PAX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* developmental pigmentation (GO:0048066)6.84822824
2neuronal stem cell maintenance (GO:0097150)6.69914291
3* spinal cord association neuron differentiation (GO:0021527)5.75488809
4phenol-containing compound biosynthetic process (GO:0046189)5.62498035
5suckling behavior (GO:0001967)5.29042953
6secondary metabolic process (GO:0019748)4.97336027
7pyrimidine nucleobase catabolic process (GO:0006208)4.88992540
8Notch signaling involved in heart development (GO:0061314)4.73414295
9lens fiber cell development (GO:0070307)4.67134738
10tyrosine metabolic process (GO:0006570)4.49937994
11melanocyte differentiation (GO:0030318)4.07341141
12positive regulation of Notch signaling pathway (GO:0045747)4.06736594
13nephron tubule development (GO:0072080)4.04578547
14mesenchymal-epithelial cell signaling (GO:0060638)3.93216649
15auditory receptor cell differentiation (GO:0042491)3.84883852
16retinal ganglion cell axon guidance (GO:0031290)3.75975295
17multicellular organismal aging (GO:0010259)3.68176982
18pigment cell differentiation (GO:0050931)3.67563469
19forebrain neuron differentiation (GO:0021879)3.67487506
20cell surface receptor signaling pathway involved in heart development (GO:0061311)3.63486674
21nucleobase catabolic process (GO:0046113)3.62582271
22renal tubule development (GO:0061326)3.56181661
23positive regulation of neuroblast proliferation (GO:0002052)3.54430193
24* pigmentation (GO:0043473)3.50332596
25neuroepithelial cell differentiation (GO:0060563)3.44231567
26camera-type eye morphogenesis (GO:0048593)3.35623464
27postsynaptic membrane organization (GO:0001941)3.34138737
28response to pheromone (GO:0019236)3.33612113
29negative regulation of oligodendrocyte differentiation (GO:0048715)3.27429758
30daunorubicin metabolic process (GO:0044597)3.24940616
31polyketide metabolic process (GO:0030638)3.24940616
32doxorubicin metabolic process (GO:0044598)3.24940616
33pigment biosynthetic process (GO:0046148)3.23990110
34axonal fasciculation (GO:0007413)3.23080610
35limb development (GO:0060173)3.22517160
36appendage development (GO:0048736)3.22517160
37establishment of planar polarity (GO:0001736)3.15462523
38establishment of tissue polarity (GO:0007164)3.15462523
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.14821634
40cerebral cortex radially oriented cell migration (GO:0021799)3.11054552
41facial nerve structural organization (GO:0021612)3.09536545
42nonmotile primary cilium assembly (GO:0035058)3.07675793
43cornea development in camera-type eye (GO:0061303)3.06244740
44radial glial cell differentiation (GO:0060019)3.06057362
45cell proliferation in forebrain (GO:0021846)3.04729976
46DNA integration (GO:0015074)3.03781301
47sympathetic nervous system development (GO:0048485)3.03134452
48proximal/distal pattern formation (GO:0009954)3.03100313
49calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.02041154
50negative regulation of anoikis (GO:2000811)2.96530317
51ganglion development (GO:0061548)2.96261345
52neuron fate specification (GO:0048665)2.96189198
53cranial nerve development (GO:0021545)2.95507906
54mesenchymal cell development (GO:0014031)2.95047029
55regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94606982
56pigment granule organization (GO:0048753)2.93691844
57hair cell differentiation (GO:0035315)2.93265221
58head development (GO:0060322)2.92554560
59mesenchymal cell differentiation involved in kidney development (GO:0072161)2.92455121
60mesenchymal cell differentiation involved in renal system development (GO:2001012)2.92455121
61melanosome organization (GO:0032438)2.88552522
62nephron epithelium development (GO:0072009)2.88235169
63epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.86089912
64establishment of mitochondrion localization (GO:0051654)2.84690501
65regulation of non-canonical Wnt signaling pathway (GO:2000050)2.84560978
66cell migration in hindbrain (GO:0021535)2.82574569
67spinal cord development (GO:0021510)2.82536617
68neuron recognition (GO:0008038)2.82296384
69central nervous system neuron development (GO:0021954)2.80813983
70somatic stem cell division (GO:0048103)2.77363961
71lens morphogenesis in camera-type eye (GO:0002089)2.77085581
72lateral sprouting from an epithelium (GO:0060601)2.76891254
73outer ear morphogenesis (GO:0042473)2.76690999
74regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.76320831
75cranial nerve morphogenesis (GO:0021602)2.75822610
76negative regulation of stem cell proliferation (GO:2000647)2.74345316
77embryonic body morphogenesis (GO:0010172)2.74098705
78embryonic forelimb morphogenesis (GO:0035115)2.73998591
79embryonic retina morphogenesis in camera-type eye (GO:0060059)2.73376850
80regulation of neuroblast proliferation (GO:1902692)2.72486392
81intraciliary transport (GO:0042073)2.70205502
82limb bud formation (GO:0060174)2.70056909
83Notch receptor processing (GO:0007220)2.69855116
84positive regulation of vascular permeability (GO:0043117)2.69762638
85microtubule depolymerization (GO:0007019)2.69239262
86startle response (GO:0001964)2.68751605
87enteric nervous system development (GO:0048484)2.68500159
88extracellular negative regulation of signal transduction (GO:1900116)2.68401049
89extracellular regulation of signal transduction (GO:1900115)2.68401049
90morphogenesis of an epithelial sheet (GO:0002011)2.67335005
91negative regulation of axon guidance (GO:1902668)2.66920081
92stem cell development (GO:0048864)2.65506887
93negative regulation of axon extension involved in axon guidance (GO:0048843)2.65133846
94cranial nerve structural organization (GO:0021604)2.64985667
