PATZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.34718288
2negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.35620784
3DNA strand elongation involved in DNA replication (GO:0006271)4.30971750
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.12317872
5DNA strand elongation (GO:0022616)4.12064278
6protein localization to kinetochore (GO:0034501)4.10808744
7regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.07906025
8negative regulation of RNA splicing (GO:0033119)4.00927773
9DNA replication initiation (GO:0006270)3.91448369
10convergent extension (GO:0060026)3.86302451
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.82914107
12telomere maintenance via semi-conservative replication (GO:0032201)3.76039736
13negative regulation of histone methylation (GO:0031061)3.73882634
14regulation of NFAT protein import into nucleus (GO:0051532)3.72206256
15negative regulation of mRNA processing (GO:0050686)3.71756211
16regulation of chromatin binding (GO:0035561)3.69176909
17protein-DNA complex disassembly (GO:0032986)3.68695956
18nucleosome disassembly (GO:0006337)3.68695956
19pre-miRNA processing (GO:0031054)3.66724143
20dosage compensation (GO:0007549)3.62870685
21ribosomal small subunit assembly (GO:0000028)3.61048372
22mitotic sister chromatid cohesion (GO:0007064)3.57907630
23protein localization to chromosome, centromeric region (GO:0071459)3.56007977
24positive regulation by host of viral transcription (GO:0043923)3.54080576
25regulation of histone H3-K9 methylation (GO:0051570)3.50933281
26DNA duplex unwinding (GO:0032508)3.50314837
27regulation of posttranscriptional gene silencing (GO:0060147)3.47481695
28regulation of gene silencing by miRNA (GO:0060964)3.47481695
29regulation of gene silencing by RNA (GO:0060966)3.47481695
30DNA replication-dependent nucleosome assembly (GO:0006335)3.47444709
31DNA replication-dependent nucleosome organization (GO:0034723)3.47444709
32DNA geometric change (GO:0032392)3.46697134
33nuclear pore organization (GO:0006999)3.40370370
34mitotic nuclear envelope disassembly (GO:0007077)3.39844040
35histone H2A acetylation (GO:0043968)3.34745239
36negative regulation of mRNA metabolic process (GO:1903312)3.27815170
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.27105239
38negative regulation of translation, ncRNA-mediated (GO:0040033)3.27105239
39regulation of translation, ncRNA-mediated (GO:0045974)3.27105239
40telomere maintenance via recombination (GO:0000722)3.26580717
41formation of translation preinitiation complex (GO:0001731)3.26300023
42mitotic chromosome condensation (GO:0007076)3.25524058
43viral transcription (GO:0019083)3.25491144
44mitotic recombination (GO:0006312)3.24515577
45regulation of sister chromatid cohesion (GO:0007063)3.23851089
46sister chromatid segregation (GO:0000819)3.23261492
47translational termination (GO:0006415)3.19247870
48ribosomal small subunit biogenesis (GO:0042274)3.19185264
49mitotic sister chromatid segregation (GO:0000070)3.19111724
50membrane disassembly (GO:0030397)3.19036254
51nuclear envelope disassembly (GO:0051081)3.19036254
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17734543
53DNA topological change (GO:0006265)3.17359923
54alternative mRNA splicing, via spliceosome (GO:0000380)3.16527141
55mRNA splicing, via spliceosome (GO:0000398)3.15868324
56RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.15868324
57mitotic metaphase plate congression (GO:0007080)3.15496479
58paraxial mesoderm development (GO:0048339)3.15409438
59translesion synthesis (GO:0019985)3.14805814
60histone H3-K36 demethylation (GO:0070544)3.13497755
61RNA splicing, via transesterification reactions (GO:0000375)3.13029199
62L-serine metabolic process (GO:0006563)3.10292475
63body morphogenesis (GO:0010171)3.09735702
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.08011000
65peptidyl-arginine omega-N-methylation (GO:0035247)3.07623861
66telomere maintenance via telomere lengthening (GO:0010833)3.07548528
67ectodermal placode formation (GO:0060788)3.05561845
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05229738
69regulation of DNA damage checkpoint (GO:2000001)3.01664277
70positive regulation of chromosome segregation (GO:0051984)3.01157252
71nuclear pore complex assembly (GO:0051292)3.00304766
72kinetochore organization (GO:0051383)2.99448120
73heterochromatin organization (GO:0070828)2.95166664
74IMP biosynthetic process (GO:0006188)2.94940007
75presynaptic membrane assembly (GO:0097105)2.94465128
76negative regulation of chromosome segregation (GO:0051985)2.94233433
77ATP-dependent chromatin remodeling (GO:0043044)2.94036541
78termination of RNA polymerase II transcription (GO:0006369)2.93939600
79maturation of SSU-rRNA (GO:0030490)2.93780429
80DNA replication checkpoint (GO:0000076)2.93160905
81metaphase plate congression (GO:0051310)2.91487062
82mRNA splice site selection (GO:0006376)2.91214360
83translational elongation (GO:0006414)2.90753459
84V(D)J recombination (GO:0033151)2.90579838
85cell migration in hindbrain (GO:0021535)2.90088743
86regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89833909
87attachment of spindle microtubules to kinetochore (GO:0008608)2.89750949
88DNA replication-independent nucleosome assembly (GO:0006336)2.88719645
89DNA replication-independent nucleosome organization (GO:0034724)2.88719645
90spindle assembly checkpoint (GO:0071173)2.88600141
