PATL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.82908247
2negative regulation of cell killing (GO:0031342)5.82908247
3mitotic metaphase plate congression (GO:0007080)5.76267490
4positive regulation of gamma-delta T cell activation (GO:0046645)5.73466401
5regulation of B cell receptor signaling pathway (GO:0050855)5.70830891
6piRNA metabolic process (GO:0034587)5.68328883
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.61159691
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.02864065
9protein localization to kinetochore (GO:0034501)4.99520838
10metaphase plate congression (GO:0051310)4.87734072
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84495303
12antigen processing and presentation of endogenous antigen (GO:0019883)4.61014116
13positive regulation of humoral immune response (GO:0002922)4.58854771
14ribosome assembly (GO:0042255)4.45816819
15response to interleukin-15 (GO:0070672)4.44534076
16protein K6-linked ubiquitination (GO:0085020)4.43276573
17regulation of gamma-delta T cell activation (GO:0046643)4.41006043
18negative T cell selection (GO:0043383)4.39944328
19cellular response to interleukin-15 (GO:0071350)4.39100350
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.33570006
21negative thymic T cell selection (GO:0045060)4.32161455
22protein localization to chromosome, centromeric region (GO:0071459)4.31740796
23establishment of chromosome localization (GO:0051303)4.30636324
24histone H2A monoubiquitination (GO:0035518)4.27814984
25regulation of gamma-delta T cell differentiation (GO:0045586)4.24009432
26DNA replication initiation (GO:0006270)4.17323479
27regulation of mitotic spindle organization (GO:0060236)4.16101939
28mitotic chromosome condensation (GO:0007076)4.16039511
29attachment of spindle microtubules to kinetochore (GO:0008608)4.13893840
30immunoglobulin mediated immune response (GO:0016064)4.13847039
31regulation of spindle organization (GO:0090224)4.12184588
32DNA replication checkpoint (GO:0000076)4.09981447
33DNA methylation involved in gamete generation (GO:0043046)4.09353512
34negative regulation of histone methylation (GO:0031061)4.07979059
35positive regulation of chromosome segregation (GO:0051984)4.00909382
36mitotic sister chromatid segregation (GO:0000070)3.94434096
37activated T cell proliferation (GO:0050798)3.94136793
38T cell migration (GO:0072678)3.93192936
39positive thymic T cell selection (GO:0045059)3.91326246
40base-excision repair, AP site formation (GO:0006285)3.88558797
41mitotic nuclear envelope disassembly (GO:0007077)3.84353782
42DNA replication-dependent nucleosome organization (GO:0034723)3.81255056
43DNA replication-dependent nucleosome assembly (GO:0006335)3.81255056
44positive T cell selection (GO:0043368)3.80846838
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.80176338
46regulation of histone H3-K27 methylation (GO:0061085)3.77232144
47histone H2A ubiquitination (GO:0033522)3.76938420
48regulation of telomere maintenance via telomerase (GO:0032210)3.75769683
49DNA strand elongation involved in DNA replication (GO:0006271)3.74115513
50B cell receptor signaling pathway (GO:0050853)3.73131717
51negative regulation of T cell mediated immunity (GO:0002710)3.72671640
52positive regulation of granulocyte differentiation (GO:0030854)3.71554338
53regulation of gene silencing by RNA (GO:0060966)3.71289239
54regulation of posttranscriptional gene silencing (GO:0060147)3.71289239
55regulation of gene silencing by miRNA (GO:0060964)3.71289239
56receptor recycling (GO:0001881)3.69294152
57regulation of acrosome reaction (GO:0060046)3.69238459
58leukocyte aggregation (GO:0070486)3.68714775
59negative regulation of meiosis (GO:0045835)3.63764836
60chromatin remodeling at centromere (GO:0031055)3.63558695
61interferon-gamma production (GO:0032609)3.63038229
62positive regulation of mitotic sister chromatid separation (GO:1901970)3.62674218
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.62674218
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.62674218
65membrane disassembly (GO:0030397)3.61823132
66nuclear envelope disassembly (GO:0051081)3.61823132
67positive regulation of B cell differentiation (GO:0045579)3.60987396
68modulation by symbiont of host immune response (GO:0052553)3.59102362
69positive regulation by symbiont of host defense response (GO:0052509)3.59102362
70modulation by symbiont of host defense response (GO:0052031)3.59102362
71modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59102362
72modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59102362
73positive regulation by organism of defense response of other organism involved in symbiotic interact3.59102362
74somatic diversification of immune receptors via somatic mutation (GO:0002566)3.56951676
75somatic hypermutation of immunoglobulin genes (GO:0016446)3.56951676
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.56186855
77folic acid metabolic process (GO:0046655)3.55707567
78regulation of B cell differentiation (GO:0045577)3.55565814
79CENP-A containing nucleosome assembly (GO:0034080)3.55453534
80negative regulation of interleukin-12 production (GO:0032695)3.54868260
81DNA strand elongation (GO:0022616)3.54511718
82regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.53256591
83regulation of alpha-beta T cell proliferation (GO:0046640)3.52498495
84negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.52116803
85neutrophil activation involved in immune response (GO:0002283)3.51928914
86formation of translation preinitiation complex (GO:0001731)3.49420277
87regulation of sister chromatid cohesion (GO:0007063)3.47670638
88spindle checkpoint (GO:0031577)3.45913728
89negative regulation of chromosome segregation (GO:0051985)3.45673011
90protein localization to chromosome (GO:0034502)3.43721522
91regulation of T cell mediated cytotoxicity (GO:0001914)3.43489672
92regulation of chromosome segregation (GO:0051983)3.41653369
93folic acid-containing compound biosynthetic process (GO:0009396)3.41610493
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41317389
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.41188253
96histone exchange (GO:0043486)3.41163585
97determination of adult lifespan (GO:0008340)3.40577297
98neutrophil activation (GO:0042119)3.40388058
99gene silencing by RNA (GO:0031047)3.39684767
100B cell mediated immunity (GO:0019724)3.39166248
101interferon-gamma secretion (GO:0072643)3.38832955
102DNA replication-independent nucleosome assembly (GO:0006336)3.38207429
103DNA replication-independent nucleosome organization (GO:0034724)3.38207429
104regulation of regulatory T cell differentiation (GO:0045589)3.37669008
105negative regulation of leukocyte mediated immunity (GO:0002704)3.37442938
106cellular response to type I interferon (GO:0071357)3.37080656
107type I interferon signaling pathway (GO:0060337)3.37080656
108T cell selection (GO:0045058)3.36776614
109regulation of mitotic metaphase/anaphase transition (GO:0030071)3.36726769
