PAX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)7.88175646
2* metanephric epithelium development (GO:0072207)6.45632452
3gamma-aminobutyric acid transport (GO:0015812)5.83542854
4* metanephric nephron epithelium development (GO:0072243)5.67085064
5* mesenchymal to epithelial transition (GO:0060231)5.61356794
6proximal/distal pattern formation (GO:0009954)5.44617825
7regulation of hippo signaling (GO:0035330)5.32305925
8* metanephric nephron tubule development (GO:0072234)5.30511546
9* metanephric tubule development (GO:0072170)5.30511546
10tachykinin receptor signaling pathway (GO:0007217)5.20340149
11* nephron tubule development (GO:0072080)4.89994827
12positive regulation of digestive system process (GO:0060456)4.78640444
13nephron epithelium morphogenesis (GO:0072088)4.72974743
14nephron tubule morphogenesis (GO:0072078)4.72974743
15* negative regulation of metanephros development (GO:0072217)4.69734464
16organ induction (GO:0001759)4.67538472
17* nephron epithelium development (GO:0072009)4.66944208
18* collecting duct development (GO:0072044)4.43205472
19embryonic skeletal joint morphogenesis (GO:0060272)4.29919377
20sexual reproduction (GO:0019953)4.25766124
21* renal tubule development (GO:0061326)4.22476172
22glomerulus development (GO:0032835)4.17336525
23* metanephros development (GO:0001656)4.12380094
24* regulation of apoptotic process involved in morphogenesis (GO:1902337)4.02596909
25skeletal muscle organ development (GO:0060538)4.01895311
26excretion (GO:0007588)3.99821859
27toxin transport (GO:1901998)3.96607840
28* kidney mesenchyme development (GO:0072074)3.96331036
29renal absorption (GO:0070293)3.93717327
30* regulation of mesonephros development (GO:0061217)3.93199898
31respiratory tube development (GO:0030323)3.93138630
32renal tubule morphogenesis (GO:0061333)3.90744159
33* regulation of metanephros development (GO:0072215)3.90635755
34positive regulation of gastrulation (GO:2000543)3.87866087
35* regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.86856555
36* cranial nerve morphogenesis (GO:0021602)3.81121611
37* branching involved in ureteric bud morphogenesis (GO:0001658)3.79590650
38* positive regulation of metanephros development (GO:0072216)3.77320561
39* regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.76598249
40* negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.76548136
41* mesonephros development (GO:0001823)3.75228843
42coronary vasculature morphogenesis (GO:0060977)3.75088409
43pyrimidine nucleobase catabolic process (GO:0006208)3.73863732
44lymph vessel development (GO:0001945)3.73560661
45* nephron tubule formation (GO:0072079)3.71958082
46cell volume homeostasis (GO:0006884)3.71666983
47diaphragm development (GO:0060539)3.71375562
48* metanephric mesenchyme development (GO:0072075)3.67995990
49sperm motility (GO:0030317)3.64897757
50* regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.61693380
51cardiovascular system development (GO:0072358)3.61438250
52paraxial mesoderm development (GO:0048339)3.61270031
53phosphate ion transport (GO:0006817)3.60757148
54head development (GO:0060322)3.57961498
55acrosome reaction (GO:0007340)3.55542853
56endothelial cell chemotaxis (GO:0035767)3.53699152
57branching involved in salivary gland morphogenesis (GO:0060445)3.49700968
58response to pheromone (GO:0019236)3.49457609
59response to mercury ion (GO:0046689)3.48822948
60embryonic viscerocranium morphogenesis (GO:0048703)3.47013940
61response to parathyroid hormone (GO:0071107)3.46784755
62hippo signaling (GO:0035329)3.45264369
63microtubule severing (GO:0051013)3.41401236
64lung-associated mesenchyme development (GO:0060484)3.40654056
65regulation of organ formation (GO:0003156)3.31891636
66developmental induction (GO:0031128)3.31668531
67forelimb morphogenesis (GO:0035136)3.31661840
68embryonic skeletal system morphogenesis (GO:0048704)3.31054525
69cell proliferation involved in metanephros development (GO:0072203)3.30652928
70neuronal ion channel clustering (GO:0045161)3.29814994
71urate metabolic process (GO:0046415)3.28885742
72behavioral response to nicotine (GO:0035095)3.25440495
73organic cation transport (GO:0015695)3.25352982
74actin filament depolymerization (GO:0030042)3.25022014
75drug transmembrane transport (GO:0006855)3.24911470
76fusion of sperm to egg plasma membrane (GO:0007342)3.21826873
77embryonic forelimb morphogenesis (GO:0035115)3.19147912
78diterpenoid biosynthetic process (GO:0016102)3.16629274
79regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.16487445
80* kidney epithelium development (GO:0072073)3.15905532
81* positive regulation of mesonephros development (GO:0061213)3.15653946
82positive regulation of catenin import into nucleus (GO:0035413)3.15533503
83cell-cell signaling involved in cell fate commitment (GO:0045168)3.14662015
84response to water (GO:0009415)3.12282304
85glomerular basement membrane development (GO:0032836)3.12167849
86cellular response to ammonium ion (GO:0071242)3.11784005
87outer ear morphogenesis (GO:0042473)3.10299455
88transmission of nerve impulse (GO:0019226)3.09977255
89nucleobase catabolic process (GO:0046113)3.06613795
90cerebral cortex neuron differentiation (GO:0021895)3.06575101
91histone H3-K9 demethylation (GO:0033169)3.06338106
92neuron recognition (GO:0008038)3.06204026
93* negative regulation of kidney development (GO:0090185)3.05631383
94response to histamine (GO:0034776)3.04444819
95sperm capacitation (GO:0048240)3.03459178
96* regulation of stem cell maintenance (GO:2000036)3.02941337
97embryonic retina morphogenesis in camera-type eye (GO:0060059)3.01401256
