005085_abnormal_gallbladder_physiolo1.48971755
47MP0002254_reproductive_system_inflammat1.47637912
48MP0000372_irregular_coat_pigmentation1.46714662
49MP0004145_abnormal_muscle_electrophysio1.46497531
50MP0003195_calcinosis1.43182842
51MP0005174_abnormal_tail_pigmentation1.41357333
52MP0002938_white_spotting1.37215137
53MP0005671_abnormal_response_to1.37163624
54MP0000631_abnormal_neuroendocrine_gland1.36716837
55MP0001970_abnormal_pain_threshold1.34683561
56MP0003252_abnormal_bile_duct1.33484208
57MP0008875_abnormal_xenobiotic_pharmacok1.32494316
58MP0004130_abnormal_muscle_cell1.31534901
59MP0001986_abnormal_taste_sensitivity1.30887019
60MP0006082_CNS_inflammation1.30279882
61MP0004142_abnormal_muscle_tone1.27898102
62MP0005075_abnormal_melanosome_morpholog1.27464251
63MP0009115_abnormal_fat_cell1.26912374
64MP0004885_abnormal_endolymph1.25526546
65MP0002572_abnormal_emotion/affect_behav1.24490293
66MP0005167_abnormal_blood-brain_barrier1.24012742
67MP0000383_abnormal_hair_follicle1.23852974
68MP0001756_abnormal_urination1.23661410
69MP0000678_abnormal_parathyroid_gland1.23321879
70MP0001188_hyperpigmentation1.22400816
71MP0002234_abnormal_pharynx_morphology1.22015733
72MP0000538_abnormal_urinary_bladder1.21442625
73MP0006292_abnormal_olfactory_placode1.18809431
74MP0005334_abnormal_fat_pad1.14890648
75MP0002733_abnormal_thermal_nociception1.14224137
76MP0004147_increased_porphyrin_level1.14168231
77MP0002557_abnormal_social/conspecific_i1.13436245
78MP0004742_abnormal_vestibular_system1.12748638
79MP0005410_abnormal_fertilization1.12264686
80MP0002064_seizures1.11754720
81MP0000230_abnormal_systemic_arterial1.11473238
82MP0002095_abnormal_skin_pigmentation1.10336642
83MP0001765_abnormal_ion_homeostasis1.10018113
84MP0004019_abnormal_vitamin_homeostasis1.09317773
85MP0001905_abnormal_dopamine_level1.07895079
86MP0000569_abnormal_digit_pigmentation1.07322192
87MP0003938_abnormal_ear_development1.06799513
88MP0005423_abnormal_somatic_nervous1.06313051
89MP0008438_abnormal_cutaneous_collagen1.06132591
90MP0009763_increased_sensitivity_to1.06021076
91MP0002693_abnormal_pancreas_physiology1.04575890
92MP0004133_heterotaxia1.04287642
93MP0005636_abnormal_mineral_homeostasis1.03314301
94MP0002067_abnormal_sensory_capabilities1.00920523
95MP0002139_abnormal_hepatobiliary_system0.99438718
96MP0009643_abnormal_urine_homeostasis0.99311373
97MP0005083_abnormal_biliary_tract0.98477384
98MP0010329_abnormal_lipoprotein_level0.98280795
99MP0003011_delayed_dark_adaptation0.98169804
100MP0005195_abnormal_posterior_eye0.98055318
101MP0005387_immune_system_phenotype0.97515102
102MP0001790_abnormal_immune_system0.97515102
103MP0001835_abnormal_antigen_presentation0.96836085
104MP0004215_abnormal_myocardial_fiber0.96200724
105MP0001963_abnormal_hearing_physiology0.95677851
106MP0002970_abnormal_white_adipose0.93935920
107MP0009764_decreased_sensitivity_to0.93719247
108MP0003879_abnormal_hair_cell0.93381989
109MP0003045_fibrosis0.92377126
110MP0003283_abnormal_digestive_organ0.91393084
111MP0002928_abnormal_bile_duct0.91108141
112MP0005332_abnormal_amino_acid0.90725609
113MP0009785_altered_susceptibility_to0.90335014
114MP0002060_abnormal_skin_morphology0.89792622
115MP0002752_abnormal_somatic_nervous0.89402069
116MP0002148_abnormal_hypersensitivity_rea0.87947859
117MP0001968_abnormal_touch/_nociception0.87534135
118MP0002653_abnormal_ependyma_morphology0.86685401
