PAX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)9.81937141
2response to lipoprotein particle (GO:0055094)9.56052578
3cellular response to vitamin D (GO:0071305)9.28107649
4phosphate ion homeostasis (GO:0055062)8.49812981
5trivalent inorganic anion homeostasis (GO:0072506)8.49812981
6response to lead ion (GO:0010288)8.46797349
7virion attachment to host cell (GO:0019062)8.45047177
8adhesion of symbiont to host cell (GO:0044650)8.45047177
9cellular anion homeostasis (GO:0030002)7.94380278
10relaxation of cardiac muscle (GO:0055119)7.69438146
11response to vitamin D (GO:0033280)7.62181330
12cellular response to hepatocyte growth factor stimulus (GO:0035729)7.49189381
13response to hepatocyte growth factor (GO:0035728)7.49189381
14positive regulation of sodium ion transmembrane transporter activity (GO:2000651)7.46842823
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)6.77583756
16membrane repolarization (GO:0086009)6.77562995
17adhesion of symbiont to host (GO:0044406)6.64579711
18positive regulation of glycogen biosynthetic process (GO:0045725)6.55659810
19negative regulation of activin receptor signaling pathway (GO:0032926)6.51175635
20positive regulation of potassium ion transmembrane transporter activity (GO:1901018)6.41124430
21hemidesmosome assembly (GO:0031581)6.40852443
22collecting duct development (GO:0072044)6.37155749
23neural tube formation (GO:0001841)6.14492431
24cellular sodium ion homeostasis (GO:0006883)6.10712759
25cellular response to interferon-alpha (GO:0035457)6.07466976
26cell communication by electrical coupling (GO:0010644)5.88134427
27bundle of His cell to Purkinje myocyte communication (GO:0086069)5.84950571
28potassium ion import (GO:0010107)5.84543494
29positive regulation of glycogen metabolic process (GO:0070875)5.73648847
30mesenchymal cell differentiation involved in kidney development (GO:0072161)5.73453745
31mesenchymal cell differentiation involved in renal system development (GO:2001012)5.73453745
32positive regulation of natural killer cell differentiation (GO:0032825)5.65820599
33negative regulation of smooth muscle cell differentiation (GO:0051151)5.44432370
34potassium ion homeostasis (GO:0055075)5.32155073
35positive regulation of sodium ion transmembrane transport (GO:1902307)5.25273390
36chemosensory behavior (GO:0007635)5.05432014
37relaxation of muscle (GO:0090075)4.98314396
38detection of calcium ion (GO:0005513)4.81251367
39positive regulation of glucose import (GO:0046326)4.78629795
40skin morphogenesis (GO:0043589)4.77161262
41antigen processing and presentation of endogenous antigen (GO:0019883)4.76983495
42desmosome organization (GO:0002934)4.72529604
43negative regulation of fibroblast apoptotic process (GO:2000270)4.58039572
44regulation of glucose import in response to insulin stimulus (GO:2001273)4.52777416
45positive regulation of potassium ion transmembrane transport (GO:1901381)4.46642150
46negative regulation of microtubule polymerization (GO:0031115)4.46412012
47bone resorption (GO:0045453)4.45763663
48cytoskeletal anchoring at plasma membrane (GO:0007016)4.42854319
49regulation of cardioblast proliferation (GO:0003264)4.42582485
50regulation of secondary heart field cardioblast proliferation (GO:0003266)4.42582485
51cell communication involved in cardiac conduction (GO:0086065)4.37761217
52regulation of transforming growth factor beta2 production (GO:0032909)4.37354840
53cellular response to vitamin (GO:0071295)4.34552784
54response to interferon-alpha (GO:0035455)4.27491874
55negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.14948787
56middle ear morphogenesis (GO:0042474)4.11733723
57positive regulation of calcium ion import (GO:0090280)4.05942956
58epithelial cell fate commitment (GO:0072148)4.05799533
59regulation of glomerular filtration (GO:0003093)4.03318017
60cranial nerve morphogenesis (GO:0021602)4.02941920
61short-term memory (GO:0007614)4.01389695
62response to ischemia (GO:0002931)3.97563591
63positive regulation of glucose transport (GO:0010828)3.91797136
64positive regulation of ATP catabolic process (GO:1903291)3.90412482
65positive regulation of ATPase activity (GO:0032781)3.90412482
66regulation of somitogenesis (GO:0014807)3.88747852
67* thymus development (GO:0048538)3.87923558
68myelin maintenance (GO:0043217)3.86036204
69negative regulation of erythrocyte differentiation (GO:0045647)3.84799482
70regulation of macrophage chemotaxis (GO:0010758)3.83207411
71regulation of glucan biosynthetic process (GO:0010962)3.82323583
72regulation of glycogen biosynthetic process (GO:0005979)3.82323583
73regulation of cellular extravasation (GO:0002691)3.80722876
74extracellular matrix assembly (GO:0085029)3.74229993
75outer ear morphogenesis (GO:0042473)3.73780888
76positive regulation of bone mineralization (GO:0030501)3.69827239
77activation of MAPKKK activity (GO:0000185)3.68578435
78phosphatidylinositol dephosphorylation (GO:0046856)3.68461048
79mesenchymal cell differentiation (GO:0048762)3.67802762
80regulation of mononuclear cell migration (GO:0071675)3.66837611
81cAMP metabolic process (GO:0046058)3.64327428
82proline transport (GO:0015824)3.63798016
83cytokine production involved in immune response (GO:0002367)3.63163044
84cell differentiation involved in metanephros development (GO:0072202)3.62109097
85negative regulation of osteoblast proliferation (GO:0033689)3.59524132
86positive regulation of embryonic development (GO:0040019)3.59265564
87embryonic epithelial tube formation (GO:0001838)3.59031189
88metanephric mesenchyme development (GO:0072075)3.58203163
89negative regulation of T cell apoptotic process (GO:0070233)3.57152609
90hair follicle development (GO:0001942)3.56890252
91positive regulation of biomineral tissue development (GO:0070169)3.56193603
92lateral sprouting from an epithelium (GO:0060601)3.54914716
93cellular response to nutrient (GO:0031670)3.53711803
94regulation of natural killer cell differentiation (GO:0032823)3.53044247
95embryonic cranial skeleton morphogenesis (GO:0048701)3.52644804
96positive regulation of p38MAPK cascade (GO:1900745)3.51975863
97polyol biosynthetic process (GO:0046173)3.48777583
98regulation of hippo signaling (GO:0035330)3.48034142
99positive regulation of glucose metabolic process (GO:0010907)3.47746005
100ganglion development (GO:0061548)3.46743381
101negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.45804323
102regulation of apoptotic cell clearance (GO:2000425)3.44678280
103phospholipid dephosphorylation (GO:0046839)3.42388255
104positive regulation of potassium ion transport (GO:0043268)3.39158316
105sodium ion homeostasis (GO:0055078)3.38719394
106epithelial tube formation (GO:0072175)3.38093597
107alanine transport (GO:0032328)3.32605322
108regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.32595734
109positive regulation of Rap GTPase activity (GO:0032854)3.30800858
110kidney mesenchyme development (GO:0072074)3.28915207
111inositol phosphate-mediated signaling (GO:0048016)3.28841118
112regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.28494764
113regulation of polysaccharide biosynthetic process (GO:0032885)3.28202766
114negative regulation of leukocyte apoptotic process (GO:2000107)3.27132974
115negative regulation of biomineral tissue development (GO:0070168)3.26036657
116positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.25462605
117regulation of sodium ion transmembrane transporter activity (GO:2000649)3.24129427
118epithelial cell morphogenesis (GO:0003382)3.22896451
119renal system process involved in regulation of blood volume (GO:0001977)3.20225905
120peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.17626930
121complement activation, alternative pathway (GO:0006957)3.15141993
122positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.14532389
123positive regulation of hormone biosynthetic process (GO:0046886)3.14041843
124establishment of planar polarity (GO:0001736)3.08481123
125establishment of tissue polarity (GO:0007164)3.08481123
126muscle cell migration (GO:0014812)3.08386382
127regulation of phospholipid biosynthetic process (GO:0071071)3.06620869
128positive regulation of sodium ion transport (GO:0010765)3.05899950
129positive regulation of cellular response to insulin stimulus (GO:1900078)3.05436123
130regulation of glycogen metabolic process (GO:0070873)3.05174526
131myoblast migration (GO:0051451)3.03099722
132positive regulation of protein export from nucleus (GO:0046827)3.02768025
133regulation of Rap GTPase activity (GO:0032317)3.01129691
134gland morphogenesis (GO:0022612)3.00287422
135sequestering of extracellular ligand from receptor (GO:0035581)2.98018099
136viral genome replication (GO:0019079)2.97334137
137antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96819742
138antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.96819742
139regulation of keratinocyte proliferation (GO:0010837)2.91194782
140behavioral response to nicotine (GO:0035095)2.90038866
141regulation of fibroblast apoptotic process (GO:2000269)2.89954610
142positive regulation of mesenchymal cell proliferation (GO:0002053)2.85932017
143mesenchymal cell proliferation (GO:0010463)2.84001782
144regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.83276457
145lymphocyte homeostasis (GO:0002260)2.82183206
146cerebral cortex radially oriented cell migration (GO:0021799)2.81466605
147axon extension involved in axon guidance (GO:0048846)2.81077361
148neuron projection extension involved in neuron projection guidance (GO:1902284)2.81077361
149hair cycle process (GO:0022405)2.80757860
150molting cycle process (GO:0022404)2.80757860
151regulation of complement activation (GO:0030449)2.79890200
152cell proliferation involved in metanephros development (GO:0072203)2.78719214
153regulation of non-canonical Wnt signaling pathway (GO:2000050)2.77156589
154cell proliferation involved in kidney development (GO:0072111)2.76747188
155inositol phosphate metabolic process (GO:0043647)2.75771206
156regulation of p38MAPK cascade (GO:1900744)2.75368760
157mesenchymal to epithelial transition (GO:0060231)2.72477862
158regulation of cellular respiration (GO:0043457)2.71838657
159cell migration in hindbrain (GO:0021535)2.71645583
160regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.71580249
161regulation of polysaccharide metabolic process (GO:0032881)2.70263934
162regulation of ATPase activity (GO:0043462)2.69424792
163regulation of ATP catabolic process (GO:1903289)2.69424792
164semaphorin-plexin signaling pathway (GO:0071526)2.69256692
165receptor recycling (GO:0001881)2.68684723
166negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.68277232
167positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.68083776
168adipose tissue development (GO:0060612)2.67913278
169regulation of mesenchymal cell proliferation (GO:0010464)2.67420076
170skin development (GO:0043588)2.67364749
171planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66859787
172lymphocyte chemotaxis (GO:0048247)2.66669367
173regulation of glucose import (GO:0046324)2.66574439
174cochlea morphogenesis (GO:0090103)2.66518091
175facial nerve structural organization (GO:0021612)2.66289752
176glycine transport (GO:0015816)2.66006911
177adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.65869720
178aorta morphogenesis (GO:0035909)2.64980333
179negative regulation of lymphocyte apoptotic process (GO:0070229)2.64326783
180regulation of smooth muscle cell differentiation (GO:0051150)2.64159521
181regulation of activin receptor signaling pathway (GO:0032925)2.62926147
182G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.62074093
183regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.61464664
184respiratory system process (GO:0003016)2.60323961
185mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.58494260
186regulation of interleukin-1 secretion (GO:0050704)2.56855961
187thymic T cell selection (GO:0045061)2.55652545
188positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.55455737
189regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55176671
190non-canonical Wnt signaling pathway (GO:0035567)2.54350100
191production of molecular mediator of immune response (GO:0002440)2.54217198
192positive regulation of myoblast differentiation (GO:0045663)2.52352301
193negative regulation of keratinocyte proliferation (GO:0010839)2.52211828
194response to parathyroid hormone (GO:0071107)12.0645213
195membrane repolarization during cardiac muscle cell action potential (GO:0086013)11.3505301
196sodium ion export (GO:0071436)10.3859495
197membrane repolarization during action potential (GO:0086011)10.0311478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.97466359