95DNA double-strand break processing (GO:0000729)2.64048919
96bone remodeling (GO:0046849)2.63427897
97inner ear receptor stereocilium organization (GO:0060122)2.63139037
98dendritic spine morphogenesis (GO:0060997)2.62631286
99negative chemotaxis (GO:0050919)2.62466475
100negative regulation of leukocyte chemotaxis (GO:0002689)2.61500281
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61047653
102* cell differentiation in spinal cord (GO:0021515)2.60995689
103peptidyl-arginine N-methylation (GO:0035246)2.60910266
104peptidyl-arginine methylation (GO:0018216)2.60910266
105midbrain development (GO:0030901)2.59344298
106transmission of nerve impulse (GO:0019226)2.59017899
107hippocampus development (GO:0021766)2.57206763
108regulation of axon extension involved in axon guidance (GO:0048841)2.55462691
109forebrain neuron development (GO:0021884)2.54976071
110inner ear receptor cell differentiation (GO:0060113)2.54767140
111negative regulation of mast cell activation (GO:0033004)2.53726056
112response to folic acid (GO:0051593)2.53299977
113dendrite morphogenesis (GO:0048813)2.53190310
114post-anal tail morphogenesis (GO:0036342)2.52066245
115digestive tract morphogenesis (GO:0048546)2.51924477
116peptidyl-arginine omega-N-methylation (GO:0035247)2.51309759
117apical protein localization (GO:0045176)2.50504988
118forelimb morphogenesis (GO:0035136)2.50378367
119segment specification (GO:0007379)2.49871700
120regulation of DNA endoreduplication (GO:0032875)2.49632671
121cerebral cortex development (GO:0021987)2.49608233
122protein K6-linked ubiquitination (GO:0085020)2.49351104
123mesenchymal cell differentiation (GO:0048762)2.47653282
124regulation of pigment cell differentiation (GO:0050932)2.47012021
125neural crest cell development (GO:0014032)2.44912486
126embryonic limb morphogenesis (GO:0030326)2.42862675
127embryonic appendage morphogenesis (GO:0035113)2.42862675
128presynaptic membrane assembly (GO:0097105)2.42201683
129mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.41585928
130pigment metabolic process (GO:0042440)2.40795473
131Rap protein signal transduction (GO:0032486)2.38593955
132positive regulation of DNA-dependent DNA replication (GO:2000105)2.35573735
133central nervous system projection neuron axonogenesis (GO:0021952)2.35472684
134myotube differentiation (GO:0014902)2.34755454
135tongue development (GO:0043586)2.34257734
136embryonic skeletal system morphogenesis (GO:0048704)2.34067950
137columnar/cuboidal epithelial cell differentiation (GO:0002065)2.34017603
138regulation of timing of cell differentiation (GO:0048505)2.33774550
139regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31247403
140regulation of mitotic spindle checkpoint (GO:1903504)2.31247403
141presynaptic membrane organization (GO:0097090)2.30131964
142palate development (GO:0060021)2.28834240
143pyrimidine dimer repair (GO:0006290)2.28181756
144metanephric mesenchyme development (GO:0072075)2.27897839
145negative regulation of keratinocyte proliferation (GO:0010839)2.27459254
146atrial cardiac muscle cell action potential (GO:0086014)2.26993253
147regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.26736592
148mesenchyme morphogenesis (GO:0072132)2.26512837
149paraxial mesoderm development (GO:0048339)2.25851573
150regulation of development, heterochronic (GO:0040034)2.25357045
151embryonic digit morphogenesis (GO:0042733)2.24662962
152regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.24329801
153anatomical structure arrangement (GO:0048532)2.24018861
154regulation of centriole replication (GO:0046599)2.23687777
155positive regulation of neural precursor cell proliferation (GO:2000179)2.22077928
156phenol-containing compound metabolic process (GO:0018958)2.21077640
157negative regulation of myoblast differentiation (GO:0045662)2.20616891
158appendage morphogenesis (GO:0035107)2.19686179
159limb morphogenesis (GO:0035108)2.19686179
160kinetochore assembly (GO:0051382)2.18892832
161interkinetic nuclear migration (GO:0022027)2.17217109
162middle ear morphogenesis (GO:0042474)2.16806709
163positive regulation of stem cell proliferation (GO:2000648)2.16284569
164cell differentiation involved in metanephros development (GO:0072202)2.16267061
165embryonic cranial skeleton morphogenesis (GO:0048701)2.14785225
166artery development (GO:0060840)2.13103477
167melanin biosynthetic process (GO:0042438)15.5802537
168melanin metabolic process (GO:0006582)14.5243018
169secondary metabolite biosynthetic process (GO:0044550)12.8428460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.35638646
2EZH2_22144423_ChIP-Seq_EOC_Human3.55064092
3GBX2_23144817_ChIP-Seq_PC3_Human3.31107488
4* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84804912
5TP63_19390658_ChIP-ChIP_HaCaT_Human2.63430618
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61962192
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49342371
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38081190
9FUS_26573619_Chip-Seq_HEK293_Human2.36308880
10* CBX2_27304074_Chip-Seq_ESCs_Mouse2.34714941
11* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.33413681
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32237876
13EWS_26573619_Chip-Seq_HEK293_Human2.18193151
14* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12389551
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09766561
16TAF15_26573619_Chip-Seq_HEK293_Human2.04372400
17* FLI1_27457419_Chip-Seq_LIVER_Mouse1.96959498
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95623064
19* EZH2_27304074_Chip-Seq_ESCs_Mouse1.93311693
