PAWR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.35651694
2regulation of gene silencing by miRNA (GO:0060964)5.35651694
3regulation of gene silencing by RNA (GO:0060966)5.35651694
4regulation of hippo signaling (GO:0035330)4.93479377
5establishment of apical/basal cell polarity (GO:0035089)4.54708754
6paraxial mesoderm development (GO:0048339)4.40364552
7polarized epithelial cell differentiation (GO:0030859)3.90433248
8positive regulation of SMAD protein import into nucleus (GO:0060391)3.86817324
9establishment of monopolar cell polarity (GO:0061162)3.78216131
10establishment or maintenance of monopolar cell polarity (GO:0061339)3.78216131
11nuclear pore organization (GO:0006999)3.77214799
12nuclear pore complex assembly (GO:0051292)3.76630434
13intestinal epithelial cell development (GO:0060576)3.76092506
14hemidesmosome assembly (GO:0031581)3.74830544
15folic acid-containing compound biosynthetic process (GO:0009396)3.71865900
16establishment of integrated proviral latency (GO:0075713)3.68739817
17anterior/posterior axis specification, embryo (GO:0008595)3.67610974
18heterochromatin organization (GO:0070828)3.62686188
19chromatin remodeling at centromere (GO:0031055)3.61541261
20regulation of SMAD protein import into nucleus (GO:0060390)3.56333161
21epithelial cell-cell adhesion (GO:0090136)3.46978975
22regulation of centriole replication (GO:0046599)3.46821905
23regulation of translational fidelity (GO:0006450)3.45169143
24hippo signaling (GO:0035329)3.44112804
25CENP-A containing nucleosome assembly (GO:0034080)3.41805571
26trophectodermal cell differentiation (GO:0001829)3.40136712
27mitotic sister chromatid cohesion (GO:0007064)3.39388111
28protein complex localization (GO:0031503)3.35754698
29L-serine metabolic process (GO:0006563)3.31775126
30negative regulation of DNA repair (GO:0045738)3.05119557
31regulation of helicase activity (GO:0051095)3.02108579
32protein localization to chromosome, centromeric region (GO:0071459)3.01741824
33pre-miRNA processing (GO:0031054)3.01695554
34bundle of His cell to Purkinje myocyte communication (GO:0086069)2.97175583
35histone exchange (GO:0043486)2.96988785
36DNA replication checkpoint (GO:0000076)2.95448787
37formation of translation preinitiation complex (GO:0001731)2.91108746
38cellular protein complex localization (GO:0034629)2.85252111
39sister chromatid segregation (GO:0000819)2.84908658
40response to X-ray (GO:0010165)2.84625534
41regulation of centrosome cycle (GO:0046605)2.83471098
42DNA replication-independent nucleosome organization (GO:0034724)2.83013209
43DNA replication-independent nucleosome assembly (GO:0006336)2.83013209
44interferon-gamma secretion (GO:0072643)2.80654735
45metaphase plate congression (GO:0051310)2.79616207
46negative regulation of chromosome segregation (GO:0051985)2.78287618
47wound healing, spreading of epidermal cells (GO:0035313)2.77987005
48negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77917346
49negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.77917346
50negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77917346
51negative regulation of mitotic sister chromatid separation (GO:2000816)2.77917346
52negative regulation of sister chromatid segregation (GO:0033046)2.77917346
53regulation of centrosome duplication (GO:0010824)2.76652327
54DNA strand elongation involved in DNA replication (GO:0006271)2.75827062
55dorsal/ventral axis specification (GO:0009950)2.75082012
56cell fate commitment involved in formation of primary germ layer (GO:0060795)2.74846078
57notochord development (GO:0030903)2.71952680
58cell adhesion mediated by integrin (GO:0033627)2.71647301
59mitotic nuclear envelope disassembly (GO:0007077)2.71593936
60histone H2A monoubiquitination (GO:0035518)2.71022178
61spindle checkpoint (GO:0031577)2.69519817
62cell-substrate junction assembly (GO:0007044)2.69246674
63pore complex assembly (GO:0046931)2.69093432
64mitotic chromosome condensation (GO:0007076)2.68884079
65mitotic sister chromatid segregation (GO:0000070)2.67825541
66telomere maintenance via telomerase (GO:0007004)2.67309834
67tight junction assembly (GO:0070830)2.65856001
68prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.65149137
69DNA strand elongation (GO:0022616)2.64878489
70embryonic process involved in female pregnancy (GO:0060136)2.63925687
71mitotic spindle checkpoint (GO:0071174)2.61889954
72cell migration involved in sprouting angiogenesis (GO:0002042)2.61507913
73regulation of mitotic metaphase/anaphase transition (GO:0030071)2.61158010
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.61158010
75membrane disassembly (GO:0030397)2.59947459
76nuclear envelope disassembly (GO:0051081)2.59947459
77positive regulation of catenin import into nucleus (GO:0035413)2.59817131
78regulation of chromosome segregation (GO:0051983)2.59364685
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59136690
80regulation of mitotic spindle checkpoint (GO:1903504)2.59136690
81regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.58379310
82regulation of sister chromatid segregation (GO:0033045)2.58015897
83regulation of mitotic sister chromatid separation (GO:0010965)2.58015897
84regulation of mitotic sister chromatid segregation (GO:0033047)2.58015897
85DNA unwinding involved in DNA replication (GO:0006268)2.57702935
86lung-associated mesenchyme development (GO:0060484)2.57616062
87establishment of viral latency (GO:0019043)2.56968091