119MP0003633_abnormal_nervous_system0.85935846
120MP0002909_abnormal_adrenal_gland0.85008452
121MP0001944_abnormal_pancreas_morphology0.84820243
122MP0003698_abnormal_male_reproductive0.84801232
123MP0003635_abnormal_synaptic_transmissio0.84464475
124MP0005646_abnormal_pituitary_gland0.84143524
125MP0002734_abnormal_mechanical_nocicepti0.84135726
126MP0000537_abnormal_urethra_morphology0.83674303
127MP0002136_abnormal_kidney_physiology0.83354297
128MP0002090_abnormal_vision0.81740789
129MP0003191_abnormal_cellular_cholesterol0.81486769
130MP0003566_abnormal_cell_adhesion0.80795386
131MP0002006_tumorigenesis0.80670897
132MP0002138_abnormal_hepatobiliary_system0.80589745
133MP0002063_abnormal_learning/memory/cond0.80558535
134MP0003718_maternal_effect0.80104754
135MP0008260_abnormal_autophagy0.80097282
136MP0001529_abnormal_vocalization0.78879188
137MP0005365_abnormal_bile_salt0.77790587
138MP0004947_skin_inflammation0.76268693
139MP0002163_abnormal_gland_morphology0.74969400
140MP0000858_altered_metastatic_potential0.73605560
141MP0001119_abnormal_female_reproductive0.72259179
142MP0002118_abnormal_lipid_homeostasis0.72029273
143MP0005584_abnormal_enzyme/coenzyme_acti0.71458534
144MP0004185_abnormal_adipocyte_glucose0.71369267
145MP0008872_abnormal_physiological_respon0.70718395
146MP0003693_abnormal_embryo_hatching0.70712061
147MP0008877_abnormal_DNA_methylation0.70338169
148MP0008775_abnormal_heart_ventricle0.69160519
149MP0000015_abnormal_ear_pigmentation0.68131907
150MP0003724_increased_susceptibility_to0.66334313
151MP0001929_abnormal_gametogenesis0.65603135
152MP0005535_abnormal_body_temperature0.63854137
153MP0002229_neurodegeneration0.60942679
154MP0008058_abnormal_DNA_repair0.59164209
155MP0000026_abnormal_inner_ear0.57959531
156MP0001845_abnormal_inflammatory_respons0.57702057
157MP0002168_other_aberrant_phenotype0.57672869
158MP0004858_abnormal_nervous_system0.56120050
159MP0002419_abnormal_innate_immunity0.55492838
160MP0010094_abnormal_chromosome_stability0.55156057
161MP0009333_abnormal_splenocyte_physiolog0.54848455
162MP0002971_abnormal_brown_adipose0.53773298
163MP0004043_abnormal_pH_regulation0.51885711
164MP0003699_abnormal_female_reproductive0.51797345
165MP0003786_premature_aging0.49348590

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fovea (HP:0000493)8.87940547
2Abnormal rod and cone electroretinograms (HP:0008323)7.96983998
3Choroideremia (HP:0001139)7.65115515
4Bony spicule pigmentary retinopathy (HP:0007737)6.73090835
5Vacuolated lymphocytes (HP:0001922)6.43695018
611 pairs of ribs (HP:0000878)6.18106121
7Recurrent gram-negative bacterial infections (HP:0005420)4.75562948
8Complement deficiency (HP:0004431)4.64246978
9Congenital stationary night blindness (HP:0007642)4.62672329
10Hypopigmentation of the fundus (HP:0007894)4.54102014
11Tongue fasciculations (HP:0001308)4.32002934
12Pancreatic cysts (HP:0001737)4.20837931
13Hand muscle atrophy (HP:0009130)4.13525614
14Thyroid-stimulating hormone excess (HP:0002925)4.02610437
15Abnormality of midbrain morphology (HP:0002418)3.95152832
16Molar tooth sign on MRI (HP:0002419)3.95152832
17Nephronophthisis (HP:0000090)3.90761359
18Missing ribs (HP:0000921)3.84312298
19Muscle fibrillation (HP:0010546)3.83698963
20Pancreatic fibrosis (HP:0100732)3.79723243
21True hermaphroditism (HP:0010459)3.78655860
22Hyperphosphatemia (HP:0002905)3.75034998