2EZH2_22144423_ChIP-Seq_EOC_Human3.31451332
3GBX2_23144817_ChIP-Seq_PC3_Human3.06741473
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.02070216
5* EED_16625203_ChIP-ChIP_MESCs_Mouse2.80029240
6AR_21572438_ChIP-Seq_LNCaP_Human2.66361051
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.65842057
8NFIB_24661679_ChIP-Seq_LUNG_Mouse2.63680904
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61253085
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61253085
11* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57235884
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52184836
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43851069
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42148559
15* RNF2_27304074_Chip-Seq_ESCs_Mouse2.40606016
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39695100
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32630874
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31917977
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.18486804
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11856556
21* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.11259718
22* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04289158
23TRIM28_21343339_ChIP-Seq_HEK293_Human2.02543430
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse11.0537416
25* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.97770812
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94065296
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.93588775
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92853972
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92037060
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.90888290
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90241441
32* TP53_20018659_ChIP-ChIP_R1E_Mouse1.86859316
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85593625
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84786796
35GATA3_24758297_ChIP-Seq_MCF-7_Human1.80003888
36* CBX2_27304074_Chip-Seq_ESCs_Mouse1.78771349
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78660059
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77703001
39* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.74523967
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65714779
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.64252384
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63192472
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.52859226
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52252599
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51954374
46* RING1B_27294783_Chip-Seq_ESCs_Mouse1.46368717
47* PIAS1_25552417_ChIP-Seq_VCAP_Human1.46016960
48* RING1B_27294783_Chip-Seq_NPCs_Mouse1.45564441
49TP53_16413492_ChIP-PET_HCT116_Human1.44883471
50DROSHA_22980978_ChIP-Seq_HELA_Human1.44312547
51P300_19829295_ChIP-Seq_ESCs_Human1.43339595
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43200937
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42140783
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38672763
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38292530
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38221487
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37923810
58* RNF2_27304074_Chip-Seq_NSC_Mouse1.35722726
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33752431
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.31491290
61GF1_26923725_Chip-Seq_HPCs_Mouse1.30117885
62TP53_18474530_ChIP-ChIP_U2OS_Human1.29175600
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29126006
64* ISL1_27105846_Chip-Seq_CPCs_Mouse1.28569093
65* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28380313
66* AR_25329375_ChIP-Seq_VCAP_Human1.27656878
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26763686
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26458200
69VDR_22108803_ChIP-Seq_LS180_Human1.25953622
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25633211
71* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25606575
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24008367
73* SMAD3_21741376_ChIP-Seq_EPCs_Human1.23561297
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21749933
75* ARNT_22903824_ChIP-Seq_MCF-7_Human1.21453467
76SMAD4_21799915_ChIP-Seq_A2780_Human1.21371569
77AHR_22903824_ChIP-Seq_MCF-7_Human1.20715058
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20685881
79TAF15_26573619_Chip-Seq_HEK293_Human1.18473909
80* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17156440
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16986105
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16852035
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16086936
84FUS_26573619_Chip-Seq_HEK293_Human1.14211093
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.13652947
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.13345927
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13291280
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13041936
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.13011994
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12818224
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12466472
92ZNF274_21170338_ChIP-Seq_K562_Hela1.12142126
93STAT3_23295773_ChIP-Seq_U87_Human1.10830901
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10637869
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.10622880
96* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09640836
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07830397
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.07275272
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06698776
100AR_21909140_ChIP-Seq_LNCAP_Human1.06358263
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05995220
102* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05473466
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05311882
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03810893
105BCAT_22108803_ChIP-Seq_LS180_Human1.03206328
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.00768088
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00587452
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00056202
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99776909