88DNA replication-dependent nucleosome assembly (GO:0006335)2.56040341
89DNA replication-dependent nucleosome organization (GO:0034723)2.56040341
90negative regulation of DNA-dependent DNA replication (GO:2000104)2.55165180
91basement membrane organization (GO:0071711)2.55151165
92regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.54856318
93folic acid metabolic process (GO:0046655)2.54269353
94positive regulation of endothelial cell apoptotic process (GO:2000353)2.53145532
95regulation of gene silencing (GO:0060968)2.53127346
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51683595
97regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.51206411
98desmosome organization (GO:0002934)2.51050556
99DNA geometric change (GO:0032392)2.50904351
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.49745739
101somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49745739
102negative regulation of keratinocyte proliferation (GO:0010839)2.49471740
103protein localization to kinetochore (GO:0034501)2.48092523
104regulation of nuclear cell cycle DNA replication (GO:0033262)2.47915524
105COPI coating of Golgi vesicle (GO:0048205)2.47792589
106Golgi transport vesicle coating (GO:0048200)2.47792589
107kinetochore organization (GO:0051383)2.46709425
108maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.46480515
109adherens junction assembly (GO:0034333)2.46074565
110apoptotic process involved in morphogenesis (GO:0060561)2.46015600
111regulation of cell fate specification (GO:0042659)2.45475333
112ATP-dependent chromatin remodeling (GO:0043044)2.45375694
113non-recombinational repair (GO:0000726)2.45209724
114double-strand break repair via nonhomologous end joining (GO:0006303)2.45209724
115regulation of stem cell maintenance (GO:2000036)2.44762191
116regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.44650482
117mitotic spindle assembly checkpoint (GO:0007094)2.43412611
118negative regulation of mitosis (GO:0045839)2.43342713
119positive regulation of chromosome segregation (GO:0051984)2.42570696
120branching involved in salivary gland morphogenesis (GO:0060445)2.42194447
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.42124235
122establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.41917369
123proline biosynthetic process (GO:0006561)2.41616493
124regulation of histone H3-K9 methylation (GO:0051570)2.41474689
125mitotic metaphase plate congression (GO:0007080)2.41186495
126negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.41060488
127tetrahydrofolate metabolic process (GO:0046653)2.40628326
128lateral sprouting from an epithelium (GO:0060601)2.40161333
1294-hydroxyproline metabolic process (GO:0019471)2.38667250
130maternal placenta development (GO:0001893)2.38600003
131chaperone-mediated protein complex assembly (GO:0051131)2.38376882
132endocardial cushion development (GO:0003197)2.38350243
133embryonic foregut morphogenesis (GO:0048617)2.38154129
134nucleobase biosynthetic process (GO:0046112)2.37642112
135mesodermal cell differentiation (GO:0048333)2.35087081
136chromatin assembly (GO:0031497)2.34990549
137nodal signaling pathway (GO:0038092)2.33572988
138negative regulation of cell fate specification (GO:0009996)2.33432793
139wound healing, spreading of cells (GO:0044319)2.30436745
140ribosome assembly (GO:0042255)2.29982033
141regulation of transforming growth factor beta2 production (GO:0032909)2.29142093
142gap junction assembly (GO:0016264)2.28303392
143positive regulation of hormone biosynthetic process (GO:0046886)2.26388841
144blood vessel endothelial cell migration (GO:0043534)2.26078811
145glomerular basement membrane development (GO:0032836)2.24858653
146cell migration involved in gastrulation (GO:0042074)2.24304933
147regulation of tight junction assembly (GO:2000810)2.24270789
148regulation of mitotic spindle organization (GO:0060236)2.24189026
149regulation of translational termination (GO:0006449)2.23745623
150embryonic camera-type eye development (GO:0031076)2.23383815
151glycine metabolic process (GO:0006544)2.22708017
152maturation of SSU-rRNA (GO:0030490)2.22302217
153columnar/cuboidal epithelial cell development (GO:0002066)2.22063249
154branching involved in mammary gland duct morphogenesis (GO:0060444)2.21785368
155endodermal cell differentiation (GO:0035987)2.21364690
156chondrocyte proliferation (GO:0035988)2.21319122
157IMP biosynthetic process (GO:0006188)2.21249411
158COPII vesicle coating (GO:0048208)2.20905308
159activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.19949513
160protein K6-linked ubiquitination (GO:0085020)2.18992764
161DNA duplex unwinding (GO:0032508)2.18830038
162protein retention in ER lumen (GO:0006621)2.18045324
163renal filtration (GO:0097205)2.17974065
164cellular response to vitamin D (GO:0071305)2.17407238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.01872767
2E2F7_22180533_ChIP-Seq_HELA_Human4.43265407
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.80186400
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.77646364
5POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.75443332
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.72471229
7* KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.65716075
8* KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.65716075
9* KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.65716075
