PATE4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cysteine metabolic process (GO:0006534)9.46288275
2sulfur amino acid catabolic process (GO:0000098)8.17156867
3mannose metabolic process (GO:0006013)7.63344151
4ectodermal placode formation (GO:0060788)7.35180180
5N-glycan processing (GO:0006491)6.64716529
6creatine metabolic process (GO:0006600)6.53431574
7COPI coating of Golgi vesicle (GO:0048205)6.50562191
8Golgi transport vesicle coating (GO:0048200)6.50562191
9anterior/posterior axis specification, embryo (GO:0008595)5.84606171
10endocardial cushion morphogenesis (GO:0003203)5.68950918
11fucose catabolic process (GO:0019317)5.67259800
12L-fucose metabolic process (GO:0042354)5.67259800
13L-fucose catabolic process (GO:0042355)5.67259800
14apoptotic DNA fragmentation (GO:0006309)5.25516849
15valine metabolic process (GO:0006573)5.16963005
16negative regulation of erythrocyte differentiation (GO:0045647)4.97707865
17positive regulation of natural killer cell differentiation (GO:0032825)4.82608751
18mesenchyme morphogenesis (GO:0072132)4.73450084
19hypotonic response (GO:0006971)4.49532177
20galactose catabolic process (GO:0019388)4.47828822
21sodium-independent organic anion transport (GO:0043252)4.44796712
22branching involved in prostate gland morphogenesis (GO:0060442)4.30647625
23vitamin transmembrane transport (GO:0035461)4.27705624
24endocrine hormone secretion (GO:0060986)4.27676408
25oxaloacetate metabolic process (GO:0006107)4.26413906
26activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.24129169
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.23313924
28detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.21056873
29indolalkylamine metabolic process (GO:0006586)4.13989709
30glycoprotein catabolic process (GO:0006516)4.09937921
31serine family amino acid catabolic process (GO:0009071)4.06685046
32DNA deamination (GO:0045006)4.04546468
33positive regulation of nuclease activity (GO:0032075)4.04455214
34tryptophan catabolic process (GO:0006569)3.97538594
35indole-containing compound catabolic process (GO:0042436)3.97538594
36indolalkylamine catabolic process (GO:0046218)3.97538594
37positive regulation of growth hormone secretion (GO:0060124)3.96112057
38positive regulation of megakaryocyte differentiation (GO:0045654)3.94583547
39muscle cell fate commitment (GO:0042693)3.91901412
40response to pheromone (GO:0019236)3.91702851
41potassium ion homeostasis (GO:0055075)3.89813670
42protein polyglutamylation (GO:0018095)3.89374031
43mammary gland development (GO:0030879)3.89064806
44cellular modified amino acid catabolic process (GO:0042219)3.86174141
45embryonic camera-type eye morphogenesis (GO:0048596)3.85404334
46regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.74468497
47regulation of clathrin-mediated endocytosis (GO:2000369)3.73575419
48axoneme assembly (GO:0035082)3.70547673
49epithelial cell differentiation involved in prostate gland development (GO:0060742)3.70240375
50fucose metabolic process (GO:0006004)3.69738517
51behavioral response to nicotine (GO:0035095)3.68315810
52mitochondrion distribution (GO:0048311)3.66581604
53negative regulation of sodium ion transport (GO:0010766)3.66289323
54regulation of nuclease activity (GO:0032069)3.62527101
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59984774
56ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.58276660
57detection of light stimulus involved in sensory perception (GO:0050962)3.57306285
58detection of light stimulus involved in visual perception (GO:0050908)3.57306285
59photoreceptor cell maintenance (GO:0045494)3.57116307
60activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.55419427
61platelet dense granule organization (GO:0060155)3.54959454
62neural tube formation (GO:0001841)3.54056059
63mammary gland epithelial cell differentiation (GO:0060644)3.54025299
64signal peptide processing (GO:0006465)3.53797559
65cellular senescence (GO:0090398)3.53788927
66hormone catabolic process (GO:0042447)3.52123030
67peptide catabolic process (GO:0043171)3.50458758
68outflow tract septum morphogenesis (GO:0003148)3.49945743
69COPII vesicle coating (GO:0048208)3.49101854
70endoplasmic reticulum unfolded protein response (GO:0030968)3.48088321
71piRNA metabolic process (GO:0034587)3.45210668
72reflex (GO:0060004)3.41327727
73cellular ketone body metabolic process (GO:0046950)3.39612314
74vesicle coating (GO:0006901)3.38475660
75establishment of protein localization to Golgi (GO:0072600)3.38328317
76pyrimidine-containing compound transmembrane transport (GO:0072531)3.37948354
77forebrain morphogenesis (GO:0048853)3.37404400
78cilium or flagellum-dependent cell motility (GO:0001539)3.37180315
79regulation of growth hormone secretion (GO:0060123)3.34472028
80cellular response to unfolded protein (GO:0034620)3.33958260
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.33678836
82kynurenine metabolic process (GO:0070189)3.33448464
83positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.33105603
84mucosal-associated lymphoid tissue development (GO:0048537)3.30603009
85Peyers patch development (GO:0048541)3.30603009
86prostate gland epithelium morphogenesis (GO:0060740)3.28775788
87tryptophan metabolic process (GO:0006568)3.28133083
88gamma-aminobutyric acid transport (GO:0015812)3.27311728
89ER-nucleus signaling pathway (GO:0006984)3.26435379
902-oxoglutarate metabolic process (GO:0006103)3.21959725
91protein N-linked glycosylation via asparagine (GO:0018279)3.21581740
92pathway-restricted SMAD protein phosphorylation (GO:0060389)3.21472327
93regulation of cilium movement (GO:0003352)3.21229366
94gland morphogenesis (GO:0022612)3.20876999
95peptidyl-asparagine modification (GO:0018196)3.20073989
96UDP-N-acetylglucosamine metabolic process (GO:0006047)3.18014533
97prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.17762870
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.17555739
99positive regulation of gamma-delta T cell activation (GO:0046645)3.17385485
100ketone body metabolic process (GO:1902224)3.16745327
101protein K11-linked deubiquitination (GO:0035871)3.16640652
102DNA double-strand break processing (GO:0000729)3.16333890
103respiratory chain complex IV assembly (GO:0008535)3.15728223
104regulation of hippo signaling (GO:0035330)3.15263177
105mannosylation (GO:0097502)3.13754608
106regulation of heart morphogenesis (GO:2000826)3.13544126
107ectoderm development (GO:0007398)3.11786578
108intestinal epithelial cell development (GO:0060576)3.10614083
109sulfur compound catabolic process (GO:0044273)3.10569628
110sequestering of metal ion (GO:0051238)3.09867118
111morphogenesis of an epithelial fold (GO:0060571)3.06716328
112negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.05910136
113cellular biogenic amine catabolic process (GO:0042402)3.05863859
114amine catabolic process (GO:0009310)3.05863859
115response to endoplasmic reticulum stress (GO:0034976)3.05778953