23Nonprogressive disorder (HP:0003680)3.74651041
24Abnormality of the renal cortex (HP:0011035)3.71107602
25Hyperglycinemia (HP:0002154)3.53099742
26Chromsome breakage (HP:0040012)3.49372636
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.39044109
28Tubular atrophy (HP:0000092)3.38183944
29Abnormality of the renal medulla (HP:0100957)3.36683481
30Stridor (HP:0010307)3.35500564
31Duplicated collecting system (HP:0000081)3.34948150
32Attenuation of retinal blood vessels (HP:0007843)3.33251130
33Clumsiness (HP:0002312)3.31604702
34Abnormality of complement system (HP:0005339)3.30244178
35Facial diplegia (HP:0001349)3.18475990
36Gaze-evoked nystagmus (HP:0000640)3.16547926
37Facial shape deformation (HP:0011334)3.15769601
38Potter facies (HP:0002009)3.15769601
39Medial flaring of the eyebrow (HP:0010747)3.15303351
40Metaphyseal cupping (HP:0003021)3.13323836
41Vascular calcification (HP:0004934)3.06941331
42Absent rod-and cone-mediated responses on ERG (HP:0007688)3.06286072
43Abnormality of the calcaneus (HP:0008364)3.04592081
44Reticulocytopenia (HP:0001896)3.04349557
45Oligomenorrhea (HP:0000876)3.03586984
46Hyperglycinuria (HP:0003108)3.01050346
47Polydipsia (HP:0001959)3.00450654
48Abnormal drinking behavior (HP:0030082)3.00450654
49Distal upper limb amyotrophy (HP:0007149)2.87677344
50Upper limb amyotrophy (HP:0009129)2.87677344
51Hyperventilation (HP:0002883)2.80251687
52Cardiovascular calcification (HP:0011915)2.77484950
53Abnormality of macular pigmentation (HP:0008002)2.77177166
54Abnormality of the renal collecting system (HP:0004742)2.76069482
55Severe visual impairment (HP:0001141)2.75991219
56Loss of speech (HP:0002371)2.75084152
57Chronic hepatic failure (HP:0100626)2.69721914
58Hyperthyroidism (HP:0000836)2.68128707
59Renal cortical cysts (HP:0000803)2.68114988
60Decreased central vision (HP:0007663)2.66878062
613-Methylglutaconic aciduria (HP:0003535)2.66265028
62Action tremor (HP:0002345)2.64981773
63Cystic liver disease (HP:0006706)2.64761404
64Progressive cerebellar ataxia (HP:0002073)2.64480515
65Aplasia/Hypoplasia of the fovea (HP:0008060)2.62586022
66Hypoplasia of the fovea (HP:0007750)2.62586022
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61977390
68Diaphragmatic weakness (HP:0009113)2.61051339
69Type II lissencephaly (HP:0007260)2.59183893
70Impulsivity (HP:0100710)2.57539148
71Dysostosis multiplex (HP:0000943)2.56550673
72Gait imbalance (HP:0002141)2.45088595
73Intestinal atresia (HP:0011100)2.42529927
74Congenital sensorineural hearing impairment (HP:0008527)2.42010848
75Congenital primary aphakia (HP:0007707)2.41871925
76Abnormality of serine family amino acid metabolism (HP:0010894)2.40787654
77Abnormality of glycine metabolism (HP:0010895)2.40787654
78Nephrogenic diabetes insipidus (HP:0009806)2.36778929
79Abnormal hair whorl (HP:0010721)2.36076639
80Neurofibrillary tangles (HP:0002185)2.35901311
81Methylmalonic acidemia (HP:0002912)2.34367916
82Keratoconus (HP:0000563)2.31479412
83Increased corneal curvature (HP:0100692)2.31479412
84Hypoplastic iliac wings (HP:0002866)2.31145176
85Polyuria (HP:0000103)2.28176920
86Lipid accumulation in hepatocytes (HP:0006561)2.27447177
87Hypertriglyceridemia (HP:0002155)2.25799952
88Mitochondrial inheritance (HP:0001427)2.24767481
89Methylmalonic aciduria (HP:0012120)2.24285581
90Myopathic facies (HP:0002058)2.23274968