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92939986
21P300_19829295_ChIP-Seq_ESCs_Human1.92859585
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.90671330
23* EED_16625203_ChIP-ChIP_MESCs_Mouse1.90260002
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.85449078
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.85141165
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.83545048
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83037051
28* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82168684
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80565540
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78301720
31* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.78207013
32* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76083921
33* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75909505
34* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75163171
35SOX2_16153702_ChIP-ChIP_HESCs_Human1.73743141
36ER_23166858_ChIP-Seq_MCF-7_Human1.69832616
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69831669
38* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68678174
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.67843737
40* RNF2_27304074_Chip-Seq_NSC_Mouse1.67633766
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66894950
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65597112
43* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65575101
44* NANOG_18555785_Chip-Seq_ESCs_Mouse1.64647156
45* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.63092798
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61362066
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.60940630
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60252987
49* RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58518494
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.57676709
51* NFE2_27457419_Chip-Seq_LIVER_Mouse1.56987403
52* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56524110
53* RING1B_27294783_Chip-Seq_ESCs_Mouse1.55284379
54* E2F1_18555785_Chip-Seq_ESCs_Mouse1.54723479
55CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.53808533
56* P53_22387025_ChIP-Seq_ESCs_Mouse1.52242887
57E2F7_22180533_ChIP-Seq_HELA_Human1.52194479
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49382346
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47754350
60TP53_18474530_ChIP-ChIP_U2OS_Human1.47515296
61* EZH2_27294783_Chip-Seq_ESCs_Mouse1.46045654
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44759401
63* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42526880
64* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.42142173
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41652327
66* ISL1_27105846_Chip-Seq_CPCs_Mouse1.40255725
67* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40144677
68* EZH2_27294783_Chip-Seq_NPCs_Mouse1.39680819
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39155666
70* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38550434
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38405507
72* RNF2_27304074_Chip-Seq_ESCs_Mouse1.37896528
73* CMYC_18555785_Chip-Seq_ESCs_Mouse1.37830681
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.37567377
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36568582
76* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35143272
77* P300_18555785_Chip-Seq_ESCs_Mouse1.34860659
78* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34125039
79* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33030238
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32796923
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31952725
82IGF1R_20145208_ChIP-Seq_DFB_Human1.31346084
83* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.30653034
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.30515845
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30511587
86* TP53_20018659_ChIP-ChIP_R1E_Mouse1.29769062
87* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29529153
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29245799
89* STAT3_18555785_Chip-Seq_ESCs_Mouse1.28730962
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28668612
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28668612
92* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28506135
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27191169
94VDR_22108803_ChIP-Seq_LS180_Human1.26727156
95* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26409381
96* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26409381
97* NMYC_18555785_Chip-Seq_ESCs_Mouse1.25495612
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25233513
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24600832
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23335522
101* WT1_19549856_ChIP-ChIP_CCG9911_Human1.22821041
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21620373
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20878259
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20566275
105* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20550005
106POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.19749791
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19071002
108* RING1B_27294783_Chip-Seq_NPCs_Mouse1.18867630
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17876963
110* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17775420
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16270430
112SOX9_26525672_Chip-Seq_HEART_Mouse1.15365205
113AR_25329375_ChIP-Seq_VCAP_Human1.14003669
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13584333
115* SOX2_18555785_Chip-Seq_ESCs_Mouse1.11744514