116male genitalia development (GO:0030539)3.05615572
117intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.04531416
118regulation of gamma-delta T cell differentiation (GO:0045586)3.04266399
119cellular response to topologically incorrect protein (GO:0035967)3.03500149
120adaptation of signaling pathway (GO:0023058)3.02071793
121cytochrome complex assembly (GO:0017004)3.01643668
122behavioral response to ethanol (GO:0048149)3.01483190
123water-soluble vitamin biosynthetic process (GO:0042364)3.00191646
124tachykinin receptor signaling pathway (GO:0007217)3.00027598
125retinal cone cell development (GO:0046549)2.98125405
126mitochondrial calcium ion transport (GO:0006851)2.97943635
127protein retention in ER lumen (GO:0006621)2.97748978
128cornea development in camera-type eye (GO:0061303)2.95899120
129pyrimidine nucleobase catabolic process (GO:0006208)2.95185080
130indole-containing compound metabolic process (GO:0042430)2.94518302
131protein targeting to Golgi (GO:0000042)2.93944923
132epithelial cilium movement (GO:0003351)2.93450902
133cilium morphogenesis (GO:0060271)2.92350728
134protein N-linked glycosylation (GO:0006487)2.90906200
135insulin-like growth factor receptor signaling pathway (GO:0048009)2.90670833
136regulation of natural killer cell differentiation (GO:0032823)2.90523330
137regulation of translation, ncRNA-mediated (GO:0045974)2.88612158
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88612158
139negative regulation of translation, ncRNA-mediated (GO:0040033)2.88612158
140nonmotile primary cilium assembly (GO:0035058)2.85112595
141transmission of nerve impulse (GO:0019226)2.84855073
142negative regulation of telomere maintenance (GO:0032205)2.83331188
143nerve growth factor signaling pathway (GO:0038180)2.81908839
144branched-chain amino acid metabolic process (GO:0009081)2.79670886
145nucleobase catabolic process (GO:0046113)2.79519209
146hexose catabolic process (GO:0019320)2.78986145
147cilium organization (GO:0044782)2.78461543
148definitive hemopoiesis (GO:0060216)2.78321663
149regulation of protein glycosylation (GO:0060049)2.78263481
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77559997
151natural killer cell differentiation (GO:0001779)2.74727327
152succinate metabolic process (GO:0006105)2.74411413
153DNA methylation involved in gamete generation (GO:0043046)2.74253783
154cilium assembly (GO:0042384)2.73679116
155regulation of sarcomere organization (GO:0060297)2.73473611
156negative regulation of GTPase activity (GO:0034260)2.72666675
157negative regulation of GTP catabolic process (GO:0033125)2.72666675
158protein localization to cilium (GO:0061512)2.72236812
159response to unfolded protein (GO:0006986)2.72079910
160auditory receptor cell stereocilium organization (GO:0060088)2.71730085
161detection of mechanical stimulus involved in sensory perception (GO:0050974)2.67721705
162neuronal action potential propagation (GO:0019227)2.67587422
163cilium movement (GO:0003341)2.65180707
164protein-cofactor linkage (GO:0018065)2.65082729
165protein complex biogenesis (GO:0070271)2.64702626
166sulfation (GO:0051923)2.63873443
167glycosphingolipid biosynthetic process (GO:0006688)2.63341018
168thyroid hormone metabolic process (GO:0042403)2.63204702
169dopamine transport (GO:0015872)2.62309330
170C4-dicarboxylate transport (GO:0015740)2.62002849
171righting reflex (GO:0060013)2.61872925
172benzene-containing compound metabolic process (GO:0042537)2.58978374
173negative regulation of mast cell activation (GO:0033004)2.58378392
174regulation of neurotransmitter uptake (GO:0051580)2.55789807
175regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.55298891
176inner ear receptor stereocilium organization (GO:0060122)2.55084295
177L-methionine salvage (GO:0071267)2.54442760
178L-methionine biosynthetic process (GO:0071265)2.54442760
179amino acid salvage (GO:0043102)2.54442760
180neuronal action potential (GO:0019228)2.54189780
181negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54152469
182intraciliary transport (GO:0042073)2.51444501
183anterograde synaptic vesicle transport (GO:0048490)2.49538192
184negative regulation of systemic arterial blood pressure (GO:0003085)2.48315597
185drug catabolic process (GO:0042737)2.48268674
186male meiosis (GO:0007140)2.48254432
187retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47966223
188acrosome assembly (GO:0001675)2.47597452
189preassembly of GPI anchor in ER membrane (GO:0016254)2.45683342
190rhodopsin mediated signaling pathway (GO:0016056)2.45499794
191protein prenylation (GO:0018342)2.44095439
192prenylation (GO:0097354)2.44095439
193embryonic epithelial tube formation (GO:0001838)2.43889181
194oxidative demethylation (GO:0070989)2.42883314
195regulation of telomere maintenance (GO:0032204)2.42817997
196negative regulation of calcium ion transport into cytosol (GO:0010523)2.40897999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.69562734
2ZNF263_19887448_ChIP-Seq_K562_Human4.20186239
3GBX2_23144817_ChIP-Seq_PC3_Human3.57194714
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.41031451
5VDR_22108803_ChIP-Seq_LS180_Human3.14518011
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.95476358
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87486713
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80922792
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79905719
10IGF1R_20145208_ChIP-Seq_DFB_Human2.74851519
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.71109401
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.67369563
13EZH2_22144423_ChIP-Seq_EOC_Human2.66129735
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61721229
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41279844
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.30202574
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.29736195
18TAF15_26573619_Chip-Seq_HEK293_Human2.28815888
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25096423
20P300_19829295_ChIP-Seq_ESCs_Human2.21804325
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20615219
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.20148655
23SOX2_20726797_ChIP-Seq_SW620_Human2.16567947
24FUS_26573619_Chip-Seq_HEK293_Human2.15148929
25AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.14789977
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05900074
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.00125502
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.99943658
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98443521
30ER_23166858_ChIP-Seq_MCF-7_Human1.93433356
31FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.91843999
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91727427
33EWS_26573619_Chip-Seq_HEK293_Human1.91221662
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91191387
35CLOCK_20551151_ChIP-Seq_293T_Human1.87949354
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.87535728