91viral life cycle (GO:0019058)2.88559303
92mitotic spindle assembly checkpoint (GO:0007094)2.87784057
93translational initiation (GO:0006413)2.87606618
94negative regulation of mitotic sister chromatid separation (GO:2000816)2.86903647
95negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86903647
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86903647
97negative regulation of sister chromatid segregation (GO:0033046)2.86903647
98histone arginine methylation (GO:0034969)2.85863573
99nucleobase biosynthetic process (GO:0046112)2.85820454
100regulation of stem cell maintenance (GO:2000036)2.85533458
101chromatin assembly (GO:0031497)2.85480494
102cellular protein complex disassembly (GO:0043624)2.85398135
103chromatin assembly or disassembly (GO:0006333)2.85364102
104positive regulation of gene expression, epigenetic (GO:0045815)2.85038420
105chromatin silencing (GO:0006342)2.85014373
106IMP metabolic process (GO:0046040)2.84340721
107regulation of chromosome segregation (GO:0051983)2.83650541
108spliceosomal tri-snRNP complex assembly (GO:0000244)2.82804228
109heart valve formation (GO:0003188)2.79808637
110establishment of integrated proviral latency (GO:0075713)2.79596088
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78833738
112DNA conformation change (GO:0071103)2.78748838
113forebrain neuron differentiation (GO:0021879)2.78718031
114viral mRNA export from host cell nucleus (GO:0046784)2.78420035
115establishment of nucleus localization (GO:0040023)2.77873715
1163-UTR-mediated mRNA stabilization (GO:0070935)2.77478673
117positive regulation of histone H3-K4 methylation (GO:0051571)2.77435624
118protein localization to chromosome (GO:0034502)2.77310889
119macromolecular complex disassembly (GO:0032984)2.77134587
120embryonic retina morphogenesis in camera-type eye (GO:0060059)2.76820211
121embryonic body morphogenesis (GO:0010172)2.76695605
122neuronal stem cell maintenance (GO:0097150)2.75397755
123negative regulation of gene expression, epigenetic (GO:0045814)2.74823783
124RNA export from nucleus (GO:0006405)2.74773005
125base-excision repair (GO:0006284)2.74649053
126folic acid-containing compound biosynthetic process (GO:0009396)2.74514580
127mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.73956345
128peptidyl-arginine methylation (GO:0018216)2.73487020
129peptidyl-arginine N-methylation (GO:0035246)2.73487020
130protein complex disassembly (GO:0043241)2.71275148
131SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.71258892
132mRNA stabilization (GO:0048255)2.70963441
133RNA stabilization (GO:0043489)2.70963441
134mismatch repair (GO:0006298)2.69432462
135prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.69133984
136spliceosomal snRNP assembly (GO:0000387)2.68933472
137postreplication repair (GO:0006301)2.68330120
138kinetochore assembly (GO:0051382)2.68205134
139presynaptic membrane organization (GO:0097090)2.68098232
140positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.67989527
141positive regulation of cell cycle G2/M phase transition (GO:1902751)2.67989527
142lateral sprouting from an epithelium (GO:0060601)2.67634394
143cotranslational protein targeting to membrane (GO:0006613)2.67207384
144regulation of mammary gland epithelial cell proliferation (GO:0033599)2.65654152
145G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.64282173
146protein targeting to ER (GO:0045047)2.63984264
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.61159388
148lung-associated mesenchyme development (GO:0060484)2.60772428
149negative regulation of cell fate commitment (GO:0010454)2.60608575
150mesenchymal to epithelial transition (GO:0060231)2.59623431
151maternal placenta development (GO:0001893)2.58549410
152histone H4-K5 acetylation (GO:0043981)2.58309467
153histone H4-K8 acetylation (GO:0043982)2.58309467
154regulation of RNA export from nucleus (GO:0046831)2.56000127
155spinal cord development (GO:0021510)2.55497907
156neuron projection extension involved in neuron projection guidance (GO:1902284)2.54550936
157axon extension involved in axon guidance (GO:0048846)2.54550936
158neuron cell-cell adhesion (GO:0007158)2.53552379
159proline biosynthetic process (GO:0006561)2.52602423
160histone H4-K16 acetylation (GO:0043984)2.52494887
161embryonic camera-type eye morphogenesis (GO:0048596)2.52353076
162somatic stem cell division (GO:0048103)2.52204618
163establishment of protein localization to endoplasmic reticulum (GO:0072599)2.51531720
164tongue development (GO:0043586)2.50053363
165regulation of establishment of planar polarity (GO:0090175)2.49833552
166notochord development (GO:0030903)2.48590905
167neural tube closure (GO:0001843)2.48018650
168cellular response to cholesterol (GO:0071397)2.47562973
169protein complex localization (GO:0031503)2.47507316
170lens fiber cell development (GO:0070307)2.45830949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.28704067
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.45753390
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.60120706
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53140390
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.33239653
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12656360
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98474514
8* MYC_22102868_ChIP-Seq_BL_Human2.96350382
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70519541
