ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of antigen processing and presentation (GO:0002579)	7.48913644
2	regulation of acrosome reaction (GO:0060046)	6.94728954
3	negative regulation of receptor-mediated endocytosis (GO:0048261)	6.94634418
4	fusion of sperm to egg plasma membrane (GO:0007342)	6.18092566
5	regulation of antigen processing and presentation (GO:0002577)	5.82934480
6	complement activation, alternative pathway (GO:0006957)	5.49181454
7	sulfur amino acid catabolic process (GO:0000098)	4.92255246
8	regulation of Cdc42 GTPase activity (GO:0043088)	4.81282831
9	plasma membrane fusion (GO:0045026)	4.77219153
10	macroautophagy (GO:0016236)	4.56131362
11	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.33958582
12	regulation of hydrogen peroxide metabolic process (GO:0010310)	3.87788978
13	response to misfolded protein (GO:0051788)	3.78318406
14	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	3.74264979
15	ethanol metabolic process (GO:0006067)	3.64914452
16	primary alcohol catabolic process (GO:0034310)	3.51817369
17	GPI anchor biosynthetic process (GO:0006506)	3.50664310
18	alpha-linolenic acid metabolic process (GO:0036109)	3.46641841
19	negative regulation of endopeptidase activity (GO:0010951)	3.46188331
20	positive regulation of glomerulus development (GO:0090193)	3.40841867
21	ethanol oxidation (GO:0006069)	3.40574763
22	negative regulation of metanephros development (GO:0072217)	3.35617355
23	cellular sodium ion homeostasis (GO:0006883)	3.33142981
24	brown fat cell differentiation (GO:0050873)	3.33010804
25	valine metabolic process (GO:0006573)	3.32095882
26	positive regulation of response to oxidative stress (GO:1902884)	3.32033569
27	positive regulation of cellular response to oxidative stress (GO:1900409)	3.32033569
28	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.31522072
29	negative regulation of peptidase activity (GO:0010466)	3.31214175
30	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.30778241
31	negative regulation of endocytosis (GO:0045806)	3.30253038
32	low-density lipoprotein particle clearance (GO:0034383)	3.22756582
33	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.19406790
34	GPI anchor metabolic process (GO:0006505)	3.18128397
35	tonic smooth muscle contraction (GO:0014820)	3.17593342
36	carnitine transmembrane transport (GO:1902603)	3.12880780
37	triglyceride catabolic process (GO:0019433)	3.10782696
38	response to nitrosative stress (GO:0051409)	3.08191370
39	positive regulation of receptor biosynthetic process (GO:0010870)	3.06473836
40	white fat cell differentiation (GO:0050872)	3.02480108
41	regulation of complement activation (GO:0030449)	3.02227850
42	carnitine transport (GO:0015879)	2.98636184
43	amino-acid betaine transport (GO:0015838)	2.98636184
44	respiratory burst (GO:0045730)	2.97665026
45	cytolysis (GO:0019835)	2.92254960
46	acylglycerol catabolic process (GO:0046464)	2.89902398
47	neutral lipid catabolic process (GO:0046461)	2.89902398
48	artery smooth muscle contraction (GO:0014824)	2.87957961
49	metanephric tubule development (GO:0072170)	2.86835290
50	metanephric nephron tubule development (GO:0072234)	2.86835290
51	regulation of protein activation cascade (GO:2000257)	2.85172371
52	negative regulation of lipase activity (GO:0060192)	2.83119522
53	C21-steroid hormone metabolic process (GO:0008207)	2.72298120
54	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.68307669
55	regulation of histone H3-K27 methylation (GO:0061085)	2.66333356
56	glycerolipid catabolic process (GO:0046503)	2.62331992
57	metanephric nephron epithelium development (GO:0072243)	2.61232147
58	L-serine metabolic process (GO:0006563)	2.57972663
59	phospholipid homeostasis (GO:0055091)	2.57855690
60	positive regulation of vesicle fusion (GO:0031340)	2.57514318
61	regulation of lipoprotein metabolic process (GO:0050746)	2.55641712