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.85809481
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84387875
39SMAD4_21799915_ChIP-Seq_A2780_Human1.84277567
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83055213
41GATA6_25053715_ChIP-Seq_YYC3_Human1.81224524
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78777517
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77664699
44STAT3_23295773_ChIP-Seq_U87_Human1.77596739
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.76203873
46GATA4_25053715_ChIP-Seq_YYC3_Human1.73949622
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73625467
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.73230626
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.71911739
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.71402510
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71371446
52AHR_22903824_ChIP-Seq_MCF-7_Human1.70622158
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.68674644
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67024769
55CBP_20019798_ChIP-Seq_JUKART_Human1.67024769
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65606891
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.64429424
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63513917
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63312838
60BCAT_22108803_ChIP-Seq_LS180_Human1.60141348
61TCF4_23295773_ChIP-Seq_U87_Human1.59497041
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58487475
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.58130589
64RACK7_27058665_Chip-Seq_MCF-7_Human1.56976040
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54847666
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54497224
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54273445
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52499741
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51851318
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51599797
71CHD1_26751641_Chip-Seq_LNCaP_Human1.51111257
72AR_25329375_ChIP-Seq_VCAP_Human1.50203117
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50002086
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48942048
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48649611
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48422558
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.48096217
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.46796306
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.46796306
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.44290006
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43775434
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.43323930
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41611478
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41514023
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41514023
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41514023
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41470184
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41463917
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40689694
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40621073
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.39560528
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39352065
93SOX2_19829295_ChIP-Seq_ESCs_Human1.39141015
94NANOG_19829295_ChIP-Seq_ESCs_Human1.39141015
95TP53_22573176_ChIP-Seq_HFKS_Human1.38347080
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38011516
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37943637
98EP300_21415370_ChIP-Seq_HL-1_Mouse1.37413035
99RXR_22158963_ChIP-Seq_LIVER_Mouse1.37367539
100TCF4_22108803_ChIP-Seq_LS180_Human1.36730658
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.36418964
102PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35492624
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35129835
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35129835
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34087332
106ZNF274_21170338_ChIP-Seq_K562_Hela1.33693857
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31787893
108RUNX2_22187159_ChIP-Seq_PCA_Human1.30988941
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30599400
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30542264
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30468065
112IRF1_19129219_ChIP-ChIP_H3396_Human1.30099941
113TRIM28_21343339_ChIP-Seq_HEK293_Human1.28885010
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28879943
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.28855979
116PKCTHETA_26484144_Chip-Seq_BREAST_Human1.28300142
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28018390
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.27773615
119SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27703262
120FOXA1_25552417_ChIP-Seq_VCAP_Human1.27161688
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.25825638
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25051929
123GATA3_24758297_ChIP-Seq_MCF-7_Human1.23856311
124TP63_17297297_ChIP-ChIP_HaCaT_Human1.22859891
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22533276
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21332419
127* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20781430
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.20502205
129P53_22387025_ChIP-Seq_ESCs_Mouse1.20481533
130REST_21632747_ChIP-Seq_MESCs_Mouse1.18837589
131STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18694968
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.18596350
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18310579
134CDX2_22108803_ChIP-Seq_LS180_Human1.17675421
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17436527
136RNF2_27304074_Chip-Seq_NSC_Mouse1.14568875
137CREB1_26743006_Chip-Seq_LNCaP_Human1.14520751
138NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14016357
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14016357
140STAT3_18555785_Chip-Seq_ESCs_Mouse1.13107559
141FLI1_21867929_ChIP-Seq_TH2_Mouse1.12853136
142E2F1_18555785_Chip-Seq_ESCs_Mouse1.10932817
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09241203
144FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08687309
145FOXA1_25329375_ChIP-Seq_VCAP_Human1.08687309
146GATA1_22025678_ChIP-Seq_K562_Human1.07561585
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06014135
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05976410
149ISL1_27105846_Chip-Seq_CPCs_Mouse1.05873087
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04983299
151ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04695886
152OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04404143
153FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03855412
154RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03805780
155TBX20_22328084_ChIP-Seq_HEART_Mouse1.03238681