110meiotic chromosome segregation (GO:0045132)3.36472705
111regulation of female gonad development (GO:2000194)3.36440527
112response to type I interferon (GO:0034340)3.35348362
113protein kinase C signaling (GO:0070528)3.34822016
114negative regulation of mitotic sister chromatid separation (GO:2000816)3.34736791
115negative regulation of mitotic sister chromatid segregation (GO:0033048)3.34736791
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.34736791
117negative regulation of sister chromatid segregation (GO:0033046)3.34736791
118regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.33425978
119regulation of natural killer cell mediated immunity (GO:0002715)3.33425978
120nuclear pore organization (GO:0006999)3.32754131
121regulation of histone H3-K9 methylation (GO:0051570)3.32608368
122mitotic spindle checkpoint (GO:0071174)3.31207304
123female gamete generation (GO:0007292)3.31134789
124regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.31041956
125telomere maintenance via semi-conservative replication (GO:0032201)3.29382878
126mitotic spindle assembly checkpoint (GO:0007094)3.28868033
127multicellular organism reproduction (GO:0032504)3.28485703
128regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28302774
129tolerance induction (GO:0002507)3.28115750
130regulation of sister chromatid segregation (GO:0033045)3.27334492
131regulation of mitotic sister chromatid separation (GO:0010965)3.27334492
132regulation of mitotic sister chromatid segregation (GO:0033047)3.27334492
133cellular extravasation (GO:0045123)3.27169148
134negative regulation of T-helper cell differentiation (GO:0045623)3.25812349
135negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.25812349
136sister chromatid segregation (GO:0000819)3.25353777
137regulation of centriole replication (GO:0046599)3.24849267
138spindle assembly checkpoint (GO:0071173)3.22980262
139regulation of hypersensitivity (GO:0002883)3.22795713
140detection of other organism (GO:0098543)3.21109010
141thymic T cell selection (GO:0045061)3.19738109
142cytidine metabolic process (GO:0046087)3.19508232
143cytidine catabolic process (GO:0006216)3.19508232
144cytidine deamination (GO:0009972)3.19508232
145regulation of helicase activity (GO:0051095)3.18672750
146regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17476346
147positive regulation of alpha-beta T cell proliferation (GO:0046641)3.17230611
148regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17142120
149regulation of centrosome cycle (GO:0046605)3.15768486
150nucleobase biosynthetic process (GO:0046112)3.15741012
151purine nucleobase biosynthetic process (GO:0009113)3.13659083
152positive regulation of T cell mediated cytotoxicity (GO:0001916)3.13187332
153proteasome assembly (GO:0043248)3.12654890
154regulation of DNA methylation (GO:0044030)3.12639245
155DNA unwinding involved in DNA replication (GO:0006268)3.12617954
156detection of bacterium (GO:0016045)3.12601590
157ribosome biogenesis (GO:0042254)3.12465781
158kinetochore organization (GO:0051383)3.12463446
159granulocyte activation (GO:0036230)3.11694305
160macrophage activation involved in immune response (GO:0002281)3.11334149
161regulation of T cell tolerance induction (GO:0002664)3.10132994
162positive regulation of isotype switching (GO:0045830)3.10086592
163regulation of double-strand break repair via homologous recombination (GO:0010569)3.09316252
164maturation of 5.8S rRNA (GO:0000460)3.09251058
165antigen receptor-mediated signaling pathway (GO:0050851)3.08704919
166negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.08139428
167chromosome segregation (GO:0007059)3.07817997
168regulation of leukocyte mediated cytotoxicity (GO:0001910)3.07801183
169regulation of nuclear cell cycle DNA replication (GO:0033262)3.07466981
170DNA deamination (GO:0045006)3.06201344
171telomere maintenance via recombination (GO:0000722)3.05364127
172DNA alkylation (GO:0006305)3.04834815
173DNA methylation (GO:0006306)3.04834815
174kinetochore assembly (GO:0051382)3.04635717
175synaptonemal complex assembly (GO:0007130)3.04368924
176nuclear pore complex assembly (GO:0051292)3.04273650
177myeloid cell activation involved in immune response (GO:0002275)3.03878714
178mast cell activation (GO:0045576)3.03645776
179regulation of tolerance induction (GO:0002643)3.02530266
180intestinal epithelial cell development (GO:0060576)3.02500811
181pyrimidine ribonucleoside catabolic process (GO:0046133)3.02453858
182negative regulation of B cell proliferation (GO:0030889)2.99107339
183oocyte development (GO:0048599)2.97954212
184defense response to protozoan (GO:0042832)2.97854508
185leukocyte degranulation (GO:0043299)2.93702188
186positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.93514414
187negative regulation of adaptive immune response (GO:0002820)2.90631476
188positive regulation of DNA recombination (GO:0045911)2.90118525
189negative regulation of alpha-beta T cell activation (GO:0046636)2.89872634
190positive regulation of interleukin-4 production (GO:0032753)2.89101240
191regulation of interferon-beta biosynthetic process (GO:0045357)2.88790387
192regulation of cell killing (GO:0031341)2.88591003
193T cell receptor signaling pathway (GO:0050852)2.88501824
194regulation of T cell mediated immunity (GO:0002709)2.87876379
195positive regulation of defense response to virus by host (GO:0002230)2.87050046
196positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.87003961
197positive regulation of tolerance induction (GO:0002645)2.86600392
198negative regulation of innate immune response (GO:0045824)2.85900699
199interferon-gamma-mediated signaling pathway (GO:0060333)2.84385610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.56462362
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.81984202
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.40565026
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.16452455
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.25152493
6EZH2_22144423_ChIP-Seq_EOC_Human4.23275295
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.84889469
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.68100788
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.52660347
10RUNX_20019798_ChIP-Seq_JUKART_Human3.45277557
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.32394873
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23249360
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14716612
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02217653
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92042628
16MYB_26560356_Chip-Seq_TH2_Human2.87806575
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70602577
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65844576
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65741929
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.61217855
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.55110419