10CIITA_25753668_ChIP-Seq_RAJI_Human2.48502224
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45221884
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.25483251
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.25483251
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.25483251
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24868761
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.24594774
17XRN2_22483619_ChIP-Seq_HELA_Human2.23445596
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21930078
19VDR_21846776_ChIP-Seq_THP-1_Human2.14074868
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.13377687
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02228385
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.97970547
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95904475
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.93888932
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.92860642
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.85779227
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81576232
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81075880
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78866314
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77395155
31CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77322421
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73894492
33* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72921667
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70379024
35FOXP3_21729870_ChIP-Seq_TREG_Human1.69906259
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69710279
37* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69120894
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.68792739
39* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68475780
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68012443
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67889312
42VDR_23849224_ChIP-Seq_CD4+_Human1.66943196
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66035363
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65456558
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62318562
46TTF2_22483619_ChIP-Seq_HELA_Human1.59991454
47* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59690089
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59503481
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59025213
50AR_21909140_ChIP-Seq_LNCAP_Human1.57999488
51EZH2_22144423_ChIP-Seq_EOC_Human1.57062015
52GABP_19822575_ChIP-Seq_HepG2_Human1.56942706
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54937830
54KDM2B_26808549_Chip-Seq_K562_Human1.52721195
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52364485
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52179681
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.51553109
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49763764
59SCL_19346495_ChIP-Seq_HPC-7_Human1.48745531
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47776608
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47200818
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46486318
63KDM5A_27292631_Chip-Seq_BREAST_Human1.46273473
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45628079
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45403624
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42923701
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42528430
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41146352
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39966300
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37695761
71* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36391090
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36186343
73LXR_22292898_ChIP-Seq_THP-1_Human1.35943802
74TCF7_22412390_ChIP-Seq_EML_Mouse1.34939861
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.34874429
76* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31663622
77* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31264175
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31009173
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.30940358
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30797333
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30008426
82POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29146854
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28834802
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28621977
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27807291
86NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27574774
87CREB1_26743006_Chip-Seq_LNCaP_Human1.27184905
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26979611
89* RACK7_27058665_Chip-Seq_MCF-7_Human1.26295944
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25691871
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25465718
92* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24489523
93DCP1A_22483619_ChIP-Seq_HELA_Human1.22490981
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.22116329
95* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21973349
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.20976335
97PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18391178
98* RING1B_27294783_Chip-Seq_NPCs_Mouse1.18103185
99* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17459870
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17426898