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58592940
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.37500673
12TCF3_18692474_ChIP-Seq_MEFs_Mouse2.35400477
13AR_21909140_ChIP-Seq_LNCAP_Human2.34772922
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.32776808
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27033155
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.26845086
17* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19004564
18* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.18505078
19CLOCK_20551151_ChIP-Seq_293T_Human2.15420385
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.14298001
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10660211
22STAT3_1855785_ChIP-Seq_MESCs_Mouse2.06130360
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02973071
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02304795
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97475299
26ELK1_19687146_ChIP-ChIP_HELA_Human1.95483082
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93845107
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.92850514
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89583029
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88960333
31NANOG_16153702_ChIP-ChIP_HESCs_Human1.87506836
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86957417
33* EWS_26573619_Chip-Seq_HEK293_Human1.86139062
34ZNF263_19887448_ChIP-Seq_K562_Human1.86098419
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.84951936
36TCF3_18692474_ChIP-Seq_MESCs_Mouse1.84835553
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81245906
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.79045361
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78856636
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.77756759
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76416935
42* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.75762658
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.75279489
44* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75277113
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73742797
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73640386
47* FUS_26573619_Chip-Seq_HEK293_Human1.73491936
48NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.72548548
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71271448
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68449467
51* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68386294
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65681947
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.64357102
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62013374
55ATF3_27146783_Chip-Seq_COLON_Human1.61288856
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58229321
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52222412
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51768186
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48140765
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47388035
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46875258
62* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.46584911
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46144425
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41343341
65SOX2_18692474_ChIP-Seq_MEFs_Mouse1.39846786
66* GATA6_25053715_ChIP-Seq_YYC3_Human1.37449432
67TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37301886
68NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.36994508
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.36647781
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.35673438
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33598697
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31498519
73TTF2_22483619_ChIP-Seq_HELA_Human1.31341952
74* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29951128
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.29466501
76* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29303575
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28875648
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.28586427
79* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28495076
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.28070954
81* RXR_22158963_ChIP-Seq_LIVER_Mouse1.28021342
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27131368
83* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26605901
84* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26140283
85* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26140283
86TBX3_20139965_ChIP-Seq_ESCs_Mouse1.25155482
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25075792
88MYC_18940864_ChIP-ChIP_HL60_Human1.24836385
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24584643
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24435640
91NANOG_18692474_ChIP-Seq_MEFs_Mouse1.24314220
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23925619
93SOX17_20123909_ChIP-Seq_XEN_Mouse1.23757554
94* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23699466
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23430896
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23259396
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22250591
98CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22103667
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21862083
100OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20387846