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50917292
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.48093614
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.46781585
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.46781585
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.46781585
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.46462873
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46394939
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.42307529
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40917002
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.40232692
32MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38420994
33NOTCH1_21737748_ChIP-Seq_TLL_Human2.36416316
34SMAD_19615063_ChIP-ChIP_OVARY_Human2.33061140
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33045818
36ETS1_20019798_ChIP-Seq_JURKAT_Human2.28949209
37MYB_26560356_Chip-Seq_TH1_Human2.28559740
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28209553
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27758815
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24859315
41EST1_17652178_ChIP-ChIP_JURKAT_Human2.22119113
42SCL_19346495_ChIP-Seq_HPC-7_Human2.19138931
43NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17721302
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17620644
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17258758
46* GATA3_27048872_Chip-Seq_THYMUS_Human2.15529282
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14469525
48STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11880140
49GABP_17652178_ChIP-ChIP_JURKAT_Human2.11457904
50AR_21909140_ChIP-Seq_LNCAP_Human2.11028416
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.09880261
52CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03572932
53MYCN_18555785_ChIP-Seq_MESCs_Mouse2.03404679
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00548324
55E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00353341
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98896718
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98298031
58SPI1_23547873_ChIP-Seq_NB4_Human1.96840777
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94125200
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92392261
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.91159469
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.90468028
63SPI1_23127762_ChIP-Seq_K562_Human1.89210568
64GATA3_26560356_Chip-Seq_TH2_Human1.87979349
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.86466155
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.79611349
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75916065
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73231074
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72799996
70MAF_26560356_Chip-Seq_TH1_Human1.70881030
71VDR_23849224_ChIP-Seq_CD4+_Human1.69005050
72* UTX_26944678_Chip-Seq_JUKART_Human1.67654957
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65982189
74VDR_24787735_ChIP-Seq_THP-1_Human1.65504460
75XRN2_22483619_ChIP-Seq_HELA_Human1.64266249
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63426185
77TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61075055
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.58265539
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.56624318
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56560763
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56079696
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.55271545
83DCP1A_22483619_ChIP-Seq_HELA_Human1.54364146
84TFEB_21752829_ChIP-Seq_HELA_Human1.54098982
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53148304
86VDR_24763502_ChIP-Seq_THP-1_Human1.52559279
87GABP_19822575_ChIP-Seq_HepG2_Human1.50981215
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50137529
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.49580521
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43461516
91RUNX1_22412390_ChIP-Seq_EML_Mouse1.41139926
92FOXP3_21729870_ChIP-Seq_TREG_Human1.41044383
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41029826
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40359879
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.38315690
96SMRT_27268052_Chip-Seq_Bcells_Human1.38188167
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37910169
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36287209
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35940266
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34015644
101TTF2_22483619_ChIP-Seq_HELA_Human1.33553783
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33479536
103* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33042926
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31146336
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28831145
106CIITA_25753668_ChIP-Seq_RAJI_Human1.28286654
107KDM5A_27292631_Chip-Seq_BREAST_Human1.27795266
108EGR1_19374776_ChIP-ChIP_THP-1_Human1.24368881
109ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24295461
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24162955
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.23836696
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21997314
113HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20444889
114GATA1_22025678_ChIP-Seq_K562_Human1.20236431
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19699441
116* MAF_26560356_Chip-Seq_TH2_Human1.18976301
117NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18485192
118NANOG_18692474_ChIP-Seq_MESCs_Mouse1.18055709
119SRF_21415370_ChIP-Seq_HL-1_Mouse1.17841814
120SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17671630
121POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17434269
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15326538
123BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15031371
124SOX2_18692474_ChIP-Seq_MESCs_Mouse1.14927222
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13011297
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10836210
127OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10507926
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10406986
129GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10404570
130GATA1_19941827_ChIP-Seq_MEL_Mouse1.10306980
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09242723
132STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08277684
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07980692
134GATA3_26560356_Chip-Seq_TH1_Human1.05928615
135DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05699206
136VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05514040
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.04965211
138KAP1_27257070_Chip-Seq_ESCs_Mouse1.04710356
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04560893
140POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02471946
141CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02232291
142* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02060435
143VDR_21846776_ChIP-Seq_THP-1_Human1.01555771
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00878711
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99492864
146FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99056416
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98689528
148TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96657092
149SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96407307
150KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96331436
151RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95988428
152TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94810096
153CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94414282
154CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94180339
155HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94145767
156PU_27001747_Chip-Seq_BMDM_Mouse0.91979936
157CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91046596
158FLI1_27457419_Chip-Seq_LIVER_Mouse0.89942681
159TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89863868
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87820548
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87637640
162ELK1_19687146_ChIP-ChIP_HELA_Human0.87602255
163EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87438500
164MYC_22102868_ChIP-Seq_BL_Human0.86665522
165BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86383838
166TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86253226
167KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85963696
168CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85418394
169GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85167244
170GATA1_19941826_ChIP-Seq_K562_Human0.83587044
171KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80979399
172TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80971199
173ER_23166858_ChIP-Seq_MCF-7_Human0.80707633
174CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80003213
175GATA2_21666600_ChIP-Seq_HMVEC_Human0.79496982
176CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79277639
177RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79276380
178IRF1_19129219_ChIP-ChIP_H3396_Human0.79260185
179FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78786728
180NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78697063
181GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77063211
182GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76700516
183GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76162644
184EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75597866
185GATA2_19941826_ChIP-Seq_K562_Human0.75534490
186ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.75264028
187TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74747438
188NANOG_20526341_ChIP-Seq_ESCs_Human0.72828123
189CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72615822
190BCAT_22108803_ChIP-Seq_LS180_Human0.72107062
191GATA3_21878914_ChIP-Seq_MCF-7_Human0.71947133
192TCF7_22412390_ChIP-Seq_EML_Mouse0.71945147
193SALL4_22934838_ChIP-ChIP_CD34+_Human0.71511752
194KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.69314687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.47775027
2MP0003111_abnormal_nucleus_morphology4.76825935
3MP0010094_abnormal_chromosome_stability4.67952503
4MP0004957_abnormal_blastocyst_morpholog4.44158619
5MP0003718_maternal_effect4.19027243
6MP0005671_abnormal_response_to4.05418899
7MP0001835_abnormal_antigen_presentation3.88796749
8MP0003077_abnormal_cell_cycle3.82945656
9MP0003724_increased_susceptibility_to3.78733562
10MP0008877_abnormal_DNA_methylation3.65431718
11MP0003763_abnormal_thymus_physiology3.59969437
12MP0008057_abnormal_DNA_replication3.32474942
13MP0001800_abnormal_humoral_immune3.29792370
14MP0003806_abnormal_nucleotide_metabolis3.27010849
15MP0008058_abnormal_DNA_repair3.26159437
16MP0003436_decreased_susceptibility_to3.17425628
17MP0005000_abnormal_immune_tolerance2.98432266
18MP0000685_abnormal_immune_system2.82103503
19MP0002723_abnormal_immune_serum2.81836463
20MP0005387_immune_system_phenotype2.77634322
21MP0001790_abnormal_immune_system2.77634322
22MP0002420_abnormal_adaptive_immunity2.71304069
23MP0001819_abnormal_immune_cell2.66428818
24MP0009785_altered_susceptibility_to2.65469856
25MP0005025_abnormal_response_to2.63531622
26MP0002452_abnormal_antigen_presenting2.62634946
27MP0002419_abnormal_innate_immunity2.52599026
28MP0008932_abnormal_embryonic_tissue2.41537234
29MP0003303_peritoneal_inflammation2.41293331
30MP0001730_embryonic_growth_arrest2.35683567
31MP0010352_gastrointestinal_tract_polyps2.28786324
32MP0006082_CNS_inflammation2.26895970
33MP0002398_abnormal_bone_marrow2.26820365
34MP0002148_abnormal_hypersensitivity_rea2.17203575
35MP0002405_respiratory_system_inflammati2.15962022
36MP0000716_abnormal_immune_system2.13920314
37MP0000350_abnormal_cell_proliferation2.13337848
38MP0005464_abnormal_platelet_physiology2.09811105
39MP0002653_abnormal_ependyma_morphology2.06077808
40MP0009333_abnormal_splenocyte_physiolog2.01079695
41MP0002210_abnormal_sex_determination1.99903335
42MP0001929_abnormal_gametogenesis1.99188638
43MP0000689_abnormal_spleen_morphology1.96233226
44MP0003786_premature_aging1.94534138
45MP0003123_paternal_imprinting1.92141125
46MP0005395_other_phenotype1.83825588
47MP0005380_embryogenesis_phenotype1.82189496
48MP0001672_abnormal_embryogenesis/_devel1.82189496
49MP0000653_abnormal_sex_gland1.78616500
50MP0004381_abnormal_hair_follicle1.77100594
51MP0002138_abnormal_hepatobiliary_system1.74365196
52MP0002085_abnormal_embryonic_tissue1.72997633
53MP0010155_abnormal_intestine_physiology1.72318545
54MP0008007_abnormal_cellular_replicative1.72248943
55MP0001697_abnormal_embryo_size1.71289775
56MP0001145_abnormal_male_reproductive1.67531303
57MP0002084_abnormal_developmental_patter1.65704875
58MP0008260_abnormal_autophagy1.65301822
59MP0003699_abnormal_female_reproductive1.65286325
60MP0000569_abnormal_digit_pigmentation1.65112216
61MP0002429_abnormal_blood_cell1.64578871
62MP0001119_abnormal_female_reproductive1.64357896
63MP0001845_abnormal_inflammatory_respons1.63894182
64MP0005075_abnormal_melanosome_morpholog1.62500471
65MP0004133_heterotaxia1.62314463
66MP0003646_muscle_fatigue1.60048875
67MP0005310_abnormal_salivary_gland1.58866052
68MP0001873_stomach_inflammation1.58657599
69MP0001986_abnormal_taste_sensitivity1.58162617
70MP0010307_abnormal_tumor_latency1.56725665
71MP0002080_prenatal_lethality1.55008573
72MP0003183_abnormal_peptide_metabolism1.52714890
73MP0002086_abnormal_extraembryonic_tissu1.48534751
74MP0002166_altered_tumor_susceptibility1.48486460
75MP0000490_abnormal_crypts_of1.47186046
76MP0001533_abnormal_skeleton_physiology1.43075232
77MP0003866_abnormal_defecation1.42189247
78MP0009840_abnormal_foam_cell1.42068385