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99041154
111FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98934719
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98326542
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.98067447
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97945126
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97579652
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97519065
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97519065
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97414667
119RXR_22108803_ChIP-Seq_LS180_Human0.96766530
120LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93112957
121CJUN_26792858_Chip-Seq_BT549_Human0.92464877
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92059784
123GATA1_26923725_Chip-Seq_HPCs_Mouse0.91551972
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91521989
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91251744
126RUNX2_22187159_ChIP-Seq_PCA_Human0.90542205
127* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90149516
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87946535
129CDX2_22108803_ChIP-Seq_LS180_Human0.87713290
130STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87490687
131AR_19668381_ChIP-Seq_PC3_Human0.87448917
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87307990
133TCF4_22108803_ChIP-Seq_LS180_Human0.86694097
134SOX2_20726797_ChIP-Seq_SW620_Human0.83857169
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83583343
136LXR_22158963_ChIP-Seq_LIVER_Mouse0.82384532
137TCF4_23295773_ChIP-Seq_U87_Human0.81887871
138TP63_23658742_ChIP-Seq_EP156T_Human0.81369364
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77121617
140SOX11_22085726_ChIP-Seq_ESNs_Mouse0.76492602
141SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76261169
142SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76261169
143GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.76132225
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.76069016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis7.17882165
2MP0002254_reproductive_system_inflammat7.10225775
3MP0002909_abnormal_adrenal_gland5.81738432
4MP0001346_abnormal_lacrimal_gland5.46730446
5MP0002098_abnormal_vibrissa_morphology2.89346272
6MP0003941_abnormal_skin_development2.89145388
7MP0010030_abnormal_orbit_morphology2.82486837
8MP0008789_abnormal_olfactory_epithelium2.67840086
9MP0003453_abnormal_keratinocyte_physiol2.67222684
10MP0000383_abnormal_hair_follicle2.60774172
11MP0000566_synostosis2.54681506
12MP0002234_abnormal_pharynx_morphology2.49142354
13MP0000762_abnormal_tongue_morphology2.36677920
14MP0003385_abnormal_body_wall2.20808390
15MP0000049_abnormal_middle_ear2.17807960
16MP0001849_ear_inflammation2.13972122
17MP0005623_abnormal_meninges_morphology2.10493433
18MP0001765_abnormal_ion_homeostasis2.08240941
19MP0005503_abnormal_tendon_morphology2.02867415
20MP0000467_abnormal_esophagus_morphology2.01676737
21MP0003755_abnormal_palate_morphology1.99991953
22MP0000685_abnormal_immune_system1.98872612
23MP0002177_abnormal_outer_ear1.98820805
24MP0009278_abnormal_bone_marrow1.98297479
25MP0001270_distended_abdomen1.95480187
26MP0002249_abnormal_larynx_morphology1.95265236
27MP0004484_altered_response_of1.93365276
28MP0003300_gastrointestinal_ulcer1.92003872
29MP0010678_abnormal_skin_adnexa1.89880482
30MP0002168_other_aberrant_phenotype1.88991891
31MP0002233_abnormal_nose_morphology1.88965137
32MP0002277_abnormal_respiratory_mucosa1.85923585
33MP0000678_abnormal_parathyroid_gland1.84891817
34* MP0009250_abnormal_appendicular_skeleto1.83944831
35MP0000579_abnormal_nail_morphology1.79921728
36MP0001958_emphysema1.76374190
37MP0000613_abnormal_salivary_gland1.75110497
38MP0002108_abnormal_muscle_morphology1.73123101
39MP0004215_abnormal_myocardial_fiber1.72078574
40MP0003937_abnormal_limbs/digits/tail_de1.67810657
41MP0003942_abnormal_urinary_system1.66144269
42MP0002896_abnormal_bone_mineralization1.65932793
43MP0000428_abnormal_craniofacial_morphol1.58493958
44MP0000681_abnormal_thyroid_gland1.57408655
45MP0006292_abnormal_olfactory_placode1.56091835
46MP0003935_abnormal_craniofacial_develop1.55040274
47MP0002095_abnormal_skin_pigmentation1.44638303
48MP0000538_abnormal_urinary_bladder1.43121008
49MP0001340_abnormal_eyelid_morphology1.42999257
50MP0005023_abnormal_wound_healing1.38919594
51MP0000569_abnormal_digit_pigmentation1.35716279
52MP0001348_abnormal_lacrimal_gland1.35375161
53MP0009643_abnormal_urine_homeostasis1.30182999
54* MP0002116_abnormal_craniofacial_bone1.29578485
55MP0008007_abnormal_cellular_replicative1.28156656
56MP0005248_abnormal_Harderian_gland1.27048630
57* MP0002932_abnormal_joint_morphology1.25771198
58MP0005671_abnormal_response_to1.23706313
59* MP0002938_white_spotting1.23305556
60MP0005394_taste/olfaction_phenotype1.22887228
61MP0005499_abnormal_olfactory_system1.22887228
62MP0001293_anophthalmia1.20242035
63MP0000377_abnormal_hair_follicle1.18771660
64MP0005636_abnormal_mineral_homeostasis1.17500565
65MP0000462_abnormal_digestive_system1.15770744
66MP0004272_abnormal_basement_membrane1.15467633
67MP0000537_abnormal_urethra_morphology1.14520637
68MP0008260_abnormal_autophagy1.13640700
69MP0000534_abnormal_ureter_morphology1.12346230
70MP0004019_abnormal_vitamin_homeostasis1.12173492
71MP0003183_abnormal_peptide_metabolism1.07964250
72MP0003724_increased_susceptibility_to1.07723990
73* MP0005508_abnormal_skeleton_morphology1.06863391
74MP0001835_abnormal_antigen_presentation1.06773895
75MP0003950_abnormal_plasma_membrane1.05809082
76MP0005310_abnormal_salivary_gland1.03830291
77MP0000647_abnormal_sebaceous_gland1.02798669
78* MP0002109_abnormal_limb_morphology1.01052375
79MP0002102_abnormal_ear_morphology1.00450205
80MP0003938_abnormal_ear_development1.00350306
81* MP0000163_abnormal_cartilage_morphology0.99092465
82* MP0000516_abnormal_urinary_system0.98707233
83* MP0005367_renal/urinary_system_phenotyp0.98707233
84MP0000427_abnormal_hair_cycle0.98419456
85MP0000026_abnormal_inner_ear0.97447447
86MP0004264_abnormal_extraembryonic_tissu0.96197652
87MP0000858_altered_metastatic_potential0.95603392
88MP0000432_abnormal_head_morphology0.92960710
89MP0005395_other_phenotype0.92324484
90MP0001299_abnormal_eye_distance/0.91875909
91MP0002060_abnormal_skin_morphology0.90714430
92MP0003283_abnormal_digestive_organ0.90224817