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.19431364
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18514005
103* CHD1_26751641_Chip-Seq_LNCaP_Human1.18498040
104GATA4_25053715_ChIP-Seq_YYC3_Human1.17466702
105* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17066413
106SOX2_18692474_ChIP-Seq_MESCs_Mouse1.16183262
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15839794
108* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14255517
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13494634
110* RACK7_27058665_Chip-Seq_MCF-7_Human1.13102860
111XRN2_22483619_ChIP-Seq_HELA_Human1.11797836
112* E2F1_21310950_ChIP-Seq_MCF-7_Human1.11044958
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10611407
114TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10104461
115DCP1A_22483619_ChIP-Seq_HELA_Human1.09804974
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08809179
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08681684
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07926199
119LXR_22158963_ChIP-Seq_LIVER_Mouse1.06544743
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06070613
121NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06013754
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05064044
123FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03626916
124P300_19829295_ChIP-Seq_ESCs_Human1.02100405
125* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02030482
126* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01666849
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01509247
128PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00724227
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00648760
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00331982
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99583745
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98687739
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98275838
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.97993762
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96630769
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.96309899
137HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92331121
138* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91658226
139ETS1_20019798_ChIP-Seq_JURKAT_Human0.91403797
140BRD4_25478319_ChIP-Seq_HGPS_Human0.90204040
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89048278
142* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88661126
143POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87342511
144IRF1_19129219_ChIP-ChIP_H3396_Human0.83046896
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.82473440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.47823520
2MP0010352_gastrointestinal_tract_polyps3.21271917
3MP0010234_abnormal_vibrissa_follicle3.15611210
4MP0003941_abnormal_skin_development2.72188617
5MP0000537_abnormal_urethra_morphology2.62283374
6MP0003566_abnormal_cell_adhesion2.37922976
7MP0010030_abnormal_orbit_morphology2.23239225
8MP0004957_abnormal_blastocyst_morpholog2.23201988
9MP0004272_abnormal_basement_membrane2.22313184
10MP0009053_abnormal_anal_canal2.18660048
11MP0004264_abnormal_extraembryonic_tissu2.17789527
12MP0000579_abnormal_nail_morphology2.09323307
13MP0006292_abnormal_olfactory_placode2.06656400
14MP0003283_abnormal_digestive_organ2.05963073
15MP0000566_synostosis1.94966168
16MP0008438_abnormal_cutaneous_collagen1.94082257
17MP0005076_abnormal_cell_differentiation1.86857563
18MP0005623_abnormal_meninges_morphology1.84999933
19MP0003693_abnormal_embryo_hatching1.76378380
20MP0008058_abnormal_DNA_repair1.76039374
21MP0005275_abnormal_skin_tensile1.75929098
22MP0003806_abnormal_nucleotide_metabolis1.74060327
23MP0009697_abnormal_copulation1.70867014
24MP0001730_embryonic_growth_arrest1.63896954
25MP0003890_abnormal_embryonic-extraembry1.62559646
26MP0005023_abnormal_wound_healing1.58585539
27MP0002084_abnormal_developmental_patter1.56111910
28MP0003119_abnormal_digestive_system1.56003242
29MP0003718_maternal_effect1.55904207
30MP0002796_impaired_skin_barrier1.53717798
31MP0002086_abnormal_extraembryonic_tissu1.50770944
32MP0002938_white_spotting1.48497280
33MP0005380_embryogenesis_phenotype1.46354338
34MP0001672_abnormal_embryogenesis/_devel1.46354338
35MP0004197_abnormal_fetal_growth/weight/1.44487144
36MP0004133_heterotaxia1.44351440
37MP0003111_abnormal_nucleus_morphology1.43550306
38MP0001849_ear_inflammation1.40814294
39MP0003123_paternal_imprinting1.39939750
40MP0003984_embryonic_growth_retardation1.38491839
41MP0002088_abnormal_embryonic_growth/wei1.38258676
42MP0002085_abnormal_embryonic_tissue1.37250027
43MP0001697_abnormal_embryo_size1.34859437
44MP0009384_cardiac_valve_regurgitation1.34831863
45MP0002060_abnormal_skin_morphology1.33457834
46MP0003252_abnormal_bile_duct1.31337932
47MP0002139_abnormal_hepatobiliary_system1.31240636
48MP0003453_abnormal_keratinocyte_physiol1.30359635
49MP0002697_abnormal_eye_size1.29908993
50MP0003136_yellow_coat_color1.29072720
51MP0000350_abnormal_cell_proliferation1.28073954
52MP0002877_abnormal_melanocyte_morpholog1.27137883
53MP0003077_abnormal_cell_cycle1.27118256
54MP0005501_abnormal_skin_physiology1.25719748
55MP0008877_abnormal_DNA_methylation1.24324581
56MP0010678_abnormal_skin_adnexa1.22277233
57MP0005360_urolithiasis1.21563376
58MP0001299_abnormal_eye_distance/1.20605085
59MP0005367_renal/urinary_system_phenotyp1.19661805