116* RUNX2_22187159_ChIP-Seq_PCA_Human1.10539276
117* ZFX_18555785_Chip-Seq_ESCs_Mouse1.10390115
118* STAT3_23295773_ChIP-Seq_U87_Human1.10358087
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10126387
120IRF1_19129219_ChIP-ChIP_H3396_Human1.09968474
121JUN_21703547_ChIP-Seq_K562_Human1.09899625
122* GF1B_26923725_Chip-Seq_HPCs_Mouse1.09604761
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05682956
124* OCT4_18555785_Chip-Seq_ESCs_Mouse1.05586121
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05030075
126* PU1_27457419_Chip-Seq_LIVER_Mouse1.04767911
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03004832
128KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03004832
129KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03004832
130MYC_18940864_ChIP-ChIP_HL60_Human1.02362216
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01751231
132ZNF274_21170338_ChIP-Seq_K562_Hela1.01353351
133* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00589168
134* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99579143
135TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99012307
136TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98878597
137* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98530197
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97921800
139REST_21632747_ChIP-Seq_MESCs_Mouse0.97771271
140TP53_16413492_ChIP-PET_HCT116_Human0.95601502
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92648497
142POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92141232
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92031552
144RUNX1_26923725_Chip-Seq_HPCs_Mouse0.92010335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation8.16349178
2* MP0005171_absent_coat_pigmentation6.32217735
3MP0003136_yellow_coat_color4.80579412
4MP0005408_hypopigmentation4.11088203
5MP0004381_abnormal_hair_follicle3.79864363
6MP0005257_abnormal_intraocular_pressure3.01132949
7MP0002102_abnormal_ear_morphology2.92757207
8MP0000015_abnormal_ear_pigmentation2.85724699
9MP0005377_hearing/vestibular/ear_phenot2.66037692
10MP0003878_abnormal_ear_physiology2.66037692
11MP0000371_diluted_coat_color2.63883784
12* MP0002095_abnormal_skin_pigmentation2.59135377
13MP0000566_synostosis2.51866631
14MP0002653_abnormal_ependyma_morphology2.39561823
15* MP0002938_white_spotting2.33278206
16MP0006292_abnormal_olfactory_placode2.26899195
17MP0005075_abnormal_melanosome_morpholog2.22893452
18MP0001324_abnormal_eye_pigmentation2.19464560
19MP0000569_abnormal_digit_pigmentation2.18995275
20MP0005248_abnormal_Harderian_gland2.04929452
21MP0004133_heterotaxia2.01871634
22MP0005174_abnormal_tail_pigmentation1.87424006
23* MP0002075_abnormal_coat/hair_pigmentati1.85088422
24* MP0001186_pigmentation_phenotype1.77339842
25MP0006072_abnormal_retinal_apoptosis1.73903970
26MP0005423_abnormal_somatic_nervous1.73867780
27MP0005409_darkened_coat_color1.73708844
28MP0009697_abnormal_copulation1.71041990
29MP0002638_abnormal_pupillary_reflex1.59549394
30MP0009250_abnormal_appendicular_skeleto1.57475566
31MP0001188_hyperpigmentation1.55895718
32MP0004859_abnormal_synaptic_plasticity1.50132153
33MP0002877_abnormal_melanocyte_morpholog1.41744779
34MP0005503_abnormal_tendon_morphology1.40212145
35MP0002249_abnormal_larynx_morphology1.38858272
36MP0003122_maternal_imprinting1.30547421
37MP0010030_abnormal_orbit_morphology1.30331158
38* MP0000955_abnormal_spinal_cord1.29391999
39MP0003121_genomic_imprinting1.29337175
40MP0000049_abnormal_middle_ear1.28702631
41MP0004858_abnormal_nervous_system1.28648850
42MP0003937_abnormal_limbs/digits/tail_de1.28438364
43* MP0003385_abnormal_body_wall1.25319484
44MP0003787_abnormal_imprinting1.22291984
45MP0002735_abnormal_chemical_nociception1.15974992
46MP0005197_abnormal_uvea_morphology1.15131901
47MP0002177_abnormal_outer_ear1.13554418
48* MP0000762_abnormal_tongue_morphology1.11684335
49MP0003755_abnormal_palate_morphology1.10947532
50* MP0003861_abnormal_nervous_system1.10225542
51MP0002822_catalepsy1.09110906
52MP0004885_abnormal_endolymph1.06431852
53MP0010094_abnormal_chromosome_stability1.04495924
54MP0004272_abnormal_basement_membrane1.02394678
55* MP0001293_anophthalmia1.01715444
56* MP0002752_abnormal_somatic_nervous1.00676723
57MP0001299_abnormal_eye_distance/0.99775846
58MP0001346_abnormal_lacrimal_gland0.98415254
59MP0005645_abnormal_hypothalamus_physiol0.97497210
60MP0008789_abnormal_olfactory_epithelium0.97077399
61MP0000579_abnormal_nail_morphology0.94396494
62MP0001485_abnormal_pinna_reflex0.94306092
63* MP0002882_abnormal_neuron_morphology0.93787110
64MP0000534_abnormal_ureter_morphology0.91852783
65* MP0002152_abnormal_brain_morphology0.91604864
66MP0009053_abnormal_anal_canal0.91172354
67MP0005187_abnormal_penis_morphology0.89158462
68* MP0002233_abnormal_nose_morphology0.87513303
69MP0000537_abnormal_urethra_morphology0.87173294
70MP0002163_abnormal_gland_morphology0.86647429
71MP0002928_abnormal_bile_duct0.86462654
72MP0003942_abnormal_urinary_system0.85283346
73MP0002751_abnormal_autonomic_nervous0.85217069
74MP0005195_abnormal_posterior_eye0.83389637
75* MP0002116_abnormal_craniofacial_bone0.79151670
76* MP0002092_abnormal_eye_morphology0.77203741
77MP0008438_abnormal_cutaneous_collagen0.76678046
78MP0000631_abnormal_neuroendocrine_gland0.76659618
79* MP0000026_abnormal_inner_ear0.75947995
80* MP0002084_abnormal_developmental_patter0.75196733
81MP0005646_abnormal_pituitary_gland0.74960179
82* MP0002109_abnormal_limb_morphology0.74747460
83MP0000778_abnormal_nervous_system0.74150505
84MP0003880_abnormal_central_pattern0.74088087