156TBX20_22080862_ChIP-Seq_HEART_Mouse1.03238681
157CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03173985
158CBX2_27304074_Chip-Seq_ESCs_Mouse1.03168871
159SOX2_21211035_ChIP-Seq_LN229_Gbm1.03040902
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02920290
161KDM2B_26808549_Chip-Seq_K562_Human1.02699689
162NCOR_22424771_ChIP-Seq_293T_Human1.02463553
163BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02362584
164SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02006892
165PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01958841
166ATF3_27146783_Chip-Seq_COLON_Human1.01257437
167AR_20517297_ChIP-Seq_VCAP_Human1.00914585
168GATA2_21666600_ChIP-Seq_HMVEC_Human1.00786305
169ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00703020
170P300_18555785_Chip-Seq_ESCs_Mouse1.00439374
171CMYC_18555785_Chip-Seq_ESCs_Mouse1.00340517
172SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99629185
173STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99573032
174CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99558873
175FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99325851
176BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98858204
177TP53_16413492_ChIP-PET_HCT116_Human0.98684921
178RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97598894
179KDM2B_26808549_Chip-Seq_REH_Human0.97020299
180ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96955905
181RXR_22108803_ChIP-Seq_LS180_Human0.96893922
182FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95524538
183P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93798649
184GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93147662
185GATA2_19941826_ChIP-Seq_K562_Human0.92657210
186TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92264830
187RING1B_27294783_Chip-Seq_NPCs_Mouse0.91788178
188KLF5_25053715_ChIP-Seq_YYC3_Human0.91462799
189TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91147440
190ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90203387
191CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90188550
192PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89146676
193YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88912666
194FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88484642
195DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87922508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology5.06842823
2MP0010234_abnormal_vibrissa_follicle4.51176013
3MP0002090_abnormal_vision3.46188727
4MP0010386_abnormal_urinary_bladder3.32397383
5MP0002009_preneoplasia3.27663943
6MP0008877_abnormal_DNA_methylation2.99498168
7MP0004264_abnormal_extraembryonic_tissu2.95811969
8MP0003195_calcinosis2.92143940
9MP0003300_gastrointestinal_ulcer2.87819281
10MP0003183_abnormal_peptide_metabolism2.79576550
11MP0002166_altered_tumor_susceptibility2.78172209
12MP0005058_abnormal_lysosome_morphology2.76706358
13MP0004858_abnormal_nervous_system2.71230021
14MP0000569_abnormal_digit_pigmentation2.70122289
15MP0000516_abnormal_urinary_system2.62000881
16MP0005367_renal/urinary_system_phenotyp2.62000881
17MP0005310_abnormal_salivary_gland2.61203487
18MP0001968_abnormal_touch/_nociception2.50117130
19MP0001765_abnormal_ion_homeostasis2.42428790
20MP0005551_abnormal_eye_electrophysiolog2.42173477
21MP0003705_abnormal_hypodermis_morpholog2.31437859
22MP0002736_abnormal_nociception_after2.29528336
23MP0001756_abnormal_urination2.27956408
24MP0009046_muscle_twitch2.25989440
25MP0000534_abnormal_ureter_morphology2.20976622
26MP0003315_abnormal_perineum_morphology2.20577555
27MP0002102_abnormal_ear_morphology2.18478110
28MP0000538_abnormal_urinary_bladder2.09525093
29MP0001501_abnormal_sleep_pattern2.07002776
30MP0000372_irregular_coat_pigmentation2.06061302
31MP0001984_abnormal_olfaction2.05796695
32MP0003880_abnormal_central_pattern1.98790321
33MP0006072_abnormal_retinal_apoptosis1.98731809
34MP0005253_abnormal_eye_physiology1.98460817
35MP0003787_abnormal_imprinting1.95324790
36MP0006276_abnormal_autonomic_nervous1.95119671
37MP0005220_abnormal_exocrine_pancreas1.87228723
38MP0001873_stomach_inflammation1.84710113
39MP0002006_tumorigenesis1.83427774
40MP0010352_gastrointestinal_tract_polyps1.82947901
41MP0009780_abnormal_chondrocyte_physiolo1.79378906
42MP0000613_abnormal_salivary_gland1.79159573
43MP0002638_abnormal_pupillary_reflex1.79040430
44MP0009745_abnormal_behavioral_response1.74761354
45MP0008438_abnormal_cutaneous_collagen1.74153549
46MP0005645_abnormal_hypothalamus_physiol1.73058123
47MP0000462_abnormal_digestive_system1.71405222
48MP0005636_abnormal_mineral_homeostasis1.70942256
49MP0003136_yellow_coat_color1.70426261
50MP0003646_muscle_fatigue1.70349305
51MP0001666_abnormal_nutrient_absorption1.69424000
52MP0002653_abnormal_ependyma_morphology1.67233871
53MP0000427_abnormal_hair_cycle1.67169829
54MP0003656_abnormal_erythrocyte_physiolo1.67124693
55MP0000627_abnormal_mammary_gland1.64776177
56MP0002163_abnormal_gland_morphology1.63927284
57MP0001986_abnormal_taste_sensitivity1.62642888
58MP0008872_abnormal_physiological_respon1.62365594
59MP0004043_abnormal_pH_regulation1.60443481
60MP0004142_abnormal_muscle_tone1.59789139
61MP0002272_abnormal_nervous_system1.57026256
62MP0001881_abnormal_mammary_gland1.55453307
63MP0001486_abnormal_startle_reflex1.55220253
64MP0001958_emphysema1.52378091
65MP0000631_abnormal_neuroendocrine_gland1.46478658
66MP0002234_abnormal_pharynx_morphology1.45711880
67MP0005379_endocrine/exocrine_gland_phen1.45341772
68MP0001299_abnormal_eye_distance/1.41518476
69MP0001346_abnormal_lacrimal_gland1.40459647
70MP0004036_abnormal_muscle_relaxation1.38183930
71MP0001529_abnormal_vocalization1.37803996
72MP0002928_abnormal_bile_duct1.37280256
73MP0006292_abnormal_olfactory_placode1.34581120
74MP0002735_abnormal_chemical_nociception1.32954041
75MP0002938_white_spotting1.32800488
76MP0002876_abnormal_thyroid_physiology1.31764430
77MP0001485_abnormal_pinna_reflex1.29147280
78MP0004924_abnormal_behavior1.24554934
79MP0005386_behavior/neurological_phenoty1.24554934
80MP0003936_abnormal_reproductive_system1.22449129
81MP0008057_abnormal_DNA_replication1.22368398
82MP0002572_abnormal_emotion/affect_behav1.22015967
83MP0005174_abnormal_tail_pigmentation1.21789556
84MP0000750_abnormal_muscle_regeneration1.21443736
85MP0008875_abnormal_xenobiotic_pharmacok1.21432002
86MP0009764_decreased_sensitivity_to1.20568677
87MP0009643_abnormal_urine_homeostasis1.18872573
88MP0000751_myopathy1.18718079
89MP0002557_abnormal_social/conspecific_i1.18364021
90MP0006054_spinal_hemorrhage1.17294993
91MP0000579_abnormal_nail_morphology1.17156490
92MP0005187_abnormal_penis_morphology1.15989842
93MP0001764_abnormal_homeostasis1.15150010
94MP0005646_abnormal_pituitary_gland1.15144396
95MP0002067_abnormal_sensory_capabilities1.14804941
96MP0005084_abnormal_gallbladder_morpholo1.13986049
97MP0003566_abnormal_cell_adhesion1.13029043
98MP0005085_abnormal_gallbladder_physiolo1.13011506