60MP0000516_abnormal_urinary_system1.19661805
61MP0000467_abnormal_esophagus_morphology1.18075204
62MP0002254_reproductive_system_inflammat1.17632276
63MP0001293_anophthalmia1.16833952
64MP0003937_abnormal_limbs/digits/tail_de1.16801228
65MP0008932_abnormal_embryonic_tissue1.15288806
66MP0002111_abnormal_tail_morphology1.14833171
67MP0000049_abnormal_middle_ear1.13698240
68MP0000762_abnormal_tongue_morphology1.11688935
69MP0003115_abnormal_respiratory_system1.09654360
70MP0002098_abnormal_vibrissa_morphology1.09533607
71MP0002653_abnormal_ependyma_morphology1.06479294
72MP0010307_abnormal_tumor_latency1.06315079
73MP0002080_prenatal_lethality1.05384994
74MP0003567_abnormal_fetal_cardiomyocyte1.05260260
75MP0002092_abnormal_eye_morphology1.04441446
76MP0006054_spinal_hemorrhage1.03282426
77MP0005085_abnormal_gallbladder_physiolo1.01458221
78MP0010094_abnormal_chromosome_stability1.01181550
79MP0000432_abnormal_head_morphology0.99644744
80MP0004185_abnormal_adipocyte_glucose0.99373488
81MP0000462_abnormal_digestive_system0.98521024
82MP0001666_abnormal_nutrient_absorption0.97850797
83MP0000534_abnormal_ureter_morphology0.96750481
84MP0000647_abnormal_sebaceous_gland0.95624387
85MP0002160_abnormal_reproductive_system0.95136705
86MP0001188_hyperpigmentation0.94542671
87MP0000428_abnormal_craniofacial_morphol0.93970581
88MP0005220_abnormal_exocrine_pancreas0.93647858
89MP0009250_abnormal_appendicular_skeleto0.93421668
90MP0003755_abnormal_palate_morphology0.92332064
91MP0003091_abnormal_cell_migration0.92279541
92MP0009379_abnormal_foot_pigmentation0.92184754
93MP0001286_abnormal_eye_development0.91481956
94MP0003935_abnormal_craniofacial_develop0.91108177
95MP0003942_abnormal_urinary_system0.90622463
96MP0001915_intracranial_hemorrhage0.90476007
97MP0000627_abnormal_mammary_gland0.89069838
98MP0002896_abnormal_bone_mineralization0.88844220
99MP0003300_gastrointestinal_ulcer0.87338262
100MP0000427_abnormal_hair_cycle0.86858252
101MP0005257_abnormal_intraocular_pressure0.85497997
102MP0003385_abnormal_body_wall0.84397418
103MP0005365_abnormal_bile_salt0.84132937
104MP0002925_abnormal_cardiovascular_devel0.83818730
105MP0008007_abnormal_cellular_replicative0.82925676
106MP0003315_abnormal_perineum_morphology0.82644810
107MP0004019_abnormal_vitamin_homeostasis0.82611441
108MP0002233_abnormal_nose_morphology0.81725981
109MP0003861_abnormal_nervous_system0.81599067
110MP0001216_abnormal_epidermal_layer0.80972751
111MP0005508_abnormal_skeleton_morphology0.80320717
112MP0000383_abnormal_hair_follicle0.79661957
113MP0002009_preneoplasia0.78656678
114MP0010368_abnormal_lymphatic_system0.77875151
115MP0000477_abnormal_intestine_morphology0.77415420
116MP0003950_abnormal_plasma_membrane0.77089938
117MP0009703_decreased_birth_body0.76606046
118MP0000377_abnormal_hair_follicle0.76480955
119MP0003936_abnormal_reproductive_system0.75616108
120MP0001661_extended_life_span0.75042240
121MP0001340_abnormal_eyelid_morphology0.74778598
122MP0000733_abnormal_muscle_development0.73784403
123MP0002282_abnormal_trachea_morphology0.73450335
124MP0008057_abnormal_DNA_replication0.72643688
125MP0001958_emphysema0.72310721
126MP0009672_abnormal_birth_weight0.71971892
127MP0001346_abnormal_lacrimal_gland0.71938824
128MP0003943_abnormal_hepatobiliary_system0.71670066
129MP0001177_atelectasis0.71130544

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.27160056
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.17689288
3Right ventricular cardiomyopathy (HP:0011663)3.49530348
4Protrusio acetabuli (HP:0003179)3.20074420
5Missing ribs (HP:0000921)3.13598724
6Premature rupture of membranes (HP:0001788)3.03972848
7Shallow orbits (HP:0000586)2.93152187
8Meckel diverticulum (HP:0002245)2.86673841
9Selective tooth agenesis (HP:0001592)2.85534108
10Nephroblastoma (Wilms tumor) (HP:0002667)2.77881011
11Atrophic scars (HP:0001075)2.77054109
12Reticulocytopenia (HP:0001896)2.71163065
13Abnormality of chromosome stability (HP:0003220)2.69582954
14Abnormality of the ileum (HP:0001549)2.67677963
15Biliary tract neoplasm (HP:0100574)2.67058382
16Short humerus (HP:0005792)2.66611573
17Embryonal renal neoplasm (HP:0011794)2.63095718
18Ependymoma (HP:0002888)2.58559494
19Aplasia/hypoplasia of the humerus (HP:0006507)2.57175622
20Ankle contracture (HP:0006466)2.56220964
21Abnormality of monocarboxylic acid metabolism (HP:0010996)2.55121369
22Back pain (HP:0003418)2.52530525
23Bifid tongue (HP:0010297)2.50831771
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.49771264
25Focal segmental glomerulosclerosis (HP:0000097)2.49396573
26Bilateral microphthalmos (HP:0007633)2.48213999
27Stenosis of the external auditory canal (HP:0000402)2.48030956
28Cervical subluxation (HP:0003308)2.45513461
29Fused cervical vertebrae (HP:0002949)2.45090666
30Metaphyseal cupping (HP:0003021)2.43743504
31Cerebral aneurysm (HP:0004944)2.42792253
32Abnormality of the preputium (HP:0100587)2.42248772
33Ulnar bowing (HP:0003031)2.38711296
34Abnormal lung lobation (HP:0002101)2.36890347
35Spastic diplegia (HP:0001264)2.32252534
36Colon cancer (HP:0003003)2.28883072
37Septo-optic dysplasia (HP:0100842)2.25824466
38Duplication of thumb phalanx (HP:0009942)2.25155938
39Deviation of the thumb (HP:0009603)2.24925757
40Facial cleft (HP:0002006)2.24797325
41Shawl scrotum (HP:0000049)2.23895307
42Glomerulosclerosis (HP:0000096)2.22110049
43Milia (HP:0001056)2.21554125