91Thrombocytosis (HP:0001894)2.22790792
92Elevated erythrocyte sedimentation rate (HP:0003565)2.20188870
93Proximal tubulopathy (HP:0000114)2.19925509
94Tubulointerstitial fibrosis (HP:0005576)2.19343527
95Increased CSF lactate (HP:0002490)2.18004703
96Subcapsular cataract (HP:0000523)2.17877876
97Sclerocornea (HP:0000647)2.17790730
98Cortical dysplasia (HP:0002539)2.16974207
99Large for gestational age (HP:0001520)2.16356463
100Pigmentary retinal degeneration (HP:0001146)2.15620001
101Albinism (HP:0001022)2.15177632
102Dynein arm defect of respiratory motile cilia (HP:0012255)2.14656406
103Absent/shortened dynein arms (HP:0200106)2.14656406
104Increased hepatocellular lipid droplets (HP:0006565)2.14063909
105Progressive macrocephaly (HP:0004481)2.13909309
106Aplasia/Hypoplasia of the tongue (HP:0010295)2.13860995
107Furrowed tongue (HP:0000221)2.13381291
108Acute necrotizing encephalopathy (HP:0006965)2.12921041
109Hypothermia (HP:0002045)2.10606887
110Decreased circulating renin level (HP:0003351)2.10474554
111Abnormality of alanine metabolism (HP:0010916)2.08925591
112Broad-based gait (HP:0002136)2.07902312
113Hypergonadotropic hypogonadism (HP:0000815)2.06489484
114Genetic anticipation (HP:0003743)2.05822374
115Intention tremor (HP:0002080)2.03033273
116Abnormality of urine glucose concentration (HP:0011016)2.02382520
117Glycosuria (HP:0003076)2.02382520
118Abnormality of macrophages (HP:0004311)2.02219092
119Reduced subcutaneous adipose tissue (HP:0003758)2.02097944
120Agitation (HP:0000713)2.01850684
121Congenital hepatic fibrosis (HP:0002612)2.00720128
122Anencephaly (HP:0002323)1.99496455
123Azoospermia (HP:0000027)1.97303452
124Cerebellar dysplasia (HP:0007033)1.96447249
125Genital tract atresia (HP:0001827)1.95429267
126Retinal dysplasia (HP:0007973)1.95176380
127Thyroiditis (HP:0100646)1.94827698
128Febrile seizures (HP:0002373)1.94323742
129Inability to walk (HP:0002540)1.94124439
130Abnormal respiratory epithelium morphology (HP:0012253)1.92844074
131Abnormal respiratory motile cilium morphology (HP:0005938)1.92844074
132Acute encephalopathy (HP:0006846)1.92131381
133Ileus (HP:0002595)1.91645135
134Central scotoma (HP:0000603)1.91238095
135Postaxial foot polydactyly (HP:0001830)1.90821382
136Vaginal atresia (HP:0000148)1.89355906
137Renal Fanconi syndrome (HP:0001994)1.88841196
138Long foot (HP:0001833)1.86560265
139Focal motor seizures (HP:0011153)1.86308828
140Cerebral inclusion bodies (HP:0100314)1.85423768
141Ketoacidosis (HP:0001993)1.84279427
142Abnormal respiratory motile cilium physiology (HP:0012261)1.83288278
143Rectal prolapse (HP:0002035)1.83188963
144Lissencephaly (HP:0001339)1.83122571
145Focal seizures (HP:0007359)1.82904543
146Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82825286
147Bile duct proliferation (HP:0001408)1.82809225
148Abnormal biliary tract physiology (HP:0012439)1.82809225
149Hemiplegia (HP:0002301)1.82799851
150Ectopia lentis (HP:0001083)1.81726340
151Tubulointerstitial nephritis (HP:0001970)1.81605608
152Retinitis pigmentosa (HP:0000510)1.81300180
153Autoimmune thrombocytopenia (HP:0001973)1.80851087
154Pendular nystagmus (HP:0012043)1.80121820
155Dialeptic seizures (HP:0011146)1.80045871
156Ankle clonus (HP:0011448)1.80024949
157Postaxial hand polydactyly (HP:0001162)1.79762326
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.79407007
159Abnormal urine output (HP:0012590)1.79094938