99MP0004145_abnormal_muscle_electrophysio1.12613781
100MP0001905_abnormal_dopamine_level1.11178406
101MP0008995_early_reproductive_senescence1.10857211
102MP0002060_abnormal_skin_morphology1.10065799
103MP0005075_abnormal_melanosome_morpholog1.10009581
104MP0002751_abnormal_autonomic_nervous1.09672552
105MP0005410_abnormal_fertilization1.08946877
106MP0002733_abnormal_thermal_nociception1.08685992
107MP0002896_abnormal_bone_mineralization1.08348617
108MP0002095_abnormal_skin_pigmentation1.08228814
109MP0002064_seizures1.07923932
110MP0000383_abnormal_hair_follicle1.07895771
111MP0001970_abnormal_pain_threshold1.07492474
112MP0004133_heterotaxia1.06964526
113MP0002909_abnormal_adrenal_gland1.04688980
114MP0005330_cardiomyopathy1.04189891
115MP0003635_abnormal_synaptic_transmissio1.04017291
116MP0001664_abnormal_digestion1.02890301
117MP0003252_abnormal_bile_duct1.01766327
118MP0005319_abnormal_enzyme/_coenzyme1.01635695
119MP0003698_abnormal_male_reproductive1.00796174
120MP0004147_increased_porphyrin_level1.00097319
121MP0002139_abnormal_hepatobiliary_system1.00017915
122MP0010678_abnormal_skin_adnexa0.98482658
123MP0005623_abnormal_meninges_morphology0.98058713
124MP0005076_abnormal_cell_differentiation0.97914291
125MP0002136_abnormal_kidney_physiology0.97652448
126MP0000778_abnormal_nervous_system0.97063867
127MP0008058_abnormal_DNA_repair0.96774456
128MP0000647_abnormal_sebaceous_gland0.95316419
129MP0001944_abnormal_pancreas_morphology0.93785352
130MP0005670_abnormal_white_adipose0.93573562
131MP0005257_abnormal_intraocular_pressure0.92982273
132MP0003121_genomic_imprinting0.91865727
133MP0005195_abnormal_posterior_eye0.91604979
134MP0002295_abnormal_pulmonary_circulatio0.90724082
135MP0000566_synostosis0.90417810
136MP0002229_neurodegeneration0.90306009
137MP0003718_maternal_effect0.90122881
138MP0003045_fibrosis0.89973384
139MP0009384_cardiac_valve_regurgitation0.89966336
140MP0002063_abnormal_learning/memory/cond0.89841279
141MP0005332_abnormal_amino_acid0.89484185
142MP0002752_abnormal_somatic_nervous0.89453474
143MP0002089_abnormal_postnatal_growth/wei0.89208865
144MP0003866_abnormal_defecation0.88951355
145MP0002160_abnormal_reproductive_system0.87881898
146MP0000681_abnormal_thyroid_gland0.87824590
147MP0005389_reproductive_system_phenotype0.87025062
148MP0003942_abnormal_urinary_system0.85621914
149MP0005381_digestive/alimentary_phenotyp0.85144792
150MP0008789_abnormal_olfactory_epithelium0.84738417
151MP0005248_abnormal_Harderian_gland0.84611150
152MP0003937_abnormal_limbs/digits/tail_de0.84330151
153MP0000470_abnormal_stomach_morphology0.84264260
154MP0004130_abnormal_muscle_cell0.83340748
155MP0003011_delayed_dark_adaptation0.83280709
156MP0001929_abnormal_gametogenesis0.82560703
157MP0002693_abnormal_pancreas_physiology0.80649497
158MP0001963_abnormal_hearing_physiology0.80378591
159MP0005166_decreased_susceptibility_to0.78314166
160MP0002734_abnormal_mechanical_nocicepti0.77971438
161MP0000026_abnormal_inner_ear0.77161024
162MP0005647_abnormal_sex_gland0.77109295
163MP0004742_abnormal_vestibular_system0.76453105
164MP0004215_abnormal_myocardial_fiber0.75709819
165MP0005164_abnormal_response_to0.75570018
166MP0004885_abnormal_endolymph0.75320636
167MP0002168_other_aberrant_phenotype0.74829741
168MP0004272_abnormal_basement_membrane0.74707217
169MP0005275_abnormal_skin_tensile0.73985550
170MP0004947_skin_inflammation0.72843502
171MP0005193_abnormal_anterior_eye0.72241335
172MP0002115_abnormal_skeleton_extremities0.71379337
173MP0002837_dystrophic_cardiac_calcinosis0.70533551
174MP0009765_abnormal_xenobiotic_induced0.66942063
175MP0000371_diluted_coat_color0.64904561
176MP0002135_abnormal_kidney_morphology0.64867531
177MP0000762_abnormal_tongue_morphology0.60986594
178MP0000230_abnormal_systemic_arterial0.60873350
179MP0003091_abnormal_cell_migration0.58501447
180MP0004085_abnormal_heartbeat0.57336309
181MP0003638_abnormal_response/metabolism_0.56870114
182MP0003690_abnormal_glial_cell0.55555492
183MP0005620_abnormal_muscle_contractility0.55108726
184MP0003935_abnormal_craniofacial_develop0.54855839
185MP0009053_abnormal_anal_canal0.53938826
186MP0002109_abnormal_limb_morphology0.53781359
187MP0000477_abnormal_intestine_morphology0.53414628

Predicted human phenotypes

RankGene SetZ-score
1Shawl scrotum (HP:0000049)8.00931786
2Aortic aneurysm (HP:0004942)6.08752230
3Abnormality of the axillary hair (HP:0100134)5.77783589
4Abnormality of secondary sexual hair (HP:0009888)5.77783589
5Aortic dissection (HP:0002647)4.66249717
6Long toe (HP:0010511)4.47219470
7Sparse lateral eyebrow (HP:0005338)4.35908728
8Pancreatic cysts (HP:0001737)4.29704240
9Aplastic anemia (HP:0001915)4.23563642
10Hyperventilation (HP:0002883)4.15832315
11Aplasia of the musculature (HP:0100854)4.15771296
12Pancreatic fibrosis (HP:0100732)4.11973058
13Myopathic facies (HP:0002058)4.11761116
14Malnutrition (HP:0004395)3.97374749
15True hermaphroditism (HP:0010459)3.89032855
16Gaze-evoked nystagmus (HP:0000640)3.81725747
17Camptodactyly of toe (HP:0001836)3.75948936
18Abnormality of midbrain morphology (HP:0002418)3.69622435
19Molar tooth sign on MRI (HP:0002419)3.69622435
20Medial flaring of the eyebrow (HP:0010747)3.67146843
21Hypoplastic nipples (HP:0002557)3.65586160
22Nephronophthisis (HP:0000090)3.45761245
23Breast hypoplasia (HP:0003187)3.39637391
24Ileus (HP:0002595)3.37043342
25Agitation (HP:0000713)3.33822095
26Congenital stationary night blindness (HP:0007642)3.32837289
27Midline defect of the nose (HP:0004122)3.29547700
28Blepharitis (HP:0000498)3.26667274
29Abnormality of the renal medulla (HP:0100957)3.15779941
30Aplasia/Hypoplasia of the scapulae (HP:0006713)3.12765231
31Hypoplastic scapulae (HP:0000882)3.12765231
32Vacuolated lymphocytes (HP:0001922)3.12717833
33Anal stenosis (HP:0002025)3.12326458
34Short humerus (HP:0005792)3.11543621
35Testicular atrophy (HP:0000029)3.11055226
36Abnormality of the renal cortex (HP:0011035)3.04785008
37Infantile muscular hypotonia (HP:0008947)3.00776921
38Chronic hepatic failure (HP:0100626)2.98643298
39Absent speech (HP:0001344)2.98446095
40Gait imbalance (HP:0002141)2.96728898
41Absent hand (HP:0004050)2.96355684
42Attenuation of retinal blood vessels (HP:0007843)2.91996507
43Potter facies (HP:0002009)2.90241074
44Facial shape deformation (HP:0011334)2.90241074
45Type II lissencephaly (HP:0007260)2.88413647
46Congenital primary aphakia (HP:0007707)2.87463349
47Aneurysm (HP:0002617)2.86001332
48Abnormality of the intrinsic pathway (HP:0010989)2.84044228
49Rectal prolapse (HP:0002035)2.79710071
50Hematochezia (HP:0002573)2.79541434
51Progressive cerebellar ataxia (HP:0002073)2.79057974
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.76369009
53Hemiplegia (HP:0002301)2.76042608
54Aortic regurgitation (HP:0001659)2.75826060
55Gastrointestinal dysmotility (HP:0002579)2.74263098
56Hypothermia (HP:0002045)2.74044094
57Joint contractures involving the joints of the feet (HP:0100492)2.73370093