98renal filtration (GO:0097205)3.00301152
99forebrain neuron differentiation (GO:0021879)2.99717900
100regulation of axon extension involved in axon guidance (GO:0048841)2.99462522
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.96802037
102* regulation of kidney development (GO:0090183)2.95957799
103* regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.94829822
104* pattern specification involved in kidney development (GO:0061004)2.93405673
105thyroid gland development (GO:0030878)2.92677927
106embryonic camera-type eye development (GO:0031076)2.92520231
107lysine metabolic process (GO:0006553)2.92443094
108lysine catabolic process (GO:0006554)2.92443094
109* regulation of mesenchymal cell apoptotic process (GO:2001053)2.91364841
110mammary gland alveolus development (GO:0060749)2.91074534
111uterus development (GO:0060065)2.88858282
112cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.88787935
113* mesenchymal cell differentiation involved in kidney development (GO:0072161)2.85425523
114* mesenchymal cell differentiation involved in renal system development (GO:2001012)2.85425523
115activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.84566457
116single strand break repair (GO:0000012)2.83581915
117* kidney development (GO:0001822)2.83208701
118embryonic digestive tract development (GO:0048566)2.83149497
119neuron projection extension involved in neuron projection guidance (GO:1902284)2.82781875
120axon extension involved in axon guidance (GO:0048846)2.82781875
121mesodermal cell differentiation (GO:0048333)2.81582243
122* positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.81461446
123response to acidic pH (GO:0010447)2.81207435
124skeletal system morphogenesis (GO:0048705)2.81166610
125cell-cell junction maintenance (GO:0045217)2.80031139
126neurofilament cytoskeleton organization (GO:0060052)2.79462031
127camera-type eye morphogenesis (GO:0048593)2.79124497
128phosphate ion transmembrane transport (GO:0035435)2.78979794
129regulation of transcription involved in cell fate commitment (GO:0060850)2.78537359
130dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.78245509
131hyperosmotic response (GO:0006972)2.77399111
132* regulation of glomerulus development (GO:0090192)2.76696033
133regulation of neuron migration (GO:2001222)2.76656907
134neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.75136723
135neuron maturation (GO:0042551)2.74217693
136positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.73107542
137apical protein localization (GO:0045176)2.73049553
138planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71042598
139sodium-independent organic anion transport (GO:0043252)2.70761383
140negative regulation of neurotransmitter secretion (GO:0046929)2.70554240
141morphogenesis of an epithelial sheet (GO:0002011)2.70168824
142cellular response to vitamin D (GO:0071305)2.69994337
143kidney morphogenesis (GO:0060993)2.67590947
144beta-amyloid metabolic process (GO:0050435)2.66220567
145peptidyl-proline hydroxylation (GO:0019511)2.66089293
146* urogenital system development (GO:0001655)2.65822912
147positive regulation of p38MAPK cascade (GO:1900745)2.65821297
148regulation of axon guidance (GO:1902667)2.65521333
149central nervous system myelination (GO:0022010)2.65470711
150axon ensheathment in central nervous system (GO:0032291)2.65470711
151ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.64891771
152calcium ion-dependent exocytosis (GO:0017156)2.64820490
153auditory receptor cell differentiation (GO:0042491)2.63878540
154polyol transport (GO:0015791)2.63327922
155* mesonephric epithelium development (GO:0072163)2.62871119
156positive regulation of vesicle fusion (GO:0031340)2.62541142
157quaternary ammonium group transport (GO:0015697)2.62370410
158protein polyglutamylation (GO:0018095)2.62335968
159semaphorin-plexin signaling pathway (GO:0071526)2.62061112
160* mesonephric tubule development (GO:0072164)2.61790139
161regulation of cilium movement (GO:0003352)2.61208150
162drug transport (GO:0015893)2.61068664
163ureteric bud development (GO:0001657)2.60421173
164embryonic organ morphogenesis (GO:0048562)2.59413334
165* regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.58785080
166positive regulation of action potential (GO:0045760)2.57517154
167positive regulation of protein kinase C signaling (GO:0090037)2.56703305
168regulation of glutamate receptor signaling pathway (GO:1900449)2.55546824
169cellular response to pH (GO:0071467)2.54517431
170amino-acid betaine metabolic process (GO:0006577)2.54156134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.43807966
2* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.91943403
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.62092114
4ESR1_20079471_ChIP-ChIP_T-47D_Human2.61743309
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56821491
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54734279
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54734279
8DROSHA_22980978_ChIP-Seq_HELA_Human2.40454869
9EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.39311048
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.36021867
11CLOCK_20551151_ChIP-Seq_293T_Human2.23903137
12* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22857370
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.20784269
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.15623910
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.11283994
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.07406557
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05895076
18* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01139636
19* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00480144
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96731921
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.96346951
22* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95368191
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.94858832
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.94557659
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92440452
26AR_21909140_ChIP-Seq_LNCAP_Human1.89740367
27* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88008293
28* RING1B_27294783_Chip-Seq_NPCs_Mouse1.86236075
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84847369
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79903400
31* REST_21632747_ChIP-Seq_MESCs_Mouse1.79220763
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78428761
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76632301
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75360951
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72929006
36* CTCF_27219007_Chip-Seq_Bcells_Human1.71714569
37* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.68424616
38* TP53_20018659_ChIP-ChIP_R1E_Mouse1.68411289
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68297520
40* EZH2_27294783_Chip-Seq_ESCs_Mouse1.66431739
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.66117879
42* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65952760
43* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65862181
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63461168
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62216706
46* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61507406
47* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61195395
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59674475
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58222516
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57159758
51* ISL1_27105846_Chip-Seq_CPCs_Mouse1.56725426
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54377089
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52268822
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.51766828
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.51740152
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51132283
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49553665
58LXR_22292898_ChIP-Seq_THP-1_Human1.48181460
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.47968655
60* CBX2_27304074_Chip-Seq_ESCs_Mouse1.47259601
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46919839
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45807646
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45161719
64* KDM2B_26808549_Chip-Seq_K562_Human1.42654120
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.41487842
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.41364340
67* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40307447
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40024663
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39370345
70EZH2_22144423_ChIP-Seq_EOC_Human1.38378001
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33788679
72RACK7_27058665_Chip-Seq_MCF-7_Human1.33327177
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.32649696
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31132393
75* RNF2_27304074_Chip-Seq_ESCs_Mouse1.30119654
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28935847
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28935847
78* REST_18959480_ChIP-ChIP_MESCs_Mouse1.28812658
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.28370031
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25397485
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24595492
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.23922037
83STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.23333489
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19096186
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18180645
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17090012
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.15764885
88* RNF2_27304074_Chip-Seq_NSC_Mouse1.15705870
89* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15657136
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15549087
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15208882
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15200442
93AHR_22903824_ChIP-Seq_MCF-7_Human1.15169442
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14715564
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13703370
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09962794
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09891503
98P68_20966046_ChIP-Seq_HELA_Human1.08301117
99SMC4_20622854_ChIP-Seq_HELA_Human1.08283881
100* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07415707
101* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05565364
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.04267255
103* ARNT_22903824_ChIP-Seq_MCF-7_Human1.03117777
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03031701
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.01626128
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00915449
107CREB1_26743006_Chip-Seq_LNCaP_Human1.00794644
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00042013
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99843238
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99795321
111WDR5_24793694_ChIP-Seq_LNCAP_Human0.99180010
112MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97641104
113TP53_22127205_ChIP-Seq_IMR90_Human0.96821174
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96671003
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.96455820
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96383303
117ATF3_27146783_Chip-Seq_COLON_Human0.96063612
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94660260
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94554905
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93631765
121HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93196588
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91776185
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91189769
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.91074944
125ZNF274_21170338_ChIP-Seq_K562_Hela0.90949820
126* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.90863334
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90137052
128* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85560758
129* SMAD4_21741376_ChIP-Seq_HESCs_Human0.83452921
130E2F1_20622854_ChIP-Seq_HELA_Human0.83376603
131PHF8_20622854_ChIP-Seq_HELA_Human0.82153622
132TP63_22573176_ChIP-Seq_HFKS_Human0.80920401
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80782734
134TP53_23651856_ChIP-Seq_MEFs_Mouse0.80709390
135SOX11_22085726_ChIP-Seq_ESNs_Mouse0.80283429
136ELF1_20517297_ChIP-Seq_JURKAT_Human0.79853181
137* SA1_27219007_Chip-Seq_ERYTHROID_Human0.79719762
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79574995
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79538898
140* SA1_27219007_Chip-Seq_Bcells_Human0.77441427
141* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75554682
142CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74096005
143CTCF_20526341_ChIP-Seq_ESCs_Human0.71824539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003942_abnormal_urinary_system3.97075452
2* MP0000534_abnormal_ureter_morphology3.92281189
3MP0003880_abnormal_central_pattern3.86984216
4MP0005623_abnormal_meninges_morphology3.66506584
5MP0004043_abnormal_pH_regulation3.32102651
6MP0006276_abnormal_autonomic_nervous3.02667855
7MP0002138_abnormal_hepatobiliary_system2.80418137
8MP0000537_abnormal_urethra_morphology2.78589177
9MP0009053_abnormal_anal_canal2.77288802
10MP0002928_abnormal_bile_duct2.55923082
11MP0003123_paternal_imprinting2.52591534
12MP0002822_catalepsy2.51495368
13MP0003385_abnormal_body_wall2.39763135
14MP0010386_abnormal_urinary_bladder2.36368987
15MP0005423_abnormal_somatic_nervous2.35009369
16MP0005410_abnormal_fertilization2.30184262
17MP0005670_abnormal_white_adipose2.30006525
18MP0010030_abnormal_orbit_morphology2.28570858
19MP0003879_abnormal_hair_cell2.22356271
20MP0001348_abnormal_lacrimal_gland2.22352744
21MP0002249_abnormal_larynx_morphology2.19797605
22MP0001756_abnormal_urination2.13767358
23MP0005377_hearing/vestibular/ear_phenot2.05035790
24MP0003878_abnormal_ear_physiology2.05035790
25MP0003252_abnormal_bile_duct2.04021709
26MP0002139_abnormal_hepatobiliary_system1.99381125
27MP0004272_abnormal_basement_membrane1.97169725
28MP0003941_abnormal_skin_development1.92666689
29MP0009250_abnormal_appendicular_skeleto1.92279460
30MP0003115_abnormal_respiratory_system1.89564530
31MP0002638_abnormal_pupillary_reflex1.82898593
32MP0001765_abnormal_ion_homeostasis1.82866907
33MP0004233_abnormal_muscle_weight1.82680008
34MP0003122_maternal_imprinting1.75754151
35MP0000678_abnormal_parathyroid_gland1.75177743
36MP0000538_abnormal_urinary_bladder1.73665831
37MP0009643_abnormal_urine_homeostasis1.67832995
38MP0004019_abnormal_vitamin_homeostasis1.65917849
39MP0001879_abnormal_lymphatic_vessel1.63798671
40MP0001501_abnormal_sleep_pattern1.62877863
41MP0002932_abnormal_joint_morphology1.61637237
42MP0003937_abnormal_limbs/digits/tail_de1.60958632
43MP0001849_ear_inflammation1.59605141
44MP0004885_abnormal_endolymph1.58763874
45MP0003121_genomic_imprinting1.56188296
46MP0005360_urolithiasis1.54343561
47MP0005084_abnormal_gallbladder_morpholo1.52209813
48MP0003315_abnormal_perineum_morphology1.51005022
49* MP0003938_abnormal_ear_development1.50240488
50MP0002735_abnormal_chemical_nociception1.50227147
51* MP0002135_abnormal_kidney_morphology1.43565490
52MP0002282_abnormal_trachea_morphology1.42208310
53MP0005332_abnormal_amino_acid1.42117583
54* MP0002136_abnormal_kidney_physiology1.42094380
55MP0002697_abnormal_eye_size1.35950329
56MP0003705_abnormal_hypodermis_morpholog1.33934588
57MP0003195_calcinosis1.31182279
58MP0002653_abnormal_ependyma_morphology1.30928871
59MP0001486_abnormal_startle_reflex1.29987065
60MP0010234_abnormal_vibrissa_follicle1.28828460
61MP0002733_abnormal_thermal_nociception1.23831229
62MP0002272_abnormal_nervous_system1.21149614
63* MP0000026_abnormal_inner_ear1.20929165
64MP0001963_abnormal_hearing_physiology1.17411236
65MP0004858_abnormal_nervous_system1.17239479
66MP0002114_abnormal_axial_skeleton1.16626413
67MP0005408_hypopigmentation1.16187901
68MP0003635_abnormal_synaptic_transmissio1.14427600
69MP0000566_synostosis1.13636042
70MP0001970_abnormal_pain_threshold1.12887089
71MP0003755_abnormal_palate_morphology1.12549730
72* MP0002085_abnormal_embryonic_tissue1.10968248
73MP0003935_abnormal_craniofacial_develop1.08847087
74MP0010368_abnormal_lymphatic_system1.08576299
75MP0005248_abnormal_Harderian_gland1.07909283
76MP0005636_abnormal_mineral_homeostasis1.07144257
77MP0001293_anophthalmia1.07042152
78MP0002109_abnormal_limb_morphology1.06762965
79* MP0002092_abnormal_eye_morphology1.06302185
80MP0000049_abnormal_middle_ear1.04604587