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16953194
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16808104
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15968133
104* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15824373
105UTX_26944678_Chip-Seq_JUKART_Human1.15243965
106* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15214449
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14981526
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13778572
109ISL1_27105846_Chip-Seq_CPCs_Mouse1.12460796
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12454675
111* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12412026
112KDM2B_26808549_Chip-Seq_DND41_Human1.11869935
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11159302
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10325836
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09791893
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08324132
117NANOG_16153702_ChIP-ChIP_HESCs_Human1.07847607
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06913492
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06404744
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06320887
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05401972
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05222029
123* FOXP1_21924763_ChIP-Seq_HESCs_Human1.04766420
124TFEB_21752829_ChIP-Seq_HELA_Human1.04534199
125TP53_20018659_ChIP-ChIP_R1E_Mouse1.01919392
126* MAF_26560356_Chip-Seq_TH1_Human1.01710417
127TET1_21451524_ChIP-Seq_MESCs_Mouse1.01570910
128CTCF_27219007_Chip-Seq_Bcells_Human1.01128791
129* SOX3_22085726_ChIP-Seq_NPCs_Mouse1.00880936
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00493009
131* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99329925
132* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98863803
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98415966
134* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98378086
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96004586
136* VDR_24763502_ChIP-Seq_THP-1_Human0.94695568
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94457943
138* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92666169
139ELK1_19687146_ChIP-ChIP_HELA_Human0.91687085
140ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86832633
141NOTCH1_21737748_ChIP-Seq_TLL_Human0.86127442
142* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85851341
143HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85341322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.85660550
2MP0003693_abnormal_embryo_hatching3.58512209
3MP0003111_abnormal_nucleus_morphology3.57448405
4MP0000566_synostosis3.44302456
5MP0008057_abnormal_DNA_replication3.36661289
6MP0003077_abnormal_cell_cycle3.27738776
7MP0004957_abnormal_blastocyst_morpholog3.26501560
8MP0003136_yellow_coat_color2.72815966
9MP0002396_abnormal_hematopoietic_system2.52659783
10MP0002653_abnormal_ependyma_morphology2.51005107
11MP0008058_abnormal_DNA_repair2.30310393
12MP0003123_paternal_imprinting2.30261661
13MP0008007_abnormal_cellular_replicative2.19868643
14MP0001730_embryonic_growth_arrest2.18564832
15MP0003121_genomic_imprinting2.16334088
16MP0010030_abnormal_orbit_morphology2.16134713
17MP0009278_abnormal_bone_marrow2.13941707
18MP0000350_abnormal_cell_proliferation2.12273033
19MP0004808_abnormal_hematopoietic_stem2.08387121
20MP0000778_abnormal_nervous_system2.00256044
21MP0008932_abnormal_embryonic_tissue2.00233625
22MP0008877_abnormal_DNA_methylation1.83951083
23MP0003942_abnormal_urinary_system1.82247216
24MP0002085_abnormal_embryonic_tissue1.81302979
25MP0003787_abnormal_imprinting1.78640886
26MP0010352_gastrointestinal_tract_polyps1.76764194
27MP0002084_abnormal_developmental_patter1.74319862
28MP0001346_abnormal_lacrimal_gland1.70430223
29MP0001697_abnormal_embryo_size1.69067815
30MP0001672_abnormal_embryogenesis/_devel1.67478988
31MP0005380_embryogenesis_phenotype1.67478988
32MP0005076_abnormal_cell_differentiation1.64197412
33MP0000490_abnormal_crypts_of1.60459972
34MP0000537_abnormal_urethra_morphology1.59953654
35MP0010307_abnormal_tumor_latency1.59947366
36MP0004197_abnormal_fetal_growth/weight/1.58988326
37* MP0000703_abnormal_thymus_morphology1.57870487
38MP0006292_abnormal_olfactory_placode1.57119536
39MP0001293_anophthalmia1.56794568
40MP0003567_abnormal_fetal_cardiomyocyte1.56259164
41MP0003984_embryonic_growth_retardation1.52417801
42* MP0002080_prenatal_lethality1.49149236
43MP0002088_abnormal_embryonic_growth/wei1.48597427
44MP0005377_hearing/vestibular/ear_phenot1.48525050
45MP0003878_abnormal_ear_physiology1.48525050
46MP0003763_abnormal_thymus_physiology1.46699291
47MP0003315_abnormal_perineum_morphology1.44471957
48MP0001545_abnormal_hematopoietic_system1.43714967
49MP0005397_hematopoietic_system_phenotyp1.43714967
50MP0003890_abnormal_embryonic-extraembry1.43522327
51MP0005423_abnormal_somatic_nervous1.37355989
52MP0002938_white_spotting1.36515013
53MP0000534_abnormal_ureter_morphology1.35672178
54MP0002233_abnormal_nose_morphology1.35071830
55MP0000313_abnormal_cell_death1.34807219
56MP0002086_abnormal_extraembryonic_tissu1.34142926
57MP0003122_maternal_imprinting1.29968309
58MP0000631_abnormal_neuroendocrine_gland1.29107051
59* MP0002398_abnormal_bone_marrow1.27986248
60MP0003786_premature_aging1.27711520
61MP0009379_abnormal_foot_pigmentation1.27378739