58Flexion contracture of toe (HP:0005830)2.73370093
59Short clavicles (HP:0000894)2.73064127
60Cystic liver disease (HP:0006706)2.71792369
61Right ventricular cardiomyopathy (HP:0011663)2.71188941
62Aplasia/hypoplasia of the humerus (HP:0006507)2.68093356
63Abnormality of oral frenula (HP:0000190)2.67629046
64Hypoplasia of the ulna (HP:0003022)2.65256531
65Nephrogenic diabetes insipidus (HP:0009806)2.64890753
66Abolished electroretinogram (ERG) (HP:0000550)2.63088670
67Renal cortical cysts (HP:0000803)2.60205252
68Tubulointerstitial nephritis (HP:0001970)2.58955166
69Genital tract atresia (HP:0001827)2.57604303
70Genetic anticipation (HP:0003743)2.55158036
71Broad-based gait (HP:0002136)2.53578764
72Febrile seizures (HP:0002373)2.51292877
73Hypoplasia of the pons (HP:0012110)2.50103226
74Aplasia/Hypoplasia of the clavicles (HP:0006710)2.42941632
75Ankyloglossia (HP:0010296)2.42355800
76Abnormal foot bone ossification (HP:0010675)2.42005765
77Inability to walk (HP:0002540)2.41157928
78Facial diplegia (HP:0001349)2.41151437
79Vaginal atresia (HP:0000148)2.39187762
80Aplasia involving bones of the upper limbs (HP:0009823)2.38988941
81Aplasia of the phalanges of the hand (HP:0009802)2.38988941
82Aplasia involving bones of the extremities (HP:0009825)2.38988941
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.36084493
84Cholecystitis (HP:0001082)2.35467162
85Abnormal gallbladder physiology (HP:0012438)2.35467162
86Ankle contracture (HP:0006466)2.33681129
87Cerebellar dysplasia (HP:0007033)2.32767322
88Abnormality of the 2nd finger (HP:0004100)2.30945269
89Hypoplastic labia majora (HP:0000059)2.30241411
90Congenital sensorineural hearing impairment (HP:0008527)2.28000369
91Intestinal atresia (HP:0011100)2.26607783
92Progressive inability to walk (HP:0002505)2.25990372
93Lissencephaly (HP:0001339)2.24842977
94Abnormality of the labia minora (HP:0012880)2.24761808
95Abnormality of macular pigmentation (HP:0008002)2.24396381
96Type 1 muscle fiber predominance (HP:0003803)2.22654162
97Bony spicule pigmentary retinopathy (HP:0007737)2.22341993
98Sclerocornea (HP:0000647)2.20384058
99Thyroid-stimulating hormone excess (HP:0002925)2.19972841
100Exotropia (HP:0000577)2.19400497
101Subcapsular cataract (HP:0000523)2.17053300
102Aplasia/Hypoplasia involving the musculature (HP:0001460)2.15323224
103Abnormality of the pons (HP:0007361)2.14923794
104Hemiparesis (HP:0001269)2.14890030
105Tubular atrophy (HP:0000092)2.14609554
106Increased corneal curvature (HP:0100692)2.12951115
107Keratoconus (HP:0000563)2.12951115
108Abnormal rod and cone electroretinograms (HP:0008323)2.12828049
109Stroke (HP:0001297)2.11650471
110Postaxial foot polydactyly (HP:0001830)2.10607996
111Fair hair (HP:0002286)2.10445756
112Abnormal drinking behavior (HP:0030082)2.08263634
113Polydipsia (HP:0001959)2.08263634
114Hyporeflexia of lower limbs (HP:0002600)2.08155976
115Atrophic scars (HP:0001075)2.07749834
116Dysostosis multiplex (HP:0000943)2.06130422
117Abnormality of the lumbar spine (HP:0100712)2.04705663
118Osteolytic defects of the phalanges of the hand (HP:0009771)2.02933111
119Osteolytic defects of the hand bones (HP:0009699)2.02933111
120Poor coordination (HP:0002370)2.02479975
121Congenital hepatic fibrosis (HP:0002612)2.01935974
122Stomach cancer (HP:0012126)2.01799365
123Retinal dysplasia (HP:0007973)2.01497267
124Sensorimotor neuropathy (HP:0007141)2.00865571
125Abnormality of the labia majora (HP:0012881)2.00831903
126Postaxial hand polydactyly (HP:0001162)2.00018672
127Amyotrophic lateral sclerosis (HP:0007354)1.99874443
128Pachygyria (HP:0001302)1.97787965
129Bile duct proliferation (HP:0001408)1.97199412
130Abnormal biliary tract physiology (HP:0012439)1.97199412
131Focal seizures (HP:0007359)1.97003992
132Abnormality of the shoulder girdle musculature (HP:0001435)1.96233550
133Ureteral stenosis (HP:0000071)1.95945548
134Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95647428
135Decreased central vision (HP:0007663)1.95605617
136Thyroiditis (HP:0100646)1.95589517
137Short tibia (HP:0005736)1.95120677
138Spastic diplegia (HP:0001264)1.95116056
139Aplasia/Hypoplasia of the ulna (HP:0006495)1.94881937
140Ureteral obstruction (HP:0006000)1.94678917
141Bicuspid aortic valve (HP:0001647)1.94298128
142Scapular winging (HP:0003691)1.93580560
143Increased density of long bones (HP:0006392)1.93186424
144Achilles tendon contracture (HP:0001771)1.93129483
145Occipital encephalocele (HP:0002085)1.91639512
146Anencephaly (HP:0002323)1.91152254
147Ketosis (HP:0001946)1.90342667
148Hypoproteinemia (HP:0003075)1.89042463
149Cortical dysplasia (HP:0002539)1.89005450
150Male pseudohermaphroditism (HP:0000037)1.88946048
151Short hallux (HP:0010109)1.88597252
152Constricted visual fields (HP:0001133)1.88362259
153Chorioretinal atrophy (HP:0000533)1.88022829
154Ketoacidosis (HP:0001993)1.87947661
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86636553
156Abnormal protein N-linked glycosylation (HP:0012347)1.86636553
157Abnormal protein glycosylation (HP:0012346)1.86636553
158Abnormal glycosylation (HP:0012345)1.86636553
159Protruding tongue (HP:0010808)1.86347610
160Increased CSF lactate (HP:0002490)1.86081959
161Sandal gap (HP:0001852)1.85801918
162Small hand (HP:0200055)1.85706733
163Restlessness (HP:0000711)1.84551309
164Methylmalonic acidemia (HP:0002912)1.84049978
165Widely spaced teeth (HP:0000687)1.83825559
166Abnormality of the Achilles tendon (HP:0005109)1.83332007
167Ectopia lentis (HP:0001083)1.82473676
168Exocrine pancreatic insufficiency (HP:0001738)1.82231384
169Polyphagia (HP:0002591)1.81912552
170Methylmalonic aciduria (HP:0012120)1.80739961
171Cerebral aneurysm (HP:0004944)1.79725643
172Pendular nystagmus (HP:0012043)1.79054463
173Menorrhagia (HP:0000132)1.78802349
174Dynein arm defect of respiratory motile cilia (HP:0012255)1.78236405
175Absent/shortened dynein arms (HP:0200106)1.78236405
176Polyuria (HP:0000103)1.78063571
177Short foot (HP:0001773)1.77907838
178Focal segmental glomerulosclerosis (HP:0000097)1.77502609
179Milia (HP:0001056)1.77471408
180Large for gestational age (HP:0001520)1.77243605
181Astigmatism (HP:0000483)1.76777933
182Clumsiness (HP:0002312)1.76531806
183Retinitis pigmentosa (HP:0000510)1.76524969
184Autoimmune thrombocytopenia (HP:0001973)1.76230907
185Hepatocellular necrosis (HP:0001404)1.75588264
186Neoplasm of the adrenal cortex (HP:0100641)1.75405536
187Dialeptic seizures (HP:0011146)1.75265762
188Hypoalbuminemia (HP:0003073)1.75056864
189Aplasia/Hypoplasia of the hallux (HP:0008362)1.72952466
190Calf muscle hypertrophy (HP:0008981)1.72654646
191Radial bowing (HP:0002986)1.72557889
192Mask-like facies (HP:0000298)1.72343605
193Abnormality of sulfur amino acid metabolism (HP:0004339)1.69278460
194Congenital glaucoma (HP:0001087)1.59666240
195Colon cancer (HP:0003003)1.59409041
196Hand muscle atrophy (HP:0009130)1.59190273
197Intention tremor (HP:0002080)1.57737216