93MP0005387_immune_system_phenotype0.89530182
94MP0001790_abnormal_immune_system0.89530182
95MP0002092_abnormal_eye_morphology0.89017434
96MP0004510_myositis0.88672079
97MP0002697_abnormal_eye_size0.87217730
98MP0002876_abnormal_thyroid_physiology0.87180373
99* MP0002115_abnormal_skeleton_extremities0.85292476
100MP0002138_abnormal_hepatobiliary_system0.82873971
101MP0003303_peritoneal_inflammation0.81831517
102MP0001216_abnormal_epidermal_layer0.80102345
103MP0005166_decreased_susceptibility_to0.79448105
104MP0001851_eye_inflammation0.79245943
105MP0001177_atelectasis0.79200166
106MP0001485_abnormal_pinna_reflex0.78486774
107MP0003763_abnormal_thymus_physiology0.78454618
108MP0002796_impaired_skin_barrier0.78236344
109MP0005171_absent_coat_pigmentation0.75759669
110* MP0002111_abnormal_tail_morphology0.75224797
111MP0006072_abnormal_retinal_apoptosis0.74693863
112MP0000631_abnormal_neuroendocrine_gland0.73749688
113MP0004858_abnormal_nervous_system0.73359087
114MP0004782_abnormal_surfactant_physiolog0.72203395
115MP0001286_abnormal_eye_development0.70710084
116* MP0002114_abnormal_axial_skeleton0.70154427
117MP0002282_abnormal_trachea_morphology0.68347178
118* MP0000733_abnormal_muscle_development0.67574493
119MP0005165_increased_susceptibility_to0.67352020
120MP0002136_abnormal_kidney_physiology0.66161244
121MP0003136_yellow_coat_color0.65977757
122MP0003633_abnormal_nervous_system0.65951056
123* MP0002113_abnormal_skeleton_development0.65363061
124MP0000470_abnormal_stomach_morphology0.64721838
125MP0005193_abnormal_anterior_eye0.64603419
126MP0003638_abnormal_response/metabolism_0.64560480
127MP0009764_decreased_sensitivity_to0.62905154
128MP0005501_abnormal_skin_physiology0.62828595
129MP0002184_abnormal_innervation0.62578515
130MP0004134_abnormal_chest_morphology0.62506484
131MP0004084_abnormal_cardiac_muscle0.59265080
132* MP0005390_skeleton_phenotype0.58910061
133MP0003786_premature_aging0.58693976
134MP0008004_abnormal_stomach_pH0.58372875
135MP0003436_decreased_susceptibility_to0.57229764
136MP0003566_abnormal_cell_adhesion0.55837009
137MP0005275_abnormal_skin_tensile0.54889259
138MP0000230_abnormal_systemic_arterial0.53683371
139* MP0003795_abnormal_bone_structure0.53400448
140MP0005666_abnormal_adipose_tissue0.53079487
141MP0009840_abnormal_foam_cell0.52346132
142MP0002736_abnormal_nociception_after0.50374565
143MP0002972_abnormal_cardiac_muscle0.49781987
144MP0005620_abnormal_muscle_contractility0.49615833
145MP0003186_abnormal_redox_activity0.48533476
146MP0010234_abnormal_vibrissa_follicle0.45290937
147MP0001968_abnormal_touch/_nociception0.43423238
148MP0008775_abnormal_heart_ventricle0.43035407
149MP0001963_abnormal_hearing_physiology0.39840953
150MP0003137_abnormal_impulse_conducting0.38862450
151MP0003646_muscle_fatigue0.37685431
152MP0001486_abnormal_startle_reflex0.37422587
153MP0001915_intracranial_hemorrhage0.36526734
154MP0001191_abnormal_skin_condition0.32904455
155MP0003631_nervous_system_phenotype0.31768824
156MP0002063_abnormal_learning/memory/cond0.31728048
157MP0004036_abnormal_muscle_relaxation0.31603622
158MP0003953_abnormal_hormone_level0.31246388
159MP0002653_abnormal_ependyma_morphology0.30496117
160MP0004947_skin_inflammation0.30114116
161MP0004381_abnormal_hair_follicle0.29831217
162MP0003879_abnormal_hair_cell0.29287677
163MP0002295_abnormal_pulmonary_circulatio0.28262352
164MP0000778_abnormal_nervous_system0.27755733

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.58469837
2Hypoparathyroidism (HP:0000829)9.00319456
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.64207637
4Increased circulating renin level (HP:0000848)7.12840458
5Hypocalcemia (HP:0002901)6.63154719
6Onycholysis (HP:0001806)6.08237292
7Right ventricular cardiomyopathy (HP:0011663)6.00858146
8Milia (HP:0001056)5.88558547
9Metaphyseal irregularity (HP:0003025)5.25464626
10Atrophic scars (HP:0001075)5.20788680
11J-shaped sella turcica (HP:0002680)5.15899546
12Fragile nails (HP:0001808)5.11680714
13Conjugated hyperbilirubinemia (HP:0002908)5.03565312
14Lip pit (HP:0100267)4.83293102
15Aplasia cutis congenita (HP:0001057)4.71853085
16Vacuolated lymphocytes (HP:0001922)4.50891201
17Selective tooth agenesis (HP:0001592)4.11434497
18Plantar hyperkeratosis (HP:0007556)4.11162751
19Hyperparathyroidism (HP:0000843)4.05382496
20Natal tooth (HP:0000695)3.98590642
21Polydipsia (HP:0001959)3.70133264
22Abnormal drinking behavior (HP:0030082)3.70133264
23Chronic otitis media (HP:0000389)3.67810456
24Hypomagnesemia (HP:0002917)3.55630418
25Morphological abnormality of the middle ear (HP:0008609)3.53541460
26* Abnormality of the lacrimal duct (HP:0011481)3.47246797
27* Abnormality of the nasolacrimal system (HP:0000614)3.40875384
28Absent eyebrow (HP:0002223)3.30664284
29Pili torti (HP:0003777)3.30118588
30Fair hair (HP:0002286)3.29203932
31Shallow orbits (HP:0000586)3.12887631
32Abnormality of renin-angiotensin system (HP:0000847)3.11805076
33Esophageal atresia (HP:0002032)3.11203022
34Abnormality of magnesium homeostasis (HP:0004921)3.03961685
35Deformed sella turcica (HP:0002681)3.02463510
36Cutaneous finger syndactyly (HP:0010554)2.91473697
37Midline defect of the nose (HP:0004122)2.89724442
38Advanced eruption of teeth (HP:0006288)2.88053410
39Generalized hypopigmentation of hair (HP:0011358)2.87952557
40Hypotrichosis (HP:0001006)2.87111676
41Unilateral renal agenesis (HP:0000122)2.85286928
42Absent eyelashes (HP:0000561)2.80956972
43Abnormality of the parietal bone (HP:0002696)2.80658545
44Increased IgE level (HP:0003212)2.79516298
45* Nasolacrimal duct obstruction (HP:0000579)2.76815538
46Exotropia (HP:0000577)2.74282303
47Abnormality of renal excretion (HP:0011036)2.68173834
48Basal ganglia calcification (HP:0002135)2.68146972
49Sex reversal (HP:0012245)2.67315366
50Abnormal sex determination (HP:0012244)2.67315366
51Tachypnea (HP:0002789)2.65874374
52Nail dystrophy (HP:0008404)2.65069960
53Hypoplasia of dental enamel (HP:0006297)2.63779839
54Polyuria (HP:0000103)2.60690744
55Woolly hair (HP:0002224)2.60415333
56Sparse scalp hair (HP:0002209)2.58852392
57Amelogenesis imperfecta (HP:0000705)2.54678806
58Gonadotropin excess (HP:0000837)2.44688380
59Cutaneous syndactyly (HP:0012725)2.42456216
60Hyperphosphaturia (HP:0003109)2.39041139
61Hypokalemia (HP:0002900)2.38506880