62	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.55379581
63	prostaglandin biosynthetic process (GO:0001516)	2.54881457
64	prostanoid biosynthetic process (GO:0046457)	2.54881457
65	cysteine metabolic process (GO:0006534)	2.54308944
66	adaptation of signaling pathway (GO:0023058)	2.51202924
67	regulation of receptor biosynthetic process (GO:0010869)	2.50440424
68	epithelial cell differentiation involved in kidney development (GO:0035850)	2.49626473
69	negative regulation of protein autophosphorylation (GO:0031953)	2.47861877
70	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.46973757
71	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.46725905
72	positive regulation of sterol transport (GO:0032373)	2.46059406
73	positive regulation of cholesterol transport (GO:0032376)	2.46059406
74	sodium ion homeostasis (GO:0055078)	2.44072045
75	nerve growth factor signaling pathway (GO:0038180)	2.43730389
76	positive regulation of fatty acid biosynthetic process (GO:0045723)	2.41013988
77	regulation of bile acid biosynthetic process (GO:0070857)	2.40327733
78	cellular modified amino acid catabolic process (GO:0042219)	2.38633625
79	mannose metabolic process (GO:0006013)	2.38611272
80	prostanoid metabolic process (GO:0006692)	2.37633265
81	prostaglandin metabolic process (GO:0006693)	2.37633265
82	nephron tubule development (GO:0072080)	2.37591567
83	positive regulation of digestive system process (GO:0060456)	2.37161385
84	negative regulation of proteolysis (GO:0045861)	2.36629715
85	quaternary ammonium group transport (GO:0015697)	2.33629154
86	xenobiotic catabolic process (GO:0042178)	2.31146673
87	oxaloacetate metabolic process (GO:0006107)	2.30791365
88	metanephric epithelium development (GO:0072207)	2.30646818
89	cell differentiation involved in metanephros development (GO:0072202)	2.30624715
90	negative regulation of kidney development (GO:0090185)	2.29209488
91	fatty acid beta-oxidation (GO:0006635)	2.28481703
92	negative regulation of protein processing (GO:0010955)	2.27917709
93	negative regulation of protein maturation (GO:1903318)	2.27917709
94	triglyceride biosynthetic process (GO:0019432)	2.27785329
95	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	16.9649524
96	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	16.9649524
97	antigen processing and presentation via MHC class Ib (GO:0002475)	16.0995029
98	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	15.2605314
99	antigen processing and presentation of endogenous antigen (GO:0019883)	14.0670367
100	regulation of clathrin-mediated endocytosis (GO:2000369)	10.4187899

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	9.79736626
2	TP63_17297297_ChIP-ChIP_HaCaT_Human	6.28350083
3	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.78623252
4	ZNF263_19887448_ChIP-Seq_K562_Human	3.88436531
5	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.04854713
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.92819654
7	AR_21572438_ChIP-Seq_LNCaP_Human	2.87658046
8	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.27305692
9	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.10114476
10	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.98633397
11	CLOCK_20551151_ChIP-Seq_293T_Human	1.98364014
12	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.97052111
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94652561
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.65699854
15	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.59844879
16	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.55936331
17	EZH2_22144423_ChIP-Seq_EOC_Human	1.50921784
18	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.46220186
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.40419137
20	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.40169401