62MP0005248_abnormal_Harderian_gland1.24235054
63MP0004858_abnormal_nervous_system1.24185279
64MP0002089_abnormal_postnatal_growth/wei1.23338160
65MP0002019_abnormal_tumor_incidence1.22295256
66MP0000955_abnormal_spinal_cord1.21673376
67MP0008789_abnormal_olfactory_epithelium1.21581482
68MP0002152_abnormal_brain_morphology1.21291608
69MP0003119_abnormal_digestive_system1.19105204
70MP0003755_abnormal_palate_morphology1.17753726
71MP0002092_abnormal_eye_morphology1.14340292
72MP0004264_abnormal_extraembryonic_tissu1.14082115
73MP0001188_hyperpigmentation1.12858595
74MP0001849_ear_inflammation1.12296784
75MP0003861_abnormal_nervous_system1.11815891
76MP0002722_abnormal_immune_system1.11044635
77MP0002254_reproductive_system_inflammat1.10165334
78MP0003938_abnormal_ear_development1.09304834
79MP0000049_abnormal_middle_ear1.06783164
80MP0002081_perinatal_lethality1.06693167
81MP0000462_abnormal_digestive_system1.06251867
82MP0002822_catalepsy1.03855016
83MP0005075_abnormal_melanosome_morpholog1.03386381
84MP0000465_gastrointestinal_hemorrhage1.02849349
85MP0005174_abnormal_tail_pigmentation1.02698194
86MP0003705_abnormal_hypodermis_morpholog1.02244202
87MP0000428_abnormal_craniofacial_morphol1.01995633
88MP0005499_abnormal_olfactory_system1.01869679
89MP0005394_taste/olfaction_phenotype1.01869679
90MP0004885_abnormal_endolymph1.01615013
91MP0000432_abnormal_head_morphology1.01250918
92MP0002249_abnormal_larynx_morphology0.97635011
93MP0001340_abnormal_eyelid_morphology0.97600545
94MP0003935_abnormal_craniofacial_develop0.97581795
95MP0004742_abnormal_vestibular_system0.97354193
96* MP0000689_abnormal_spleen_morphology0.97336450
97MP0002075_abnormal_coat/hair_pigmentati0.97114397
98MP0002751_abnormal_autonomic_nervous0.96602592
99MP0000026_abnormal_inner_ear0.95641439
100MP0001286_abnormal_eye_development0.94941600
101MP0002932_abnormal_joint_morphology0.94743335
102MP0003937_abnormal_limbs/digits/tail_de0.94300182
103MP0002184_abnormal_innervation0.93960562
104MP0009333_abnormal_splenocyte_physiolog0.93685938
105MP0009703_decreased_birth_body0.93013411
106MP0000733_abnormal_muscle_development0.92822405
107MP0001529_abnormal_vocalization0.91665031
108MP0009672_abnormal_birth_weight0.91269494
109MP0008961_abnormal_basal_metabolism0.89901884
110MP0003385_abnormal_body_wall0.88345133
111MP0001485_abnormal_pinna_reflex0.86924173
112* MP0002210_abnormal_sex_determination0.85784375
113* MP0002429_abnormal_blood_cell0.85307798
114MP0002697_abnormal_eye_size0.84867872
115MP0002095_abnormal_skin_pigmentation0.83558014
116* MP0001145_abnormal_male_reproductive0.83335174
117MP0008995_early_reproductive_senescence0.82305693
118MP0004133_heterotaxia0.79985207
119MP0005367_renal/urinary_system_phenotyp0.79765722
120MP0000516_abnormal_urinary_system0.79765722
121MP0002102_abnormal_ear_morphology0.79709857
122MP0003115_abnormal_respiratory_system0.78875742
123MP0002098_abnormal_vibrissa_morphology0.78357493
124MP0002111_abnormal_tail_morphology0.78145151
125* MP0000716_abnormal_immune_system0.77252409
126MP0002114_abnormal_axial_skeleton0.76734998
127MP0000569_abnormal_digit_pigmentation0.76478762
128MP0002925_abnormal_cardiovascular_devel0.76308861
129MP0009250_abnormal_appendicular_skeleto0.76056552
130MP0008770_decreased_survivor_rate0.75813908
131MP0001915_intracranial_hemorrhage0.75226009
132MP0003283_abnormal_digestive_organ0.74791062
133MP0002116_abnormal_craniofacial_bone0.74737433
134MP0003221_abnormal_cardiomyocyte_apopto0.73867379
135MP0003943_abnormal_hepatobiliary_system0.71857843
136MP0005391_vision/eye_phenotype0.71633358
137MP0009053_abnormal_anal_canal0.70124984
138MP0006072_abnormal_retinal_apoptosis0.69870142
139MP0004233_abnormal_muscle_weight0.69342781

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.54271633
2Medulloblastoma (HP:0002885)3.50364824
3Hepatoblastoma (HP:0002884)3.41541461
4Increased nuchal translucency (HP:0010880)3.24131809
5Short 4th metacarpal (HP:0010044)3.23494805
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.23494805
7Septo-optic dysplasia (HP:0100842)3.15086291
8Volvulus (HP:0002580)3.11583740
9Hyperacusis (HP:0010780)3.02358881
10Birth length less than 3rd percentile (HP:0003561)2.97988728
11Broad distal phalanx of finger (HP:0009836)2.94099059
12Abnormality of the fingertips (HP:0001211)2.92680563
13Abnormal number of incisors (HP:0011064)2.91540575
14Partial duplication of thumb phalanx (HP:0009944)2.89932818
15Patellar aplasia (HP:0006443)2.88025527
16Reticulocytopenia (HP:0001896)2.86473168
17Colon cancer (HP:0003003)2.73555211
18Aplastic anemia (HP:0001915)2.70055187
19Selective tooth agenesis (HP:0001592)2.68443245
20Aplasia/Hypoplasia of the patella (HP:0006498)2.66987980
21Morphological abnormality of the inner ear (HP:0011390)2.65063757
22Basal cell carcinoma (HP:0002671)2.64581963
23Acute lymphatic leukemia (HP:0006721)2.63777261
24Abnormality of the astrocytes (HP:0100707)2.63240877
25Astrocytoma (HP:0009592)2.63240877
26Facial hemangioma (HP:0000329)2.62896684
27Neoplasm of the oral cavity (HP:0100649)2.59996169
28Abnormality of cells of the erythroid lineage (HP:0012130)2.57685167
29Proximal placement of thumb (HP:0009623)2.55922195
30Aplasia/Hypoplasia of the sternum (HP:0006714)2.54554415
31Renal duplication (HP:0000075)2.49970076
32Abnormality of the labia minora (HP:0012880)2.49526224
33Glioma (HP:0009733)2.48063109