79MP0004264_abnormal_extraembryonic_tissu1.40345995
80MP0003315_abnormal_perineum_morphology1.39975396
81MP0003984_embryonic_growth_retardation1.39037731
82MP0000313_abnormal_cell_death1.38568447
83MP0002088_abnormal_embryonic_growth/wei1.37449461
84MP0004947_skin_inflammation1.37378330
85MP0002277_abnormal_respiratory_mucosa1.35983753
86MP0002019_abnormal_tumor_incidence1.35664041
87MP0003300_gastrointestinal_ulcer1.34472768
88MP0006292_abnormal_olfactory_placode1.32300474
89MP0003121_genomic_imprinting1.32017547
90MP0000015_abnormal_ear_pigmentation1.30590214
91MP0008469_abnormal_protein_level1.27436992
92MP0003787_abnormal_imprinting1.25428809
93MP0002161_abnormal_fertility/fecundity1.24025672
94MP0002132_abnormal_respiratory_system1.20235301
95MP0003186_abnormal_redox_activity1.17112118
96MP0001919_abnormal_reproductive_system1.16786390
97MP0003941_abnormal_skin_development1.15610994
98MP0003656_abnormal_erythrocyte_physiolo1.14683973
99MP0002006_tumorigenesis1.14109599
100MP0003890_abnormal_embryonic-extraembry1.11247690
101MP0003195_calcinosis1.09652572
102MP0005451_abnormal_body_composition1.09457403
103MP0009278_abnormal_bone_marrow1.09109781
104MP0003045_fibrosis1.08991254
105MP0004197_abnormal_fetal_growth/weight/1.08860854
106MP0009764_decreased_sensitivity_to1.07958697
107MP0005397_hematopoietic_system_phenotyp1.05260168
108MP0001545_abnormal_hematopoietic_system1.05260168
109MP0005389_reproductive_system_phenotype1.02413087
110MP0005266_abnormal_metabolism1.02347190
111MP0001293_anophthalmia1.02203604
112MP0005023_abnormal_wound_healing0.98848194
113MP0003698_abnormal_male_reproductive0.98778451
114MP0003119_abnormal_digestive_system0.96795908
115MP0003283_abnormal_digestive_organ0.96536335
116MP0001853_heart_inflammation0.95006245
117MP0002933_joint_inflammation0.92081622
118MP0005384_cellular_phenotype0.91686489
119MP0003453_abnormal_keratinocyte_physiol0.91275973
120MP0005621_abnormal_cell_physiology0.90310271
121MP0003191_abnormal_cellular_cholesterol0.89923644
122MP0002396_abnormal_hematopoietic_system0.89772240
123MP0002269_muscular_atrophy0.88409285
124MP0000358_abnormal_cell_content/0.87594321
125MP0001915_intracranial_hemorrhage0.85816765
126MP0003566_abnormal_cell_adhesion0.82371760
127MP0004883_abnormal_blood_vessel0.82047500
128MP0002998_abnormal_bone_remodeling0.81911938
129MP0003172_abnormal_lysosome_physiology0.81327958
130MP0005501_abnormal_skin_physiology0.79568337
131MP0001851_eye_inflammation0.79417233
132MP0003705_abnormal_hypodermis_morpholog0.79275090
133MP0003567_abnormal_fetal_cardiomyocyte0.76537767
134MP0002693_abnormal_pancreas_physiology0.76313820
135MP0009763_increased_sensitivity_to0.76067260
136MP0003136_yellow_coat_color0.75836293
137MP0002928_abnormal_bile_duct0.75141192
138MP0003252_abnormal_bile_duct0.75118877
139MP0002111_abnormal_tail_morphology0.73747636
140MP0000465_gastrointestinal_hemorrhage0.72540507
141MP0005174_abnormal_tail_pigmentation0.69790340
142MP0006036_abnormal_mitochondrial_physio0.69688066
143MP0006035_abnormal_mitochondrial_morpho0.69371497
144MP0008995_early_reproductive_senescence0.68196407
145MP0006072_abnormal_retinal_apoptosis0.67430581
146MP0001663_abnormal_digestive_system0.67172632
147MP0000372_irregular_coat_pigmentation0.66793262
148MP0000477_abnormal_intestine_morphology0.64425328
149MP0000858_altered_metastatic_potential0.63364993
150MP0003690_abnormal_glial_cell0.62893716
151MP0003221_abnormal_cardiomyocyte_apopto0.62630869
152MP0004142_abnormal_muscle_tone0.62547428
153MP0002796_impaired_skin_barrier0.62059022
154MP0004808_abnormal_hematopoietic_stem0.62013087
155MP0005166_decreased_susceptibility_to0.59985282
156MP0002332_abnormal_exercise_endurance0.59914275
157MP0003937_abnormal_limbs/digits/tail_de0.59522733
158MP0004185_abnormal_adipocyte_glucose0.59157998
159MP0002160_abnormal_reproductive_system0.59092719
160MP0003448_altered_tumor_morphology0.58971585
161MP0005164_abnormal_response_to0.58277924
162MP0003828_pulmonary_edema0.57952498
163MP0008961_abnormal_basal_metabolism0.57697995
164MP0004484_altered_response_of0.57025985
165MP0005410_abnormal_fertilization0.56554279
166MP0008770_decreased_survivor_rate0.55407025
167MP0001501_abnormal_sleep_pattern0.55085561
168MP0002249_abnormal_larynx_morphology0.54680094
169MP0005670_abnormal_white_adipose0.54399842
170MP0003861_abnormal_nervous_system0.53613417
171MP0002722_abnormal_immune_system0.52008619
172MP0003936_abnormal_reproductive_system0.51282381
173MP0002877_abnormal_melanocyte_morpholog0.50973784
174MP0009765_abnormal_xenobiotic_induced0.50876834
175MP0002295_abnormal_pulmonary_circulatio0.50313508
176MP0000703_abnormal_thymus_morphology0.49881136
177MP0004084_abnormal_cardiac_muscle0.49452076

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.68912226
2Breast hypoplasia (HP:0003187)5.41679171
3Stomatitis (HP:0010280)5.41192667
4Premature ovarian failure (HP:0008209)4.94203183
5T lymphocytopenia (HP:0005403)4.89702671
6Elevated erythrocyte sedimentation rate (HP:0003565)4.79618795
7Recurrent bacterial skin infections (HP:0005406)4.70094205
8Myositis (HP:0100614)4.69907662
9Retrobulbar optic neuritis (HP:0100654)4.61576733
10Optic neuritis (HP:0100653)4.61576733
11Abnormality of T cell number (HP:0011839)4.55553355
12Chromsome breakage (HP:0040012)4.51919572
13Recurrent abscess formation (HP:0002722)4.46424621
14Eczematoid dermatitis (HP:0000976)4.43796559
15Abnormality of the labia minora (HP:0012880)4.39571571
16Chromosomal breakage induced by crosslinking agents (HP:0003221)4.30480220
17Orchitis (HP:0100796)4.25585066
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.20638490
19Abnormality of macrophages (HP:0004311)4.18291163
20Ependymoma (HP:0002888)4.18233648
21Recurrent fungal infections (HP:0002841)4.15314538
22Rhabdomyosarcoma (HP:0002859)4.06952860
23Recurrent cutaneous fungal infections (HP:0011370)3.96943944
24Chronic mucocutaneous candidiasis (HP:0002728)3.96943944
25Encephalitis (HP:0002383)3.95855455
26Panhypogammaglobulinemia (HP:0003139)3.81056427
27Meningitis (HP:0001287)3.78531769
28Abnormality of T cells (HP:0002843)3.63340209
29Gastrointestinal infarctions (HP:0005244)3.63187996
30Absent radius (HP:0003974)3.61309469
31Patellar aplasia (HP:0006443)3.60858292
32Cortical dysplasia (HP:0002539)3.56032209
33Severe combined immunodeficiency (HP:0004430)3.54421310
34Recurrent skin infections (HP:0001581)3.52711684
35IgG deficiency (HP:0004315)3.52187793
36Mediastinal lymphadenopathy (HP:0100721)3.44399863
37Aplasia involving forearm bones (HP:0009822)3.39098935
38Absent forearm bone (HP:0003953)3.39098935
39Vasculitis (HP:0002633)3.37615082
40Medulloblastoma (HP:0002885)3.36762748
41Carpal bone hypoplasia (HP:0001498)3.33964049
42Aplasia/Hypoplasia of the patella (HP:0006498)3.27343535
43Meckel diverticulum (HP:0002245)3.26691240
44Impulsivity (HP:0100710)3.25523336
45Abnormality of chromosome stability (HP:0003220)3.22642574