44Small intestinal stenosis (HP:0012848)2.20329634
45Duodenal stenosis (HP:0100867)2.20329634
46Ectopic kidney (HP:0000086)2.18385539
47Abnormal hemoglobin (HP:0011902)2.16550218
48Hypoplastic labia majora (HP:0000059)2.14834140
49Trismus (HP:0000211)2.14660207
50Abnormal biliary tract morphology (HP:0012440)2.12677199
51Abnormality of the distal phalanges of the toes (HP:0010182)2.12304058
52Abnormality of the lacrimal duct (HP:0011481)2.11472097
5311 pairs of ribs (HP:0000878)2.10138152
54Malnutrition (HP:0004395)2.09837627
55Vertebral clefting (HP:0008428)2.08699813
56Triphalangeal thumb (HP:0001199)2.05907293
57Astrocytoma (HP:0009592)2.04328206
58Abnormality of the astrocytes (HP:0100707)2.04328206
59Intrahepatic cholestasis (HP:0001406)2.03499056
60Esophageal atresia (HP:0002032)2.03474351
61Birth length less than 3rd percentile (HP:0003561)2.03389856
62Hand muscle atrophy (HP:0009130)2.02091658
63Rectal prolapse (HP:0002035)2.01463496
64Gastrointestinal carcinoma (HP:0002672)2.00022704
65Malignant gastrointestinal tract tumors (HP:0006749)2.00022704
66Abnormality of the duodenum (HP:0002246)1.96803009
67Short hallux (HP:0010109)1.96683391
68Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.94966376
69Vertebral hypoplasia (HP:0008417)1.94966376
70Absent radius (HP:0003974)1.94567969
71Pterygium (HP:0001059)1.94398916
72Rhabdomyosarcoma (HP:0002859)1.92703236
73Abnormality of the calcaneus (HP:0008364)1.92629387
74Esophageal varix (HP:0002040)1.92227904
75Absent eyelashes (HP:0000561)1.91925980
76Abnormal vertebral ossification (HP:0100569)1.90397181
77Abnormality of the nasolacrimal system (HP:0000614)1.90056474
78Abnormal number of incisors (HP:0011064)1.89763141
79Onycholysis (HP:0001806)1.89421029
80Pili torti (HP:0003777)1.88850692
81Abnormality of the labia majora (HP:0012881)1.88606776
82Coronal craniosynostosis (HP:0004440)1.88217802
83Flat acetabular roof (HP:0003180)1.87191812
84Fragile nails (HP:0001808)1.86090465
85Choanal stenosis (HP:0000452)1.85749558
86Upper limb amyotrophy (HP:0009129)1.85659248
87Distal upper limb amyotrophy (HP:0007149)1.85659248
88Abnormal cartilage morphology (HP:0002763)1.85522456
89Bronchomalacia (HP:0002780)1.85513806
90Fragile skin (HP:0001030)1.85097393
91Breast carcinoma (HP:0003002)1.85085551
92Proximal placement of thumb (HP:0009623)1.84682646
93Aneurysm (HP:0002617)1.84602230
94Preaxial foot polydactyly (HP:0001841)1.84512486
95Anophthalmia (HP:0000528)1.84422887
96Abnormality of the carotid arteries (HP:0005344)1.83038672
97Turricephaly (HP:0000262)1.82690814
98Uterine neoplasm (HP:0010784)1.82089834
99Aplasia involving forearm bones (HP:0009822)1.81762750
100Absent forearm bone (HP:0003953)1.81762750
101Bowed forearm bones (HP:0003956)1.80913349
102Bowing of the arm (HP:0006488)1.80913349
103Abnormality of the nasal septum (HP:0000419)1.79992923
104Lymphangioma (HP:0100764)1.79957212
105Multiple enchondromatosis (HP:0005701)1.79621316
106Increased nuchal translucency (HP:0010880)1.78979020
107Genu recurvatum (HP:0002816)1.78378437
108Broad thumb (HP:0011304)1.78015023
109Aplasia/Hypoplasia of the hallux (HP:0008362)1.77436790
110Radial bowing (HP:0002986)1.77393387
111Absent eyebrow (HP:0002223)1.77023286
112Myelomeningocele (HP:0002475)1.76352147
113Breast hypoplasia (HP:0003187)1.75997385
114Tibial bowing (HP:0002982)1.75877460
115Hypoplasia of the pons (HP:0012110)1.72978282
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.72784590
117Cutaneous finger syndactyly (HP:0010554)1.72636420
118Synostosis of carpal bones (HP:0005048)1.72462512
119Hypoglycemic coma (HP:0001325)1.72280732
120Micronodular cirrhosis (HP:0001413)1.72015517
121Hepatoblastoma (HP:0002884)1.71801769
122Glioma (HP:0009733)1.71682596
123Aortic aneurysm (HP:0004942)1.71670752
124Cutaneous syndactyly (HP:0012725)1.71407253
125Pseudobulbar signs (HP:0002200)1.71183671
126Abnormality of the labia minora (HP:0012880)1.70727442
127Hyperglycinuria (HP:0003108)1.69242026
128Abnormality of glutamine family amino acid metabolism (HP:0010902)1.69021902
129Neoplasm of the colon (HP:0100273)1.67450503
130Increased connective tissue (HP:0009025)1.67263025
131Aplasia involving bones of the upper limbs (HP:0009823)1.66485370
132Aplasia of the phalanges of the hand (HP:0009802)1.66485370
133Aplasia involving bones of the extremities (HP:0009825)1.66485370
134Ovarian neoplasm (HP:0100615)1.66319595
135Rib fusion (HP:0000902)1.65343098
136Clubbing of toes (HP:0100760)1.64524426
137Mitral valve prolapse (HP:0001634)1.64117916
138Distal lower limb muscle weakness (HP:0009053)1.63297663
139Maternal diabetes (HP:0009800)1.62511754
140Neoplasm of the adrenal cortex (HP:0100641)1.62463212
141Woolly hair (HP:0002224)1.62083086
142Volvulus (HP:0002580)1.61319282
143Duplicated collecting system (HP:0000081)1.60621680
144Abnormality of the distal phalanx of the thumb (HP:0009617)1.60610117
145Abnormality of the pons (HP:0007361)1.60237983
146Nail dystrophy (HP:0008404)1.58553831
147Increased mean platelet volume (HP:0011877)1.58521758
148Atresia of the external auditory canal (HP:0000413)1.58407935
149Hydroxyprolinuria (HP:0003080)1.57967256
150Abnormality of proline metabolism (HP:0010907)1.57967256
151Horseshoe kidney (HP:0000085)1.57722924
152Alopecia of scalp (HP:0002293)1.57158895
153Choanal atresia (HP:0000453)1.56970292
154Unilateral renal agenesis (HP:0000122)1.56778807