21	LXR_22292898_ChIP-Seq_THP-1_Human	1.35503847
22	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.33934269
23	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.33824657
24	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.33049794
25	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.33049794
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.30525279
27	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.29979278
28	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.25239474
29	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.24011513
30	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.19467091
31	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.18559778
32	SOX2_20726797_ChIP-Seq_SW620_Human	1.18056118
33	MYC_19915707_ChIP-ChIP_AK7_Human	1.17508693
34	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.16948046
35	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.16454628
36	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.15919472
37	AHR_22903824_ChIP-Seq_MCF-7_Human	1.11089979
38	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.11055044
39	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.10758148
40	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.10635226
41	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.08445472
42	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.08413253
43	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.06744362
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06258634
45	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.05794266
46	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.05480231
47	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.05322625
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05313660
49	VDR_24787735_ChIP-Seq_THP-1_Human	1.05300356
50	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.03088081
51	STAT1_17558387_ChIP-Seq_HELA_Human	1.02845438
52	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.01298325
53	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.97622125
54	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.97607874
55	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.97290667
56	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96492408
57	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.96481747
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.96464139
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.96464139
60	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.96013543
61	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.95736235
62	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.95437516
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95032566
64	RNF2_27304074_Chip-Seq_NSC_Mouse	0.94923470
65	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.94377542
66	TP53_18474530_ChIP-ChIP_U2OS_Human	0.94293001
67	TP63_23658742_ChIP-Seq_EP156T_Human	0.93068094
68	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92365925
69	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.92311787
70	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.91740514
71	CEBPB_22108803_ChIP-Seq_LS180_Human	0.90760794
72	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.90436786
73	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.88870363
74	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.87226845
75	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.86567433
76	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.86491342
77	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.86051103
78	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.85099718
79	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.84119499
80	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.83582525
81	P68_20966046_ChIP-Seq_HELA_Human	0.83411488
82	BCAT_22108803_ChIP-Seq_LS180_Human	0.82794331