46Bilateral sensorineural hearing impairment (HP:0008619)3.20297072
47Abnormality of the ileum (HP:0001549)3.17292893
48Neoplasm of the oral cavity (HP:0100649)3.16481795
49Keratoconjunctivitis sicca (HP:0001097)3.15976523
50Spontaneous hematomas (HP:0007420)3.13611554
51Aplasia/Hypoplasia of the uvula (HP:0010293)3.12842775
52Agnosia (HP:0010524)3.11833808
53Neoplasm of striated muscle (HP:0009728)3.11525943
54Keratoconjunctivitis (HP:0001096)3.10995072
55Obstructive lung disease (HP:0006536)3.10356586
56Chronic obstructive pulmonary disease (HP:0006510)3.10356586
57Recurrent bronchitis (HP:0002837)3.09836465
58Agammaglobulinemia (HP:0004432)3.08794069
59Absent thumb (HP:0009777)3.07720656
60Secondary amenorrhea (HP:0000869)3.07616960
61Abnormality of the preputium (HP:0100587)3.02891751
62Tetraparesis (HP:0002273)3.00119234
63Leukocytosis (HP:0001974)2.99724611
64Small intestinal stenosis (HP:0012848)2.97301621
65Duodenal stenosis (HP:0100867)2.97301621
66Recurrent viral infections (HP:0004429)2.96955145
67Cerebral hypomyelination (HP:0006808)2.96855404
68Supernumerary spleens (HP:0009799)2.95405824
69Pustule (HP:0200039)2.95214691
70Hemoptysis (HP:0002105)2.90785236
71Recurrent gram-negative bacterial infections (HP:0005420)2.89552803
72Prolonged bleeding time (HP:0003010)2.88581060
73Pulmonary infiltrates (HP:0002113)2.86177563
74Oral leukoplakia (HP:0002745)2.82815753
75Lymphopenia (HP:0001888)2.82480019
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.81556130
77Tongue fasciculations (HP:0001308)2.76258062
78Autoimmune hemolytic anemia (HP:0001890)2.76020595
79Shawl scrotum (HP:0000049)2.74959318
80Inflammation of the large intestine (HP:0002037)2.74435697
81Chest pain (HP:0100749)2.73686951
82Abnormality of eosinophils (HP:0001879)2.73271060
83Thyroiditis (HP:0100646)2.72641147
84Male infertility (HP:0003251)2.72381243
85Colon cancer (HP:0003003)2.72182284
86Heterotopia (HP:0002282)2.69916708
87Chronic diarrhea (HP:0002028)2.69562001
88Astrocytoma (HP:0009592)2.67777196
89Abnormality of the astrocytes (HP:0100707)2.67777196
90Prominent nose (HP:0000448)2.65183372
91Abnormality of T cell physiology (HP:0011840)2.63905606
92Myelodysplasia (HP:0002863)2.62983149
93Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61728028
94Glioma (HP:0009733)2.59820642
95Abnormality of B cell number (HP:0010975)2.59411376
96Triphalangeal thumb (HP:0001199)2.57584137
97Facial hemangioma (HP:0000329)2.55076249
98Gastrointestinal inflammation (HP:0004386)2.53630833
99Abnormality of cells of the lymphoid lineage (HP:0012140)2.53393800
100Pulmonary embolism (HP:0002204)2.53249657
101Hypoplasia of the thymus (HP:0000778)2.52319765
102Arterial thrombosis (HP:0004420)2.50803750
103Increased IgE level (HP:0003212)2.47128882
104Sloping forehead (HP:0000340)2.45851281
105Epistaxis (HP:0000421)2.45147699
106Granulocytopenia (HP:0001913)2.44313089
107Increased IgM level (HP:0003496)2.43832955
108Muscle fibrillation (HP:0010546)2.43651431
109Eosinophilia (HP:0001880)2.43021116
110Aplasia/Hypoplasia involving the musculature (HP:0001460)2.42885244
111Selective tooth agenesis (HP:0001592)2.41943538
112Abnormality of the duodenum (HP:0002246)2.41244647
113IgM deficiency (HP:0002850)2.39114408
114Abnormality of the salivary glands (HP:0010286)2.38268147
115Horseshoe kidney (HP:0000085)2.36317507
116Gingivitis (HP:0000230)2.36005998
117Rib fusion (HP:0000902)2.34944877
118Episodic fever (HP:0001954)2.34542598
119Bone marrow hypocellularity (HP:0005528)2.33276360
120Abnormality of the prostate (HP:0008775)2.33143788
121Anorexia (HP:0002039)2.32905719
122Gangrene (HP:0100758)2.32859008
123Aplasia/Hypoplasia of the sternum (HP:0006714)2.32322696
124Breast aplasia (HP:0100783)2.32128275
125Hypochromic microcytic anemia (HP:0004840)2.30902844
126Gingival bleeding (HP:0000225)2.30474905
127B lymphocytopenia (HP:0010976)2.28679281
128Abnormality of pyrimidine metabolism (HP:0004353)2.26955779
129Duplicated collecting system (HP:0000081)2.26279347
130Cafe-au-lait spot (HP:0000957)2.25963913
131Urticaria (HP:0001025)2.25574377
132Basal cell carcinoma (HP:0002671)2.24726460
133Acute hepatic failure (HP:0006554)2.24542126
134Ectopic kidney (HP:0000086)2.21346085
135Osteomyelitis (HP:0002754)2.20351295
136Aplasia/Hypoplasia of the breasts (HP:0010311)2.20276995
137Aplasia/hypoplasia of the humerus (HP:0006507)2.19540524
138Hypergonadotropic hypogonadism (HP:0000815)2.18515627
139Delayed puberty (HP:0000823)2.16786154
140Breech presentation (HP:0001623)2.15028846
141Recurrent sinusitis (HP:0011108)2.14741211
142Degeneration of anterior horn cells (HP:0002398)2.14583228
143Abnormality of the anterior horn cell (HP:0006802)2.14583228
144Joint swelling (HP:0001386)2.11421415
145Hypochromic anemia (HP:0001931)2.10771037
146Rectovaginal fistula (HP:0000143)2.10422628
147Rectal fistula (HP:0100590)2.10422628
148Rough bone trabeculation (HP:0100670)2.10322240
149Lymphoma (HP:0002665)2.09330068
150Short thumb (HP:0009778)2.08331479
151Colitis (HP:0002583)2.08099712
152Chronic otitis media (HP:0000389)2.07678524
153Biliary tract neoplasm (HP:0100574)2.06566447
154Gastrointestinal carcinoma (HP:0002672)2.06561226
155Malignant gastrointestinal tract tumors (HP:0006749)2.06561226
156Abnormality of the pleura (HP:0002103)2.06425767
157Stomach cancer (HP:0012126)2.05957724
158Keratitis (HP:0000491)2.04334585
159Sepsis (HP:0100806)2.01853162
160Personality changes (HP:0000751)2.00471701
161Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00193562
162Abnormality of the carotid arteries (HP:0005344)2.00114286
163Autoimmune thrombocytopenia (HP:0001973)1.99505771
164Pulmonary fibrosis (HP:0002206)1.99459428
165Polyneuropathy (HP:0001271)1.99134869
166Stenosis of the external auditory canal (HP:0000402)1.98526132
167Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98506728
168Neoplasm of the colon (HP:0100273)1.98346838
169Progressive muscle weakness (HP:0003323)1.98286941
170Verrucae (HP:0200043)1.97460305
171Papilloma (HP:0012740)1.97460305
172Squamous cell carcinoma (HP:0002860)1.95909978
173CNS hypomyelination (HP:0003429)1.95251574
174Microcytic anemia (HP:0001935)1.94482951
175Anal stenosis (HP:0002025)1.94091552
176Reticulocytopenia (HP:0001896)1.92322636
177Adrenal hypoplasia (HP:0000835)1.92074761
178Gastrointestinal stroma tumor (HP:0100723)1.90910078
179Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90191033
180Poikilocytosis (HP:0004447)1.89286559
181Short humerus (HP:0005792)1.89199272
182Skin rash (HP:0000988)1.87327409
183Neoplasm of the pancreas (HP:0002894)1.87225793
184Glomerulopathy (HP:0100820)1.86377818
185Hematochezia (HP:0002573)1.86193158
186Abnormality of chromosome segregation (HP:0002916)1.85890822
187Bronchitis (HP:0012387)1.85195457
188Aplasia/Hypoplasia of the thymus (HP:0010515)1.85129302
189Abnormality of DNA repair (HP:0003254)1.84117051
190Ureteral duplication (HP:0000073)1.83860952
191Overlapping toe (HP:0001845)1.83573173
192Papilledema (HP:0001085)1.83501056