198Degeneration of the lateral corticospinal tracts (HP:0002314)1.56298050
199Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.56298050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT39.83183305
2TAOK35.14127940
3FRK4.11671927
4MAP4K23.85981584
5PDK23.75053364
6MYLK3.34071950
7EEF2K3.11891409
8STK392.73911448
9WNK32.71452951
10BMPR1B2.70405270
11MST42.64115742
12TTN2.48200277
13LATS12.36477831
14BCKDK2.33948541
15ADRBK22.23358772
16TNK22.14888418
17ACVR1B2.07870585
18MAPK132.05774111
19CASK2.03796963
20MAP3K22.03196376
21PINK11.93114067
22TLK11.92034644
23BCR1.87990132
24GRK11.84786191
25ZAK1.71968464
26SCYL21.66871347
27MAPKAPK31.57672839
28PIK3CG1.53859087
29TXK1.50719076
30PTK61.48043225
31MARK11.35833209
32SIK11.35078573
33OXSR11.33769918
34ERN11.25593968
35TNIK1.24780090
36EIF2AK31.24178562
37STK38L1.21276727
38MKNK21.20715698
39DMPK1.19679323
40NTRK31.18844643
41NEK61.17740126
42PAK21.16941931
43RPS6KB21.14818530
44TRIM281.12146840
45PIK3CA1.11385595
46LRRK21.10934800
47PLK21.10037259
48TRIB31.07491181
49LMTK21.05844434
50FER1.03540316
51PRKCE1.03008638
52TEC0.98377886
53MAP2K70.96675736
54PDGFRA0.95533066
55TRPM70.95454038
56PRKCG0.94326881
57MAP3K30.94156383
58CSNK1G10.93056385
59ADRBK10.92364623
60CSNK1G20.91273167
61DAPK20.89792121
62CSNK1G30.89470223
63ERBB30.84861987
64CSNK1A1L0.82563041
65TYK20.80756182
66EPHA20.79849056
67DYRK20.74399580
68CSF1R0.74363633
69NUAK10.74283922
70MKNK10.73762696
71RIPK10.65723354
72NTRK20.65409467
73MAPK120.65321637
74DDR20.64229770
75EPHA40.63843490
76CAMK1G0.63083692
77TESK10.60758785
78PKN20.60738612
79JAK30.60044451
80ITK0.60023467
81PTK2B0.59996034
82JAK20.59010227
83BMX0.58426260
84PLK40.57758414
85CAMK2A0.57714853
86STK100.55415487
87MST1R0.54819046
88GRK70.53784214
89RPS6KA20.53165507
90TGFBR10.52548604
91PDPK10.50636138
92PRKCQ0.50577604
93CDC42BPA0.49984031
94IKBKB0.49303845
95MET0.49208882
96PRKAA20.49066742
97MAPKAPK50.49044417
98NME10.47056800
99PRKACA0.45575183
100CDK30.45446561
101BRSK20.45330093
102OBSCN0.42439336
103PKN10.42322616
104VRK10.41573627
105MINK10.41498430
106PDK10.41420520
107TIE10.41085735
108PDK30.41075379
109PDK40.41075379
110STK30.40946342
111ABL10.40745368
112CSNK1A10.40397066
113PRKAA10.39839230
114PTK20.38835265
115PAK30.38564320
116ROCK20.38320423
117CSNK1D0.38258046
118ROCK10.37909718
119MUSK0.37681208
120KIT0.37515990
121ATM0.37307683
122PRKG10.37205671
123MAP2K60.37173511
124CAMK1D0.36706289
125MTOR0.36219662
126FYN0.35577346
127JAK10.34648650
128RET0.34225892
129STK380.32969371
130SGK20.32923529
131KDR0.32896535
132EGFR0.32709416
133IGF1R0.32513681
134PRKCZ0.31789679
135GRK50.31661418
136PLK30.30900909
137IRAK10.30878987
138PDGFRB0.30393203
139STK110.30265324
140PLK10.29902570
141PRKCA0.29620809
142FGFR20.29053062
143NTRK10.28797377
144PRKCI0.26208974
145LATS20.26023874
146MAPK70.25739671
147INSRR0.24430827
148CAMKK10.23361853
149CAMK2G0.22173555
150INSR0.22092377
151ERBB20.21980788
152DAPK30.20110039
153MAP2K20.19109731
154WNK40.18198828
155GSK3A0.16374243
156PHKG20.15986392
157PHKG10.15986392
158MELK0.14839985
159MAP3K40.14131803
160CAMKK20.13752350
161LIMK10.13629170
162EPHB10.13209079
163MAP3K70.12800249
164FGR0.12209169
165MATK0.11246295
166DYRK1B0.11233843
167SRC0.10892945
168CAMK10.10068286
169PRKD10.09920425
170WNK10.09492126
171PRKACB0.08754944
172MAP3K80.08677844
173KSR20.07323498
174CDK50.07079471

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004305.76138333
2Sulfur metabolism_Homo sapiens_hsa009204.42168954
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.26475077
4Nitrogen metabolism_Homo sapiens_hsa009103.44801444
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.05102660
6Butanoate metabolism_Homo sapiens_hsa006502.92965687
7Phototransduction_Homo sapiens_hsa047442.89695088
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.80831312
9N-Glycan biosynthesis_Homo sapiens_hsa005102.78703044
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52085557
11Linoleic acid metabolism_Homo sapiens_hsa005912.44634611
12Protein export_Homo sapiens_hsa030602.41591849
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39143943
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.33404511
15Nicotine addiction_Homo sapiens_hsa050332.31345191
16Tryptophan metabolism_Homo sapiens_hsa003802.04012639
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01434961
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93560650
19Ether lipid metabolism_Homo sapiens_hsa005651.78942996
20Homologous recombination_Homo sapiens_hsa034401.77702717
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.77235153
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72355381
23Fanconi anemia pathway_Homo sapiens_hsa034601.71079566
24Caffeine metabolism_Homo sapiens_hsa002321.62207596
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.60457365
26Basal transcription factors_Homo sapiens_hsa030221.58968384
27Taste transduction_Homo sapiens_hsa047421.55931468
28Lysosome_Homo sapiens_hsa041421.51723935
29Selenocompound metabolism_Homo sapiens_hsa004501.51087500
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47187090
31Olfactory transduction_Homo sapiens_hsa047401.44577713
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.43408910
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43117067
34Morphine addiction_Homo sapiens_hsa050321.41587060
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39214839
36Other glycan degradation_Homo sapiens_hsa005111.38700773
37Arginine biosynthesis_Homo sapiens_hsa002201.37810315
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36097049
39RNA polymerase_Homo sapiens_hsa030201.34508164
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.33872933
41beta-Alanine metabolism_Homo sapiens_hsa004101.33557243
42Tight junction_Homo sapiens_hsa045301.33510059
43Regulation of autophagy_Homo sapiens_hsa041401.31952069
44Focal adhesion_Homo sapiens_hsa045101.28733161
45GABAergic synapse_Homo sapiens_hsa047271.23295635
46Peroxisome_Homo sapiens_hsa041461.21658669
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19351878
48Retinol metabolism_Homo sapiens_hsa008301.17969331
49Salivary secretion_Homo sapiens_hsa049701.17925536
50Gastric acid secretion_Homo sapiens_hsa049711.17074513
51Oxidative phosphorylation_Homo sapiens_hsa001901.16864952
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14678891
53Glutamatergic synapse_Homo sapiens_hsa047241.14036462
54Circadian entrainment_Homo sapiens_hsa047131.14017052
55Chemical carcinogenesis_Homo sapiens_hsa052041.13030033
56Arachidonic acid metabolism_Homo sapiens_hsa005901.09986708
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07258114
58Non-homologous end-joining_Homo sapiens_hsa034501.03020359
59ECM-receptor interaction_Homo sapiens_hsa045121.00025022
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99781261
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.99638585
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98819787