62Oligodontia (HP:0000677)2.35185997
63Abnormality of the gastric mucosa (HP:0004295)2.33056081
64Pterygium (HP:0001059)2.29185112
65Fragile skin (HP:0001030)2.24764036
66Recurrent cutaneous fungal infections (HP:0011370)2.24701578
67Chronic mucocutaneous candidiasis (HP:0002728)2.24701578
68Hypodontia (HP:0000668)2.22863396
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20732691
70Short 4th metacarpal (HP:0010044)2.20732691
71Septo-optic dysplasia (HP:0100842)2.17761387
72Vascular calcification (HP:0004934)2.16310018
73Palmoplantar hyperkeratosis (HP:0000972)2.15911762
74Inability to walk (HP:0002540)2.14732662
75Abnormal delayed hypersensitivity skin test (HP:0002963)2.14169383
76Abnormality of permanent molar morphology (HP:0011071)2.13377663
77Abnormality of the dental root (HP:0006486)2.13377663
78Taurodontia (HP:0000679)2.13377663
79Abnormality of the sella turcica (HP:0002679)2.13078983
80Deep venous thrombosis (HP:0002625)2.12380849
81Abnormal urine output (HP:0012590)2.11831531
82Narrow nasal bridge (HP:0000446)2.11050746
83Menstrual irregularities (HP:0000858)2.11044745
84Focal motor seizures (HP:0011153)2.06193694
85Cupped ear (HP:0000378)2.05340786
86Ureteral stenosis (HP:0000071)2.05281695
87Thickened calvaria (HP:0002684)2.05055035
88Stomach cancer (HP:0012126)2.04805126
89Abnormality of molar (HP:0011077)2.04756669
90Abnormality of molar morphology (HP:0011070)2.04756669
91Microdontia (HP:0000691)2.04281465
92Palmar hyperkeratosis (HP:0010765)2.01733446
93Occipital encephalocele (HP:0002085)2.01137106
94Hypercalciuria (HP:0002150)2.00195067
95Tetany (HP:0001281)19.4409055
96Hyperphosphatemia (HP:0002905)18.0929586
97Athetosis (HP:0002305)1.98836870
98White forelock (HP:0002211)1.98700767
99Premature skin wrinkling (HP:0100678)1.98333169
100Hypoplastic labia majora (HP:0000059)1.98250503
101Abnormality of the axillary hair (HP:0100134)1.97570275
102Abnormality of secondary sexual hair (HP:0009888)1.97570275
103Nephrocalcinosis (HP:0000121)1.95908209
104Abnormal urine phosphate concentration (HP:0012599)1.95394007
105Abnormality of the dental pulp (HP:0006479)1.95024813
106Abnormality of incisor morphology (HP:0011063)1.95017785
107Abnormal hair laboratory examination (HP:0003328)1.91130593
108* Mixed hearing impairment (HP:0000410)1.89623692
109Ventricular fibrillation (HP:0001663)1.89612158
110Ulnar bowing (HP:0003031)1.88874055
111Ureteral obstruction (HP:0006000)1.87618588
112Cellular immunodeficiency (HP:0005374)1.87315278
113* Abnormality of the antihelix (HP:0009738)1.86937205
114Resting tremor (HP:0002322)1.85108510
115Cardiovascular calcification (HP:0011915)1.83636644
116Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83555943
117Absent hair (HP:0002298)1.82819107
118Abnormality of the nasal septum (HP:0000419)1.82419809
119Abnormality of potassium homeostasis (HP:0011042)1.80857784
120Conical tooth (HP:0000698)1.80130851
121Ectropion (HP:0000656)1.79890451
122Death in childhood (HP:0003819)1.79834553
123Hypophosphatemia (HP:0002148)1.79816766
124Anophthalmia (HP:0000528)1.78497648
125Everted lower lip vermilion (HP:0000232)1.78292530
126Aplasia involving bones of the extremities (HP:0009825)1.77465575
127Aplasia involving bones of the upper limbs (HP:0009823)1.77465575
128Aplasia of the phalanges of the hand (HP:0009802)1.77465575
129Sparse eyelashes (HP:0000653)1.76766876
130Myelomeningocele (HP:0002475)1.75002767
131Bilateral microphthalmos (HP:0007633)1.74576539
132Asymmetry of the thorax (HP:0001555)1.74205445
133Xerostomia (HP:0000217)1.72790124
134Panhypogammaglobulinemia (HP:0003139)1.72693528
135Recurrent corneal erosions (HP:0000495)1.72594189
136Widely spaced teeth (HP:0000687)1.72145408
137Facial cleft (HP:0002006)1.72065362
138Abnormality of the labia majora (HP:0012881)1.72005466
139Micronodular cirrhosis (HP:0001413)1.72003634
140Distal lower limb muscle weakness (HP:0009053)1.71654658
141Protruding ear (HP:0000411)1.71294320
142Skull defect (HP:0001362)1.70395477
143Renal dysplasia (HP:0000110)1.69345791
144Gastrointestinal atresia (HP:0002589)1.68378088
145Abnormality of the 4th metacarpal (HP:0010012)1.68220090
146* Alacrima (HP:0000522)1.65399057
147* Periauricular skin pits (HP:0100277)1.64764256
148* Preauricular pit (HP:0004467)1.64764256
149Scanning speech (HP:0002168)1.63953323
150Patchy hypopigmentation of hair (HP:0011365)1.62442003
151* Atresia of the external auditory canal (HP:0000413)1.61626430
152Choanal stenosis (HP:0000452)1.61219312
153Premature loss of primary teeth (HP:0006323)1.60990798
154Aplasia/Hypoplasia of the sternum (HP:0006714)1.60061615
155Dysmetric saccades (HP:0000641)1.56958601
156Congenital sensorineural hearing impairment (HP:0008527)1.53876340
157Hyperventilation (HP:0002883)1.50999675
158Aplastic anemia (HP:0001915)1.47271004
159Abnormality of intracranial pressure (HP:0012640)1.46241600
160Increased intracranial pressure (HP:0002516)1.46241600
161Hypercalcemia (HP:0003072)1.44178082
162Delayed eruption of teeth (HP:0000684)1.37898142
163Mesangial abnormality (HP:0001966)1.34794565
164Abnormality of the basal ganglia (HP:0002134)1.34032276
165Oral leukoplakia (HP:0002745)1.32964872
166Bundle branch block (HP:0011710)1.32772648
167Thin bony cortex (HP:0002753)1.28111033
168Abnormality of renal resorption (HP:0011038)1.24573946
169Enlarged epiphyses (HP:0010580)1.23480726
170Intrahepatic cholestasis (HP:0001406)1.21890468
171Tented upper lip vermilion (HP:0010804)1.19584526
172Hypotension (HP:0002615)1.18854514
173Rickets (HP:0002748)1.14853147
174Azoospermia (HP:0000027)1.14387723
175Pancreatitis (HP:0001733)1.12921247
176Hypoplasia of the iris (HP:0007676)1.12279477
177Abnormality of monocarboxylic acid metabolism (HP:0010996)1.11516054
178Abnormality of alanine metabolism (HP:0010916)1.08545033
179Hyperalaninemia (HP:0003348)1.08545033
180Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.08545033
181Genetic anticipation (HP:0003743)1.02311840
182Hypoproteinemia (HP:0003075)1.01157531
183Proximal tubulopathy (HP:0000114)1.01025385
184Intention tremor (HP:0002080)0.94394364
185Syncope (HP:0001279)0.93091298
186Central scotoma (HP:0000603)0.90605710
187Areflexia of lower limbs (HP:0002522)0.88963382
188Abnormal ciliary motility (HP:0012262)0.87789884
189Fibular aplasia (HP:0002990)0.85776339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K38.31058842