193Alveolar cell carcinoma (HP:0006519)1.81835129
194Petechiae (HP:0000967)1.81724325
195Abnormality of the renal collecting system (HP:0004742)1.80260748
196Abnormal spermatogenesis (HP:0008669)1.79887045
197Nephroblastoma (Wilms tumor) (HP:0002667)1.77582957
198Vaginal fistula (HP:0004320)1.76386637
199Combined immunodeficiency (HP:0005387)1.76189824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTK5.11196040
2TXK4.58949996
3WEE14.14050764
4MAP4K14.10731154
5EPHA23.96941751
6EIF2AK13.62744381
7RIPK43.42554937
8BUB13.29991294
9CDC72.94680528
10FES2.64958484
11PLK42.64555009
12NEK12.59935898
13TYK22.47347142
14TNK22.44918955
15PLK12.43417100
16BLK2.42720246
17GRK62.41724532
18ZAP702.34980664
19CDK122.33182483
20NEK22.30536881
21CSK2.27537138
22CHEK22.25035321
23MAP3K132.19908905
24FRK2.17450704
25IKBKE2.15829411
26IRAK42.15039508
27RPS6KB22.13959291
28BTK2.12883115
29SYK2.06880729
30JAK32.02391326
31PNCK1.97106768
32MAP3K61.96967273
33BRAF1.88077838
34STK101.81466214
35ITK1.81390510
36TAOK31.72549595
37MAPKAPK31.72255219
38TEC1.70117531
39AKT31.67627110
40STK38L1.67119727
41EEF2K1.62633262
42MOS1.61795194
43JAK11.58018069
44HCK1.57296382
45AURKA1.54170680
46MAP3K141.54003215
47LATS21.53526707
48LCK1.52396903
49ACVR1B1.49312019
50MAP3K81.44528529
51LYN1.43931813
52AURKB1.39949528
53MARK31.38651562
54IKBKB1.38025572
55TBK11.36368163
56PLK31.34185899
57CSF1R1.34146431
58ZAK1.31378670
59SCYL21.28444431
60CDK71.27456365
61ATR1.25730870
62PIK3CG1.22894834
63BMPR21.22353327
64DYRK31.19700740
65STK41.19028798
66SIK31.17393871
67CHEK11.13469205
68MELK1.11011739
69NLK1.10904238
70SRPK11.10797449
71KIT1.10100759
72ERN11.08564583
73PRKCQ1.07470890
74PIM11.06837418
75ALK1.06339735
76CDK41.06308530
77BRSK21.05928148
78FGR1.04668046
79JAK21.04336345
80EIF2AK31.01852996
81MAP2K31.01181505
82PRKCI0.94690058
83ATM0.91836592
84CDK60.91123638
85MAP3K90.88504782
86CDK20.87763726
87ERBB40.87027055
88PRPF4B0.86882177
89NUAK10.85745885
90CAMKK20.84967653
91LATS10.83321884
92IRAK10.82424466
93EPHB10.82069506
94TAOK10.78887069
95PTK2B0.78882270
96SIK20.78384093
97STK30.78082934
98PDK10.74604718
99TESK20.73647154
100PINK10.72948406
101TSSK60.72177394
102MAPK110.71006560
103NEK60.70459722
104TLK10.69594586
105DYRK20.68647087
106ADRBK20.68132065
107CDC42BPA0.67576091
108RPS6KA40.66853230
109PASK0.66329905
110CDK10.65625372
111MAP3K30.64815486
112FGFR30.64573604
113KDR0.60891277
114CSNK1E0.60152292
115PDK30.59784796
116PDK40.59784796
117BRD40.58511430
118VRK10.57859354
119BRSK10.57501493
120PDK20.56966008
121MATK0.56081872
122GRK70.55626816
123MAP2K60.55023457
124TYRO30.54937562
125MTOR0.54832398
126TAOK20.53338540
127STK380.50192275
128MAP3K10.49842708
129PAK10.49595285
130TGFBR20.48064591
131MAPK70.47737759
132CSNK2A20.47311465
133FYN0.46139903
134CDK90.46068543
135TNIK0.45818756
136MAPK130.45740271
137MARK20.45207050
138MAP3K110.45004270
139CSNK1G10.44707151
140MAP3K70.43105072
141STK240.42948015
142BCKDK0.41034130
143CSNK2A10.40936379
144CSNK1D0.40848127
145HIPK20.40471225
146IRAK20.40060168
147TRPM70.39712613
148STK110.39609073
149DYRK1B0.38700861
150PRKDC0.36625523
151MAPK120.35799369
152YES10.35785337
153CSNK1G30.35165642
154SGK20.34970575
155CDK190.34625219
156PRKAA10.33583876
157CAMK40.32757810
158ABL10.32057972
159KSR20.30445314
160PAK40.29402298
161AKT10.28720681
162NME20.28376611
163WNK10.27885483
164GSK3B0.26395760
165EIF2AK20.26224950
166EGFR0.26144184
167MAPK140.25423215
168ICK0.24582169
169INSR0.24544179
170PRKD20.24376669
171CHUK0.24376223
172CAMKK10.24134842
173MAPK10.24046354
174RAF10.23843130
175SGK30.23533619
176ARAF0.22546481
177MST40.22051942
178MAP3K50.21755019
179STK160.21744070

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.26736968
2DNA replication_Homo sapiens_hsa030304.26334513
3Primary immunodeficiency_Homo sapiens_hsa053404.23786500
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84717120
5RNA transport_Homo sapiens_hsa030133.24661422
6Vitamin B6 metabolism_Homo sapiens_hsa007503.23324044
7Homologous recombination_Homo sapiens_hsa034403.16959007
8Graft-versus-host disease_Homo sapiens_hsa053323.15355474
9Cell cycle_Homo sapiens_hsa041103.02878631
10Allograft rejection_Homo sapiens_hsa053302.91349620
11Fanconi anemia pathway_Homo sapiens_hsa034602.88988946
12Nucleotide excision repair_Homo sapiens_hsa034202.87325798
13Autoimmune thyroid disease_Homo sapiens_hsa053202.86872719
14Base excision repair_Homo sapiens_hsa034102.85838404
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.73364441
16Proteasome_Homo sapiens_hsa030502.72000949
17RNA polymerase_Homo sapiens_hsa030202.68438876
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.68434144
19Basal transcription factors_Homo sapiens_hsa030222.62667738
20T cell receptor signaling pathway_Homo sapiens_hsa046602.53315427
21One carbon pool by folate_Homo sapiens_hsa006702.51781200
22Osteoclast differentiation_Homo sapiens_hsa043802.39707190
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38047585
24Non-homologous end-joining_Homo sapiens_hsa034502.37950709
25Spliceosome_Homo sapiens_hsa030402.33399891
26Leishmaniasis_Homo sapiens_hsa051402.31151041
27Intestinal immune network for IgA production_Homo sapiens_hsa046722.30768441
28B cell receptor signaling pathway_Homo sapiens_hsa046622.26843474
29Type I diabetes mellitus_Homo sapiens_hsa049402.22049738
30Antigen processing and presentation_Homo sapiens_hsa046122.10369981
31Hematopoietic cell lineage_Homo sapiens_hsa046402.09645135
32RNA degradation_Homo sapiens_hsa030182.07587335
33Measles_Homo sapiens_hsa051622.04523501
34NF-kappa B signaling pathway_Homo sapiens_hsa040642.00253865
35Staphylococcus aureus infection_Homo sapiens_hsa051501.99958542
36p53 signaling pathway_Homo sapiens_hsa041151.97276672
37mRNA surveillance pathway_Homo sapiens_hsa030151.90976498
38Pyrimidine metabolism_Homo sapiens_hsa002401.86675112
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.79889656
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.77275839
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72941810
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67573124
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67022270
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64240832
45Asthma_Homo sapiens_hsa053101.63853876
46Chemokine signaling pathway_Homo sapiens_hsa040621.62929014
47Ribosome_Homo sapiens_hsa030101.62481964
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.60737132
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.59018583
50Tuberculosis_Homo sapiens_hsa051521.53262749
51Oocyte meiosis_Homo sapiens_hsa041141.48272003
52Viral myocarditis_Homo sapiens_hsa054161.46062514
53Influenza A_Homo sapiens_hsa051641.39311960
54Malaria_Homo sapiens_hsa051441.30476788
55Dorso-ventral axis formation_Homo sapiens_hsa043201.28961196
56TNF signaling pathway_Homo sapiens_hsa046681.23619195
57Folate biosynthesis_Homo sapiens_hsa007901.21031833