63Serotonergic synapse_Homo sapiens_hsa047260.98231480
64Adherens junction_Homo sapiens_hsa045200.96877342
65Vibrio cholerae infection_Homo sapiens_hsa051100.95225535
66Hippo signaling pathway_Homo sapiens_hsa043900.94902925
67Prolactin signaling pathway_Homo sapiens_hsa049170.92722714
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92041697
69Inositol phosphate metabolism_Homo sapiens_hsa005620.91950812
70Amoebiasis_Homo sapiens_hsa051460.90605626
71Mineral absorption_Homo sapiens_hsa049780.90359177
72Glycerolipid metabolism_Homo sapiens_hsa005610.88474936
73Protein digestion and absorption_Homo sapiens_hsa049740.87667306
74Thyroid hormone synthesis_Homo sapiens_hsa049180.87384102
75RNA degradation_Homo sapiens_hsa030180.86210547
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85880099
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85791575
78Collecting duct acid secretion_Homo sapiens_hsa049660.85689957
79Proteoglycans in cancer_Homo sapiens_hsa052050.83749437
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83286665
81Parkinsons disease_Homo sapiens_hsa050120.82845287
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.82199996
83Small cell lung cancer_Homo sapiens_hsa052220.82029822
84Type I diabetes mellitus_Homo sapiens_hsa049400.80737804
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.80735384
86Endometrial cancer_Homo sapiens_hsa052130.79000691
87Ovarian steroidogenesis_Homo sapiens_hsa049130.78545954
88Fatty acid metabolism_Homo sapiens_hsa012120.77386178
89Insulin resistance_Homo sapiens_hsa049310.77351731
90Circadian rhythm_Homo sapiens_hsa047100.75759246
91Chronic myeloid leukemia_Homo sapiens_hsa052200.75547185
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74697253
93Calcium signaling pathway_Homo sapiens_hsa040200.73971739
94TGF-beta signaling pathway_Homo sapiens_hsa043500.73477739
95Dopaminergic synapse_Homo sapiens_hsa047280.73371321
96Prostate cancer_Homo sapiens_hsa052150.72458866
97Renin secretion_Homo sapiens_hsa049240.72180605
98Propanoate metabolism_Homo sapiens_hsa006400.70370878
99Dorso-ventral axis formation_Homo sapiens_hsa043200.68435614
100Histidine metabolism_Homo sapiens_hsa003400.68391567
101ErbB signaling pathway_Homo sapiens_hsa040120.68273272
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68067056
103Renin-angiotensin system_Homo sapiens_hsa046140.67552777
104mTOR signaling pathway_Homo sapiens_hsa041500.67317735
105Fat digestion and absorption_Homo sapiens_hsa049750.66255960
106Platelet activation_Homo sapiens_hsa046110.65886716
107Estrogen signaling pathway_Homo sapiens_hsa049150.65161425
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64043965
109Fructose and mannose metabolism_Homo sapiens_hsa000510.63957429
110Purine metabolism_Homo sapiens_hsa002300.63493319
111Fatty acid degradation_Homo sapiens_hsa000710.62800599
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61876279
113Bile secretion_Homo sapiens_hsa049760.61390292
114Oxytocin signaling pathway_Homo sapiens_hsa049210.61243665
115Pancreatic secretion_Homo sapiens_hsa049720.60323908
116Huntingtons disease_Homo sapiens_hsa050160.60111759
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59482609
118Long-term depression_Homo sapiens_hsa047300.57974435
119Fatty acid elongation_Homo sapiens_hsa000620.56980661
120Acute myeloid leukemia_Homo sapiens_hsa052210.56520067
121Primary immunodeficiency_Homo sapiens_hsa053400.56304780
122Metabolic pathways_Homo sapiens_hsa011000.56254415
123Graft-versus-host disease_Homo sapiens_hsa053320.55483177
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54266040
125ABC transporters_Homo sapiens_hsa020100.53662998
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53227524
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53100647
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50101652
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49801408
130Glioma_Homo sapiens_hsa052140.49596816
131Sphingolipid metabolism_Homo sapiens_hsa006000.49070129
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48578048
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48448010
134Dilated cardiomyopathy_Homo sapiens_hsa054140.48413763
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47566478
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47552755
137Hepatitis C_Homo sapiens_hsa051600.46495020
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46290538
139Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45631423
140Autoimmune thyroid disease_Homo sapiens_hsa053200.44609728
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43998624
142Gap junction_Homo sapiens_hsa045400.42913720
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42671216
144Insulin signaling pathway_Homo sapiens_hsa049100.41724677
145AMPK signaling pathway_Homo sapiens_hsa041520.41492753
146Alzheimers disease_Homo sapiens_hsa050100.41038600
147Long-term potentiation_Homo sapiens_hsa047200.40756498
148Steroid biosynthesis_Homo sapiens_hsa001000.40583797
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40494704
150Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39937058
151Amphetamine addiction_Homo sapiens_hsa050310.39801275
152Insulin secretion_Homo sapiens_hsa049110.39610023
153Melanoma_Homo sapiens_hsa052180.39334598
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39017939
155Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37468621
156cAMP signaling pathway_Homo sapiens_hsa040240.37068341
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36831136
158Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36667080
159Cardiac muscle contraction_Homo sapiens_hsa042600.36485779
160Allograft rejection_Homo sapiens_hsa053300.36320161
161Pancreatic cancer_Homo sapiens_hsa052120.35528517
162Cholinergic synapse_Homo sapiens_hsa047250.35176353
163Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34892358
164Cocaine addiction_Homo sapiens_hsa050300.34772165
165Lysine degradation_Homo sapiens_hsa003100.34670507
166Fatty acid biosynthesis_Homo sapiens_hsa000610.34399052
167Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33948309
168Adipocytokine signaling pathway_Homo sapiens_hsa049200.33865573
169Intestinal immune network for IgA production_Homo sapiens_hsa046720.33750585
170Bladder cancer_Homo sapiens_hsa052190.33176128
171Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31302481
172Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29671652
173Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29406633
174Non-small cell lung cancer_Homo sapiens_hsa052230.28372721
175Endocytosis_Homo sapiens_hsa041440.27911798
176Thyroid cancer_Homo sapiens_hsa052160.27431421
177PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27324931
178GnRH signaling pathway_Homo sapiens_hsa049120.27162252
179Rap1 signaling pathway_Homo sapiens_hsa040150.25805889

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