83	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.82745749
84	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.82267044
85	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.81785474
86	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.81785474
87	KDM2B_26808549_Chip-Seq_K562_Human	0.81307199
88	HTT_18923047_ChIP-ChIP_STHdh_Human	0.80906162
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.80893757
90	CJUN_26792858_Chip-Seq_BT549_Human	0.80508614
91	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.79075325
92	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.78806211
93	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.77716071
94	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.76962365
95	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.76817584
96	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.76159861
97	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.74884803
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.74250205
99	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.73971941
100	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.73782144

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005058_abnormal_lysosome_morphology	5.09015269
2	MP0004381_abnormal_hair_follicle	4.61462638
3	MP0002139_abnormal_hepatobiliary_system	4.01569555
4	MP0005670_abnormal_white_adipose	3.14655078
5	MP0002796_impaired_skin_barrier	2.88085262
6	MP0004185_abnormal_adipocyte_glucose	2.74292445
7	MP0003136_yellow_coat_color	2.67163488
8	MP0005666_abnormal_adipose_tissue	2.46564627
9	MP0003705_abnormal_hypodermis_morpholog	2.29412803
10	MP0002163_abnormal_gland_morphology	2.28135672
11	MP0004130_abnormal_muscle_cell	2.23528285
12	MP0009379_abnormal_foot_pigmentation	2.14846170
13	MP0005375_adipose_tissue_phenotype	2.14585024
14	MP0008004_abnormal_stomach_pH	2.11926374
15	MP0010329_abnormal_lipoprotein_level	2.09756468
16	MP0005379_endocrine/exocrine_gland_phen	2.07467605
17	MP0002254_reproductive_system_inflammat	1.97085843
18	MP0001501_abnormal_sleep_pattern	1.92907145
19	MP0003566_abnormal_cell_adhesion	1.90948077
20	MP0010234_abnormal_vibrissa_follicle	1.89257859
21	MP0000003_abnormal_adipose_tissue	1.88351672
22	MP0002837_dystrophic_cardiac_calcinosis	1.87532440
23	MP0005187_abnormal_penis_morphology	1.86217595
24	MP0005360_urolithiasis	1.84643531
25	MP0003195_calcinosis	1.74092875
26	MP0001727_abnormal_embryo_implantation	1.72285929
27	MP0005365_abnormal_bile_salt	1.71714782
28	MP0003300_gastrointestinal_ulcer	1.63133352
29	MP0004019_abnormal_vitamin_homeostasis	1.62823139
30	MP0001851_eye_inflammation	1.56342469
31	MP0000383_abnormal_hair_follicle	1.50906201
32	MP0010678_abnormal_skin_adnexa	1.48385496
33	MP0001765_abnormal_ion_homeostasis	1.46844282
34	MP0002118_abnormal_lipid_homeostasis	1.44610469
35	MP0010352_gastrointestinal_tract_polyps	1.43573955
36	MP0002138_abnormal_hepatobiliary_system	1.38723899
37	MP0000467_abnormal_esophagus_morphology	1.34214190
38	MP0002653_abnormal_ependyma_morphology	1.33120557
39	MP0008438_abnormal_cutaneous_collagen	1.32955680
40	MP0000427_abnormal_hair_cycle	1.26765189
41	MP0004858_abnormal_nervous_system	1.26087424
42	MP0003191_abnormal_cellular_cholesterol	1.23172864
43	MP0000751_myopathy	1.22812787
44	MP0002249_abnormal_larynx_morphology	1.22507626
45	MP0005501_abnormal_skin_physiology	1.19569651
46	MP0002234_abnormal_pharynx_morphology	1.19047585
47	MP0003453_abnormal_keratinocyte_physiol	1.16846547
48	MP0003690_abnormal_glial_cell	1.14131641
49	MP0003252_abnormal_bile_duct	1.11998866
50	MP0008875_abnormal_xenobiotic_pharmacok	1.11607272
51	MP0009763_increased_sensitivity_to	1.11391434
52	MP0005275_abnormal_skin_tensile	1.10544919
53	MP0004272_abnormal_basement_membrane	1.10483079
54	MP0010771_integument_phenotype	1.05917093
55	MP0000609_abnormal_liver_physiology	1.05763311