58Regulation of autophagy_Homo sapiens_hsa041401.19506342
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.18375993
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18105164
61Toxoplasmosis_Homo sapiens_hsa051451.17475911
62Biosynthesis of amino acids_Homo sapiens_hsa012301.16854918
63Rheumatoid arthritis_Homo sapiens_hsa053231.16765896
64Platelet activation_Homo sapiens_hsa046111.13539835
65Acute myeloid leukemia_Homo sapiens_hsa052211.10451824
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09124386
67Purine metabolism_Homo sapiens_hsa002301.06924434
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03271262
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99780165
70Selenocompound metabolism_Homo sapiens_hsa004500.99722845
71Legionellosis_Homo sapiens_hsa051340.98071281
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97645987
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96757968
74Epstein-Barr virus infection_Homo sapiens_hsa051690.95094423
75Pentose phosphate pathway_Homo sapiens_hsa000300.94814755
76Hepatitis B_Homo sapiens_hsa051610.94467720
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94166997
78Non-small cell lung cancer_Homo sapiens_hsa052230.93470687
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92718332
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91360625
81Fructose and mannose metabolism_Homo sapiens_hsa000510.88407268
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83646585
83African trypanosomiasis_Homo sapiens_hsa051430.83460303
84Phagosome_Homo sapiens_hsa041450.79021148
85Hippo signaling pathway_Homo sapiens_hsa043900.78827068
86Linoleic acid metabolism_Homo sapiens_hsa005910.74607103
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70465127
88Shigellosis_Homo sapiens_hsa051310.70230102
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68597751
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.68466594
91Hepatitis C_Homo sapiens_hsa051600.65398873
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.65048643
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64557335
94Viral carcinogenesis_Homo sapiens_hsa052030.63540311
95Other glycan degradation_Homo sapiens_hsa005110.63446709
96MicroRNAs in cancer_Homo sapiens_hsa052060.61945563
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60613312
98Prolactin signaling pathway_Homo sapiens_hsa049170.58361492
99Arginine biosynthesis_Homo sapiens_hsa002200.57197278
100mTOR signaling pathway_Homo sapiens_hsa041500.56720857
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.56321409
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56131092
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.55952845
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55800403
105Pertussis_Homo sapiens_hsa051330.55353601
106Carbon metabolism_Homo sapiens_hsa012000.55022485
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.54833495
108Circadian rhythm_Homo sapiens_hsa047100.54526030
109TGF-beta signaling pathway_Homo sapiens_hsa043500.53215616
110Arginine and proline metabolism_Homo sapiens_hsa003300.53082252
111Hedgehog signaling pathway_Homo sapiens_hsa043400.51563132
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49726069
113HTLV-I infection_Homo sapiens_hsa051660.49085533
114Glutathione metabolism_Homo sapiens_hsa004800.48570633
115Olfactory transduction_Homo sapiens_hsa047400.48092223
116Ovarian steroidogenesis_Homo sapiens_hsa049130.47624014
117Sulfur relay system_Homo sapiens_hsa041220.47362388
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.45339280
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44484716
120Herpes simplex infection_Homo sapiens_hsa051680.44312571
121Galactose metabolism_Homo sapiens_hsa000520.44269049
122MAPK signaling pathway_Homo sapiens_hsa040100.43950044
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43308051
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43081687
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42326399
126VEGF signaling pathway_Homo sapiens_hsa043700.40798659
127Phototransduction_Homo sapiens_hsa047440.38004772
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.37816038
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37500106
130Choline metabolism in cancer_Homo sapiens_hsa052310.34834919
131Morphine addiction_Homo sapiens_hsa050320.34818322
132Endocytosis_Homo sapiens_hsa041440.34768285
133Arachidonic acid metabolism_Homo sapiens_hsa005900.34535027
134Renal cell carcinoma_Homo sapiens_hsa052110.34035785
135Apoptosis_Homo sapiens_hsa042100.33938542
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33624296
137Tight junction_Homo sapiens_hsa045300.33418466
138Basal cell carcinoma_Homo sapiens_hsa052170.33088435
139Insulin resistance_Homo sapiens_hsa049310.31540241
140Thyroid cancer_Homo sapiens_hsa052160.31303429
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30828780
142Ras signaling pathway_Homo sapiens_hsa040140.29865851
143Notch signaling pathway_Homo sapiens_hsa043300.29603677
144Colorectal cancer_Homo sapiens_hsa052100.29303440
145Metabolic pathways_Homo sapiens_hsa011000.28964942
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28769289
147Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28229819
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26884344
149Chronic myeloid leukemia_Homo sapiens_hsa052200.25922315
150Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24849065
151Caffeine metabolism_Homo sapiens_hsa002320.24640801
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.24095923
153Ether lipid metabolism_Homo sapiens_hsa005650.23923825
154Type II diabetes mellitus_Homo sapiens_hsa049300.23905434
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21066298
156FoxO signaling pathway_Homo sapiens_hsa040680.18682583
157Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18668908
158Inositol phosphate metabolism_Homo sapiens_hsa005620.18227592
159Huntingtons disease_Homo sapiens_hsa050160.18169117
160Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17247742
161Bladder cancer_Homo sapiens_hsa052190.16106928
162Systemic lupus erythematosus_Homo sapiens_hsa053220.14773299
163Lysine degradation_Homo sapiens_hsa003100.14487885
164Adherens junction_Homo sapiens_hsa045200.14415487
165Small cell lung cancer_Homo sapiens_hsa052220.13952949
166beta-Alanine metabolism_Homo sapiens_hsa004100.12315619
167Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12242881
168AMPK signaling pathway_Homo sapiens_hsa041520.10128053
169Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09675402
170Glycerolipid metabolism_Homo sapiens_hsa005610.09280465
171ABC transporters_Homo sapiens_hsa020100.07506493
172Pathways in cancer_Homo sapiens_hsa052000.07329696
173Pyruvate metabolism_Homo sapiens_hsa006200.06556856
174Pancreatic cancer_Homo sapiens_hsa052120.05801832
175Thyroid hormone signaling pathway_Homo sapiens_hsa049190.04704278

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