34Partial duplication of the phalanx of hand (HP:0009999)2.46993511
35Abnormal number of erythroid precursors (HP:0012131)2.45422001
36Turricephaly (HP:0000262)2.42180494
37Broad thumb (HP:0011304)2.39008545
38Midline defect of the nose (HP:0004122)2.36370920
39Abnormality of the aortic arch (HP:0012303)2.36085072
40Overriding aorta (HP:0002623)2.34847831
41Neoplasm of striated muscle (HP:0009728)2.33289952
42Deviation of the thumb (HP:0009603)2.32417125
43Long eyelashes (HP:0000527)2.32146683
44Chromsome breakage (HP:0040012)2.30550551
45Esophageal atresia (HP:0002032)2.28471617
46Anophthalmia (HP:0000528)2.26189660
47Abnormality of the 4th metacarpal (HP:0010012)2.25007546
48Broad phalanges of the hand (HP:0009768)2.24612635
49Rib fusion (HP:0000902)2.24023968
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23834885
51Choanal stenosis (HP:0000452)2.23002680
52Myelodysplasia (HP:0002863)2.22753751
53Atresia of the external auditory canal (HP:0000413)2.22687659
54Vitreoretinal degeneration (HP:0000655)2.19935793
55Trigonocephaly (HP:0000243)2.18412052
56Elfin facies (HP:0004428)2.15429883
57Broad finger (HP:0001500)2.14806343
58Ectopic kidney (HP:0000086)2.14769398
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.14453526
60Prominent nose (HP:0000448)2.14173037
61Broad alveolar ridges (HP:0000187)2.13906989
62Abnormality of the anterior horn cell (HP:0006802)2.12149270
63Degeneration of anterior horn cells (HP:0002398)2.12149270
64Skin tags (HP:0010609)2.10394465
65Overlapping toe (HP:0001845)2.10002595
66Rhabdomyosarcoma (HP:0002859)2.08344601
67Bilateral microphthalmos (HP:0007633)2.07410912
68Absent septum pellucidum (HP:0001331)2.05910815
69Abnormality of cochlea (HP:0000375)2.05887863
70Abnormality of the septum pellucidum (HP:0007375)2.05178101
71Metaphyseal cupping (HP:0003021)2.04445548
72Abnormality of the parietal bone (HP:0002696)2.02388445
73Neoplasm of the pancreas (HP:0002894)2.02222329
74Arnold-Chiari malformation (HP:0002308)2.01477403
75Atrophy/Degeneration involving motor neurons (HP:0007373)2.00733330
76Absent thumb (HP:0009777)2.00233233
77Maternal diabetes (HP:0009800)1.99996994
78Cutaneous syndactyly (HP:0012725)1.98824791
79Abnormality of chromosome stability (HP:0003220)1.98069638
80Abnormality of chromosome segregation (HP:0002916)1.98047781
81Nephroblastoma (Wilms tumor) (HP:0002667)1.97270578
82Oral leukoplakia (HP:0002745)1.97115088
83Duplication of thumb phalanx (HP:0009942)1.96598868
84Impulsivity (HP:0100710)1.95553898
85Abnormality of the carotid arteries (HP:0005344)1.94217587
86Generalized hypotonia (HP:0001290)1.93478572
87Abnormality of the diencephalon (HP:0010662)1.92745565
88Preauricular skin tag (HP:0000384)1.92731694
89Optic nerve coloboma (HP:0000588)1.92339757
90Bronchomalacia (HP:0002780)1.92111829
91Neoplasm of the adrenal cortex (HP:0100641)1.91479825
92Diastasis recti (HP:0001540)1.91369962
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.90858588
94Cafe-au-lait spot (HP:0000957)1.90561041
95High anterior hairline (HP:0009890)1.90430821
96Breast hypoplasia (HP:0003187)1.90027363
97Abnormality of the ileum (HP:0001549)1.89721826
98Cerebral hypomyelination (HP:0006808)1.89595592
99Oligodactyly (HP:0012165)1.89263124
100Abnormal lung lobation (HP:0002101)1.89016548
101Obsessive-compulsive behavior (HP:0000722)1.87839577
102Abnormal sex determination (HP:0012244)1.87555562
103Sex reversal (HP:0012245)1.87555562
104Germ cell neoplasia (HP:0100728)1.87094499
105Amaurosis fugax (HP:0100576)1.86572252
106Glossoptosis (HP:0000162)1.85869767
107Cutaneous finger syndactyly (HP:0010554)1.85489713
108Tracheoesophageal fistula (HP:0002575)1.85443807
109Thin ribs (HP:0000883)1.84957729
110Cutis marmorata (HP:0000965)1.84625735
111Anal stenosis (HP:0002025)1.84339883
112Small intestinal stenosis (HP:0012848)1.84177117
113Duodenal stenosis (HP:0100867)1.84177117
114Embryonal renal neoplasm (HP:0011794)1.82837159
115Meckel diverticulum (HP:0002245)1.82518002
116Bifid scrotum (HP:0000048)1.82509903
117Myelomeningocele (HP:0002475)1.81420505
118Spina bifida occulta (HP:0003298)1.80163683
119Broad phalanx (HP:0006009)1.79477548
120Hypotelorism (HP:0000601)1.79030064
121Morphological abnormality of the middle ear (HP:0008609)1.78922685
122Megalocornea (HP:0000485)1.78744508
123Renovascular hypertension (HP:0100817)1.76642127
124Abnormality of the intervertebral disk (HP:0005108)1.76506568
125Cellular immunodeficiency (HP:0005374)1.76461790
126Omphalocele (HP:0001539)1.76172428
127Renal hypoplasia (HP:0000089)1.76070838
128Hemivertebrae (HP:0002937)1.74883811
129Pointed chin (HP:0000307)1.74771178
130Heterotopia (HP:0002282)1.74091824
131Macroorchidism (HP:0000053)1.73292153
132Abnormality of B cell number (HP:0010975)1.72750914
133B lymphocytopenia (HP:0010976)1.72750914
134Abnormality of abdominal situs (HP:0011620)1.72287239
135Abdominal situs inversus (HP:0003363)1.72287239
136Amyotrophic lateral sclerosis (HP:0007354)1.70132376
137Broad palm (HP:0001169)1.69636361
138Neoplasm of the heart (HP:0100544)1.69354591
139Asymmetry of the thorax (HP:0001555)1.68150355
140Septate vagina (HP:0001153)1.67400031
141Renal dysplasia (HP:0000110)1.67241553
142Insomnia (HP:0100785)1.67210772
14311 pairs of ribs (HP:0000878)1.64761702
144Shawl scrotum (HP:0000049)1.64728470
145Supernumerary ribs (HP:0005815)1.64048553
146Enlarged penis (HP:0000040)1.63346330