56	MP0002971_abnormal_brown_adipose	1.04741656
57	MP0003011_delayed_dark_adaptation	1.03642201
58	MP0008775_abnormal_heart_ventricle	1.00636560
59	MP0009643_abnormal_urine_homeostasis	0.99918284
60	MP0001216_abnormal_epidermal_layer	0.99722380
61	MP0002090_abnormal_vision	0.97468386
62	MP0002282_abnormal_trachea_morphology	0.97055189
63	MP0002909_abnormal_adrenal_gland	0.96777807
64	MP0002060_abnormal_skin_morphology	0.96249665
65	MP0005085_abnormal_gallbladder_physiolo	0.93537321
66	MP0008872_abnormal_physiological_respon	0.93290988
67	MP0005636_abnormal_mineral_homeostasis	0.92952864
68	MP0003075_altered_response_to	0.92894930
69	MP0000372_irregular_coat_pigmentation	0.89558482
70	MP0009780_abnormal_chondrocyte_physiolo	0.87817555
71	MP0002876_abnormal_thyroid_physiology	0.86951870
72	MP0003938_abnormal_ear_development	0.86109566
73	MP0004270_analgesia	0.85975024
74	MP0000750_abnormal_muscle_regeneration	0.85512029
75	MP0005451_abnormal_body_composition	0.83690812
76	MP0002098_abnormal_vibrissa_morphology	0.83396597
77	MP0004947_skin_inflammation	0.83333793
78	MP0002168_other_aberrant_phenotype	0.81883319
79	MP0010386_abnormal_urinary_bladder	0.80928327
80	MP0001177_atelectasis	0.80600379
81	MP0000537_abnormal_urethra_morphology	0.79912834
82	MP0005408_hypopigmentation	0.79312209
83	MP0006138_congestive_heart_failure	0.78794908
84	MP0008995_early_reproductive_senescence	0.78665044
85	MP0005164_abnormal_response_to	0.78029959
86	MP0005334_abnormal_fat_pad	0.77440538
87	MP0000013_abnormal_adipose_tissue	0.77085924
88	MP0005584_abnormal_enzyme/coenzyme_acti	0.74721997
89	MP0005332_abnormal_amino_acid	0.74622421
90	MP0001486_abnormal_startle_reflex	0.73494476
91	MP0001666_abnormal_nutrient_absorption	0.72799693
92	MP0002136_abnormal_kidney_physiology	0.72049752
93	MP0008961_abnormal_basal_metabolism	0.69471217
94	MP0000566_synostosis	0.69119802
95	MP0002970_abnormal_white_adipose	0.69102836
96	MP0004264_abnormal_extraembryonic_tissu	0.68922694
97	MP0003123_paternal_imprinting	0.66872078
98	MP0005535_abnormal_body_temperature	0.66856802
99	MP0008874_decreased_physiological_sensi	0.64866968
100	MP0009115_abnormal_fat_cell	0.63755602

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Choroideremia (HP:0001139)	8.25299634
2	Abnormality of the fovea (HP:0000493)	7.89354677
3	Abnormal rod and cone electroretinograms (HP:0008323)	6.62664670
4	Complement deficiency (HP:0004431)	6.12439819
5	Vacuolated lymphocytes (HP:0001922)	5.91537525
6	Bony spicule pigmentary retinopathy (HP:0007737)	5.59188258
7	11 pairs of ribs (HP:0000878)	4.98241859
8	Hypopigmentation of the fundus (HP:0007894)	4.72823929
9	Hand muscle atrophy (HP:0009130)	4.40438482
10	Abnormality of complement system (HP:0005339)	4.38710451
11	Action tremor (HP:0002345)	4.31351283
12	Recurrent gram-negative bacterial infections (HP:0005420)	3.96018735
13	Stridor (HP:0010307)	3.87383478
14	Neurofibrillary tangles (HP:0002185)	3.70873810
15	Upper limb amyotrophy (HP:0009129)	3.64489450
16	Distal upper limb amyotrophy (HP:0007149)	3.64489450
17	Diaphragmatic weakness (HP:0009113)	3.55968009
18	Potter facies (HP:0002009)	3.51335466
19	Facial shape deformation (HP:0011334)	3.51335466
20	Facial diplegia (HP:0001349)	3.49237350
21	Missing ribs (HP:0000921)	3.49224398
22	Metaphyseal cupping (HP:0003021)	3.48347500
23	Clumsiness (HP:0002312)	3.46020230
24	Premature skin wrinkling (HP:0100678)	3.34342253
25	Intention tremor (HP:0002080)	3.29670846
26	Cerebral inclusion bodies (HP:0100314)	3.29073362
27	Abnormal hemoglobin (HP:0011902)	3.27284349
28	Reticulocytopenia (HP:0001896)	3.19720691
29	Hyperglycinuria (HP:0003108)	3.16105779
30	Hyperphosphatemia (HP:0002905)	2.97539246
31	Nonprogressive disorder (HP:0003680)	2.90994690
32	Hyperglycinemia (HP:0002154)	2.90802839
33	Abnormality of glycine metabolism (HP:0010895)	2.87708541