85MP0008007_abnormal_cellular_replicative0.74042663
86MP0000647_abnormal_sebaceous_gland0.73480536
87MP0003941_abnormal_skin_development0.72596844
88MP0004811_abnormal_neuron_physiology0.72267988
89* MP0000432_abnormal_head_morphology0.72128656
90MP0002132_abnormal_respiratory_system0.71024009
91* MP0003935_abnormal_craniofacial_develop0.70923400
92MP0000678_abnormal_parathyroid_gland0.70755288
93MP0008058_abnormal_DNA_repair0.70720413
94MP0002090_abnormal_vision0.69421804
95MP0005508_abnormal_skeleton_morphology0.69261107
96* MP0002111_abnormal_tail_morphology0.68779177
97* MP0008932_abnormal_embryonic_tissue0.68701326
98MP0005253_abnormal_eye_physiology0.66994496
99MP0002067_abnormal_sensory_capabilities0.66912433
100MP0008057_abnormal_DNA_replication0.66087432
101MP0004134_abnormal_chest_morphology0.66032815
102MP0001286_abnormal_eye_development0.66011967
103MP0004742_abnormal_vestibular_system0.65567735
104* MP0003938_abnormal_ear_development0.64595234
105MP0005499_abnormal_olfactory_system0.64245227
106MP0005394_taste/olfaction_phenotype0.64245227
107MP0008961_abnormal_basal_metabolism0.63893412
108MP0006276_abnormal_autonomic_nervous0.63761091
109* MP0000733_abnormal_muscle_development0.63033905
110MP0004142_abnormal_muscle_tone0.62452588
111MP0003634_abnormal_glial_cell0.61325979
112MP0002184_abnormal_innervation0.61282015
113MP0000383_abnormal_hair_follicle0.60768505
114MP0003943_abnormal_hepatobiliary_system0.59486302
115MP0003111_abnormal_nucleus_morphology0.56858002
116* MP0002932_abnormal_joint_morphology0.56741501
117MP0005367_renal/urinary_system_phenotyp0.56431344
118MP0000516_abnormal_urinary_system0.56431344
119MP0000163_abnormal_cartilage_morphology0.54945630
120* MP0002114_abnormal_axial_skeleton0.54234372
121MP0005379_endocrine/exocrine_gland_phen0.53740810
122MP0001963_abnormal_hearing_physiology0.53577187
123MP0000428_abnormal_craniofacial_morphol0.52817940
124MP0002557_abnormal_social/conspecific_i0.52070090
125* MP0005391_vision/eye_phenotype0.51146711
126MP0001486_abnormal_startle_reflex0.51067870
127MP0001270_distended_abdomen0.51052602
128MP0000613_abnormal_salivary_gland0.49492159
129MP0002282_abnormal_trachea_morphology0.49341978
130MP0001984_abnormal_olfaction0.49319007
131MP0001340_abnormal_eyelid_morphology0.49049731
132MP0002697_abnormal_eye_size0.47862158
133* MP0002113_abnormal_skeleton_development0.47302579
134MP0001529_abnormal_vocalization0.46078191
135MP0002115_abnormal_skeleton_extremities0.45223148

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the fovea (HP:0008060)6.85548356
2Hypoplasia of the fovea (HP:0007750)6.85548356
3Aplasia/Hypoplasia of the macula (HP:0008059)6.59605963
4Aplasia/Hypoplasia affecting the retina (HP:0008061)6.03815026
5* Blue irides (HP:0000635)5.58009003
6Abnormality of the fovea (HP:0000493)5.40544276
7* White forelock (HP:0002211)4.47463603
8* Patchy hypopigmentation of hair (HP:0011365)4.39267309
9Ocular albinism (HP:0001107)4.38602975
10Iris hypopigmentation (HP:0007730)3.88672810
11Vertebral arch anomaly (HP:0008438)3.69737342
12Oligodactyly (HP:0012165)3.43012945
13Rib fusion (HP:0000902)3.36836329
14Hemivertebrae (HP:0002937)3.35635252
15Absent eyebrow (HP:0002223)3.32459257
16Generalized hypopigmentation (HP:0007513)3.23913559
17* Congenital sensorineural hearing impairment (HP:0008527)3.22548269
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10184998
19Generalized hypopigmentation of hair (HP:0011358)3.06129165
20Peripheral hypomyelination (HP:0007182)2.93864125
21Chromsome breakage (HP:0040012)2.84934800
22Vitreoretinal degeneration (HP:0000655)2.81559007
23Midline defect of the nose (HP:0004122)2.77271013
24Chorioretinal atrophy (HP:0000533)2.75818129
25Oligodactyly (hands) (HP:0001180)2.75291802
26Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.73282845
27Hypopigmentation of the fundus (HP:0007894)2.67372955
28Abnormality of the 4th metacarpal (HP:0010012)2.66757796
29Trigonocephaly (HP:0000243)2.66308912
30Abnormality of the parietal bone (HP:0002696)2.65264892
31Absent epiphyses (HP:0010577)2.65058369
32Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.65058369
33High anterior hairline (HP:0009890)2.62734051
34Abnormality of the renal collecting system (HP:0004742)2.59559768
35Subacute progressive viral hepatitis (HP:0006572)2.59154643
36Abnormality of the ischium (HP:0003174)2.59029028
37Abnormality of the labia minora (HP:0012880)2.56641390
38Morphological abnormality of the inner ear (HP:0011390)2.54267355
39Chronic hepatic failure (HP:0100626)2.52909666
40Hypoplasia of the ulna (HP:0003022)2.51633658
41Anterior segment dysgenesis (HP:0007700)2.50950943
42Abnormality of incisor morphology (HP:0011063)2.49842422
43Aplasia cutis congenita (HP:0001057)2.48268567
44Renal hypoplasia (HP:0000089)2.48057476
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44983286
46Short 4th metacarpal (HP:0010044)2.44983286
47Parakeratosis (HP:0001036)2.42917898
48Duplicated collecting system (HP:0000081)2.37653023
49Pulmonary artery stenosis (HP:0004415)2.33004583
50Neonatal short-limb short stature (HP:0008921)2.31864880
51Intestinal atresia (HP:0011100)2.27939897
52Abnormal auditory evoked potentials (HP:0006958)2.25883867
53Hypoplastic ischia (HP:0003175)2.25545621
54Ectopic kidney (HP:0000086)2.23650109
55Microglossia (HP:0000171)2.23076764
56Breech presentation (HP:0001623)2.21616204
57True hermaphroditism (HP:0010459)2.18490069
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.17714952
59Freckling (HP:0001480)2.14976568
60Abnormality of the incisor (HP:0000676)2.14601196
61Coarctation of aorta (HP:0001680)2.14279619