155Abnormality of the septum pellucidum (HP:0007375)1.56586022
156Absent thumb (HP:0009777)1.56468167
157Vertebral fusion (HP:0002948)1.55905506
158Gout (HP:0001997)1.55897064
159Neoplasm of the rectum (HP:0100743)1.55381316
160Knee flexion contracture (HP:0006380)1.53959041
161Carpal synostosis (HP:0009702)1.53221949
162Morphological abnormality of the middle ear (HP:0008609)1.52142741
163High anterior hairline (HP:0009890)1.51972679
164Skull defect (HP:0001362)1.51493259
165Sloping forehead (HP:0000340)1.51168284
166Partial duplication of thumb phalanx (HP:0009944)1.50716705
167Hypoglycemic seizures (HP:0002173)1.48507942
168Embryonal neoplasm (HP:0002898)1.48206684
169Absent septum pellucidum (HP:0001331)1.45749196
170Microglossia (HP:0000171)1.45626511
171Aqueductal stenosis (HP:0002410)1.45507217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.52462660
2LATS13.25390042
3CDK123.02426387
4TAF12.59580203
5MKNK22.49432713
6RPS6KB22.30492631
7PKN22.29837825
8MKNK12.28650429
9STK38L2.27081779
10PBK2.10502967
11TTN1.91216077
12LATS21.87844939
13TTK1.85241912
14VRK21.81091628
15PDGFRA1.78642421
16NEK11.73152340
17TRIB31.71025959
18PTK21.70141132
19TNIK1.69650615
20DDR21.68411775
21FRK1.67923538
22EPHB21.64712009
23STK241.64058862
24WEE11.60597261
25MET1.60442930
26PAK41.57628818
27MAP3K31.56006165
28PTK61.50782912
29CDC71.50717770
30FER1.44981685
31BMPR1B1.44292017
32MST41.42990718
33STK101.41639942
34NEK21.35541123
35STK31.34894940
36PNCK1.33485869
37MTOR1.32666260
38PASK1.27442032
39EIF2AK31.23969429
40PLK41.23741910
41PAK21.23096649
42ERN11.22520631
43RIPK11.19508420
44TESK11.18384898
45MAP3K81.17647055
46LRRK21.16754369
47FLT31.14406127
48SCYL21.12374795
49PRKCI1.12255952
50CDK71.11634910
51BMX1.10420749
52MAP2K21.10137754
53BCKDK1.09782346
54MAP3K101.08502203
55ERBB41.08238503
56STK391.08001699
57EEF2K1.07971616
58AKT31.05856593
59SMG11.04262525
60BRSK21.03105336
61MAPKAPK31.03050618
62AURKB1.00720626
63FGFR10.98197973
64CDK60.95643731
65VRK10.93606796
66MAP3K20.92773276
67PLK10.92414670
68WNK40.86818782
69TGFBR10.83194689
70PIK3CA0.80481608
71OXSR10.79939717
72RPS6KA40.79425728
73PAK30.79279079
74BUB10.78925475
75TRIM280.77890619
76TIE10.75840072
77TSSK60.75790222
78CASK0.74469343
79ALK0.74445445
80PDK30.71539689
81PDK40.71539689
82NUAK10.69784264
83DYRK1B0.68837668
84CHEK10.68521371
85BRSK10.68046005
86EIF2AK20.66994301
87PLK30.65932508
88ICK0.65817732
89GRK10.65348800
90CDK40.64180880
91CHEK20.64122804
92PDK20.64041186
93AURKA0.63838688
94MAP3K90.62659110
95SIK10.62559774
96CAMK1G0.61873871
97PRKG20.61275072
98AKT20.59984935
99BRD40.59562566
100GSK3A0.58910283
101NLK0.58056910
102ERBB20.57989612
103MELK0.57789908
104MST1R0.57703990
105CSNK1E0.55403390
106DYRK30.54521771
107CSNK1G10.51196156
108PDGFRB0.48501279
109ATM0.48377068
110CDK20.47270650
111ACVR1B0.46948307
112CDK10.45210816
113SRPK10.44135441
114MYLK0.43620097
115ATR0.43588327
116PAK10.43381283
117ZAK0.43190027
118DMPK0.42334457
119WNK30.41201886
120NEK90.41113086
121BCR0.41038777
122FGFR40.40773102
123EIF2AK10.40605024
124CDK90.40566163
125CSNK1D0.40028496
126MAP2K10.39786065
127LIMK10.38991367
128CDK80.38829017
129PRKDC0.38481403
130TRPM70.38083851
131FGFR20.37059371
132PIM10.36849783
133PRKCE0.34579325
134DYRK20.34419238
135RPS6KB10.32575630
136NME10.32177934

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.38005096
2One carbon pool by folate_Homo sapiens_hsa006702.53653583
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28421276
4Hippo signaling pathway_Homo sapiens_hsa043902.16932053
5Adherens junction_Homo sapiens_hsa045202.11322414
6Selenocompound metabolism_Homo sapiens_hsa004502.07255355
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.95216393
8Fanconi anemia pathway_Homo sapiens_hsa034601.91963322
9RNA transport_Homo sapiens_hsa030131.91644259
10RNA polymerase_Homo sapiens_hsa030201.87340491
11ECM-receptor interaction_Homo sapiens_hsa045121.86946651
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.85365089
13Nitrogen metabolism_Homo sapiens_hsa009101.84422951
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83583476
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83340663
16Basal cell carcinoma_Homo sapiens_hsa052171.79021104
17Vitamin B6 metabolism_Homo sapiens_hsa007501.78251123
18Bladder cancer_Homo sapiens_hsa052191.77088511
19Tight junction_Homo sapiens_hsa045301.74050863
20Basal transcription factors_Homo sapiens_hsa030221.67394216
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.64641326
22Small cell lung cancer_Homo sapiens_hsa052221.62481964
23Mismatch repair_Homo sapiens_hsa034301.62171655
24p53 signaling pathway_Homo sapiens_hsa041151.55680565
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50578063
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50391592
27TGF-beta signaling pathway_Homo sapiens_hsa043501.45522980
28Biosynthesis of amino acids_Homo sapiens_hsa012301.43354791
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43050117
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42225206
31Cell cycle_Homo sapiens_hsa041101.37424480
32Focal adhesion_Homo sapiens_hsa045101.36468847
33Protein digestion and absorption_Homo sapiens_hsa049741.31487884
34MicroRNAs in cancer_Homo sapiens_hsa052061.30022523
35Hedgehog signaling pathway_Homo sapiens_hsa043401.29961513
36DNA replication_Homo sapiens_hsa030301.28753043
37Proteasome_Homo sapiens_hsa030501.26983605
38Proteoglycans in cancer_Homo sapiens_hsa052051.26240190