160Constricted visual fields (HP:0001133)1.78733781
161Abnormal hemoglobin (HP:0011902)1.78655845
162Tubulointerstitial abnormality (HP:0001969)1.78457056
163Infertility (HP:0000789)1.78305262
164Ketosis (HP:0001946)1.78034676
165Disproportionate short-trunk short stature (HP:0003521)1.77587169
166Systemic lupus erythematosus (HP:0002725)1.77064181
167Hyperpituitarism (HP:0010514)1.76878574
168Horseshoe kidney (HP:0000085)1.76459840
169Bulbar palsy (HP:0001283)1.75854723
170Progressive inability to walk (HP:0002505)1.74975332
171Male pseudohermaphroditism (HP:0000037)1.74948968
172Hemiparesis (HP:0001269)1.74415964
173Progressive visual loss (HP:0000529)1.72878499
174Aplasia of the musculature (HP:0100854)1.71498652
175Abnormal spermatogenesis (HP:0008669)1.67922111
176Focal segmental glomerulosclerosis (HP:0000097)1.64889424
177Abnormality of the vocal cords (HP:0008777)1.60290331
178Seborrheic dermatitis (HP:0001051)1.60064194
179Restlessness (HP:0000711)1.58832620
180Wide cranial sutures (HP:0010537)1.58641553
181Dyschromatopsia (HP:0007641)1.58223429
182Abolished electroretinogram (ERG) (HP:0000550)1.58051395
183Macular degeneration (HP:0000608)1.56587182
184Abnormality of mucopolysaccharide metabolism (HP:0011020)1.56010274
185Abnormality of polysaccharide metabolism (HP:0011012)1.56010274
186Abnormality of glycosaminoglycan metabolism (HP:0004371)1.56010274
187Hyperalaninemia (HP:0003348)1.53451250
188Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.53451250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK17.34409075
2TAOK35.21796879
3IRAK33.78397956
4ADRBK23.23492721
5TLK13.15000886
6AKT33.09056899
7LMTK23.07812053
8NUAK12.74156901
9MAP3K132.64456339
10MAP4K22.63176278
11MAP3K92.61923572
12MYLK2.43659542
13SIK12.33233409
14MAP2K72.15593005
15TTK2.04232912
16RIPK41.99952365
17MAP3K61.96760713
18WNK31.84334653
19MAP2K61.82568160
20INSRR1.78864383
21BMPR1B1.76578811
22IRAK41.71353844
23JAK31.70812642
24IRAK11.61487408
25EIF2AK21.55700237
26FGFR21.53301393
27ZAK1.48394835
28TEC1.46074452
29OXSR11.43294313
30MAP2K41.42626405
31FLT31.39122692
32CAMKK21.35768785
33IRAK21.35099796
34CDK191.31569175
35BRSK21.30206611
36PTK2B1.28941213
37STK391.27393793
38PAK31.26554889
39MAP3K141.25776897
40TXK1.20380834
41STK31.20141598
42PDK31.18489587
43PDK41.18489587
44NTRK31.18141673
45TIE11.17800080
46TRIM281.13884297
47WNK41.12631494
48TNK21.10933713
49MAP3K41.10874456
50FRK1.09049087
51MUSK1.07011981
52BCKDK1.00647775
53LATS10.97176723
54PDK20.96462102
55BCR0.92899085
56MKNK20.91116579
57STK160.90679486
58GRK10.88697375
59DAPK20.88519386
60PRKD30.88404478
61CSNK1G10.85743560
62BMPR20.81602155
63JAK10.78875861
64PHKG10.73865786
65PHKG20.73865786
66NTRK20.73830308
67EEF2K0.73306914
68BMX0.72057006
69TNIK0.69459546
70LATS20.69115575
71CSNK1G30.68599164
72JAK20.66958019
73MAP3K120.66894964
74TGFBR10.65283578
75MOS0.63510922
76ATR0.62919361
77VRK10.62085909
78CSNK1G20.61810179
79ITK0.61128230
80CAMK10.60498236
81TBK10.60192154
82ERBB30.59316851
83ARAF0.58365948
84CCNB10.58016413
85FER0.57680193
86MAPK130.56834431
87PRKAA20.56594793
88STK110.55552076
89CAMK2A0.55424555
90PNCK0.54745142
91CASK0.54219160
92CSNK1A1L0.51154804
93PINK10.50750825
94PLK20.50582522
95GRK70.48673950
96ERBB40.48430114
97YES10.47553848
98EIF2AK30.45526298
99MAPKAPK30.44714681
100PLK30.43310290
101NEK20.42144314
102CSNK1A10.41640415
103PKN10.41557050