62* Heterochromia iridis (HP:0001100)2.12581830
63Abnormality of the nasolacrimal system (HP:0000614)2.12515492
64* Premature graying of hair (HP:0002216)2.12139720
65Facial cleft (HP:0002006)2.06240422
66Abnormality of the phalanges of the hallux (HP:0010057)2.05345561
67Adrenal hypoplasia (HP:0000835)2.03673772
68Aplasia/Hypoplasia of the ulna (HP:0006495)2.03586491
69Aplasia involving bones of the upper limbs (HP:0009823)2.03346743
70Aplasia of the phalanges of the hand (HP:0009802)2.03346743
71Aplasia involving bones of the extremities (HP:0009825)2.03346743
72Bilateral sensorineural hearing impairment (HP:0008619)2.03116936
73Aplasia/Hypoplasia of the tongue (HP:0010295)2.01242420
74Esophageal atresia (HP:0002032)2.00403156
75* Cutaneous finger syndactyly (HP:0010554)2.00214757
76Supernumerary spleens (HP:0009799)2.00070445
77Bell-shaped thorax (HP:0001591)2.00053379
78Short middle phalanx of the 5th finger (HP:0004220)1.98085767
79Abnormality of dentin (HP:0010299)1.96933895
80Morphological abnormality of the middle ear (HP:0008609)1.96874126
81Pancreatic fibrosis (HP:0100732)1.96173339
82Aqueductal stenosis (HP:0002410)1.93854000
83Abnormality of the hip-girdle musculature (HP:0001445)1.90340009
84Abnormality of the musculature of the pelvis (HP:0001469)1.90340009
85Absent hair (HP:0002298)1.90252420
86Ulnar claw (HP:0001178)1.90234188
87Submucous cleft hard palate (HP:0000176)1.90050264
88Albinism (HP:0001022)1.89877773
89Abnormality of the aortic arch (HP:0012303)1.89018123
90Increased number of teeth (HP:0011069)1.86531121
91* Hypoplasia of the iris (HP:0007676)1.86160885
92Split foot (HP:0001839)1.85977091
93Nasolacrimal duct obstruction (HP:0000579)1.84363455
94Conical tooth (HP:0000698)1.84277255
95Anencephaly (HP:0002323)1.83989488
96Intellectual disability, moderate (HP:0002342)1.83731711
97Abnormal hair whorl (HP:0010721)1.83665683
98Renal dysplasia (HP:0000110)1.83633275
99* Cutaneous syndactyly (HP:0012725)1.83359589
100Gait imbalance (HP:0002141)1.82525743
101Decreased lacrimation (HP:0000633)1.82400017
102Nephroblastoma (Wilms tumor) (HP:0002667)1.81555939
103Alacrima (HP:0000522)1.81036528
104Preaxial hand polydactyly (HP:0001177)1.80107684
105Postaxial hand polydactyly (HP:0001162)1.79551329
106Congenital primary aphakia (HP:0007707)1.79184902
107Termporal pattern (HP:0011008)1.77498759
108Insidious onset (HP:0003587)1.77498759
109Embryonal renal neoplasm (HP:0011794)1.77254806
110Gastrointestinal atresia (HP:0002589)1.76303416
111Papillary thyroid carcinoma (HP:0002895)1.75980188
112Anal atresia (HP:0002023)1.75371834
113Postaxial foot polydactyly (HP:0001830)1.75075327
114Protruding tongue (HP:0010808)1.74891790
115Astigmatism (HP:0000483)1.74514035
116Vaginal atresia (HP:0000148)1.74040634
117Wide anterior fontanel (HP:0000260)1.73852856
118Abnormality of the septum pellucidum (HP:0007375)1.73837503
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73546115
120Calcaneovalgus deformity (HP:0001848)1.72319977
121Genital tract atresia (HP:0001827)1.71818703
122Febrile seizures (HP:0002373)1.71569385
123Meckel diverticulum (HP:0002245)1.71469979
124Abnormality of the nasal septum (HP:0000419)1.71218475
125Abnormality of chromosome stability (HP:0003220)1.71088194
126Hypothermia (HP:0002045)1.70542956
127Abnormality of the intervertebral disk (HP:0005108)1.69445956
128Abnormality of the lacrimal duct (HP:0011481)1.69390284
129* Synostosis of carpal bones (HP:0005048)1.68694966
130Thin ribs (HP:0000883)1.68613854
131Molar tooth sign on MRI (HP:0002419)1.67413113
132Abnormality of midbrain morphology (HP:0002418)1.67413113
133Prostate neoplasm (HP:0100787)1.67381864
134Hepatoblastoma (HP:0002884)1.67150816
135Abnormality of the anterior chamber (HP:0000593)1.66463785
136Genetic anticipation (HP:0003743)1.64708189
137Abnormal number of incisors (HP:0011064)1.64070596
138Hypoplastic pelvis (HP:0008839)1.63973593
139* Aganglionic megacolon (HP:0002251)1.63001350
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.62354503
141Abnormality of the ileum (HP:0001549)1.62231181
142Anomalous pulmonary venous return (HP:0010772)1.62105607
143Cystic liver disease (HP:0006706)1.61994143
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.61724714
145Neoplasm of the adrenal cortex (HP:0100641)1.60655729
146Abnormality of the diencephalon (HP:0010662)1.60360056
147Deformed tarsal bones (HP:0008119)1.60215190
148Broad foot (HP:0001769)1.59655298
149Long clavicles (HP:0000890)1.59098280
150Diastasis recti (HP:0001540)1.58561283
151Nephronophthisis (HP:0000090)1.58440648
152Small hand (HP:0200055)1.58066379
153Tubulointerstitial nephritis (HP:0001970)1.56739533
154Cupped ear (HP:0000378)1.55608570
155Abnormal lung lobation (HP:0002101)1.54125186
156Syringomyelia (HP:0003396)1.52374058
157Spinal cord lesions (HP:0100561)1.52374058
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.52022029
159Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.52002614
160Abnormality of the preputium (HP:0100587)1.51781899
161Occipital encephalocele (HP:0002085)1.51504217
162Volvulus (HP:0002580)1.51097264
163Medial flaring of the eyebrow (HP:0010747)1.50587797
164Optic nerve hypoplasia (HP:0000609)1.50255439
165Mesomelia (HP:0003027)1.49742040
166Microtia (HP:0008551)1.46496682
167Absent septum pellucidum (HP:0001331)1.46317959
168Viral hepatitis (HP:0006562)1.46173294
169Anophthalmia (HP:0000528)1.45817454
170Abnormality of the phalanges of the 5th finger (HP:0004213)1.45537004

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.56822188
2CASK4.14927592
3PAK63.45065780
4STK163.03667575
5MKNK12.99662504