147Pendular nystagmus (HP:0012043)1.63267293
148Lymphoma (HP:0002665)1.62931694
149T lymphocytopenia (HP:0005403)1.62838806
150Flat cornea (HP:0007720)1.62828547
151Aqueductal stenosis (HP:0002410)1.62732026
152Thrombocytosis (HP:0001894)1.61950777
153Supernumerary bones of the axial skeleton (HP:0009144)1.61713704
154IgM deficiency (HP:0002850)1.61675149
155Pseudobulbar signs (HP:0002200)1.61670633
156Abnormal vertebral ossification (HP:0100569)1.61522422
157Missing ribs (HP:0000921)1.61443736
158Abnormality of the incisor (HP:0000676)1.61287303
159Embryonal neoplasm (HP:0002898)1.61045838
160Broad long bones (HP:0005622)1.58781107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.13331586
2CDC73.85683419
3SMG13.38758994
4WEE13.25958222
5MAP3K103.05731523
6CDK123.00579222
7BUB12.77127713
8PASK2.67541761
9NEK22.64032921
10SIK12.61111447
11MAPK152.27471765
12PRKD32.19580699
13DYRK32.18533614
14PKN22.12967121
15TSSK62.12214585
16RPS6KB22.06676014
17MKNK12.03719475
18TAF12.02846894
19CDK71.87909889
20ATR1.78471329
21TESK21.74657070
22SRPK11.72599479
23PNCK1.71891403
24BRD41.69215377
25CAMK1D1.68987314
26FGFR41.64039583
27CAMK1G1.63573116
28CDK41.62063862
29VRK21.59608924
30MKNK21.59247136
31TTK1.58601400
32ACVR1B1.56607779
33TGFBR11.49892164
34NTRK21.46660771
35MAP4K11.44249737
36ICK1.43327508
37PLK11.38556181
38PAK41.36838161
39TLK11.31223808
40CHEK21.28525994
41EIF2AK11.26390117
42BRSK21.25061244
43STK101.24093558
44TRIB31.22420615
45PRPF4B1.21869613
46NEK11.20140453
47AURKB1.18819925
48ALK1.18606718
49CHEK11.17564843
50KSR11.16566002
51VRK11.10209824
52BTK1.08041797
53MAP3K81.07436079
54CDK31.06553351
55STK41.05202411
56SCYL21.04988101
57MAP2K21.03243525
58TYRO31.01675737
59CDK20.99940161
60GRK60.99394360
61CCNB10.97673072
62LRRK20.97041516
63CLK10.96998185
64FLT30.95954452
65CDK60.94906518
66PLK30.93232561
67TRIM280.93037637
68BRSK10.92075263
69CSNK1G30.90687200
70UHMK10.90377469
71CDK80.88799992
72ATM0.87658987
73MTOR0.87344273
74SIK30.86085158
75HIPK20.83309732
76LATS10.82910274
77NLK0.79769794
78CASK0.74536082
79PIM10.73887062
80EPHB20.72923980
81RPS6KA40.72612866
82CDK10.72430581
83AURKA0.70146631
84MAP3K60.69025856
85PLK40.68335609
86CSNK1G10.66094531
87SIK20.64442140
88FGFR30.63164095
89PRKD20.60272579
90DYRK1A0.60234915
91MARK10.57588870
92RPS6KA20.56413753
93DYRK20.56328859
94IRAK20.56307314
95CDK190.55690407
96SGK4940.53559619
97SGK2230.53559619
98AKT20.53515171
99CDK90.52896513
100TNK20.52784745
101MAPKAPK30.52140030
102STK30.50868734
103NME10.49700981
104MAP2K40.49284549
105GSK3B0.49246223
106BMX0.48441387
107MELK0.48431286
108DYRK1B0.48229111
109CSNK2A20.47644542
110RET0.47611620
111FGFR10.47442497
112CSF1R0.47071760
113STK110.45691341
114RPS6KB10.44726047
115FGFR20.44622961
116DMPK0.44474512
117EIF2AK30.44234135
118RPS6KA50.43919396
119MAP3K90.43749484
120CSNK1G20.43713703
121MAPK80.43478249
122MAPK140.42488883
123MAP2K70.42273377
124EPHA20.41666308
125MAP3K70.41378377
126ZAP700.41375850
127RPS6KA10.40610098
128NME20.40432504
129AKT10.40381098
130MATK0.40169682
131CSNK1E0.39608560
132PRKDC0.38655589
133PAK10.38612981
134YES10.37648840
135KIT0.37576257
136PAK20.37389351
137RPS6KL10.37107266
138RPS6KC10.37107266
139MARK20.36875471
140PTK60.36798671
141ERBB20.36378191
142MAPK90.36377772
143RPS6KA60.35985722
144CDK11A0.35875756

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.52961122
2Mismatch repair_Homo sapiens_hsa034303.73322238
3Spliceosome_Homo sapiens_hsa030403.30393000
4Cell cycle_Homo sapiens_hsa041102.91092902
5Base excision repair_Homo sapiens_hsa034102.87482614
6RNA transport_Homo sapiens_hsa030132.72126351
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66471702
8Ribosome_Homo sapiens_hsa030102.38521533
9Nucleotide excision repair_Homo sapiens_hsa034202.36184988
10Homologous recombination_Homo sapiens_hsa034402.35050913
11mRNA surveillance pathway_Homo sapiens_hsa030152.25571187
12RNA polymerase_Homo sapiens_hsa030202.19531300
13Non-homologous end-joining_Homo sapiens_hsa034501.90100489
14Fanconi anemia pathway_Homo sapiens_hsa034601.76370748
15Notch signaling pathway_Homo sapiens_hsa043301.72455545
16RNA degradation_Homo sapiens_hsa030181.66374270
17Pyrimidine metabolism_Homo sapiens_hsa002401.59420687
18Basal transcription factors_Homo sapiens_hsa030221.58058035
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57319918
20Axon guidance_Homo sapiens_hsa043601.56348146
21Steroid biosynthesis_Homo sapiens_hsa001001.47818757
22One carbon pool by folate_Homo sapiens_hsa006701.47489806
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38044081
24p53 signaling pathway_Homo sapiens_hsa041151.37676873
25Basal cell carcinoma_Homo sapiens_hsa052171.37175561
26Colorectal cancer_Homo sapiens_hsa052101.35044883
27Chronic myeloid leukemia_Homo sapiens_hsa052201.34678532
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32724599
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31100686
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23795272
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23174598
32Primary immunodeficiency_Homo sapiens_hsa053401.19779092
33Oocyte meiosis_Homo sapiens_hsa041141.19731419
34Viral carcinogenesis_Homo sapiens_hsa052031.19674121
35MicroRNAs in cancer_Homo sapiens_hsa052061.19648692
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18329421
37Thyroid cancer_Homo sapiens_hsa052161.15900369
38Biosynthesis of amino acids_Homo sapiens_hsa012301.15163547