104PRKACA0.41472822
105MKNK10.41346012
106PRKCQ0.41262597
107ACVR1B0.40522660
108SGK10.40232279
109PRKAA10.40147619
110MAPKAPK50.39561731
111MST40.37833722
112PRKCZ0.37355762
113EPHB10.36875220
114PRKG10.36197373
115PLK40.35957340
116SGK20.34363987
117PRKCD0.34236935
118DAPK10.33903648
119ADRBK10.33901638
120KIT0.33844116
121PRKCA0.32993316
122ALK0.32385614
123CHUK0.32314521
124MARK30.30542222
125ROCK10.30482791
126PIK3CA0.30153759
127NTRK10.29674936
128CSNK1D0.28971819
129BLK0.28622305
130PTK20.27923265
131CDK30.27436312
132OBSCN0.27397748
133MAPK30.26912446
134PRKCG0.26659906
135PRKCH0.26444584
136PRKCI0.25940261
137PRKCB0.23519454
138GRK50.22570669
139PRKCE0.22568867
140PTK60.22058407
141CAMK1G0.21606679
142BRAF0.21416909
143MAPK120.21142225
144TSSK60.21114688
145DYRK20.20509747
146STK38L0.20386871
147PAK20.19770839
148PIK3CG0.19512379
149FGFR40.19200267
150NLK0.19166648
151IKBKB0.18895874
152LYN0.18439216
153MAPK10.18091558
154CSF1R0.17458163
155BTK0.17381322
156PLK10.17142152
157SRC0.16795747
158IGF1R0.15795170
159ERN10.15329888
160MAP2K10.15303013

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005115.01259069
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.70546123
3ABC transporters_Homo sapiens_hsa020103.69834321
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.53111322
5Vitamin B6 metabolism_Homo sapiens_hsa007503.13724613
6Phototransduction_Homo sapiens_hsa047442.67438476
7Fatty acid metabolism_Homo sapiens_hsa012122.65032405
8Butanoate metabolism_Homo sapiens_hsa006502.64752633
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.62687246
10Sulfur metabolism_Homo sapiens_hsa009202.61153930
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.55571556
12PPAR signaling pathway_Homo sapiens_hsa033202.31423239
13Protein export_Homo sapiens_hsa030602.26855849
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17594435
15Nitrogen metabolism_Homo sapiens_hsa009102.17314988
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16468521
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.11974669
18Glycerolipid metabolism_Homo sapiens_hsa005612.09601967
19Fatty acid biosynthesis_Homo sapiens_hsa000612.06914778
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01795281
21Phenylalanine metabolism_Homo sapiens_hsa003601.96082186
22Ether lipid metabolism_Homo sapiens_hsa005651.93921231
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92869887
24Arachidonic acid metabolism_Homo sapiens_hsa005901.91783770
25Fatty acid degradation_Homo sapiens_hsa000711.91006540
26Caffeine metabolism_Homo sapiens_hsa002321.89112392
27One carbon pool by folate_Homo sapiens_hsa006701.87128005
28Lysosome_Homo sapiens_hsa041421.85403230
29beta-Alanine metabolism_Homo sapiens_hsa004101.85012539
30Nicotine addiction_Homo sapiens_hsa050331.84702477
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83406923
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81902580
33Vitamin digestion and absorption_Homo sapiens_hsa049771.80194440
34Tyrosine metabolism_Homo sapiens_hsa003501.78184150
35Homologous recombination_Homo sapiens_hsa034401.74487565
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70941664
37Oxidative phosphorylation_Homo sapiens_hsa001901.70183815
38Autoimmune thyroid disease_Homo sapiens_hsa053201.68087851
39Olfactory transduction_Homo sapiens_hsa047401.63681731
40Salivary secretion_Homo sapiens_hsa049701.55823839