6MKNK22.88425625
7MET2.57784890
8TNIK2.39090749
9EPHA32.35292882
10ERBB32.30947662
11MAP3K42.30920307
12MARK32.18594793
13ZAK2.17321926
14MOS2.11586232
15SRPK12.03874350
16SIK32.01942975
17FGFR22.00439267
18WEE11.93106555
19CDK191.85332876
20PRPF4B1.68531745
21WNK31.65072910
22BMPR1B1.64441694
23PNCK1.64100689
24MUSK1.57142501
25BMPR21.56972446
26NTRK11.56646298
27BMX1.55944860
28CDK81.48206075
29KSR11.46348267
30AKT31.46245663
31PLK41.43799572
32PLK21.37302478
33EIF2AK21.33442119
34CDC71.31990210
35NEK21.29495840
36CSNK1A1L1.28929771
37MAPK131.27315904
38PAK31.26860250
39CLK11.26572159
40CDK31.24374348
41YES11.22468787
42ADRBK21.15937291
43MAP4K21.15840318
44PINK11.15200304
45FGFR11.13963630
46NEK61.12252920
47STK38L1.10441420
48TRIM281.09290005
49TYRO31.08821185
50EPHB11.07135220
51CAMK1G1.05998804
52CSNK1G11.05153877
53PRKD31.02647037
54SGK21.02453380
55VRK11.01606948
56CSNK1G31.00011936
57BRD40.99030773
58LATS10.95140679
59NEK10.93901841
60GRK70.93585744
61TXK0.92061207
62DDR20.91463739
63CDK70.90410267
64LATS20.89217576
65DYRK30.87119524
66DYRK1B0.83855692
67KSR20.82880214
68PRKCG0.82566905
69PLK30.82312078
70NUAK10.81952366
71CDK11A0.80408906
72CDK180.80279057
73CHEK20.79693854
74PRKCE0.79188864
75MAPK150.78616933
76ATR0.77613780
77IRAK10.76993070
78PBK0.76276216
79CDK150.75680268
80IRAK40.75611896
81MAP2K70.75200250
82AKT20.73234557
83DYRK20.70938077
84BRAF0.70900844
85RPS6KA40.70779802
86CDK120.68865358
87ROCK20.65764315
88RAF10.65513729
89CDK140.64817094
90TAOK20.63489230
91RPS6KA50.61482060
92CCNB10.61217303
93CDK50.60527056
94PDK20.58359238
95EIF2AK30.57870054
96PAK20.56911531
97BCR0.56475869
98PDGFRA0.55608224
99BUB10.54298643
100EPHB20.54247612
101SGK4940.53293967
102SGK2230.53293967
103CSNK1G20.52989611
104TTK0.52577439
105TSSK60.51949493
106PRKG20.50763267
107PRKACB0.49978842
108LMTK20.49244811
109ATM0.49200174
110CAMK2B0.47650671
111BRSK20.47197916
112TGFBR10.45586693
113PASK0.45454721
114CDK60.44544686
115MAP3K120.44178573
116STK240.43541224
117MAP2K40.42485795
118MAPK70.42064622
119NLK0.41685031
120SIK20.41623676
121INSRR0.40717059
122ERBB20.40698127
123STK30.40330604
124ADRBK10.40153040
125MAP3K140.39555468
126MARK10.38966680
127MINK10.37327722
128UHMK10.36753343
129ICK0.36484933
130PRKDC0.36231159
131IRAK30.36030596
132NEK90.35798263
133PKN20.35792997
134SGK30.33606249
135PKN10.33256060
136MAPKAPK50.32802921
137LYN0.32601663
138AKT10.31999817
139DYRK1A0.31195710
140GSK3A0.30780383
141PLK10.30551985
142EPHA40.29892053
143STK390.29831039
144GRK10.29657096
145IRAK20.28598857
146NTRK20.28484995
147FER0.27752260
148CAMK2A0.26686423
149CDK10.26340197
150STK40.25194831
151CAMK2D0.24638450
152OXSR10.23725367

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.86148760
2Tyrosine metabolism_Homo sapiens_hsa003502.80759787
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47723796
4Homologous recombination_Homo sapiens_hsa034402.34469197
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84449257
6Propanoate metabolism_Homo sapiens_hsa006401.81921148
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78023846
8Basal transcription factors_Homo sapiens_hsa030221.70944019
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.67501007
10Basal cell carcinoma_Homo sapiens_hsa052171.67114096
11Axon guidance_Homo sapiens_hsa043601.65131681
12Protein export_Homo sapiens_hsa030601.64494534
13Melanogenesis_Homo sapiens_hsa049161.64418252
14Lysine degradation_Homo sapiens_hsa003101.63389569
15Non-homologous end-joining_Homo sapiens_hsa034501.62839637
16Nucleotide excision repair_Homo sapiens_hsa034201.54709711
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54483447
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52370821
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.50752936
20Cell cycle_Homo sapiens_hsa041101.47670822
21Nicotine addiction_Homo sapiens_hsa050331.43161635
22DNA replication_Homo sapiens_hsa030301.40707032
23Sulfur relay system_Homo sapiens_hsa041221.39241478
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34678532
25Spliceosome_Homo sapiens_hsa030401.30742855
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30643520
27RNA degradation_Homo sapiens_hsa030181.29756235
28Melanoma_Homo sapiens_hsa052181.25388939
29RNA polymerase_Homo sapiens_hsa030201.25385643
30Autoimmune thyroid disease_Homo sapiens_hsa053201.21863563
31Butanoate metabolism_Homo sapiens_hsa006501.20924300
32Wnt signaling pathway_Homo sapiens_hsa043101.20470318
33Mismatch repair_Homo sapiens_hsa034301.20139099
34Sphingolipid metabolism_Homo sapiens_hsa006001.17425477
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15773850
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15241461
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13411429
38Colorectal cancer_Homo sapiens_hsa052101.12545699
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10590021
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09902891
41Serotonergic synapse_Homo sapiens_hsa047261.09503468
42Rheumatoid arthritis_Homo sapiens_hsa053231.09040286
43Ether lipid metabolism_Homo sapiens_hsa005651.07295707
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05615857
45Hedgehog signaling pathway_Homo sapiens_hsa043401.04858947
46Base excision repair_Homo sapiens_hsa034101.01069702
47Arachidonic acid metabolism_Homo sapiens_hsa005901.00341893
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99669401
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97711472
50Steroid biosynthesis_Homo sapiens_hsa001000.97484988
51Malaria_Homo sapiens_hsa051440.97131254
52Phototransduction_Homo sapiens_hsa047440.96595041