81MP0002111_abnormal_tail_morphology1.03727804
82MP0003119_abnormal_digestive_system1.02610237
83MP0004859_abnormal_synaptic_plasticity1.02597437
84MP0002557_abnormal_social/conspecific_i1.02515875
85MP0001958_emphysema1.02318401
86MP0000428_abnormal_craniofacial_morphol1.02236706
87MP0005167_abnormal_blood-brain_barrier1.01831708
88* MP0003698_abnormal_male_reproductive1.01589029
89MP0000230_abnormal_systemic_arterial1.01360797
90* MP0003861_abnormal_nervous_system1.00959010
91* MP0003936_abnormal_reproductive_system1.00797462
92* MP0002752_abnormal_somatic_nervous1.00228926
93MP0002116_abnormal_craniofacial_bone0.99728624
94MP0002233_abnormal_nose_morphology0.99559377
95MP0000432_abnormal_head_morphology0.97755058
96MP0002115_abnormal_skeleton_extremities0.97111446
97MP0001440_abnormal_grooming_behavior0.95943170
98MP0008872_abnormal_physiological_respon0.95428318
99* MP0002084_abnormal_developmental_patter0.93975367
100MP0009672_abnormal_birth_weight0.93962083
101* MP0001286_abnormal_eye_development0.93702445
102MP0002896_abnormal_bone_mineralization0.92162877
103* MP0002882_abnormal_neuron_morphology0.92001127
104MP0003283_abnormal_digestive_organ0.91743112
105MP0002909_abnormal_adrenal_gland0.90905497
106MP0008961_abnormal_basal_metabolism0.90765327
107MP0001270_distended_abdomen0.89929949
108MP0002067_abnormal_sensory_capabilities0.88957300
109MP0000733_abnormal_muscle_development0.88948924
110* MP0000778_abnormal_nervous_system0.87668801
111MP0000163_abnormal_cartilage_morphology0.85663730
112MP0003890_abnormal_embryonic-extraembry0.85308739
113MP0000681_abnormal_thyroid_gland0.85165759
114MP0000955_abnormal_spinal_cord0.84696028
115MP0004133_heterotaxia0.83449369
116MP0005375_adipose_tissue_phenotype0.82696978
117MP0005666_abnormal_adipose_tissue0.81667245
118MP0000003_abnormal_adipose_tissue0.81541119
119MP0002063_abnormal_learning/memory/cond0.79172775
120MP0001915_intracranial_hemorrhage0.78890194
121MP0004742_abnormal_vestibular_system0.78772169
122MP0002938_white_spotting0.78572993
123MP0009745_abnormal_behavioral_response0.78349108
124MP0003011_delayed_dark_adaptation0.78085037
125MP0002572_abnormal_emotion/affect_behav0.77620514
126MP0005220_abnormal_exocrine_pancreas0.76252303
127MP0002089_abnormal_postnatal_growth/wei0.76121681
128MP0000631_abnormal_neuroendocrine_gland0.75727035
129MP0000462_abnormal_digestive_system0.75224700
130MP0004134_abnormal_chest_morphology0.75014037
131MP0000013_abnormal_adipose_tissue0.74545345
132MP0000762_abnormal_tongue_morphology0.74098002
133MP0001340_abnormal_eyelid_morphology0.73531981
134MP0002184_abnormal_innervation0.72630705
135MP0001697_abnormal_embryo_size0.72604837
136MP0002734_abnormal_mechanical_nocicepti0.72535003
137MP0004197_abnormal_fetal_growth/weight/0.71914877
138MP0002177_abnormal_outer_ear0.71726439
139MP0002796_impaired_skin_barrier0.70585320
140MP0004085_abnormal_heartbeat0.70575857
141MP0002168_other_aberrant_phenotype0.70070609
142* MP0002152_abnormal_brain_morphology0.69327987
143* MP0002081_perinatal_lethality0.68955078
144MP0001968_abnormal_touch/_nociception0.68331539
145MP0001485_abnormal_pinna_reflex0.68297123
146MP0009703_decreased_birth_body0.68282477
147MP0005503_abnormal_tendon_morphology0.67882021
148MP0001502_abnormal_circadian_rhythm0.67262937
149MP0002069_abnormal_eating/drinking_beha0.66952668
150* MP0002161_abnormal_fertility/fecundity0.66778960
151MP0001188_hyperpigmentation0.65525604
152MP0004510_myositis0.62755051
153MP0003943_abnormal_hepatobiliary_system0.62302846
154MP0005409_darkened_coat_color0.60439083
155MP0003959_abnormal_lean_body0.60423665
156MP0001929_abnormal_gametogenesis0.60106973
157MP0008569_lethality_at_weaning0.59305026

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.81771423
2Hypokalemic alkalosis (HP:0001949)6.20038637
3Increased circulating renin level (HP:0000848)5.61437645
4Abnormality of chloride homeostasis (HP:0011422)5.53679368
5Hypomagnesemia (HP:0002917)5.13368728
6Polyuria (HP:0000103)5.04039913
7Gout (HP:0001997)4.99859174
8Hyperactive renin-angiotensin system (HP:0000841)4.92346216
9Abnormal urine output (HP:0012590)4.65514439
10Shawl scrotum (HP:0000049)4.58448565
11Abnormality of renal excretion (HP:0011036)4.28430852
12Abnormality of magnesium homeostasis (HP:0004921)4.25886443
13Abnormal pancreas size (HP:0012094)4.25545935
14Renal salt wasting (HP:0000127)4.18698835
15Abnormal drinking behavior (HP:0030082)3.90907590
16Polydipsia (HP:0001959)3.90907590
17Hyperaldosteronism (HP:0000859)3.90288684
18* Bicornuate uterus (HP:0000813)3.83789295
19Tetany (HP:0001281)3.53134557
20Abnormality of renin-angiotensin system (HP:0000847)3.33523969
21Alkalosis (HP:0001948)3.29874679
22Increased purine levels (HP:0004368)3.29259128
23Hyperuricemia (HP:0002149)3.29259128
24Hypercalciuria (HP:0002150)3.23504639
25Supranuclear gaze palsy (HP:0000605)3.03959674
26* Focal segmental glomerulosclerosis (HP:0000097)2.96036668
27Hepatoblastoma (HP:0002884)2.91789521
28Hypokalemia (HP:0002900)2.89073161
29* Glomerulosclerosis (HP:0000096)2.85040950
30Thoracolumbar scoliosis (HP:0002944)2.72243583
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71105701
32Short 4th metacarpal (HP:0010044)2.71105701
33Hyponatremia (HP:0002902)2.51689884
34Midline defect of the nose (HP:0004122)2.45561692
35Unilateral renal agenesis (HP:0000122)2.42630664
36Myokymia (HP:0002411)2.41623815
37Neonatal hypoglycemia (HP:0001998)2.40279232
38* Facial shape deformation (HP:0011334)2.39567232
39* Potter facies (HP:0002009)2.39567232
40Proximal tubulopathy (HP:0000114)2.33488420
41Abnormality of potassium homeostasis (HP:0011042)2.30208976