41Retinol metabolism_Homo sapiens_hsa008301.52621503
42Basal transcription factors_Homo sapiens_hsa030221.50822311
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43800071
44Graft-versus-host disease_Homo sapiens_hsa053321.40685969
45Sphingolipid metabolism_Homo sapiens_hsa006001.39823207
46Propanoate metabolism_Homo sapiens_hsa006401.39211116
47Staphylococcus aureus infection_Homo sapiens_hsa051501.32297571
48Selenocompound metabolism_Homo sapiens_hsa004501.29585502
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29466388
50Ovarian steroidogenesis_Homo sapiens_hsa049131.21614730
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21381102
52GABAergic synapse_Homo sapiens_hsa047271.21331170
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.21285277
54Parkinsons disease_Homo sapiens_hsa050121.20846942
55Linoleic acid metabolism_Homo sapiens_hsa005911.19835291
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18690079
57Type I diabetes mellitus_Homo sapiens_hsa049401.18005617
58Insulin secretion_Homo sapiens_hsa049111.16172703
59Chemical carcinogenesis_Homo sapiens_hsa052041.15501167
60RNA degradation_Homo sapiens_hsa030181.15237134
61Collecting duct acid secretion_Homo sapiens_hsa049661.14042305
62Serotonergic synapse_Homo sapiens_hsa047261.11598205
63NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10984894
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.07877595
65RNA polymerase_Homo sapiens_hsa030201.07494746
66Glutamatergic synapse_Homo sapiens_hsa047241.06274399
67Regulation of autophagy_Homo sapiens_hsa041401.03929901
68Thyroid hormone synthesis_Homo sapiens_hsa049181.03652402
69Allograft rejection_Homo sapiens_hsa053301.03621844
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01223998
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00794838
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97175766
73Circadian entrainment_Homo sapiens_hsa047130.95237446
74Fanconi anemia pathway_Homo sapiens_hsa034600.92938729
75Circadian rhythm_Homo sapiens_hsa047100.91173436
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89645316
77Primary immunodeficiency_Homo sapiens_hsa053400.89402410
78Prion diseases_Homo sapiens_hsa050200.88167566
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85982613
80p53 signaling pathway_Homo sapiens_hsa041150.83062973
81Taste transduction_Homo sapiens_hsa047420.81826781
82Pertussis_Homo sapiens_hsa051330.80939397
83Huntingtons disease_Homo sapiens_hsa050160.80799740
84Non-homologous end-joining_Homo sapiens_hsa034500.79039550
85Complement and coagulation cascades_Homo sapiens_hsa046100.78392599
86Cardiac muscle contraction_Homo sapiens_hsa042600.77864679
87Proteasome_Homo sapiens_hsa030500.74918395
88Vibrio cholerae infection_Homo sapiens_hsa051100.73908621
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72011487
90Base excision repair_Homo sapiens_hsa034100.71372951
91Alzheimers disease_Homo sapiens_hsa050100.70800044
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69461512
93Asthma_Homo sapiens_hsa053100.67187467
94Metabolic pathways_Homo sapiens_hsa011000.65276714
95Dorso-ventral axis formation_Homo sapiens_hsa043200.63109054
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62796731
97Renin secretion_Homo sapiens_hsa049240.61199642
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.61138153
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60518630