2PDK27.43085664
3MAPK157.11072139
4STK383.07890374
5TSSK63.06740434
6CASK3.06104937
7EPHA22.93977492
8LATS12.55707770
9EPHB22.33175363
10FGFR22.25820090
11RET2.13122629
12MKNK22.09858038
13PRKD32.09050423
14SMG12.03764271
15FGFR41.97636371
16EPHB11.97516239
17CDK31.92281375
18SIK11.88146284
19SIK31.85728455
20RPS6KB21.82998132
21FER1.74176543
22MAP3K121.66239114
23CDK81.66043920
24VRK11.62733588
25PRKCG1.60762771
26EPHA31.59062038
27MKNK11.57591667
28TNIK1.54136851
29BMPR1B1.51970665
30FRK1.45153349
31MAPK121.43883301
32BLK1.43560601
33TTN1.41440741
34ERBB21.40279181
35MAPK71.37891251
36TRIB31.33974803
37PINK11.32735986
38DMPK1.32697903
39MAP3K141.29951444
40AKT31.21766129
41TYK21.21595151
42NTRK21.20936014
43STK38L1.14747180
44BTK1.13995357
45PAK21.13419229
46CDC42BPA1.10369371
47EEF2K1.09979160
48RIPK11.09565010
49DYRK1A1.06831331
50MAP3K131.06636587
51PRPF4B1.03860604
52CSNK1A10.95493870
53PRKD20.93763849
54FGFR30.92658243
55JAK10.90460693
56TIE10.90420902
57IKBKE0.89417166
58MAPK40.89361442
59TGFBR10.89057714
60SGK20.88268114
61MAP2K20.87765227
62DDR20.87093025
63LATS20.87074381
64TNK20.86635826
65MAP3K10.86457416
66SGK30.86236656
67INSRR0.85855978
68PTK20.85572641
69PRKCH0.85117242
70CAMK2G0.83490167
71CLK10.83345203
72NTRK30.82494361
73HIPK20.81987316
74SIK20.80399134
75CAMK2B0.80055231
76MAPKAPK20.79420835
77ICK0.79256283
78YES10.78973253
79PIK3CA0.76497541
80PLK30.75114699
81LRRK20.72943921
82NEK60.71026825
83RIPK40.70734762
84SGK2230.70665888
85SGK4940.70665888
86MYLK0.68342630
87CAMK10.67628667
88CHUK0.66809370
89GRK10.65307570
90EIF2AK20.65290229
91JAK30.64649392
92AKT20.63963310
93KSR10.63143719
94PDPK10.62437018
95CSNK1A1L0.62026247
96PKN20.61563231
97MAPKAPK50.61457537
98MAPK130.61204026
99PRKCE0.60987929
100FES0.59574761
101TXK0.58854257
102STK30.58785479
103PTK60.56561819
104TGFBR20.56139433
105ROCK20.55626044
106CAMK40.55622976
107PDK10.54694589
108MAP3K70.54431863
109CAMK1G0.52790065
110LMTK20.52094802
111PRKD10.51790785
112ERBB30.50986780
113NUAK10.50662149
114STK390.48089259
115DYRK30.47390016
116MUSK0.46493870
117IRAK10.45055265
118MAP2K60.44852145
119ADRBK10.44289054
120NLK0.43040042
121MARK20.42834159
122ROCK10.42710549
123MST40.41507734
124CAMK2D0.41412577
125CAMK2A0.41142615
126ADRBK20.41088580
127STK240.40632303
128IKBKB0.40288776
129JAK20.40165820
130PRKCQ0.39800917
131ERN10.39392861
132ZAK0.38484333
133CSNK1D0.36036577
134MTOR0.35900249
135MAP3K60.34487509
136RPS6KA20.34364799
137MAP3K40.33971966
138PHKG10.33019521
139PHKG20.33019521
140SRPK10.32707331
141MAP2K10.32099139
142CSNK1G10.31598333
143SRC0.31129074
144ILK0.31066764
145PNCK0.30444845
146EPHA40.29675199
147PASK0.29199537
148MAP2K70.28915149
149PRKCI0.28830435
150GSK3A0.28507184
151PRKCB0.28025775
152PLK20.26965586
153ACVR1B0.24723123
154PKN10.24197770
155PRKAA10.22728315
156PAK60.20315054
157PTK2B0.19556360
158MAP3K50.19428085
159PDGFRA0.19111288
160STK110.17967822
161MAPK10.17788292
162PRKCA0.17100527

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049646.11471755
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049614.45047641
3Gastric acid secretion_Homo sapiens_hsa049714.24916563
4Inositol phosphate metabolism_Homo sapiens_hsa005623.21723601
5Fatty acid biosynthesis_Homo sapiens_hsa000613.15262166
6Protein digestion and absorption_Homo sapiens_hsa049742.47702763
7Basal cell carcinoma_Homo sapiens_hsa052172.35945977
8Mineral absorption_Homo sapiens_hsa049782.29673247
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.28067412
10Antigen processing and presentation_Homo sapiens_hsa046122.26258265
11Phosphatidylinositol signaling system_Homo sapiens_hsa040702.17059636
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.09327206
13Notch signaling pathway_Homo sapiens_hsa043302.06795483
14Thyroid hormone synthesis_Homo sapiens_hsa049182.04462282
15ECM-receptor interaction_Homo sapiens_hsa045121.97018808
16Axon guidance_Homo sapiens_hsa043601.95757121
17Nicotine addiction_Homo sapiens_hsa050331.95411569
18Bile secretion_Homo sapiens_hsa049761.93171443
19Hippo signaling pathway_Homo sapiens_hsa043901.93059102
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.86940927
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80883928
22Hedgehog signaling pathway_Homo sapiens_hsa043401.74367568
23Dorso-ventral axis formation_Homo sapiens_hsa043201.67029299
24Toxoplasmosis_Homo sapiens_hsa051451.65353978
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45177986
26Rheumatoid arthritis_Homo sapiens_hsa053231.44239554
27TNF signaling pathway_Homo sapiens_hsa046681.43748782
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42296666
29Pancreatic secretion_Homo sapiens_hsa049721.41432115
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35036495
31Arginine biosynthesis_Homo sapiens_hsa002201.34491422
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33847390
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31778107
34Small cell lung cancer_Homo sapiens_hsa052221.31651629
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30808887
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.29374399
37Melanoma_Homo sapiens_hsa052181.28611915
38Insulin secretion_Homo sapiens_hsa049111.27665772
39Taste transduction_Homo sapiens_hsa047421.26514905
40Cocaine addiction_Homo sapiens_hsa050301.26178468
41Wnt signaling pathway_Homo sapiens_hsa043101.25915671
42Influenza A_Homo sapiens_hsa051641.25499657
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23509518
44Nitrogen metabolism_Homo sapiens_hsa009101.22489269
45Amoebiasis_Homo sapiens_hsa051461.21971415
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20545904
47Osteoclast differentiation_Homo sapiens_hsa043801.18732148
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17574214
49Leishmaniasis_Homo sapiens_hsa051401.17097448
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16704715
51Melanogenesis_Homo sapiens_hsa049161.16397956
52Focal adhesion_Homo sapiens_hsa045101.16217231
53Cardiac muscle contraction_Homo sapiens_hsa042601.14753555
54Tight junction_Homo sapiens_hsa045301.13979888
55Adherens junction_Homo sapiens_hsa045201.13908954
56Pathways in cancer_Homo sapiens_hsa052001.13614489
57Measles_Homo sapiens_hsa051621.11275708
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.09801889
59Phototransduction_Homo sapiens_hsa047441.09447620