42Abnormal number of incisors (HP:0011064)2.28509956
43Mesangial abnormality (HP:0001966)2.28307738
44Abnormality of purine metabolism (HP:0004352)2.26743265
45Enlarged kidneys (HP:0000105)2.26462396
46Generalized aminoaciduria (HP:0002909)2.25812691
47Renal duplication (HP:0000075)2.23733228
48Lymphangioma (HP:0100764)2.23092799
49Abnormality of urine glucose concentration (HP:0011016)2.22447259
50Glycosuria (HP:0003076)2.22447259
51Abnormality of the nasal septum (HP:0000419)2.21754619
52Tubular atrophy (HP:0000092)2.21707946
53Progressive cerebellar ataxia (HP:0002073)2.19326050
54Osteomalacia (HP:0002749)2.18817299
55* Renal hypoplasia (HP:0000089)2.17206715
56Tubulointerstitial abnormality (HP:0001969)2.16946266
57Tubulointerstitial nephritis (HP:0001970)2.16711140
58Abnormality of the calcaneus (HP:0008364)2.16292180
59Abnormality of sodium homeostasis (HP:0010931)2.16079040
60Shallow orbits (HP:0000586)2.15194068
61Ulnar bowing (HP:0003031)2.14714873
62Hyperphosphaturia (HP:0003109)2.07994617
63Hypophosphatemic rickets (HP:0004912)2.07727544
64Nephrocalcinosis (HP:0000121)2.06178454
65Nuclear cataract (HP:0100018)2.05468400
66Thyroid-stimulating hormone excess (HP:0002925)2.04663438
67High anterior hairline (HP:0009890)2.03401649
68Renal tubular acidosis (HP:0001947)2.00423379
69Metaphyseal cupping (HP:0003021)2.00020927
70Choanal stenosis (HP:0000452)1.98115047
71Generalized muscle weakness (HP:0003324)1.96390869
72Adrenal overactivity (HP:0002717)1.96204774
73Large eyes (HP:0001090)1.95219928
74Sensorimotor neuropathy (HP:0007141)1.95106935
75* Stage 5 chronic kidney disease (HP:0003774)1.94655152
76Thin bony cortex (HP:0002753)1.91033767
77Intellectual disability, moderate (HP:0002342)1.90580433
78Hypotension (HP:0002615)1.90098529
79Hyperkalemia (HP:0002153)1.89580621
80Abnormal urine phosphate concentration (HP:0012599)1.87349971
81Rickets (HP:0002748)1.86880947
82Down-sloping shoulders (HP:0200021)1.86181863
83Tubulointerstitial fibrosis (HP:0005576)1.86059445
84Abnormality of fatty-acid metabolism (HP:0004359)1.85035999
85Abnormality of the lacrimal duct (HP:0011481)1.81898759
86Chondrocalcinosis (HP:0000934)1.79712553
87Broad thumb (HP:0011304)1.77370488
88Calcaneovalgus deformity (HP:0001848)1.76632802
89Abnormality of the 4th metacarpal (HP:0010012)1.75868431
90Delayed epiphyseal ossification (HP:0002663)1.75759809
91Morphological abnormality of the middle ear (HP:0008609)1.75339318
92Omphalocele (HP:0001539)1.74563644
93Camptodactyly of toe (HP:0001836)1.73876184
94Abnormality of the middle phalanges of the toes (HP:0010183)1.71265696
95Abnormality of Sharpey fibers (HP:0100685)1.70778744
96Papillary thyroid carcinoma (HP:0002895)1.69553345
97Abnormal lung lobation (HP:0002101)1.69445206
98Nephroblastoma (Wilms tumor) (HP:0002667)1.69332778
99Abnormality of the renal medulla (HP:0100957)1.68594249
100Embryonal renal neoplasm (HP:0011794)1.67991114
101Renovascular hypertension (HP:0100817)1.67868139
102Absent eyelashes (HP:0000561)1.67798094
103Scapular winging (HP:0003691)1.66707291
104Hip contracture (HP:0003273)1.66665111
105Dehydration (HP:0001944)1.66565668
106Stridor (HP:0010307)1.65158621
107Arterial tortuosity (HP:0005116)1.64392519
108Broad distal phalanx of finger (HP:0009836)1.64066949
109Abnormality of nucleobase metabolism (HP:0010932)1.60963478
110Diastasis recti (HP:0001540)1.60177032
111Turricephaly (HP:0000262)1.59639629
112Muscle fiber splitting (HP:0003555)1.58302718
113Bilateral sensorineural hearing impairment (HP:0008619)1.56566047
114Hypophosphatemia (HP:0002148)1.56500502
115Deformed tarsal bones (HP:0008119)1.55860731
116Abnormality of glutamine family amino acid metabolism (HP:0010902)1.55736886
117Abnormality of the antihelix (HP:0009738)1.55672220
118Myelomeningocele (HP:0002475)1.55340257
119Abnormality of the nasolacrimal system (HP:0000614)1.52237901
120Broad finger (HP:0001500)1.52100003
121Severe visual impairment (HP:0001141)1.51340930
122Coronal craniosynostosis (HP:0004440)1.50766436
123Hypoplasia of the uterus (HP:0000013)1.50604572
124Hyperglycinuria (HP:0003108)1.49447228
125Skull defect (HP:0001362)1.49142677
126Double outlet right ventricle (HP:0001719)1.47943237
127Congenital malformation of the right heart (HP:0011723)1.47943237
128Bilateral microphthalmos (HP:0007633)1.47856872
129* Nephrolithiasis (HP:0000787)1.47815304
130Broad toe (HP:0001837)1.45788026
131Broad phalanges of the hand (HP:0009768)1.44981184
132Metaphyseal dysplasia (HP:0100255)1.43576106
133Broad metatarsal (HP:0001783)1.43164458
134Abnormal ossification of hand bones (HP:0005921)1.42942947
135Anophthalmia (HP:0000528)1.42679916
136Supernumerary ribs (HP:0005815)1.41262777
137Exotropia (HP:0000577)1.40116208
138Abnormality of the aortic arch (HP:0012303)1.38674845
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.33871865
140Hemorrhage of the eye (HP:0011885)1.31966778
141Enlarged epiphyses (HP:0010580)1.31013935
142Periauricular skin pits (HP:0100277)1.30778618
143Preauricular pit (HP:0004467)1.30778618
144Zonular cataract (HP:0010920)1.30621449
145Late onset (HP:0003584)1.27417199
146Supernumerary bones of the axial skeleton (HP:0009144)1.25513544
147Polar cataract (HP:0010696)1.24922850
148Truncal obesity (HP:0001956)1.24779781
149Bony spicule pigmentary retinopathy (HP:0007737)1.24460159
150Nephrogenic diabetes insipidus (HP:0009806)1.24214702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.60330936
2WNK45.41204595
3OXSR14.44777147
4LATS13.04458171
5MARK12.86051423
6MST42.77236097
7ICK2.64475955
8STK392.32296387
9WNK12.27550885