34	Abnormality of serine family amino acid metabolism (HP:0010894)	2.87708541
35	Myocardial infarction (HP:0001658)	2.87334071
36	Vascular calcification (HP:0004934)	2.84116626
37	Abnormality of the calcaneus (HP:0008364)	2.75832174
38	Cardiovascular calcification (HP:0011915)	2.65538222
39	Hemiplegia (HP:0002301)	2.59414140
40	Abnormality of the musculature of the hand (HP:0001421)	2.57787330
41	Ankle clonus (HP:0011448)	2.55803297
42	Myopathic facies (HP:0002058)	2.50778682
43	Agitation (HP:0000713)	2.50420775
44	Infantile muscular hypotonia (HP:0008947)	2.48994098
45	Dysostosis multiplex (HP:0000943)	2.46578881
46	Anhidrosis (HP:0000970)	2.42060509
47	Cortical dysplasia (HP:0002539)	2.40041261
48	Oligomenorrhea (HP:0000876)	2.36707880
49	Hypoventilation (HP:0002791)	2.30535476
50	Acanthosis nigricans (HP:0000956)	2.26832606
51	Tubulointerstitial fibrosis (HP:0005576)	2.22981659
52	Concave nail (HP:0001598)	2.19373127
53	Skin nodule (HP:0200036)	2.17986010
54	Abnormality of the vocal cords (HP:0008777)	2.16343843
55	Hypophosphatemic rickets (HP:0004912)	2.16264456
56	Spondylolisthesis (HP:0003302)	2.16020343
57	Abnormality of macular pigmentation (HP:0008002)	2.14456655
58	Mutism (HP:0002300)	2.08341001
59	Parakeratosis (HP:0001036)	2.07188867
60	Hypertriglyceridemia (HP:0002155)	2.02539379
61	Hypotrichosis (HP:0001006)	2.02250043
62	Deep venous thrombosis (HP:0002625)	1.93764440
63	Restlessness (HP:0000711)	1.90205990
64	Thin ribs (HP:0000883)	1.88929595
65	Supranuclear gaze palsy (HP:0000605)	1.88165613
66	Duplicated collecting system (HP:0000081)	1.85368681
67	Pseudobulbar signs (HP:0002200)	1.85332468
68	Ketoacidosis (HP:0001993)	1.84714012
69	Abnormality of the dental root (HP:0006486)	1.83770195
70	Taurodontia (HP:0000679)	1.83770195
71	Abnormality of permanent molar morphology (HP:0011071)	1.83770195
72	Subcapsular cataract (HP:0000523)	1.81716096
73	Central scotoma (HP:0000603)	1.80670482
74	Focal segmental glomerulosclerosis (HP:0000097)	1.78014085
75	Depressed nasal ridge (HP:0000457)	1.77431253
76	Aplasia involving bones of the upper limbs (HP:0009823)	1.75527083
77	Aplasia of the phalanges of the hand (HP:0009802)	1.75527083
78	Aplasia involving bones of the extremities (HP:0009825)	1.75527083
79	Soft skin (HP:0000977)	1.75219582
80	Ectopia lentis (HP:0001083)	1.75083408
81	Abnormality of molar morphology (HP:0011070)	1.74236662
82	Abnormality of molar (HP:0011077)	1.74236662
83	Hypoplastic nipples (HP:0002557)	1.72971065
84	Oligodontia (HP:0000677)	1.72778436
85	Abnormality of the lumbar spine (HP:0100712)	1.71624578
86	Xanthomatosis (HP:0000991)	1.70906988
87	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.70600002
88	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.70591126
89	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.70591126
90	Myokymia (HP:0002411)	1.69816152
91	Glomerulosclerosis (HP:0000096)	1.69391381
92	Growth hormone excess (HP:0000845)	1.66987314
93	Lip pit (HP:0100267)	1.66609287
94	Right ventricular cardiomyopathy (HP:0011663)	1.62932911
95	Tongue fasciculations (HP:0001308)	1.58632341
96	Abnormality of the 4th metacarpal (HP:0010012)	1.57614511
97	Hemorrhage of the eye (HP:0011885)	1.57114539
98	Muscle fibrillation (HP:0010546)	1.56528341
99	Cervical subluxation (HP:0003308)	1.55799501
100	Hypoplasia of the uterus (HP:0000013)	1.54849696

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.55589401
2	EEF2K	3.51739806
3	MAP3K12	3.21969185
4	TAOK3	3.06426226
5	LATS1	2.80182076
6	MAP2K4	2.78977039
7	MAP3K4	2.45810676
8	SIK1	2.36940701
9	TRIB3	2.32927574
10	LATS2	2.14220984
11	LRRK2	2.12535458
12	MAP3K13	2.12126930
13	MAPKAPK5	2.05233819
14	FER	2.04558619
15	MAPKAPK3	1.98937290
16	MAP3K11	1.76501363
17	LMTK2	1.74473142
18	TRPM7	1.72888111
19	RIPK4	1.64031933
20	BMX	1.63415343
21	KSR2	1.60988005
22	STK24	1.54069341
23	RIPK1	1.52759108