53Collecting duct acid secretion_Homo sapiens_hsa049660.92954411
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92509983
55Protein digestion and absorption_Homo sapiens_hsa049740.92235135
56Biosynthesis of amino acids_Homo sapiens_hsa012300.91727829
57Graft-versus-host disease_Homo sapiens_hsa053320.91355037
58MicroRNAs in cancer_Homo sapiens_hsa052060.88670736
59Taste transduction_Homo sapiens_hsa047420.87425473
60Cocaine addiction_Homo sapiens_hsa050300.87044362
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86344755
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86007916
63* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84415056
64Endometrial cancer_Homo sapiens_hsa052130.81927708
65Arginine and proline metabolism_Homo sapiens_hsa003300.80668527
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80591970
67Adherens junction_Homo sapiens_hsa045200.79515861
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79230324
69Gap junction_Homo sapiens_hsa045400.78977443
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77104379
71Oxidative phosphorylation_Homo sapiens_hsa001900.76972974
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76564781
73Herpes simplex infection_Homo sapiens_hsa051680.76301469
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76269743
75Morphine addiction_Homo sapiens_hsa050320.75457330
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73044453
77p53 signaling pathway_Homo sapiens_hsa041150.71113342
78N-Glycan biosynthesis_Homo sapiens_hsa005100.70927165
79Prostate cancer_Homo sapiens_hsa052150.70553442
80Pyrimidine metabolism_Homo sapiens_hsa002400.69848362
81Dopaminergic synapse_Homo sapiens_hsa047280.67716280
82mRNA surveillance pathway_Homo sapiens_hsa030150.67432592
83Purine metabolism_Homo sapiens_hsa002300.67189242
84Hippo signaling pathway_Homo sapiens_hsa043900.66812832
85GABAergic synapse_Homo sapiens_hsa047270.66753831
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66717726
87Phagosome_Homo sapiens_hsa041450.66562619
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66272506
89Measles_Homo sapiens_hsa051620.65026148
90Long-term depression_Homo sapiens_hsa047300.64401782
91Pathways in cancer_Homo sapiens_hsa052000.64028582
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.63831587
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63477291
94Alcoholism_Homo sapiens_hsa050340.63268449
95African trypanosomiasis_Homo sapiens_hsa051430.62089646
96Dilated cardiomyopathy_Homo sapiens_hsa054140.61936175
97Systemic lupus erythematosus_Homo sapiens_hsa053220.61688095
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60508400
99Tight junction_Homo sapiens_hsa045300.60469617
100Vibrio cholerae infection_Homo sapiens_hsa051100.60369535
101Circadian entrainment_Homo sapiens_hsa047130.60175500
102Notch signaling pathway_Homo sapiens_hsa043300.60052402
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59501195
104Oocyte meiosis_Homo sapiens_hsa041140.59268240
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.58814376
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58572682
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.57591679
108Ras signaling pathway_Homo sapiens_hsa040140.57470515
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57374885
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56226187
111Allograft rejection_Homo sapiens_hsa053300.55178260
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55115014
113ECM-receptor interaction_Homo sapiens_hsa045120.55038400
114Proteasome_Homo sapiens_hsa030500.54614490
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54555125
116HTLV-I infection_Homo sapiens_hsa051660.53895310
117Fructose and mannose metabolism_Homo sapiens_hsa000510.53892030
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53556299
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53431690
120Linoleic acid metabolism_Homo sapiens_hsa005910.53389452
121Hematopoietic cell lineage_Homo sapiens_hsa046400.53326709
122Cholinergic synapse_Homo sapiens_hsa047250.52401573
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51828169
124Glutamatergic synapse_Homo sapiens_hsa047240.50262450
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46782183
126Fatty acid elongation_Homo sapiens_hsa000620.46633367
127Huntingtons disease_Homo sapiens_hsa050160.46530842
128Cardiac muscle contraction_Homo sapiens_hsa042600.46476349
129Fatty acid metabolism_Homo sapiens_hsa012120.46390474
130RNA transport_Homo sapiens_hsa030130.46110398
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45897115
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.44855501
133Carbon metabolism_Homo sapiens_hsa012000.44112718
134Circadian rhythm_Homo sapiens_hsa047100.43657742
135TGF-beta signaling pathway_Homo sapiens_hsa043500.43381928
136Proteoglycans in cancer_Homo sapiens_hsa052050.42979548
137Small cell lung cancer_Homo sapiens_hsa052220.42012835
138Peroxisome_Homo sapiens_hsa041460.41788720
139ErbB signaling pathway_Homo sapiens_hsa040120.41171806
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40082676
141Hepatitis B_Homo sapiens_hsa051610.39658289
142Alzheimers disease_Homo sapiens_hsa050100.39496284
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.38987896
144Dorso-ventral axis formation_Homo sapiens_hsa043200.35549138
145AMPK signaling pathway_Homo sapiens_hsa041520.35207370
146Nitrogen metabolism_Homo sapiens_hsa009100.34242686
147Parkinsons disease_Homo sapiens_hsa050120.33321219
148cAMP signaling pathway_Homo sapiens_hsa040240.32272138

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