10STK38L2.27086715
11PTK22.10388020
12TTN2.03791202
13LATS21.86303948
14NTRK31.77967189
15TRIB31.70927485
16PTK61.63747316
17EPHB21.63190001
18PLK41.61599924
19MAPK151.59335003
20LRRK21.53336372
21PAK41.52423234
22SGK4941.47735904
23SGK2231.47735904
24STK101.38947429
25NEK61.36380367
26MET1.36147873
27EPHA21.35015732
28BMX1.34666650
29MINK11.33651110
30PAK31.33304669
31NEK11.31951523
32STK381.28948319
33BCR1.28555515
34PAK21.27941625
35NTRK11.22841682
36PDGFRA1.22597293
37MAP3K91.19442614
38ALK1.18980500
39LIMK11.16248614
40CSNK1A1L1.13198802
41ERBB41.13180737
42MAP2K61.08728356
43SIK21.06431071
44ROCK21.00534701
45TAF10.99561723
46MARK20.99050475
47FGFR10.98858684
48MAP3K20.97612189
49RIPK10.94596943
50PRKCI0.93605548
51TYRO30.91232705
52CSNK1G10.89928031
53RPS6KA20.88139235
54EEF2K0.84935640
55DDR20.84269568
56BRD40.84134706
57NTRK20.83526204
58TTK0.83398801
59AKT30.82872446
60DYRK20.82152453
61MAP3K80.82100262
62CAMK1G0.80597438
63MAP3K70.79992489
64INSRR0.79771389
65MTOR0.79196817
66PAK60.78249739
67CSNK1G30.77967465
68ROCK10.77143104
69LMTK20.77071409
70PRKCH0.76893820
71MAP3K40.75796582
72TESK10.75140193
73MAP3K100.73919097
74NME10.73125223
75PRKCG0.72757745
76STK30.72654840
77UHMK10.70801861
78DYRK1B0.68404087
79CASK0.67427578
80FGFR20.65982760
81PRKD30.65899621
82PRKAA10.65298471
83SGK20.65082659
84RPS6KB20.64750916
85SGK30.64380641
86CAMKK10.64363156
87MAP2K70.61812003
88CSNK1G20.60927848
89CSNK1E0.58123404
90MKNK10.57968979
91PASK0.57471468
92STK110.56734849
93FER0.55848161
94CAMKK20.55700571
95AKT20.52423522
96ADRBK20.51515008
97KSR10.51431552
98ILK0.51297529
99NEK20.51291238
100MAPK130.50448721
101ARAF0.50215099
102EPHB10.50110538
103ERBB30.50001323
104PNCK0.48908577
105TESK20.48719482
106SGK10.48644244
107PTK2B0.48063638
108MYLK0.47574542
109CDK120.47511691
110PDPK10.45886735
111CAMK1D0.44261521
112PKN20.43875389
113PRKAA20.43825698
114GSK3A0.42066953
115CDK80.41921327
116RET0.41874618
117ERBB20.41401435
118TAOK10.41312897
119PAK10.40868258
120ACVR1B0.38677307
121PRKD20.37366109
122PLK30.37327764
123BCKDK0.37318392
124TGFBR10.37138071
125FRK0.36634255
126PRKCE0.36607858
127DYRK1A0.36225070
128CDK90.35833617
129MST1R0.35733878
130BRAF0.35008710
131CAMK2G0.33538522
132CAMK2B0.33338962
133PRKCZ0.32969145
134MAP2K20.32891355
135* MAPK80.32628823
136GSK3B0.32370173
137GRK10.32173987
138SRC0.31876712
139PKN10.31502934
140MAPK90.31194409
141CDK50.31004790
142KSR20.29499049
143CAMK10.28168690
144KDR0.27332646
145CDK30.27171344
146SIK10.27156630
147CSNK1A10.26003279
148PDK10.25984009
149CAMK40.24291289
150RPS6KA60.22757917
151PRKCD0.22350868
152MAPK100.22157576
153HIPK20.22134749
154RPS6KA10.22129945
155SMG10.21778242
156DYRK30.20594145
157RPS6KC10.20481334

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.05204634
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.78330816
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.55454658
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40168180
5Nicotine addiction_Homo sapiens_hsa050332.34956973
6Hedgehog signaling pathway_Homo sapiens_hsa043402.32483685
7Hippo signaling pathway_Homo sapiens_hsa043902.31430229
8Butanoate metabolism_Homo sapiens_hsa006502.25650199
9Basal cell carcinoma_Homo sapiens_hsa052172.22950675
10Mineral absorption_Homo sapiens_hsa049782.21902002
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.01844395
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.94874216
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87839936
14GABAergic synapse_Homo sapiens_hsa047271.83923273
15Axon guidance_Homo sapiens_hsa043601.76512114
16ECM-receptor interaction_Homo sapiens_hsa045121.70336397
17Bladder cancer_Homo sapiens_hsa052191.68732930
18Tight junction_Homo sapiens_hsa045301.64500447
19Morphine addiction_Homo sapiens_hsa050321.60936785
20Small cell lung cancer_Homo sapiens_hsa052221.56966616
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54625449
22Lysine degradation_Homo sapiens_hsa003101.53452941
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51963932
24MicroRNAs in cancer_Homo sapiens_hsa052061.48995318
25Focal adhesion_Homo sapiens_hsa045101.48860841
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48380073
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43574560
28Proteoglycans in cancer_Homo sapiens_hsa052051.42643061
29Bile secretion_Homo sapiens_hsa049761.39824963
30Cardiac muscle contraction_Homo sapiens_hsa042601.39447222
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31251085
32Starch and sucrose metabolism_Homo sapiens_hsa005001.30241757
33Phenylalanine metabolism_Homo sapiens_hsa003601.30012106
34Thyroid hormone synthesis_Homo sapiens_hsa049181.29422297
35Fatty acid biosynthesis_Homo sapiens_hsa000611.28102305
36Gastric acid secretion_Homo sapiens_hsa049711.27467251
37Adherens junction_Homo sapiens_hsa045201.23109914
38Histidine metabolism_Homo sapiens_hsa003401.22048215
39Propanoate metabolism_Homo sapiens_hsa006401.21122068
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20407889
41Collecting duct acid secretion_Homo sapiens_hsa049661.18670678
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17292943
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16086123
44Endometrial cancer_Homo sapiens_hsa052131.11464787
45Non-small cell lung cancer_Homo sapiens_hsa052231.10142057
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09539816
47Circadian rhythm_Homo sapiens_hsa047101.09506890
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08670859
49Protein digestion and absorption_Homo sapiens_hsa049741.07031719
50Fatty acid metabolism_Homo sapiens_hsa012121.04602006