24	MAP3K6	1.45932731
25	MST4	1.45103896
26	PKN2	1.34712120
27	PIK3CA	1.30699096
28	ERBB3	1.23963168
29	TTN	1.20323691
30	EPHB1	1.16263488
31	MARK2	1.16224925
32	PAK3	1.15396692
33	MST1R	1.14266350
34	YES1	1.13497394
35	NTRK3	1.13286404
36	MYLK	1.12975202
37	PAK6	1.11195970
38	ILK	1.08920060
39	WNK1	1.08302681
40	ERN1	1.08023738
41	RET	1.07244368
42	NTRK2	1.03840318
43	BCKDK	1.03342058
44	IRAK2	1.01376692
45	MAP3K9	0.99227633
46	PTK2	0.97658861
47	ERBB4	0.97265732
48	TTK	0.97157712
49	INSRR	0.97134550
50	MET	0.97079430
51	STK38L	0.94203902
52	NTRK1	0.86081587
53	RPS6KB2	0.84745154
54	PRKD3	0.83783585
55	MAP3K7	0.80957182
56	EPHB2	0.79717245
57	MAP3K1	0.76239712
58	MAP2K7	0.74049587
59	STK38	0.73863958
60	PAK2	0.70125007
61	TYK2	0.68949143
62	CAMK1D	0.67643736
63	MAPK12	0.65995336
64	TIE1	0.65588925
65	EGFR	0.64987025
66	DDR2	0.64574646
67	MOS	0.63993146
68	STK10	0.63863320
69	WNK3	0.63776293
70	PRKCH	0.62984068
71	CAMK1G	0.62068572
72	CSK	0.60568102
73	BMPR2	0.60162149
74	JAK2	0.59185214
75	PDPK1	0.56009702
76	PDK1	0.54011908
77	PDK3	0.52612061
78	PDK4	0.52612061
79	MAPK4	0.52441433
80	STK3	0.51511804
81	PDK2	0.50026208
82	PDGFRA	0.49296504
83	SRC	0.49172719
84	FRK	0.42822251
85	SGK1	0.42091249
86	ERBB2	0.42070547
87	MAPK13	0.41974874
88	UHMK1	0.40877677
89	INSR	0.40406949
90	PTK6	0.40389738
91	MAPK11	0.39460887
92	FYN	0.37584785
93	FGFR2	0.36921155
94	ABL2	0.36820734
95	ROCK1	0.33267403
96	IGF1R	0.33018560
97	PHKG1	0.31724502
98	PHKG2	0.31724502
99	PTK2B	0.30368408
100	PRKCZ	0.29905245

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.75666152
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.99739550
3	ABC transporters_Homo sapiens_hsa02010	2.81050793
4	Sulfur metabolism_Homo sapiens_hsa00920	2.78856702
5	PPAR signaling pathway_Homo sapiens_hsa03320	2.74689511
6	Phenylalanine metabolism_Homo sapiens_hsa00360	2.68991735
7	Fatty acid degradation_Homo sapiens_hsa00071	2.56581567
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.43103412
9	Other glycan degradation_Homo sapiens_hsa00511	2.38219858
10	Tyrosine metabolism_Homo sapiens_hsa00350	2.34802224
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.28711852
12	Fatty acid metabolism_Homo sapiens_hsa01212	2.26013000
13	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.23709677
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.18803163
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.03825635
16	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.03266932
17	beta-Alanine metabolism_Homo sapiens_hsa00410	1.95895794
18	Glycerolipid metabolism_Homo sapiens_hsa00561	1.94432824
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.89392500
20	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.78346354
21	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.74861069
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.71202119
23	Renin secretion_Homo sapiens_hsa04924	1.59077279
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.53204086
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.52906616
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.48146505
27	Complement and coagulation cascades_Homo sapiens_hsa04610	1.37902270
28	Salivary secretion_Homo sapiens_hsa04970	1.35798183
29	Prion diseases_Homo sapiens_hsa05020	1.24933240
30	Fat digestion and absorption_Homo sapiens_hsa04975	1.24112984
31	Propanoate metabolism_Homo sapiens_hsa00640	1.16904844
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.14895604
33	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.08644808
34	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.04186409
35	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98540702
36	Lysosome_Homo sapiens_hsa04142	0.91084651
37	Histidine metabolism_Homo sapiens_hsa00340	0.90558596
38	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.90103700