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24905984
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22331755
41Pyrimidine metabolism_Homo sapiens_hsa002401.21680435
42Folate biosynthesis_Homo sapiens_hsa007901.20821873
43Spliceosome_Homo sapiens_hsa030401.20548215
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14229391
45Glutathione metabolism_Homo sapiens_hsa004801.13709935
46Lysine degradation_Homo sapiens_hsa003101.13133731
47Arginine biosynthesis_Homo sapiens_hsa002201.12822795
48Protein export_Homo sapiens_hsa030601.11054167
49Sulfur metabolism_Homo sapiens_hsa009201.10175942
50Thyroid cancer_Homo sapiens_hsa052161.09816487
51Tryptophan metabolism_Homo sapiens_hsa003801.09100422
52Carbon metabolism_Homo sapiens_hsa012001.08559260
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07061740
54Fat digestion and absorption_Homo sapiens_hsa049751.06666523
55Propanoate metabolism_Homo sapiens_hsa006401.06396900
56Steroid biosynthesis_Homo sapiens_hsa001001.05933478
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05562966
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04653211
59Arginine and proline metabolism_Homo sapiens_hsa003301.02230017
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02179136
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01614317
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99903498
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99380660
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98394183
65mRNA surveillance pathway_Homo sapiens_hsa030150.97993983
66Nucleotide excision repair_Homo sapiens_hsa034200.96407509
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92250160
68Purine metabolism_Homo sapiens_hsa002300.90666145
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90448230
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89008786
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.88335126
72Amoebiasis_Homo sapiens_hsa051460.88003182
73Chemical carcinogenesis_Homo sapiens_hsa052040.86840994
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85011376
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.84705741
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.84341693
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80916295
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79153402
79Fructose and mannose metabolism_Homo sapiens_hsa000510.79125126
80Fatty acid degradation_Homo sapiens_hsa000710.77329746
81Viral carcinogenesis_Homo sapiens_hsa052030.76437921
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73576046
83Galactose metabolism_Homo sapiens_hsa000520.72260555
84Prostate cancer_Homo sapiens_hsa052150.71106272
85mTOR signaling pathway_Homo sapiens_hsa041500.70770964
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.70514580
87Bile secretion_Homo sapiens_hsa049760.69867220
88Vitamin digestion and absorption_Homo sapiens_hsa049770.69041685
89Pathways in cancer_Homo sapiens_hsa052000.68983645
90Retinol metabolism_Homo sapiens_hsa008300.68470239
91Melanoma_Homo sapiens_hsa052180.67029412
92Systemic lupus erythematosus_Homo sapiens_hsa053220.64450273
93Starch and sucrose metabolism_Homo sapiens_hsa005000.64375889
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63857099
95Pyruvate metabolism_Homo sapiens_hsa006200.63394545
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62866192
97Wnt signaling pathway_Homo sapiens_hsa043100.62774119
98Phenylalanine metabolism_Homo sapiens_hsa003600.60661332
99Ribosome_Homo sapiens_hsa030100.60602849
100Renin-angiotensin system_Homo sapiens_hsa046140.60023071
101HTLV-I infection_Homo sapiens_hsa051660.59744259
102Pentose phosphate pathway_Homo sapiens_hsa000300.59605902
103Oocyte meiosis_Homo sapiens_hsa041140.59242571
104Base excision repair_Homo sapiens_hsa034100.57802931
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.55557981
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53786008
107Endometrial cancer_Homo sapiens_hsa052130.52558812
108Notch signaling pathway_Homo sapiens_hsa043300.52487814
109Caffeine metabolism_Homo sapiens_hsa002320.51044206
110Homologous recombination_Homo sapiens_hsa034400.50494483
111RNA degradation_Homo sapiens_hsa030180.49774225
112N-Glycan biosynthesis_Homo sapiens_hsa005100.49649843
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47945589
114Fatty acid metabolism_Homo sapiens_hsa012120.47606933
115Chronic myeloid leukemia_Homo sapiens_hsa052200.47137354
116beta-Alanine metabolism_Homo sapiens_hsa004100.46480099
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46136587
118Mineral absorption_Homo sapiens_hsa049780.45143179
119Metabolic pathways_Homo sapiens_hsa011000.44673488
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.44098368
121Histidine metabolism_Homo sapiens_hsa003400.43544326
122Complement and coagulation cascades_Homo sapiens_hsa046100.42620113
123PPAR signaling pathway_Homo sapiens_hsa033200.41575026
124Colorectal cancer_Homo sapiens_hsa052100.41024256
125Sulfur relay system_Homo sapiens_hsa041220.36885423
126Fatty acid elongation_Homo sapiens_hsa000620.35355944
127Huntingtons disease_Homo sapiens_hsa050160.35156494
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34668481
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34533298
130Fatty acid biosynthesis_Homo sapiens_hsa000610.30009565

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