51Glioma_Homo sapiens_hsa052141.04513156
52Melanoma_Homo sapiens_hsa052181.01835397
53Renal cell carcinoma_Homo sapiens_hsa052111.01592454
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00693800
55Glutamatergic synapse_Homo sapiens_hsa047240.99618205
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99185558
57Chronic myeloid leukemia_Homo sapiens_hsa052200.98535899
58Biosynthesis of amino acids_Homo sapiens_hsa012300.98008024
59Circadian entrainment_Homo sapiens_hsa047130.96938134
60Prostate cancer_Homo sapiens_hsa052150.96783391
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95555312
62Glutathione metabolism_Homo sapiens_hsa004800.94943905
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93356195
64Serotonergic synapse_Homo sapiens_hsa047260.93108106
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92817639
66Pyruvate metabolism_Homo sapiens_hsa006200.92282843
67TGF-beta signaling pathway_Homo sapiens_hsa043500.91469529
68Sulfur metabolism_Homo sapiens_hsa009200.91206918
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91009346
70Dopaminergic synapse_Homo sapiens_hsa047280.90676414
71Insulin secretion_Homo sapiens_hsa049110.90174971
72Cholinergic synapse_Homo sapiens_hsa047250.88499785
73Wnt signaling pathway_Homo sapiens_hsa043100.88258888
74Melanogenesis_Homo sapiens_hsa049160.88102493
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87919674
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.87895192
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86834948
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85635789
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84334050
80Carbon metabolism_Homo sapiens_hsa012000.83846623
81Thyroid cancer_Homo sapiens_hsa052160.83266394
82Pathways in cancer_Homo sapiens_hsa052000.82596497
83VEGF signaling pathway_Homo sapiens_hsa043700.80564503
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.80480952
85MAPK signaling pathway_Homo sapiens_hsa040100.78714186
86Pancreatic cancer_Homo sapiens_hsa052120.78480084
87cAMP signaling pathway_Homo sapiens_hsa040240.77655124
88Salivary secretion_Homo sapiens_hsa049700.77460206
89Phototransduction_Homo sapiens_hsa047440.77147209
90Gap junction_Homo sapiens_hsa045400.76000380
91Olfactory transduction_Homo sapiens_hsa047400.75461420
92Rap1 signaling pathway_Homo sapiens_hsa040150.75047209
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74644724
94Oocyte meiosis_Homo sapiens_hsa041140.73961966
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.73914418
96Arginine and proline metabolism_Homo sapiens_hsa003300.73334956
97Estrogen signaling pathway_Homo sapiens_hsa049150.71928867
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71142257
99Fatty acid degradation_Homo sapiens_hsa000710.69292176
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69217309
101HIF-1 signaling pathway_Homo sapiens_hsa040660.68931859
102Choline metabolism in cancer_Homo sapiens_hsa052310.66670640
103Vibrio cholerae infection_Homo sapiens_hsa051100.65115970
104ErbB signaling pathway_Homo sapiens_hsa040120.65036432
105FoxO signaling pathway_Homo sapiens_hsa040680.64793057
106Nitrogen metabolism_Homo sapiens_hsa009100.64056610
107Colorectal cancer_Homo sapiens_hsa052100.63638107
108Amoebiasis_Homo sapiens_hsa051460.63444415
109Cell cycle_Homo sapiens_hsa041100.63161903
110Endocytosis_Homo sapiens_hsa041440.62991600
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.61660200
112Cocaine addiction_Homo sapiens_hsa050300.61156061
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59580517
114Taste transduction_Homo sapiens_hsa047420.59026247
115Retinol metabolism_Homo sapiens_hsa008300.57849166
116Long-term potentiation_Homo sapiens_hsa047200.57201091
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55256925
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55164974
119Notch signaling pathway_Homo sapiens_hsa043300.54914311
120Ovarian steroidogenesis_Homo sapiens_hsa049130.54319931
121Type II diabetes mellitus_Homo sapiens_hsa049300.54142978
122Amphetamine addiction_Homo sapiens_hsa050310.53915702
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.53914200
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53404558
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52831811
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52563599
127Tryptophan metabolism_Homo sapiens_hsa003800.51961502
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51661429
129GnRH signaling pathway_Homo sapiens_hsa049120.51598985
130Glycerolipid metabolism_Homo sapiens_hsa005610.51573206
131Dilated cardiomyopathy_Homo sapiens_hsa054140.51113716
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47593128
133Oxytocin signaling pathway_Homo sapiens_hsa049210.47488039
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.47339686
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45162358
136Synaptic vesicle cycle_Homo sapiens_hsa047210.44766007
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43464898
138beta-Alanine metabolism_Homo sapiens_hsa004100.42181652
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40303525
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39589677
141Ras signaling pathway_Homo sapiens_hsa040140.38947175
142Dorso-ventral axis formation_Homo sapiens_hsa043200.38623626
143Peroxisome_Homo sapiens_hsa041460.38067490
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36970643
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35947360
146Long-term depression_Homo sapiens_hsa047300.35426256

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