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.89216975
40	Carbon metabolism_Homo sapiens_hsa01200	0.86781271
41	Butanoate metabolism_Homo sapiens_hsa00650	0.85381023
42	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.82213732
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.82075587
44	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.81139189
45	Pyruvate metabolism_Homo sapiens_hsa00620	0.81012066
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76341910
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74216805
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.71641653
49	Peroxisome_Homo sapiens_hsa04146	0.70897319
50	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.65450673
51	GnRH signaling pathway_Homo sapiens_hsa04912	0.65171004
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.63831748
53	Pancreatic secretion_Homo sapiens_hsa04972	0.61988252
54	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.61582587
55	ECM-receptor interaction_Homo sapiens_hsa04512	0.61451200
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60727944
57	cAMP signaling pathway_Homo sapiens_hsa04024	0.59017880
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57314474
59	AMPK signaling pathway_Homo sapiens_hsa04152	0.56970935
60	Insulin resistance_Homo sapiens_hsa04931	0.56369385
61	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.56080713
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.55717908
63	Bile secretion_Homo sapiens_hsa04976	0.54784697
64	Estrogen signaling pathway_Homo sapiens_hsa04915	0.54177438
65	Gastric acid secretion_Homo sapiens_hsa04971	0.52919635
66	Ribosome_Homo sapiens_hsa03010	0.52245951
67	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.51774095
68	Protein digestion and absorption_Homo sapiens_hsa04974	0.50014635
69	Glutathione metabolism_Homo sapiens_hsa00480	0.49382809
70	Cocaine addiction_Homo sapiens_hsa05030	0.49031371
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47887122
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46905228
73	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.44463333
74	Choline metabolism in cancer_Homo sapiens_hsa05231	0.44370547
75	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.43135868
76	Type II diabetes mellitus_Homo sapiens_hsa04930	0.41208438
77	Sphingolipid metabolism_Homo sapiens_hsa00600	0.40804403
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40275352
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39330470
80	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39163438
81	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.38525542
82	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.38018875
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.37917029
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33686816
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.32287817
86	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32128387
87	Fatty acid elongation_Homo sapiens_hsa00062	0.31319241
88	Adherens junction_Homo sapiens_hsa04520	0.30945109
89	Caffeine metabolism_Homo sapiens_hsa00232	0.28231478
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.27118013
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26305205
92	Circadian entrainment_Homo sapiens_hsa04713	0.26209002
93	GABAergic synapse_Homo sapiens_hsa04727	0.24802802
94	Retinol metabolism_Homo sapiens_hsa00830	0.24559708
95	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.23620032
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.23211064
97	Focal adhesion_Homo sapiens_hsa04510	0.22710024
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.22594439
99	Long-term depression_Homo sapiens_hsa04730	0.22081886
100	VEGF signaling pathway_Homo sapiens_hsa04370	0.22016361

PATE3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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