100Herpes simplex infection_Homo sapiens_hsa051680.60267223
101Calcium signaling pathway_Homo sapiens_hsa040200.60208000
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58121985
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57569454
104Biosynthesis of amino acids_Homo sapiens_hsa012300.56961721
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56139081
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.54964230
107Influenza A_Homo sapiens_hsa051640.54187691
108Pyruvate metabolism_Homo sapiens_hsa006200.53823731
109Glutathione metabolism_Homo sapiens_hsa004800.53722142
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53612077
111Protein digestion and absorption_Homo sapiens_hsa049740.52636137
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.52152789
113Dopaminergic synapse_Homo sapiens_hsa047280.48957998
114Peroxisome_Homo sapiens_hsa041460.48028644
115Leishmaniasis_Homo sapiens_hsa051400.47462824
116Pancreatic secretion_Homo sapiens_hsa049720.46479460
117Arginine and proline metabolism_Homo sapiens_hsa003300.46113582
118Carbon metabolism_Homo sapiens_hsa012000.44695317
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44594170
120Histidine metabolism_Homo sapiens_hsa003400.44566030
121Rheumatoid arthritis_Homo sapiens_hsa053230.43991941
122Tryptophan metabolism_Homo sapiens_hsa003800.43509228
123cAMP signaling pathway_Homo sapiens_hsa040240.43475380
124Long-term depression_Homo sapiens_hsa047300.42090341
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.42063875
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40107723
127Fatty acid elongation_Homo sapiens_hsa000620.39296294
128Cell cycle_Homo sapiens_hsa041100.38317271
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.38194029
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34496017
131Purine metabolism_Homo sapiens_hsa002300.33785534
132Measles_Homo sapiens_hsa051620.33691860
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33328118
134Oxytocin signaling pathway_Homo sapiens_hsa049210.33172246
135Morphine addiction_Homo sapiens_hsa050320.32127448
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30563685
137African trypanosomiasis_Homo sapiens_hsa051430.29812534
138Fat digestion and absorption_Homo sapiens_hsa049750.27933707
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.27633487
140Folate biosynthesis_Homo sapiens_hsa007900.27444950
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26792825
142Ribosome_Homo sapiens_hsa030100.26628549
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26627521
144Hepatitis C_Homo sapiens_hsa051600.25474066
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22875456
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.22484662
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22475625
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19798320
149Toxoplasmosis_Homo sapiens_hsa051450.19134044
150Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18952302
151Pentose phosphate pathway_Homo sapiens_hsa000300.18247031
152NF-kappa B signaling pathway_Homo sapiens_hsa040640.17692179
153Prolactin signaling pathway_Homo sapiens_hsa049170.17369119
154TNF signaling pathway_Homo sapiens_hsa046680.14972737
155GnRH signaling pathway_Homo sapiens_hsa049120.14360497
156Phagosome_Homo sapiens_hsa041450.13379159

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