60Complement and coagulation cascades_Homo sapiens_hsa046101.09419165
61Estrogen signaling pathway_Homo sapiens_hsa049151.09152578
62Morphine addiction_Homo sapiens_hsa050321.08245982
63Colorectal cancer_Homo sapiens_hsa052101.04974547
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04186802
65Herpes simplex infection_Homo sapiens_hsa051681.02489805
66Proteoglycans in cancer_Homo sapiens_hsa052051.00360859
67African trypanosomiasis_Homo sapiens_hsa051430.99928376
68Primary immunodeficiency_Homo sapiens_hsa053400.99232550
69Chemokine signaling pathway_Homo sapiens_hsa040620.94764368
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93921852
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93060520
72Endometrial cancer_Homo sapiens_hsa052130.92754845
73ErbB signaling pathway_Homo sapiens_hsa040120.91098113
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89379614
75Asthma_Homo sapiens_hsa053100.87269392
76Rap1 signaling pathway_Homo sapiens_hsa040150.86940253
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86123719
78Circadian rhythm_Homo sapiens_hsa047100.83954647
79Type II diabetes mellitus_Homo sapiens_hsa049300.83610463
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83180398
81Serotonergic synapse_Homo sapiens_hsa047260.82860595
82TGF-beta signaling pathway_Homo sapiens_hsa043500.82275261
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81809707
84Platelet activation_Homo sapiens_hsa046110.80902317
85Fatty acid metabolism_Homo sapiens_hsa012120.79277386
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79113725
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78512356
88Pancreatic cancer_Homo sapiens_hsa052120.78140695
89MAPK signaling pathway_Homo sapiens_hsa040100.77928402
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77768210
91Renin secretion_Homo sapiens_hsa049240.77586569
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77456573
93Hepatitis C_Homo sapiens_hsa051600.77345657
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.77306900
95Prolactin signaling pathway_Homo sapiens_hsa049170.76593703
96Hepatitis B_Homo sapiens_hsa051610.76434611
97Salivary secretion_Homo sapiens_hsa049700.76431269
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76038737
99Renal cell carcinoma_Homo sapiens_hsa052110.74973768
100Legionellosis_Homo sapiens_hsa051340.74738507
101Dilated cardiomyopathy_Homo sapiens_hsa054140.73851438
102Calcium signaling pathway_Homo sapiens_hsa040200.73069723
103Renin-angiotensin system_Homo sapiens_hsa046140.72726489
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72278937
105Amphetamine addiction_Homo sapiens_hsa050310.72264884
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72109487
107Malaria_Homo sapiens_hsa051440.71480541
108cAMP signaling pathway_Homo sapiens_hsa040240.71289097
109PPAR signaling pathway_Homo sapiens_hsa033200.71015140
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.70879555
111Prostate cancer_Homo sapiens_hsa052150.70755265
112Circadian entrainment_Homo sapiens_hsa047130.70630986
113GABAergic synapse_Homo sapiens_hsa047270.70483230
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68450682
115Long-term depression_Homo sapiens_hsa047300.67960995
116Cholinergic synapse_Homo sapiens_hsa047250.67492673
117Tuberculosis_Homo sapiens_hsa051520.66710586
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66585865
119HTLV-I infection_Homo sapiens_hsa051660.66229118
120Oxytocin signaling pathway_Homo sapiens_hsa049210.65909304
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65686378
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65469288
123Salmonella infection_Homo sapiens_hsa051320.63817401
124Glutamatergic synapse_Homo sapiens_hsa047240.63613181
125Ras signaling pathway_Homo sapiens_hsa040140.63481811
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.62005130
127MicroRNAs in cancer_Homo sapiens_hsa052060.61989434
128Starch and sucrose metabolism_Homo sapiens_hsa005000.61856332
129mTOR signaling pathway_Homo sapiens_hsa041500.60003583
130Fatty acid degradation_Homo sapiens_hsa000710.59233045
131ABC transporters_Homo sapiens_hsa020100.59217685
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58558000
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58429551
134Lysosome_Homo sapiens_hsa041420.58130600
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57272040
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55552944
137Hematopoietic cell lineage_Homo sapiens_hsa046400.55209653
138Chronic myeloid leukemia_Homo sapiens_hsa052200.55057619
139Prion diseases_Homo sapiens_hsa050200.55045504
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54992568
141FoxO signaling pathway_Homo sapiens_hsa040680.54872289
142Autoimmune thyroid disease_Homo sapiens_hsa053200.54512068
143Choline metabolism in cancer_Homo sapiens_hsa052310.53928008
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52767659
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.51985414
1462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49941487
147Regulation of autophagy_Homo sapiens_hsa041400.47880752
148Dopaminergic synapse_Homo sapiens_hsa047280.42811160
149Peroxisome_Homo sapiens_hsa041460.40074515
150p53 signaling pathway_Homo sapiens_hsa041150.35717977
151Ether lipid metabolism_Homo sapiens_hsa005650.35500813
152Linoleic acid metabolism_Homo sapiens_hsa005910.34738801
153Insulin resistance_Homo sapiens_hsa049310.33120045
154Tryptophan metabolism_Homo sapiens_hsa003800.32788980
155Steroid biosynthesis_Homo sapiens_hsa001000.31517458
156Staphylococcus aureus infection_Homo sapiens_hsa051500.30127892
157AMPK signaling pathway_Homo sapiens_hsa041520.29808801
158Glucagon signaling pathway_Homo sapiens_hsa049220.29671451
159Olfactory transduction_Homo sapiens_hsa047400.28993872
160Propanoate metabolism_Homo sapiens_hsa006400.28817183
161Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28339588
162Endocytosis_Homo sapiens_hsa041440.25981274
163Sphingolipid metabolism_Homo sapiens_hsa006000.23970791
164Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23191871
165Insulin signaling pathway_Homo sapiens_hsa049100.21806728
166GnRH signaling pathway_Homo sapiens_hsa049120.16461458
167Apoptosis_Homo sapiens_hsa042100.16054207

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