39HTLV-I infection_Homo sapiens_hsa051661.14396081
40Epstein-Barr virus infection_Homo sapiens_hsa051691.13556532
41Systemic lupus erythematosus_Homo sapiens_hsa053221.08877390
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.06775296
43Hedgehog signaling pathway_Homo sapiens_hsa043401.06184138
44Non-small cell lung cancer_Homo sapiens_hsa052231.01436771
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97632150
46Hippo signaling pathway_Homo sapiens_hsa043900.97546815
47Herpes simplex infection_Homo sapiens_hsa051680.97277540
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96618003
49Alcoholism_Homo sapiens_hsa050340.95009214
50Antigen processing and presentation_Homo sapiens_hsa046120.93019293
51Acute myeloid leukemia_Homo sapiens_hsa052210.92469668
52Choline metabolism in cancer_Homo sapiens_hsa052310.92443185
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89706715
54Small cell lung cancer_Homo sapiens_hsa052220.88212968
55mTOR signaling pathway_Homo sapiens_hsa041500.87453750
56Endometrial cancer_Homo sapiens_hsa052130.87016943
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86259257
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81759279
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80345893
60Purine metabolism_Homo sapiens_hsa002300.79907287
61Wnt signaling pathway_Homo sapiens_hsa043100.78971594
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78698459
63Proteasome_Homo sapiens_hsa030500.77463958
64B cell receptor signaling pathway_Homo sapiens_hsa046620.76932099
65Tight junction_Homo sapiens_hsa045300.75688678
66Insulin signaling pathway_Homo sapiens_hsa049100.74220086
67Pathways in cancer_Homo sapiens_hsa052000.74206389
68T cell receptor signaling pathway_Homo sapiens_hsa046600.73908011
69Hepatitis B_Homo sapiens_hsa051610.72344175
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71723877
71Pancreatic cancer_Homo sapiens_hsa052120.70657913
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70234559
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.69953458
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69767559
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67307730
76Inositol phosphate metabolism_Homo sapiens_hsa005620.65953259
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.62351940
78Shigellosis_Homo sapiens_hsa051310.61105325
79N-Glycan biosynthesis_Homo sapiens_hsa005100.59574060
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57687860
81TGF-beta signaling pathway_Homo sapiens_hsa043500.57119554
82VEGF signaling pathway_Homo sapiens_hsa043700.56936085
83Lysine degradation_Homo sapiens_hsa003100.56859999
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.56652003
85Bladder cancer_Homo sapiens_hsa052190.54032134
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53960587
87Measles_Homo sapiens_hsa051620.53532512
88Prostate cancer_Homo sapiens_hsa052150.52893813
89Renal cell carcinoma_Homo sapiens_hsa052110.52840909
90Viral myocarditis_Homo sapiens_hsa054160.51674297
91Apoptosis_Homo sapiens_hsa042100.50440246
92Rap1 signaling pathway_Homo sapiens_hsa040150.50283313
93Glioma_Homo sapiens_hsa052140.50114655
94Proteoglycans in cancer_Homo sapiens_hsa052050.50008690
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.49794602
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47952050
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.47244204
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47002356
99HIF-1 signaling pathway_Homo sapiens_hsa040660.45042773
100Adherens junction_Homo sapiens_hsa045200.43855482
101Cocaine addiction_Homo sapiens_hsa050300.43183967
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42769869
103Vitamin B6 metabolism_Homo sapiens_hsa007500.42146527
104Glucagon signaling pathway_Homo sapiens_hsa049220.41767484
105FoxO signaling pathway_Homo sapiens_hsa040680.41128627
106Gap junction_Homo sapiens_hsa045400.40203955
107ErbB signaling pathway_Homo sapiens_hsa040120.39215088
108Cholinergic synapse_Homo sapiens_hsa047250.38684645
109Prolactin signaling pathway_Homo sapiens_hsa049170.38585618
110MAPK signaling pathway_Homo sapiens_hsa040100.38434036
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34452083
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34398152
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34279252
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34272991
115Sulfur relay system_Homo sapiens_hsa041220.33995396
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33410283
117Platelet activation_Homo sapiens_hsa046110.32810139
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32763851
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32527237
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31711325
121Vitamin digestion and absorption_Homo sapiens_hsa049770.30932403
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30697825
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.30171578
124Melanogenesis_Homo sapiens_hsa049160.29975007
125Estrogen signaling pathway_Homo sapiens_hsa049150.29716807
126Hematopoietic cell lineage_Homo sapiens_hsa046400.26932636
127Melanoma_Homo sapiens_hsa052180.25920947
128Influenza A_Homo sapiens_hsa051640.25905998
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.25675728
130AMPK signaling pathway_Homo sapiens_hsa041520.25517432

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